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Conserved domains on  [gi|1333886298|ref|NP_001346906|]
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solute carrier family 49 member A3 isoform 2 [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 2-248 2.37e-91

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17399:

Pssm-ID: 475125  Cd Length: 419  Bit Score: 278.38  E-value: 2.37e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298   2 MLGIYIGPAALACLLATVCLWESVPPTPPSTGAANStSESFLRGLKLLIQNKAYVLLAVCFGGGIGVFSSFSALLEQILC 81
Cdd:cd17399   169 LLSIYTIPALIAVVLATFGVRSSVPPTPPSASAAHE-SEPFFVGLKQLFKNKQYLILMLCFGGGIGLFNALSTLLEQILC 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298  82 ASGYSNEFSGLCGALFIVFGILGALLLGLYVDRTKHFTEATKIGLCLTSMTSVAFALVSQLQGQTLALAAICSLFGLFGF 161
Cdd:cd17399   248 PSGYSNNFAGICGALMIGVGLIGAFVAGLIVDKTKKFIEVTKVCFCLAVIFLVAFLVVSRFPNQSVLLAVLCGLFGFFGF 327

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298 162 SVAPVVMELAVECSFPVGEGASAGLIFVLGQAEGMLIMLLLTALTVR-----RTGPSFSTCQQGEDPLDWTVSLLLLAGL 236
Cdd:cd17399   328 AIYPVGLELAVECTYPVAEATSTGLIFMSGQIQGIILVFIMQALATPlsvydLPIQCASSASGNITPLDWTVPLLVMAGL 407

                         250
                  ....*....|..
gi 1333886298 237 CTLFTCVLVIFF 248
Cdd:cd17399   408 AAVLAIIFVVFF 419
 
Name Accession Description Interval E-value
MFS_MFSD7 cd17399
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily ...
 2-248 2.37e-91

Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily domain-containing protein 7 (MFSD7) is also called myosin light polypeptide 5 regulatory protein (MYL5). It's function is unknown. It is encoded by the a SLC49A3 gene and is a member of the Solute carrier 49 (SLC49) family, which also includes feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1), FLVCR2 (SLC49A2), as well as disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. MFSD7 belongs to the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340957  Cd Length: 419  Bit Score: 278.38  E-value: 2.37e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298   2 MLGIYIGPAALACLLATVCLWESVPPTPPSTGAANStSESFLRGLKLLIQNKAYVLLAVCFGGGIGVFSSFSALLEQILC 81
Cdd:cd17399   169 LLSIYTIPALIAVVLATFGVRSSVPPTPPSASAAHE-SEPFFVGLKQLFKNKQYLILMLCFGGGIGLFNALSTLLEQILC 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298  82 ASGYSNEFSGLCGALFIVFGILGALLLGLYVDRTKHFTEATKIGLCLTSMTSVAFALVSQLQGQTLALAAICSLFGLFGF 161
Cdd:cd17399   248 PSGYSNNFAGICGALMIGVGLIGAFVAGLIVDKTKKFIEVTKVCFCLAVIFLVAFLVVSRFPNQSVLLAVLCGLFGFFGF 327

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298 162 SVAPVVMELAVECSFPVGEGASAGLIFVLGQAEGMLIMLLLTALTVR-----RTGPSFSTCQQGEDPLDWTVSLLLLAGL 236
Cdd:cd17399   328 AIYPVGLELAVECTYPVAEATSTGLIFMSGQIQGIILVFIMQALATPlsvydLPIQCASSASGNITPLDWTVPLLVMAGL 407

                         250
                  ....*....|..
gi 1333886298 237 CTLFTCVLVIFF 248
Cdd:cd17399   408 AAVLAIIFVVFF 419
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
10-193 1.90e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 42.65  E-value: 1.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298  10 AALACLLATVCLWESVPPTPPSTGAANSTSESFLRGLKLLIQnkAYVLLAVCFGGGIGVFSSFSALLEQILcasGYSNEF 89
Cdd:COG2814   170 NAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLL--LLLLAFLLGFGFFALFTYLPLYLQEVL---GLSASA 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298  90 SGLCGALFIVFGILGALLLGLYVDRTKHFTeATKIGLCLTSMTSVAFALVSQLqgqtLALAAICSLFGLFGFSVAPVVME 169
Cdd:COG2814   245 AGLLLALFGLGGVLGALLAGRLADRFGRRR-LLLIGLLLLALGLLLLALAGSL----WLLLLALFLLGFGFGLLFPLLQA 319

                         170       180
                  ....*....|....*....|....
gi 1333886298 170 LAVECSFPVGEGASAGLIFVLGQA 193
Cdd:COG2814   320 LVAELAPPEARGRASGLYNSAFFL 343
MFS_1 pfam07690
Major Facilitator Superfamily;
10-197 6.36e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 40.86  E-value: 6.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298  10 AALACLLATVCLWESVPPTPPSTGAANSTSESFLRGLKLLIQNKAYVLLAVCFGGGIGVFSSFSALLEQILCASGYSNEF 89
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALL 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298  90 SGLCGALFIVFGILGALLLGLYVDRTKHFTeATKIGLCLTSMTSVAFALVSqLQGQTLALAAICSLFGLFGFSVAPVVME 169
Cdd:pfam07690 237 AGLLLGLGGLLGAIGRLLLGRLSDRLGRRR-RLLLALLLLILAALGLLLLS-LTLSSLWLLLALLLLGFGFGLVFPALNA 314

                         170       180
                  ....*....|....*....|....*...
gi 1333886298 170 LAVECSFPVGEGASAGLIFVLGQAEGML 197
Cdd:pfam07690 315 LVSDLAPKEERGTASGLYNTAGSLGGAL 342
 
Name Accession Description Interval E-value
MFS_MFSD7 cd17399
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily ...
 2-248 2.37e-91

Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily domain-containing protein 7 (MFSD7) is also called myosin light polypeptide 5 regulatory protein (MYL5). It's function is unknown. It is encoded by the a SLC49A3 gene and is a member of the Solute carrier 49 (SLC49) family, which also includes feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1), FLVCR2 (SLC49A2), as well as disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. MFSD7 belongs to the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340957  Cd Length: 419  Bit Score: 278.38  E-value: 2.37e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298   2 MLGIYIGPAALACLLATVCLWESVPPTPPSTGAANStSESFLRGLKLLIQNKAYVLLAVCFGGGIGVFSSFSALLEQILC 81
Cdd:cd17399   169 LLSIYTIPALIAVVLATFGVRSSVPPTPPSASAAHE-SEPFFVGLKQLFKNKQYLILMLCFGGGIGLFNALSTLLEQILC 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298  82 ASGYSNEFSGLCGALFIVFGILGALLLGLYVDRTKHFTEATKIGLCLTSMTSVAFALVSQLQGQTLALAAICSLFGLFGF 161
Cdd:cd17399   248 PSGYSNNFAGICGALMIGVGLIGAFVAGLIVDKTKKFIEVTKVCFCLAVIFLVAFLVVSRFPNQSVLLAVLCGLFGFFGF 327

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298 162 SVAPVVMELAVECSFPVGEGASAGLIFVLGQAEGMLIMLLLTALTVR-----RTGPSFSTCQQGEDPLDWTVSLLLLAGL 236
Cdd:cd17399   328 AIYPVGLELAVECTYPVAEATSTGLIFMSGQIQGIILVFIMQALATPlsvydLPIQCASSASGNITPLDWTVPLLVMAGL 407

                         250
                  ....*....|..
gi 1333886298 237 CTLFTCVLVIFF 248
Cdd:cd17399   408 AAVLAIIFVVFF 419
MFS_SLC49 cd17334
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ...
 2-248 4.55e-53

Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340892 [Multi-domain]  Cd Length: 407  Bit Score: 179.13  E-value: 4.55e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298   2 MLGIYIGPAALACLLATVCLWESVPPTPPSTGAANSTSE-------SFLRGLKLLIQNKAYVLLAVCFGGGIGVFSSFSA 74
Cdd:cd17334   166 FGAVFYGEFGFACLLLALVLALFPPKPKYPPSAASARQQnsehvilELQKSISELLRNEPFVLLAVAFSIMMGVFAGFSS 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298  75 LLEQILCASGYSNEFSGLCGALFIVFGILGALLLGLYVDRTKHFTEATKIGLCLTSMTSVAFALVSQ---LQGQTLALAA 151
Cdd:cd17334   246 VLAQILLPFGVSQTSAGWLGFFGIVAGMVGGLLLGLFVDRTRMFKLIGLIILALGTVVCTFFMLLVDrygLPYVTLAFYL 325

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298 152 ICSLFGLFGFSVAPVVMELAVECSFPVGEGASAGLIFVLGQAEGMLIMLLLTALTVrrtgpsfstcqqgedPLDWTVSLL 231
Cdd:cd17334   326 LCGLLGFFQNSMVPIMFELAVELTYPVPESVSTGVLTALANLFSFLLMLVFSELLG---------------PTPTESKYL 390

                         250
                  ....*....|....*..
gi 1333886298 232 LLAGLCTLFTCVLVIFF 248
Cdd:cd17334   391 LWFILCTVGSCLGALFF 407
MFS_FLVCR_like cd17398
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ...
 6-205 5.72e-21

Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340956 [Multi-domain]  Cd Length: 406  Bit Score: 92.30  E-value: 5.72e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298   6 YIGPAAL--ACLLATVCLWESVPPTPPSTGAA-----NSTSESFLRGLKLLIQNKAYVLLAVCFGGGIGVFSSFSALLEQ 78
Cdd:cd17398   172 FYGVAGIctALFILVIIFFKEKPPIPPSRAQAaaqelRSEDQSYLGSLKRLFKNKGFLLLLITYGINTGVYYAISTLLNQ 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298  79 -ILCASGYSNEFSGLCGALFIVFGILGALLLGLYVDRTKHFTEATkIGLCLTSMTSVAFALVSQLQGQTLALAAICSLFG 157
Cdd:cd17398   252 mVLEYFPNEEVNAGWIGLTLVIAGLVGSVVAGIWLDKTKKYKETT-IIVYILSFIGMVAFTFTLDLGSIWVVFLTAGALG 330

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1333886298 158 LFGFSVAPVVMELAVECSFPVGEGASAGLIFVLGQAEGMLIMLLLTAL 205
Cdd:cd17398   331 FFMTGYLPVGFEFAAELTYPEPEGTSSGLLNASAQIFGIIFTLVMGAL 378
MFS_DIRC2 cd17397
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; ...
 7-203 2.03e-15

Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; Disrupted in renal carcinoma protein 2 or disrupted in renal cancer protein 2 (DIRC2), encoded by the SLC49A4 gene, was initially identified as a breakpoint-spanning gene in a chromosomal translocation associated with the development of renal cancer. It is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. DIRC2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340955 [Multi-domain]  Cd Length: 381  Bit Score: 76.18  E-value: 2.03e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298   7 IGPAAL---------ACLLATVCLWESVPPTPPSTgAANSTSESFLRGLKLLIQNKAYVLLAVCFGGGIGVFSSFSALLE 77
Cdd:cd17397   151 IGPLVLmylefgwsaLIFLAMLIYFPSKPPTPPSV-SASTQRLSYKSGILSLLKNKRFWLIALAYGIPTGVYAGWSGVLD 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298  78 QILCASGYSNEFSGLCGALFIVFGILGALLLGLYVDRTKHFTEatKIGLCLTSMTSVAFALVSQLQ-----GQTLALAAI 152
Cdd:cd17397   230 VNLTPFGVSQVEAGWIGFYSTVAGCVGGIIVGRFADRFGGRMK--LILLLLFSGATGSFLWFTLIClkllpFSTVSLYTS 307

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1333886298 153 CSLFGLFGFSVAPVVMELAVECSFPVGEGASAGLIFVLGQAEGMLIMLLLT 203
Cdd:cd17397   308 CILLGVFLNGSVPLFYELAVEAAYPVPEGITSGVLTFLNNVFGLVFLLILI 358
MFS_FLVCR1 cd17455
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator ...
 5-206 4.18e-11

Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 1 (FLVCR1) is also called feline leukemia virus subgroup C receptor (FLVCR). FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. Mutations in the FLVCR1 gene have been linked to vision impairment, posterior column ataxia, and sensory neurodegeneration with loss of pain perception. FLVCR1 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341013  Cd Length: 407  Bit Score: 63.31  E-value: 4.18e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298   5 IYIGPAALACLL--ATVCLWESVPPTPPSTGAA-----NSTSESFLRGLKLLIQNKAYVLLAVCFGGGIGVFSSFSALLE 77
Cdd:cd17455   172 MFYGTAAVSTLLfiLTIIVFKEKPPLPPSQAQAvlqgiPSEDYSYKQSIINLFKNVPFVLLLISYGIMTGTFYSVSTLLN 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298  78 QILCASGYSNEF-SGLCGALFIVFGILGALLLGLYVDRTKHFTEATKIGLCLTSMTSVAFALVSQLqGQTLALAAICSLF 156
Cdd:cd17455   252 QMIITHYEGEEVnAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVVFTFTLDL-GYLIVVFVTGGVL 330

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1333886298 157 GLFGFSVAPVVMELAVECSFPVGEGASAGLIFVLGQAEGMLIMLLLTALT 206
Cdd:cd17455   331 GFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGIIFTLIQGKLT 380
MFS_FLVCR2 cd17456
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator ...
 5-197 2.16e-10

Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 2 (FLVCR2) is also called calcium-chelate transporter (CCT). It functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. Mutations in the FLVCR2 gene cause Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH), also known as Fowler syndrome, a rare autosomal recessive disorder characterized by glomerular vasculopathy in the central nervous system, severe hydrocephaly, hypokinesia and arthrogryphosis. FLVCR2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341014  Cd Length: 406  Bit Score: 60.95  E-value: 2.16e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298   5 IYIGPAALACLL--ATVCLWESVPPTPPSTGAA-----NSTSESFLRGLKLLIQNKAYVLLAVCFGGGIGVFSSFSALLE 77
Cdd:cd17456   171 MFYGTAAVATLLfiLVIIVFQEKPKIPPSQAQAaiqsiPSQDYSYLQSILRLLKNVNFILLVVSYGLNTGCFYALSTLLN 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298  78 QILCASGYSNEFS-GLCGALFIVFGILGALLLGLYVDRTKHFTEATKIGLCLTSMTSVAFALvsqlqgqTLALAAICSLF 156
Cdd:cd17456   251 RMVIFHYPGEEVNaGRIGLTIVVAGMVGALISGIWLDRTKTYKQTTLAVYIMSLVGMVVYTF-------TLNLGHLWVVF 323

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1333886298 157 ---GLFGFSVA---PVVMELAVECSFPVGEGASAGLIFVLGQAEGML 197
Cdd:cd17456   324 itaGTLGFFMTgylPLGFEFAAELTYPESEGTSSGLLNVSAQVFGII 370
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 10-214 3.00e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 48.19  E-value: 3.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298  10 AALACLLATVCLWESVPPTPPSTGAANSTSE--SFLRGLKLLIQNKAYVLLA-VCFGGGIGVFSSFSALLEQILCASGYS 86
Cdd:cd06174   158 AAALALLAAILLLLVVPDPPESARAKNEEASskSVLKLLKRVLKNPGLWLLLlAIFLVNLAYYSFSTLLPLFLLDLGGLS 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298  87 NEFSGLCGALFIVFGILGALLLGLYVDRtkHFTEATKIGLCLTSMTSVAFALVsqLQGQTLALAAICSLFGLFGFSVAPV 166
Cdd:cd06174   238 VAVAGLLLSLFGLAGALGSLLLGLLSDR--LIGRKPLLLIGLLLMALGLALLL--LAPSLLLLLLLLLLLGFGLGGLLPL 313

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1333886298 167 VMELAVECSFPVGEGASAGLIFVLGQAEGMLIMLLLTALTVRRTGPSF 214
Cdd:cd06174   314 SFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTG 361
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
10-193 1.90e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 42.65  E-value: 1.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298  10 AALACLLATVCLWESVPPTPPSTGAANSTSESFLRGLKLLIQnkAYVLLAVCFGGGIGVFSSFSALLEQILcasGYSNEF 89
Cdd:COG2814   170 NAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLL--LLLLAFLLGFGFFALFTYLPLYLQEVL---GLSASA 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298  90 SGLCGALFIVFGILGALLLGLYVDRTKHFTeATKIGLCLTSMTSVAFALVSQLqgqtLALAAICSLFGLFGFSVAPVVME 169
Cdd:COG2814   245 AGLLLALFGLGGVLGALLAGRLADRFGRRR-LLLIGLLLLALGLLLLALAGSL----WLLLLALFLLGFGFGLLFPLLQA 319

                         170       180
                  ....*....|....*....|....
gi 1333886298 170 LAVECSFPVGEGASAGLIFVLGQA 193
Cdd:COG2814   320 LVAELAPPEARGRASGLYNSAFFL 343
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
3-173 3.25e-04

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 42.17  E-value: 3.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298   3 LGIYIGPAALACLLATVCLWESVPPTPPSTGAAnstsesflrGLKLLIQNKAYVLLAVCFGGGIGVFSSFSALLEQILCA 82
Cdd:COG2807   174 LAVWALLALLALLLWLPLLRRRPAAAAAAPAAA---------SLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298  83 SGYSNEFSGLCGALFIVFGILGALLLGLYVDRTKHfteatKIGLCLTSMTSVAFALVSQLQGQTLALAAICSLFGLFGFS 162
Cdd:COG2807   245 AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGD-----RRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGG 319

                         170
                  ....*....|.
gi 1333886298 163 VAPVVMELAVE 173
Cdd:COG2807   320 LFPLALTLIGL 330
MFS_1 pfam07690
Major Facilitator Superfamily;
10-197 6.36e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 40.86  E-value: 6.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298  10 AALACLLATVCLWESVPPTPPSTGAANSTSESFLRGLKLLIQNKAYVLLAVCFGGGIGVFSSFSALLEQILCASGYSNEF 89
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALL 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298  90 SGLCGALFIVFGILGALLLGLYVDRTKHFTeATKIGLCLTSMTSVAFALVSqLQGQTLALAAICSLFGLFGFSVAPVVME 169
Cdd:pfam07690 237 AGLLLGLGGLLGAIGRLLLGRLSDRLGRRR-RLLLALLLLILAALGLLLLS-LTLSSLWLLLALLLLGFGFGLVFPALNA 314

                         170       180
                  ....*....|....*....|....*...
gi 1333886298 170 LAVECSFPVGEGASAGLIFVLGQAEGML 197
Cdd:pfam07690 315 LVSDLAPKEERGTASGLYNTAGSLGGAL 342
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 12-213 3.14e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 38.69  E-value: 3.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298  12 LACLLATVCLWESVPPTPPSTGaanstsesfLRGLKLLIQNKAYVLLAVCFGGGIGVFSSFSALLeqiLCASGYSNEFSG 91
Cdd:cd17477   159 LLALVPLLLTRRAAPEIEEAES---------ISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLY---GLRLGLSVAQAA 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298  92 LCGALFIVFGILGALLLGLYVDRTKHFteatKIGLCLTSMTSVAFALVSQLQGQTLALAAICSLFGLFGFSVAPVVMELA 171
Cdd:cd17477   227 LLLAAFVLGGLLLQWPLGWLADRFDRR----RVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALA 302

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1333886298 172 VEcSFPVGEGASAGLIFVLGQAEGMLIMLLLTALTVRRTGPS 213
Cdd:cd17477   303 GD-RLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPH 343
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
10-205 7.08e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 37.94  E-value: 7.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298  10 AALACLLATVCLWESVPPTPPSTGAANSTSesfLRGLKLLIQNKAYVLLAVCFGGGIGVFSSFSALLEQIL-CASGYSNE 88
Cdd:COG2223   165 LGILLLVVAVLAWLFLRDPPAGAAAAAKAS---LRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLvDQFGLSAA 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333886298  89 FSGLCGALFIVFGILGALLLGLYVDRTKhfteATKIGLCLTSMTSVAFALVSQLQGQ-TLALAAICSLFGLFGFSVAPVV 167
Cdd:COG2223   242 TAGLLAALFALLGALGRPLGGWLSDRIG----GRRVLLIVFALMALGLLLLALALGSlWLFLVLFLLLGLALGGGNGAVF 317

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1333886298 168 MELAVecSFPVGE-GASAGLIFVLGQAEGMLIMLLLTAL 205
Cdd:COG2223   318 ALVPD--IFPTKNaGAVYGLVGAAGGLGGFLGPLLFGAL 354
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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