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Conserved domains on  [gi|1809665862|ref|NP_001365387|]
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dmX-like protein 2 isoform 5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rav1p_C super family cl13644
RAVE protein 1 C terminal; This domain family is found in eukaryotes, and is typically between ...
 1171-1902 1.22e-75

RAVE protein 1 C terminal; This domain family is found in eukaryotes, and is typically between 621 and 644 amino acids in length. This family is the C terminal region of the protein RAVE (regulator of the ATPase of vacuolar and endosomal membranes). Rav1p is involved in regulating the glucose dependent assembly and disassembly of vacuolar ATPase V1 and V0 subunits.


The actual alignment was detected with superfamily member pfam12234:

Pssm-ID: 432413  Cd Length: 637  Bit Score: 266.36  E-value: 1.22e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 1171 LDWVSKEDGSHILTVGVGANIFMYGRLSgivTEQTNSkdgvavitLPlggsikqgvksRWVLLRSIDLVssvDGTPSLPV 1250
Cdd:pfam12234   76 LDWTSTPDSQSILAVGFPHHVLLLTQLR---YDYTNK--------GP-----------SWAPIRKIDIR---DLTPHPIG 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 1251 SLSWVRDGILVVGMDCEMHVYAQWkhavkfgdteadssnAEEAAMQDHSTfksnmlaRKSVVEGTAISDDvfcsptviqd 1330
Cdd:pfam12234  131 DSIWLDDGTLVVAAGNQLFIYDKW---------------LDLRLPDDPFT-------LRSIGSRKILSND---------- 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 1331 ggLFEAAHVLSPTLPQYHPTQLLELMDLGKVRRAKAILSHLVKCIagevaivrdpdagegtkrhlsrtisvsgstaketv 1410
Cdd:pfam12234  179 --LFHLVSVLNGPLPVYHPQFLIQCLLAGKLELVKEILLRLFKEL----------------------------------- 221

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 1411 tvgKDGTRDYTEIDSIPPLPLYALLAaDQDTSYRISEESTkipqsyedqtvSQPEDQYSELFQiqdiptddidlepekre 1490
Cdd:pfam12234  222 ---KFYSEDLEDLDSFLGIDLEKFLK-DDDKAYSKNKAFT-----------SSSDDDDPDPYE----------------- 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 1491 nkskvinlsqygpaYFGQEHARVLSSHLMHSSLPGLTRLEQMFLVALADTVATTSTEldesrdkscsgRDTLDECGLRYL 1570
Cdd:pfam12234  270 --------------TFNEEVASSLNEKLTKISLPQLTRHEQITLINVIEAVGEVEKH-----------RRSLDENGARFL 324

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 1571 LAMRLHTclltslppLYRVQLLHQGVSTCHFAWAFHSEAEEELINMIPAIQRGDPQWSELRAMGIGWWVRNINTLRRCIE 1650
Cdd:pfam12234  325 LGFKLHL--------LHKKRTSQSSLSWRDISWALHSDNQEILLDLVSRHYGNKLLWEAARESGIFMWLKDIEALRAQFE 396

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 1651 KVAKASFQRNN--DALDAALFYLSMKKKAVVWGLFR--SQHDE--KMTTFFSHNFNEDRWRKAALKNAFSLLGKQRFEQS 1724
Cdd:pfam12234  397 VIARNEYTKSDerDPVDCSLFYLALKKKQVLQGLWRmaSWHPEqaKTLKFLSNDFSEPRWRTAALKNAFALLSKHRYEYA 476

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 1725 AAFFLLAGSLKDAIEVCLEKMEDIQLAMVIARLYESefETSSTYISILNQKIL-GCQKDGsgfsckrlhpDPFLRSLAYW 1803
Cdd:pfam12234  477 AAFFLLADSLKDAVNVLLRQLKDLQLAIAVARVYEG--DDGPVLRELLEERVLpLAIKEG----------DRWLASWAFW 544

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 1804 VMK---DYTRAL----DTLLEQTPKEDDEHQVII-KSC---NPVAFSFYNYLRTHPL-LIRRNLASPEgtlatlglKTEK 1871
Cdd:pfam12234  545 MLKrrdLAVRALvtppYDLLENTDLKKSDPASPVsKSFltdDPALVLLYQQLRKKTLqTLKGALKVTP--------KEEY 616

