NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1343071534|ref|NP_001347676|]
View 

olfactory receptor 701 [Mus musculus]

Protein Classification

olfactory receptor family 2 protein( domain architecture ID 11607568)

olfactory receptor family 2 protein is an odorant receptor belonging to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
26-300 5.56e-152

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


:

Pssm-ID: 320543  Cd Length: 277  Bit Score: 426.97  E-value: 5.56e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd15421     2 FLFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLL 185
Cdd:cd15421    82 TLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 186 KLACADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSF 265
Cdd:cd15421   162 KLSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSY 241
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1343071534 266 HSPKQDNIISVFYTIVTPALNPLIYSLRNKEVIGA 300
Cdd:cd15421   242 HSPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGA 276
 
Name Accession Description Interval E-value
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
26-300 5.56e-152

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 426.97  E-value: 5.56e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd15421     2 FLFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLL 185
Cdd:cd15421    82 TLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 186 KLACADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSF 265
Cdd:cd15421   162 KLSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSY 241
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1343071534 266 HSPKQDNIISVFYTIVTPALNPLIYSLRNKEVIGA 300
Cdd:cd15421   242 HSPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGA 276
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
34-305 1.36e-41

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 145.34  E-value: 1.36e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDL 113
Cdd:pfam13853   4 MYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 114 LLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADTS 193
Cdd:pfam13853  84 VLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIK 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 194 Q---YELMVYVTGVIFLLLplsAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFH--SP 268
Cdd:pfam13853 164 VnniYGLFVVTSTFGIDSL---LIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHnvPP 240
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1343071534 269 KQDNIISVFYTIVTPALNPLIYSLRNKEVIGAVRRVL 305
Cdd:pfam13853 241 LLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277
 
Name Accession Description Interval E-value
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
26-300 5.56e-152

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 426.97  E-value: 5.56e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd15421     2 FLFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLL 185
Cdd:cd15421    82 TLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 186 KLACADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSF 265
Cdd:cd15421   162 KLSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSY 241
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1343071534 266 HSPKQDNIISVFYTIVTPALNPLIYSLRNKEVIGA 300
Cdd:cd15421   242 HSPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGA 276
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
26-301 1.69e-125

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 359.85  E-value: 1.69e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd15225     2 LLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLL 185
Cdd:cd15225    82 FLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 186 KLACADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSF 265
Cdd:cd15225   162 KLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSS 241
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1343071534 266 HSPKQDNIISVFYTIVTPALNPLIYSLRNKEVIGAV 301
Cdd:cd15225   242 YSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
26-294 2.68e-115

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 333.68  E-value: 2.68e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd13954     2 LLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLL 185
Cdd:cd13954    82 SLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 186 KLACADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSF 265
Cdd:cd13954   162 KLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSS 241
                         250       260
                  ....*....|....*....|....*....
gi 1343071534 266 HSPKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd13954   242 YSSDLDKVVSVFYTVVTPMLNPIIYSLRN 270
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
26-294 7.51e-111

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 322.30  E-value: 7.51e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd15237     2 LLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLL 185
Cdd:cd15237    82 ALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 186 KLACADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSF 265
Cdd:cd15237   162 KLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHST 241
                         250       260
                  ....*....|....*....|....*....
gi 1343071534 266 HSPKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15237   242 HSPDQDKMISVFYTIVTPMLNPLIYSLRN 270
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
35-294 3.73e-110

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 320.61  E-value: 3.73e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  35 YMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDLL 114
Cdd:cd15230    11 YLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFGTTECFL 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 115 LAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADTSQ 194
Cdd:cd15230    91 LAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLLKLSCSDTHI 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 195 YELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHSPKQDNII 274
Cdd:cd15230   171 NELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSSYSLDQDKVV 250
                         250       260
                  ....*....|....*....|
gi 1343071534 275 SVFYTIVTPALNPLIYSLRN 294
Cdd:cd15230   251 SVFYTVVIPMLNPLIYSLRN 270
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
33-301 2.30e-105

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 308.81  E-value: 2.30e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  33 TLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAED 112
Cdd:cd15231     9 IIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVSFVGTEC 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 113 LLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADT 192
Cdd:cd15231    89 LLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLKLSCSDT 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 193 SQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHSPKQDN 272
Cdd:cd15231   169 SLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGYSLDKDT 248
                         250       260
                  ....*....|....*....|....*....
gi 1343071534 273 IISVFYTIVTPALNPLIYSLRNKEVIGAV 301
Cdd:cd15231   249 LISVLYSIVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
33-301 2.58e-102

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 301.06  E-value: 2.58e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  33 TLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAED 112
Cdd:cd15235    10 AMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIAFGNTDS 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 113 LLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADT 192
Cdd:cd15235    90 FLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLLKLSCSDT 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 193 SQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHSPKQDN 272
Cdd:cd15235   170 SLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPSSSYSADKDR 249
                         250       260
                  ....*....|....*....|....*....
gi 1343071534 273 IISVFYTIVTPALNPLIYSLRNKEVIGAV 301
Cdd:cd15235   250 VATVMYTVVTPMLNPFIYSLRNKDVKGAL 278
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
25-301 1.09e-101

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 299.68  E-value: 1.09e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  25 ELLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSA 104
Cdd:cd15434     1 KILSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 105 MTLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPL 184
Cdd:cd15434    81 LGLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPAL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 185 LKLACADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSS 264
Cdd:cd15434   161 IKLACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKN 240
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1343071534 265 FHSPKQDNIISVFYTIVTPALNPLIYSLRNKEVIGAV 301
Cdd:cd15434   241 SVSQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
12-305 3.32e-101

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 298.89  E-value: 3.32e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  12 FILVGILDGSGSPELLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNT 91
Cdd:cd15943     2 FILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKT 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  92 ISFEGCALQLFSAMTLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMS 171
Cdd:cd15943    82 ISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCGS 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 172 QEIRHLLCEVPPLLKLACADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMF 251
Cdd:cd15943   162 NVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTIF 241
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1343071534 252 YGGATFMYVLPSSFHSPKQDNIISVFYTIVTPALNPLIYSLRNKEVIGAVRRVL 305
Cdd:cd15943   242 YGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
26-300 3.36e-101

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 298.09  E-value: 3.36e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd15420     2 LLFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLL 185
Cdd:cd15420    82 ALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 186 KLACADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSF 265
Cdd:cd15420   162 KLACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSS 241
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1343071534 266 HSPKQDNIISVFYTIVTPALNPLIYSLRNKEVIGA 300
Cdd:cd15420   242 NSAEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGA 276
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
34-294 2.08e-100

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 295.90  E-value: 2.08e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDL 113
Cdd:cd15227    10 IYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFFAASELA 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 114 LLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADTS 193
Cdd:cd15227    90 LLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKLSCSDTY 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 194 QYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHSPKQDNI 273
Cdd:cd15227   170 LNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSPSLLDLL 249
                         250       260
                  ....*....|....*....|.
gi 1343071534 274 ISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15227   250 LSVFYSVVPPTLNPIIYSLRN 270
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
33-294 3.58e-100

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 295.29  E-value: 3.58e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  33 TLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAED 112
Cdd:cd15431     9 IVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFLGITEC 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 113 LLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHtVYTMHFPFCMSQEIRHLLCEVPPLLKLACADT 192
Cdd:cd15431    89 LLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIP-VLTMPLHFCGPNVINHFFCEVQALLKLACSDT 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 193 SQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHSPKQDN 272
Cdd:cd15431   168 SLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSKSSSDQDK 247
                         250       260
                  ....*....|....*....|..
gi 1343071534 273 IISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15431   248 IISVFYGVVTPMLNPLIYSLRN 269
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
12-297 6.96e-100

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 295.38  E-value: 6.96e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  12 FILVGILDGSGSPELLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNT 91
Cdd:cd15408     1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  92 ISFEGCALQLFSAMTLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMS 171
Cdd:cd15408    81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 172 QEIRHLLCEVPPLLKLACADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMF 251
Cdd:cd15408   161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLF 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1343071534 252 YGGATFMYVLPSSFHSPKQDNIISVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15408   241 YGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEV 286
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
33-294 2.74e-99

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 292.98  E-value: 2.74e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  33 TLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAED 112
Cdd:cd15918     9 GMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFGDLDN 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 113 LLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADT 192
Cdd:cd15918    89 FLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLKLSCSDT 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 193 SQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHSPKQDN 272
Cdd:cd15918   169 HLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSHSASKDS 248
                         250       260
                  ....*....|....*....|..
gi 1343071534 273 IISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15918   249 VAAVMYTVVTPMLNPFIYSLRN 270
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
33-303 4.71e-99

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 292.68  E-value: 4.71e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  33 TLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAED 112
Cdd:cd15419     9 VIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLFGTTEG 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 113 LLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADT 192
Cdd:cd15419    89 FLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLLKLSCSDT 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 193 SQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHSPKQDN 272
Cdd:cd15419   169 FINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGAVSSPEQSK 248
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1343071534 273 IISVFYTIVTPALNPLIYSLRNKEVIGAVRR 303
Cdd:cd15419   249 VVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
27-294 4.25e-98

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 289.91  E-value: 4.25e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  27 LCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMT 106
Cdd:cd15947     3 LFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLW 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 107 LGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLK 186
Cdd:cd15947    83 LGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIK 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 187 LACADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFH 266
Cdd:cd15947   163 LACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSSY 242
                         250       260
                  ....*....|....*....|....*...
gi 1343071534 267 SPKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15947   243 SQDQGKFISLFYTVVTPTLNPLIYTLRN 270
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
26-294 1.41e-97

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 288.61  E-value: 1.41e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd15912     2 LLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLL 185
Cdd:cd15912    82 FLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 186 KLACADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSF 265
Cdd:cd15912   162 KLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQS 241
                         250       260
                  ....*....|....*....|....*....
gi 1343071534 266 HSPKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15912   242 SSLDLNKVVALLNTVVTPLLNPFIYTLRN 270
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
35-301 3.09e-96

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 285.64  E-value: 3.09e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  35 YMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDLL 114
Cdd:cd15229    11 YLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFAGTEAFL 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 115 LAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADTSQ 194
Cdd:cd15229    91 LSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLPLSCSDTFA 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 195 YELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHSPKQDNII 274
Cdd:cd15229   171 NKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSASSSVLDRVF 250
                         250       260
                  ....*....|....*....|....*..
gi 1343071534 275 SVFYTIVTPALNPLIYSLRNKEVIGAV 301
Cdd:cd15229   251 SIQYSILTPMLNPIIYSLKNKEVKAAL 277
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
12-305 6.44e-96

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 285.32  E-value: 6.44e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  12 FILVGILDGSGSPELLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNT 91
Cdd:cd15410     1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  92 ISFEGCALQLFSAMTLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMS 171
Cdd:cd15410    81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 172 QEIRHLLCEVPPLLKLACADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMF 251
Cdd:cd15410   161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIF 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1343071534 252 YGGATFMYVLPSSFHSPKQDNIISVFYTIVTPALNPLIYSLRNKEVIGAVRRVL 305
Cdd:cd15410   241 HGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
33-300 4.53e-94

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 280.06  E-value: 4.53e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  33 TLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAED 112
Cdd:cd15429     9 VMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLALGGTEF 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 113 LLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADT 192
Cdd:cd15429    89 ILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVRLACVDT 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 193 SQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHSPKQDN 272
Cdd:cd15429   169 SLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGSSALQEK 248
                         250       260
                  ....*....|....*....|....*...
gi 1343071534 273 IISVFYTIVTPALNPLIYSLRNKEVIGA 300
Cdd:cd15429   249 MISLFYAVVTPMLNPLIYSLRNKEVKGA 276
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
34-303 1.61e-93

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 278.82  E-value: 1.61e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDL 113
Cdd:cd15411    10 IYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIALATTECF 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 114 LLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADTS 193
Cdd:cd15411    90 LLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLKLSCSDTH 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 194 QYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHSPKQDNI 273
Cdd:cd15411   170 VNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSSYSLGQDKV 249
                         250       260       270
                  ....*....|....*....|....*....|
gi 1343071534 274 ISVFYTIVTPALNPLIYSLRNKEVIGAVRR 303
Cdd:cd15411   250 ASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
34-305 1.63e-93

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 279.25  E-value: 1.63e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDL 113
Cdd:cd15406    19 IYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYPECMTQLFFFCVFAIAECY 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 114 LLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADTS 193
Cdd:cd15406    99 MLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVINHYFCDILPLLKLSCSSTY 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 194 QYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHSPKQDNI 273
Cdd:cd15406   179 INELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSIIFMYLKPSSSSSMTQEKV 258
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1343071534 274 ISVFYTIVTPALNPLIYSLRNKEVIGAVRRVL 305
Cdd:cd15406   259 SSVFYTTVIPMLNPLIYSLRNKDVKNALKKVL 290
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
34-303 4.47e-93

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 277.60  E-value: 4.47e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDL 113
Cdd:cd15417    10 IYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGMGLTECF 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 114 LLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADTS 193
Cdd:cd15417    90 LLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLLSLSCSDTF 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 194 QYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHSPKQDNI 273
Cdd:cd15417   170 ISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSSHSQDQDKV 249
                         250       260       270
                  ....*....|....*....|....*....|
gi 1343071534 274 ISVFYTIVTPALNPLIYSLRNKEVIGAVRR 303
Cdd:cd15417   250 ASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
34-303 4.62e-93

