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Conserved domains on  [gi|1317840782|ref|NP_001346195|]
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sex comb on midleg-like protein 4 isoform 4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SLED super family cl13561
SLED domain; The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding ...
 95-162 3.71e-23

SLED domain; The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding domain found in Scml2 which is a member of the Polycomb group of proteins involved in epigenetic gene silencing.


The actual alignment was detected with superfamily member pfam12140:

Pssm-ID: 463469  Cd Length: 112  Bit Score: 88.41  E-value: 3.71e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1317840782  95 TVCLYINKQADVGPYLERRKLQQLPERLGPERPATVLQQAVQACIDCAHQPRLVFSLVKQGYRGELVS 162
Cdd:pfam12140   1 TVCIYVNKNCFCGPHLDKKKIAELPDQFGPGPVSLVLKEVLQALIDCAYDPKQVLKLLKSGNGGREEI 68
RBR pfam17208
RNA binding Region;
1-60 6.85e-09

RNA binding Region;


:

Pssm-ID: 465382 [Multi-domain]  Cd Length: 56  Bit Score: 49.68  E-value: 6.85e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317840782   1 MQTQRVPGRkrGRPPLHSTrVQMAVHNLYSASAASVPaVTIPKKRGRKPRYKIKSPVLMT 60
Cdd:pfam17208   1 GQRGRKPGR--GKPPGSTS-APKKGSSPKNAPAKKEP-IKIPKKRGPKPGSKRKPRPVLS 56
 
Name Accession Description Interval E-value
SLED pfam12140
SLED domain; The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding ...
 95-162 3.71e-23

SLED domain; The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding domain found in Scml2 which is a member of the Polycomb group of proteins involved in epigenetic gene silencing.


Pssm-ID: 463469  Cd Length: 112  Bit Score: 88.41  E-value: 3.71e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1317840782  95 TVCLYINKQADVGPYLERRKLQQLPERLGPERPATVLQQAVQACIDCAHQPRLVFSLVKQGYRGELVS 162
Cdd:pfam12140   1 TVCIYVNKNCFCGPHLDKKKIAELPDQFGPGPVSLVLKEVLQALIDCAYDPKQVLKLLKSGNGGREEI 68
RBR pfam17208
RNA binding Region;
1-60 6.85e-09

RNA binding Region;


Pssm-ID: 465382 [Multi-domain]  Cd Length: 56  Bit Score: 49.68  E-value: 6.85e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317840782   1 MQTQRVPGRkrGRPPLHSTrVQMAVHNLYSASAASVPaVTIPKKRGRKPRYKIKSPVLMT 60
Cdd:pfam17208   1 GQRGRKPGR--GKPPGSTS-APKKGSSPKNAPAKKEP-IKIPKKRGPKPGSKRKPRPVLS 56
 
Name Accession Description Interval E-value
SLED pfam12140
SLED domain; The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding ...
 95-162 3.71e-23

SLED domain; The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding domain found in Scml2 which is a member of the Polycomb group of proteins involved in epigenetic gene silencing.


Pssm-ID: 463469  Cd Length: 112  Bit Score: 88.41  E-value: 3.71e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1317840782  95 TVCLYINKQADVGPYLERRKLQQLPERLGPERPATVLQQAVQACIDCAHQPRLVFSLVKQGYRGELVS 162
Cdd:pfam12140   1 TVCIYVNKNCFCGPHLDKKKIAELPDQFGPGPVSLVLKEVLQALIDCAYDPKQVLKLLKSGNGGREEI 68
RBR pfam17208
RNA binding Region;
1-60 6.85e-09

RNA binding Region;


Pssm-ID: 465382 [Multi-domain]  Cd Length: 56  Bit Score: 49.68  E-value: 6.85e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317840782   1 MQTQRVPGRkrGRPPLHSTrVQMAVHNLYSASAASVPaVTIPKKRGRKPRYKIKSPVLMT 60
Cdd:pfam17208   1 GQRGRKPGR--GKPPGSTS-APKKGSSPKNAPAKKEP-IKIPKKRGPKPGSKRKPRPVLS 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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