                          730       740       750
                   ....*....|....*....|....*....|.
gi 1809665862 1872 NFVdkinlierklfFTTANAHFKVGCPVLAL 1902
Cdd:pfam12234  617 DFV-----------LRVARIYDRMGCDLLAL 636
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2787-3039 1.02e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 98.18  E-value: 1.02e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 2787 VKRMTSHPVHQYYLTGAQDGSVRMFEWTRPQQLVCFRQAGNArVTRLYFNSQGNKCGVADGEGFLSIWQVNqtasNPKPY 2866
Cdd:cd00200     12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGP-VRDVAASADGTYLASGSSDKTIRLWDLE----TGECV 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 2867 MSWQCHSKATSDFAFITSSSLVATSGhsnDNRNVCLWDTlisPGNSLIHGFTCHDHGATVLQYAPKQQLLISGGRKGHVC 2946
Cdd:cd00200     87 RTLTGHTSYVSSVAFSPDGRILSSSS---RDKTIKVWDV---ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 2947 IFDIRQRQLIHTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVWRLTGHGLIHSFKSeHakqsifrniGAGVMQIDIIQG 3026
Cdd:cd00200    161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG-H---------ENGVNSVAFSPD 230

                          250
                   ....*....|....
gi 1809665862 3027 NRLF-SCGADGTLK 3039
Cdd:cd00200    231 GYLLaSGSEDGTIR 244
WD40 super family cl43672
WD40 repeat [General function prediction only];
45-268 3.59e-03

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 3.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862   45 ECVQIIPGakHGNiQVSCVECSNQQGRIA-ASYGNAVCIFEPLGinshkrncqlkCQWLKTGQFFLSSVtYNLAWDPQDN 123
Cdd:COG2319    195 KLLRTLTG--HTG-AVRSVAFSPDGKLLAsGSADGTVRLWDLAT-----------GKLLRTLTGHSGSV-RSVAFSPDGR 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862  124 RLLTATD--SIQLWAPPGDDILEEEEEIDNTVppvlndwkcvwqckTSVSvhlmeWSPDGEYFATAGkDDCLLKVWYPMT 201
Cdd:COG2319    260 LLASGSAdgTVRLWDLATGELLRTLTGHSGGV--------------NSVA-----FSPDGKLLASGS-DDGTVRLWDLAT 319

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1809665862  202 GWKSSIIPqdhhevkrrqsstqfsfvylAHPRAVTGFSWRktskymPRGsvcNVLLTSCHDGVCRLW 268
Cdd:COG2319    320 GKLLRTLT--------------------GHTGAVRSVAFS------PDG---KTLASGSDDGTVRLW 357
 
Name Accession Description Interval E-value
Rav1p_C pfam12234
RAVE protein 1 C terminal; This domain family is found in eukaryotes, and is typically between ...
 1171-1902 1.22e-75

RAVE protein 1 C terminal; This domain family is found in eukaryotes, and is typically between 621 and 644 amino acids in length. This family is the C terminal region of the protein RAVE (regulator of the ATPase of vacuolar and endosomal membranes). Rav1p is involved in regulating the glucose dependent assembly and disassembly of vacuolar ATPase V1 and V0 subunits.


Pssm-ID: 432413  Cd Length: 637  Bit Score: 266.36  E-value: 1.22e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 1171 LDWVSKEDGSHILTVGVGANIFMYGRLSgivTEQTNSkdgvavitLPlggsikqgvksRWVLLRSIDLVssvDGTPSLPV 1250
Cdd:pfam12234   76 LDWTSTPDSQSILAVGFPHHVLLLTQLR---YDYTNK--------GP-----------SWAPIRKIDIR---DLTPHPIG 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 1251 SLSWVRDGILVVGMDCEMHVYAQWkhavkfgdteadssnAEEAAMQDHSTfksnmlaRKSVVEGTAISDDvfcsptviqd 1330
Cdd:pfam12234  131 DSIWLDDGTLVVAAGNQLFIYDKW---------------LDLRLPDDPFT-------LRSIGSRKILSND---------- 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 1331 ggLFEAAHVLSPTLPQYHPTQLLELMDLGKVRRAKAILSHLVKCIagevaivrdpdagegtkrhlsrtisvsgstaketv 1410
Cdd:pfam12234  179 --LFHLVSVLNGPLPVYHPQFLIQCLLAGKLELVKEILLRLFKEL----------------------------------- 221

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 1411 tvgKDGTRDYTEIDSIPPLPLYALLAaDQDTSYRISEESTkipqsyedqtvSQPEDQYSELFQiqdiptddidlepekre 1490
Cdd:pfam12234  222 ---KFYSEDLEDLDSFLGIDLEKFLK-DDDKAYSKNKAFT-----------SSSDDDDPDPYE----------------- 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 1491 nkskvinlsqygpaYFGQEHARVLSSHLMHSSLPGLTRLEQMFLVALADTVATTSTEldesrdkscsgRDTLDECGLRYL 1570
Cdd:pfam12234  270 --------------TFNEEVASSLNEKLTKISLPQLTRHEQITLINVIEAVGEVEKH-----------RRSLDENGARFL 324

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 1571 LAMRLHTclltslppLYRVQLLHQGVSTCHFAWAFHSEAEEELINMIPAIQRGDPQWSELRAMGIGWWVRNINTLRRCIE 1650
Cdd:pfam12234  325 LGFKLHL--------LHKKRTSQSSLSWRDISWALHSDNQEILLDLVSRHYGNKLLWEAARESGIFMWLKDIEALRAQFE 396

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 1651 KVAKASFQRNN--DALDAALFYLSMKKKAVVWGLFR--SQHDE--KMTTFFSHNFNEDRWRKAALKNAFSLLGKQRFEQS 1724
Cdd:pfam12234  397 VIARNEYTKSDerDPVDCSLFYLALKKKQVLQGLWRmaSWHPEqaKTLKFLSNDFSEPRWRTAALKNAFALLSKHRYEYA 476

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 1725 AAFFLLAGSLKDAIEVCLEKMEDIQLAMVIARLYESefETSSTYISILNQKIL-GCQKDGsgfsckrlhpDPFLRSLAYW 1803
Cdd:pfam12234  477 AAFFLLADSLKDAVNVLLRQLKDLQLAIAVARVYEG--DDGPVLRELLEERVLpLAIKEG----------DRWLASWAFW 544

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 1804 VMK---DYTRAL----DTLLEQTPKEDDEHQVII-KSC---NPVAFSFYNYLRTHPL-LIRRNLASPEgtlatlglKTEK 1871
Cdd:pfam12234  545 MLKrrdLAVRALvtppYDLLENTDLKKSDPASPVsKSFltdDPALVLLYQQLRKKTLqTLKGALKVTP--------KEEY 616

                          730       740       750
                   ....*....|....*....|....*....|.
gi 1809665862 1872 NFVdkinlierklfFTTANAHFKVGCPVLAL 1902
Cdd:pfam12234  617 DFV-----------LRVARIYDRMGCDLLAL 636
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2787-3039 1.02e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.18  E-value: 1.02e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 2787 VKRMTSHPVHQYYLTGAQDGSVRMFEWTRPQQLVCFRQAGNArVTRLYFNSQGNKCGVADGEGFLSIWQVNqtasNPKPY 2866
Cdd:cd00200     12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGP-VRDVAASADGTYLASGSSDKTIRLWDLE----TGECV 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 2867 MSWQCHSKATSDFAFITSSSLVATSGhsnDNRNVCLWDTlisPGNSLIHGFTCHDHGATVLQYAPKQQLLISGGRKGHVC 2946
Cdd:cd00200     87 RTLTGHTSYVSSVAFSPDGRILSSSS---RDKTIKVWDV---ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 2947 IFDIRQRQLIHTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVWRLTGHGLIHSFKSeHakqsifrniGAGVMQIDIIQG 3026
Cdd:cd00200    161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG-H---------ENGVNSVAFSPD 230

                          250
                   ....*....|....
gi 1809665862 3027 NRLF-SCGADGTLK 3039
Cdd:cd00200    231 GYLLaSGSEDGTIR 244
WD40 COG2319
WD40 repeat [General function prediction only];
2787-3039 1.51e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.99  E-value: 1.51e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 2787 VKRMTSHPVHQYYLTGAQDGSVRMFEWTRPQQLVCFrQAGNARVTRLYFNSQGNKCGVADGEGFLSIWQVnqtaSNPKPY 2866
Cdd:COG2319     81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTL-TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL----ATGKLL 155

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 2867 MSWQCHSKATSDFAFITSSSLVATSGhsnDNRNVCLWDTLispGNSLIHGFTCHDHGATVLQYAPKQQLLISGGRKGHVC 2946
Cdd:COG2319    156 RTLTGHSGAVTSVAFSPDGKLLASGS---DDGTVRLWDLA---TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVR 229

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 2947 IFDIRQRQLIHTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVWRLTGHGLIHSFKSEhakqsifrniGAGVMQIDII-Q 3025
Cdd:COG2319    230 LWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH----------SGGVNSVAFSpD 299

                          250
                   ....*....|....
gi 1809665862 3026 GNRLFSCGADGTLK 3039
Cdd:COG2319    300 GKLLASGSDDGTVR 313
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 2952-2990 4.46e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 4.46e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1809665862  2952 QRQLIHTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVW 2990
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
2953-2990 1.20e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 1.20e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1809665862 2953 RQLIHTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVW 2990
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 COG2319
WD40 repeat [General function prediction only];
45-268 3.59e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 3.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862   45 ECVQIIPGakHGNiQVSCVECSNQQGRIA-ASYGNAVCIFEPLGinshkrncqlkCQWLKTGQFFLSSVtYNLAWDPQDN 123
Cdd:COG2319    195 KLLRTLTG--HTG-AVRSVAFSPDGKLLAsGSADGTVRLWDLAT-----------GKLLRTLTGHSGSV-RSVAFSPDGR 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862  124 RLLTATD--SIQLWAPPGDDILEEEEEIDNTVppvlndwkcvwqckTSVSvhlmeWSPDGEYFATAGkDDCLLKVWYPMT 201
Cdd:COG2319    260 LLASGSAdgTVRLWDLATGELLRTLTGHSGGV--------------NSVA-----FSPDGKLLASGS-DDGTVRLWDLAT 319

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1809665862  202 GWKSSIIPqdhhevkrrqsstqfsfvylAHPRAVTGFSWRktskymPRGsvcNVLLTSCHDGVCRLW 268
Cdd:COG2319    320 GKLLRTLT--------------------GHTGAVRSVAFS------PDG---KTLASGSDDGTVRLW 357
 
Name Accession Description Interval E-value
Rav1p_C pfam12234
RAVE protein 1 C terminal; This domain family is found in eukaryotes, and is typically between ...
 1171-1902 1.22e-75

RAVE protein 1 C terminal; This domain family is found in eukaryotes, and is typically between 621 and 644 amino acids in length. This family is the C terminal region of the protein RAVE (regulator of the ATPase of vacuolar and endosomal membranes). Rav1p is involved in regulating the glucose dependent assembly and disassembly of vacuolar ATPase V1 and V0 subunits.


Pssm-ID: 432413  Cd Length: 637  Bit Score: 266.36  E-value: 1.22e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 1171 LDWVSKEDGSHILTVGVGANIFMYGRLSgivTEQTNSkdgvavitLPlggsikqgvksRWVLLRSIDLVssvDGTPSLPV 1250
Cdd:pfam12234   76 LDWTSTPDSQSILAVGFPHHVLLLTQLR---YDYTNK--------GP-----------SWAPIRKIDIR---DLTPHPIG 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 1251 SLSWVRDGILVVGMDCEMHVYAQWkhavkfgdteadssnAEEAAMQDHSTfksnmlaRKSVVEGTAISDDvfcsptviqd 1330
Cdd:pfam12234  131 DSIWLDDGTLVVAAGNQLFIYDKW---------------LDLRLPDDPFT-------LRSIGSRKILSND---------- 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 1331 ggLFEAAHVLSPTLPQYHPTQLLELMDLGKVRRAKAILSHLVKCIagevaivrdpdagegtkrhlsrtisvsgstaketv 1410
Cdd:pfam12234  179 --LFHLVSVLNGPLPVYHPQFLIQCLLAGKLELVKEILLRLFKEL----------------------------------- 221

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 1411 tvgKDGTRDYTEIDSIPPLPLYALLAaDQDTSYRISEESTkipqsyedqtvSQPEDQYSELFQiqdiptddidlepekre 1490
Cdd:pfam12234  222 ---KFYSEDLEDLDSFLGIDLEKFLK-DDDKAYSKNKAFT-----------SSSDDDDPDPYE----------------- 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 1491 nkskvinlsqygpaYFGQEHARVLSSHLMHSSLPGLTRLEQMFLVALADTVATTSTEldesrdkscsgRDTLDECGLRYL 1570
Cdd:pfam12234  270 --------------TFNEEVASSLNEKLTKISLPQLTRHEQITLINVIEAVGEVEKH-----------RRSLDENGARFL 324