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 277.71  E-value: 4.62e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDL 113
Cdd:cd15416    10 IYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATFGTVECF 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 114 LLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADTS 193
Cdd:cd15416    90 LLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLKLSCSDIR 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 194 QYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHSPKQDNI 273
Cdd:cd15416   170 LAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSYSMDQNKV 249
                         250       260       270
                  ....*....|....*....|....*....|
gi 1343071534 274 ISVFYTIVTPALNPLIYSLRNKEVIGAVRR 303
Cdd:cd15416   250 VSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
34-294 9.21e-92

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 274.14  E-value: 9.21e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDL 113
Cdd:cd15232    10 LYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWSLGSELL 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 114 LLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADTS 193
Cdd:cd15232    90 LLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLLLLSCSDTS 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 194 QYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHSPKQDNI 273
Cdd:cd15232   170 LNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSSYSPEKDKV 249
                         250       260
                  ....*....|....*....|.
gi 1343071534 274 ISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15232   250 VAVLYSVVTPTLNPLIYSLRN 270
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
34-294 1.47e-91

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 273.48  E-value: 1.47e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDL 113
Cdd:cd15430    10 MYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAMGSTECV 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 114 LLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADTS 193
Cdd:cd15430    90 LLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVLKLACVDIS 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 194 QYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHSPKQDNI 273
Cdd:cd15430   170 LNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSKNAQISDKL 249
                         250       260
                  ....*....|....*....|.
gi 1343071534 274 ISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15430   250 ITLFYGVVTPMLNPIIYSLRN 270
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
12-303 1.86e-91

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 273.93  E-value: 1.86e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  12 FILVGILDGSGSPELLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNT 91
Cdd:cd15945     1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  92 ISFEGCALQLFSAMTLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMS 171
Cdd:cd15945    81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 172 QEIRHLLCEVPPLLKLACADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMF 251
Cdd:cd15945   161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1343071534 252 YGGATFMYVLPSSFHSPKQDNIISVFYTIVTPALNPLIYSLRNKEVIGAVRR 303
Cdd:cd15945   241 YGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
35-294 1.95e-91

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 273.21  E-value: 1.95e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  35 YMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDLL 114
Cdd:cd15911    11 YIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSLAATECYL 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 115 LAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADTSQ 194
Cdd:cd15911    91 LAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLKLSCSDTSL 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 195 YELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHSPKQDNII 274
Cdd:cd15911   171 VELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTNTSRDLNKVF 250
                         250       260
                  ....*....|....*....|
gi 1343071534 275 SVFYTIVTPALNPLIYSLRN 294
Cdd:cd15911   251 SLFYTVLTPLVNPLIYSLRN 270
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
34-303 3.50e-90

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 270.35  E-value: 3.50e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDL 113
Cdd:cd15413    10 IYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTFIISELF 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 114 LLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADTS 193
Cdd:cd15413    90 LLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLALSCSDTH 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 194 QYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHSPKQDNI 273
Cdd:cd15413   170 EKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSSHSLDTDKM 249
                         250       260       270
                  ....*....|....*....|....*....|
gi 1343071534 274 ISVFYTIVTPALNPLIYSLRNKEVIGAVRR 303
Cdd:cd15413   250 ASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
34-303 1.92e-89

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 268.51  E-value: 1.92e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDL 113
Cdd:cd15409    10 IYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSATTECF 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 114 LLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADTS 193
Cdd:cd15409    90 LLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLLKISCTDPS 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 194 QYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHSPKQDNI 273
Cdd:cd15409   170 INELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSLYALDQDMM 249
                         250       260       270
                  ....*....|....*....|....*....|
gi 1343071534 274 ISVFYTIVTPALNPLIYSLRNKEVIGAVRR 303
Cdd:cd15409   250 DSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
33-301 7.31e-89

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 266.75  E-value: 7.31e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  33 TLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAED 112
Cdd:cd15234     9 SMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLFGGLDN 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 113 LLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADT 192
Cdd:cd15234    89 FLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLKLACSDT 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 193 SQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHSPKQDN 272
Cdd:cd15234   169 LINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVTHSSRKTA 248
                         250       260
                  ....*....|....*....|....*....
gi 1343071534 273 IISVFYTIVTPALNPLIYSLRNKEVIGAV 301
Cdd:cd15234   249 VASVMYTVVTPMLNPFIYSLRNKDMKGAL 277
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
26-301 3.42e-88

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 265.06  E-value: 3.42e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd15424     2 LLFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIAL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLL 185
Cdd:cd15424    82 SLGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 186 KLACADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSF 265
Cdd:cd15424   162 KLACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSG 241
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1343071534 266 HSPKQDNIISVFYTIVTPALNPLIYSLRNKEVIGAV 301
Cdd:cd15424   242 STPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
26-294 1.70e-87

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 262.99  E-value: 1.70e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd15224     2 LLFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLL 185
Cdd:cd15224    82 SLACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 186 KLACADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSF 265
Cdd:cd15224   162 NLSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAI 241
                         250       260
                  ....*....|....*....|....*....
gi 1343071534 266 HSPKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15224   242 SSFDSNKLVSVLYTVVTPLLNPIIYCLRN 270
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
12-305 8.99e-87

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 262.03  E-value: 8.99e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  12 FILVGILDGSGSPELLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNT 91
Cdd:cd15944     1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  92 ISFEGCALQLFSAMTLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMS 171
Cdd:cd15944    81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 172 QEIRHLLCEVPPLLKLACADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMF 251
Cdd:cd15944   161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1343071534 252 YGGATFMYVLPSSFHSPKQDNIISVFYTIVTPALNPLIYSLRNKEVIGAVRRVL 305
Cdd:cd15944   241 YGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
30-303 2.56e-85

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 257.73  E-value: 2.56e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  30 TVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGG 109
Cdd:cd15407     6 IFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVFAT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 110 AEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLAC 189
Cdd:cd15407    86 VENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLALSC 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 190 ADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHSPK 269
Cdd:cd15407   166 SDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSHSMD 245
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1343071534 270 QDNIISVFYTIVTPALNPLIYSLRNKEVIGAVRR 303
Cdd:cd15407   246 TDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
34-294 8.44e-85

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 256.46  E-value: 8.44e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDL 113
Cdd:cd15915    10 LYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFLGSSEAM 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 114 LLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADTS 193
Cdd:cd15915    90 LLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLKLACGDTS 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 194 QYE-LMVYVTGVIfLLLPLSAIITSYSLILFTVLHMP-SNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHSPKQD 271
Cdd:cd15915   170 LNLwLLNIVTGSI-ALGTFILTLLSYIYIISFLLLKVrSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSGDSLEQD 248
                         250       260
                  ....*....|....*....|...
gi 1343071534 272 NIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15915   249 RIVALLYTVVTPVLNPLIYTLRN 271
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
26-294 2.69e-84

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 254.82  E-value: 2.69e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd15226     2 FLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLH 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLL 185
Cdd:cd15226    82 FFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVI 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 186 KLACADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSnEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSF 265
Cdd:cd15226   162 KLACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRKHSS-GGSSKALSTCSAHITVVVLFFGPCIFIYVWPFST 240
                         250       260
                  ....*....|....*....|....*....
gi 1343071534 266 HSpkQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15226   241 FP--VDKFLAVFYTVITPLLNPIIYTLRN 267
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
34-303 3.11e-84

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 255.03  E-value: 3.11e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDL 113
Cdd:cd15415    10 IYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFVTTEGF 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 114 LLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADTS 193
Cdd:cd15415    90 LLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKLSCSDTH 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 194 QYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHSPKQDNI 273
Cdd:cd15415   170 INELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQYSLEQEKV 249
                         250       260       270
                  ....*....|....*....|....*....|
gi 1343071534 274 ISVFYTIVTPALNPLIYSLRNKEVIGAVRR 303
Cdd:cd15415   250 SAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
34-294 7.27e-84

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 253.67  E-value: 7.27e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDL 113
Cdd:cd15939    10 IYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFFGGAEIF 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 114 LLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADTS 193
Cdd:cd15939    90 LLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLKLACTDTY 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 194 QYELMVYVTGVIFLLLPLSAIITSYSLILFTvLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHSpkQDNI 273
Cdd:cd15939   170 VIGLLVVANSGLICLLSFLILLISYIVILYS-LRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTFP--IDKV 246
                         250       260
                  ....*....|....*....|.
gi 1343071534 274 ISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15939   247 VAVFYTIITPMLNPLIYTLRN 267
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
26-294 1.09e-83

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 253.55  E-value: 1.09e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd15946     2 ILFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLL 185
Cdd:cd15946    82 ALGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 186 KLACADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSF 265
Cdd:cd15946   162 KLACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSN 241
                         250       260
                  ....*....|....*....|....*....
gi 1343071534 266 HSPKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15946   242 YSPERDKKISLFYNVFTALLNPVIYSLRN 270
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
35-307 3.54e-83

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 252.73  E-value: 3.54e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  35 YMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDLL 114
Cdd:cd15414    11 YLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLFVAAECFL 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 115 LAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADTSQ 194
Cdd:cd15414    91 LASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLLSLSCADTQI 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 195 YELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHSPKQDNII 274
Cdd:cd15414   171 NKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSSSSLDLDKVV 250
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1343071534 275 SVFYTIVTPALNPLIYSLRNKEVIGAVRRVLGR 307
Cdd:cd15414   251 SVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRR 283
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
26-301 3.43e-82

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 249.70  E-value: 3.43e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd15428     2 LLFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLL 185
Cdd:cd15428    82 SFGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 186 KLACADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSF 265
Cdd:cd15428   162 KLASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSS 241
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1343071534 266 HSPKQDNIISVFYTIVTPALNPLIYSLRNKEVIGAV 301
Cdd:cd15428   242 TSKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
26-303 1.01e-81

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 248.85  E-value: 1.01e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd15412     2 LLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLL 185
Cdd:cd15412    82 ALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLI 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 186 KLACADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSF 265
Cdd:cd15412   162 KLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSE 241
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1343071534 266 HSPKQDNIISVFYTIVTPALNPLIYSLRNKEVIGAVRR 303
Cdd:cd15412   242 ESVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
35-301 4.14e-81

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 247.01  E-value: 4.14e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  35 YMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDLL 114
Cdd:cd15432    11 YILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLGLGSTECVL 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 115 LAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADTSQ 194
Cdd:cd15432    91 LAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLKLSCVDTTA 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 195 YELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHSPKQDNII 274
Cdd:cd15432   171 NEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSNSSHDRGKMV 250
                         250       260
                  ....*....|....*....|....*..
gi 1343071534 275 SVFYTIVTPALNPLIYSLRNKEVIGAV 301
Cdd:cd15432   251 ALFYGIITPMLNPLIYTLRNKDVKEAL 277
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
34-304 5.92e-80

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 244.31  E-value: 5.92e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDL 113
Cdd:cd15418    11 SYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSAGLAYSECF 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 114 LLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADTS 193
Cdd:cd15418    91 LLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLVKLACDDTR 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 194 QYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHSPKQDNI 273
Cdd:cd15418   171 VYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPSSSHTPDRDKV 250
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1343071534 274 ISVFYTIVTPALNPLIYSLRNKEVIGAVRRV 304
Cdd:cd15418   251 VALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
35-297 9.34e-80

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 243.48  E-value: 9.34e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  35 YMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDLL 114
Cdd:cd15405    11 YVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFFVISECYV 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 115 LAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADTSQ 194
Cdd:cd15405    91 LTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQLSCTSTYV 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 195 YELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHSPKQDNII 274
Cdd:cd15405   171 NELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVGSVNQGKVS 250
                         250       260
                  ....*....|....*....|...
gi 1343071534 275 SVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15405   251 SVFYTNVVPMLNPLIYSLRNKDV 273
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
26-294 4.21e-77

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 236.44  E-value: 4.21e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd15913     2 LLFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLL 185
Cdd:cd15913    82 SLGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 186 KLACADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSF 265
Cdd:cd15913   162 ALSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSG 241
                         250       260
                  ....*....|....*....|....*....
gi 1343071534 266 HSPKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15913   242 NSTGMQKIVTLFYSVVTPLLNPLIYSLRN 270
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
25-301 1.23e-75

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 233.15  E-value: 1.23e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  25 ELLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSA 104
Cdd:cd15433     1 PVLFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 105 MTLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPL 184
Cdd:cd15433    81 LALGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 185 LKLACADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSS 264
Cdd:cd15433   161 LKLACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIH 240
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1343071534 265 FHSPKQDNIISVFYTIVTPALNPLIYSLRNKEVIGAV 301
Cdd:cd15433   241 RYSQAHGKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
26-300 5.43e-74

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 228.86  E-value: 5.43e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd15228     2 ILFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYH 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLL 185
Cdd:cd15228    82 FLGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 186 KLACADTSQYELMVYV-TGVIFLLLPLSaIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSS 264
Cdd:cd15228   162 KLACADTSIAETVSFTnVGLVPLTCFLL-ILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTP 240
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1343071534 265 fhSPKQDNIISVFYTIVTPALNPLIYSLRNKEVIGA 300
Cdd:cd15228   241 --SPVLVTPVQIFNNVVTPMLNPLIYTLRNKEVKAA 274
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
34-301 1.15e-73

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 228.11  E-value: 1.15e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDL 113
Cdd:cd15236    10 MYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFFGCLDSF 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 114 LLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADTS 193
Cdd:cd15236    90 LLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKLSCSSTS 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 194 QYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHSPKQDNI 273
Cdd:cd15236   170 LNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNSSDKDIV 249
                         250       260
                  ....*....|....*....|....*...
gi 1343071534 274 ISVFYTIVTPALNPLIYSLRNKEVIGAV 301
Cdd:cd15236   250 ASVMYTVVTPMLNPFIYSLRNRDIKGAL 277
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
34-297 5.06e-73

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 226.56  E-value: 5.06e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRD-NTISFEGCALQLFSAMTLGGAED 112
Cdd:cd15916    10 IYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGgKVISFGGCVAQLYFFHFLGSTEC 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 113 LLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADT 192
Cdd:cd15916    90 FLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLLKLACADT 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 193 SQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSfhSPKQDN 272
Cdd:cd15916   170 TINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGS--KEALDG 247
                         250       260
                  ....*....|....*....|....*
gi 1343071534 273 IISVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15916   248 VIAVFYTVVTPLLNPLIYTLRNKEV 272
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
34-294 1.19e-72

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 225.01  E-value: 1.19e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDL 113
Cdd:cd15940    10 LYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFACTEIF 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 114 LLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADTS 193
Cdd:cd15940    90 LLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIKLACTDTY 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 194 QYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMpSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSfhSPKQDNI 273
Cdd:cd15940   170 LIDILIVSNSGLISLVCFVALLGSYIVILVSLRKR-STEGRRKALSTCASHLTVVTLFFGPCIFIYTRPST--SFSEDKV 246
                         250       260
                  ....*....|....*....|.
gi 1343071534 274 ISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15940   247 VSVFYTVVTPLLNPIIYTLRN 267
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
26-300 5.98e-71

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 221.20  E-value: 5.98e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd15233     2 VLFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFH 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLL 185
Cdd:cd15233    82 LLAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLF 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 186 KLACADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSF 265
Cdd:cd15233   162 QLSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSV 241
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1343071534 266 HSPKQDNIISVFYTIVTPALNPLIYSLRNKEVIGA 300
Cdd:cd15233   242 YSSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGA 276
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
34-301 1.11e-70

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 220.38  E-value: 1.11e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDL 113
Cdd:cd15942    10 VYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFLGCAECF 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 114 LLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADTS 193
Cdd:cd15942    90 LYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLKLACADTA 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 194 QYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHSpkQDNI 273
Cdd:cd15942   170 FNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQDP--LDGV 247
                         250       260
                  ....*....|....*....|....*...
gi 1343071534 274 ISVFYTIVTPALNPLIYSLRNKEVIGAV 301
Cdd:cd15942   248 VAVFYTTVTPLLNPVIYTLRNKEMKDAL 275
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
34-294 2.11e-70

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 219.55  E-value: 2.11e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDL 113
Cdd:cd15914    10 IYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHSLGITECY 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 114 LLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADTS 193
Cdd:cd15914    90 LLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLSLACTDTS 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 194 QYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHSPKQDNI 273
Cdd:cd15914   170 LNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKSYSLDYDRA 249
                         250       260
                  ....*....|....*....|.
gi 1343071534 274 ISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15914   250 IAVVYAVLTPFFNPIIYSLRN 270
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
33-294 8.04e-68

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 212.96  E-value: 8.04e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  33 TLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAED 112
Cdd:cd15936     9 LVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTGGAEV 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 113 LLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADT 192
Cdd:cd15936    89 FLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIKLACTDT 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 193 SQYE-LMVY----VTGVIFLLLplsaiITSYSLILFTvLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPssFHS 267
Cdd:cd15936   169 FLLElLMVSnsglVTLLIFFIL-----LISYTVILVK-IRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARP--FQT 240
                         250       260
                  ....*....|....*....|....*..
gi 1343071534 268 PKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15936   241 FPMDKAVSVLYTVITPMLNPMIYTLRN 267
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
32-301 1.57e-65

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 207.39  E-value: 1.57e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  32 TTLYMLALISNGLLLLVITVDARLH-VPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRD-NTISFEGCALQLFSAMTLGG 109
Cdd:cd15941     8 LLIYLLTVLGNLLILLTIGSDPHLHgLPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSgRTISFEGCVVQLYAFHFLAS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 110 AEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLAC 189
Cdd:cd15941    88 TECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPVLKLAC 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 190 ADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSfhSPK 269
Cdd:cd15941   168 ADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSS--SQA 245
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1343071534 270 QDNIISVFYTIVTPALNPLIYSLRNKEVIGAV 301
Cdd:cd15941   246 GAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
35-294 2.27e-63

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 201.25  E-value: 2.27e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  35 YMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDLL 114
Cdd:cd15938    11 YTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFVGAAEMFL 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 115 LAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADTSQ 194
Cdd:cd15938    91 LTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIKLACTDTCV 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 195 YELMVYVTGVIFLLLPLSAIITSYSLILFTVlhmPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPssFHSPKQDNII 274
Cdd:cd15938   171 TELLMVSNSGLISTVCFVVLVTSYTTILVTI---RSTEGRRKALSTCASHLMVVTLFFGPCIFIYARP--FSTFPVDKHV 245
                         250       260
                  ....*....|....*....|
gi 1343071534 275 SVFYTIVTPALNPLIYSLRN 294
Cdd:cd15938   246 SVLYNVITPMLNPLIYTLRN 265
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
26-294 3.65e-62

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 198.45  E-value: 3.65e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARL-HVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSA 104
Cdd:cd15935     2 LLFVLVLACYAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 105 MTLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPL 184
Cdd:cd15935    82 HFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQV 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 185 LKLACADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTvLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPss 264
Cdd:cd15935   162 IKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTT-LRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRP-- 238
                         250       260       270
                  ....*....|....*....|....*....|
gi 1343071534 265 FHSPKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15935   239 FSSSSVDKVASVFYTLITPALNPLIYTLRN 268
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
26-294 8.30e-58

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 187.25  E-value: 8.30e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd15937     2 LLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLH 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLL 185
Cdd:cd15937    82 FLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVI 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 186 KLACADTSQYELMVYVTGVIFLLLPLSAIITSYSLILfTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPssF 265
Cdd:cd15937   162 KLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLL-AKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARP--F 238
                         250       260
                  ....*....|....*....|....*....
gi 1343071534 266 HSPKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15937   239 RSFPMDKVVAVFHTVIFPLLNPMIYTLRN 267
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
32-297 1.13e-54

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 179.41  E-value: 1.13e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  32 TTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAE 111
Cdd:cd15223     8 LLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHFFTAME 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 112 DLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACAD 191
Cdd:cd15223    88 SSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVSLACGD 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 192 TSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYV-------LPSS 264
Cdd:cd15223   168 TTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLtyrfgktIPPD 247
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1343071534 265 FHspkqdNIISVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15223   248 VH-----VLLSVLYILIPPALNPIIYGVRTKEI 275
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
34-297 2.79e-54

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 178.25  E-value: 2.79e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDL 113
Cdd:cd15917    10 MYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAMESG 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 114 LLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADTS 193
Cdd:cd15917    90 VLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLACGDTR 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 194 Q---YELMVYVTGVIFLLLplsAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPS-SFHSPK 269
Cdd:cd15917   170 VnsiYGLFVALLIVGFDLL---FIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRfGHHVPP 246
                         250       260
                  ....*....|....*....|....*....
gi 1343071534 270 QDNII-SVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15917   247 HVHILlANLYLLLPPMLNPIVYGVRTKQI 275
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
33-297 2.44e-50

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 167.98  E-value: 2.44e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  33 TLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAED 112
Cdd:cd15950     9 SMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAVES 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 113 LLLAFMAYDRYVAICHPLNYMIFMSP------------KACRLMVAISWILASLsalghtvytmhfPFCMSQEIRHLLCE 180
Cdd:cd15950    89 GVLLAMAFDRYVAICHPLRYSAILTSqviaqiglaivlRALLFMTPLTCLVTSL------------PYCGSRVVPHSYCE 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 181 VPPLLKLACADT---SQYELMV--YVTGVIFLLlplsaIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFY-GG 254
Cdd:cd15950   157 HMAVVKLACADPrpsSLYSITGstLVVGTDSAF-----IAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYiPG 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1343071534 255 ATFMYVLPSSFHSPKQDNI-ISVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15950   232 LLSIYTQRFGQGVPPHTQVlLADLYLLVPPMLNPIIYGMRTKQI 275
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
34-297 4.30e-49

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 164.77  E-value: 4.30e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDL 113
Cdd:cd15221    10 MYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVTESA 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 114 LLAFMAYDRYVAICHPLNYMIFMSPKACRlMVAISWILASLSALGHTVYTM-HFPFCMSQEIRHLLCEVPPLLKLACADT 192
Cdd:cd15221    90 ILLAMAFDRYVAICYPLRYTTILTHSVIG-KIGVAAVARSFCIVFPFVFLLkRLPYCGHNVIPHTYCEHMGIARLACADI 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 193 S---QYELMVYVTGVIfllLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYV-------LP 262
Cdd:cd15221   169 TvniWYGLTVALLTVG---LDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLthrfgrhIP 245
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1343071534 263 SSFHSpkqdnIISVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15221   246 RHVHI-----LLANLYVLVPPMLNPIVYGVKTKQI 275
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
33-297 4.88e-47

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 159.47  E-value: 4.88e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  33 TLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAED 112
Cdd:cd15952     9 AVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGMES 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 113 LLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADT 192
Cdd:cd15952    89 AVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACASI 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 193 SQYelMVYVTGVI-FLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYV-------LPSS 264
Cdd:cd15952   169 RIN--IIYGLFAIsVLVLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLthrfghnIPRY 246
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1343071534 265 FHSpkqdnIISVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15952   247 IHI-----LLANLYVVLPPMLNPVIYGVRTKQI 274
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
31-297 2.40e-46

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 157.81  E-value: 2.40e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  31 VTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGA 110
Cdd:cd15953     7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIM 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 111 EDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACA 190
Cdd:cd15953    87 ESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLACG 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 191 DTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHS--P 268
Cdd:cd15953   167 DTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLTHRFGQGiaP 246
                         250       260
                  ....*....|....*....|....*....
gi 1343071534 269 KQDNIISVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15953   247 HIHIILANLYLLVPPMLNPIIYGVKTKEI 275
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
33-297 5.16e-45

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 154.43  E-value: 5.16e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  33 TLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAED 112
Cdd:cd15951     9 IMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTMES 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 113 LLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADT 192
Cdd:cd15951    89 GIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACADT 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 193 ---SQYELMV--YVTGVIFLLlplsaIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHS 267
Cdd:cd15951   169 rvsRAYGLSVafLVGGLDVIF-----IAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLTHRFGHN 243
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1343071534 268 -PKQDNI-ISVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15951   244 vPPHVHIlIANVYLLVPPMLNPIIYGVRTKQI 275
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
34-297 9.22e-43

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 148.42  E-value: 9.22e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDL 113
Cdd:cd15222    10 LYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFSFMESS 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 114 LLAFMAYDRYVAICHPLNYM-IFMSPKACRLMVAISwILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADT 192
Cdd:cd15222    90 VLLAMAFDRFVAICNPLRYAsILTNSRIAKIGLAIV-LRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMKLACSDT 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 193 ---SQYELMV--YVTGVIFLLlplsaIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYG---GATFMYvLPSS 264
Cdd:cd15222   169 rvnSIYGLFVvlSTMGLDSLL-----ILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVpmiGLSMVH-RFGK 242
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1343071534 265 FHSPKQDNIISVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15222   243 HASPLVHVLMANVYLLVPPVLNPIIYSVKTKQI 275
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
34-305 1.36e-41

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 145.34  E-value: 1.36e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDL 113
Cdd:pfam13853   4 MYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 114 LLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADTS 193
Cdd:pfam13853  84 VLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIK 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 194 Q---YELMVYVTGVIFLLLplsAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFH--SP 268
Cdd:pfam13853 164 VnniYGLFVVTSTFGIDSL---LIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHnvPP 240
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1343071534 269 KQDNIISVFYTIVTPALNPLIYSLRNKEVIGAVRRVL 305
Cdd:pfam13853 241 LLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
34-297 2.03e-39

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 139.61  E-value: 2.03e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDL 113
Cdd:cd15956    10 IYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAMESG 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 114 LLAFMAYDRYVAICHPLNYMIFMSpKACrlmVAISWILASLSALGHTVY----TMHFPFCMSQEIRHLLCEVPPLLKLAC 189
Cdd:cd15956    90 VLVAMALDRFVAICNPLHYATILT-LEV---VAKAGLLLALRGVAIVIPfpllVCRLSFCASHTIAHTYCEHMAVVKLAC 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 190 ADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFHS-- 267
Cdd:cd15956   166 GATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRFGHSvp 245
                         250       260       270
                  ....*....|....*....|....*....|
gi 1343071534 268 PKQDNIISVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15956   246 SAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
33-297 1.58e-38

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 137.34  E-value: 1.58e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  33 TLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAED 112
Cdd:cd15948    10 SAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIMES 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 113 LLLAFMAYDRYVAICHPLNYMIFMSPKacrLMVAIswilaSLSALGHTVYTM--------HFPFCMSQEIRHLLCEVPPL 184
Cdd:cd15948    90 AVLLAMAFDRYVAICNPLRYATILTNS---VITKI-----GLAALARAVTLMtplpfllrRLPYCRSHVIAHCYCEHMAV 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 185 LKLACADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGAtfmyVLPSS 264
Cdd:cd15948   162 VKLACGDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPV----VLSST 237
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1343071534 265 FH------SPKQDNIISVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15948   238 MHrfarhvAPHVHILLANFYLLFPPMMNPIVYGVKTKQI 276
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
33-297 2.00e-34

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 126.42  E-value: 2.00e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  33 TLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAED 112
Cdd:cd15955     9 IMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAFES 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 113 LLLAFMAYDRYVAICHPLNYMIFMSPK---ACRLMVAISWILASLSALGHTVYTMHfpFCMSQEIRHLLCEVPPLLKLAC 189
Cdd:cd15955    89 GILLAMALDRYVAICHPLRHSSILTPQvllGIGVLVVVRAVVLIIPCPLLIKLRLH--HFRSTVISHSYCEHMAVVKLAA 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 190 ADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYVLPSSFH--S 267
Cdd:cd15955   167 DDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHRFGHhvA 246
                         250       260       270
                  ....*....|....*....|....*....|
gi 1343071534 268 PKQDNIISVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15955   247 PYVHILLSNLYLLVPPVLNPIVYGVKTKQI 276
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
42-290 4.62e-34

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 125.10  E-value: 4.62e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  42 NGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLL-RDNTISFEGCALQLFSAMTLGGAEDLLLAFMAY 120
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAISI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 121 DRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHfpfCMSQEIRHLLCEVPPLLKLACadtsqYELMVY 200
Cdd:pfam00001  82 DRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWT---LTVPEGNVTVCFIDFPEDLSK-----PVSYTL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 201 VTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGR-------KKALVTCSSHLTVVGMFYGGATFMYVLPSSFHSPKQDNI 273
Cdd:pfam00001 154 LISVLGFLLPLLVILVCYTLIIRTLRKSASKQKSsertqrrRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRL 233
                         250       260
                  ....*....|....*....|...
gi 1343071534 274 ISVFYTI------VTPALNPLIY 290
Cdd:pfam00001 234 LDKALSVtlwlayVNSCLNPIIY 256
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
10-297 4.92e-32

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 120.65  E-value: 4.92e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  10 SGFILVGILDGSGSPELLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRD 89
Cdd:cd15949     2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  90 NTISFEGCALQLFSAMTLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFC 169
Cdd:cd15949    82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 170 MSQEIRHLLCEVPPLLKLACADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVG 249
Cdd:cd15949   162 RTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAIL 241
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1343071534 250 MFYggatFMYVLPSSFH------SPKQDNIISVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15949   242 AFY----VPIAVSSLIHrfgqnvPPPTHILLANFYLLIPPMLNPIVYGVRTKQI 291
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
34-297 4.38e-31

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 117.62  E-value: 4.38e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDL 113
Cdd:cd15954    10 MYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGMESG 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 114 LLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPPLLKLACADTS 193
Cdd:cd15954    90 VLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACANIR 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 194 QYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMFYGGATFMYV---LPSSFHSPKQ 270
Cdd:cd15954   170 VDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFahrFGGHHITPHI 249
                         250       260
                  ....*....|....*....|....*..
gi 1343071534 271 DNIISVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15954   250 HIIMANLYLLLPPMMNPIVYGVKTKQI 276
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
37-294 3.62e-23

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 96.59  E-value: 3.62e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  37 LALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDLLLA 116
Cdd:cd00637    11 VGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSLLASILTLT 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 117 FMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFcmsqeirhllceVPPLLKLACADTSQYE 196
Cdd:cd00637    91 AISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDY------------GGYCCCCLCWPDLTLS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 197 LMVYVTG-VIFLLLPLSAIITSYSLILFTVLH--------------MPSNEGRKKALVTCsshLTVVGMF------YGGA 255
Cdd:cd00637   159 KAYTIFLfVLLFLLPLLVIIVCYVRIFRKLRRhrrrirssssnssrRRRRRRERKVTKTL---LIVVVVFllcwlpYFIL 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1343071534 256 TFMYVL-PSSFHSPKQDNIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd00637   236 LLLDVFgPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
26-296 7.04e-18

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 81.46  E-value: 7.04e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd14967     1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSAlghtvytmhFPFCMsqeIRHLLCEVPPLL 185
Cdd:cd14967    81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLIS---------LPPLV---GWRDETQPSVVD 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 186 KLACADTSQYELMVYVTGVIFllLPLSAIITSYSLILFTVLHmpsnegRKKALVTCSshlTVVGMFYGG---ATFMYVLp 262
Cdd:cd14967   149 CECEFTPNKIYVLVSSVISFF--IPLLIMIVLYARIFRVARR------ELKAAKTLA---IIVGAFLLCwlpFFIIYLV- 216
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1343071534 263 SSFHSPkqDNIISVFYTIVT------PALNPLIYSLRNKE 296
Cdd:cd14967   217 SAFCPP--DCVPPILYAVFFwlgylnSALNPIIYALFNRD 254
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
25-296 3.57e-13

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 68.39  E-value: 3.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  25 ELLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSA 104
Cdd:cd14969     1 YVLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 105 MTLGGAEDLLLAFMAYDRYVAICHPLNYmIFMSPKACRLMVAISWILAslsalghtvytmhfpfcmsqeirhLLCEVPPL 184
Cdd:cd14969    81 TFLGLVSISTLAALAFERYLVIVRPLKA-FRLSKRRALILIAFIWLYG------------------------LFWALPPL 135
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 185 L----------KLACA-----DTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHL---- 245
Cdd:cd14969   136 FgwssyvpeggGTSCSvdwysKDPNSLSYIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNSAITKRTKkaek 215
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1343071534 246 ----TVVGMFyggATFM-----YVLPSSFHSPKQDNIISVfYTIVTPAL--------NPLIYSLRNKE 296
Cdd:cd14969   216 kvakMVLVMI---VAFLiawtpYAVVSLYVSFGGESTIPP-LLATIPALfaksstiyNPIIYVFMNKQ 279
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
37-295 1.10e-11

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 64.16  E-value: 1.10e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  37 LALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDLLLA 116
Cdd:cd14993    13 LALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQGVSVSASVLTLV 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 117 FMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALghtvytmhfPFCMSQEIRHL-LCEVPPLLKLACAD--TS 193
Cdd:cd14993    93 AISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIML---------PLLVVYELEEIiSSEPGTITIYICTEdwPS 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 194 QYELMVYVTG--VIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSH------------LTVVGMF-------Y 252
Cdd:cd14993   164 PELRKAYNVAlfVVLYVLPLLIISVAYSLIGRRLWRRKPPGDRGSANSTSSRRilrskkkvarmlIVVVVLFalswlpyY 243
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1343071534 253 ggATFMYVLPSSFHSPKQDNIISVFYTIVT------PALNPLIYSLRNK 295
Cdd:cd14993   244 --VLSILLDFGPLSSEESDENFLLILPFAQllgysnSAINPIIYCFMSK 290
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
29-157 3.96e-11

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 62.25  E-value: 3.96e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  29 ATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLL--FTSVVTPntvvdfLLRDNTISFEG----CALQLF 102
Cdd:cd15196     5 AVLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLvaLFNVLPQ------LIWDITYRFYGgdllCRLVKY 78
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1343071534 103 SAMTLGGAEDLLLAFMAYDRYVAICHPLNYMIFmSPKACRLMVAISWILASLSAL 157
Cdd:cd15196    79 LQVVGMYASSYVLVATAIDRYIAICHPLSSHRW-TSRRVHLMVAIAWVLSLLLSI 132
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
26-221 6.59e-10

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 58.89  E-value: 6.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd15389     2 LLIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMifMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEvpPLL 185
Cdd:cd15389    82 CSVYVSTLTLTAIALDRHRVILHPLKPR--ITPCQGVVVIAIIWIMASCLSLPHAIYQKLVEFEYSNERTRSRCL--PSF 157
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1343071534 186 KLACADTSQYelMVYVTGVIFLLLPLSAIITSYSLI 221
Cdd:cd15389   158 PEPSDLFWKY--LDLATFILQYVLPLLIIGVAYTRV 191
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
38-301 9.62e-10

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 58.46  E-value: 9.62e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  38 ALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLfTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDLLLAF 117
Cdd:cd14972    12 IVVENSLVLAAIIKNRRLHKPMYILIANLAAADLL-AGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSLLASAYSLLA 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 118 MAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALghtvytmhfPFCMSQEIRHLLCEvppllklACADTSQYEL 197
Cdd:cd14972    91 IAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLAL---------LPVLGWNCVLCDQE-------SCSPLGPGLP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 198 MVY-VTGVIFLLLPLSAIITSYSLIlFTVLHMPSNEGRKKALVTCSSHL--------TVV---GMF-YGGATFMYVLPSS 264
Cdd:cd14972   155 KSYlVLILVFFFIALVIIVFLYVRI-FWCLWRHANAIAARQEAAVPAQPstsrklakTVVivlGVFlVCWLPLLILLVLD 233
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1343071534 265 FHSPKQDNIISVFYTIVTPAL-----NPLIYSLRNKEVIGAV 301
Cdd:cd14972   234 VLCPSVCDIQAVFYYFLVLALlnsaiNPIIYAFRLKEMRRAV 275
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
29-225 5.55e-09

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 56.23  E-value: 5.55e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  29 ATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDlLFTSVVTPNT------VVDFLLRDNtisfeGCALQLF 102
Cdd:cd14986     5 AVLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIAD-LVVAFFTVLTqiiweaTGEWVAGDV-----LCRIVKY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 103 SAMTLGGAEDLLLAFMAYDRYVAICHPLNYMifMSPKACRLMVAISWILASLSA-----------LGHTVYTmhfpfCMS 171
Cdd:cd14986    79 LQVVGLFASTYILVSMSLDRYQAIVKPMSSL--KPRKRARLMIVVAWVLSFLFSipqlvifvereLGDGVHQ-----CWS 151
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1343071534 172 QEIrhllcevppllklacadtSQYELMVYVTGVIFLLL--PLSAIITSYSLILFTV 225
Cdd:cd14986   152 SFY------------------TPWQRKVYITWLATYVFviPLIILSYCYGRILRTI 189
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
26-292 1.62e-08

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 55.05  E-value: 1.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFL-LRDNTISFEGCALQLFSA 104
Cdd:cd14979     2 LVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWwQYPWAFGDGGCKLYYFLF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 105 MTLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSAlghtvytMHFPFCMSQEIRHLLCEVPPL 184
Cdd:cd14979    82 EACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCA-------IPILFLMGIQYLNGPLPGPVP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 185 LKLAC---ADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSN--EGRKKALVTC------SSHLTVVGMFYG 253
Cdd:cd14979   155 DSAVCtlvVDRSTFKYVFQVSTFIFFVLPMFVISILYFRIGVKLRSMRNIkkGTRAQGTRNVelslsqQARRQVVKMLGA 234
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1343071534 254 GATFMYVLPSSFH--------SPKQDNIISVFYTIVTP----------ALNPLIYSL 292
Cdd:cd14979   235 VVIAFFVCWLPFHaqrlmfsyASKEDTFLFDFYQYLYPisgilfylssAINPILYNL 291
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
26-157 3.25e-08

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 53.49  E-value: 3.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd15064     2 LISVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLDV 81
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSAL 157
Cdd:cd15064    82 TCCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISL 133
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
31-228 1.58e-07

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 52.01  E-value: 1.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  31 VTTLYMLALIS---NGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTP-----NTVVDFLLRDNTisfegCALQLF 102
Cdd:cd15195     4 VLVTWVLFVISaagNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPmdavwNYTVEWLAGDLM-----CRVMMF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 103 SAMTLGGAEDLLLAFMAYDRYVAICHPLNymIFMSPKACRLMVAISWILASLSALGhtvytmhfPFCMSQEIRHLlCEVP 182
Cdd:cd15195    79 LKQFGMYLSSFMLVVIALDRVFAILSPLS--ANQARKRVKIMLTVAWVLSALCSIP--------QSFIFSVLRKM-PEQP 147
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1343071534 183 PLLKlaCADT------SQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHM 228
Cdd:cd15195   148 GFHQ--CVDFgsaptkKQERLYYFFTMILSFVIPLIITVTCYLLILFEISKM 197
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
31-226 1.85e-07

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 51.67  E-value: 1.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  31 VTTLYMLALI----SNGLLLLVITVDARlHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLlrDNTISFEGCALQLFSAMT 106
Cdd:cd15372     3 VPSLYTLVFLvglpANGLALWVLATQVK-RLPSTIFLINLAVADLLLILVLPFKISYHFL--GNNWPFGEGLCRVVTAFF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 107 LGG--AEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFcmsQEIRHLLC-EVPP 183
Cdd:cd15372    80 YGNmyCSVLLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLPLTLQRQSYPL---ERLNITLChDVLP 156
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1343071534 184 LlklaCADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTVL 226
Cdd:cd15372   157 L----DEQDTYLFYYFACLAVLGFLLPLVVILFCYGSVLHTLL 195
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
37-296 2.66e-07

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 51.10  E-value: 2.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  37 LALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVdfLLRDNTISFEGCALQLFSAMTLGGAEDLLLA 116
Cdd:cd14968    13 LSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAIL--ISLGLPTNFHGCLFMACLVLVLTQSSIFSLL 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 117 FMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALghtvytmhFPFcMSQEIRHLLCEVPPLLKLACADTS--Q 194
Cdd:cd14968    91 AIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGL--------TPM-FGWNNGAPLESGCGEGGIQCLFEEviP 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 195 YELMVYVTGVIFLLLPLSAIITSYSLILFTVlhmpSNEGRKKALVTCSSH--------------LTVVGMFYGGA----- 255
Cdd:cd14968   162 MDYMVYFNFFACVLVPLLIMLVIYLRIFRVI----RKQLRQIESLLRSRRsrstlqkevkaaksLAIILFLFALCwlplh 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1343071534 256 ---TFMYVLPSSfHSPKQDNIISVFYTIVTPALNPLIYSLRNKE 296
Cdd:cd14968   238 iinCITLFCPEC-KVPKILTYIAILLSHANSAVNPIVYAYRIRK 280
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
37-296 2.99e-07

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 50.73  E-value: 2.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  37 LALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVtPNTVVDFLLRDNTISFE----GCALQLFSAMTLGGaed 112
Cdd:cd14982    13 LGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTL-PFRIYYYLNGGWWPFGDflcrLTGLLFYINMYGSI--- 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 113 LLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALghtvytmhfPFCMSQEIRHLLCEVPPLLKLACADT 192
Cdd:cd14982    89 LFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASV---------PLLLLRSTIAKENNSTTCFEFLSEWL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 193 SQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEG----RKKALVTCSSHLTV-VGMF--YGGATFMYVL--PS 263
Cdd:cd14982   160 ASAAPIVLIALVVGFLIPLLIILVCYSLIIRALRRRSKQSQksvrKRKALRMILIVLAVfLVCFlpYHVTRILYLLvrLS 239
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1343071534 264 SFHSPKQDNIISVFYTI------VTPALNPLIYSLRNKE 296
Cdd:cd14982   240 FIADCSARNSLYKAYRItlclasLNSCLDPLIYYFLSKT 278
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
97-158 4.37e-07

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 50.25  E-value: 4.37e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1343071534  97 CALQLFSAMTLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALG 158
Cdd:cd15055    73 CKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSV 134
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
30-223 5.49e-07

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 49.99  E-value: 5.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  30 TVTTLYM----LALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVtPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd14970     2 VIPAVYSvvcvVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGL-PFLATSYLLGYWPFGEVMCKIVLSVDA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFcmSQEIRHLLCEVPpll 185
Cdd:cd14970    81 YNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTLQE--EGGTISCNLQWP--- 155
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1343071534 186 klacaDTSQYELMVYVTGVIFL--LLPLSAIITSYSLILF 223
Cdd:cd14970   156 -----DPPDYWGRVFTIYTFVLgfAVPLLVITVCYSLIIR 190
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
26-152 6.34e-07

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 49.92  E-value: 6.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd15335     2 LIVLTLALITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSVDM 81
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILA 152
Cdd:cd15335    82 TCCTCSILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTIS 128
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
34-295 7.03e-07

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 49.70  E-value: 7.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGC-ALQLFSAMTLGGAED 112
Cdd:cd15206    10 IFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCkLIPYFQAVSVSVSTF 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 113 LLLAfMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPfcMSQEIRHLLCEVPPLlklacadt 192
Cdd:cd15206    90 TLVA-ISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIP--MSRPGGHKCREVWPN-------- 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 193 SQYELMVYVTGVIFLL-LPLSAIITSYSLILFTVLhmpsnEGRKKALVTCsshLTVVGMFYGGATFMYVLP--SSFHSPK 269
Cdd:cd15206   159 EIAEQAWYVFLDLMLLvIPGLVMSVAYGLISWTLL-----EAKKRVIRML---FVIVVEFFICWTPLYVINtwKAFDPPS 230
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1343071534 270 QDN-----IISVFYTI--VTPALNPLIYSLRNK 295
Cdd:cd15206   231 AARyvsstTISLIQLLayISSCVNPITYCFMNK 263
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
29-167 7.34e-07

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 49.94  E-value: 7.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  29 ATVTTLYMLALISNGLLLLVITVDARLHV--PMYLLLRQLSLIDLLFTSVVTPntvVDFLLRDNTISFEG----CALQLF 102
Cdd:cd14981     5 APPALMFVFGVLGNLLALIVLARSSKSHKwsVFYRLVAGLAITDLLGILLTSP---VVLAVYASNFEWDGgqplCDYFGF 81
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1343071534 103 SAMTLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWI----LASLSALGHTVYTMHFP 167
Cdd:cd14981    82 MMSFFGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAfallIASLPLLGLGSYVLQYP 150
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
26-294 9.85e-07

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 49.43  E-value: 9.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd15202     2 LLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIfmSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLC-EVPPl 184
Cdd:cd15202    82 CSVHVSAYTLTAIAVDRYQAIMHPLKPRI--SKTKAKFIIAVIWTLALAFALPHAICSKLETFKYSEDIVRSLClEDWP- 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 185 lklACADTSQYELMVYVTGVIFlLLPLSAIITSYSLILFTVL--HMPSN-EGRKKALVTCSSHLTVVGMFYGGATF---- 257
Cdd:cd15202   159 ---ERADLFWKYYDLALFILQY-FLPLLVISFAYARVGIKLWasNMPGDaTTERYFALRRKKKKVIKMLMVVVVLFalcw 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1343071534 258 -----MYVLPSSFHSPKQDNIISVFYTIVTPAL-----NPLIYSLRN 294
Cdd:cd15202   235 lpfniYVLLLSSKPDYLIKTINAVYFAFHWLAMsstcyNPFIYCWLN 281
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
46-165 1.00e-06

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 49.16  E-value: 1.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  46 LLVITVDA---RLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLlrdNTISFEG---CALQLFSAMTLGGAEDLLLAFMA 119
Cdd:cd15314    19 LLVIISIAhfkQLHTPTNYLILSLAVADLLVGGLVMPPSMVRSV---ETCWYFGdlfCKIHSSFDITLCTASILNLCFIS 95
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1343071534 120 YDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMH 165
Cdd:cd15314    96 IDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALVGFGIIFLELN 141
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
26-236 1.05e-06

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 49.36  E-value: 1.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd15012     1 IFIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWIlasLSALGHTVYtmhfpFCMSQEIRHLLCEVPPLL 185
Cdd:cd15012    81 LSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWL---TSAVYNTPY-----FVFSQTVEILVTQDGQEE 152
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1343071534 186 KLACADTSQYELMVY--VTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKK 236
Cdd:cd15012   153 EICVLDREMFNSKLYdtINFIVWYLIPLLIMTVLYSKISIVLWKSSSIEARRK 205
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
31-225 1.39e-06

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 49.17  E-value: 1.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  31 VTTLYMLALISNGLLLLVITVDaRLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQL-----FSAM 105
Cdd:cd14978     7 LPVICIFGIIGNILNLVVLTRK-SMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYFlpyiyPLAN 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGH--TVYTMHFPFCMSQEIRHLLCEVPP 183
Cdd:cd14978    86 TFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRffEYEVVECENCNNNSYYYVIPTLLR 165
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1343071534 184 LlklacADTSQYELMVYVTGVIFLLLPLSAIITSYSLILFTV 225
Cdd:cd14978   166 Q-----NETYLLKYYFWLYAIFVVLLPFILLLILNILLIRAL 202
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
26-157 1.71e-06

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 48.41  E-value: 1.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVdFLLRDNTISFEG-CALQLFSA 104
Cdd:cd15334     2 LISLTLSILALMTTAINSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIM-YIVKETWIMGQVvCDIWLSVD 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1343071534 105 MTLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSAL 157
Cdd:cd15334    81 ITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISM 133
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
37-158 1.80e-06

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 48.50  E-value: 1.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  37 LALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDfllrdntiSFEGC------ALQLFSA--MTLG 108
Cdd:cd15312    13 LTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVR--------SVESCwyfgdlFCKIHSSldMMLS 84
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1343071534 109 GAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALG 158
Cdd:cd15312    85 TTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFAFG 134
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
29-152 2.26e-06

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 48.28  E-value: 2.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  29 ATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLlftsVVTPNTVVDFLLRDNTISFEG----CA----LQ 100
Cdd:cd15385     5 AVLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADL----VVAFFQVLPQLCWDITYRFYGpdflCRivkhLQ 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1343071534 101 LFSAMtlggAEDLLLAFMAYDRYVAICHPLNyMIFMSPKACRLMVAISWILA 152
Cdd:cd15385    81 VLGMF----ASTYMLVMMTADRYIAICHPLK-TLQQPTKRSYLMIGSAWALS 127
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
26-154 2.57e-06

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 48.04  E-value: 2.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd15329     2 LIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFDV 81
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASL 154
Cdd:cd15329    82 LLCTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSAL 130
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
29-154 4.54e-06

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 47.42  E-value: 4.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  29 ATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLlFTSVVtpNTVVDFLLRdNTISFE----GCALQLFSA 104
Cdd:cd15197     5 ATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADL-CVGLI--NVLTDIIWR-ITVEWRagdfACKVIRYLQ 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1343071534 105 MTLGGAEDLLLAFMAYDRYVAICHPLNYMifMSPKACRLMVAISWILASL 154
Cdd:cd15197    81 VVVTYASTYVLVALSIDRYDAICHPMNFS--QSGRQARVLICVAWILSAL 128
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
29-152 6.23e-06

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 46.71  E-value: 6.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  29 ATVTTLYMLA-LISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTL 107
Cdd:cd15333     8 AVLLALITLAtTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIWLSSDITC 87
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1343071534 108 GGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILA 152
Cdd:cd15333    88 CTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVIS 132
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
37-237 1.07e-05

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 46.13  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  37 LALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDLLLA 116
Cdd:cd15096    13 VGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTAYASVYTLV 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 117 FMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALghTVYTMHfpfcMSQEIRHLLCEVPpllklACADTSQYE 196
Cdd:cd15096    93 LMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILVANI--PVLFLH----GVVSYGFSSEAYS-----YCTFLTEVG 161
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1343071534 197 LMVYVTGVIFL----LLPLSAIITSYSLILFTVLHMPSNEGRKKA 237
Cdd:cd15096   162 TAAQTFFTSFFlfsyLIPLTLICVLYMLMLRRLRRQKSPGGRRSA 206
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
37-238 1.07e-05

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 46.05  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  37 LALISNGLLLLVITVDARLHVP--MYLLlrQLSLIDLLFtsVVT-PNTVVDFLLRDNTISFEgCalQLFSAMTLGG--AE 111
Cdd:cd14984    13 LGLVGNSLVLLVLLYYRKLRSMtdVYLL--NLALADLLF--VLTlPFWAVYAADGWVFGSFL-C--KLVSALYTINfySG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 112 DLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMhfpfcMSQEIRHLLCEV--PPLLKLAC 189
Cdd:cd14984    86 ILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIFSQ-----VSEENGSSICSYdyPEDTATTW 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1343071534 190 ADTSQYELMvyvtgVIFLLLPLSAIITSYSLILFTVLHMPsNEGRKKAL 238
Cdd:cd14984   161 KTLLRLLQN-----ILGFLLPLLVMLFCYSRIIRTLLRAR-NHKKHRAL 203
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
29-157 1.40e-05

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 45.91  E-value: 1.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  29 ATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPnTVVDFLLRDNTISFE--GCALQLFSAMT 106
Cdd:cd15005     5 TTLGLILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFP-FVMASVRHGSGWIYGalSCKVIAFLAVL 83
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1343071534 107 LGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSAL 157
Cdd:cd15005    84 FCFHSAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAF 134
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
29-157 2.32e-05

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 45.17  E-value: 2.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  29 ATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLlftsVVTPNTVVDFLLRDNTISFEG----C-ALQLFS 103
Cdd:cd15386     5 GVLAAILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDL----VVALFQVLPQLIWEITYRFQGpdllCrAVKYLQ 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1343071534 104 AMTLGGAEDLLLAfMAYDRYVAICHPLNYMIFMSPKACrLMVAISWILASLSAL 157
Cdd:cd15386    81 VLSMFASTYMLIM-MTVDRYIAVCHPLRTLQQPSRQAY-LMIGATWLLSCILSL 132
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
26-225 2.67e-05

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 45.02  E-value: 2.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd15083     2 VLGIFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASL----SALGHTVYTMHfpfcmsqeirHLLCEV 181
Cdd:cd15083    82 LFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLwvlpPLFGWSRYVLE----------GLLTSC 151
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1343071534 182 PpLLKLACADTSQYELMVYVTGVIFLllPLSAIITSYSLILFTV 225
Cdd:cd15083   152 S-FDYLSRDDANRSYVICLLIFGFVL--PLLIIIYCYSFIFRAV 192
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
33-154 3.20e-05

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 44.73  E-value: 3.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  33 TLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAED 112
Cdd:cd15050     9 TISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTASI 88
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1343071534 113 LLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASL 154
Cdd:cd15050    89 FSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFL 130
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
29-152 3.45e-05

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 44.41  E-value: 3.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  29 ATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLG 108
Cdd:cd15063     5 LVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWMC 84
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1343071534 109 GAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILA 152
Cdd:cd15063    85 TASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLS 128
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
36-158 3.65e-05

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 44.62  E-value: 3.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  36 MLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTpntvvdFLLRdnTIS---------FEGCALQLFSAMT 106
Cdd:cd15337    12 ILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVNG------FPLK--TISsfnkkwiwgKVACELYGFAGGI 83
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1343071534 107 LGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALG 158
Cdd:cd15337    84 FGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIP 135
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
26-152 4.01e-05

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 44.39  E-value: 4.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd15205     2 AFVITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPFVQS 81
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILA 152
Cdd:cd15205    82 TAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVS 128
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
121-221 4.16e-05

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 44.63  E-value: 4.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 121 DRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALghtvytmhfPFCMSQEIRHLlcEVPPLLK------LACADTSQ 194
Cdd:cd15134    98 ERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCAL---------PFAIQTRIVYL--EYPPTSGealeesAFCAMLNE 166
                          90       100       110
                  ....*....|....*....|....*....|
gi 1343071534 195 YELMVYVTGV---IFLLLPLSAIITSYSLI 221
Cdd:cd15134   167 IPPITPVFQLstfLFFIIPMIAIIVLYVLI 196
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
26-154 5.23e-05

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 43.88  E-value: 5.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVdFLLRDNTISFEGCALQLFSAM 105
Cdd:cd15067     1 LLGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSIL-HEMTGGYWLFGRDWCDVWHSF 79
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1343071534 106 TLGG--AEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASL 154
Cdd:cd15067    80 DVLAstASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSAL 130
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
33-167 5.46e-05

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 44.02  E-value: 5.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  33 TLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQ----LFSAMTLG 108
Cdd:cd15103     9 TLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQhidnVIDSMICS 88
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1343071534 109 G--AEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFP 167
Cdd:cd15103    89 SllASICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGILFIIYSDSVP 149
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
34-227 6.10e-05

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 44.10  E-value: 6.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVvTPNTVVDFLLRDNTISFEGCalQLFSAM-TLGG-AE 111
Cdd:cd15079    10 LGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIK-MPIFIYNSFYEGWALGPLGC--QIYAFLgSLSGiGS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 112 DLLLAFMAYDRYVAICHPLNyMIFMSPKACRLMVAISWILAslsalghtvytmhFPFCmsqeirhllceVPPLLKL---- 187
Cdd:cd15079    87 IWTNAAIAYDRYNVIVKPLN-GNPLTRGKALLLILFIWLYA-------------LPWA-----------LLPLLFGwgry 141
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1343071534 188 -------ACA-D--TSQYELMVYVtGVIFL---LLPLSAIITSYSLILFTVLH 227
Cdd:cd15079   142 vpegfltSCSfDylTRDWNTRSFV-ATIFVfayVIPLIIIIYCYSFIVKAVFA 193
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
29-164 7.29e-05

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 43.83  E-value: 7.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  29 ATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVtPNTVVDFLLRDNTISFEGCALQLFSAMTLG 108
Cdd:cd15090     5 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTL-PFQSVNYLMGTWPFGNILCKIVISIDYYNM 83
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1343071534 109 GAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILAslSALGHTVYTM 164
Cdd:cd15090    84 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILS--SAIGLPVMFM 137
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
26-153 8.31e-05

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 43.40  E-value: 8.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVtPNTVVDFLLrdNTISFEGCALQLFSAM 105
Cdd:cd15091     2 IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTM-PFQSTVYLM--NSWPFGDVLCKIVISI 78
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1343071534 106 TLGG--AEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILAS 153
Cdd:cd15091    79 DYYNmfTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSS 128
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
32-221 8.36e-05

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 43.44  E-value: 8.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  32 TTLYMLALISNGLLLLVITVDARLH-VPMYLLLrQLSLIDLLFTSVVTPNTVVdFLLRDNTISFE-GCALQLFSAMTLGG 109
Cdd:cd15390     8 VVMVLVAIGGNLIVIWIVLAHKRMRtVTNYFLV-NLAVADLLISAFNTVFNFT-YLLYNDWPFGLfYCKFSNFVAITTVA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 110 AEDLLLAFMAYDRYVAICHPLNYMifMSPKACRLMVAISWILASLSALGHTVY--TMHFPFCMSQEIRHLLCEVPPllkl 187
Cdd:cd15390    86 ASVFTLMAISIDRYIAIVHPLRPR--LSRRTTKIAIAVIWLASFLLALPQLLYstTETYYYYTGSERTVCFIAWPD---- 159
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1343071534 188 acadtSQYELMVYVTGVIFL----LLPLSAIITSYSLI 221
Cdd:cd15390   160 -----GPNSLQDFVYNIVLFvvtyFLPLIIMAVAYTRV 192
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
29-221 8.80e-05

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 43.25  E-value: 8.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  29 ATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLG 108
Cdd:cd15928     5 AVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLVLPLDLYRLWRYRPWRFGDLLCRLMYFFSETCT 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 109 GAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALghtvytmhfPFCMSQEIRHLLCEVPPLLKLA 188
Cdd:cd15928    85 YASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAG---------PALVLVGVEHIQGQQTPRGFEC 155
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1343071534 189 CADTSQYEL---MVYVTGVIFlLLPLSAIITSYSLI 221
Cdd:cd15928   156 TVVNVSSGLlsvMLWVSTSFF-FVPMVCLSLLYGLI 190
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
34-221 8.99e-05

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 43.32  E-value: 8.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDL 113
Cdd:cd15978    10 IFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISVSVSTF 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 114 LLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVppllkLACADTS 193
Cdd:cd15978    90 NLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNLVPFTRINNSTGNMCRL-----LWPNDVT 164
                         170       180
                  ....*....|....*....|....*...
gi 1343071534 194 QYELMVYVTGVIFlLLPLSAIITSYSLI 221
Cdd:cd15978   165 QQSWYIFLLLILF-LIPGIVMMTAYGLI 191
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
26-157 9.23e-05

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 43.12  E-value: 9.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLrdNTISFEG--CALQLFS 103
Cdd:cd15061     1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLL--GYWPLGShlCDFWISL 78
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1343071534 104 AMTLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSAL 157
Cdd:cd15061    79 DVLLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITS 132
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
36-152 1.32e-04

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 42.88  E-value: 1.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  36 MLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLlftsVVTPNTVVDFLLRDNTISFEG----CALQLFSAMTLGGAE 111
Cdd:cd15387    12 FLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADL----VVAVFQVLPQLIWDITFRFYGpdflCRLVKYLQVVGMFAS 87
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1343071534 112 DLLLAFMAYDRYVAICHPLNYmifMSPKACRLMVAISWILA 152
Cdd:cd15387    88 TYMLLLMSIDRCLAICQPLRS---LHRRSDRVYVLFSWLLS 125
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
33-243 1.50e-04

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 42.74  E-value: 1.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  33 TLYMLALISNGLLLLVITVD-ARLHVPMYLLLRQLSLIDLLFTSVVTP-----NTVVDFLLRDntisfEGCALQLFSAMT 106
Cdd:cd15383     9 VLFVLSACSNLAVLWSATRNrRRKLSHVRILILHLAAADLLVTFVVMPldaawNVTVQWYAGD-----LACRLLMFLKLF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 107 LGGAEDLLLAFMAYDRYVAICHPLNymIFMSPKACRLMVAISWILASLSALGHTVytmhfpfcmsqeIRHLLCEVPPLLK 186
Cdd:cd15383    84 AMYSSAFVTVVISLDRHAAILNPLA--IGSARRRNRIMLCAAWGLSALLALPQLF------------LFHTVTATPPVNF 149
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1343071534 187 LACAD----TSQYELMVY--VTGVIFLLLPLSAIITSYSLILFTVLH-MPSNEGRKKALVTCSS 243
Cdd:cd15383   150 TQCAThgsfPAHWQETLYnmFTFFCLFLLPLLIMIFCYTRILLEISRrMKEKKDSAKNEVALRS 213
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
25-128 1.60e-04

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 42.51  E-value: 1.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  25 ELLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSA 104
Cdd:cd15078     1 ELLALLIATIGFLGVCNNLLVLILYYKFKRLRTPTNLLLVNISLSDLLVSLLGVTFTFMSCVRGRWVFDVAGCVWDGFSN 80
                          90       100
                  ....*....|....*....|....
gi 1343071534 105 MTLGGAEDLLLAFMAYDRYVAICH 128
Cdd:cd15078    81 SLFGIVSIMTLTVLAYERYIRVVH 104
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
27-225 1.99e-04

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 42.54  E-value: 1.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  27 LCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFT----SVVTPNTVVDFLLRDNTI-SFEGCALQL 101
Cdd:cd15084    13 VAVLMGMVVALASFVNGLVIVVSIKYKKLRSPLNYILVNLAVADLLVTlfgsSVSFSNNIVGFFVFGKTMcEFEGFMVSL 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 102 FSAMTLGGaedllLAFMAYDRYVAICHPLNYMIFMSPKA---CRLMVAISWILASLSALGHTVYtmhfpfcmsqeirhll 178
Cdd:cd15084    93 TGIVGLWS-----LAILAFERYLVICKPMGDFRFQQRHAvsgCAFTWGWSLLWTSPPLFGWSSY---------------- 151
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1343071534 179 ceVPPLLKLAC--------ADTSQYELMVYVTGVIfllLPLSAIITSYSLILFTV 225
Cdd:cd15084   152 --VPEGLRTSCgpnwytggTNNNSYILALFVTCFA---LPLSTIIFSYSNLLLTL 201
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
27-221 2.20e-04

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 42.13  E-value: 2.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  27 LCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVD------FLLRDNtisfeGCALQ 100
Cdd:cd15133     3 VCLTYLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMPLELYElwqnypFLLGSG-----GCYFK 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 101 LFSAMTLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTvyTMHFPFCMSQEI-RHLLC 179
Cdd:cd15133    78 TFLFETVCLASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVWGVSMLCALPNT--SLHGIKFLGSGVpASAQC 155
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1343071534 180 EVPPLLKLacadtsqYELMVYVTGVIFLLLPLSAIITSYSLI 221
Cdd:cd15133   156 TVRKPQAI-------YNMIPQHTGHLFFVLPMAVISVLYLLM 190
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
33-163 2.41e-04

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 42.08  E-value: 2.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  33 TLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTsVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAED 112
Cdd:cd15094     9 LICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFL-IGLPFLIVTMILKYWPFGAAMCKIYMVLTSINQFTSS 87
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1343071534 113 LLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYT 163
Cdd:cd15094    88 FTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYA 138
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
33-295 2.81e-04

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 42.03  E-value: 2.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  33 TLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAED 112
Cdd:cd15073     9 VAGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMASI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 113 LLLAFMAYDRYVAICHPLNYMIfMSPKACRLMVAISWILASLSALghtvytmhFPF----CMSQEIRHLLCEVppllKLA 188
Cdd:cd15073    89 GLLTVVAVDRYLTICRPDLGRK-MTTNTYTVMILLAWTNAFFWAA--------MPLvgwaSYALDPTGATCTI----NWR 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 189 CADTSqYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGM-FYGGATFM--------Y 259
Cdd:cd15073   156 KNDSS-FVSYTMSVIVVNFIVPLAVMFYCYYNVSRFVKKVLASDCLESVNIDWTDQNDVTKMsVIMIVMFLvawspysiV 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1343071534 260 VLPSSFHSPKQdniISVFYTIVTPAL-------NPLIYSLRNK 295
Cdd:cd15073   235 CLWASFGEPKK---IPPWMAIIPPLFaksstfyNPCIYVIANK 274
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
29-157 2.90e-04

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 41.68  E-value: 2.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  29 ATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLlftsVVTPNTVVDFLLRDNTISFEG----CALQLFSA 104
Cdd:cd15388     5 AVLAIIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADL----VVAFFQVLPQLVWDITDRFRGpdvlCRLVKYLQ 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1343071534 105 MTLGGAEDLLLAFMAYDRYVAICHPLnyMIFMSPKA-CRLMVAISWILASLSAL 157
Cdd:cd15388    81 VVGMFASSYMIVAMTFDRHQAICRPM--VTFQKGRArWNGPVCVAWAISLILSL 132
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
35-157 2.93e-04

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 41.89  E-value: 2.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  35 YMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEG-CALQLFSAMTLGGAEDL 113
Cdd:cd14997    11 FVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWAREPWLLGEFmCKLVPFVELTVAHASVL 90
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1343071534 114 LLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSAL 157
Cdd:cd14997    91 TILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSS 134
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
34-179 3.37e-04

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 41.72  E-value: 3.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDL 113
Cdd:cd15979    10 IFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSVSVSTF 89
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1343071534 114 LLAFMAYDRYVAICHPLNYMIFMS-PKACRLMVAiSWILASLSALGHTVYTMHFPFCMSQEIRHLLC 179
Cdd:cd15979    90 SLVAIAIERYSAICNPLQSRVWQTrSHAYRVIAA-TWLLSGLIMIPYPVYSVTVPVPVGDRPRGHQC 155
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
32-244 3.55e-04

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 41.44  E-value: 3.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  32 TTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTI---------SFEGCALqLF 102
Cdd:cd15203     8 GLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNWPFgsilcklvpSLQGVSI-FV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 103 SAMTLggaedlllAFMAYDRYVAICHPLNYMifMSPKACRLMVAISWILASLSALghtvytmhfPFCMSQEIRHLLCEVP 182
Cdd:cd15203    87 STLTL--------TAIAIDRYQLIVYPTRPR--MSKRHALLIIALIWILSLLLSL---------PLAIFQELSDVPIEIL 147
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1343071534 183 PLLKLACAD--TSQYELMVYVTGVIFL--LLPLSAIITSYSLILFtVLHMPSNEGRKKALVTCSSH 244
Cdd:cd15203   148 PYCGYFCTEswPSSSSRLIYTISVLVLqfVIPLLIISFCYFRISL-KLRKRVKKKRGKRTLSSRRR 212
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
31-151 4.15e-04

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 41.28  E-value: 4.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  31 VTTLYMLALISNGLLLLV-ITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLlrdNTISFEG---CALQLFSAMT 106
Cdd:cd15317     6 VLVLAMLITVSGNLVVIIsISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTV---ETCWYFGdlfCKFHTGLDLL 82
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1343071534 107 LGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWIL 151
Cdd:cd15317    83 LCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLV 127
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
26-150 4.46e-04

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 41.29  E-value: 4.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLL--VITVDARLHVPMYLLLrQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFS 103
Cdd:cd15219     1 LLAVLLVVVLVVSLLSNLLVLLcfLYSAELRKQVPGIFLL-NLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFL 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1343071534 104 AMTLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWI 150
Cdd:cd15219    80 ETFLTSNAMLSMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWL 126
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
43-182 4.88e-04

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 41.00  E-value: 4.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  43 GLLLLVITVD--ARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDLLLAFMAY 120
Cdd:cd15318    17 GNLFVVVTVShfKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFHLCFISI 96
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1343071534 121 DRYVAICHPLNY-MIFMSPKACRLmVAISWILAslsalghTVYTMHFPFCMSQEIR--HLLCEVP 182
Cdd:cd15318    97 DRHCAICDPLLYpSKFTIRVACIF-IAAGWLVP-------TVYTSVFLYTKAVEEGlaELLTSVP 153
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
26-156 5.93e-04

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 40.98  E-value: 5.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCatvTTLYMLALISNGLLLLVITVDARLH-VPMYLLLRQLSLIDLLfTSVVTPNTVVDFLLRDNTISFEGCALQLFSA 104
Cdd:cd15341     5 VLC---TLCGLLCILENVAVLYLILSSPKLRrKPSYLFIGSLALADFL-ASVVFACSFVDFHVFHGVDSSAIFLLKLGGV 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1343071534 105 MTLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSA 156
Cdd:cd15341    81 TMSFTASLGSLLLMAFDRYVCIYYPSEYKALVTRKRALVALAVMWVLTALIA 132
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
113-251 6.39e-04

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 40.73  E-value: 6.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 113 LLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILAslsalghtvYTMHFPFCMSQEI-------RHLLC-EVPPl 184
Cdd:cd15095    89 LTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVS---------FLLSIPVAIYYRLeegywygPQTYCrEVWP- 158
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1343071534 185 lklacADTSQYELMVYVTGVIFlLLPLSAIITSYSLILFTVLH-----------MPSNEGRKKALVTCSShLTVVGMF 251
Cdd:cd15095   159 -----SKAFQKAYMIYTVLLTY-VIPLAIIAVCYGLILRRLWRrsvdgnnqseqLSERALRQKRKVTRMV-IVVVVLF 229
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
37-154 6.84e-04

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 40.80  E-value: 6.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  37 LALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDLLLA 116
Cdd:cd15065    12 LAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCSTASILNLC 91
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1343071534 117 FMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASL 154
Cdd:cd15065    92 AISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSAL 129
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
23-163 7.41e-04

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 40.66  E-value: 7.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  23 SPELLcatvTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLF 102
Cdd:cd15353     3 SPEVF----VTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVVITLLNGNDTDAQSFTVNID 78
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1343071534 103 SAMTLGGAEDLL-----LAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYT 163
Cdd:cd15353    79 NVIDSVICSSLLasicsLLSIAVDRYFTIFYALQYHNIMTVRRAGVIITCIWTACTVSGVLFIIYS 144
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
32-221 7.85e-04

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 40.49  E-value: 7.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  32 TTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVV-DFLLRDNTISFEGCALQLFSAMTLGGA 110
Cdd:cd15394     8 SLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAyAFEPRGWVFGRFMCYFVFLMQPVTVYV 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 111 EDLLLAFMAYDRYVAICHPLNYMifMSPKACRLMVAISWILASLSALGHTVYTMHFPFcmsQEIRHLLCEvppllKLACA 190
Cdd:cd15394    88 SVFTLTAIAVDRYYVTVYPLRRR--ISRRTCAYIVAAIWLLSCGLALPAAAHTYYVEF---KGLDFSICE-----EFWFG 157
                         170       180       190
                  ....*....|....*....|....*....|.
gi 1343071534 191 DTSQYELMVYVTGVIFLLLPLSAIITSYSLI 221
Cdd:cd15394   158 QEKQRLAYACSTLLITYVLPLLAISLSYLRI 188
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
37-222 8.10e-04

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 40.51  E-value: 8.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  37 LALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFtsVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGG--AEDLL 114
Cdd:cd15088    13 VGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLF--MLGMPFLIHQFAIDGQWYFGEVMCKIITALDANNqfTSTYI 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 115 LAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLlcEVPPllklacaDTSQ 194
Cdd:cd15088    91 LTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVYSSLIYFPDGTTFCYV--SLPS-------PDDL 161
                         170       180
                  ....*....|....*....|....*...
gi 1343071534 195 YELMVYVTGVIFlLLPLSAIITSYSLIL 222
Cdd:cd15088   162 YWFTIYHFILGF-AVPLVVITVCYILIL 188
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
27-221 8.79e-04

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 40.52  E-value: 8.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  27 LCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVD------FLLRDNtisfeGCALQ 100
Cdd:cd15358     3 VCVTYLLIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLGMPLELYEmwsnypFLLGAG-----GCYFK 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 101 LFSAMTLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTvyTMHFPFCMSQEIRHLLCE 180
Cdd:cd15358    78 TLLFETVCFASILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVVSILCSIPNT--SLHGIFQLTVPCRGPVPD 155
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1343071534 181 VPPLLKLACADTsqYELMVYVTGVIFLLLPLSAIITSYSLI 221
Cdd:cd15358   156 SATCMLVKPRWM--YNLIIQITTLLFFFLPMGTISVLYLLI 194
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
30-225 1.09e-03

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 40.11  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  30 TVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFL----LRDNTIsfegCALQLFSAM 105
Cdd:cd15384     6 VLAVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPSEAIWAYtvawLAGNTM----CKLVKYLQV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMifMSPKACRLMVAISWILASLsalghtvytmhfpFCMSQE-IRHLLCEVPPL 184
Cdd:cd15384    82 FGLYLSTYITVLISLDRCVAILYPMKRN--QAPERVRRMVTVAWILSPI-------------FSIPQAvIFHVERGPFVE 146
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1343071534 185 LKLACAD----TSQYELMVYVTGVIFL--LLPLSAIITSYSLILFTV 225
Cdd:cd15384   147 DFHQCVTygfyTAEWQEQLYNMLSLVFmfPIPLVIMVTCYVLIFITL 193
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
27-162 1.15e-03

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 40.07  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  27 LCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMT 106
Cdd:cd15208     3 LIALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQTV 82
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1343071534 107 LGGAEDLLLAFMAYDRYVAICHPLnyMIFMSPKACRLMVAISWILASLSALGHTVY 162
Cdd:cd15208    83 SVSVSVLTLSCIALDRWYAICHPL--MFKSTAKRARVSILIIWIVSLLIMIPQAIV 136
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
33-151 1.15e-03

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 39.96  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  33 TLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAED 112
Cdd:cd15330     9 TLILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSI 88
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1343071534 113 LLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWIL 151
Cdd:cd15330    89 LHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLI 127
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
34-251 1.32e-03

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 39.99  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNgLLLLVITVDARLH--VPMYLLLRQLSLIDLLFTSVVTPNTVV----------DFLLRdntisfegcALQL 101
Cdd:cd15382    10 LFLIAAVGN-LTVLLILLRNRRRkrSRVNILLMHLAIADLLVTFIMMPLEIGwaatvawlagDFLCR---------LMLF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 102 FSAMTLGGAEDLLLAfMAYDRYVAICHPLNymIFMSPKACRLMVAISWILASLSALGHTvytmhFPFCMSQEIRHLLCEv 181
Cdd:cd15382    80 FRAFGLYLSSFVLVC-ISLDRYFAILKPLR--LSDARRRGRIMLAVAWVISFLCSIPQS-----FIFHVESHPCVTWFS- 150
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1343071534 182 ppllklACAD-----TSQYELMVYVTGVIFL-LLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGMF 251
Cdd:cd15382   151 ------QCVTfnffpSHDHELAYNIFNMITMyALPLIIIVFCYSLILCEISRKSKEKKEDVSEKSSSVRLRRSSVG 220
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
34-225 1.33e-03

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 39.83  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVvtpNTVVDFLLRDNTISFEG---CALQLFSAMTLGGA 110
Cdd:cd16004    10 IVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAF---NTAFNFVYASHNDWYFGlefCRFQNFFPITAMFV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 111 EDLLLAFMAYDRYVAICHPLNYMifMSPKACRLMVAISWILAslsalghtvYTMHFPFCMSQEIRHLLCEVPPLLKLAcA 190
Cdd:cd16004    87 SIYSMTAIAADRYMAIIHPFKPR--LSAGSTKVVIAGIWLVA---------LALAFPQCFYSTVTMDQGRTKCIVAWP-G 154
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1343071534 191 DTSQYELMVYVTGVIFL--LLPLSAIITSYSLILFTV 225
Cdd:cd16004   155 DSGGKHQLTYHLAVIVLiyLLPLAVMFVTYSIIGITL 191
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
34-295 1.45e-03

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 39.60  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTP-NTVVDFLLRDNTISFEGCALQLFSAMTLGGAED 112
Cdd:cd15052    10 LVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPlSILTELFGGVWPLPLVLCLLWVTLDVLFCTASI 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 113 LLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIrhllcevppllklACADT 192
Cdd:cd15052    90 MHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSPIPVLGIIDTTNVLNNG-------------TCVLF 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 193 SQYeLMVYVTGVIFLLlPLSAIITSYSLilftVLHMPSNEgRKKALVTCSSHLTVVGMF--YGGATFMYVLPSSFHSPKQ 270
Cdd:cd15052   157 NPN-FVIYGSIVAFFI-PLLIMVVTYAL----TIRLLSNE-QKASKVLGIVFAVFVICWcpFFITNILTGLCEECNCRIS 229
                         250       260
                  ....*....|....*....|....*..
gi 1343071534 271 DNIISVFYTI--VTPALNPLIYSLRNK 295
Cdd:cd15052   230 PWLLSVFVWLgyVSSTINPIIYTIFNK 256
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
27-162 1.51e-03

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 39.52  E-value: 1.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  27 LCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMT 106
Cdd:cd15321     9 IAAAITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALDVL 88
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1343071534 107 LGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVY 162
Cdd:cd15321    89 FCTSSIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIY 144
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
36-231 1.64e-03

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 39.50  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  36 MLALISN-GLLLLVITVDARLHVPmYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDLL 114
Cdd:cd15124    12 LIGLIGNiTLIKIFCTVKSMRNVP-NLFISSLALGDLLLLVTCAPVDASRYLADEWLFGRVGCKLIPFIQLTSVGVSVFT 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 115 LAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEIRHLLCEVPpllkLACADTSQ 194
Cdd:cd15124    91 LTALSADRYKAIVRPMDIQASNALMKICLKAALIWILSMLLAIPEAVFSDLHPFYDKSTNKTFVSCAP----YPHSNELH 166
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1343071534 195 YELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSN 231
Cdd:cd15124   167 PKIHSMASFLIFYVIPLSIISVYYYFIAKNLIRSAYN 203
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
37-225 1.72e-03

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 39.57  E-value: 1.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  37 LALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDLLLA 116
Cdd:cd15074    13 LSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFGCCSINTLT 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 117 FMAYDRYVAICHPlNYMIFMSPKACRLMVAISWILASLSA----LGHTVYTMhfpfcmsqEIRHLLCEVPplLKLACADT 192
Cdd:cd15074    93 AISIYRYLKICHP-PYGPKLSRRHVCIVIVAIWLYALFWAvaplVGWGSYGP--------EPFGTSCSID--WTGASASV 161
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1343071534 193 SQyelMVYVTGVIFL--LLPLSAIITSYSLILFTV 225
Cdd:cd15074   162 GG---MSYIISIFIFcyLLPVLIIVFSYVKIIRKV 193
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
26-152 1.84e-03

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 39.23  E-value: 1.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd15049     2 LICIATGSLSLVTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGYWPLGPLLCDLWLALDY 81
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILA 152
Cdd:cd15049    82 VASNASVMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVIS 128
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
26-152 2.22e-03

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 39.18  E-value: 2.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd17790     2 LIVITTGILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDY 81
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILA 152
Cdd:cd17790    82 VASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLIS 128
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
36-294 2.40e-03

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 38.95  E-value: 2.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  36 MLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDLLL 115
Cdd:cd15000    11 LFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGFLEGSLLLASVLAL 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 116 AFMAYDRYVAICHPLNYMIfmSPKACRLMVAISWILASLSALghtvytmhfPFCMSQEIRHLlcEVPPLLKLACA-DTSQ 194
Cdd:cd15000    91 CAVSYDRLTAIVLPSEARL--TKRGAKIVIVITWIVGLLLAL---------PLAIYRSYRER--QWKNFLETYCAeNTQV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 195 YELMVYVTGVIFLLLPLSAIITSYSLILFTVLHM---------PSNEGRKK-----------ALVTCSSHLTVVGMFY-- 252
Cdd:cd15000   158 LPIYWHVIITVLVWLPLGIMLICYSAIFWKLDKYerrvlrrehPSVVRYKKkaaktlfivliTFVVCRIPFTALIFYRyk 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1343071534 253 --GGATFMYVLPSSFHSPKqdnIISVFYTIVTPALNPLIYSLRN 294
Cdd:cd15000   238 lvPNDNTQNSVSGSFHILW---FASKYLMFLNAAVNPLIYGFTN 278
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
33-153 2.46e-03

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 38.76  E-value: 2.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  33 TLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQ----LFSAM--- 105
Cdd:cd15354     9 TLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHLVIEDAFVRhidnVFDSLici 88
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1343071534 106 TLGGAEDLLLAfMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILAS 153
Cdd:cd15354    89 SVVASMCSLLA-IAVDRYVTIFYALRYHNIMTVRRAGIIIACIWTFCT 135
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
26-156 2.53e-03

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 39.02  E-value: 2.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd15054     2 WVAAFLCLIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDV 81
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSA 156
Cdd:cd15054    82 MCCSASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALAS 132
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
38-224 2.68e-03

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 38.95  E-value: 2.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  38 ALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDLLLAF 117
Cdd:cd14992    14 SVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTVSVYASSLTLTA 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 118 MAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFP-FCMSQEIRHLLCEVPPllklacaDTSQYE 196
Cdd:cd14992    94 IAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVlFSVKNQEKIFCCQIPP-------VDNKTY 166
                         170       180       190
                  ....*....|....*....|....*....|.
gi 1343071534 197 LMVY---VTGVIFlLLPLSAIITSYSLILFT 224
Cdd:cd14992   167 EKVYfllIFVVIF-VLPLIVMTLAYARISRE 196
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
63-214 2.72e-03

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 38.77  E-value: 2.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  63 LRQLSLIDLLFTSVVTPNTVVDFLLRDNTISF--EGCALQLFSAMTLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKA 140
Cdd:cd15130    42 LGSLALSDLLILLLAMPVELYNFIWVHHPWAFgdAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSR 121
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1343071534 141 CRLMVAISWILASLSALghtvytmhfPFCMSQEIRHLLCEVPPLLKLACA---DTSQYELMVYVTGVIFLLLPLSAI 214
Cdd:cd15130   122 TKKFISAIWLASALLAI---------PMLFTMGLQNESDDGTHPGGLVCTpivDTATLKVVIQVNTFMSFLFPMLVT 189
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
34-158 2.83e-03

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 38.62  E-value: 2.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDL 113
Cdd:cd15062    10 FILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLCCTASIM 89
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1343071534 114 LLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALG 158
Cdd:cd15062    90 SLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIG 134
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
32-157 2.94e-03

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 38.88  E-value: 2.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  32 TTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRD---------NTISFEGCALQLF 102
Cdd:cd15392     8 STIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFIALLILQywpfgefmcPVVNYLQAVSVFV 87
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1343071534 103 SAMTLggaedlllAFMAYDRYVAICHPLNymIFMSPKACRLMVAISWILASLSAL 157
Cdd:cd15392    88 SAFTL--------VAISIDRYVAIMWPLR--PRMTKRQALLLIAVIWIFALATAL 132
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
33-222 3.15e-03

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 38.51  E-value: 3.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  33 TLYMLA----LISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFtsVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLG 108
Cdd:cd14985     5 ALYIAIflvgLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVF--VLTLPLWATYTANQYDWPFGAFLCKVSSYVISV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 109 G--AEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALghtvytmhfPFCMSQEIRhllcEVPPLLK 186
Cdd:cd14985    83 NmfASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSL---------PTFLLRSLQ----AIENLNK 149
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1343071534 187 LACA---DTSQYELMVYVTGVIF-LLLPLSAIITSYSLIL 222
Cdd:cd14985   150 TACImlyPHEAWHFGLSLELNILgFVLPLLIILTCYFHIA 189
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
115-153 3.25e-03

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 38.78  E-value: 3.25e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1343071534 115 LAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILAS 153
Cdd:cd15089    90 LTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSS 128
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
115-237 3.30e-03

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 38.55  E-value: 3.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 115 LAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPFCMSQEirHLLC-EVPPllklacaDTS 193
Cdd:cd15098    93 LVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVAVHQDLVHHWTASN--QTFCwENWP-------EKQ 163
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1343071534 194 QYELMVYVTGVIFLLLPLSAIITSYSLILFTvLHMPSNEGRKKA 237
Cdd:cd15098   164 QKPVYVVCTFVFGYLLPLLLITFCYAKVLNH-LHKKLKNMSKKS 206
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
34-240 3.42e-03

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 38.64  E-value: 3.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVtPNTVVDFLLRDNTISFE-GCALQLFSAMTLGGAED 112
Cdd:cd15921    10 IFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLLVCTL-PLRLTYYVLNSHWPFGDiACRIILYVLYVNMYSSI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 113 LLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALghtvytmhfPFCMSQEIRHLLcEVPPLLKLACADT 192
Cdd:cd15921    89 YFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASS---------PLLFAKSKQHDE-GSTRCLELAHDAV 158
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1343071534 193 SQYELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEG-----RKKALVT 240
Cdd:cd15921   159 DKLLLINYVTLPVGFVVPFMTVIFCYIFIIKNLLKPSPALGrtrpsRRKACAL 211
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
36-147 3.63e-03

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 38.30  E-value: 3.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  36 MLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLF-----TSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGa 110
Cdd:cd15085    12 TFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMalcgtTIVTVTNYEGYFYLGDAFCIFQGFAVNYFGIVSLWS- 90
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1343071534 111 edllLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAI 147
Cdd:cd15085    91 ----LTLLAYERYNVVCKPMGGLKLSTKRGYQGLLFI 123
7tmA_PGI2 cd15141
prostaglandin I2 receptor, member of the class A family of seven-transmembrane G ...
21-154 3.85e-03

prostaglandin I2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin I2 receptor (also called prostacyclin receptor or prostanoid IP receptor) is a class A, G protein-coupled receptor whose endogenous ligand is prostacyclin, which is the major product of cyclooxygenase metabolite of arachidonic acid that found predominantly in platelets and vascular smooth muscle cells (VSMCs). The PGI2 receptor is coupled to both G(s) and G(q) protein subtypes, resulting in increased cAMP formation, phosphoinositide turnover, and Ca2+ signaling. PGI2 receptor activation by prostacyclin induces VSMC differentiation and produces a potent vasodilation and inhibition of platelet aggregation.


Pssm-ID: 320269 [Multi-domain]  Cd Length: 301  Bit Score: 38.26  E-value: 3.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  21 SGSPellcATVTTLYMLALISNGLLLLVITVDAR----LHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEG 96
Cdd:cd15141     1 DGHP----ATSTLMFAAGVVGNLLALGILGVHRKerrtKSSAFCVLVTGLAATDLLGTCFLSPMVFVSYAQNSSLLGLAA 76
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1343071534  97 ----CALQLFSAMTLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASL 154
Cdd:cd15141    77 gqplCHLFAFAMTFFGLASMLILFAMAVERCLAISHPYFYAQHSGRRLAKLALPAIYAFGAL 138
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
34-240 5.10e-03

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 37.83  E-value: 5.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFtsVVT-PNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEd 112
Cdd:cd15179    10 IFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLF--VLTlPFWAVDAAANWYFGNFLCKAVHVIYTVNLYSSV- 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 113 LLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMhfpfcMSQEIRHLLCEvppllKLACADT 192
Cdd:cd15179    87 LILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWLPALLLTVPDLVFAK-----VSELDDRYICD-----RIYPEDT 156
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1343071534 193 SQYELMVY--VTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVT 240
Cdd:cd15179   157 FELWVVAFrfQHILVGLVLPGLVILTCYCIIISKLSHSKGHQKRKALKTT 206
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
26-150 5.22e-03

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 38.08  E-value: 5.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd15051     2 VLGVVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPLGPVFCNIYISLDV 81
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWI 150
Cdd:cd15051    82 MLCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWV 126
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
26-152 5.34e-03

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 38.02  E-value: 5.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd15297     2 FIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDY 81
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILA 152
Cdd:cd15297    82 VVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLS 128
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
31-154 5.47e-03

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 37.75  E-value: 5.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  31 VTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLL-FTSVVTPNTVVDFLLRDNTI-SFEGCALQLFSAMTLG 108
Cdd:cd14995     7 VLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMvLVAAGLPNEIESLLGPDSWIyGYAGCLLITYLQYLGI 86
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1343071534 109 GAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASL 154
Cdd:cd14995    87 NASSLSITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSL 132
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
34-234 5.73e-03

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 38.01  E-value: 5.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  34 LYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAMTLGGAEDL 113
Cdd:cd15307    10 LVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCTASIM 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 114 LLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMHFPfcmSQEIRHLLCEVP-PLLKLacadt 192
Cdd:cd15307    90 HLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKDH---ASVLVNGTCQIPdPVYKL----- 161
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1343071534 193 sqyelmvyVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGR 234
Cdd:cd15307   162 --------VGSIVCFYIPLGVMLLTYCLTVRLLARQRSRHGR 195
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
31-295 6.02e-03

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 37.60  E-value: 6.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  31 VTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDN-TISFEGCALQLFSAMTLGG 109
Cdd:cd15304     7 TVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRwPLPSKLCAVWIYLDVLFST 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 110 AEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILAslsalghTVYTMHFPFCMSQEIRHLLCEVPPLLklac 189
Cdd:cd15304    87 ASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTIS-------VGISMPIPVFGLQDDSKVFKEGSCLL---- 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 190 ADtsqyELMVYVTGVIFLLLPLSAIITSYSLILFTVLHMPSNEGRKKALVTCSSHLTVVGM--FYGGATFMYVLPSSFHS 267
Cdd:cd15304   156 AD----ENFVLIGSFVAFFIPLTIMVITYFLTIKSLQQSISNEQKASKVLGIVFFLFVVMWcpFFITNVMAVICKESCNE 231
                         250       260       270
                  ....*....|....*....|....*....|
gi 1343071534 268 PKQDNIISVFYTI--VTPALNPLIYSLRNK 295
Cdd:cd15304   232 VVIGGLLNVFVWIgyLSSAVNPLVYTLFNK 261
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
33-163 6.36e-03

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 37.56  E-value: 6.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  33 TLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQL----FSAMTLG 108
Cdd:cd15352     9 TLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLETIMIAVLNSGYLVISDQFIQHmdnvFDSMICI 88
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1343071534 109 G--AEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYT 163
Cdd:cd15352    89 SlvASICNLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWVVCIVCGIVFIVYS 145
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
35-251 7.40e-03

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 37.45  E-value: 7.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  35 YMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFtSVVTPNTVVDFLLRDNTISFE-GCALQLFSAMTLGGAEDL 113
Cdd:cd15968    11 FLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLY-ALSLPLLIYNYAMRDRWLFGDfMCRLVRFLFYFNLYGSIL 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 114 LLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILaslsALGHTVYTMHFPFCMSQEIRHLLCEVPPllklaCADTS 193
Cdd:cd15968    90 FLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWIL----VFAQTLPILIFARTGIIRNRTVCYDLAP-----PALFP 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1343071534 194 QYELMVYVTGVIFLLLPLSAIITSYSLILFTVL------HMPSNEGRKKALVTCsshLTVVGMF 251
Cdd:cd15968   161 HYVPYGMALTVSGFLLPFSIILWCYCLVVRTLCrtlgpaEPPAQARRRKSIRTI---VTVTLLF 221
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
26-165 7.87e-03

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 37.16  E-value: 7.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  26 LLCATVTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCALQLFSAM 105
Cdd:cd15324     2 LIVLVVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDV 81
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534 106 TLGGAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSALGHTVYTMH 165
Cdd:cd15324    82 LFCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLLMTKH 141
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
31-156 9.59e-03

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 37.13  E-value: 9.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  31 VTTLYMLALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTP----NTVVDFLLRDNtiSFEGCALQLFSAMT 106
Cdd:cd15215     6 IVIFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPwviaTSVPLFWPLDS--HLCTALVVLMHLFA 83
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1343071534 107 LGGAEDLLLafMAYDRYVAICHPLNYMIFMSPKACRLMVAISWILASLSA 156
Cdd:cd15215    84 FAGVNTIVV--VSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQS 131
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
29-151 9.96e-03

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 36.86  E-value: 9.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343071534  29 ATVTTLYM-LALISNGLLLLVITVDARLHVPMYLLLRQLSLIDLLFTSVVTPNTVVDFLLRDNTISFEGCalQLFSAMTL 107
Cdd:cd15210     4 AVWGIVFMvVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLC--RVFPLLRY 81
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1343071534 108 G--GAEDLLLAFMAYDRYVAICHPLNYMIFMSPKACRLMVAISWIL 151
Cdd:cd15210    82 GlvAVSLLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIF 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH