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Conserved domains on  [gi|1666305212|ref|NP_001357666|]
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transmembrane and coiled-coil domain-containing protein 5A isoform 4 [Homo sapiens]

Protein Classification

TMCO5 domain-containing protein( domain architecture ID 12171749)

TMCO5 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMCO5 pfam14992
TMCO5 family; The TMCO5 family includes human transmembrane and coiled-coil domain-containing ...
 13-223 2.98e-96

TMCO5 family; The TMCO5 family includes human transmembrane and coiled-coil domain-containing proteins 5A and 5B.


:

Pssm-ID: 464427 [Multi-domain]  Cd Length: 278  Bit Score: 285.07  E-value: 2.98e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212  13 IISLNMDLERDTQRIDEANQKLLLKIQEREDKIQRLESEIIQTRGLVEDEEWEKENRTTMERERALQELEEETARLERKN 92
Cdd:pfam14992   1 LNSLNSDLEKDLQRLDEANQVLLLKIQEKEEEIQSLEREITLTRSLAEDEEREELNFTIMEKEDALQELELETAKLEKKN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212  93 KTLVHSITELQQKLTRKSQKITNCEQSSPDGALEETKVKLQQLEASYACQEKELLKVMKEYAFVTQLCEDQALYIKKYQE 172
Cdd:pfam14992  81 EILVKSVMELQRKLSRKSDKNTGLEQETLKQMLEELKVKLQQSEESCADQEKELAKVESDYQSVHQLCEDQALCIKKYQE 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1666305212 173 TLKKIEEELEALFLEREVSKLVSMNPVEK---EHTSQNNEGTPTQKTARLFSKK 223
Cdd:pfam14992 161 ILRKMEEEKETRLLEKEVSKAQSNSSQRVklvETIQQNMEKTIIKKQKRIFWKR 214
 
Name Accession Description Interval E-value
TMCO5 pfam14992
TMCO5 family; The TMCO5 family includes human transmembrane and coiled-coil domain-containing ...
 13-223 2.98e-96

TMCO5 family; The TMCO5 family includes human transmembrane and coiled-coil domain-containing proteins 5A and 5B.


Pssm-ID: 464427 [Multi-domain]  Cd Length: 278  Bit Score: 285.07  E-value: 2.98e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212  13 IISLNMDLERDTQRIDEANQKLLLKIQEREDKIQRLESEIIQTRGLVEDEEWEKENRTTMERERALQELEEETARLERKN 92
Cdd:pfam14992   1 LNSLNSDLEKDLQRLDEANQVLLLKIQEKEEEIQSLEREITLTRSLAEDEEREELNFTIMEKEDALQELELETAKLEKKN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212  93 KTLVHSITELQQKLTRKSQKITNCEQSSPDGALEETKVKLQQLEASYACQEKELLKVMKEYAFVTQLCEDQALYIKKYQE 172
Cdd:pfam14992  81 EILVKSVMELQRKLSRKSDKNTGLEQETLKQMLEELKVKLQQSEESCADQEKELAKVESDYQSVHQLCEDQALCIKKYQE 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1666305212 173 TLKKIEEELEALFLEREVSKLVSMNPVEK---EHTSQNNEGTPTQKTARLFSKK 223
Cdd:pfam14992 161 ILRKMEEEKETRLLEKEVSKAQSNSSQRVklvETIQQNMEKTIIKKQKRIFWKR 214
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
19-108 4.38e-06

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 47.93  E-value: 4.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212  19 DLERDTQRIDEANQKLLLKIQEREDKIQRLESEIIQTRglvedeeweKENRTTMERERALQELEEETARLERKNKTLVHS 98
Cdd:COG2433   417 RLEEQVERLEAEVEELEAELEEKDERIERLERELSEAR---------SEERREIRKDREISRLDREIERLERELEEERER 487

                          90
                  ....*....|
gi 1666305212  99 ITELQQKLTR 108
Cdd:COG2433   488 IEELKRKLER 497
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 5-158 5.36e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 44.66  E-value: 5.36e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212    5 RLAQSKRNIISLNMDLERDTQRIDEANQKLLL---KIQEREDKIQRLESEIIQTRGLVE---------DEEWEKENRTTM 72
Cdd:TIGR02168  310 RLANLERQLEELEAQLEELESKLDELAEELAEleeKLEELKEELESLEAELEELEAELEelesrleelEEQLETLRSKVA 389

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212   73 ERERALQELEEETARLERKNKTLVHSITELQQKLTRKSQKITNCEQSSPDGALEETKVKLQQLEASYACQEKELLKVMKE 152
Cdd:TIGR02168  390 QLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREE 469


