NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1775982072|ref|NP_001363451|]
View 

mediator of RNA polymerase II transcription subunit 23 isoform j [Homo sapiens]

Protein Classification

Med23 domain-containing protein( domain architecture ID 10569018)

Med23 domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Med23 pfam11573
Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator ...
 1-1250 0e+00

Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator complex that regulates RNA polymerase II activity. Med23 is required for heat-shock-specific gene expression, and has been shown to mediate transcriptional activation of E1A in mice.


:

Pssm-ID: 463299  Cd Length: 1301  Bit Score: 2083.91  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072    1 METQLQSIFEEVVKTEVIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLY 80
Cdd:pfam11573    1 EVNQVKSIINEILKVEIIEEAFSGFTSNLPDDEKEKTAILRKQFNNMMSKMSEEEKESLVKELIKLVHHVAEKNRLDFLF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072   81 DCLAMAVETGLLPPRLVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQL 160
Cdd:pfam11573   81 QLLEYAVQKGIISARLVCEGLIMSEKLVLCNRLFWQECFKLIRKIIPGVDYKGVREILKYCLEKARRLPYSLSPEKVPQL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  161 LAAREVIAYILERNACLLPAYFAVTEIRKLYPEGK-LPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSG---A 236
Cdd:pfam11573  161 RALENVILYILDRNACLLPAYFIVNEIMKGYPDAKmWPHWRLAELLSNFVESFRPIAQMVSIIGRSFMLPVVEHSGyadH 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  237 ICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSE 316
Cdd:pfam11573  241 LTSPWKLDPATLKFQLKGNLPYRPELLEPQTYLLRYVLEQPYSRDMVCSMLGLQKQHKQRCKALEEQLVELMICAMERSE 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  317 TEEkfDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVM 396
Cdd:pfam11573  321 TEP--EDEPITHWLWLHLSSQLIYFVLFQFASFPNIVKSLHEKLAGRDLTRGRDHLMWVLLQFISGSIQKNPLSDFLPIL 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  397 KLFDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLRLHHEFLQQ-SLRNKS--LQMN-DY 472
Cdd:pfam11573  399 KLYDLLYPEKEPLPVPDYNKPLCTHQMAATCIWIHLLKKAQDENQKLQRPIPDTLKSHHEFLQHlVLNNDSpnLAMGsDY 478

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  473 KIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPlpgtNCMASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAH 552
Cdd:pfam11573  479 RIALLCNAYSTNTEYFSRPMPALVETILGNSKSRSP----GCNAPGPTTPLSMEFLDSLTVHSKMSLIHSIVTHVIKFAQ 554

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  553 AKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAA 632
Cdd:pfam11573  555 SKSSVALAPALVETYSRLLVYTEIESLGIKGFISQLLPTVFKSQAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSLAN 634

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  633 VAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVL-SAESEELNRALILTLARATHVtdffTGSDSIQGTW 711
Cdd:pfam11573  635 VPQTNQTQLHLCVESTALRLITGLGSSEVQPQLSRFLNEPKTFLvSQESEELNRALILTLARAIHI----TGTGTDSESW 710

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  712 CKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMSNENDIITHFSMQGSPPLFLC 791
Cdd:pfam11573  711 CKELLETIMQNTPHGWPQHTLSCFPPWLLEFFKQNNVPKENKQQLKKNVEEEYRKWTSMTNENDIIAHFSVPGTPPLFLC 790

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  792 LLWKMLLETDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCL-- 869
Cdd:pfam11573  791 LLWKMLLETDRITPIAYKVLERIGARALSAHLRKFCDYLVFEFTNSCGGQHVNKCADALNDMIWKYNIVTIDRLVLCLal 870

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  870 -------------------------------------------------------KYPEKLYFEGLAEQVDPpvqiQSPY 894
Cdd:pfam11573  871 rpqegneaqvcffiiqllllkttefrnrvqdfvkenspehwkqpnwhekhlayhrKFPEKFAPEGVAEYDSS----SNPY 946

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  895 LPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRDRAFLKRKLVHAII 974
Cdd:pfam11573  947 LPTYFGNVCLRFLPVLDIVIHRALELPPVSKSLETLLEHLGCLYKFHDRPVTYLYNTLHYYEHKLRDRPDLKRKLVSAII 1026

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  975 GSLKDNRPQGWCLSDTYLKCAMNAREENPWVPDDTYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVE 1054
Cdd:pfam11573 1027 GSLKDCRPPGWALTEAYEKYHQKSSDEQLIWLPEDYYMKLIDRMVDTMDGKTPPPFPAKDWRFNEFPNPGAHALYVTCVE 1106

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072 1055 LMALAVSGKEVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWvGYPFRLF 1134
Cdd:pfam11573 1107 LMALPVSPETVANALIDVVQKGYHLIPRNQIHLWINAIGLILTALPESYWSVLHDRIVEVLSNPELTNWTYP-CSPFELF 1185

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072 1135 DFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIG 1214
Cdd:pfam11573 1186 NFDNYHESLLENRASYILALAHAVWHHAGIGQLNPFPQFVKEKLLPHVKTEEQLLYLCHLVGPFLQRFRAERERGVLDIT 1265

                         1290      1300      1310
                   ....*....|....*....|....*....|....*.
gi 1775982072 1215 VAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTG 1250
Cdd:pfam11573 1266 KLLYELLEQVDKEGVELRYMDPICDLLYHIKYMFVG 1301
 
Name Accession Description Interval E-value
Med23 pfam11573
Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator ...
 1-1250 0e+00

Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator complex that regulates RNA polymerase II activity. Med23 is required for heat-shock-specific gene expression, and has been shown to mediate transcriptional activation of E1A in mice.


Pssm-ID: 463299  Cd Length: 1301  Bit Score: 2083.91  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072    1 METQLQSIFEEVVKTEVIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLY 80
Cdd:pfam11573    1 EVNQVKSIINEILKVEIIEEAFSGFTSNLPDDEKEKTAILRKQFNNMMSKMSEEEKESLVKELIKLVHHVAEKNRLDFLF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072   81 DCLAMAVETGLLPPRLVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQL 160
Cdd:pfam11573   81 QLLEYAVQKGIISARLVCEGLIMSEKLVLCNRLFWQECFKLIRKIIPGVDYKGVREILKYCLEKARRLPYSLSPEKVPQL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  161 LAAREVIAYILERNACLLPAYFAVTEIRKLYPEGK-LPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSG---A 236
Cdd:pfam11573  161 RALENVILYILDRNACLLPAYFIVNEIMKGYPDAKmWPHWRLAELLSNFVESFRPIAQMVSIIGRSFMLPVVEHSGyadH 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  237 ICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSE 316
Cdd:pfam11573  241 LTSPWKLDPATLKFQLKGNLPYRPELLEPQTYLLRYVLEQPYSRDMVCSMLGLQKQHKQRCKALEEQLVELMICAMERSE 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  317 TEEkfDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVM 396
Cdd:pfam11573  321 TEP--EDEPITHWLWLHLSSQLIYFVLFQFASFPNIVKSLHEKLAGRDLTRGRDHLMWVLLQFISGSIQKNPLSDFLPIL 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  397 KLFDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLRLHHEFLQQ-SLRNKS--LQMN-DY 472
Cdd:pfam11573  399 KLYDLLYPEKEPLPVPDYNKPLCTHQMAATCIWIHLLKKAQDENQKLQRPIPDTLKSHHEFLQHlVLNNDSpnLAMGsDY 478

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  473 KIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPlpgtNCMASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAH 552
Cdd:pfam11573  479 RIALLCNAYSTNTEYFSRPMPALVETILGNSKSRSP----GCNAPGPTTPLSMEFLDSLTVHSKMSLIHSIVTHVIKFAQ 554

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  553 AKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAA 632
Cdd:pfam11573  555 SKSSVALAPALVETYSRLLVYTEIESLGIKGFISQLLPTVFKSQAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSLAN 634

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  633 VAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVL-SAESEELNRALILTLARATHVtdffTGSDSIQGTW 711
Cdd:pfam11573  635 VPQTNQTQLHLCVESTALRLITGLGSSEVQPQLSRFLNEPKTFLvSQESEELNRALILTLARAIHI----TGTGTDSESW 710

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  712 CKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMSNENDIITHFSMQGSPPLFLC 791
Cdd:pfam11573  711 CKELLETIMQNTPHGWPQHTLSCFPPWLLEFFKQNNVPKENKQQLKKNVEEEYRKWTSMTNENDIIAHFSVPGTPPLFLC 790

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  792 LLWKMLLETDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCL-- 869
Cdd:pfam11573  791 LLWKMLLETDRITPIAYKVLERIGARALSAHLRKFCDYLVFEFTNSCGGQHVNKCADALNDMIWKYNIVTIDRLVLCLal 870

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  870 -------------------------------------------------------KYPEKLYFEGLAEQVDPpvqiQSPY 894
Cdd:pfam11573  871 rpqegneaqvcffiiqllllkttefrnrvqdfvkenspehwkqpnwhekhlayhrKFPEKFAPEGVAEYDSS----SNPY 946

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  895 LPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRDRAFLKRKLVHAII 974
Cdd:pfam11573  947 LPTYFGNVCLRFLPVLDIVIHRALELPPVSKSLETLLEHLGCLYKFHDRPVTYLYNTLHYYEHKLRDRPDLKRKLVSAII 1026

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  975 GSLKDNRPQGWCLSDTYLKCAMNAREENPWVPDDTYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVE 1054
Cdd:pfam11573 1027 GSLKDCRPPGWALTEAYEKYHQKSSDEQLIWLPEDYYMKLIDRMVDTMDGKTPPPFPAKDWRFNEFPNPGAHALYVTCVE 1106

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072 1055 LMALAVSGKEVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWvGYPFRLF 1134
Cdd:pfam11573 1107 LMALPVSPETVANALIDVVQKGYHLIPRNQIHLWINAIGLILTALPESYWSVLHDRIVEVLSNPELTNWTYP-CSPFELF 1185

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072 1135 DFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIG 1214
Cdd:pfam11573 1186 NFDNYHESLLENRASYILALAHAVWHHAGIGQLNPFPQFVKEKLLPHVKTEEQLLYLCHLVGPFLQRFRAERERGVLDIT 1265

                         1290      1300      1310
                   ....*....|....*....|....*....|....*.
gi 1775982072 1215 VAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTG 1250
Cdd:pfam11573 1266 KLLYELLEQVDKEGVELRYMDPICDLLYHIKYMFVG 1301
 
Name Accession Description Interval E-value
Med23 pfam11573
Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator ...
 1-1250 0e+00

Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator complex that regulates RNA polymerase II activity. Med23 is required for heat-shock-specific gene expression, and has been shown to mediate transcriptional activation of E1A in mice.


Pssm-ID: 463299  Cd Length: 1301  Bit Score: 2083.91  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072    1 METQLQSIFEEVVKTEVIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLY 80
Cdd:pfam11573    1 EVNQVKSIINEILKVEIIEEAFSGFTSNLPDDEKEKTAILRKQFNNMMSKMSEEEKESLVKELIKLVHHVAEKNRLDFLF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072   81 DCLAMAVETGLLPPRLVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQL 160
Cdd:pfam11573   81 QLLEYAVQKGIISARLVCEGLIMSEKLVLCNRLFWQECFKLIRKIIPGVDYKGVREILKYCLEKARRLPYSLSPEKVPQL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  161 LAAREVIAYILERNACLLPAYFAVTEIRKLYPEGK-LPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSG---A 236
Cdd:pfam11573  161 RALENVILYILDRNACLLPAYFIVNEIMKGYPDAKmWPHWRLAELLSNFVESFRPIAQMVSIIGRSFMLPVVEHSGyadH 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  237 ICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSE 316
Cdd:pfam11573  241 LTSPWKLDPATLKFQLKGNLPYRPELLEPQTYLLRYVLEQPYSRDMVCSMLGLQKQHKQRCKALEEQLVELMICAMERSE 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  317 TEEkfDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVM 396
Cdd:pfam11573  321 TEP--EDEPITHWLWLHLSSQLIYFVLFQFASFPNIVKSLHEKLAGRDLTRGRDHLMWVLLQFISGSIQKNPLSDFLPIL 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  397 KLFDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLRLHHEFLQQ-SLRNKS--LQMN-DY 472
Cdd:pfam11573  399 KLYDLLYPEKEPLPVPDYNKPLCTHQMAATCIWIHLLKKAQDENQKLQRPIPDTLKSHHEFLQHlVLNNDSpnLAMGsDY 478

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  473 KIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPlpgtNCMASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAH 552
Cdd:pfam11573  479 RIALLCNAYSTNTEYFSRPMPALVETILGNSKSRSP----GCNAPGPTTPLSMEFLDSLTVHSKMSLIHSIVTHVIKFAQ 554

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  553 AKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAA 632
Cdd:pfam11573  555 SKSSVALAPALVETYSRLLVYTEIESLGIKGFISQLLPTVFKSQAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSLAN 634

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  633 VAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVL-SAESEELNRALILTLARATHVtdffTGSDSIQGTW 711
Cdd:pfam11573  635 VPQTNQTQLHLCVESTALRLITGLGSSEVQPQLSRFLNEPKTFLvSQESEELNRALILTLARAIHI----TGTGTDSESW 710

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  712 CKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMSNENDIITHFSMQGSPPLFLC 791
Cdd:pfam11573  711 CKELLETIMQNTPHGWPQHTLSCFPPWLLEFFKQNNVPKENKQQLKKNVEEEYRKWTSMTNENDIIAHFSVPGTPPLFLC 790

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  792 LLWKMLLETDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCL-- 869
Cdd:pfam11573  791 LLWKMLLETDRITPIAYKVLERIGARALSAHLRKFCDYLVFEFTNSCGGQHVNKCADALNDMIWKYNIVTIDRLVLCLal 870

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  870 -------------------------------------------------------KYPEKLYFEGLAEQVDPpvqiQSPY 894
Cdd:pfam11573  871 rpqegneaqvcffiiqllllkttefrnrvqdfvkenspehwkqpnwhekhlayhrKFPEKFAPEGVAEYDSS----SNPY 946

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  895 LPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRDRAFLKRKLVHAII 974
Cdd:pfam11573  947 LPTYFGNVCLRFLPVLDIVIHRALELPPVSKSLETLLEHLGCLYKFHDRPVTYLYNTLHYYEHKLRDRPDLKRKLVSAII 1026

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072  975 GSLKDNRPQGWCLSDTYLKCAMNAREENPWVPDDTYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVE 1054
Cdd:pfam11573 1027 GSLKDCRPPGWALTEAYEKYHQKSSDEQLIWLPEDYYMKLIDRMVDTMDGKTPPPFPAKDWRFNEFPNPGAHALYVTCVE 1106

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072 1055 LMALAVSGKEVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWvGYPFRLF 1134
Cdd:pfam11573 1107 LMALPVSPETVANALIDVVQKGYHLIPRNQIHLWINAIGLILTALPESYWSVLHDRIVEVLSNPELTNWTYP-CSPFELF 1185

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775982072 1135 DFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIG 1214
Cdd:pfam11573 1186 NFDNYHESLLENRASYILALAHAVWHHAGIGQLNPFPQFVKEKLLPHVKTEEQLLYLCHLVGPFLQRFRAERERGVLDIT 1265

                         1290      1300      1310
                   ....*....|....*....|....*....|....*.
gi 1775982072 1215 VAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTG 1250
Cdd:pfam11573 1266 KLLYELLEQVDKEGVELRYMDPICDLLYHIKYMFVG 1301
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH