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Conserved domains on  [gi|1375022853|ref|NP_001348993|]
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EKC/KEOPS complex subunit Tprkb isoform a [Mus musculus]

Protein Classification

EKC/KEOPS complex subunit CGI121/TPRKB( domain architecture ID 10554361)

EKC/KEOPS complex subunit CGI121/TPRKB, such as CGI21 from fungi and its homolog, TPRKB (TP53RK-binding protein) from mammals, acts as an allosteric effector that regulates the t(6)A activity of the EKC/KEOPS complex, which is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CGI-121 pfam08617
Kinase binding protein CGI-121; CGI-121 has been shown to bind to the p53-related protein ...
 20-173 1.91e-62

Kinase binding protein CGI-121; CGI-121 has been shown to bind to the p53-related protein kinase (PRPK). PRPK is a novel protein kinase which binds to and induces phosphorylation of the tumour suppressor protein p53. CGI-121 is part of a conserved protein complex, KEOPS. The KEOPS complex is involved in telomere uncapping and telomere elongation. Interestingly this family also include archaeal homologs, formerly in the DUF509 family. A structure for these proteins has been solved by structural genomics.


:

Pssm-ID: 462537  Cd Length: 160  Bit Score: 189.67  E-value: 1.91e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375022853  20 FKDVKNAGDLRKKAMEGSIDG--SLINPNVIVDPFQILVAANKAVHLHRLGKMKTRTLSTEIIFNLSPNNNISEALKKFG 97
Cdd:pfam08617   1 FKNVTNAAELREQLLSGNAEFeyAFIDASLIVSRFHLLSAIYRALLAQKRGKLKTKNVHSEILFNLSPSNNISEALKRFG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375022853  98 ISETNTSVLIVYIEDGSKQVPQEHLVSQVEGQQVPL--ESLPEITRLSEVKKIYKLSSQE--ERIGTLLDAIICRMSTKD 173
Cdd:pfam08617  81 ISDDTSSLLVVKIGDSTNEDVLKHLLELVKGTEVPLsdENLSKLTDLAKIKKIYKLNGEEqeLERSELEDLVVGRIALKG 160
 
Name Accession Description Interval E-value
CGI-121 pfam08617
Kinase binding protein CGI-121; CGI-121 has been shown to bind to the p53-related protein ...
 20-173 1.91e-62

Kinase binding protein CGI-121; CGI-121 has been shown to bind to the p53-related protein kinase (PRPK). PRPK is a novel protein kinase which binds to and induces phosphorylation of the tumour suppressor protein p53. CGI-121 is part of a conserved protein complex, KEOPS. The KEOPS complex is involved in telomere uncapping and telomere elongation. Interestingly this family also include archaeal homologs, formerly in the DUF509 family. A structure for these proteins has been solved by structural genomics.


Pssm-ID: 462537  Cd Length: 160  Bit Score: 189.67  E-value: 1.91e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375022853  20 FKDVKNAGDLRKKAMEGSIDG--SLINPNVIVDPFQILVAANKAVHLHRLGKMKTRTLSTEIIFNLSPNNNISEALKKFG 97
Cdd:pfam08617   1 FKNVTNAAELREQLLSGNAEFeyAFIDASLIVSRFHLLSAIYRALLAQKRGKLKTKNVHSEILFNLSPSNNISEALKRFG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375022853  98 ISETNTSVLIVYIEDGSKQVPQEHLVSQVEGQQVPL--ESLPEITRLSEVKKIYKLSSQE--ERIGTLLDAIICRMSTKD 173
Cdd:pfam08617  81 ISDDTSSLLVVKIGDSTNEDVLKHLLELVKGTEVPLsdENLSKLTDLAKIKKIYKLNGEEqeLERSELEDLVVGRIALKG 160
PRK14886 PRK14886
KEOPS complex subunit Cgi121;
42-111 2.29e-04

KEOPS complex subunit Cgi121;


Pssm-ID: 237848  Cd Length: 167  Bit Score: 39.60  E-value: 2.29e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375022853  42 LINPNVIVDPFQILVAANKAVHLHRLGKMKTRTLSTEIIFNLSPNNNISEALKKFGISETNTSVLIVYIE 111
Cdd:PRK14886   35 AFNADCIAGREHVEHAIILALRAFERGRNIAKDLGVEILLRAAGRRQISRAIKIIGAKEGENNIVVVVDE 104
 
Name Accession Description Interval E-value
CGI-121 pfam08617
Kinase binding protein CGI-121; CGI-121 has been shown to bind to the p53-related protein ...
 20-173 1.91e-62

Kinase binding protein CGI-121; CGI-121 has been shown to bind to the p53-related protein kinase (PRPK). PRPK is a novel protein kinase which binds to and induces phosphorylation of the tumour suppressor protein p53. CGI-121 is part of a conserved protein complex, KEOPS. The KEOPS complex is involved in telomere uncapping and telomere elongation. Interestingly this family also include archaeal homologs, formerly in the DUF509 family. A structure for these proteins has been solved by structural genomics.


Pssm-ID: 462537  Cd Length: 160  Bit Score: 189.67  E-value: 1.91e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375022853  20 FKDVKNAGDLRKKAMEGSIDG--SLINPNVIVDPFQILVAANKAVHLHRLGKMKTRTLSTEIIFNLSPNNNISEALKKFG 97
Cdd:pfam08617   1 FKNVTNAAELREQLLSGNAEFeyAFIDASLIVSRFHLLSAIYRALLAQKRGKLKTKNVHSEILFNLSPSNNISEALKRFG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375022853  98 ISETNTSVLIVYIEDGSKQVPQEHLVSQVEGQQVPL--ESLPEITRLSEVKKIYKLSSQE--ERIGTLLDAIICRMSTKD 173
Cdd:pfam08617  81 ISDDTSSLLVVKIGDSTNEDVLKHLLELVKGTEVPLsdENLSKLTDLAKIKKIYKLNGEEqeLERSELEDLVVGRIALKG 160
PRK14886 PRK14886
KEOPS complex subunit Cgi121;
42-111 2.29e-04

KEOPS complex subunit Cgi121;


Pssm-ID: 237848  Cd Length: 167  Bit Score: 39.60  E-value: 2.29e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375022853  42 LINPNVIVDPFQILVAANKAVHLHRLGKMKTRTLSTEIIFNLSPNNNISEALKKFGISETNTSVLIVYIE 111
Cdd:PRK14886   35 AFNADCIAGREHVEHAIILALRAFERGRNIAKDLGVEILLRAAGRRQISRAIKIIGAKEGENNIVVVVDE 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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