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Conserved domains on  [gi|1819229363|ref|NP_001365694|]
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traB domain-containing protein isoform c [Homo sapiens]

Protein Classification

TraB domain-containing protein( domain architecture ID 12999407)

TraB domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TraB_PrgY-like cd14726
TraB/PryY confer plasmid-borne pheromone resistance; TraB/PrgY proteins, identified in gut ...
 75-273 1.60e-57

TraB/PryY confer plasmid-borne pheromone resistance; TraB/PrgY proteins, identified in gut bacterium Enterococcus faecalis, are plasmid-borne homologs that are induced by pheromones. Induction rends the host bacterium insensitive to self-induction by its own pheromones, and prevents the transfer of the pheromone-inducible conjugative plasmids to bacteria that already contain it. Based on homology to Tiki activity, it has been proposed that TraB acts as a protease in the inactivation of mating pheromone, cleaving at the amino-terminus. The pheromones are small peptides (7-8 residues) encoded by the bacterial genome, and are specific for particular plasmids, or class of plasmids, which may contain several virulence factors and disseminate rapidly. Plasmid-borne antibiotic resistance and virulence determinants make these elements important contributors to medical problems. Trab/PrygY is a member of a Tiki-like superfamily. Tiki is a membrane-associated metalloprotease (MEROPS family M96) that inhibits Wnt via the cleavage of its amino terminus. Wnt is essential in animal development and homeostasis. In Xenopus, Tiki is critical in head development. In human cells, Tiki inhibits Wnt-signaling. Tiki proteins are also related to erythromycin esterase, gumN plant pathogens, RtxA containing toxins, and Campylobacter Jejuni ChaN heme-binding protein.


:

Pssm-ID: 350608  Cd Length: 177  Bit Score: 185.47  E-value: 1.60e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819229363  75 VYVVGTAHFSDDSKRDVVKTIREVQPDVVVVELCQYRVSMLKMDESTLLREAQELSLEKLqqavrqngLMSGLMQMLLLK 154
Cdd:cd14726     1 VYLVGTAHVSKESAEEVREVIREVKPDVVAVELCESRYEALLDPERWKNTDIKKVIKEKK--------GFLLLANLLLSS 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819229363 155 VSAHITEQLGMAPGGEFREAFKEASKVPfCKFHLGDRPIPVTFKRAiaalsfWqkvrlawglcflsdpiskddverckqk 234
Cdd:cd14726    73 FQKKIGKELGVKPGAEFRAAIEEAEEVG-APVVLGDRDIQITLKRA------W--------------------------- 118

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1819229363 235 DLLEQMMAEMIGEFPDLHRTIVSERDVYLTYMLRQAARR 273
Cdd:cd14726   119 DVLEELLSELAEEFPELKEVLIDERDQYLAHSLRRAAAG 157
 
Name Accession Description Interval E-value
TraB_PrgY-like cd14726
TraB/PryY confer plasmid-borne pheromone resistance; TraB/PrgY proteins, identified in gut ...
 75-273 1.60e-57

TraB/PryY confer plasmid-borne pheromone resistance; TraB/PrgY proteins, identified in gut bacterium Enterococcus faecalis, are plasmid-borne homologs that are induced by pheromones. Induction rends the host bacterium insensitive to self-induction by its own pheromones, and prevents the transfer of the pheromone-inducible conjugative plasmids to bacteria that already contain it. Based on homology to Tiki activity, it has been proposed that TraB acts as a protease in the inactivation of mating pheromone, cleaving at the amino-terminus. The pheromones are small peptides (7-8 residues) encoded by the bacterial genome, and are specific for particular plasmids, or class of plasmids, which may contain several virulence factors and disseminate rapidly. Plasmid-borne antibiotic resistance and virulence determinants make these elements important contributors to medical problems. Trab/PrygY is a member of a Tiki-like superfamily. Tiki is a membrane-associated metalloprotease (MEROPS family M96) that inhibits Wnt via the cleavage of its amino terminus. Wnt is essential in animal development and homeostasis. In Xenopus, Tiki is critical in head development. In human cells, Tiki inhibits Wnt-signaling. Tiki proteins are also related to erythromycin esterase, gumN plant pathogens, RtxA containing toxins, and Campylobacter Jejuni ChaN heme-binding protein.


Pssm-ID: 350608  Cd Length: 177  Bit Score: 185.47  E-value: 1.60e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819229363  75 VYVVGTAHFSDDSKRDVVKTIREVQPDVVVVELCQYRVSMLKMDESTLLREAQELSLEKLqqavrqngLMSGLMQMLLLK 154
Cdd:cd14726     1 VYLVGTAHVSKESAEEVREVIREVKPDVVAVELCESRYEALLDPERWKNTDIKKVIKEKK--------GFLLLANLLLSS 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819229363 155 VSAHITEQLGMAPGGEFREAFKEASKVPfCKFHLGDRPIPVTFKRAiaalsfWqkvrlawglcflsdpiskddverckqk 234
Cdd:cd14726    73 FQKKIGKELGVKPGAEFRAAIEEAEEVG-APVVLGDRDIQITLKRA------W--------------------------- 118

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1819229363 235 DLLEQMMAEMIGEFPDLHRTIVSERDVYLTYMLRQAARR 273
Cdd:cd14726   119 DVLEELLSELAEEFPELKEVLIDERDQYLAHSLRRAAAG 157
COG1916 COG1916
Pheromone shutdown protein TraB, contains GTxH motif (function unknown) [Function unknown];
58-347 6.25e-48

Pheromone shutdown protein TraB, contains GTxH motif (function unknown) [Function unknown];


Pssm-ID: 441520  Cd Length: 392  Bit Score: 166.90  E-value: 6.25e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819229363  58 PNLPRTVTQLvaeDGSRVYVVGTAHFSDDSKRDVVKTIREVQPDVVVVELCQYRVSMLkMDESTLlreaQELSLEKLqqa 137
Cdd:COG1916     2 DESPITRIEL---DGKEIILLGTAHVSQESVEEVREVIEEEKPDAVAVELDESRYQAL-KDPDAW----KDLDIFKV--- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819229363 138 VRQNGLMSGLMQMLLLKVSAHITEQLGMAPGGEFREAFKEASKVPFcKFHLGDRPIPVTFKRAIAALSFWQKVRLAWGLC 217
Cdd:COG1916    71 IKEGKAGLLLANLALSAFQKRLGEQFGIEPGAEMKAAIEAAEERGA-PVALIDRDIQITLKRAWRNMGFWEKLKLLAGLI 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819229363 218 ---FLSDPISKDDVERCKQKDLLEQMMAEMIGEFPDLHRTIVSERDVYLTYMLRQAARRLE----------LPrasdaep 284
Cdd:COG1916   150 aslFSREEISEEEIEKLKEGDVLEALFEEFAEFSPKLKEVLIDERDAYLAHKLREAPARGKkvvavvgaghLP------- 222

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1819229363 285 rkcvpsvvvgvvgmghvpGIEKNWS---TDLNIQEIMTVPPPSVSGRVSRLAVKAAFFGLLGYSLY 347
Cdd:COG1916   223 ------------------GIERYLEepeTLPDLAELEEVPPKSRWPKIIGWLIPALILALFALGFF 270
traB TIGR00261
pheromone shutdown-related protein TraB; traB is a plasmid encoded gene that functions in the ...
 74-273 1.42e-27

pheromone shutdown-related protein TraB; traB is a plasmid encoded gene that functions in the shutdown of the peptide sex pheromone cPD1 which is produced by the plasmid free recipient cell prior to conjugative transfer in Enterococcus faecalis. Once the recipient acquires the plasmid, production of cPD1 is shut down. The gene product may play another role in the other species in the family. [Unknown function, General]


Pssm-ID: 129363  Cd Length: 380  Bit Score: 111.87  E-value: 1.42e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819229363  74 RVYVVGTAHFSDDSKRDVVKTIREVQPDVVVVELCQYRVsmlkmdESTLLREAQELSLEKlqqAVRQNGLMSGLMQMLLL 153
Cdd:TIGR00261   5 TIYILGTAHVSKKSSEEVANLIEILKPDYIAVELDERRY------HSLLNTKWRNLDIDK---VLKQGNAFFLIINLILA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819229363 154 KVSAHITEQLGMAPGGEFREAFKEASK--VPfckFHLGDRPIPVTFKRAIAALSFWQKVRLAWGLCFLSDPISKDDVERC 231
Cdd:TIGR00261  76 NFQKKLGEEQGIKPGSEMKTAIEKAKKhgIP---LILIDRDIETTLKRAWISITFFEKAKIISSLFSSTDAKIEDEIEKL 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1819229363 232 KQKDLLEQMMAEMIGEFPDLHRTIVSERDVYLTYMLRQAARR 273
Cdd:TIGR00261 153 LEQDALSKIMKELSKISPKVKKVLIDERDEFMANKLLEGEGN 194
TraB_PrgY_gumN pfam01963
TraB/PrgY/gumN family; This entry includes Tiki1/2 from humans, TraB/PrgY from the gut flora ...
 68-275 8.25e-17

TraB/PrgY/gumN family; This entry includes Tiki1/2 from humans, TraB/PrgY from the gut flora Enterococcusfaecalis and gumN from the plant pathogen Xanthomonas. Tiki1 is homologous to TraB/PrgY. They have a pair of widely spaced GX2H motifs and a conserved glutamate. From the structural study, this group of proteins have been identified as an ancient metalloprotease clan with a common protein architecture (cobbled from the folds of the EreA/ChaN/PMT group) that mediates proteolytic activities. Tiki1 is a membrane-associated protease that inhibits Wnt via the cleavage of its amino terminus, diminishing Wnt's binding to receptors. TraB/PrgY is an inhibitor peptide that may act as a protease to inactivate the mating pheromone.


Pssm-ID: 426534  Cd Length: 262  Bit Score: 79.32  E-value: 8.25e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819229363  68 VAEDGSRVYVVGTAHFSDDSKRDVVKTIREV--QPDVVVVELCQYR----VSMLKMDESTLLREAQELS-------LEKL 134
Cdd:pfam01963   5 ISKGGTTVYLLGTIHVLPPSVYPLPPAIEEAleAADTVVVELDLSRytdpATQAALPKLGLLPDGKTLSdllspelYARL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819229363 135 QQAVRQNGLMSGLMQMlllkvsahiteqlgMAP--GGEFREAFKEASKVPFCKFHLGDRPIPVTFKRAIAALSFWQKVRL 212
Cdd:pfam01963  85 QKALAKRGLPLAALDR--------------MKPwlAALLLSLAELAKQKAGLDPDLVDRYLAKTAKRAGKPVGGLETVEE 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819229363 213 AWGLCFLSDPISKDDVERC-----KQKDLLEQMMA--------------EMIGEFPDLHRTIVSERDVyltYMLRQAARR 273
Cdd:pfam01963 151 QLALLSLPDEEQLEMLEETldeleKGEDLLETLVEawaegdlealeleaELKEAYPELYEVLLDERNR---YWAEKIEAL 227


                  ..
gi 1819229363 274 LE 275
Cdd:pfam01963 228 LK 229
 
Name Accession Description Interval E-value
TraB_PrgY-like cd14726
TraB/PryY confer plasmid-borne pheromone resistance; TraB/PrgY proteins, identified in gut ...
 75-273 1.60e-57

TraB/PryY confer plasmid-borne pheromone resistance; TraB/PrgY proteins, identified in gut bacterium Enterococcus faecalis, are plasmid-borne homologs that are induced by pheromones. Induction rends the host bacterium insensitive to self-induction by its own pheromones, and prevents the transfer of the pheromone-inducible conjugative plasmids to bacteria that already contain it. Based on homology to Tiki activity, it has been proposed that TraB acts as a protease in the inactivation of mating pheromone, cleaving at the amino-terminus. The pheromones are small peptides (7-8 residues) encoded by the bacterial genome, and are specific for particular plasmids, or class of plasmids, which may contain several virulence factors and disseminate rapidly. Plasmid-borne antibiotic resistance and virulence determinants make these elements important contributors to medical problems. Trab/PrygY is a member of a Tiki-like superfamily. Tiki is a membrane-associated metalloprotease (MEROPS family M96) that inhibits Wnt via the cleavage of its amino terminus. Wnt is essential in animal development and homeostasis. In Xenopus, Tiki is critical in head development. In human cells, Tiki inhibits Wnt-signaling. Tiki proteins are also related to erythromycin esterase, gumN plant pathogens, RtxA containing toxins, and Campylobacter Jejuni ChaN heme-binding protein.


Pssm-ID: 350608  Cd Length: 177  Bit Score: 185.47  E-value: 1.60e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819229363  75 VYVVGTAHFSDDSKRDVVKTIREVQPDVVVVELCQYRVSMLKMDESTLLREAQELSLEKLqqavrqngLMSGLMQMLLLK 154
Cdd:cd14726     1 VYLVGTAHVSKESAEEVREVIREVKPDVVAVELCESRYEALLDPERWKNTDIKKVIKEKK--------GFLLLANLLLSS 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819229363 155 VSAHITEQLGMAPGGEFREAFKEASKVPfCKFHLGDRPIPVTFKRAiaalsfWqkvrlawglcflsdpiskddverckqk 234
Cdd:cd14726    73 FQKKIGKELGVKPGAEFRAAIEEAEEVG-APVVLGDRDIQITLKRA------W--------------------------- 118

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1819229363 235 DLLEQMMAEMIGEFPDLHRTIVSERDVYLTYMLRQAARR 273
Cdd:cd14726   119 DVLEELLSELAEEFPELKEVLIDERDQYLAHSLRRAAAG 157
COG1916 COG1916
Pheromone shutdown protein TraB, contains GTxH motif (function unknown) [Function unknown];
58-347 6.25e-48

Pheromone shutdown protein TraB, contains GTxH motif (function unknown) [Function unknown];


Pssm-ID: 441520  Cd Length: 392  Bit Score: 166.90  E-value: 6.25e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819229363  58 PNLPRTVTQLvaeDGSRVYVVGTAHFSDDSKRDVVKTIREVQPDVVVVELCQYRVSMLkMDESTLlreaQELSLEKLqqa 137
Cdd:COG1916     2 DESPITRIEL---DGKEIILLGTAHVSQESVEEVREVIEEEKPDAVAVELDESRYQAL-KDPDAW----KDLDIFKV--- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819229363 138 VRQNGLMSGLMQMLLLKVSAHITEQLGMAPGGEFREAFKEASKVPFcKFHLGDRPIPVTFKRAIAALSFWQKVRLAWGLC 217
Cdd:COG1916    71 IKEGKAGLLLANLALSAFQKRLGEQFGIEPGAEMKAAIEAAEERGA-PVALIDRDIQITLKRAWRNMGFWEKLKLLAGLI 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819229363 218 ---FLSDPISKDDVERCKQKDLLEQMMAEMIGEFPDLHRTIVSERDVYLTYMLRQAARRLE----------LPrasdaep 284
Cdd:COG1916   150 aslFSREEISEEEIEKLKEGDVLEALFEEFAEFSPKLKEVLIDERDAYLAHKLREAPARGKkvvavvgaghLP------- 222

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1819229363 285 rkcvpsvvvgvvgmghvpGIEKNWS---TDLNIQEIMTVPPPSVSGRVSRLAVKAAFFGLLGYSLY 347
Cdd:COG1916   223 ------------------GIERYLEepeTLPDLAELEEVPPKSRWPKIIGWLIPALILALFALGFF 270
traB TIGR00261
pheromone shutdown-related protein TraB; traB is a plasmid encoded gene that functions in the ...
 74-273 1.42e-27

pheromone shutdown-related protein TraB; traB is a plasmid encoded gene that functions in the shutdown of the peptide sex pheromone cPD1 which is produced by the plasmid free recipient cell prior to conjugative transfer in Enterococcus faecalis. Once the recipient acquires the plasmid, production of cPD1 is shut down. The gene product may play another role in the other species in the family. [Unknown function, General]


Pssm-ID: 129363  Cd Length: 380  Bit Score: 111.87  E-value: 1.42e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819229363  74 RVYVVGTAHFSDDSKRDVVKTIREVQPDVVVVELCQYRVsmlkmdESTLLREAQELSLEKlqqAVRQNGLMSGLMQMLLL 153
Cdd:TIGR00261   5 TIYILGTAHVSKKSSEEVANLIEILKPDYIAVELDERRY------HSLLNTKWRNLDIDK---VLKQGNAFFLIINLILA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819229363 154 KVSAHITEQLGMAPGGEFREAFKEASK--VPfckFHLGDRPIPVTFKRAIAALSFWQKVRLAWGLCFLSDPISKDDVERC 231
Cdd:TIGR00261  76 NFQKKLGEEQGIKPGSEMKTAIEKAKKhgIP---LILIDRDIETTLKRAWISITFFEKAKIISSLFSSTDAKIEDEIEKL 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1819229363 232 KQKDLLEQMMAEMIGEFPDLHRTIVSERDVYLTYMLRQAARR 273
Cdd:TIGR00261 153 LEQDALSKIMKELSKISPKVKKVLIDERDEFMANKLLEGEGN 194
TraB_PrgY_gumN pfam01963
TraB/PrgY/gumN family; This entry includes Tiki1/2 from humans, TraB/PrgY from the gut flora ...
 68-275 8.25e-17

TraB/PrgY/gumN family; This entry includes Tiki1/2 from humans, TraB/PrgY from the gut flora Enterococcusfaecalis and gumN from the plant pathogen Xanthomonas. Tiki1 is homologous to TraB/PrgY. They have a pair of widely spaced GX2H motifs and a conserved glutamate. From the structural study, this group of proteins have been identified as an ancient metalloprotease clan with a common protein architecture (cobbled from the folds of the EreA/ChaN/PMT group) that mediates proteolytic activities. Tiki1 is a membrane-associated protease that inhibits Wnt via the cleavage of its amino terminus, diminishing Wnt's binding to receptors. TraB/PrgY is an inhibitor peptide that may act as a protease to inactivate the mating pheromone.


Pssm-ID: 426534  Cd Length: 262  Bit Score: 79.32  E-value: 8.25e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819229363  68 VAEDGSRVYVVGTAHFSDDSKRDVVKTIREV--QPDVVVVELCQYR----VSMLKMDESTLLREAQELS-------LEKL 134
Cdd:pfam01963   5 ISKGGTTVYLLGTIHVLPPSVYPLPPAIEEAleAADTVVVELDLSRytdpATQAALPKLGLLPDGKTLSdllspelYARL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819229363 135 QQAVRQNGLMSGLMQMlllkvsahiteqlgMAP--GGEFREAFKEASKVPFCKFHLGDRPIPVTFKRAIAALSFWQKVRL 212
Cdd:pfam01963  85 QKALAKRGLPLAALDR--------------MKPwlAALLLSLAELAKQKAGLDPDLVDRYLAKTAKRAGKPVGGLETVEE 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819229363 213 AWGLCFLSDPISKDDVERC-----KQKDLLEQMMA--------------EMIGEFPDLHRTIVSERDVyltYMLRQAARR 273
Cdd:pfam01963 151 QLALLSLPDEEQLEMLEETldeleKGEDLLETLVEawaegdlealeleaELKEAYPELYEVLLDERNR---YWAEKIEAL 227


                  ..
gi 1819229363 274 LE 275
Cdd:pfam01963 228 LK 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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