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Conserved domains on  [gi|1804891951|ref|NP_001365157|]
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tryptophan--tRNA ligase, mitochondrial isoform 4 [Homo sapiens]

Protein Classification

tryptophan--tRNA ligase( domain architecture ID 1000926)

tryptophan--tRNA ligase is a class I tRNA synthetase and aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA

EC:  6.1.1.2
Gene Ontology:  GO:0006436|GO:0004830|GO:0005524

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK00927 super family cl35130
tryptophanyl-tRNA synthetase; Reviewed
 34-303 1.11e-116

tryptophanyl-tRNA synthetase; Reviewed


The actual alignment was detected with superfamily member PRK00927:

Pssm-ID: 234866 [Multi-domain]  Cd Length: 333  Bit Score: 338.99  E-value: 1.11e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  34 KKRVFSGIQPTGILHLGNYLGAIESW------------------------------------------------------ 59
Cdd:PRK00927    1 KKRVLSGIQPTGKLHLGNYLGAIKNWvelqdeyecffciadlhaltvpqdpeelrentrelaadylacgidpekstifvq 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  60 --VSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQ 137
Cdd:PRK00927   81 shVPEHAELAWILNCITPLGELERMTQFKDKSAKQKENVSAGLFTYPVLMAADILLYKADLVPVGEDQKQHLELTRDIAR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 138 GFNKKYGEFFPVPESILTSMK-KVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFT--SEVTYDPAGRAG 214
Cdd:PRK00927  161 RFNNLYGEVFPVPEPLIPKVGaRVMGLDGPTKKMSKSDPNDNNTINLLDDPKTIAKKIKKAVTDSErlREIRYDLPNKPE 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 215 VSNIVAVHAAVTGLSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKVLQIGSAKAKELAYTV 292
Cdd:PRK00927  241 VSNLLTIYSALSGESIEELEAeyEAGGKGYGDFKKDLAEAVVEFLAPIRERYEELLADPAYLDEILAEGAEKARAVASKT 320

                         330
                  ....*....|.
gi 1804891951 293 CQEVKKLVGFL 303
Cdd:PRK00927  321 LKEVREAMGLL 331
 
Name Accession Description Interval E-value
PRK00927 PRK00927
tryptophanyl-tRNA synthetase; Reviewed
 34-303 1.11e-116

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 234866 [Multi-domain]  Cd Length: 333  Bit Score: 338.99  E-value: 1.11e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  34 KKRVFSGIQPTGILHLGNYLGAIESW------------------------------------------------------ 59
Cdd:PRK00927    1 KKRVLSGIQPTGKLHLGNYLGAIKNWvelqdeyecffciadlhaltvpqdpeelrentrelaadylacgidpekstifvq 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  60 --VSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQ 137
Cdd:PRK00927   81 shVPEHAELAWILNCITPLGELERMTQFKDKSAKQKENVSAGLFTYPVLMAADILLYKADLVPVGEDQKQHLELTRDIAR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 138 GFNKKYGEFFPVPESILTSMK-KVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFT--SEVTYDPAGRAG 214
Cdd:PRK00927  161 RFNNLYGEVFPVPEPLIPKVGaRVMGLDGPTKKMSKSDPNDNNTINLLDDPKTIAKKIKKAVTDSErlREIRYDLPNKPE 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 215 VSNIVAVHAAVTGLSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKVLQIGSAKAKELAYTV 292
Cdd:PRK00927  241 VSNLLTIYSALSGESIEELEAeyEAGGKGYGDFKKDLAEAVVEFLAPIRERYEELLADPAYLDEILAEGAEKARAVASKT 320

                         330
                  ....*....|.
gi 1804891951 293 CQEVKKLVGFL 303
Cdd:PRK00927  321 LKEVREAMGLL 331
TrpS COG0180
Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; ...
 33-303 2.12e-110

Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tryptophanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439950 [Multi-domain]  Cd Length: 330  Bit Score: 323.15  E-value: 2.12e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  33 SKKRVFSGIQPTGILHLGNYLGAIESW----------------------------------------------------- 59
Cdd:COG0180     2 SKKRVLSGIQPTGRLHLGNYLGALKNWvelqdeyecfffiadlhalttpqdpeelrentrevaadylaagldpekstifv 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  60 ---VSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDG-TVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDL 135
Cdd:COG0180    82 qsdVPEHAELAWLLSCLTPLGELERMPQFKDKSAKNGKENvNAGLLTYPVLMAADILLYKADLVPVGEDQKQHLELTRDI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 136 AQGFNKKYGEFFPVPESILT-SMKKVKSLrDPSAKMSKSDpdkLATVRITDSPEEIVQKFRKAVTDfTSEVTYDPAGRAG 214
Cdd:COG0180   162 ARRFNHRYGEVFPEPEALIPeEGARIPGL-DGRKKMSKSY---GNTINLLDDPKEIRKKIKSAVTD-SERLRYDDPGKPE 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 215 VSNIVAVHAAVTG-LSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKVLQIGSAKAKELAYT 291
Cdd:COG0180   237 VCNLFTIYSAFSGkEEVEELEAeyRAGGIGYGDLKKALAEAVVEFLAPIRERRAELLADPAELDEILAEGAEKARAIAAK 316

                         330
                  ....*....|..
gi 1804891951 292 VCQEVKKLVGFL 303
Cdd:COG0180   317 TLAEVREAMGLL 328
TrpRS_core cd00806
catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) ...
 36-255 3.20e-93

catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. TrpRS is a homodimer which attaches Tyr to the appropriate tRNA. TrpRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding


Pssm-ID: 173903 [Multi-domain]  Cd Length: 280  Bit Score: 277.54  E-value: 3.20e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  36 RVFSGIQPTGILHLGNYLGAIESW-------------------------------------------------------- 59
Cdd:cd00806     1 RVLSGIQPSGSLHLGHYLGAFRFWvwlqeagyelfffiadlhaltvkqldpeelrqntrenakdylacgldpekstiffq 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  60 --VSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDgTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQ 137
Cdd:cd00806    81 sdVPEHYELAWLLSCVVTFGELERMTGFKDKSAQGESV-NIGLLTYPVLQAADILLYKACLVPVGIDQDPHLELTRDIAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 138 GFNKKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDklATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGVSN 217
Cdd:cd00806   160 RFNKLYGEIFPKPAALLSKGAFLPGLQGPSKKMSKSDPN--NAIFLTDSPKEIKKKIMKAATDGGRTEHRRDGGGPGVSN 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1804891951 218 IVAVHAAVTGLSVEEVVR----RSAGMNTARYKLAVADAVIE 255
Cdd:cd00806   238 LVEIYSAFFNDDDEELEEideyRSGGLGYGECKKLLAEAIQE 279
trpS TIGR00233
tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members ...
 33-302 6.36e-67

tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members of the family have a pfam00458 domain amino-terminal to the region described by this model. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272975 [Multi-domain]  Cd Length: 327  Bit Score: 212.19  E-value: 6.36e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  33 SKKRVFSGIQPTGILHLGNYLGAIESW----------------------------------------------------- 59
Cdd:TIGR00233   1 KKFRVLTGIQPSGKMHLGHYLGAIQTKwlqqfgvelficiadlhaitvkqtdpdalrkareelaadylavgldpektfif 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  60 ----VSEHTQLSWILSCMVRLPRLQHLHQWKAKTtkQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDL 135
Cdd:TIGR00233  81 lqsdYPEHYELAWLLSCQVTFGELKRMTQFKDKS--QAENVPIGLLSYPVLQAADILLYQADLVPVGIDQDQHLELTRDL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 136 AQGFNKKYGEFFPVPESILT-SMKKVKSLRDpsAKMSKSDPDklATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAGRAG 214
Cdd:TIGR00233 159 AERFNKKFKNFFPKPESLISkFFPRLMGLSG--KKMSKSDPN--SAIFLTDTPKQIKKKIRKAATDGGRVTLFEHREKPG 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 215 VSNIVAVHAAVT-----GLSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKREIEklKLDKDHLEKVLQIGSAKAKE 287
Cdd:TIGR00233 235 VPNLLVIYQYLSfflidDDKLKEIYEayKSGKLGYGECKKALIEVLQEFLKEIQERRA--EIAEEILDKILEPGAKKARE 312

                         330
                  ....*....|....*
gi 1804891951 288 LAYTVCQEVKKLVGF 302
Cdd:TIGR00233 313 TANKTLADVYKAMGL 327
tRNA-synt_1b pfam00579
tRNA synthetases class I (W and Y);
30-258 8.38e-41

tRNA synthetases class I (W and Y);


Pssm-ID: 395461 [Multi-domain]  Cd Length: 292  Bit Score: 143.19  E-value: 8.38e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  30 QKDSKKRVFSGIQPTGILHLGnYLGAIESWVS------------------------------------------------ 61
Cdd:pfam00579   1 KKNRPLRVYSGIDPTGPLHLG-YLVPLMKLRQfqqaghevffligdlhaiigdpsksperkllsretvlenaikaqlacg 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  62 ---------------EHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDG--TVGLLTYPVLQAADILLYKSTHVPVGED 124
Cdd:pfam00579  80 ldpekaeivnnsdwlEHLELAWLLRDLGKHFSLNRMLQFKDVKKRLEQGPgiSLGEFTYPLLQAYDILLLKADLQPGGSD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 125 QVQHMELVQDLAQGFNKKygeFFPVPESILTsmkKVKSLRDPSAKMSKSDPdkLATVRITDSPEEIVQKFRKAVTDFTSE 204
Cdd:pfam00579 160 QWGNIELGRDLARRFNKK---IFKKPVGLTN---PLLTGLDGGKKMSKSAG--NSAIFLDDDPESVYKKIQKAYTDPDRE 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1804891951 205 VTYDPAGRAGVSN-IVAVHAAVTGLSV---------EEVVRRSAGMNtarYKLAVADAVIEKFA 258
Cdd:pfam00579 232 VRKDLKLFTFLSNeEIEILEAELGKSPyreaeellaREVTGLVHGGD---LKKAAAEAVNKLLQ 292
 
Name Accession Description Interval E-value
PRK00927 PRK00927
tryptophanyl-tRNA synthetase; Reviewed
 34-303 1.11e-116

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 234866 [Multi-domain]  Cd Length: 333  Bit Score: 338.99  E-value: 1.11e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  34 KKRVFSGIQPTGILHLGNYLGAIESW------------------------------------------------------ 59
Cdd:PRK00927    1 KKRVLSGIQPTGKLHLGNYLGAIKNWvelqdeyecffciadlhaltvpqdpeelrentrelaadylacgidpekstifvq 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  60 --VSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQ 137
Cdd:PRK00927   81 shVPEHAELAWILNCITPLGELERMTQFKDKSAKQKENVSAGLFTYPVLMAADILLYKADLVPVGEDQKQHLELTRDIAR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 138 GFNKKYGEFFPVPESILTSMK-KVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFT--SEVTYDPAGRAG 214
Cdd:PRK00927  161 RFNNLYGEVFPVPEPLIPKVGaRVMGLDGPTKKMSKSDPNDNNTINLLDDPKTIAKKIKKAVTDSErlREIRYDLPNKPE 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 215 VSNIVAVHAAVTGLSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKVLQIGSAKAKELAYTV 292
Cdd:PRK00927  241 VSNLLTIYSALSGESIEELEAeyEAGGKGYGDFKKDLAEAVVEFLAPIRERYEELLADPAYLDEILAEGAEKARAVASKT 320

                         330
                  ....*....|.
gi 1804891951 293 CQEVKKLVGFL 303
Cdd:PRK00927  321 LKEVREAMGLL 331
TrpS COG0180
Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; ...
 33-303 2.12e-110

Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tryptophanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439950 [Multi-domain]  Cd Length: 330  Bit Score: 323.15  E-value: 2.12e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  33 SKKRVFSGIQPTGILHLGNYLGAIESW----------------------------------------------------- 59
Cdd:COG0180     2 SKKRVLSGIQPTGRLHLGNYLGALKNWvelqdeyecfffiadlhalttpqdpeelrentrevaadylaagldpekstifv 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  60 ---VSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDG-TVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDL 135
Cdd:COG0180    82 qsdVPEHAELAWLLSCLTPLGELERMPQFKDKSAKNGKENvNAGLLTYPVLMAADILLYKADLVPVGEDQKQHLELTRDI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 136 AQGFNKKYGEFFPVPESILT-SMKKVKSLrDPSAKMSKSDpdkLATVRITDSPEEIVQKFRKAVTDfTSEVTYDPAGRAG 214
Cdd:COG0180   162 ARRFNHRYGEVFPEPEALIPeEGARIPGL-DGRKKMSKSY---GNTINLLDDPKEIRKKIKSAVTD-SERLRYDDPGKPE 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 215 VSNIVAVHAAVTG-LSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKVLQIGSAKAKELAYT 291
Cdd:COG0180   237 VCNLFTIYSAFSGkEEVEELEAeyRAGGIGYGDLKKALAEAVVEFLAPIRERRAELLADPAELDEILAEGAEKARAIAAK 316

                         330
                  ....*....|..
gi 1804891951 292 VCQEVKKLVGFL 303
Cdd:COG0180   317 TLAEVREAMGLL 328
TrpRS_core cd00806
catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) ...
 36-255 3.20e-93

catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. TrpRS is a homodimer which attaches Tyr to the appropriate tRNA. TrpRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding


Pssm-ID: 173903 [Multi-domain]  Cd Length: 280  Bit Score: 277.54  E-value: 3.20e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  36 RVFSGIQPTGILHLGNYLGAIESW-------------------------------------------------------- 59
Cdd:cd00806     1 RVLSGIQPSGSLHLGHYLGAFRFWvwlqeagyelfffiadlhaltvkqldpeelrqntrenakdylacgldpekstiffq 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  60 --VSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDgTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQ 137
Cdd:cd00806    81 sdVPEHYELAWLLSCVVTFGELERMTGFKDKSAQGESV-NIGLLTYPVLQAADILLYKACLVPVGIDQDPHLELTRDIAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 138 GFNKKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDklATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGVSN 217
Cdd:cd00806   160 RFNKLYGEIFPKPAALLSKGAFLPGLQGPSKKMSKSDPN--NAIFLTDSPKEIKKKIMKAATDGGRTEHRRDGGGPGVSN 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1804891951 218 IVAVHAAVTGLSVEEVVR----RSAGMNTARYKLAVADAVIE 255
Cdd:cd00806   238 LVEIYSAFFNDDDEELEEideyRSGGLGYGECKKLLAEAIQE 279
PLN02886 PLN02886
aminoacyl-tRNA ligase
 23-303 1.30e-74

aminoacyl-tRNA ligase


Pssm-ID: 215478 [Multi-domain]  Cd Length: 389  Bit Score: 233.94  E-value: 1.30e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  23 SAAAPALQKDS------KKRVFSGIQPTGILHLGNYLGAIESW------------------------------------- 59
Cdd:PLN02886   29 ATAATAPEKEAppkvarKKRVVSGVQPTGSIHLGNYLGAIKNWvalqetydtffcvvdlhaitlphdprelgkatrstaa 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  60 -------------------VSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQ-KHDGTVGLLTYPVLQAADILLYKSTHV 119
Cdd:PLN02886  109 iylacgidpskasvfvqshVPAHAELMWLLSCSTPIGWLNKMIQFKEKSRKAgDENVGVGLLTYPVLMASDILLYQADLV 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 120 PVGEDQVQHMELVQDLAQGFNKKYG------------EFFPVPES-ILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDS 186
Cdd:PLN02886  189 PVGEDQKQHLELTRDIAERVNNLYGgrkwkklggrggSVFKVPEAlIPPAGARVMSLTDGTSKMSKSAPSDQSRINLLDP 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 187 PEEIVQKFRKAVTDFTSEVTYDPAGRAGVSNIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVIEKFAPIKREIEK 266
Cdd:PLN02886  269 PDVIANKIKRCKTDSFPGLEFDNPERPECNNLLSIYQLVTGKTKEEVLAECGDMRWGDFKPLLTDALIEHLSPIQVRYEE 348

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1804891951 267 LKLDKDHLEKVLQIGSAKAKELAYTVCQEVKKLVGFL 303
Cdd:PLN02886  349 IMSDPSYLDSVLKEGADAAAEIADRTLANVYQAMGFV 385
trpS TIGR00233
tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members ...
 33-302 6.36e-67

tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members of the family have a pfam00458 domain amino-terminal to the region described by this model. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272975 [Multi-domain]  Cd Length: 327  Bit Score: 212.19  E-value: 6.36e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  33 SKKRVFSGIQPTGILHLGNYLGAIESW----------------------------------------------------- 59
Cdd:TIGR00233   1 KKFRVLTGIQPSGKMHLGHYLGAIQTKwlqqfgvelficiadlhaitvkqtdpdalrkareelaadylavgldpektfif 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  60 ----VSEHTQLSWILSCMVRLPRLQHLHQWKAKTtkQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDL 135
Cdd:TIGR00233  81 lqsdYPEHYELAWLLSCQVTFGELKRMTQFKDKS--QAENVPIGLLSYPVLQAADILLYQADLVPVGIDQDQHLELTRDL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 136 AQGFNKKYGEFFPVPESILT-SMKKVKSLRDpsAKMSKSDPDklATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAGRAG 214
Cdd:TIGR00233 159 AERFNKKFKNFFPKPESLISkFFPRLMGLSG--KKMSKSDPN--SAIFLTDTPKQIKKKIRKAATDGGRVTLFEHREKPG 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 215 VSNIVAVHAAVT-----GLSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKREIEklKLDKDHLEKVLQIGSAKAKE 287
Cdd:TIGR00233 235 VPNLLVIYQYLSfflidDDKLKEIYEayKSGKLGYGECKKALIEVLQEFLKEIQERRA--EIAEEILDKILEPGAKKARE 312

                         330
                  ....*....|....*
gi 1804891951 288 LAYTVCQEVKKLVGF 302
Cdd:TIGR00233 313 TANKTLADVYKAMGL 327
PRK12282 PRK12282
tryptophanyl-tRNA synthetase II; Reviewed
 33-301 1.69e-45

tryptophanyl-tRNA synthetase II; Reviewed


Pssm-ID: 183400 [Multi-domain]  Cd Length: 333  Bit Score: 156.55  E-value: 1.69e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  33 SKKRVFSGIQPTGILHLGNYLGA--------------------------------------------------------- 55
Cdd:PRK12282    1 TKPIILTGDRPTGKLHLGHYVGSlknrvalqneheqfvliadqqaltdnaknpekirrnilevaldylavgidpakstif 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  56 IESWVSEHTQLSWILSCMVRLPRLQHLHQWKAKTtKQKHDG---TVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELV 132
Cdd:PRK12282   81 IQSQIPELAELTMYYMNLVTVARLERNPTVKTEI-AQKGFGrsiPAGFLTYPVSQAADITAFKATLVPVGDDQLPMIEQT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 133 QDLAQGFNKKYG-EFFPVPESILTSMKKVKSLrDPSAKMSKSDPDKLAtvrITDSPEEIVQKFRKAVTDfTSEVTYDPAG 211
Cdd:PRK12282  160 REIVRRFNSLYGtDVLVEPEALLPEAGRLPGL-DGKAKMSKSLGNAIY---LSDDADTIKKKVMSMYTD-PNHIRVEDPG 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 212 RAGVSNIVAVHAAV--TGLSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKVLQIGSAKAKE 287
Cdd:PRK12282  235 KVEGNVVFTYLDAFdpDKAEVAELKAhyQRGGLGDVKCKRYLEEVLQELLAPIRERRAEFAKDPGYVLEILKAGSEKARE 314

                         330
                  ....*....|....
gi 1804891951 288 LAYTVCQEVKKLVG 301
Cdd:PRK12282  315 VAAQTLSEVKDAMG 328
PRK12556 PRK12556
tryptophanyl-tRNA synthetase; Provisional
 32-302 3.87e-41

tryptophanyl-tRNA synthetase; Provisional


Pssm-ID: 183592 [Multi-domain]  Cd Length: 332  Bit Score: 145.25  E-value: 3.87e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  32 DSKKRVFSGIQPTGILHLGNYLGAIE-----------------------------------------SW----------- 59
Cdd:PRK12556    1 MSEKIMLTGIKPTGYPHLGNYIGAIKpalqmaknyegkalyfiadyhalnavhdpeqfrsytrevaaTWlslgldpedvi 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  60 ------VSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDG-------TVGLLTYPVLQAADILLYKSTHVPVGEDQV 126
Cdd:PRK12556   81 fyrqsdVPEIFELAWILSCLTPKGLMNRAHAYKAKVDQNKEAGldldagvNMGLYTYPILMAADILLFQATHVPVGKDQI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 127 QHMELVQDLAQGFNKKYGEFFPVPESILTSMKKVKSLRDpSAKMSKSDPDklaTVRITDSPEEIVQKFRKAVTDFT-SEV 205
Cdd:PRK12556  161 QHIEIARDIATYFNHTFGDTFTLPEYVIQEEGAILPGLD-GRKMSKSYGN---VIPLFAEQEKLRKLIFKIKTDSSlPNE 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 206 TYDPAGragvSNIVAVHAA-VTGLSVEEV-VRRSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKVLQIGSA 283
Cdd:PRK12556  237 PKDPET----SALFTIYKEfATEEEVQSMrEKYETGIGWGDVKKELFRVVDRELAGPREKYAMYMNEPSLLDEALEKGAE 312

                         330
                  ....*....|....*....
gi 1804891951 284 KAKELAYTVCQEVKKLVGF 302
Cdd:PRK12556  313 RAREIAKPNLAEIKKAIGF 331
tRNA-synt_1b pfam00579
tRNA synthetases class I (W and Y);
30-258 8.38e-41

tRNA synthetases class I (W and Y);


Pssm-ID: 395461 [Multi-domain]  Cd Length: 292  Bit Score: 143.19  E-value: 8.38e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  30 QKDSKKRVFSGIQPTGILHLGnYLGAIESWVS------------------------------------------------ 61
Cdd:pfam00579   1 KKNRPLRVYSGIDPTGPLHLG-YLVPLMKLRQfqqaghevffligdlhaiigdpsksperkllsretvlenaikaqlacg 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  62 ---------------EHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDG--TVGLLTYPVLQAADILLYKSTHVPVGED 124
Cdd:pfam00579  80 ldpekaeivnnsdwlEHLELAWLLRDLGKHFSLNRMLQFKDVKKRLEQGPgiSLGEFTYPLLQAYDILLLKADLQPGGSD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 125 QVQHMELVQDLAQGFNKKygeFFPVPESILTsmkKVKSLRDPSAKMSKSDPdkLATVRITDSPEEIVQKFRKAVTDFTSE 204
Cdd:pfam00579 160 QWGNIELGRDLARRFNKK---IFKKPVGLTN---PLLTGLDGGKKMSKSAG--NSAIFLDDDPESVYKKIQKAYTDPDRE 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1804891951 205 VTYDPAGRAGVSN-IVAVHAAVTGLSV---------EEVVRRSAGMNtarYKLAVADAVIEKFA 258
Cdd:pfam00579 232 VRKDLKLFTFLSNeEIEILEAELGKSPyreaeellaREVTGLVHGGD---LKKAAAEAVNKLLQ 292
PRK12284 PRK12284
tryptophanyl-tRNA synthetase; Reviewed
 36-301 6.69e-30

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 237036 [Multi-domain]  Cd Length: 431  Bit Score: 117.41  E-value: 6.69e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  36 RVFSGIQPTGILHLGNYLGAIE-----------------------------------------SW--------------- 59
Cdd:PRK12284    4 RVLTGITTTGTPHLGNYAGAIRpaiaasrqpgvesfyfladyhalikcddpariqrstleiaaTWlaagldpervtfyrq 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  60 --VSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDG-------TVGLLTYPVLQAADILLYKSTHVPVGEDQVQHME 130
Cdd:PRK12284   84 sdIPEIPELTWLLTCVAGKGLLNRAHAYKAAVDKNVAAGedpdagvTAGLFMYPVLMAADILMFNAHKVPVGRDQIQHIE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 131 LVQDLAQGFNKKYG-EFFPVPESILTsmKKVKSL-----RdpsaKMSKSDPDklaTVRITDSPEEIVQKFRKAVTDftSE 204
Cdd:PRK12284  164 MARDIAQRFNHLYGgEFFVLPEAVIE--ESVATLpgldgR----KMSKSYDN---TIPLFAPREELKKAIFSIVTD--SR 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 205 VTYDPAGRAGvSNIVAVHAAVTGLSVEEVVRRS--AGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKVLQIGS 282
Cdd:PRK12284  233 APGEPKDTEG-SALFQLYQAFATPEETAAFRQAlaDGIGWGDAKQRLFERIDRELAPMRERYEALIARPADIEDILLAGA 311

                         330
                  ....*....|....*....
gi 1804891951 283 AKAKELAYTVCQEVKKLVG 301
Cdd:PRK12284  312 AKARRIATPFLAELREAVG 330
PRK12283 PRK12283
tryptophanyl-tRNA synthetase; Reviewed
 33-301 5.67e-28

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 183401 [Multi-domain]  Cd Length: 398  Bit Score: 111.58  E-value: 5.67e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  33 SKKRVFSGIQPTGILHLGNYLGA--------------------------------------------------------- 55
Cdd:PRK12283    1 FPDRVLSGMRPTGRLHLGHYHGVlknwvklqheyecfffvadwhaltthyetpevieknvwdmvidwlaagvdpaqatlf 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  56 IESWVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHD--GTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQ 133
Cdd:PRK12283   81 IQSKVPEHAELHLLLSMITPLGWLERVPTYKDQQEKLKEKdlSTYGFLGYPLLQSADILIYRAGLVPVGEDQVPHVEMTR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 134 DLAQGFNKKYG--------------------------------------------------------------------- 144
Cdd:PRK12283  161 EIARRFNHLYGrepgfeekaeaaikklgkkraklyhelrnayqeegddealeqarallqeqqnlsmgdrerlfgylegag 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 145 -EFFPVPESILTSMKKVKSLrdPSAKMSKSDPDklaTVRITDSPEEIVQKFRKAVTDFTSEVTYDPaGRAGVSNIVAVHA 223
Cdd:PRK12283  241 kIILPEPQALLTEASKMPGL--DGQKMSKSYGN---TIGLREDPESVTKKIRTMPTDPARVRRTDP-GDPEKCPVWQLHQ 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 224 AVTGLSVEEVVR---RSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKVLQIGSAKAKELAYTVCQEVKKLV 300
Cdd:PRK12283  315 VYSDEETKEWVQkgcRSAGIGCLECKQPVIDAILREQQPMRERAQKYEDDPSLVRAIVADGCEKARKVARETMRDVREAM 394


                  .
gi 1804891951 301 G 301
Cdd:PRK12283  395 G 395
Tyr_Trp_RS_core cd00395
catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Tyrosinyl-tRNA ...
 63-255 7.08e-20

catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS)/Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. These enzymes attach Tyr or Trp, respectively, to the appropriate tRNA. These class I enzymes are homodimers, which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173893 [Multi-domain]  Cd Length: 273  Bit Score: 86.97  E-value: 7.08e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  63 HTQLSWILSCMVRLPRLQHLHQWKAKTtkqKHDGTVGLLTYPVLQAADILLYKSTH----VPVGEDQVQHMELVQDLAQG 138
Cdd:cd00395   100 HIQFLRDLGKHVYVNYMERKTSFQSRS---EEGISATEFTYPPLQAADFLLLNTTEgcdiQPGGSDQWGNITLGRELARR 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 139 FNkkygeFFPVPESILTSMkkVKSLRDPsaKMSKSDPDKLATVRITDSPEEIVQKFRKAVtdftsevtydpagragVSNI 218
Cdd:cd00395   177 FN-----GFTIAEGLTIPL--VTKLDGP--KFGKSESGPKWLDTEKTSPYEFYQFWINAV----------------DSDV 231

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1804891951 219 VAVHAAVTGLSVEEVVRRSAGMNTAR----YKLAVADAVIE 255
Cdd:cd00395   232 INILKYFTFLSKEEIERLEQEQYEAPgyrvAQKTLAEEVTK 272
PRK12285 PRK12285
tryptophanyl-tRNA synthetase; Reviewed
 97-199 6.43e-16

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 237037 [Multi-domain]  Cd Length: 368  Bit Score: 77.21  E-value: 6.43e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  97 TVGLLTYPVLQAADILL------YKSTHVPVGEDQVQHMELVQDLAQGFNKKYGefFPVPESILtsMKKVKSLRdpSAKM 170
Cdd:PRK12285  179 NIGHIFYPATQAADILHpqleegPKPTLVPVGIDQDPHIRLTRDIAERLHGGYG--FIKPSSTY--HKFMPGLT--GGKM 252

                          90       100
                  ....*....|....*....|....*....
gi 1804891951 171 SKSDPDklATVRITDSPEEIVQKFRKAVT 199
Cdd:PRK12285  253 SSSKPE--SAIYLTDDPETVKKKIMKALT 279
PRK08560 PRK08560
tyrosyl-tRNA synthetase; Validated
 95-197 7.96e-09

tyrosyl-tRNA synthetase; Validated


Pssm-ID: 236286 [Multi-domain]  Cd Length: 329  Bit Score: 55.64  E-value: 7.96e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  95 DGTVGLLTYPVLQAADILlYKSTHVPV-GEDQVQ-HMeLVQDLAQGFNkkygefFPVPESILTSMkkVKSLRDPSAKMSK 172
Cdd:PRK08560  148 EPDVSKLVYPLMQVADIF-YLDVDIAVgGMDQRKiHM-LAREVLPKLG------YKKPVCIHTPL--LTGLDGGGIKMSK 217

                          90       100
                  ....*....|....*....|....*
gi 1804891951 173 SDPDklATVRITDSPEEIVQKFRKA 197
Cdd:PRK08560  218 SKPG--SAIFVHDSPEEIRRKIKKA 240
class_I_aaRS_core cd00802
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ...
 37-174 2.91e-07

catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173901 [Multi-domain]  Cd Length: 143  Bit Score: 49.02  E-value: 2.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  37 VFSGIQPTGILHLGNYLGAIESWV--SEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTV--------GLLTYPVL 106
Cdd:cd00802     2 TFSGITPNGYLHIGHLRTIVTFDFlaQAYRKLGYKVRCIALIDDAGGLIGDPANKKGENAKAFVerwierikEDVEYMFL 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1804891951 107 QAADILL---YKSTHVPVGEDQVQHMELVQDLAQGFNKKYgeffpVPESILTSMKKVKSLRdpsaKMSKSD 174
Cdd:cd00802    82 QAADFLLlyeTECDIHLGGSDQLGHIELGLELLKKAGGPA-----RPFGLTFGRVMGADGT----KMSKSK 143
PTZ00126 PTZ00126
tyrosyl-tRNA synthetase; Provisional
 101-197 6.66e-06

tyrosyl-tRNA synthetase; Provisional


Pssm-ID: 240282 [Multi-domain]  Cd Length: 383  Bit Score: 46.99  E-value: 6.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 101 LTYPVLQAADILLYKSTHVPVGEDQVQhmelVQDLAqgfnKKYGEFFPVPES-ILTSMKKVKSLRDPSAKMSKSDPDklA 179
Cdd:PTZ00126  196 ILYPCMQCADIFYLKADICQLGMDQRK----VNMLA----REYCDKKKIKKKpIILSHHMLPGLLEGQEKMSKSDPN--S 265

                          90
                  ....*....|....*...
gi 1804891951 180 TVRITDSPEEIVQKFRKA 197
Cdd:PTZ00126  266 AIFMEDSEEDVNRKIKKA 283
PTZ00348 PTZ00348
tyrosyl-tRNA synthetase; Provisional
 91-210 9.72e-06

tyrosyl-tRNA synthetase; Provisional


Pssm-ID: 173541 [Multi-domain]  Cd Length: 682  Bit Score: 46.82  E-value: 9.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  91 KQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYgeffpvpESILTSMKKVKSLRDPSAKM 170
Cdd:PTZ00348  151 KTEGTLTAAQVLYPLMQCADIFFLKADICQLGLDQRKVNMLAREYCDLIGRKL-------KPVILSHHMLAGLKQGQAKM 223

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1804891951 171 SKSDPDklATVRITDSPEEIVQKFRKA----VTDFTSEVTYDPA 210
Cdd:PTZ00348  224 SKSDPD--SAIFMEDTEEDVARKIRQAycprVKQSASEITDDGA 265
TyrRS_core cd00805
catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) ...
 101-197 1.44e-04

catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) catalytic core domain. TyrRS is a homodimer which attaches Tyr to the appropriate tRNA. TyrRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formationof the enzyme bound aminoacyl-adenylate. It contains the class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173902 [Multi-domain]  Cd Length: 269  Bit Score: 42.59  E-value: 1.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 101 LTYPVLQAADIL-LYKSTHVPvGEDQVQHMELVQDLAQGFNKK--YGEFFPvpesILTSMKkvkslrdpSAKMSKSDPDK 177
Cdd:cd00805   137 FIYPLLQAYDFVyLDVDLQLG-GSDQRGNITLGRDLIRKLGYKkvVGLTTP----LLTGLD--------GGKMSKSEGNA 203

                          90       100
                  ....*....|....*....|
gi 1804891951 178 lATVRITDSPEEIVQKFRKA 197
Cdd:cd00805   204 -IWDPVLDSPYDVYQKIRNA 222
PLN02486 PLN02486
aminoacyl-tRNA ligase
 98-196 1.54e-03

aminoacyl-tRNA ligase


Pssm-ID: 178104  Cd Length: 383  Bit Score: 39.73  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951  98 VGLLTYPVLQAA-------DILLYKSTH----VPVGEDQVQHMELVQDLAQ--GFNKK---YGEFFPvpesiltsmkkvk 161
Cdd:PLN02486  191 IGKISFPAVQAApsfpssfPHLFGGKDKlrclIPCAIDQDPYFRMTRDVAPrlGYYKPaliESRFFP------------- 257

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1804891951 162 SLRDPSAKMSKSDPDklATVRITDSPEEIVQKFRK 196
Cdd:PLN02486  258 ALQGESGKMSASDPN--SAIYVTDTPKEIKNKINK 290
tyrS TIGR00234
tyrosyl-tRNA synthetase; This tyrosyl-tRNA synthetase model starts picking up ...
 101-236 2.37e-03

tyrosyl-tRNA synthetase; This tyrosyl-tRNA synthetase model starts picking up tryptophanyl-tRNA synthetases at scores of 0 and below. The proteins found by this model have a deep split between two groups. One group contains bacterial and organellar eukaryotic examples. The other contains archaeal and cytosolic eukaryotic examples. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272976 [Multi-domain]  Cd Length: 378  Bit Score: 39.30  E-value: 2.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804891951 101 LTYPVLQAADIL-LYKSTHVPvGEDQVQHMELVQDLAQGFNKKYGEFFPVPesILTSMKKVKSLRDPSAKMSkSDPDKLA 179
Cdd:TIGR00234 164 FIYPLLQAYDFVyLNVDLQLG-GSDQWFNIRKGRDLARENLPSLQFGLTVP--LLTPADGEKMGKSLGGAVS-LDEGKYD 239

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1804891951 180 T-VRITDSPEEIVQKFRKAVTDFTSEVTYDpagragVSNIVAVHA-AVTGLSVEEVVRR 236
Cdd:TIGR00234 240 FyQKVINTPDELVKKYLKLFTFLGLEEIEQ------LVELKGPNPrEVKENLALEITKY 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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