NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1391723873|ref|NP_001350588|]
View 

bcl-2-associated transcription factor 1 isoform 5 [Homo sapiens]

Protein Classification

BCLAF1 and THRAP3 family protein( domain architecture ID 12173452)

BCLAF1 and THRAP3 family protein is an RNA processing factor that plays critical roles in maintaining DNA genomic stability, such as the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1) and thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
THRAP3_BCLAF1 pfam15440
THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 ...
 157-747 1.22e-105

THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay. It also includes the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1).


:

Pssm-ID: 464718  Cd Length: 641  Bit Score: 340.22  E-value: 1.22e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723873 157 KRRGSQEKQTKKAEGEPQEESPLKSKSQEEPKDTfehdpsesidefnKSSATSGDIWPGLSAYDNSPRSPHSPSPIATPP 236
Cdd:pfam15440  51 KRWRMDDKKHGQKDPRISPHGNDHNRSYEHRSPD-------------AKSSEASKSWSPKRRSPLESVYVYKPSPRPSPE 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723873 237 SQSSSCSDAPMLSTVHSAKNTPSQHSHSIQHSPersgsgsvgngsSRYSPSQNSPihhipSRRSPAKTIAPQNAPRDESR 316
Cdd:pfam15440 118 RGDSSRRDQYMPKPSEPSPYQYSPKQQGRYHGR------------GRGSPKGGSP-----PRRSPADSFSFEGKWHEDEL 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723873 317 GRSsFYPDGGDQETAKTGKFLKRFTDE-ESRVFLLDRGNTRDKEAsKEKGSEKGRAEG--EWEDQEALDYFSDKESGKQK 393
Cdd:pfam15440 181 RHQ-QSPRRGSEEFSARSSFQKRYPEEqDFRKYGHTSERGKEKEQ-KDARYEKREPARnsKWKDEHSLPPYQEKDDQRNK 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723873 394 F-NDSEGDDTEETEDYRQF--RKSVLADQGKSFATASHRNTE-EEGLKYKSKVSlKGNRESDGFREEKNYKLKEtgYVVE 469
Cdd:pfam15440 259 GpQSSRYAERESPESYDYRhkFEKKLAEFEKDFSDGRTEKYEkEDRKKFSSKIS-KGNRESDCFSEGRGRKTEE--GQVE 335

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723873 470 RPSTTKDKHKE--------EDKNSERITVKKETQSPEQVKSEKLKDLFDysppLHKNLDAREKSTFREESPlriKMIASD 541
Cdd:pfam15440 336 PSAKEKSKKDEiactdsmeNDVYLERFNDKKEEKSKKEGDFRKEAELSS----SSQHDDSREKPDVKESSP---KSVFSI 408

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723873 542 SHRPEVKLKMAPVPLDDSNRPASLTKDRLLASTLVHSVKKEQEFRSIFDHIKLPQASKSTSESFIQHIVSLVHHVKEQYF 621
Cdd:pfam15440 409 KRESTVKVDMDKFDEDLARPSSSLAQERQLSRDLVHSGKKDQEFRSIFEHIQSQQSERSPSEEFAQHIVTIVHHVKAHYF 488

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723873 622 KSAAMTLNERFTSYQK--ATEEHSTRQKSPEIHRRIDISPSTLRKHTRLAGEERVFKEENQKGDkKLRCDSADLRHDID- 698
Cdd:pfam15440 489 PSSGMTLHERFSKYQKraAEQEEMKSNKSPEIHRRIDMSPSALRKHRTLFEESKQSKESSYKEG-KVKEDPNDLRHDIEr 567

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1391723873 699 ------RRRKERSKERGDSKGSRESSGSRKQ-EKTPKDYKEYKSYKDDSKHKREQD 747
Cdd:pfam15440 568 rrkerlKERDEKRFHIRDSQDSRFSSLSRERtEKFQKPHKFSKKNFRTSKKRRDRI 623
 
Name Accession Description Interval E-value
THRAP3_BCLAF1 pfam15440
THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 ...
 157-747 1.22e-105

THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay. It also includes the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1).


Pssm-ID: 464718  Cd Length: 641  Bit Score: 340.22  E-value: 1.22e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723873 157 KRRGSQEKQTKKAEGEPQEESPLKSKSQEEPKDTfehdpsesidefnKSSATSGDIWPGLSAYDNSPRSPHSPSPIATPP 236
Cdd:pfam15440  51 KRWRMDDKKHGQKDPRISPHGNDHNRSYEHRSPD-------------AKSSEASKSWSPKRRSPLESVYVYKPSPRPSPE 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723873 237 SQSSSCSDAPMLSTVHSAKNTPSQHSHSIQHSPersgsgsvgngsSRYSPSQNSPihhipSRRSPAKTIAPQNAPRDESR 316
Cdd:pfam15440 118 RGDSSRRDQYMPKPSEPSPYQYSPKQQGRYHGR------------GRGSPKGGSP-----PRRSPADSFSFEGKWHEDEL 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723873 317 GRSsFYPDGGDQETAKTGKFLKRFTDE-ESRVFLLDRGNTRDKEAsKEKGSEKGRAEG--EWEDQEALDYFSDKESGKQK 393
Cdd:pfam15440 181 RHQ-QSPRRGSEEFSARSSFQKRYPEEqDFRKYGHTSERGKEKEQ-KDARYEKREPARnsKWKDEHSLPPYQEKDDQRNK 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723873 394 F-NDSEGDDTEETEDYRQF--RKSVLADQGKSFATASHRNTE-EEGLKYKSKVSlKGNRESDGFREEKNYKLKEtgYVVE 469
Cdd:pfam15440 259 GpQSSRYAERESPESYDYRhkFEKKLAEFEKDFSDGRTEKYEkEDRKKFSSKIS-KGNRESDCFSEGRGRKTEE--GQVE 335

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723873 470 RPSTTKDKHKE--------EDKNSERITVKKETQSPEQVKSEKLKDLFDysppLHKNLDAREKSTFREESPlriKMIASD 541
Cdd:pfam15440 336 PSAKEKSKKDEiactdsmeNDVYLERFNDKKEEKSKKEGDFRKEAELSS----SSQHDDSREKPDVKESSP---KSVFSI 408

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723873 542 SHRPEVKLKMAPVPLDDSNRPASLTKDRLLASTLVHSVKKEQEFRSIFDHIKLPQASKSTSESFIQHIVSLVHHVKEQYF 621
Cdd:pfam15440 409 KRESTVKVDMDKFDEDLARPSSSLAQERQLSRDLVHSGKKDQEFRSIFEHIQSQQSERSPSEEFAQHIVTIVHHVKAHYF 488

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723873 622 KSAAMTLNERFTSYQK--ATEEHSTRQKSPEIHRRIDISPSTLRKHTRLAGEERVFKEENQKGDkKLRCDSADLRHDID- 698
Cdd:pfam15440 489 PSSGMTLHERFSKYQKraAEQEEMKSNKSPEIHRRIDMSPSALRKHRTLFEESKQSKESSYKEG-KVKEDPNDLRHDIEr 567

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1391723873 699 ------RRRKERSKERGDSKGSRESSGSRKQ-EKTPKDYKEYKSYKDDSKHKREQD 747
Cdd:pfam15440 568 rrkerlKERDEKRFHIRDSQDSRFSSLSRERtEKFQKPHKFSKKNFRTSKKRRDRI 623
 
Name Accession Description Interval E-value
THRAP3_BCLAF1 pfam15440
THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 ...
 157-747 1.22e-105

THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay. It also includes the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1).


Pssm-ID: 464718  Cd Length: 641  Bit Score: 340.22  E-value: 1.22e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723873 157 KRRGSQEKQTKKAEGEPQEESPLKSKSQEEPKDTfehdpsesidefnKSSATSGDIWPGLSAYDNSPRSPHSPSPIATPP 236
Cdd:pfam15440  51 KRWRMDDKKHGQKDPRISPHGNDHNRSYEHRSPD-------------AKSSEASKSWSPKRRSPLESVYVYKPSPRPSPE 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723873 237 SQSSSCSDAPMLSTVHSAKNTPSQHSHSIQHSPersgsgsvgngsSRYSPSQNSPihhipSRRSPAKTIAPQNAPRDESR 316
Cdd:pfam15440 118 RGDSSRRDQYMPKPSEPSPYQYSPKQQGRYHGR------------GRGSPKGGSP-----PRRSPADSFSFEGKWHEDEL 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723873 317 GRSsFYPDGGDQETAKTGKFLKRFTDE-ESRVFLLDRGNTRDKEAsKEKGSEKGRAEG--EWEDQEALDYFSDKESGKQK 393
Cdd:pfam15440 181 RHQ-QSPRRGSEEFSARSSFQKRYPEEqDFRKYGHTSERGKEKEQ-KDARYEKREPARnsKWKDEHSLPPYQEKDDQRNK 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723873 394 F-NDSEGDDTEETEDYRQF--RKSVLADQGKSFATASHRNTE-EEGLKYKSKVSlKGNRESDGFREEKNYKLKEtgYVVE 469
Cdd:pfam15440 259 GpQSSRYAERESPESYDYRhkFEKKLAEFEKDFSDGRTEKYEkEDRKKFSSKIS-KGNRESDCFSEGRGRKTEE--GQVE 335

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723873 470 RPSTTKDKHKE--------EDKNSERITVKKETQSPEQVKSEKLKDLFDysppLHKNLDAREKSTFREESPlriKMIASD 541
Cdd:pfam15440 336 PSAKEKSKKDEiactdsmeNDVYLERFNDKKEEKSKKEGDFRKEAELSS----SSQHDDSREKPDVKESSP---KSVFSI 408

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723873 542 SHRPEVKLKMAPVPLDDSNRPASLTKDRLLASTLVHSVKKEQEFRSIFDHIKLPQASKSTSESFIQHIVSLVHHVKEQYF 621
Cdd:pfam15440 409 KRESTVKVDMDKFDEDLARPSSSLAQERQLSRDLVHSGKKDQEFRSIFEHIQSQQSERSPSEEFAQHIVTIVHHVKAHYF 488

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723873 622 KSAAMTLNERFTSYQK--ATEEHSTRQKSPEIHRRIDISPSTLRKHTRLAGEERVFKEENQKGDkKLRCDSADLRHDID- 698
Cdd:pfam15440 489 PSSGMTLHERFSKYQKraAEQEEMKSNKSPEIHRRIDMSPSALRKHRTLFEESKQSKESSYKEG-KVKEDPNDLRHDIEr 567

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1391723873 699 ------RRRKERSKERGDSKGSRESSGSRKQ-EKTPKDYKEYKSYKDDSKHKREQD 747
Cdd:pfam15440 568 rrkerlKERDEKRFHIRDSQDSRFSSLSRERtEKFQKPHKFSKKNFRTSKKRRDRI 623
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH