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Conserved domains on  [gi|1736642169|ref|NP_001361031|]
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complement factor H-related 3 isoform 2 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 23-262 1.48e-18

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 83.55  E-value: 1.48e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736642169  23 CSLPYIP------NGIYTPHRIIHRTDDEIRYECKDGFYPATRSTV-SKCTLTGWIPAPRCTLKPCDFPQ-LKYGHLyye 94
Cdd:PHA02927   21 CTIPSRPinmkfkNSVETDANANYNIGDTIEYLCLPGYRKQKMGPIyAKCTGTGWTLFNQCIKRRCPSPRdIDNGQL--- 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736642169  95 ervrPYFPVSIGKEYSYYCDDGFST--PSGSYWDYLRCTAQGWEPKVPCLR--KCVF-HYVENGESSHWENNYVQGQSVK 169
Cdd:PHA02927   98 ----DIGGVDFGSSITYSCNSGYQLigESKSYCELGSTGSMVWNPEAPICEsvKCQSpPSISNGRHNGYEDFYTDGSVVT 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736642169 170 VQCYNGYSLQNDQDIMtCTENGWSPPPKCIRInptgKCgPPPPIDNGDITSLSLPVYASLSSVEYQCQKYYLLKGSKTIT 249
Cdd:PHA02927  174 YSCNSGYSLIGNSGVL-CSGGEWSDPPTCQIV----KC-PHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSST 247

                         250
                  ....*....|....*
gi 1736642169 250 CRNG-TWS-EPPTCL 262
Cdd:PHA02927  248 CSPGnTWQpELPKCV 262
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 23-262 1.48e-18

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 83.55  E-value: 1.48e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736642169  23 CSLPYIP------NGIYTPHRIIHRTDDEIRYECKDGFYPATRSTV-SKCTLTGWIPAPRCTLKPCDFPQ-LKYGHLyye 94
Cdd:PHA02927   21 CTIPSRPinmkfkNSVETDANANYNIGDTIEYLCLPGYRKQKMGPIyAKCTGTGWTLFNQCIKRRCPSPRdIDNGQL--- 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736642169  95 ervrPYFPVSIGKEYSYYCDDGFST--PSGSYWDYLRCTAQGWEPKVPCLR--KCVF-HYVENGESSHWENNYVQGQSVK 169
Cdd:PHA02927   98 ----DIGGVDFGSSITYSCNSGYQLigESKSYCELGSTGSMVWNPEAPICEsvKCQSpPSISNGRHNGYEDFYTDGSVVT 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736642169 170 VQCYNGYSLQNDQDIMtCTENGWSPPPKCIRInptgKCgPPPPIDNGDITSLSLPVYASLSSVEYQCQKYYLLKGSKTIT 249
Cdd:PHA02927  174 YSCNSGYSLIGNSGVL-CSGGEWSDPPTCQIV----KC-PHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSST 247

                         250
                  ....*....|....*
gi 1736642169 250 CRNG-TWS-EPPTCL 262
Cdd:PHA02927  248 CSPGnTWQpELPKCV 262
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 207-261 6.05e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 57.09  E-value: 6.05e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1736642169 207 CGPPPPIDNGDITSlSLPVYASLSSVEYQCQKYYLLKGSKTITCR-NGTWS-EPPTC 261
Cdd:cd00033     1 CPPPPVPENGTVTG-SKGSYSYGSTVTYSCNEGYTLVGSSTITCTeNGGWSpPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 207-261 6.52e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 51.37  E-value: 6.52e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1736642169  207 CGPPPPIDNGDITSLSlPVYASLSSVEYQCQKYYLLKGSKTITCR-NGTWS-EPPTC 261
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDPGYTLIGSSTITCLeNGTWSpPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
207-261 5.82e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 45.95  E-value: 5.82e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1736642169 207 CGPPPPIDNGDITSLSlPVYASLSSVEYQCQKYYLLKGSKTITCR-NGTWS-EPPTC 261
Cdd:pfam00084   1 CPPPPDIPNGKVSATK-NEYNYGASVSYECDPGYRLVGSPTITCQeDGTWSpPFPEC 56
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 23-262 1.48e-18

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 83.55  E-value: 1.48e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736642169  23 CSLPYIP------NGIYTPHRIIHRTDDEIRYECKDGFYPATRSTV-SKCTLTGWIPAPRCTLKPCDFPQ-LKYGHLyye 94
Cdd:PHA02927   21 CTIPSRPinmkfkNSVETDANANYNIGDTIEYLCLPGYRKQKMGPIyAKCTGTGWTLFNQCIKRRCPSPRdIDNGQL--- 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736642169  95 ervrPYFPVSIGKEYSYYCDDGFST--PSGSYWDYLRCTAQGWEPKVPCLR--KCVF-HYVENGESSHWENNYVQGQSVK 169
Cdd:PHA02927   98 ----DIGGVDFGSSITYSCNSGYQLigESKSYCELGSTGSMVWNPEAPICEsvKCQSpPSISNGRHNGYEDFYTDGSVVT 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736642169 170 VQCYNGYSLQNDQDIMtCTENGWSPPPKCIRInptgKCgPPPPIDNGDITSLSLPVYASLSSVEYQCQKYYLLKGSKTIT 249
Cdd:PHA02927  174 YSCNSGYSLIGNSGVL-CSGGEWSDPPTCQIV----KC-PHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSST 247

                         250
                  ....*....|....*
gi 1736642169 250 CRNG-TWS-EPPTCL 262
Cdd:PHA02927  248 CSPGnTWQpELPKCV 262
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 207-261 6.05e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 57.09  E-value: 6.05e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1736642169 207 CGPPPPIDNGDITSlSLPVYASLSSVEYQCQKYYLLKGSKTITCR-NGTWS-EPPTC 261
Cdd:cd00033     1 CPPPPVPENGTVTG-SKGSYSYGSTVTYSCNEGYTLVGSSTITCTeNGGWSpPPPTC 56
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 104-327 3.88e-10

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 59.67  E-value: 3.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736642169 104 SIGKEYSYYCDDGFSTPS-GSYwdYLRCTAQGWEPKVPCL-RKCVF-HYVENGESSHWENNYvqGQSVKVQCYNGYSLQN 180
Cdd:PHA02927   45 NIGDTIEYLCLPGYRKQKmGPI--YAKCTGTGWTLFNQCIkRRCPSpRDIDNGQLDIGGVDF--GSSITYSCNSGYQLIG 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736642169 181 DQ----DIMTCTENGWSP-PPKCIRInptgKCGPPPPIDNGDITSLSlPVYASLSSVEYQCQKYYLLKGSKTITCRNGTW 255
Cdd:PHA02927  121 ESksycELGSTGSMVWNPeAPICESV----KCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSGYSLIGNSGVLCSGGEW 195

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1736642169 256 SEPPTCLSACIISEDILERHnILLKWKQSqkvYSQSgDVIEFVCKPGYRQARKSPSFRAKCMNGDINYPTCV 327
Cdd:PHA02927  196 SDPPTCQIVKCPHPTISNGY-LSSGFKRS---YSYN-DNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKCV 262
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 207-261 6.52e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 51.37  E-value: 6.52e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1736642169  207 CGPPPPIDNGDITSLSlPVYASLSSVEYQCQKYYLLKGSKTITCR-NGTWS-EPPTC 261
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDPGYTLIGSSTITCLeNGTWSpPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
207-261 5.82e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 45.95  E-value: 5.82e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1736642169 207 CGPPPPIDNGDITSLSlPVYASLSSVEYQCQKYYLLKGSKTITCR-NGTWS-EPPTC 261
Cdd:pfam00084   1 CPPPPDIPNGKVSATK-NEYNYGASVSYECDPGYRLVGSPTITCQeDGTWSpPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 150-199 3.73e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 43.61  E-value: 3.73e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1736642169 150 VENGESSHWENNYVQGQSVKVQCYNGYSLQNdQDIMTCTENG-WSP-PPKCI 199
Cdd:cd00033     7 PENGTVTGSKGSYSYGSTVTYSCNEGYTLVG-SSTITCTENGgWSPpPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 150-198 1.12e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 42.13  E-value: 1.12e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1736642169  150 VENGESSHWENNYVQGQSVKVQCYNGYSLQNDqDIMTCTENG-WSPP-PKC 198
Cdd:smart00032   7 IENGTVTSSSGTYSYGDTVTYSCDPGYTLIGS-STITCLENGtWSPPpPTC 56
PHA02831 PHA02831
EEV host range protein; Provisional
 156-327 3.65e-05

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 44.60  E-value: 3.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736642169 156 SHWENNYVQGQSVKVQCYNGYslqnDQDIMTCTENGWSPPPKCIrinptGK--CGPPPPIDNGDITSlSLPVYASLSSVE 233
Cdd:PHA02831   34 SYENKVYEENENLEYKCNNNF----DKVFVTCNNGSWSTKNMCI-----GKrnCKDPVTILNGYIKN-KKDQYSFGDSVT 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736642169 234 YQCQ----KYYLLKGSKTITCRNGTW-SEPPTCLsacIISEDILERHNILLKWKQSQKVYsqsGDVIEFVCKPGYRQark 308
Cdd:PHA02831  104 YACKvnklEKYSIVGNETVKCINKQWvPKYPVCK---LIRCKYPALQNGFLNVFEKKFYY---GDIVNFKCKKGFIL--- 174

                         170       180
                  ....*....|....*....|....*
gi 1736642169 309 SPSFRAKCmngDINY------PTCV 327
Cdd:PHA02831  175 LGSSVSTC---DINSiwypgiPKCV 196
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 22-262 1.28e-04

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 43.15  E-value: 1.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736642169  22 TCSLPYIPNGIYTPHRIIHRTDDEIRYECKDGFYPATRSTVskCTLTGWIPAPRCTlKPC---DFPQLKYGHLYYEerVR 98
Cdd:PHA02954   20 TCTVPTMNNAKLTSTETSFNDKQKVTFTCDSGYYSLDPNAV--CETDKWKYENPCK-KMCtvsDYVSELYDKPLYE--VN 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736642169  99 PYFPVSIGKEYSYY-CDDGFSTPSgsywdylrctaqgWEPKVPCLR-KCVFHYVENGESSHWENNYVQGQSVKVQCYNGY 176
Cdd:PHA02954   95 STITLICKDETKYFrCEEKNGNTS-------------WNDTVTCPNaECQPLQLEHGSCQPVKEKYSFGEHITINCDVGY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736642169 177 SLQNDQDImTCTENGWSPPPKCIRinptgKCGpPPPIDNGDITSLSLPVYAslsSVEYQCQKYYLLKGSKTITCRNGTWS 256
Cdd:PHA02954  162 EVIGASYI-SCTANSWNVIPSCQQ-----KCD-IPSLSNGLISGSTFSIGG---VIHLSCKSGFTLTGSPSSTCIDGKWN 231


                  ....*..
gi 1736642169 257 EP-PTCL 262
Cdd:PHA02954  232 PVlPICV 238
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 25-76 1.91e-03

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 35.97  E-value: 1.91e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1736642169   25 LPYIPNGIYTPHRIIHRTDDEIRYECKDGFYPaTRSTVSKCTLTG-W-IPAPRC 76
Cdd:smart00032   4 PPDIENGTVTSSSGTYSYGDTVTYSCDPGYTL-IGSSTITCLENGtWsPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
150-198 2.23e-03

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 35.94  E-value: 2.23e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1736642169 150 VENGESSHWENNYVQGQSVKVQCYNGYSLQnDQDIMTCTENG-WSPP-PKC 198
Cdd:pfam00084   7 IPNGKVSATKNEYNYGASVSYECDPGYRLV-GSPTITCQEDGtWSPPfPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 23-76 3.80e-03

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 35.13  E-value: 3.80e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1736642169  23 CSLPYIP-NGIYTPHRIIHRTDDEIRYECKDGFYPaTRSTVSKCTLTG-WIP-APRC 76
Cdd:cd00033     1 CPPPPVPeNGTVTGSKGSYSYGSTVTYSCNEGYTL-VGSSTITCTENGgWSPpPPTC 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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