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 1571 LAMRLHTclltslppLYRVQLLHQGVSTCHFAWAFHSEAEEELINMIPAIQRGDPQWSELRAMGIGWWVRNINTLRRCIE 1650
Cdd:pfam12234  325 LGFKLHL--------LHKKRTSQSSLSWRDISWALHSDNQEILLDLVSRHYGNKLLWEAARESGIFMWLKDIEALRAQFE 396

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 1651 KVAKASFQRNN--DALDAALFYLSMKKKAVVWGLFR--SQHDE--KMTTFFSHNFNEDRWRKAALKNAFSLLGKQRFEQS 1724
Cdd:pfam12234  397 VIARNEYTKSDerDPVDCSLFYLALKKKQVLQGLWRmaSWHPEqaKTLKFLSNDFSEPRWRTAALKNAFALLSKHRYEYA 476

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 1725 AAFFLLAGSLKDAIEVCLEKMEDIQLAMVIARLYESefETSSTYISILNQKIL-GCQKDGsgfsckrlhpDPFLRSLAYW 1803
Cdd:pfam12234  477 AAFFLLADSLKDAVNVLLRQLKDLQLAIAVARVYEG--DDGPVLRELLEERVLpLAIKEG----------DRWLASWAFW 544

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 1804 VMK---DYTRAL----DTLLEQTPKEDDEHQVII-KSC---NPVAFSFYNYLRTHPL-LIRRNLASPEgtlatlglKTEK 1871
Cdd:pfam12234  545 MLKrrdLAVRALvtppYDLLENTDLKKSDPASPVsKSFltdDPALVLLYQQLRKKTLqTLKGALKVTP--------KEEY 616

                          730       740       750
                   ....*....|....*....|....*....|.
gi 1809665862 1872 NFVdkinlierklfFTTANAHFKVGCPVLAL 1902
Cdd:pfam12234  617 DFV-----------LRVARIYDRMGCDLLAL 636
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2787-3039 1.02e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.18  E-value: 1.02e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 2787 VKRMTSHPVHQYYLTGAQDGSVRMFEWTRPQQLVCFRQAGNArVTRLYFNSQGNKCGVADGEGFLSIWQVNqtasNPKPY 2866
Cdd:cd00200     12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGP-VRDVAASADGTYLASGSSDKTIRLWDLE----TGECV 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 2867 MSWQCHSKATSDFAFITSSSLVATSGhsnDNRNVCLWDTlisPGNSLIHGFTCHDHGATVLQYAPKQQLLISGGRKGHVC 2946
Cdd:cd00200     87 RTLTGHTSYVSSVAFSPDGRILSSSS---RDKTIKVWDV---ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 2947 IFDIRQRQLIHTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVWRLTGHGLIHSFKSeHakqsifrniGAGVMQIDIIQG 3026
Cdd:cd00200    161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG-H---------ENGVNSVAFSPD 230

                          250
                   ....*....|....
gi 1809665862 3027 NRLF-SCGADGTLK 3039
Cdd:cd00200    231 GYLLaSGSEDGTIR 244
WD40 COG2319
WD40 repeat [General function prediction only];
2787-3039 1.51e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.99  E-value: 1.51e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 2787 VKRMTSHPVHQYYLTGAQDGSVRMFEWTRPQQLVCFrQAGNARVTRLYFNSQGNKCGVADGEGFLSIWQVnqtaSNPKPY 2866
Cdd:COG2319     81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTL-TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL----ATGKLL 155

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 2867 MSWQCHSKATSDFAFITSSSLVATSGhsnDNRNVCLWDTLispGNSLIHGFTCHDHGATVLQYAPKQQLLISGGRKGHVC 2946
Cdd:COG2319    156 RTLTGHSGAVTSVAFSPDGKLLASGS---DDGTVRLWDLA---TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVR 229

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 2947 IFDIRQRQLIHTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVWRLTGHGLIHSFKSEhakqsifrniGAGVMQIDII-Q 3025
Cdd:COG2319    230 LWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH----------SGGVNSVAFSpD 299

                          250
                   ....*....|....
gi 1809665862 3026 GNRLFSCGADGTLK 3039
Cdd:COG2319    300 GKLLASGSDDGTVR 313
WD40 COG2319
WD40 repeat [General function prediction only];
2797-3039 4.66e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.44  E-value: 4.66e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 2797 QYYLTGAQDGSVRMFEWTRPQQLVCFRqAGNARVTRLYFNSQGNKCGVADGEGFLSIWQVNqtasNPKPYMSWQCHSKAT 2876
Cdd:COG2319    175 KLLASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA----TGKLLRTLTGHSGSV 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 2877 SDFAFITSSSLVATSGhsnDNRNVCLWDTlisPGNSLIHGFTCHDHGATVLQYAPKQQLLISGGRKGHVCIFDIRQRQLI 2956
Cdd:COG2319    250 RSVAFSPDGRLLASGS---ADGTVRLWDL---ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 2957 HTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVWRLTGHGLIHSFKsEHakqsifrniGAGVMQIDI-IQGNRLFSCGAD 3035
Cdd:COG2319    324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT-GH---------TGAVTSVAFsPDGRTLASGSAD 393


                   ....
gi 1809665862 3036 GTLK 3039
Cdd:COG2319    394 GTVR 397
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2785-3040 5.45e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.09  E-value: 5.45e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 2785 HNVKRMTSHPVHQYYLTGAQDGSVRMFEWTRPQQLVCFRQAgNARVTRLYFNSQGN--KCGVADGEgfLSIWQVNqtasN 2862
Cdd:cd00200     52 GPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGH-TSYVSSVAFSPDGRilSSSSRDKT--IKVWDVE----T 124

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 2863 PKPYMSWQCHSKATSDFAFITSSSLVATSGhsnDNRNVCLWDTlisPGNSLIHGFTCHDHGATVLQYAPKQQLLISGGRK 2942
Cdd:cd00200    125 GKCLTTLRGHTDWVNSVAFSPDGTFVASSS---QDGTIKLWDL---RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSD 198

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 2943 GHVCIFDIRQRQLIHTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVWRLTGHGLIHSFkSEHAKqsifrnigaGVMQID 3022
Cdd:cd00200    199 GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL-SGHTN---------SVTSLA 268

                          250
                   ....*....|....*....
gi 1809665862 3023 IIQ-GNRLFSCGADGTLKT 3040
Cdd:cd00200    269 WSPdGKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2827-3039 1.88e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.55  E-value: 1.88e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 2827 NARVTRLYFNSQGNKCGVADGEGFLSIWQVNqtasNPKPYMSWQCHSKATSDFAFITSSSLVATSGhsnDNRNVCLWDTl 2906
Cdd:cd00200      9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLE----TGELLRTLKGHTGPVRDVAASADGTYLASGS---SDKTIRLWDL- 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 2907 isPGNSLIHGFTCHDHGATVLQYAPKQQLLISGGRKGHVCIFDIRQRQLIHTFQAHDSAIKALALDPYEEYFTTGSAEGN 2986
Cdd:cd00200     81 --ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT 158

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1809665862 2987 IKVWRLTGHGLIHSFKSeHAKQsifrnigagVMQIDII-QGNRLFSCGADGTLK 3039
Cdd:cd00200    159 IKLWDLRTGKCVATLTG-HTGE---------VNSVAFSpDGEKLLSSSSDGTIK 202
WD40 COG2319
WD40 repeat [General function prediction only];
2797-2994 8.44e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.81  E-value: 8.44e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 2797 QYYLTGAQDGSVRMFEWTRPQQLVCFRqAGNARVTRLYFNSQGNKCGVADGEGFLSIWQVNqtasNPKPYMSWQCHSKAT 2876
Cdd:COG2319    217 KLLASGSADGTVRLWDLATGKLLRTLT-GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA----TGELLRTLTGHSGGV 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 2877 SDFAFITSSSLVATSGhsnDNRNVCLWDTlisPGNSLIHGFTCHDHGATVLQYAPKQQLLISGGRKGHVCIFDIRQRQLI 2956
Cdd:COG2319    292 NSVAFSPDGKLLASGS---DDGTVRLWDL---ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL 365

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1809665862 2957 HTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVWRLTG 2994
Cdd:COG2319    366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2793-2991 2.99e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.00  E-value: 2.99e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 2793 HPVHQYYLTGAQDGSVRMFEWTRPQQLVCFRQAgNARVTRLYFNSQGNKCGVADGEGFLSIWQVNqtasNPKPYMSWQCH 2872
Cdd:cd00200    102 SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDGTFVASSSQDGTIKLWDLR----TGKCVATLTGH 176

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 2873 SKATSDFAFITSSSLVATSGhsnDNRNVCLWDTLISpgnSLIHGFTCHDHGATVLQYAPKQQLLISGGRKGHVCIFDIRQ 2952
Cdd:cd00200    177 TGEVNSVAFSPDGEKLLSSS---SDGTIKLWDLSTG---KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRT 250

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1809665862 2953 RQLIHTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVWR 2991
Cdd:cd00200    251 GECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2869-3039 4.80e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 72.37  E-value: 4.80e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 2869 WQCHSKATSDFAFITSSSLVATSGhsnDNRNVCLWDTlisPGNSLIHGFTCHDHGATVLQYAPKQQLLISGGRKGHVCIF 2948
Cdd:cd00200      5 LKGHTGGVTCVAFSPDGKLLATGS---GDGTIKVWDL---ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLW 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 2949 DIRQRQLIHTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVWRLTghglihSFKSEHAkqsiFRNIGAGVMQIDIIQGNR 3028
Cdd:cd00200     79 DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE------TGKCLTT----LRGHTDWVNSVAFSPDGT 148

                          170
                   ....*....|..
gi 1809665862 3029 -LFSCGADGTLK 3039
Cdd:cd00200    149 fVASSSQDGTIK 160
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2913-3039 1.75e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 67.75  E-value: 1.75e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 2913 LIHGFTCHDHGATVLQYAPKQQLLISGGRKGHVCIFDIRQRQLIHTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVWRL 2992
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1809665862 2993 TGHGLIHSFKSeHAKqsifrnigaGVMQIDIIQGNR-LFSCGADGTLK 3039
Cdd:cd00200     81 ETGECVRTLTG-HTS---------YVSSVAFSPDGRiLSSSSRDKTIK 118
WD40 COG2319
WD40 repeat [General function prediction only];
2872-3039 7.37e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.61  E-value: 7.37e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 2872 HSKATSDFAFITSSSLVATSGHSNDNRnvcLWDTLispGNSLIHGFTCHDHGATVLQYAPKQQLLISGGRKGHVCIFDIR 2951
Cdd:COG2319     35 LAAAVASLAASPDGARLAAGAGDLTLL---LLDAA---AGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862 2952 QRQLIHTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVWRLTGHGLIHSFKsEHAkqsifrnigAGVMQIDII-QGNRLF 3030
Cdd:COG2319    109 TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT-GHS---------GAVTSVAFSpDGKLLA 178


                   ....*....
gi 1809665862 3031 SCGADGTLK 3039
Cdd:COG2319    179 SGSDDGTVR 187
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 2952-2990 4.46e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 4.46e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1809665862  2952 QRQLIHTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVW 2990
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
2953-2990 1.20e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 1.20e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1809665862 2953 RQLIHTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVW 2990
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 COG2319
WD40 repeat [General function prediction only];
45-268 3.59e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 3.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862   45 ECVQIIPGakHGNiQVSCVECSNQQGRIA-ASYGNAVCIFEPLGinshkrncqlkCQWLKTGQFFLSSVtYNLAWDPQDN 123
Cdd:COG2319    195 KLLRTLTG--HTG-AVRSVAFSPDGKLLAsGSADGTVRLWDLAT-----------GKLLRTLTGHSGSV-RSVAFSPDGR 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1809665862  124 RLLTATD--SIQLWAPPGDDILEEEEEIDNTVppvlndwkcvwqckTSVSvhlmeWSPDGEYFATAGkDDCLLKVWYPMT 201
Cdd:COG2319    260 LLASGSAdgTVRLWDLATGELLRTLTGHSGGV--------------NSVA-----FSPDGKLLASGS-DDGTVRLWDLAT 319

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1809665862  202 GWKSSIIPqdhhevkrrqsstqfsfvylAHPRAVTGFSWRktskymPRGsvcNVLLTSCHDGVCRLW 268
Cdd:COG2319    320 GKLLRTLT--------------------GHTGAVRSVAFS------PDG---KTLASGSDDGTVRLW 357
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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