                   ....*.
gi 1666305212  153 YAFVTQ 158
Cdd:TIGR02168  470 LEEAEQ 475
PRK12704 PRK12704
phosphodiesterase; Provisional
 25-172 7.15e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 37.84  E-value: 7.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212  25 QRIDEANQKLLLKIQEREDKIQRLESEIIQtrglvEDEEWEKENRTTMERERALQELEEETARLERKNKTLVHSITELQQ 104
Cdd:PRK12704   64 EEIHKLRNEFEKELRERRNELQKLEKRLLQ-----KEENLDRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIE 138

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1666305212 105 KLTRKSQKITNceqsspdgaleetkvkLQQLEAsyacqEKELLKVMKEyafvtQLCEDQALYIKKYQE 172
Cdd:PRK12704  139 EQLQELERISG----------------LTAEEA-----KEILLEKVEE-----EARHEAAVLIKEIEE 180
 
Name Accession Description Interval E-value
TMCO5 pfam14992
TMCO5 family; The TMCO5 family includes human transmembrane and coiled-coil domain-containing ...
 13-223 2.98e-96

TMCO5 family; The TMCO5 family includes human transmembrane and coiled-coil domain-containing proteins 5A and 5B.


Pssm-ID: 464427 [Multi-domain]  Cd Length: 278  Bit Score: 285.07  E-value: 2.98e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212  13 IISLNMDLERDTQRIDEANQKLLLKIQEREDKIQRLESEIIQTRGLVEDEEWEKENRTTMERERALQELEEETARLERKN 92
Cdd:pfam14992   1 LNSLNSDLEKDLQRLDEANQVLLLKIQEKEEEIQSLEREITLTRSLAEDEEREELNFTIMEKEDALQELELETAKLEKKN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212  93 KTLVHSITELQQKLTRKSQKITNCEQSSPDGALEETKVKLQQLEASYACQEKELLKVMKEYAFVTQLCEDQALYIKKYQE 172
Cdd:pfam14992  81 EILVKSVMELQRKLSRKSDKNTGLEQETLKQMLEELKVKLQQSEESCADQEKELAKVESDYQSVHQLCEDQALCIKKYQE 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1666305212 173 TLKKIEEELEALFLEREVSKLVSMNPVEK---EHTSQNNEGTPTQKTARLFSKK 223
Cdd:pfam14992 161 ILRKMEEEKETRLLEKEVSKAQSNSSQRVklvETIQQNMEKTIIKKQKRIFWKR 214
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
19-108 4.38e-06

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 47.93  E-value: 4.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212  19 DLERDTQRIDEANQKLLLKIQEREDKIQRLESEIIQTRglvedeeweKENRTTMERERALQELEEETARLERKNKTLVHS 98
Cdd:COG2433   417 RLEEQVERLEAEVEELEAELEEKDERIERLERELSEAR---------SEERREIRKDREISRLDREIERLERELEEERER 487

                          90
                  ....*....|
gi 1666305212  99 ITELQQKLTR 108
Cdd:COG2433   488 IEELKRKLER 497
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 5-158 5.36e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 44.66  E-value: 5.36e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212    5 RLAQSKRNIISLNMDLERDTQRIDEANQKLLL---KIQEREDKIQRLESEIIQTRGLVE---------DEEWEKENRTTM 72
Cdd:TIGR02168  310 RLANLERQLEELEAQLEELESKLDELAEELAEleeKLEELKEELESLEAELEELEAELEelesrleelEEQLETLRSKVA 389

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212   73 ERERALQELEEETARLERKNKTLVHSITELQQKLTRKSQKITNCEQSSPDGALEETKVKLQQLEASYACQEKELLKVMKE 152
Cdd:TIGR02168  390 QLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREE 469


                   ....*.
gi 1666305212  153 YAFVTQ 158
Cdd:TIGR02168  470 LEEAEQ 475
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
2-116 5.54e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 44.52  E-value: 5.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212    2 EISRLAQSKRNIISLNMDLERDTQRIDEANQK---LLLKIQEREDKIQRLESEIIQTRGLVEDEEWEKENRTTMERERAL 78
Cdd:COG4913    669 EIAELEAELERLDASSDDLAALEEQLEELEAEleeLEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELR 748

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1666305212   79 QELEE------ETARLERKNKTLVHSITELQQKLTRKSQKITNC 116
Cdd:COG4913    749 ALLEErfaaalGDAVERELRENLEERIDALRARLNRAEEELERA 792
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
15-135 9.14e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 43.99  E-value: 9.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212  15 SLNMDLERDTQRIDEANQKLLlKIQEREDKIQRLESEIIQTRGLVEdeewEKENRTTMERERALQELEEETARLERKNKT 94
Cdd:COG4717   136 ALEAELAELPERLEELEERLE-ELRELEEELEELEAELAELQEELE----ELLEQLSLATEEELQDLAEELEELQQRLAE 210

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1666305212  95 LVHSITELQQKLTRKSQKITNCEQSSPDGALEETKVKLQQL 135
Cdd:COG4717   211 LEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLL 251
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 19-154 3.05e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 42.23  E-value: 3.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212  19 DLERDTQRIDEANQKLLLKIQEREDKIQRLESEIIQTRGLVEDEEWEKENRTTMERE--RALQELEEETARLERKNKTLV 96
Cdd:COG1196   236 ELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYEllAELARLEQDIARLEERRRELE 315

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1666305212  97 HSITELQQKLTRKSQKITNCEQsspdgALEETKVKLQQLEASYACQEKELLKVMKEYA 154
Cdd:COG1196   316 ERLEELEEELAELEEELEELEE-----ELEELEEELEEAEEELEEAEAELAEAEEALL 368
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
8-177 3.55e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 41.93  E-value: 3.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212   8 QSKRNIISLNMDLERDTQRIDEANQKLL---LKIQEREDKIQRLESEIIQTRGLVEDEEWEKENRTTMERERALQ-ELEE 83
Cdd:COG3206   202 RQKNGLVDLSEEAKLLLQQLSELESQLAearAELAEAEARLAALRAQLGSGPDALPELLQSPVIQQLRAQLAELEaELAE 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212  84 ETARLERKN---KTLVHSITELQQKLTRKSQKITNCEQSspdgALEETKVKLQQLEASYACQEKELLKVMKEYAFVTQLC 160
Cdd:COG3206   282 LSARYTPNHpdvIALRAQIAALRAQLQQEAQRILASLEA----ELEALQAREASLQAQLAQLEARLAELPELEAELRRLE 357

                         170
                  ....*....|....*..
gi 1666305212 161 EDQALYIKKYQETLKKI 177
Cdd:COG3206   358 REVEVARELYESLLQRL 374
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 34-154 7.56e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.08  E-value: 7.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212  34 LLLKIQEREDKIQRLESEIIQTRGLVEDEEWEKENRTTmERERALQELEEETARLERKNKT---LVHSITELQQKLTRKS 110
Cdd:COG1196   230 LLLKLRELEAELEELEAELEELEAELEELEAELAELEA-ELEELRLELEELELELEEAQAEeyeLLAELARLEQDIARLE 308

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1666305212 111 QKITNCEQsspdgALEETKVKLQQLEASYACQEKELLKVMKEYA 154
Cdd:COG1196   309 ERRRELEE-----RLEELEEELAELEEELEELEEELEELEEELE 347
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 5-175 1.02e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.82  E-value: 1.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212    5 RLAQSKRNIISLNMDLERDTQRIDEAN---QKLLLKIQEREDKIQRLESEIIQTRGLVEDEEWEKENRTTMERERALQEL 81
Cdd:TIGR02169  738 RLEELEEDLSSLEQEIENVKSELKELEariEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKLEEEVSRIEARLREI 817

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212   82 EEETARLERKNKTLVHSITELQQKLTR-KSQKITNCEQ--------SSPDGALEETKVKLQQLEASYACQEKELLKVMKE 152
Cdd:TIGR02169  818 EQKLNRLTLEKEYLEKEIQELQEQRIDlKEQIKSIEKEienlngkkEELEEELEELEAALRDLESRLGDLKKERDELEAQ 897

                          170       180
                   ....*....|....*....|...
gi 1666305212  153 YAFVTQLCEDQALYIKKYQETLK 175
Cdd:TIGR02169  898 LRELERKIEELEAQIEKKRKRLS 920
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1-137 1.25e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 40.49  E-value: 1.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212   1 MEISRLAQSKRniisLNMDLERDTQRID---EANQKLLLKIQEREDKIQRLESEIIQTRGLVEDEEWEKENRTTMERERA 77
Cdd:pfam17380 372 MEISRMRELER----LQMERQQKNERVRqelEAARKVKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEERARE 447

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1666305212  78 LQELEEEtaRLERKnktlvHSITELQQKLTRKSQKITNCEQSSPDGALEET---KVKLQQLEA 137
Cdd:pfam17380 448 MERVRLE--EQERQ-----QQVERLRQQEEERKRKKLELEKEKRDRKRAEEqrrKILEKELEE 503
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 3-172 1.30e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 40.20  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212   3 ISRLAQSKRNIISLNMDLERDTQRIDEANQKlllkIQEREDKIQRLESEIIQTRGLVED--EEWEKENRTTMERERALQE 80
Cdd:COG3883    29 QAELEAAQAELDALQAELEELNEEYNELQAE----LEALQAEIDKLQAEIAEAEAEIEErrEELGERARALYRSGGSVSY 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212  81 LE---------------EETARLERKNKTLVHSITELQQKLTRKSQKitnceqsspdgaLEETKVKLQQLEASYACQEKE 145
Cdd:COG3883   105 LDvllgsesfsdfldrlSALSKIADADADLLEELKADKAELEAKKAE------------LEAKLAELEALKAELEAAKAE 172

                         170       180
                  ....*....|....*....|....*...
gi 1666305212 146 LLKVMKEY-AFVTQLCEDQALYIKKYQE 172
Cdd:COG3883   173 LEAQQAEQeALLAQLSAEEAAAEAQLAE 200
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 2-146 1.32e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.44  E-value: 1.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212    2 EISRLAQSKRNIISLNMDLERDTQRIDEANQKLLLKIQ-------EREDKI--QRLESEIIQTRGLVEDEEWEKENRTTM 72
Cdd:TIGR02169  161 EIAGVAEFDRKKEKALEELEEVEENIERLDLIIDEKRQqlerlrrEREKAEryQALLKEKREYEGYELLKEKEALERQKE 240

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1666305212   73 ERERALQELEEE----TARLERKNKTLvHSITELQQKLTRKSQKITNCEQSSPDGALEETKVKLQQLEASYACQEKEL 146
Cdd:TIGR02169  241 AIERQLASLEEEleklTEEISELEKRL-EEIEQLLEELNKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKEREL 317
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 5-175 1.48e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.31  E-value: 1.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212   5 RLAQSKRNIISLNMDLERDTQRIDEANQKLL---LKIQEREDKIQRLESEIIQtrgLVEDEEWEKENRTtmERERALQEL 81
Cdd:COG1196   247 ELEELEAELEELEAELAELEAELEELRLELEeleLELEEAQAEEYELLAELAR---LEQDIARLEERRR--ELEERLEEL 321

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212  82 EEETARLERKNKTLVHSITELQQKLTRKSQKITNCEQsspdgALEETKVKLQQLEASYACQEKELLKVMKEYAFVTQLCE 161
Cdd:COG1196   322 EEELAELEEELEELEEELEELEEELEEAEEELEEAEA-----ELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAA 396

                         170
                  ....*....|....
gi 1666305212 162 DQALYIKKYQETLK 175
Cdd:COG1196   397 ELAAQLEELEEAEE 410
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 4-154 1.49e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 39.75  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212   4 SRLAQSKRNIISLNMDLERDTQRIDEANQKLLL---KIQEREDKIQRLESEIIQTRG----------------------- 57
Cdd:COG4942    41 KELAALKKEEKALLKQLAALERRIAALARRIRAleqELAALEAELAELEKEIAELRAeleaqkeelaellralyrlgrqp 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212  58 ----LVEDEEWEKENRTTM-------ERERALQELEEETARLERKNKTLVHSITELQQKLTRKSQKITNCEQsspdgALE 126
Cdd:COG4942   121 plalLLSPEDFLDAVRRLQylkylapARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEA-----LKA 195

                         170       180
                  ....*....|....*....|....*...
gi 1666305212 127 ETKVKLQQLEASYACQEKELLKVMKEYA 154
Cdd:COG4942   196 ERQKLLARLEKELAELAAELAELQQEAE 223
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 34-149 1.53e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 40.04  E-value: 1.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212   34 LLLKIQEREDKIQRLESEIIQTRGLVEDEEwekenrttmereRALQELEEETARLERKNKTLVHSITELQQKLTRKSQKI 113
Cdd:TIGR02168  230 LVLRLEELREELEELQEELKEAEEELEELT------------AELQELEEKLEELRLEVSELEEEIEELQKELYALANEI 297

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1666305212  114 TNCEQSspdgaLEETKVKLQQLEASYACQEKELLKV 149
Cdd:TIGR02168  298 SRLEQQ-----KQILRERLANLERQLEELEAQLEEL 328
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 4-152 1.62e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 39.14  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212   4 SRLAQSKRNIISLNMDLERDTQRIDEANQKLLLKIQERED---KIQRLESEIIQTRGLVEDEEwEKENRTTMEREraLQE 80
Cdd:COG1579    17 SELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDlekEIKRLELEIEEVEARIKKYE-EQLGNVRNNKE--YEA 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1666305212  81 LEEETARLERKNKTLVHSITELQQKLTRKSQKITNCEQsspdgALEETKVKLQQLEASYACQEKELLKVMKE 152
Cdd:COG1579    94 LQKEIESLKRRISDLEDEILELMERIEELEEELAELEA-----ELAELEAELEEKKAELDEELAELEAELEE 160
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2-146 2.13e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.53  E-value: 2.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212   2 EISRLAQSKRNIISLNMDLERDTQRIDEANQKLLL---KIQEREDKIQRLESEIIQTRGLVEDEEWEKENRTTM--ERER 76
Cdd:COG1196   258 LEAELAELEAELEELRLELEELELELEEAQAEEYEllaELARLEQDIARLEERRRELEERLEELEEELAELEEEleELEE 337

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212  77 ALQELEEETARLERKNKTLVHSITELQQKLTRKSQKITNCEQSspdgALEETKVKLQQLEASYACQEKEL 146
Cdd:COG1196   338 ELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEE----LEELAEELLEALRAAAELAAQLE 403
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 4-154 2.16e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 39.67  E-value: 2.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212    4 SRLAQSKRNIISLNMDLERDTQRIDEANQK---LLLKIQEREDKIQRLESEIIQTRGLVED--EEWEKENRTTMERERAL 78
Cdd:TIGR02169  336 AEIEELEREIEEERKRRDKLTEEYAELKEEledLRAELEEVDKEFAETRDELKDYREKLEKlkREINELKRELDRLQEEL 415

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1666305212   79 QELEEETARLERKNKTLVHSITELQQKLTRKSQKITNCEQ--SSPDGALEETKVKLQQLEASYACQEKELLKVMKEYA 154
Cdd:TIGR02169  416 QRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWklEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELA 493
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2-152 4.59e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 38.50  E-value: 4.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212    2 EISRLAQSKRNIISLNMDLERDTQRIDEANQKLLLKIQEREDKIQRLESEI--IQTRGLVEDEEWEKENRTTMERERALQ 79
Cdd:TIGR02168  706 ELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELteLEAEIEELEERLEEAEEELAEAEAEIE 785

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1666305212   80 ELEEETARLERKNKTLVHSITELQQKLTRKSQKITNCEQ--SSPDGALEETKVKLQQLEASYACQEKELLKVMKE 152
Cdd:TIGR02168  786 ELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRErlESLERRIAATERRLEDLEEQIEELSEDIESLAAE 860
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 24-113 5.05e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 38.21  E-value: 5.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212  24 TQRIDEANQKLllkiQEREDKIQRLESEIIQTRGLVED--EEWEKENRTTMERERALQELEEETARLERKNKTLVHSITE 101
Cdd:COG4942    19 ADAAAEAEAEL----EQLQQEIAELEKELAALKKEEKAllKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAE 94

                          90
                  ....*....|..
gi 1666305212 102 LQQKLTRKSQKI 113
Cdd:COG4942    95 LRAELEAQKEEL 106
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 28-106 6.47e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 37.21  E-value: 6.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212  28 DEANQKLLLKIQEREDKIQRLESEIIQTRGLVED--EEWEKENRTTMERERALQELEEETARLERKNKTLVHSITELQQK 105
Cdd:COG1579     2 MPEDLRALLDLQELDSELDRLEHRLKELPAELAEleDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQ 81


                  .
gi 1666305212 106 L 106
Cdd:COG1579    82 L 82
PRK12704 PRK12704
phosphodiesterase; Provisional
 25-172 7.15e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 37.84  E-value: 7.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305212  25 QRIDEANQKLLLKIQEREDKIQRLESEIIQtrglvEDEEWEKENRTTMERERALQELEEETARLERKNKTLVHSITELQQ 104
Cdd:PRK12704   64 EEIHKLRNEFEKELRERRNELQKLEKRLLQ-----KEENLDRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIE 138

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1666305212 105 KLTRKSQKITNceqsspdgaleetkvkLQQLEAsyacqEKELLKVMKEyafvtQLCEDQALYIKKYQE 172
Cdd:PRK12704  139 EQLQELERISG----------------LTAEEA-----KEILLEKVEE-----EARHEAAVLIKEIEE 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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