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Conserved domains on  [gi|1620863302|ref|NP_001356691|]
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zinc finger protein 28 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
300-661 1.11e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 1.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 300 KPYKCNECGKVFNRLSTLARHRRLHTGEKPYEC--EECEKVFSRKSHLERHKRIHTGEKPYKCkvCDKAFAYNSYLAKHS 377
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 378 IIHTGE---KPYKCNECGKVFNQQSTLARHHRLHTAEKPYKCEEC-----------DKVFRCKSHLER-----------H 432
Cdd:COG5048   110 LSSSSSnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnSLHPPLPANSLSkdpssnlslliS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 433 RRIHTGEKPYKCKVCDKAFRSDSCLTEHQRVHTGEKPYMCNECGKVFSTKA------NLACHHKLHTAEKPYKCEECEKV 506
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLlsqspsSLSSSDSSSSASESPRSSLPTAS 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 507 FSRKSHMERHRRIHTG-EKPYKCKVCDKAFRRDSHLAQHQR--VHTGE--KPYKCNE--CGKTFRQTSSLIIHRRLHTGE 579
Cdd:COG5048   270 SQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 580 KPYKCNECGKTFSQMSSL-------VYHHRLHSGEKPYKC--NECGKVFNQQAHLAQHQRVHTGEKP--YKCNECGKTFS 648
Cdd:COG5048   350 SPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFN 429

                         410
                  ....*....|...
gi 1620863302 649 QMSNLVYHHRLHS 661
Cdd:COG5048   430 RHYNLIPHKKIHT 442
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 211-321 1.39e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 211 SHIDEKPYKCNECGKIFGHNTSLFLH---KALHTAD-KPYECE--ECDKVFSRKSHLETHKiiytggkpyKCKVCDKAFT 284
Cdd:COG5189   311 IDVRKLPCTNSSSNGKLAHGGERNIDtpsRMLKVKDgKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLH 381

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1620863302 285 CNSYLAKHTIIHTGEKPYKCNECGKVFNRLSTLARHR 321
Cdd:COG5189   382 ENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
96-320 6.39e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 6.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302  96 PELHIFQPEGKIGNQVEKSINNASSVSTSQRICCRPKTHiSNKYGNNSLHSSLLTQKRNVHMREKSFQCIESGKSFNCSS 175
Cdd:COG5048   231 TNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS-SQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHL 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 176 LLKKHQITHLEEKQCKCDVYGKVFNQKRYLACHRRSHIDEKPYKC--NECGKIFGH-----NTSLFLHKALHTADKPYEC 248
Cdd:COG5048   310 RSVNHSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPllnnePPQSLQQYKDLKNDKKSET 389

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1620863302 249 E--ECDKVFSRKSHLETHKI--IYTGGKPYKCKVCDKAFTCNSYLAKHTIIHTgEKPYKCNECGKVFNRLSTLARH 320
Cdd:COG5048   390 LsnSCIRNFKRDSNLSLHIIthLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
300-661 1.11e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 1.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 300 KPYKCNECGKVFNRLSTLARHRRLHTGEKPYEC--EECEKVFSRKSHLERHKRIHTGEKPYKCkvCDKAFAYNSYLAKHS 377
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 378 IIHTGE---KPYKCNECGKVFNQQSTLARHHRLHTAEKPYKCEEC-----------DKVFRCKSHLER-----------H 432
Cdd:COG5048   110 LSSSSSnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnSLHPPLPANSLSkdpssnlslliS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 433 RRIHTGEKPYKCKVCDKAFRSDSCLTEHQRVHTGEKPYMCNECGKVFSTKA------NLACHHKLHTAEKPYKCEECEKV 506
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLlsqspsSLSSSDSSSSASESPRSSLPTAS 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 507 FSRKSHMERHRRIHTG-EKPYKCKVCDKAFRRDSHLAQHQR--VHTGE--KPYKCNE--CGKTFRQTSSLIIHRRLHTGE 579
Cdd:COG5048   270 SQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 580 KPYKCNECGKTFSQMSSL-------VYHHRLHSGEKPYKC--NECGKVFNQQAHLAQHQRVHTGEKP--YKCNECGKTFS 648
Cdd:COG5048   350 SPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFN 429

                         410
                  ....*....|...
gi 1620863302 649 QMSNLVYHHRLHS 661
Cdd:COG5048   430 RHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
344-369 1.01e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.01e-04
                          10        20
                  ....*....|....*....|....*.
gi 1620863302 344 HLERHKRIHTGEKPYKCKVCDKAFAY 369
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 524-572 1.04e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.31  E-value: 1.04e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1620863302 524 KPYkCKVCDKAFRRDSHLAQHQRvhtgEKPYKCNECGKTFRQTSSLIIH 572
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVH 44
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 211-321 1.39e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 211 SHIDEKPYKCNECGKIFGHNTSLFLH---KALHTAD-KPYECE--ECDKVFSRKSHLETHKiiytggkpyKCKVCDKAFT 284
Cdd:COG5189   311 IDVRKLPCTNSSSNGKLAHGGERNIDtpsRMLKVKDgKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLH 381

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1620863302 285 CNSYLAKHTIIHTGEKPYKCNECGKVFNRLSTLARHR 321
Cdd:COG5189   382 ENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
96-320 6.39e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 6.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302  96 PELHIFQPEGKIGNQVEKSINNASSVSTSQRICCRPKTHiSNKYGNNSLHSSLLTQKRNVHMREKSFQCIESGKSFNCSS 175
Cdd:COG5048   231 TNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS-SQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHL 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 176 LLKKHQITHLEEKQCKCDVYGKVFNQKRYLACHRRSHIDEKPYKC--NECGKIFGH-----NTSLFLHKALHTADKPYEC 248
Cdd:COG5048   310 RSVNHSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPllnnePPQSLQQYKDLKNDKKSET 389

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1620863302 249 E--ECDKVFSRKSHLETHKI--IYTGGKPYKCKVCDKAFTCNSYLAKHTIIHTgEKPYKCNECGKVFNRLSTLARH 320
Cdd:COG5048   390 LsnSCIRNFKRDSNLSLHIIthLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
300-661 1.11e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 1.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 300 KPYKCNECGKVFNRLSTLARHRRLHTGEKPYEC--EECEKVFSRKSHLERHKRIHTGEKPYKCkvCDKAFAYNSYLAKHS 377
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 378 IIHTGE---KPYKCNECGKVFNQQSTLARHHRLHTAEKPYKCEEC-----------DKVFRCKSHLER-----------H 432
Cdd:COG5048   110 LSSSSSnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnSLHPPLPANSLSkdpssnlslliS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 433 RRIHTGEKPYKCKVCDKAFRSDSCLTEHQRVHTGEKPYMCNECGKVFSTKA------NLACHHKLHTAEKPYKCEECEKV 506
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLlsqspsSLSSSDSSSSASESPRSSLPTAS 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 507 FSRKSHMERHRRIHTG-EKPYKCKVCDKAFRRDSHLAQHQR--VHTGE--KPYKCNE--CGKTFRQTSSLIIHRRLHTGE 579
Cdd:COG5048   270 SQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 580 KPYKCNECGKTFSQMSSL-------VYHHRLHSGEKPYKC--NECGKVFNQQAHLAQHQRVHTGEKP--YKCNECGKTFS 648
Cdd:COG5048   350 SPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFN 429

                         410
                  ....*....|...
gi 1620863302 649 QMSNLVYHHRLHS 661
Cdd:COG5048   430 RHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
214-602 2.14e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 2.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 214 DEKPYKCNECGKIFGHNTSLFLHKALHTADKPYEC--EECDKVFSRKSHLETHKIIYTGGKPYKCkvCDKAFTCNSYLAK 291
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASS 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 292 HTIIHTGE---KPYKCNECGKVFNRLSTLARHRRLHTGEKPYECEEC----------------------EKVFSRKSHLE 346
Cdd:COG5048   108 SSLSSSSSnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLL 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 347 RHKRIHTGEKPYKCKVCDKAFAYNSYLAKHSIIHTGEKPYKCNECGKVFNQQSTLARH------HRLHTAEKPYKCEECD 420
Cdd:COG5048   188 ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSSLPT 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 421 KVFRCKSHLERHRRIHTG-EKPYKCKVCDKAFRSDSCLTEHQR--VHTGE--KPYMCNE--CGKVFSTKANLACHHKLHT 493
Cdd:COG5048   268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 494 AEKPYKC--EECEKVFSRKSHMERH--RRIHTGEKPYKCKVCD-----KAFRRDSHLAQHQRVHTGEKP--YKCNECGKT 562
Cdd:COG5048   348 SISPAKEklLNSSSKFSPLLNNEPPqsLQQYKDLKNDKKSETLsnsciRNFKRDSNLSLHIITHLSFRPynCKNPPCSKS 427

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1620863302 563 FRQTSSLIIHRRLHTgEKPYKCNECGKTFSQMSSLVYHHR 602
Cdd:COG5048   428 FNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
384-662 5.40e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 5.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 384 KPYKCNECGKVFNQQSTLARHHRLHTAEKPYKC--EECDKVFRCKSHLERHRRIHTGEKPYKC--KVCDKAFRSDSCLTE 459
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNskSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 460 HQRVHTgEKPYMCNECGKVFSTKANLACHHKLHTAEKPYKCEEC----------------------EKVFSRKSHMERHR 517
Cdd:COG5048   112 SSSSNS-NDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 518 RIHTGEKPYKCKVCDKAFRRDSHLAQHQRVHTGEKPYKCNECGKTFRQTSSLIIHRRLHTGEKPYKCNECGKTFSQMSSL 597
Cdd:COG5048   191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1620863302 598 VYHHRLHSGE-------KPYKCNECGKVFNQQAHLAQHQR--VHTGE--KPYKCNE--CGKTFSQMSNLVYHHRLHSG 662
Cdd:COG5048   271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 522-605 2.17e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.41  E-value: 2.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 522 GEKPYKCKV--CDKAFRRDSHLAQHqRVHtgekpykcNECGKTFRQTSSLIIHRRLHTGEKPYKCNECGKTFSQMSSLVY 599
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1620863302 600 hHRLHS 605
Cdd:COG5189   417 -HRKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 573-661 2.70e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.02  E-value: 2.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 573 RRLHT-GEKPYKCN--ECGKTFSQMSSLVYHhRLHSgekpykcnECGKVFNQQAHLAQHQRVHTGEKPYKCNECGKTFSQ 649
Cdd:COG5189   340 RMLKVkDGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKN 410

                          90
                  ....*....|..
gi 1620863302 650 MSNLVYhHRLHS 661
Cdd:COG5189   411 LNGLKY-HRKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
410-663 5.27e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 5.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 410 AEKPYKCEECDKVFRCKSHLERHRRIHTGEKPYKCKV--CDKAFRSDSCLTEHQRVHTGEKPYMCNECGK---------- 477
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPlsnskassss 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 478 -----VFSTKANLACHHKLHTAEKP-------YKCEECEKVFSRKSHMERHRRIHTG---EKPYKCKVCDKAFRRDSHLa 542
Cdd:COG5048   110 lssssSNSNDNNLLSSHSLPPSSRDpqlpdllSISNLRNNPLPGNNSSSVNTPQSNSlhpPLPANSLSKDPSSNLSLLI- 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 543 qHQRVHTGEKPYKCNECGKTFRQTSSLIIHRRLHTGEKPYKCNECGKTFSQMSSLVYHHRLHSGEKPYKCNECGKVFNQQ 622
Cdd:COG5048   189 -SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1620863302 623 AHLAQHQRVHTGE-------KPYKCNECGKTFSQMSNLVYH--HRLHSGE 663
Cdd:COG5048   268 ASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGE 317
zf-H2C2_2 pfam13465
Zinc-finger double domain;
344-369 1.01e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.01e-04
                          10        20
                  ....*....|....*....|....*.
gi 1620863302 344 HLERHKRIHTGEKPYKCKVCDKAFAY 369
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 382-465 1.04e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 1.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 382 GEKPYKCN--ECGKVFNQQSTLaRHHRLHTAEKPYKCEECDKvfrckshlERHRRIHTGEKPYKCKVCDKAFRSDSCLTE 459
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGL-KYHMLHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1620863302 460 HqRVHT 465
Cdd:COG5189   417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
428-453 2.99e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.99e-04
                          10        20
                  ....*....|....*....|....*.
gi 1620863302 428 HLERHRRIHTGEKPYKCKVCDKAFRS 453
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
512-537 6.44e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.44e-04
                          10        20
                  ....*....|....*....|....*.
gi 1620863302 512 HMERHRRIHTGEKPYKCKVCDKAFRR 537
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 524-572 1.04e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.31  E-value: 1.04e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1620863302 524 KPYkCKVCDKAFRRDSHLAQHQRvhtgEKPYKCNECGKTFRQTSSLIIH 572
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVH 44
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 211-321 1.39e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 211 SHIDEKPYKCNECGKIFGHNTSLFLH---KALHTAD-KPYECE--ECDKVFSRKSHLETHKiiytggkpyKCKVCDKAFT 284
Cdd:COG5189   311 IDVRKLPCTNSSSNGKLAHGGERNIDtpsRMLKVKDgKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLH 381

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1620863302 285 CNSYLAKHTIIHTGEKPYKCNECGKVFNRLSTLARHR 321
Cdd:COG5189   382 ENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
624-649 1.64e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.64e-03
                          10        20
                  ....*....|....*....|....*.
gi 1620863302 624 HLAQHQRVHTGEKPYKCNECGKTFSQ 649
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 608-656 1.66e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.92  E-value: 1.66e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1620863302 608 KPYkCNECGKVFNQQAHLAQHQRvhtgEKPYKCNECGKTFSQMSNLVYH 656
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
540-565 2.22e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.22e-03
                          10        20
                  ....*....|....*....|....*.
gi 1620863302 540 HLAQHQRVHTGEKPYKCNECGKTFRQ 565
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
608-665 2.58e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 2.58e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 608 KPYKCNECGKVFNQQAHLAQHQRVHTGEKPYKCN--ECGKTFSQMSNLVYHHRLHSGEKP 665
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPS 91
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 321-409 3.93e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 3.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 321 RRLHT-GEKPYECE--ECEKVFSRKSHLERHkRIHTGEKPYKCKVCDKAfaynsylaKHSIIHTGEKPYKCNECGKVFNQ 397
Cdd:COG5189   340 RMLKVkDGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKN 410

                          90
                  ....*....|..
gi 1620863302 398 QSTLaRHHRLHT 409
Cdd:COG5189   411 LNGL-KYHRKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
96-320 6.39e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 6.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302  96 PELHIFQPEGKIGNQVEKSINNASSVSTSQRICCRPKTHiSNKYGNNSLHSSLLTQKRNVHMREKSFQCIESGKSFNCSS 175
Cdd:COG5048   231 TNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS-SQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHL 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1620863302 176 LLKKHQITHLEEKQCKCDVYGKVFNQKRYLACHRRSHIDEKPYKC--NECGKIFGH-----NTSLFLHKALHTADKPYEC 248
Cdd:COG5048   310 RSVNHSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPllnnePPQSLQQYKDLKNDKKSET 389

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1620863302 249 E--ECDKVFSRKSHLETHKI--IYTGGKPYKCKVCDKAFTCNSYLAKHTIIHTgEKPYKCNECGKVFNRLSTLARH 320
Cdd:COG5048   390 LsnSCIRNFKRDSNLSLHIIthLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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