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Conserved domains on  [gi|1270530344|ref|NP_001344336|]
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uveal autoantigen with coiled-coil domains and ankyrin repeats isoform 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
34-271 1.25e-41

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 155.11  E-value: 1.25e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   34 NKYDDRLMKAAERGDVEKVSSILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKY 113
Cdd:COG0666     51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  114 GHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGA 193
Cdd:COG0666    131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1270530344  194 DVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNLLKTASENTNKGRELWRKG 271
Cdd:COG0666    211 DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 485-1308 1.47e-23

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 108.61  E-value: 1.47e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  485 ECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQtHFLALKEHLTNEAATGS-------HRIIEELREQLKDLKGK 557
Cdd:TIGR02168  176 ETERKLERTRENLDRLEDILNELERQLKSLERQAEKAE-RYKELKAELRELELALLvlrleelREELEELQEELKEAEEE 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  558 YEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERRGRRVVELEGQLKELGAKLalsvptEKF 637
Cdd:TIGR02168  255 LEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQL------EEL 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  638 ESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDL-ESVRAQHIRPEEHEQLRSR---LEQKSGELGKKVSELTLK 713
Cdd:TIGR02168  329 ESKLDELAEELAELEEKLEELKEELESLEAELEELEAELeELESRLEELEEQLETLRSKvaqLELQIASLNNEIERLEAR 408

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  714 NQTLQKDVEKLHADNKLLNQQVHSLtvEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEaerLLAENDK 793
Cdd:TIGR02168  409 LERLEDRRERLQQEIEELLKKLEEA--ELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQA---LDAAERE 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  794 LTKNVSRLEAVfvapEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRA-------------------LMSENSSLK 854
Cdd:TIGR02168  484 LAQLQARLDSL----ERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVdegyeaaieaalggrlqavVVENLNAAK 559

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  855 KTLSSQyvpaKTHEEVKAS---LNSTVEKTNRA-LLEAKKRFDDTSQEVSKLRDENEVLRRNLE---------------- 914
Cdd:TIGR02168  560 KAIAFL----KQNELGRVTflpLDSIKGTEIQGnDREILKNIEGFLGVAKDLVKFDPKLRKALSyllggvlvvddldnal 635

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  915 NVQNQMKADY--VSLEEH-------------SRRMSTVSQSlKEAQEANAAIladhRQGQEEIVSLHAEIKAQKKELDTI 979
Cdd:TIGR02168  636 ELAKKLRPGYriVTLDGDlvrpggvitggsaKTNSSILERR-REIEELEEKI----EELEEKIAELEKALAELRKELEEL 710

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  980 QECIKLKyapLARLEECERKFKAtekgLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREA 1059
Cdd:TIGR02168  711 EEELEQL---RKELEELSRQISA----LRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAE 783

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1060 ERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRS 1139
Cdd:TIGR02168  784 IEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEE 863

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1140 KQRCLEREQqtvSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKN 1219
Cdd:TIGR02168  864 LEELIEELE---SELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDN 940

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1220 LETR----EVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQ-------ACEEkvsAKDEKELLhlsieQEIRDQKERC 1288
Cdd:TIGR02168  941 LQERlseeYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKElgpvnlaAIEE---YEELKERY-----DFLTAQKEDL 1012

                          890       900
                   ....*....|....*....|
gi 1270530344 1289 DKSLTTIMELQQRIQESAKQ 1308
Cdd:TIGR02168 1013 TEAKETLEEAIEEIDREARE 1032
SMC_N super family cl47134
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 293-618 7.15e-03

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


The actual alignment was detected with superfamily member TIGR02169:

Pssm-ID: 481474 [Multi-domain]  Cd Length: 1164  Bit Score: 40.82  E-value: 7.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  293 REQREPHSFQDLEIENEDLREKLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIE 372
Cdd:TIGR02169  675 ELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIE 754

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  373 ALKNRFKYFESDHPgpgsypsnRKEDMLHKqgqmyttepqcaspgipphmhsrsmlrpLELSLPSqtsySENEILKKELE 452
Cdd:TIGR02169  755 NVKSELKELEARIE--------ELEEDLHK----------------------------LEEALND----LEARLSHSRIP 794

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  453 TLRTYYDSAKQDRLKFQNELAHKVAECKALALE---CERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQthflalk 529
Cdd:TIGR02169  795 EIQAELSKLEEEVSRIEARLREIEQKLNRLTLEkeyLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELE------- 867

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  530 ehltneaatgshRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELER 609
Cdd:TIGR02169  868 ------------EELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSE 935


                   ....*....
gi 1270530344  610 RGRRVVELE 618
Cdd:TIGR02169  936 IEDPKGEDE 944
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
34-271 1.25e-41

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 155.11  E-value: 1.25e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   34 NKYDDRLMKAAERGDVEKVSSILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKY 113
Cdd:COG0666     51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  114 GHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGA 193
Cdd:COG0666    131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1270530344  194 DVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNLLKTASENTNKGRELWRKG 271
Cdd:COG0666    211 DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 485-1308 1.47e-23

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 108.61  E-value: 1.47e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  485 ECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQtHFLALKEHLTNEAATGS-------HRIIEELREQLKDLKGK 557
Cdd:TIGR02168  176 ETERKLERTRENLDRLEDILNELERQLKSLERQAEKAE-RYKELKAELRELELALLvlrleelREELEELQEELKEAEEE 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  558 YEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERRGRRVVELEGQLKELGAKLalsvptEKF 637
Cdd:TIGR02168  255 LEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQL------EEL 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  638 ESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDL-ESVRAQHIRPEEHEQLRSR---LEQKSGELGKKVSELTLK 713
Cdd:TIGR02168  329 ESKLDELAEELAELEEKLEELKEELESLEAELEELEAELeELESRLEELEEQLETLRSKvaqLELQIASLNNEIERLEAR 408

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  714 NQTLQKDVEKLHADNKLLNQQVHSLtvEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEaerLLAENDK 793
Cdd:TIGR02168  409 LERLEDRRERLQQEIEELLKKLEEA--ELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQA---LDAAERE 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  794 LTKNVSRLEAVfvapEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRA-------------------LMSENSSLK 854
Cdd:TIGR02168  484 LAQLQARLDSL----ERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVdegyeaaieaalggrlqavVVENLNAAK 559

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  855 KTLSSQyvpaKTHEEVKAS---LNSTVEKTNRA-LLEAKKRFDDTSQEVSKLRDENEVLRRNLE---------------- 914
Cdd:TIGR02168  560 KAIAFL----KQNELGRVTflpLDSIKGTEIQGnDREILKNIEGFLGVAKDLVKFDPKLRKALSyllggvlvvddldnal 635

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  915 NVQNQMKADY--VSLEEH-------------SRRMSTVSQSlKEAQEANAAIladhRQGQEEIVSLHAEIKAQKKELDTI 979
Cdd:TIGR02168  636 ELAKKLRPGYriVTLDGDlvrpggvitggsaKTNSSILERR-REIEELEEKI----EELEEKIAELEKALAELRKELEEL 710

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  980 QECIKLKyapLARLEECERKFKAtekgLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREA 1059
Cdd:TIGR02168  711 EEELEQL---RKELEELSRQISA----LRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAE 783

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1060 ERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRS 1139
Cdd:TIGR02168  784 IEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEE 863

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1140 KQRCLEREQqtvSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKN 1219
Cdd:TIGR02168  864 LEELIEELE---SELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDN 940

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1220 LETR----EVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQ-------ACEEkvsAKDEKELLhlsieQEIRDQKERC 1288
Cdd:TIGR02168  941 LQERlseeYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKElgpvnlaAIEE---YEELKERY-----DFLTAQKEDL 1012

                          890       900
                   ....*....|....*....|
gi 1270530344 1289 DKSLTTIMELQQRIQESAKQ 1308
Cdd:TIGR02168 1013 TEAKETLEEAIEEIDREARE 1032
Ank_2 pfam12796
Ankyrin repeats (3 copies);
107-199 2.67e-19

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 84.01  E-value: 2.67e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  107 LHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHgASVNAKDiDGRTPLVLATQMCRPTICQ 186
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1270530344  187 LLIDRGADVNSRD 199
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 50-218 9.55e-19

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 91.24  E-value: 9.55e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   50 EKVSSILAKKGVHPGKLDVEGRSAFHV-VASKG-NLECLNAILTHGIDVATRDSAGRNALHLAAKYGH--ALCLQKLLQY 125
Cdd:PHA03095   132 PKVIRLLLRKGADVNALDLYGMTPLAVlLKSRNaNVELLRLLIDAGADVYAVDDRFRSLLHHHLQSFKprARIVRELIRA 211

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  126 NCPTEHVDLQGRTALHDAAM-ADCPSS-IQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNR 203
Cdd:PHA03095   212 GCDPAATDMLGNTPLHSMATgSSCKRSlVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGN 291

                          170
                   ....*....|....*
gi 1270530344  204 TALMLGCEYGCRDAV 218
Cdd:PHA03095   292 TPLSLMVRNNNGRAV 306
PTZ00121 PTZ00121
MAEBL; Provisional
 458-1281 2.75e-18

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 91.74  E-value: 2.75e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  458 YDSAKQDRLKFQNELAHKVAEcKALALECERVKEDS--DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTNE 535
Cdd:PTZ00121  1081 FDAKEDNRADEATEEAFGKAE-EAKKTETGKAEEARkaEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIARK 1159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  536 AATGshRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKR--DEGRLVEENKRLQKECGTCEVELERRGRR 613
Cdd:PTZ00121  1160 AEDA--RKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARkaEEERKAEEARKAEDAKKAEAVKKAEEAKK 1237

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  614 VVELEGQLKELGAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYEsaqgeirQLKRDLESVRAQHIRPEEHEQLR 693
Cdd:PTZ00121  1238 DAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAE-------EKKKADEAKKAEEKKKADEAKKK 1310

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  694 SRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQqvhsltvEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEA 773
Cdd:PTZ00121  1311 AEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKA-------EAEAAADEAEAAEEKAEAAEKKKEEAKKKADAA 1383

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  774 TQRYTEKKQ--EAERLLAENDKLTKNVSRLEAVFVAPEKHEKElmglksniAELKKQLSELNKKcGEGQEKIRALMSENS 851
Cdd:PTZ00121  1384 KKKAEEKKKadEAKKKAEEDKKKADELKKAAAAKKKADEAKKK--------AEEKKKADEAKKK-AEEAKKADEAKKKAE 1454

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  852 SLKKtlsSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRR--NLENVQNQMKADYVSLEE 929
Cdd:PTZ00121  1455 EAKK---AEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKadEAKKAEEAKKADEAKKAE 1531

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  930 HSRRMSTVSQSlKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKE 1009
Cdd:PTZ00121  1532 EAKKADEAKKA-EEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAE 1610

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1010 QLsEQTHKCRQRDEEVKKGKQEnerlRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSERE 1089
Cdd:PTZ00121  1611 EA-KKAEEAKIKAEELKKAEEE----KKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEE 1685

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1090 ---KLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKS---LNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKN 1163
Cdd:PTZ00121  1686 dekKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAeeeNKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKE 1765

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1164 SSVTLAEHLKLKEA-LEKEVGIMKASLREKEEESQKKTKEVSKL----------------QTEVQTTKQAL--KNLETRE 1224
Cdd:PTZ00121  1766 EEKKAEEIRKEKEAvIEEELDEEDEKRRMEVDKKIKDIFDNFANiieggkegnlvindskEMEDSAIKEVAdsKNMQLEE 1845

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1270530344 1225 VVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEI 1281
Cdd:PTZ00121  1846 ADAFEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEIEEADEIEKIDKDDIEREI 1902
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 487-1314 2.09e-13

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 75.54  E-value: 2.09e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  487 ERVKEDSDEQIKQLEDALKD-----------VQKRMYESEGKVKQMQTHFLALKEHLTNEAATGshriiEELREQLKDLK 555
Cdd:pfam15921   77 ERVLEEYSHQVKDLQRRLNEsnelhekqkfyLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQ-----EDLRNQLQNTV 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  556 GKYEGA-SAEVGKLRSQIKQSEMLVGEFKRDEGRLveenkrlqKECGTCEVELER-RGRRVVELEgqlkelgaklalSVP 633
Cdd:pfam15921  152 HELEAAkCLKEDMLEDSNTQIEQLRKMMLSHEGVL--------QEIRSILVDFEEaSGKKIYEHD------------SMS 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  634 TEKFESMKSSLSndinekvKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPEEH--EQLRSRLEQKSGELGKKVSELT 711
Cdd:pfam15921  212 TMHFRSLGSAIS-------KILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELllQQHQDRIEQLISEHEVEITGLT 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  712 LKNQTLQKDVEKLHADNKLLNQQVHSLTV-------EMKTRYVPLRVS-EEMKKSHDVNVEDLNKKLSEATQRYTEKKQE 783
Cdd:pfam15921  285 EKASSARSQANSIQSQLEIIQEQARNQNSmymrqlsDLESTVSQLRSElREAKRMYEDKIEELEKQLVLANSELTEARTE 364

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  784 AERLLAENDKLTKNVSRLEAVFvapEKHEKELmglksniaELKKqlsELNKKCGEGQEKIRALMSEnssLKKTLSSQYVP 863
Cdd:pfam15921  365 RDQFSQESGNLDDQLQKLLADL---HKREKEL--------SLEK---EQNKRLWDRDTGNSITIDH---LRRELDDRNME 427

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  864 AKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKE 943
Cdd:pfam15921  428 VQRLEALLKAMKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQE 507

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  944 AQEANAAILAdhrqgqeEIVSLHAEIKAQKKELDTIQ-ECIKLKYAPlarlEECER-KFKATEKG-LKEQLSEQTHKCRQ 1020
Cdd:pfam15921  508 KERAIEATNA-------EITKLRSRVDLKLQELQHLKnEGDHLRNVQ----TECEAlKLQMAEKDkVIEILRQQIENMTQ 576

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1021 RdeeVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLS--------------QKYSDVKS 1086
Cdd:pfam15921  577 L---VGQHGRTAGAMQVEKAQLEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLElekvklvnagserlRAVKDIKQ 653

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1087 EREKLVEEKAKQASEIlaaQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSV 1166
Cdd:pfam15921  654 ERDQLLNEVKTSRNEL---NSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAM 730

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1167 TLAEHLKLK----EALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTkqalknletreVVDMSKYKATKNDLETQI 1242
Cdd:pfam15921  731 GMQKQITAKrgqiDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTV-----------ATEKNKMAGELEVLRSQE 799

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1270530344 1243 SNLNDKLASLNRKYDQACEEKVSAKD-----EKELLHLSIEQEIrDQKERCDKSLTTIMELQQRIQESAKQIEAKDN 1314
Cdd:pfam15921  800 RRLKEKVANMEVALDKASLQFAECQDiiqrqEQESVRLKLQHTL-DVKELQGPGYTSNSSMKPRLLQPASFTRTHSN 875
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1066-1409 2.12e-12

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 72.28  E-value: 2.12e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1066 KADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQpvpLEQVEALKKSLNGTIEQLKEELRSKQRCLE 1145
Cdd:COG1196    233 KLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEEL---ELELEEAQAEEYELLAELARLEQDIARLEE 309

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1146 REQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEE---ESQKKTKEVSKLQTEVQTTKQALKNLET 1222
Cdd:COG1196    310 RRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAelaEAEEALLEAEAELAEAEEELEELAEELL 389

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1223 REVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERcdksLTTIMELQQRI 1302
Cdd:COG1196    390 EALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAEL----EEEEEALLELL 465

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1303 QESAKQIEAKDNKITELLNDVERLKQALNGLSQLTyssgspTKRQSQLVDTLQQRVRDLQQQLADADRQHQEVIAIYRTH 1382
Cdd:COG1196    466 AELLEEAALLEAALAELLEELAEAAARLLLLLEAE------ADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAA 539

                          330       340
                   ....*....|....*....|....*..
gi 1270530344 1383 LLSAAQGHMDEDVQAALLQIIQMRQGL 1409
Cdd:COG1196    540 LEAALAAALQNIVVEDDEVAAAAIEYL 566
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 22-236 8.69e-08

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 57.01  E-value: 8.69e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   22 PTAVASTQSAEWNKYDDRLMKAAERGDVEKVSsilaKKGVHPGKLDVE-----GRSAFHVVASKGNLECLNAIL-THGID 95
Cdd:TIGR00870    3 PLDIVPAEESPLSDEEKAFLPAAERGDLASVY----RDLEEPKKLNINcpdrlGRSALFVAAIENENLELTELLlNLSCR 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   96 VATrdsaGRNALHLAAKYGHA---LCLQKLLQ---YNCPTEHVDLQ-------GRTALHDAAMADCPSSIQLLCDHGASV 162
Cdd:TIGR00870   79 GAV----GDTLLHAISLEYVDaveAILLHLLAafrKSGPLELANDQytseftpGITALHLAAHRQNYEIVKLLLERGASV 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  163 NAK----------DID----GRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALML-------GCEY--------- 212
Cdd:TIGR00870  155 PARacgdffvksqGVDsfyhGESPLNAAACLGSPSIVALLSEDPADILTADSLGNTLLHLlvmenefKAEYeelscqmyn 234

                          250       260       270
                   ....*....|....*....|....*....|..
gi 1270530344  213 -------GCRDAVEV-LVKNGADLTLLDALGH 236
Cdd:TIGR00870  235 falslldKLRDSKELeVILNHQGLTPLKLAAK 266
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 78-206 4.82e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 54.25  E-value: 4.82e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   78 ASKGNLECLNAILT-HGIDVATRDSAGRNALHLAAKYGHALCLQKLLqyNCPTEHVDL-------QGRTALHDAAMADCP 149
Cdd:cd22192     25 AKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLM--EAAPELVNEpmtsdlyQGETALHIAVVNQNL 102

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1270530344  150 SSIQLLCDHGASVNA---------KDID-----GRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTAL 206
Cdd:cd22192    103 NLVRELIARGADVVSpratgtffrPGPKnliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 293-618 7.15e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.82  E-value: 7.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  293 REQREPHSFQDLEIENEDLREKLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIE 372
Cdd:TIGR02169  675 ELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIE 754

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  373 ALKNRFKYFESDHPgpgsypsnRKEDMLHKqgqmyttepqcaspgipphmhsrsmlrpLELSLPSqtsySENEILKKELE 452
Cdd:TIGR02169  755 NVKSELKELEARIE--------ELEEDLHK----------------------------LEEALND----LEARLSHSRIP 794

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  453 TLRTYYDSAKQDRLKFQNELAHKVAECKALALE---CERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQthflalk 529
Cdd:TIGR02169  795 EIQAELSKLEEEVSRIEARLREIEQKLNRLTLEkeyLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELE------- 867

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  530 ehltneaatgshRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELER 609
Cdd:TIGR02169  868 ------------EELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSE 935


                   ....*....
gi 1270530344  610 RGRRVVELE 618
Cdd:TIGR02169  936 IEDPKGEDE 944
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
34-271 1.25e-41

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 155.11  E-value: 1.25e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   34 NKYDDRLMKAAERGDVEKVSSILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKY 113
Cdd:COG0666     51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  114 GHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGA 193
Cdd:COG0666    131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1270530344  194 DVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNLLKTASENTNKGRELWRKG 271
Cdd:COG0666    211 DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
31-263 4.81e-40

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 150.49  E-value: 4.81e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   31 AEWNKYDDRLMKAAERGDVEKVSSILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLA 110
Cdd:COG0666     15 LLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAA 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  111 AKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLID 190
Cdd:COG0666     95 ARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLE 174

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1270530344  191 RGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNLLKTASENTNK 263
Cdd:COG0666    175 AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNA 247
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
55-254 7.59e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 123.91  E-value: 7.59e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   55 ILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDL 134
Cdd:COG0666      6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  135 QGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGC 214
Cdd:COG0666     86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGN 165

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1270530344  215 RDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNLL 254
Cdd:COG0666    166 LEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 485-1308 1.47e-23

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 108.61  E-value: 1.47e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  485 ECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQtHFLALKEHLTNEAATGS-------HRIIEELREQLKDLKGK 557
Cdd:TIGR02168  176 ETERKLERTRENLDRLEDILNELERQLKSLERQAEKAE-RYKELKAELRELELALLvlrleelREELEELQEELKEAEEE 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  558 YEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERRGRRVVELEGQLKELGAKLalsvptEKF 637
Cdd:TIGR02168  255 LEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQL------EEL 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  638 ESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDL-ESVRAQHIRPEEHEQLRSR---LEQKSGELGKKVSELTLK 713
Cdd:TIGR02168  329 ESKLDELAEELAELEEKLEELKEELESLEAELEELEAELeELESRLEELEEQLETLRSKvaqLELQIASLNNEIERLEAR 408

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  714 NQTLQKDVEKLHADNKLLNQQVHSLtvEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEaerLLAENDK 793
Cdd:TIGR02168  409 LERLEDRRERLQQEIEELLKKLEEA--ELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQA---LDAAERE 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  794 LTKNVSRLEAVfvapEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRA-------------------LMSENSSLK 854
Cdd:TIGR02168  484 LAQLQARLDSL----ERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVdegyeaaieaalggrlqavVVENLNAAK 559

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  855 KTLSSQyvpaKTHEEVKAS---LNSTVEKTNRA-LLEAKKRFDDTSQEVSKLRDENEVLRRNLE---------------- 914
Cdd:TIGR02168  560 KAIAFL----KQNELGRVTflpLDSIKGTEIQGnDREILKNIEGFLGVAKDLVKFDPKLRKALSyllggvlvvddldnal 635

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  915 NVQNQMKADY--VSLEEH-------------SRRMSTVSQSlKEAQEANAAIladhRQGQEEIVSLHAEIKAQKKELDTI 979
Cdd:TIGR02168  636 ELAKKLRPGYriVTLDGDlvrpggvitggsaKTNSSILERR-REIEELEEKI----EELEEKIAELEKALAELRKELEEL 710

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  980 QECIKLKyapLARLEECERKFKAtekgLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREA 1059
Cdd:TIGR02168  711 EEELEQL---RKELEELSRQISA----LRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAE 783

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1060 ERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRS 1139
Cdd:TIGR02168  784 IEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEE 863

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1140 KQRCLEREQqtvSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKN 1219
Cdd:TIGR02168  864 LEELIEELE---SELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDN 940

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1220 LETR----EVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQ-------ACEEkvsAKDEKELLhlsieQEIRDQKERC 1288
Cdd:TIGR02168  941 LQERlseeYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKElgpvnlaAIEE---YEELKERY-----DFLTAQKEDL 1012

                          890       900
                   ....*....|....*....|
gi 1270530344 1289 DKSLTTIMELQQRIQESAKQ 1308
Cdd:TIGR02168 1013 TEAKETLEEAIEEIDREARE 1032
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
40-206 1.29e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 99.64  E-value: 1.29e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   40 LMKAAERGDVEKVSsILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCL 119
Cdd:COG0666    124 LHLAAYNGNLEIVK-LLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIV 202

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  120 QKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRD 199
Cdd:COG0666    203 KLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282


                   ....*..
gi 1270530344  200 KQNRTAL 206
Cdd:COG0666    283 LDLLTLL 289
Ank_2 pfam12796
Ankyrin repeats (3 copies);
107-199 2.67e-19

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 84.01  E-value: 2.67e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  107 LHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHgASVNAKDiDGRTPLVLATQMCRPTICQ 186
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1270530344  187 LLIDRGADVNSRD 199
Cdd:pfam12796   79 LLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
86-254 2.69e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 90.01  E-value: 2.69e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   86 LNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAK 165
Cdd:COG0666      4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  166 DIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIG 245
Cdd:COG0666     84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAAN 163


                   ....*....
gi 1270530344  246 DNLDILNLL 254
Cdd:COG0666    164 GNLEIVKLL 172
PHA03095 PHA03095
ankyrin-like protein; Provisional
 50-218 9.55e-19

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 91.24  E-value: 9.55e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   50 EKVSSILAKKGVHPGKLDVEGRSAFHV-VASKG-NLECLNAILTHGIDVATRDSAGRNALHLAAKYGH--ALCLQKLLQY 125
Cdd:PHA03095   132 PKVIRLLLRKGADVNALDLYGMTPLAVlLKSRNaNVELLRLLIDAGADVYAVDDRFRSLLHHHLQSFKprARIVRELIRA 211

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  126 NCPTEHVDLQGRTALHDAAM-ADCPSS-IQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNR 203
Cdd:PHA03095   212 GCDPAATDMLGNTPLHSMATgSSCKRSlVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGN 291

                          170
                   ....*....|....*
gi 1270530344  204 TALMLGCEYGCRDAV 218
Cdd:PHA03095   292 TPLSLMVRNNNGRAV 306
Ank_2 pfam12796
Ankyrin repeats (3 copies);
74-166 1.85e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 81.70  E-value: 1.85e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   74 FHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTehVDLQGRTALHDAAMADCPSSIQ 153
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN--LKDNGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1270530344  154 LLCDHGASVNAKD 166
Cdd:pfam12796   79 LLLEKGADINVKD 91
PTZ00121 PTZ00121
MAEBL; Provisional
 458-1281 2.75e-18

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 91.74  E-value: 2.75e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  458 YDSAKQDRLKFQNELAHKVAEcKALALECERVKEDS--DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTNE 535
Cdd:PTZ00121  1081 FDAKEDNRADEATEEAFGKAE-EAKKTETGKAEEARkaEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIARK 1159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  536 AATGshRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKR--DEGRLVEENKRLQKECGTCEVELERRGRR 613
Cdd:PTZ00121  1160 AEDA--RKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARkaEEERKAEEARKAEDAKKAEAVKKAEEAKK 1237

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  614 VVELEGQLKELGAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYEsaqgeirQLKRDLESVRAQHIRPEEHEQLR 693
Cdd:PTZ00121  1238 DAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAE-------EKKKADEAKKAEEKKKADEAKKK 1310

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  694 SRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQqvhsltvEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEA 773
Cdd:PTZ00121  1311 AEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKA-------EAEAAADEAEAAEEKAEAAEKKKEEAKKKADAA 1383

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  774 TQRYTEKKQ--EAERLLAENDKLTKNVSRLEAVFVAPEKHEKElmglksniAELKKQLSELNKKcGEGQEKIRALMSENS 851
Cdd:PTZ00121  1384 KKKAEEKKKadEAKKKAEEDKKKADELKKAAAAKKKADEAKKK--------AEEKKKADEAKKK-AEEAKKADEAKKKAE 1454

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  852 SLKKtlsSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRR--NLENVQNQMKADYVSLEE 929
Cdd:PTZ00121  1455 EAKK---AEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKadEAKKAEEAKKADEAKKAE 1531

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  930 HSRRMSTVSQSlKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKE 1009
Cdd:PTZ00121  1532 EAKKADEAKKA-EEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAE 1610

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1010 QLsEQTHKCRQRDEEVKKGKQEnerlRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSERE 1089
Cdd:PTZ00121  1611 EA-KKAEEAKIKAEELKKAEEE----KKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEE 1685

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1090 ---KLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKS---LNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKN 1163
Cdd:PTZ00121  1686 dekKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAeeeNKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKE 1765

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1164 SSVTLAEHLKLKEA-LEKEVGIMKASLREKEEESQKKTKEVSKL----------------QTEVQTTKQAL--KNLETRE 1224
Cdd:PTZ00121  1766 EEKKAEEIRKEKEAvIEEELDEEDEKRRMEVDKKIKDIFDNFANiieggkegnlvindskEMEDSAIKEVAdsKNMQLEE 1845

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1270530344 1225 VVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEI 1281
Cdd:PTZ00121  1846 ADAFEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEIEEADEIEKIDKDDIEREI 1902
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
635-1221 5.89e-18

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 90.12  E-value: 5.89e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  635 EKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPEEHEQLRSRLEQKSGELGKKVSELTLKN 714
Cdd:PRK03918   182 EKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKI 261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  715 QTLQKDVEKLHADNKLLNQQVHSLtvemktryvplrvsEEMKKshdvnVEDLNKKLSEATQRYTEKKQEAERLLAendKL 794
Cdd:PRK03918   262 RELEERIEELKKEIEELEEKVKEL--------------KELKE-----KAEEYIKLSEFYEEYLDELREIEKRLS---RL 319

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  795 TKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELnKKCGEGQEKIRALMSENSSLKKTLSsqyvpaktheevkasl 874
Cdd:PRK03918   320 EEEINGIEERIKELEEKEERLEELKKKLKELEKRLEEL-EERHELYEEAKAKKEELERLKKRLT---------------- 382

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  875 NSTVEKTNRALLEAKKRFDDTSQEVSKLRDEnevlRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEAN-----A 949
Cdd:PRK03918   383 GLTPEKLEKELEELEKAKEEIEEEISKITAR----IGELKKEIKELKKAIEELKKAKGKCPVCGRELTEEHRKElleeyT 458

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  950 AILADHRQGQEEIVSLHAEIKAQKKELDTIQEciklKYAPLARLEECERKFKATEKGLKEQLSEqthKCRQRDEEVKKGK 1029
Cdd:PRK03918   459 AELKRIEKELKEIEEKERKLRKELRELEKVLK----KESELIKLKELAEQLKELEEKLKKYNLE---ELEKKAEEYEKLK 531

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1030 QENERLRADLAALQKELQDRNALAEEAREAERalsgKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLL 1109
Cdd:PRK03918   532 EKLIKLKGEIKSLKKELEKLEELKKKLAELEK----KLDELEEELAELLKELEELGFESVEELEERLKELEPFYNEYLEL 607

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1110 QKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQqllenQKNSSVTLAEHLKLKEALEKEVGIMKASL 1189
Cdd:PRK03918   608 KDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELE-----KKYSEEEYEELREEYLELSRELAGLRAEL 682

                          570       580       590
                   ....*....|....*....|....*....|..
gi 1270530344 1190 REKEEESQKKTKEVSKLQTEVQTTKQALKNLE 1221
Cdd:PRK03918   683 EELEKRREEIKKTLEKLKEELEEREKAKKELE 714
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 543-1365 6.74e-17

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 87.05  E-value: 6.74e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  543 IIEELREQLKDLKG------KYEGASAEVGKLRSQIKQSEMLVGEfkRDEGRLVEENKRLQKECGTCEVELERRGRRVVE 616
Cdd:TIGR02169  192 IIDEKRQQLERLRRerekaeRYQALLKEKREYEGYELLKEKEALE--RQKEAIERQLASLEEELEKLTEEISELEKRLEE 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  617 LEGQLKELGAKLalsvptekfesmKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPEEheqLRSRL 696
Cdd:TIGR02169  270 IEQLLEELNKKI------------KDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEA---EIDKL 334

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  697 EQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRvseemkkshdvnveDLNKKLSEATQR 776
Cdd:TIGR02169  335 LAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELK--------------DYREKLEKLKRE 400

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  777 YTEKKQEAERLLAENDKLTKNVSRLEAvfvapekhekELMGLKSNIAELKKQLSELnkkcgegQEKIRALMSENSSLKKT 856
Cdd:TIGR02169  401 INELKRELDRLQEELQRLSEELADLNA----------AIAGIEAKINELEEEKEDK-------ALEIKKQEWKLEQLAAD 463

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  857 LSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMkADYVSLEEH------ 930
Cdd:TIGR02169  464 LSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTV-AQLGSVGERyataie 542

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  931 ---SRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHaEIKAQKKELDTIQECIKLKYAplARLEECERKFKATEK-- 1005
Cdd:TIGR02169  543 vaaGNRLNNVVVEDDAVAKEAIELLKRRKAGRATFLPLN-KMRDERRDLSILSEDGVIGFA--VDLVEFDPKYEPAFKyv 619

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1006 -----------------------GLKEQLSEQT-------HKCRQRDEEVKKGKQENERLRADLAALQKELQDrnalaee 1055
Cdd:TIGR02169  620 fgdtlvvedieaarrlmgkyrmvTLEGELFEKSgamtggsRAPRGGILFSRSEPAELQRLRERLEGLKRELSS------- 692

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1056 AREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKE 1135
Cdd:TIGR02169  693 LQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEE 772

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1136 ElrskqrcLEREQQTVSQLQQLLENQKNSSVTlaehlKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQ 1215
Cdd:TIGR02169  773 D-------LHKLEEALNDLEARLSHSRIPEIQ-----AELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQE 840

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1216 ALKNLETRevvdmskykatKNDLETQISNLNDKLASLNRKYDQAceEKVSAKDEKELLHLSIEQEIRDQKERcdksltti 1295
Cdd:TIGR02169  841 QRIDLKEQ-----------IKSIEKEIENLNGKKEELEEELEEL--EAALRDLESRLGDLKKERDELEAQLR-------- 899

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1296 mELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTySSGSPTKRQSQLVDTLQQRVRDLQQQL 1365
Cdd:TIGR02169  900 -ELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPK-GEDEEIPEEELSLEDVQAELQRVEEEI 967
Ank_2 pfam12796
Ankyrin repeats (3 copies);
140-232 9.54e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 76.69  E-value: 9.54e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  140 LHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRgADVNSRDkQNRTALMLGCEYGCRDAVE 219
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1270530344  220 VLVKNGADLTLLD 232
Cdd:pfam12796   79 LLLEKGADINVKD 91
PTZ00121 PTZ00121
MAEBL; Provisional
 631-1328 1.04e-16

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 86.73  E-value: 1.04e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  631 SVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQ-----LKRDLESVRAQHIRPEEH----EQLRSRLEQKSG 701
Cdd:PTZ00121  1075 SYKDFDFDAKEDNRADEATEEAFGKAEEAKKTETGKAEEARkaeeaKKKAEDARKAEEARKAEDarkaEEARKAEDAKRV 1154

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  702 ELGKKVSELTLKNQTLQ-KDVEKLHADNKL--------LNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSE 772
Cdd:PTZ00121  1155 EIARKAEDARKAEEARKaEDAKKAEAARKAeevrkaeeLRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEE 1234

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  773 ATQRYTE-KKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKkcgeGQEKIRAlmsenS 851
Cdd:PTZ00121  1235 AKKDAEEaKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKK----AEEKKKA-----D 1305

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  852 SLKKtlssqyvpaKTHEEVKA-SLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEH 930
Cdd:PTZ00121  1306 EAKK---------KAEEAKKAdEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEA 1376

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  931 SRRMSTVSQSLKEAQEANaailadhrqgqeeivslhaeiKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQ 1010
Cdd:PTZ00121  1377 KKKADAAKKKAEEKKKAD---------------------EAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADE 1435

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1011 LSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREK 1090
Cdd:PTZ00121  1436 AKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEA 1515

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1091 LVEEKAKQASEILAAQNllQKQPVPLEQVEALKKSlngtieqlkEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAE 1170
Cdd:PTZ00121  1516 KKAEEAKKADEAKKAEE--AKKADEAKKAEEKKKA---------DELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAE 1584

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1171 HLKLKE--------ALEKEVGIMKASLREKEEESQKKTKEVSKlQTEVQTTKQALKNLETREVVDMSKYKATKNDLETQI 1242
Cdd:PTZ00121  1585 EAKKAEearieevmKLYEEEKKMKAEEAKKAEEAKIKAEELKK-AEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKA 1663

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1243 SNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEqeirdQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLND 1322
Cdd:PTZ00121  1664 AEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAE-----EAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKE 1738


                   ....*.
gi 1270530344 1323 VERLKQ 1328
Cdd:PTZ00121  1739 AEEDKK 1744
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 649-1366 1.21e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 86.26  E-value: 1.21e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  649 NEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQH----------------------IRPEEHEQLRSRLEQKSGELGKK 706
Cdd:TIGR02168  175 KETERKLERTRENLDRLEDILNELERQLKSLERQAekaerykelkaelrelelallvLRLEELREELEELQEELKEAEEE 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  707 VSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAER 786
Cdd:TIGR02168  255 LEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDE 334

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  787 LLAENDKLTKNVSRLEAVFVAP----EKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSS--- 859
Cdd:TIGR02168  335 LAEELAELEEKLEELKEELESLeaelEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERled 414

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  860 ---------QYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNL---ENVQNQMKADYVSL 927
Cdd:TIGR02168  415 rrerlqqeiEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALdaaERELAQLQARLDSL 494

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  928 EEHSRRMSTVSQSLKE--------------------------------------------AQEANAAI--LADHRQGQ-- 959
Cdd:TIGR02168  495 ERLQENLEGFSEGVKAllknqsglsgilgvlselisvdegyeaaieaalggrlqavvvenLNAAKKAIafLKQNELGRvt 574

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  960 --EEIVSLHAEIKAQKKELDTIQECIKlkyAPLARLEECERKFKATEKGL------KEQLSEQTHKCRQRDEEVKKGKQE 1031
Cdd:TIGR02168  575 flPLDSIKGTEIQGNDREILKNIEGFL---GVAKDLVKFDPKLRKALSYLlggvlvVDDLDNALELAKKLRPGYRIVTLD 651

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1032 NERLRADLAALQKE------LQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAA 1105
Cdd:TIGR02168  652 GDLVRPGGVITGGSaktnssILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISAL 731

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1106 QNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQ-------QTVSQLQQLLENQKNSSVTLAEHLKlkeAL 1178
Cdd:TIGR02168  732 RKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEeelaeaeAEIEELEAQIEQLKEELKALREALD---EL 808

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1179 EKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLEtrevVDMSKYKATKNDLETQISNLNDKLASLNRKYDQ 1258
Cdd:TIGR02168  809 RAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELS----EDIESLAAEIEELEELIEELESELEALLNERAS 884

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1259 ACEEKVSAKDEKELLhlsiEQEIRDQKERcdkslttIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTY 1338
Cdd:TIGR02168  885 LEEALALLRSELEEL----SEELRELESK-------RSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTL 953

                          810       820
                   ....*....|....*....|....*....
gi 1270530344 1339 SSGSPTKRQSQL-VDTLQQRVRDLQQQLA 1366
Cdd:TIGR02168  954 EEAEALENKIEDdEEEARRRLKRLENKIK 982
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 771-1374 1.60e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 85.88  E-value: 1.60e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  771 SEATQRYTEKKQEAERLLAE--NDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMS 848
Cdd:TIGR02168  209 AEKAERYKELKAELRELELAllVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQK 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  849 ENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLE 928
Cdd:TIGR02168  289 ELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELE 368

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  929 EHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIK--LKYAPLARLEECERKFKATEKG 1006
Cdd:TIGR02168  369 ELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEelLKKLEEAELKELQAELEELEEE 448

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1007 LKEQLSEQthkcRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKS 1086
Cdd:TIGR02168  449 LEELQEEL----ERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGV 524

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1087 EREKL-VEEKAKQASEILAAQNLLQ----KQPVPLEQVEALKKSLNG------------------TIEQLKEELRSKQRC 1143
Cdd:TIGR02168  525 LSELIsVDEGYEAAIEAALGGRLQAvvveNLNAAKKAIAFLKQNELGrvtflpldsikgteiqgnDREILKNIEGFLGVA 604

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1144 LEREQQT----------------VSQLQQLLENQKNSS-----VTLAEHL------KLKEALEKEVGIM--KASLREKEE 1194
Cdd:TIGR02168  605 KDLVKFDpklrkalsyllggvlvVDDLDNALELAKKLRpgyriVTLDGDLvrpggvITGGSAKTNSSILerRREIEELEE 684

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1195 ESQKKTKEVSKLQTEVQTTKQALKNLETrevvDMSKYKATKNDLETQISNLNDKLASLNRK-------YDQACEEKVSAK 1267
Cdd:TIGR02168  685 KIEELEEKIAELEKALAELRKELEELEE----ELEQLRKELEELSRQISALRKDLARLEAEveqleerIAQLSKELTELE 760

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1268 DEKELLHLSIEQEIRDQKERCDKslttIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQ 1347
Cdd:TIGR02168  761 AEIEELEERLEEAEEELAEAEAE----IEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAAT 836

                          650       660
                   ....*....|....*....|....*..
gi 1270530344 1348 SQLVDTLQQRVRDLQQQLADADRQHQE 1374
Cdd:TIGR02168  837 ERRLEDLEEQIEELSEDIESLAAEIEE 863
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 485-1298 6.37e-16

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 83.58  E-value: 6.37e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  485 ECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTH------FLALKEHLTNEAATGSHRIIEELREQLKDLKGKY 558
Cdd:TIGR02169  167 EFDRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRRErekaerYQALLKEKREYEGYELLKEKEALERQKEAIERQL 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  559 EGASAEVGKLRSQIKQSEMLVGEF--------KRDEGRLVEENKRLQKECGTCEVELERRGRRVVELEGQLKELGAKLA- 629
Cdd:TIGR02169  247 ASLEEELEKLTEEISELEKRLEEIeqlleelnKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAk 326

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  630 LSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRP-EEHEQLRSRLEQksgeLGKKVS 708
Cdd:TIGR02169  327 LEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETrDELKDYREKLEK----LKREIN 402

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  709 ELTLKNQTLQKDVEKLHADNKLLNQQVHSLtvemktryvplrvsEEMKKSHDVNVEDLNKKLSEATQrytekkqEAERLL 788
Cdd:TIGR02169  403 ELKRELDRLQEELQRLSEELADLNAAIAGI--------------EAKINELEEEKEDKALEIKKQEW-------KLEQLA 461

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  789 AENDKLTKNVSRLEAVFvapEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSS------QYV 862
Cdd:TIGR02169  462 ADLSKYEQELYDLKEEY---DRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAQlgsvgeRYA 538

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  863 PAKtheEVKAS--LNSTVEKTNR------ALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRrm 934
Cdd:TIGR02169  539 TAI---EVAAGnrLNNVVVEDDAvakeaiELLKRRKAGRATFLPLNKMRDERRDLSILSEDGVIGFAVDLVEFDPKYE-- 613

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  935 STVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQ 1014
Cdd:TIGR02169  614 PAFKYVFGDTLVVEDIEAARRLMGKYRMVTLEGELFEKSGAMTGGSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSL 693

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1015 THKCRQRDEEVKKGKQENERLRADLAALQKELQdrnalaeEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEE 1094
Cdd:TIGR02169  694 QSELRRIENRLDELSQELSDASRKIGEIEKEIE-------QLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEAR 766

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1095 KAKQASEILAAQNLLQK-----QPVPLEQVEALKKSLNGTIEQLKEELRSkqrcLEREQQTVSQLQQLLENQKNSSVTLA 1169
Cdd:TIGR02169  767 IEELEEDLHKLEEALNDlearlSHSRIPEIQAELSKLEEEVSRIEARLRE----IEQKLNRLTLEKEYLEKEIQELQEQR 842

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1170 EHLKL-KEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETrevvDMSKYKATKNDLETQISNLNDK 1248
Cdd:TIGR02169  843 IDLKEqIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEA----QLRELERKIEELEAQIEKKRKR 918

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1270530344 1249 LASLNRKYdQACEEKVSAKDEKELLHLSIEQE---IRDQKERCDKSLTTIMEL 1298
Cdd:TIGR02169  919 LSELKAKL-EALEEELSEIEDPKGEDEEIPEEelsLEDVQAELQRVEEEIRAL 970
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 733-1409 1.37e-15

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 82.80  E-value: 1.37e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  733 QQVHSLTVEMKTRYVPL-RVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAERLlaeNDKLTKNVSRLEAvfvapekH 811
Cdd:TIGR02168  189 DRLEDILNELERQLKSLeRQAEKAERYKELKAELRELELALLVLRLEELREELEEL---QEELKEAEEELEE-------L 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  812 EKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLssqyvpaKTHEEVKASLNSTVEKTNRALLEAKKR 891
Cdd:TIGR02168  259 TAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQK-------QILRERLANLERQLEELEAQLEELESK 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  892 FDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKA 971
Cdd:TIGR02168  332 LDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLER 411

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  972 QKKELDTIQECIK--LKYAPLARLEECERKFKATEKGLKEQLSEQthkcRQRDEEVKKGKQENERLRADLAALQKELQDR 1049
Cdd:TIGR02168  412 LEDRRERLQQEIEelLKKLEEAELKELQAELEELEEELEELQEEL----ERLEEALEELREELEEAEQALDAAERELAQL 487

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1050 NALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKL-VEEKAKQASEILAAQNLLQ----KQPVPLEQVEALKK 1124
Cdd:TIGR02168  488 QARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELIsVDEGYEAAIEAALGGRLQAvvveNLNAAKKAIAFLKQ 567

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1125 SLNG------------------TIEQLKEELRSKQRCLEREQQT----------------VSQLQQLLENQKNSS----- 1165
Cdd:TIGR02168  568 NELGrvtflpldsikgteiqgnDREILKNIEGFLGVAKDLVKFDpklrkalsyllggvlvVDDLDNALELAKKLRpgyri 647

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1166 VTLAEHL-----------------------KLKEaLEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLET 1222
Cdd:TIGR02168  648 VTLDGDLvrpggvitggsaktnssilerrrEIEE-LEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSR 726

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1223 REVVDMSKYKATKN----------DLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLhlsiEQEIRDQKERCDKSL 1292
Cdd:TIGR02168  727 QISALRKDLARLEAeveqleeriaQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEEL----EAQIEQLKEELKALR 802

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1293 TTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLtyssgspTKRQSQLVDTLQQRVRDLQQQLADADRQH 1372
Cdd:TIGR02168  803 EALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQ-------IEELSEDIESLAAEIEELEELIEELESEL 875

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|..
gi 1270530344 1373 QEVIAIYRT-----HLLSAAQGHMDEDVQAALLQIIQMRQGL 1409
Cdd:TIGR02168  876 EALLNERASleealALLRSELEELSEELRELESKRSELRREL 917
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
762-1328 2.13e-15

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 81.65  E-value: 2.13e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  762 NVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQE 841
Cdd:PRK03918   180 RLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEE 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  842 KIRALMSENSSLKKTLssqyvpaKTHEEVKASLNStVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMK 921
Cdd:PRK03918   260 KIRELEERIEELKKEI-------EELEEKVKELKE-LKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIK 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  922 adyvSLEEHSRRMSTVSQSLKEAQEANAAIladhrqgqEEIVSLHAEIKAQKKELDTIQECIKLKyaplaRLEECERKFK 1001
Cdd:PRK03918   332 ----ELEEKEERLEELKKKLKELEKRLEEL--------EERHELYEEAKAKKEELERLKKRLTGL-----TPEKLEKELE 394

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1002 ATEKGlKEQLSEQTHKCRQRDEEVkkgKQENERLRADLAALQKE-----LQDRNALAEEAREAERALSGKADELSKQLKD 1076
Cdd:PRK03918   395 ELEKA-KEEIEEEISKITARIGEL---KKEIKELKKAIEELKKAkgkcpVCGRELTEEHRKELLEEYTAELKRIEKELKE 470

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1077 LSQKYSDVKSEREKlVEEKAKQASEILAAQNLlqkqpvpLEQVEALKKSLNG-TIEQLK------EELRSKQRCLEREQQ 1149
Cdd:PRK03918   471 IEEKERKLRKELRE-LEKVLKKESELIKLKEL-------AEQLKELEEKLKKyNLEELEkkaeeyEKLKEKLIKLKGEIK 542

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1150 TVSQLQQLLENQKNSSVTLAEHLK-LKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREvvdm 1228
Cdd:PRK03918   543 SLKKELEKLEELKKKLAELEKKLDeLEEELAELLKELEELGFESVEELEERLKELEPFYNEYLELKDAEKELEREE---- 618

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1229 SKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDE----KELLHLSIEQEI---RDQKERCDKSLTTIMELQQR 1301
Cdd:PRK03918   619 KELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSEEeyeeLREEYLELSRELaglRAELEELEKRREEIKKTLEK 698

                          570       580       590
                   ....*....|....*....|....*....|
gi 1270530344 1302 IQESAKQIEAKDNKITEL---LNDVERLKQ 1328
Cdd:PRK03918   699 LKEELEEREKAKKELEKLekaLERVEELRE 728
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 347-1252 9.96e-15

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 79.72  E-value: 9.96e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  347 ESEREKLKSLLAAKEKQHEESLRTIEALKNRfkyfesdhpgpgsypSNRKEDMLHKQGQMYTTEpqcaspgipphmHSRS 426
Cdd:TIGR02168  220 AELRELELALLVLRLEELREELEELQEELKE---------------AEEELEELTAELQELEEK------------LEEL 272

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  427 MLRPLELSlpsqtsyseneilkKELETLRTYYDSAKQDRLKFQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKD 506
Cdd:TIGR02168  273 RLEVSELE--------------EEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEE 338

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  507 VQkrmyESEGKVKQMQTHFLALKEHLTNEAAT--GSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKR 584
Cdd:TIGR02168  339 LA----ELEEKLEELKEELESLEAELEELEAEleELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLED 414

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  585 DEGRLVEENKRLQKEcgTCEVELERRGRRVVELEGQLKELGAKLalsvptEKFESMKSSLSNDINEKVKRLAEVGRDYES 664
Cdd:TIGR02168  415 RRERLQQEIEELLKK--LEEAELKELQAELEELEEELEELQEEL------ERLEEALEELREELEEAEQALDAAERELAQ 486

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  665 AQGEIRQLKRDLESVRAQHIRPEEHEQLRSRLEQKSGELGKKVS-----ELTLKNqTLQKDVEKLHADNK-LLNQQVHSL 738
Cdd:TIGR02168  487 LQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISvdegyEAAIEA-ALGGRLQAVVVENLnAAKKAIAFL 565

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  739 TVEMKTRYVPLRVSeemkkshDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVS-RLEAVFVAPEkhekelmg 817
Cdd:TIGR02168  566 KQNELGRVTFLPLD-------SIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSyLLGGVLVVDD-------- 630

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  818 LKSNIAELKKQLSELNKKCGEGQekiralmsensslkkTLSSQYVPAKTHEEVKASLNStvekTNRALLEAKKRFDDTSQ 897
Cdd:TIGR02168  631 LDNALELAKKLRPGYRIVTLDGD---------------LVRPGGVITGGSAKTNSSILE----RRREIEELEEKIEELEE 691

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  898 EVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELD 977
Cdd:TIGR02168  692 KIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLE 771

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  978 TIQEciklkyaplaRLEECERKfkatekglKEQLSEQThkcRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAR 1057
Cdd:TIGR02168  772 EAEE----------ELAEAEAE--------IEELEAQI---EQLKEELKALREALDELRAELTLLNEEAANLRERLESLE 830

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1058 EAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEEL 1137
Cdd:TIGR02168  831 RRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKR 910

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1138 RSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEkevgimkasLREKEEESQKKTKEVSKLQTEVQTTKQAL 1217
Cdd:TIGR02168  911 SELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLT---------LEEAEALENKIEDDEEEARRRLKRLENKI 981

                          890       900       910
                   ....*....|....*....|....*....|....*...
gi 1270530344 1218 KNLETREVVDMSKYKATK---NDLETQISNLNDKLASL 1252
Cdd:TIGR02168  982 KELGPVNLAAIEEYEELKeryDFLTAQKEDLTEAKETL 1019
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 77-229 2.17e-14

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 78.37  E-value: 2.17e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   77 VASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLC 156
Cdd:PLN03192   532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY 611

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1270530344  157 dHGASVNAKDIDGRTpLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLT 229
Cdd:PLN03192   612 -HFASISDPHAAGDL-LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVD 682
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 48-196 2.42e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 77.01  E-value: 2.42e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   48 DVEKVSSILAKKGVHPGKLDVEGRSAFHVVASK--GNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHA------LCL 119
Cdd:PHA03100    84 DVKEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIdlkilkLLI 163

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  120 QK------------LLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQL 187
Cdd:PHA03100   164 DKgvdinaknrvnyLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKL 243


                   ....*....
gi 1270530344  188 LIDRGADVN 196
Cdd:PHA03100   244 LLNNGPSIK 252
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 696-1324 6.15e-14

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 76.98  E-value: 6.15e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  696 LEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKtryvplrvseEMKKSHDVNVEDLNKKLSEatq 775
Cdd:TIGR04523   80 LEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQKNKLEVELN----------KLEKQKKENKKNIDKFLTE--- 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  776 rYTEKKQEAERLLAENDKLTKNVSRLEAVFvapEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIralmsensSLKK 855
Cdd:TIGR04523  147 -IKKKEKELEKLNNKYNDLKKQKEELENEL---NLLEKEKLNIQKNIDKIKNKLLKLELLLSNLKKKI--------QKNK 214

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  856 TLSSQYVPAKtheEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQmkadyvsLEEHSRRMS 935
Cdd:TIGR04523  215 SLESQISELK---KQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKE-------LEQNNKKIK 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  936 TVSqslKEAQEANAAILADHRQGQEEIVS-LHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGL------- 1007
Cdd:TIGR04523  285 ELE---KQLNQLKSEISDLNNQKEQDWNKeLKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSesensek 361

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1008 KEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSE 1087
Cdd:TIGR04523  362 QRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSE 441

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1088 REKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKqrclereqqtVSQLQQLLENQKNSSVT 1167
Cdd:TIGR04523  442 IKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSK----------EKELKKLNEEKKELEEK 511

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1168 LAEhlklkeaLEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVD-----MSKYKATKNDLEtqi 1242
Cdd:TIGR04523  512 VKD-------LTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDDFELKKENLEKEIDeknkeIEELKQTQKSLK--- 581

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1243 sNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERCDKSLTTIMELQ---QRIQESAKQIEAKDNKITEL 1319
Cdd:TIGR04523  582 -KKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKskkNKLKQEVKQIKETIKEIRNK 660


                   ....*
gi 1270530344 1320 LNDVE 1324
Cdd:TIGR04523  661 WPEII 665
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
447-1037 1.47e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 75.87  E-value: 1.47e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  447 LKKELETLRTYYDSAKQdRLKFQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQ---- 522
Cdd:PRK03918   212 ISSELPELREELEKLEK-EVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKelke 290

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  523 --THFLALKEhLTNEAATGSHRI----------IEELREQLKDLKGKyegaSAEVGKLRSQIKQSEMLVGEFKRDEgRLV 590
Cdd:PRK03918   291 kaEEYIKLSE-FYEEYLDELREIekrlsrleeeINGIEERIKELEEK----EERLEELKKKLKELEKRLEELEERH-ELY 364

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  591 EENKRLQKECGtcEVELERRGRRVVELEGQLKEL-GAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVgrdyESAQGEI 669
Cdd:PRK03918   365 EEAKAKKEELE--RLKKRLTGLTPEKLEKELEELeKAKEEIEEEISKITARIGELKKEIKELKKAIEEL----KKAKGKC 438

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  670 RQLKRDLESvraqhirpEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLhaDNKLLNQqvhSLTVEMKTRYVPL 749
Cdd:PRK03918   439 PVCGRELTE--------EHRKELLEEYTAELKRIEKELKEIEEKERKLRKELREL--EKVLKKE---SELIKLKELAEQL 505

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  750 RVSEEMKKSHDVnvedlnKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVfvapekhEKELMGLKSNIAELKKQL 829
Cdd:PRK03918   506 KELEEKLKKYNL------EELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEEL-------KKKLAELEKKLDELEEEL 572

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  830 SELNKKCGE-GQEKIRALMSENSSLKKtLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEV 908
Cdd:PRK03918   573 AELLKELEElGFESVEELEERLKELEP-FYNEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEE 651

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  909 LRRNLEnvqnqmKADYVSLEEHSRRMSTVSQSLKEAQEAnaaiLADHRqgqEEIVSLHAEIKAQKKELDTIQECIKLKYA 988
Cdd:PRK03918   652 LEKKYS------EEEYEELREEYLELSRELAGLRAELEE----LEKRR---EEIKKTLEKLKEELEEREKAKKELEKLEK 718

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|
gi 1270530344  989 PLARLEECERKFKATEKGLKEQ-LSEQTHKCRQRDEEVKKGKQENERLRA 1037
Cdd:PRK03918   719 ALERVEELREKVKKYKALLKERaLSKVGEIASEIFEELTEGKYSGVRVKA 768
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 487-1314 2.09e-13

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 75.54  E-value: 2.09e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  487 ERVKEDSDEQIKQLEDALKD-----------VQKRMYESEGKVKQMQTHFLALKEHLTNEAATGshriiEELREQLKDLK 555
Cdd:pfam15921   77 ERVLEEYSHQVKDLQRRLNEsnelhekqkfyLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQ-----EDLRNQLQNTV 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  556 GKYEGA-SAEVGKLRSQIKQSEMLVGEFKRDEGRLveenkrlqKECGTCEVELER-RGRRVVELEgqlkelgaklalSVP 633
Cdd:pfam15921  152 HELEAAkCLKEDMLEDSNTQIEQLRKMMLSHEGVL--------QEIRSILVDFEEaSGKKIYEHD------------SMS 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  634 TEKFESMKSSLSndinekvKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPEEH--EQLRSRLEQKSGELGKKVSELT 711
Cdd:pfam15921  212 TMHFRSLGSAIS-------KILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELllQQHQDRIEQLISEHEVEITGLT 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  712 LKNQTLQKDVEKLHADNKLLNQQVHSLTV-------EMKTRYVPLRVS-EEMKKSHDVNVEDLNKKLSEATQRYTEKKQE 783
Cdd:pfam15921  285 EKASSARSQANSIQSQLEIIQEQARNQNSmymrqlsDLESTVSQLRSElREAKRMYEDKIEELEKQLVLANSELTEARTE 364

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  784 AERLLAENDKLTKNVSRLEAVFvapEKHEKELmglksniaELKKqlsELNKKCGEGQEKIRALMSEnssLKKTLSSQYVP 863
Cdd:pfam15921  365 RDQFSQESGNLDDQLQKLLADL---HKREKEL--------SLEK---EQNKRLWDRDTGNSITIDH---LRRELDDRNME 427

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  864 AKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKE 943
Cdd:pfam15921  428 VQRLEALLKAMKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQE 507

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  944 AQEANAAILAdhrqgqeEIVSLHAEIKAQKKELDTIQ-ECIKLKYAPlarlEECER-KFKATEKG-LKEQLSEQTHKCRQ 1020
Cdd:pfam15921  508 KERAIEATNA-------EITKLRSRVDLKLQELQHLKnEGDHLRNVQ----TECEAlKLQMAEKDkVIEILRQQIENMTQ 576

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1021 RdeeVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLS--------------QKYSDVKS 1086
Cdd:pfam15921  577 L---VGQHGRTAGAMQVEKAQLEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLElekvklvnagserlRAVKDIKQ 653

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1087 EREKLVEEKAKQASEIlaaQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSV 1166
Cdd:pfam15921  654 ERDQLLNEVKTSRNEL---NSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAM 730

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1167 TLAEHLKLK----EALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTkqalknletreVVDMSKYKATKNDLETQI 1242
Cdd:pfam15921  731 GMQKQITAKrgqiDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTV-----------ATEKNKMAGELEVLRSQE 799

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1270530344 1243 SNLNDKLASLNRKYDQACEEKVSAKD-----EKELLHLSIEQEIrDQKERCDKSLTTIMELQQRIQESAKQIEAKDN 1314
Cdd:pfam15921  800 RRLKEKVANMEVALDKASLQFAECQDiiqrqEQESVRLKLQHTL-DVKELQGPGYTSNSSMKPRLLQPASFTRTHSN 875
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 776-1374 2.25e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 75.48  E-value: 2.25e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  776 RYTEKKQEAERLLAENDKltkNVSRLEAVfvapekhekelmglksnIAELKKQLSELNKKcGEGQEKIRALMSENSSLKK 855
Cdd:TIGR02168  169 KYKERRKETERKLERTRE---NLDRLEDI-----------------LNELERQLKSLERQ-AEKAERYKELKAELRELEL 227

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  856 TLSS-QYVPAKTH----EEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEH 930
Cdd:TIGR02168  228 ALLVlRLEELREEleelQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQIL 307

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  931 SRRMSTVSQSLKEAQEanaaILADHRQGQEEivsLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQ 1010
Cdd:TIGR02168  308 RERLANLERQLEELEA----QLEELESKLDE---LAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQ 380

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1011 LSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQdrNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREK 1090
Cdd:TIGR02168  381 LETLRSKVAQLELQIASLNNEIERLEARLERLEDRRE--RLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELER 458

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1091 LVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRS-KQRCLEREQ--QTVSQLQQLLENQKN---- 1163
Cdd:TIGR02168  459 LEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGvKALLKNQSGlsGILGVLSELISVDEGyeaa 538

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1164 SSVTLAEHL-----KLKEALEKEVGIMKASLREKE---EESQKKTKEVSKLQTEVQTTKQALKNLETREVVDMSKYKATK 1235
Cdd:TIGR02168  539 IEAALGGRLqavvvENLNAAKKAIAFLKQNELGRVtflPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKAL 618

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1236 NDL------ETQISNLNDKLASLNRKY-------DQACEEKVSAK--DEKELLHLSIEQEIRDQKERCDkslttimELQQ 1300
Cdd:TIGR02168  619 SYLlggvlvVDDLDNALELAKKLRPGYrivtldgDLVRPGGVITGgsAKTNSSILERRREIEELEEKIE-------ELEE 691

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1270530344 1301 RIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDLQQQLADADRQHQE 1374
Cdd:TIGR02168  692 KIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEE 765
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 89-228 2.35e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 74.71  E-value: 2.35e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   89 ILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCP-SSIQLLCDHGASVNAKDI 167
Cdd:PHA02876   361 LLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPyMSVKTLIDRGANVNSKNK 440

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1270530344  168 DGRTPLVLATQM-CRPTICQLLIDRGADVNSRDKQNRTALMLGCEYgcRDAVEVLVKNGADL 228
Cdd:PHA02876   441 DLSTPLHYACKKnCKLDVIEMLLDNGADVNAINIQNQYPLLIALEY--HGIVNILLHYGAEL 500
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 40-263 3.91e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 73.46  E-value: 3.91e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   40 LMKAAERGDVEKVSSILaKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCL 119
Cdd:PHA02874   128 LHYAIKKGDLESIKMLF-EYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACI 206

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  120 QKLLQYncpTEHVDLQ---GRTALHDAAMADcPSSIQLLCDHgASVNAKDIDGRTPLVLATQM-CRPTICQLLIDRGADV 195
Cdd:PHA02874   207 KLLIDH---GNHIMNKcknGFTPLHNAIIHN-RSAIELLINN-ASINDQDIDGSTPLHHAINPpCDIDIIDILLYHKADI 281

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1270530344  196 NSRDKQNRTALMLGCEYGCRDAV-------EVLVKNGADLTLLDALGHDSsyyarIGDNLDILNLLKTASENTNK 263
Cdd:PHA02874   282 SIKDNKGENPIDTAFKYINKDPVikdiianAVLIKEADKLKDSDFLEHIE-----IKDNKEFSDFIKECNEEIED 351
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 494-1297 3.99e-13

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 74.29  E-value: 3.99e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  494 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTNeaatgSHRIIEELREQLKDLKGKyegasaevgklrsqIK 573
Cdd:TIGR04523   32 DTEEKQLEKKLKTIKNELKNKEKELKNLDKNLNKDEEKINN-----SNNKIKILEQQIKDLNDK--------------LK 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  574 QSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERrgrrvveLEGQLKELGAKLAL-SVPTEKFESMKSSLSNDINEKV 652
Cdd:TIGR04523   93 KNKDKINKLNSDLSKINSEIKNDKEQKNKLEVELNK-------LEKQKKENKKNIDKfLTEIKKKEKELEKLNNKYNDLK 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  653 KRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLN 732
Cdd:TIGR04523  166 KQKEELENELNLLEKEKLNIQKNIDKIKNKLLKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKT 245

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  733 QQVHSLTVEMKTryvplrvseeMKKSHDVNVEDLNKKLSEATQryTEKKqeaerllaeNDKLTKNVSRLEAVFVA--PEK 810
Cdd:TIGR04523  246 TEISNTQTQLNQ----------LKDEQNKIKKQLSEKQKELEQ--NNKK---------IKELEKQLNQLKSEISDlnNQK 304

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  811 HEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSsqyvpaktheevkaSLNSTVEKTNRALLEAKk 890
Cdd:TIGR04523  305 EQDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELT--------------NSESENSEKQRELEEKQ- 369

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  891 rfddtsQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEanaailaDHRQGQEEIVSLHAEIK 970
Cdd:TIGR04523  370 ------NEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQ-------EKELLEKEIERLKETII 436

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  971 AQKKELDTIQECIklkyaplARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQdrn 1050
Cdd:TIGR04523  437 KNNSEIKDLTNQD-------SVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKK--- 506

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1051 alaeeareaeralsgkadELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPL--EQVEALKKSLNG 1128
Cdd:TIGR04523  507 ------------------ELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDDFELkkENLEKEIDEKNK 568

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1129 TIEQLKEElrskQRCLEREQQTVSQL-QQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQ 1207
Cdd:TIGR04523  569 EIEELKQT----QKSLKKKQEEKQELiDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLK 644

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1208 TEVQTTKQALKNLETREVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELL--HLSIEQEIRDQK 1285
Cdd:TIGR04523  645 QEVKQIKETIKEIRNKWPEIIKKIKESKTKIDDIIELMKDWLKELSLHYKKYITRMIRIKDLPKLEekYKEIEKELKKLD 724

                          810
                   ....*....|..
gi 1270530344 1286 ErCDKSLTTIME 1297
Cdd:TIGR04523  725 E-FSKELENIIK 735
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 300-1046 4.73e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 74.32  E-value: 4.73e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  300 SFQDLEIENEDLREKLRKIQQEQRILLDKVNGLQLQLNEevmvaddLESEREKLKSLLAAKEKQHEESLRTIEALKNRFK 379
Cdd:TIGR02168  233 RLEELREELEELQEELKEAEEELEELTAELQELEEKLEE-------LRLEVSELEEEIEELQKELYALANEISRLEQQKQ 305

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  380 YFesdhpgpgsypsNRKEDMLHKQGQMYTTEpqcaspgipphmhsrsmlrplelslpSQTSYSENEILKKELETLRTYYD 459
Cdd:TIGR02168  306 IL------------RERLANLERQLEELEAQ--------------------------LEELESKLDELAEELAELEEKLE 347

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  460 SAKQDRLKFQNELAHKVAECKALalecERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTNEAATG 539
Cdd:TIGR02168  348 ELKEELESLEAELEELEAELEEL----ESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEI 423

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  540 S--------------HRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQkecgTCEV 605
Cdd:TIGR02168  424 EellkkleeaelkelQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLE----RLQE 499

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  606 ELERRGRRVVELEGQLKELGAKLA-----LSVPtEKFE-SMKSSLSNDINekvkrlAEVGRDYESAQGEIRQLKRD---- 675
Cdd:TIGR02168  500 NLEGFSEGVKALLKNQSGLSGILGvlselISVD-EGYEaAIEAALGGRLQ------AVVVENLNAAKKAIAFLKQNelgr 572

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  676 -----LESVRAQHIRPEEHEQLRS---------RLEQKSGELGKKVSELtLKNQTLQKDVEKLHADNKLLNQQVHSLTVE 741
Cdd:TIGR02168  573 vtflpLDSIKGTEIQGNDREILKNiegflgvakDLVKFDPKLRKALSYL-LGGVLVVDDLDNALELAKKLRPGYRIVTLD 651

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  742 ---MKTRYVPLRVSEEMKKS---HDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAvfvAPEKHEKEL 815
Cdd:TIGR02168  652 gdlVRPGGVITGGSAKTNSSileRRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRK---ELEELSRQI 728

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  816 MGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDT 895
Cdd:TIGR02168  729 SALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDEL 808

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  896 SQEVSKLRDENEVLRRNLENVQNQMkadyvslEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKE 975
Cdd:TIGR02168  809 RAELTLLNEEAANLRERLESLERRI-------AATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNE 881

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1270530344  976 LDTIQEciklkyaPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKEL 1046
Cdd:TIGR02168  882 RASLEE-------ALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERL 945
PHA03095 PHA03095
ankyrin-like protein; Provisional
 44-254 5.86e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 73.14  E-value: 5.86e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   44 AERGDVEKVSSILAKKGvhpgklDVE-----GRSAFHVVASKGN---LECLNAILTHGIDVATRDSAGRNALHLAAKYGH 115
Cdd:PHA03095    22 ASNVTVEEVRRLLAAGA------DVNfrgeyGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNAT 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  116 ALCLQKLL-QYNCPTEHVDLQGRTALHDAAMADC--PSSIQLLCDHGASVNAKDIDGRTPL--VLATQMCRPTICQLLID 190
Cdd:PHA03095    96 TLDVIKLLiKAGADVNAKDKVGRTPLHVYLSGFNinPKVIRLLLRKGADVNALDLYGMTPLavLLKSRNANVELLRLLID 175

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  191 RGADVNSRDKQNRTALMLGCEYgCRD---AVEVLVKNGADLTLLDALGHDSSYYARIGD---NLDILNLL 254
Cdd:PHA03095   176 AGADVYAVDDRFRSLLHHHLQS-FKPrarIVRELIRAGCDPAATDMLGNTPLHSMATGSsckRSLVLPLL 244
Ank_2 pfam12796
Ankyrin repeats (3 copies);
40-127 1.01e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 65.14  E-value: 1.01e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   40 LMKAAERGDVEKVSsILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIdvATRDSAGRNALHLAAKYGHALCL 119
Cdd:pfam12796    1 LHLAAKNGNLELVK-LLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLEIV 77


                   ....*...
gi 1270530344  120 QKLLQYNC 127
Cdd:pfam12796   78 KLLLEKGA 85
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 438-1213 1.48e-12

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 72.84  E-value: 1.48e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  438 QTSYSENEILKKELETLRTYYDSAKQDrlkFQNELAHKVAECKALALECERVKEDSDEQIKQLedalkdvQKRMYESEGK 517
Cdd:pfam15921  116 QTKLQEMQMERDAMADIRRRESQSQED---LRNQLQNTVHELEAAKCLKEDMLEDSNTQIEQL-------RKMMLSHEGV 185

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  518 VKQMQTHFLALKE---------------HLTNeAATGSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQS-EMLVGE 581
Cdd:pfam15921  186 LQEIRSILVDFEEasgkkiyehdsmstmHFRS-LGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKiELLLQQ 264

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  582 FKRDEGRLVEENKrlqkecgtcevelerrgrrvVELEGQlkelgaklalsvpTEKFESMKSSlSNDINEKVKRLAEVGRD 661
Cdd:pfam15921  265 HQDRIEQLISEHE--------------------VEITGL-------------TEKASSARSQ-ANSIQSQLEIIQEQARN 310

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  662 YESAQgeIRQLKrDLESVRAQhIRPEEHEQLRSrLEQKSGELGKkvsELTLKNQTL---QKDVEKLHADNKLLNQQVHSL 738
Cdd:pfam15921  311 QNSMY--MRQLS-DLESTVSQ-LRSELREAKRM-YEDKIEELEK---QLVLANSELteaRTERDQFSQESGNLDDQLQKL 382

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  739 TVEMKTRYVPLRVSEEMkkshdvnvedlNKKLSEatqRYTEKKQEAERLLAENDKLTKNVSRLEAVFVAPE-----KHEK 813
Cdd:pfam15921  383 LADLHKREKELSLEKEQ-----------NKRLWD---RDTGNSITIDHLRRELDDRNMEVQRLEALLKAMKsecqgQMER 448

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  814 ELMGLKSNIAELKKqLSELNKKCGEGQEKIRALMSENSSLKKTLSSQyvpAKTHEEVKASLNS---TVEKTNRALLEAKK 890
Cdd:pfam15921  449 QMAAIQGKNESLEK-VSSLTAQLESTKEMLRKVVEELTAKKMTLESS---ERTVSDLTASLQEkerAIEATNAEITKLRS 524

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  891 RFDDTSQEVSKLRDENEVLRrnleNVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIK 970
Cdd:pfam15921  525 RVDLKLQELQHLKNEGDHLR----NVQTECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEIN 600

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  971 AQKKELdtiQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQrdeeVKKGKQENERLRADLAALQKELQDRN 1050
Cdd:pfam15921  601 DRRLEL---QEFKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRA----VKDIKQERDQLLNEVKTSRNELNSLS 673

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1051 ALAEEAREAERALSGKADELSKQLK-DLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNgT 1129
Cdd:pfam15921  674 EDYEVLKRNFRNKSEEMETTTNKLKmQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQ-F 752

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1130 IEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNS-----SVTLAEHLKLKEALEK-EVGIMKASLREKEEESQKKTKEV 1203
Cdd:pfam15921  753 LEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKmagelEVLRSQERRLKEKVANmEVALDKASLQFAECQDIIQRQEQ 832

                          810
                   ....*....|
gi 1270530344 1204 SKLQTEVQTT 1213
Cdd:pfam15921  833 ESVRLKLQHT 842
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
496-1171 1.72e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 72.40  E-value: 1.72e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  496 QIKQLEDALKDVQKRMYESEGKVKQMQThFLALKEHLTNEAATGSHRIIEELREqLKDLKGKYEGASAEVGKLRSQIKQS 575
Cdd:PRK03918   156 GLDDYENAYKNLGEVIKEIKRRIERLEK-FIKRTENIEELIKEKEKELEEVLRE-INEISSELPELREELEKLEKEVKEL 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  576 EMLVGEFKRdegrLVEENKRLQKECGTCEVELERRGRRVVELEGQLKELgaklalsvpTEKFESMKSslsndINEKVKRL 655
Cdd:PRK03918   234 EELKEEIEE----LEKELESLEGSKRKLEEKIRELEERIEELKKEIEEL---------EEKVKELKE-----LKEKAEEY 295

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  656 AEVGRDYESAQGEIRQLKRDLESVRAQHIRPEEHEQLRSRLEQKSGELGKKVSEltlknqtLQKDVEKLHADNKLLnQQV 735
Cdd:PRK03918   296 IKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKE-------LEKRLEELEERHELY-EEA 367

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  736 HSLTVEMKtryvplrvsEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAERLLAendkltknvsrleavfvapekhekEL 815
Cdd:PRK03918   368 KAKKEELE---------RLKKRLTGLTPEKLEKELEELEKAKEEIEEEISKITA------------------------RI 414

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  816 MGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENsslKKTLSSQYvpaktHEEVKaSLNSTVEKTNRALLEAKKRFddt 895
Cdd:PRK03918   415 GELKKEIKELKKAIEELKKAKGKCPVCGRELTEEH---RKELLEEY-----TAELK-RIEKELKEIEEKERKLRKEL--- 482

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  896 sQEVSKLRDENEVLRRNLEnVQNQMKADYVSLEEHsrrmstvsqSLKEAQEANaailADHRQGQEEIVSLHAEIKAQKKE 975
Cdd:PRK03918   483 -RELEKVLKKESELIKLKE-LAEQLKELEEKLKKY---------NLEELEKKA----EEYEKLKEKLIKLKGEIKSLKKE 547

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  976 LDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLR---ADLAALQKELQDRNAL 1052
Cdd:PRK03918   548 LEKLEELKKKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELEPFYNEYLELKdaeKELEREEKELKKLEEE 627

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1053 AEEAREAERALSGKADELSKQLKDLSQKYSDvkSEREKLVEEKAKQASEILAAQNllqkqpvPLEQVEALKKSLNGTIEQ 1132
Cdd:PRK03918   628 LDKAFEELAETEKRLEELRKELEELEKKYSE--EEYEELREEYLELSRELAGLRA-------ELEELEKRREEIKKTLEK 698

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|..
gi 1270530344 1133 LKEEL---RSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEH 1171
Cdd:PRK03918   699 LKEELeerEKAKKELEKLEKALERVEELREKVKKYKALLKER 740
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1066-1409 2.12e-12

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 72.28  E-value: 2.12e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1066 KADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQpvpLEQVEALKKSLNGTIEQLKEELRSKQRCLE 1145
Cdd:COG1196    233 KLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEEL---ELELEEAQAEEYELLAELARLEQDIARLEE 309

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1146 REQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEE---ESQKKTKEVSKLQTEVQTTKQALKNLET 1222
Cdd:COG1196    310 RRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAelaEAEEALLEAEAELAEAEEELEELAEELL 389

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1223 REVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERcdksLTTIMELQQRI 1302
Cdd:COG1196    390 EALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAEL----EEEEEALLELL 465

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1303 QESAKQIEAKDNKITELLNDVERLKQALNGLSQLTyssgspTKRQSQLVDTLQQRVRDLQQQLADADRQHQEVIAIYRTH 1382
Cdd:COG1196    466 AELLEEAALLEAALAELLEELAEAAARLLLLLEAE------ADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAA 539

                          330       340
                   ....*....|....*....|....*..
gi 1270530344 1383 LLSAAQGHMDEDVQAALLQIIQMRQGL 1409
Cdd:COG1196    540 LEAALAAALQNIVVEDDEVAAAAIEYL 566
PHA03095 PHA03095
ankyrin-like protein; Provisional
 47-247 5.82e-12

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 69.67  E-value: 5.82e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   47 GDVEKVSSILAKKGVHPGKLDVEGRSAFHVVASKGN-LECLNAILTHGIDVATRDSAGRNALH--LAAKYGHALCLQKLL 123
Cdd:PHA03095    60 EKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTPLHvyLSGFNINPKVIRLLL 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  124 QYNCPTEHVDLQGRTALH------DAamadCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRP--TICQLLIDRGADV 195
Cdd:PHA03095   140 RKGADVNALDLYGMTPLAvllksrNA----NVELLRLLIDAGADVYAVDDRFRSLLHHHLQSFKPraRIVRELIRAGCDP 215

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1270530344  196 NSRDKQNRTALMLGCEYG-CRDA-VEVLVKNGADLTLLDALGHDSSYYARIGDN 247
Cdd:PHA03095   216 AATDMLGNTPLHSMATGSsCKRSlVLPLLIAGISINARNRYGQTPLHYAAVFNN 269
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 442-1290 6.95e-12

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 70.48  E-value: 6.95e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  442 SENEILKKELETLRTYYDSAKQDRLKFQNELAHKVAECKALalecERVKEDSDEQIKQL-EDALKDVQKRMYESEGKVKQ 520
Cdd:TIGR02169  230 KEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEI----EQLLEELNKKIKDLgEEEQLRVKEKIGELEAEIAS 305

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  521 MQthflalkehltneaatgshRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKEC 600
Cdd:TIGR02169  306 LE-------------------RSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEEL 366

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  601 GTCEVELERRGRRVVELEGQLKELGAKL---------------ALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESA 665
Cdd:TIGR02169  367 EDLRAELEEVDKEFAETRDELKDYREKLeklkreinelkreldRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDK 446

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  666 QGEIRQLKRDLESVRAQHIRPE-EHEQLRSRLEQKSGELGKKVSELtlknqtlqkdvEKLHADNKLLNQQVHSltvemkt 744
Cdd:TIGR02169  447 ALEIKKQEWKLEQLAADLSKYEqELYDLKEEYDRVEKELSKLQREL-----------AEAEAQARASEERVRG------- 508

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  745 ryvpLRVSEEMKKSHDVNVEDLNKKLSEATQRYtekkQEAERLLAENdkltknvsRLEAVFVAPEKHEKELmglksnIAE 824
Cdd:TIGR02169  509 ----GRAVEEVLKASIQGVHGTVAQLGSVGERY----ATAIEVAAGN--------RLNNVVVEDDAVAKEA------IEL 566

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  825 LKKqlselnKKCGEGQ----EKIRALMSENSSLKK-----------TLSSQYVPAktheeVKASLNSTVEKTNralLEAK 889
Cdd:TIGR02169  567 LKR------RKAGRATflplNKMRDERRDLSILSEdgvigfavdlvEFDPKYEPA-----FKYVFGDTLVVED---IEAA 632

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  890 KRFDDTSQEVSKlrdENEVLRRN-----LENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEanaAILADHRQGQEEIVS 964
Cdd:TIGR02169  633 RRLMGKYRMVTL---EGELFEKSgamtgGSRAPRGGILFSRSEPAELQRLRERLEGLKRELS---SLQSELRRIENRLDE 706

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  965 LHAEIKAQKKELDTIQeciklkyAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQK 1044
Cdd:TIGR02169  707 LSQELSDASRKIGEIE-------KEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEE 779

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1045 ELQDrnALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEIlaaQNLLQKQpvplEQVEALKK 1124
Cdd:TIGR02169  780 ALND--LEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEI---QELQEQR----IDLKEQIK 850

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1125 SLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKnssvtlaehlKLKEALEKEVGIMKASLREKEEESQKKTKEVS 1204
Cdd:TIGR02169  851 SIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLK----------KERDELEAQLRELERKIEELEAQIEKKRKRLS 920

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1205 KLQTEVQTTKQALKNLE---------TREVVDMSKYKATKNDLETQISnlndKLASLNRKYDQACEEKVSAKDEKELLHL 1275
Cdd:TIGR02169  921 ELKAKLEALEEELSEIEdpkgedeeiPEEELSLEDVQAELQRVEEEIR----ALEPVNMLAIQEYEEVLKRLDELKEKRA 996

                          890
                   ....*....|....*
gi 1270530344 1276 SIEQEIRDQKERCDK 1290
Cdd:TIGR02169  997 KLEEERKAILERIEE 1011
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 50-237 7.64e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 69.22  E-value: 7.64e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   50 EKVSSILaKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPT 129
Cdd:PHA02874   105 DMIKTIL-DCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYA 183

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  130 EHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTIcQLLIDrGADVNSRDKQNRTALMLG 209
Cdd:PHA02874   184 NVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAI-ELLIN-NASINDQDIDGSTPLHHA 261

                          170       180
                   ....*....|....*....|....*....
gi 1270530344  210 CEYGC-RDAVEVLVKNGADLTLLDALGHD 237
Cdd:PHA02874   262 INPPCdIDIIDILLYHKADISIKDNKGEN 290
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 74-254 7.73e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 69.31  E-value: 7.73e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   74 FHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQK-----LLQYNCPTEHVDLQGRTALHDAAMADC 148
Cdd:PHA03100    39 LYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLTDVKeivklLLEYGANVNAPDNNGITPLLYAISKKS 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  149 --PSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPT--ICQLLIDRGAD----------------VNSRDKQNRTALML 208
Cdd:PHA03100   119 nsYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVDinaknrvnyllsygvpINIKDVYGFTPLHY 198

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1270530344  209 GCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNLL 254
Cdd:PHA03100   199 AVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLL 244
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 544-901 7.92e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 70.47  E-value: 7.92e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  544 IEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDE-------GRLVEENKRLQKECGTCEVELERRGRRVVE 616
Cdd:TIGR02168  679 IEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELeelsrqiSALRKDLARLEAEVEQLEERIAQLSKELTE 758

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  617 LEGQLKELGAKLALSVPTEK-FESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAqhiRPEEHEQLRSR 695
Cdd:TIGR02168  759 LEAEIEELEERLEEAEEELAeAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRE---RLESLERRIAA 835

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  696 LEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQ 775
Cdd:TIGR02168  836 TERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRR 915

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  776 RYTEKKQEAERLLAENDKLTKNVSRLEAVFvaPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRAL-------MS 848
Cdd:TIGR02168  916 ELEELREKLAQLELRLEGLEVRIDNLQERL--SEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKELgpvnlaaIE 993

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1270530344  849 ENSSLKK---TLSSQYVPAkthEEVKASLNSTVEKTNRallEAKKRFDDTSQEVSK 901
Cdd:TIGR02168  994 EYEELKErydFLTAQKEDL---TEAKETLEEAIEEIDR---EARERFKDTFDQVNE 1043
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 776-1366 1.18e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 69.58  E-value: 1.18e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  776 RYTEKKQEAERLLAE--------NDK---LTKNVSRLE--------AVFVAPEKHEKELMGLKSNIAELKKQLSELNKKC 836
Cdd:COG1196    169 KYKERKEEAERKLEAteenlerlEDIlgeLERQLEPLErqaekaerYRELKEELKELEAELLLLKLRELEAELEELEAEL 248

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  837 GEGQEKIRALMSENSSLKKTLSSQyvpakthEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENV 916
Cdd:COG1196    249 EELEAELEELEAELAELEAELEEL-------RLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEEL 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  917 QNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQEciklkyaplARLEEc 996
Cdd:COG1196    322 EEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAE---------ELLEA- 391

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  997 erkfKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKD 1076
Cdd:COG1196    392 ----LRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAE 467

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1077 LSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQV-EALKKSLNGTIEQLKEELRSKQRCLE---------- 1145
Cdd:COG1196    468 LLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVkAALLLAGLRGLAGAVAVLIGVEAAYEaaleaalaaa 547

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1146 ------REQQTVSQLQQLLENQKNSSVTLAEHLKLK-----EALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTK 1214
Cdd:COG1196    548 lqnivvEDDEVAAAAIEYLKAAKAGRATFLPLDKIRaraalAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTL 627

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1215 QALKNLETREVVDMSKYKATKNDLETQISNLNDKLASLNRKydQACEEKVSAKDEKELLHLSIEQEIRDQKERCDKSLTT 1294
Cdd:COG1196    628 VAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRR--ELLAALLEAEAELEELAERLAEEELELEEALLAEEEE 705

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1270530344 1295 IMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDLQQQLA 1366
Cdd:COG1196    706 ERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIE 777
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 543-1139 4.24e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 68.04  E-value: 4.24e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  543 IIEELREQLKDLKG------KYEGASAEVGKLRSQ-----IKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERRG 611
Cdd:COG1196    194 ILGELERQLEPLERqaekaeRYRELKEELKELEAEllllkLRELEAELEELEAELEELEAELEELEAELAELEAELEELR 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  612 RRVVELEGQLKELGAKLALSvptekfESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRaqhirpEEHEQ 691
Cdd:COG1196    274 LELEELELELEEAQAEEYEL------LAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELE------EELEE 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  692 LRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLS 771
Cdd:COG1196    342 LEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEE 421

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  772 EATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKcgEGQEKIRALMSENS 851
Cdd:COG1196    422 ELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEE--LAEAAARLLLLLEA 499

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  852 SLKKTLSSQYVPAKTHEEVKASLNSTVektnrALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQmkADYVSLEEHS 931
Cdd:COG1196    500 EADYEGFLEGVKAALLLAGLRGLAGAV-----AVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAA--IEYLKAAKAG 572

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  932 RRmsTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQL 1011
Cdd:COG1196    573 RA--TFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVT 650

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1012 SEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKL 1091
Cdd:COG1196    651 LEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQL 730

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*...
gi 1270530344 1092 VEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRS 1139
Cdd:COG1196    731 EAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEA 778
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 48-227 5.34e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 66.55  E-value: 5.34e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   48 DVEKVSsILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGI---DVATRDsaGRNALHLAAKYGHALCLQKLLQ 124
Cdd:PHA02875    47 DSEAIK-LLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKfadDVFYKD--GMTPLHLATILKKLDIMKLLIA 123

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  125 YNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRT 204
Cdd:PHA02875   124 RGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCV 203

                          170       180
                   ....*....|....*....|....
gi 1270530344  205 ALM-LGCEYGCRDAVEVLVKNGAD 227
Cdd:PHA02875   204 AALcYAIENNKIDIVRLFIKRGAD 227
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 39-272 5.44e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 67.40  E-value: 5.44e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   39 RLMKAAERGDVEKVSSILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALC 118
Cdd:PHA02876   147 KLIKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDT 226

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  119 LQKLLQYNCPTEHVDLQGRTALHDaamADCPSSIqLLCDHGASVNAKDIDGRTPLVLATQMcrPTICQL---LIDRGADV 195
Cdd:PHA02876   227 IKAIIDNRSNINKNDLSLLKAIRN---EDLETSL-LLYDAGFSVNSIDDCKNTPLHHASQA--PSLSRLvpkLLERGADV 300

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1270530344  196 NSRDKQNRTALMLGCEYGC-RDAVEVLVKNGADLTLLDALGHDSSYYARIGD-NLDILNLLKTASENTNkGRELWRKGP 272
Cdd:PHA02876   301 NAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHQASTLDrNKDIVITLLELGANVN-ARDYCDKTP 378
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 56-283 9.07e-11

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 66.82  E-value: 9.07e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   56 LAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLlqYNCPTEHVDLQ 135
Cdd:PLN03192   544 LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRIL--YHFASISDPHA 621

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  136 GRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADV---NSRDKQNRTALMlgcey 212
Cdd:PLN03192   622 AGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVdkaNTDDDFSPTELR----- 696

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1270530344  213 gcrdavEVLVKN--GADLTLLDALGHDSSYYARIGDNLDiLNLLKTASENTNKGRELWRKGPPLQQRNLSHTQ 283
Cdd:PLN03192   697 ------ELLQKRelGHSITIVDSVPADEPDLGRDGGSRP-GRLQGTSSDNQCRPRVSIYKGHPLLRNERCCNE 762
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 82-242 2.05e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.60  E-value: 2.05e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   82 NLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGAS 161
Cdd:PHA02874   103 EKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAY 182

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  162 VNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGcRDAVEVLVKNgADLTLLDALGHDSSYY 241
Cdd:PHA02874   183 ANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHN-RSAIELLINN-ASINDQDIDGSTPLHH 260


                   .
gi 1270530344  242 A 242
Cdd:PHA02874   261 A 261
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
879-1375 4.15e-10

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 64.68  E-value: 4.15e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  879 EKTNRALLEAKKRFDDTSQEVSKLRDE-NEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQ 957
Cdd:PRK02224   169 ERASDARLGVERVLSDQRGSLDQLKAQiEEKEEKDLHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEE 248

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  958 GQEEIVSLHAEIKaqkKELDTIQECIKLKYAplarLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRA 1037
Cdd:PRK02224   249 RREELETLEAEIE---DLRETIAETEREREE----LAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELED 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1038 DLAALQKELQDR-------NALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQ 1110
Cdd:PRK02224   322 RDEELRDRLEECrvaaqahNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFG 401

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1111 KQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQK----NSSVTLAEHLKLKEALEKEVGIMK 1186
Cdd:PRK02224   402 DAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEAGKcpecGQPVEGSPHVETIEEDRERVEELE 481

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1187 ASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVD--MSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKV 1264
Cdd:PRK02224   482 AELEDLEEEVEEVEERLERAEDLVEAEDRIERLEERREDLEelIAERRETIEEKRERAEELRERAAELEAEAEEKREAAA 561

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1265 SAKDEKEllhlsieqEIRDQKERCDKSLTtimELQQRIqESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYSS---- 1340
Cdd:PRK02224   562 EAEEEAE--------EAREEVAELNSKLA---ELKERI-ESLERIRTLLAAIADAEDEIERLREKREALAELNDERrerl 629

                          490       500       510
                   ....*....|....*....|....*....|....*.
gi 1270530344 1341 GSPTKRQSQLVDTLQQ-RVRDLQQQLADADRQHQEV 1375
Cdd:PRK02224   630 AEKRERKRELEAEFDEaRIEEAREDKERAEEYLEQV 665
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 441-1321 6.23e-10

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 64.22  E-value: 6.23e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  441 YSENEILKKELETLRTYYDSAKQ----DRLKFQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEG 516
Cdd:pfam02463  165 SRLKRKKKEALKKLIEETENLAEliidLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQE 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  517 KVKQMQTHFLALKEHLTNEAATgSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRL 596
Cdd:pfam02463  245 LLRDEQEEIESSKQEIEKEEEK-LAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEK 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  597 QKEcgtcEVELERRGRRVVELEGQLKELGAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDL 676
Cdd:pfam02463  324 KKA----EKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELEL 399

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  677 ESVRAQHIRPEEHeqlrsRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEmktryvplrvsEEMK 756
Cdd:pfam02463  400 KSEEEKEAQLLLE-----LARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELK-----------LLKD 463

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  757 KSHDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKC 836
Cdd:pfam02463  464 ELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKV 543

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  837 GEGQEKIRALMSENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENV 916
Cdd:pfam02463  544 AISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAK 623

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  917 QNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEeiVSLHAEIKAQKKELDTIQECIKLKYAPLARLEEC 996
Cdd:pfam02463  624 VVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKAS--LSELTKELLEIQELQEKAESELAKEEILRRQLEI 701

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  997 ERKFKATEKGLKEQLSEQTH-KCRQRDEEVKKGKQENERLRADLAALQKELQdrnalaeeaREAERALSGKADELSKQLK 1075
Cdd:pfam02463  702 KKKEQREKEELKKLKLEAEElLADRVQEAQDKINEELKLLKQKIDEEEEEEE---------KSRLKKEEKEEEKSELSLK 772

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1076 DLSQKYSDVKSEREKLVEEKAKQaseILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQ 1155
Cdd:pfam02463  773 EKELAEEREKTEKLKVEEEKEEK---LKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLE 849

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1156 QLLENQKNSSV-TLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVDMSKYKAT 1234
Cdd:pfam02463  850 KLAEEELERLEeEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEI 929

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1235 KNDLETQISNL----NDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERCDKSLTTIMELQQRIQESAKQIE 1310
Cdd:pfam02463  930 LLKYEEEPEELlleeADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIR 1009

                          890
                   ....*....|.
gi 1270530344 1311 AKDNKITELLN 1321
Cdd:pfam02463 1010 AIIEETCQRLK 1020
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 448-804 7.02e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 63.92  E-value: 7.02e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  448 KKELETLRTYYDSAKQDRLKFQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEgKVKQMQTHFLA 527
Cdd:TIGR02168  676 RREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVE-QLEERIAQLSK 754

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  528 LKEHLTNEAATGSHRIIE------ELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECG 601
Cdd:TIGR02168  755 ELTELEAEIEELEERLEEaeeelaEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIA 834

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  602 TCEVELERRGRRVVELEGQLKELGAKLAlsvptekfesmksSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRA 681
Cdd:TIGR02168  835 ATERRLEDLEEQIEELSEDIESLAAEIE-------------ELEELIEELESELEALLNERASLEEALALLRSELEELSE 901

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  682 QHirpEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHAdnKLLNQqvHSLTVEMKTRYVPLRVSEEMKKSHDv 761
Cdd:TIGR02168  902 EL---RELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQE--RLSEE--YSLTLEEAEALENKIEDDEEEARRR- 973

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 1270530344  762 nVEDLNKKLSE-------ATQRYTEKKQEAERLLAENDKLTKNVSRLEAV 804
Cdd:TIGR02168  974 -LKRLENKIKElgpvnlaAIEEYEELKERYDFLTAQKEDLTEAKETLEEA 1022
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
765-1328 8.76e-10

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 63.52  E-value: 8.76e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  765 DLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELkkqlselnkkcgegQEKIR 844
Cdd:PRK02224   203 DLHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREELETLEAEIEDL--------------RETIA 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  845 ALMSENSSLKKTLSSQyvpAKTHEEVKASLNSTVEKTNRALLEAkkrfDDTSQEVSKLRDENEVLRRNLENVQNQMKADY 924
Cdd:PRK02224   269 ETEREREELAEEVRDL---RERLEELEEERDDLLAEAGLDDADA----EAVEARREELEDRDEELRDRLEECRVAAQAHN 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  925 VSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATE 1004
Cdd:PRK02224   342 EEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREER 421

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1005 KGLKEQLSEQTHKCRQRDEEVkkgkQENERLRAdlaalqkelqdrnalaeeareaeralSGKADELSKQLKDlsqkysdv 1084
Cdd:PRK02224   422 DELREREAELEATLRTARERV----EEAEALLE--------------------------AGKCPECGQPVEG-------- 463

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1085 kSEREKLVEEKAKQASEILAAqnllqkqpvpLEQVEALKKSLNGTIEQLkEELRSKQRCLEREQQTVSQLQQLLENQKNS 1164
Cdd:PRK02224   464 -SPHVETIEEDRERVEELEAE----------LEDLEEEVEEVEERLERA-EDLVEAEDRIERLEERREDLEELIAERRET 531

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1165 ----SVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVDmskykATKNDLET 1240
Cdd:PRK02224   532 ieekRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLERIRTLL-----AAIADAED 606

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1241 QISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIE----QEIRDQKERCDKSLTTIMELQQRIQES----AKQIEAK 1312
Cdd:PRK02224   607 EIERLREKREALAELNDERRERLAEKRERKRELEAEFDeariEEAREDKERAEEYLEQVEEKLDELREErddlQAEIGAV 686

                          570
                   ....*....|....*.
gi 1270530344 1313 DNKITELLNDVERLKQ 1328
Cdd:PRK02224   687 ENELEELEELRERREA 702
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 781-1335 1.60e-09

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 62.83  E-value: 1.60e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  781 KQEAERLLAENDKLTKNVSRleAVFVAPEKHEKELMGLKSNIAELKKQLSELN----------KKCGEGQEKIRalmsen 850
Cdd:pfam15921   73 KEHIERVLEEYSHQVKDLQR--RLNESNELHEKQKFYLRQSVIDLQTKLQEMQmerdamadirRRESQSQEDLR------ 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  851 SSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLE-------------------AKKRFDDTSQEVSKLRDENEVLRR 911
Cdd:pfam15921  145 NQLQNTVHELEAAKCLKEDMLEDSNTQIEQLRKMMLShegvlqeirsilvdfeeasGKKIYEHDSMSTMHFRSLGSAISK 224

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  912 NLENVQNQ---MKADYVSLEEHSRRMSTVSQS-----LKEAQEANAAILADHrqgQEEIVSLHAEIKAQKKELDTIQeci 983
Cdd:pfam15921  225 ILRELDTEisyLKGRIFPVEDQLEALKSESQNkiellLQQHQDRIEQLISEH---EVEITGLTEKASSARSQANSIQ--- 298

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  984 klkyaplARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERlraDLAALQKELQDRNALAEEAREAERAL 1063
Cdd:pfam15921  299 -------SQLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYED---KIEELEKQLVLANSELTEARTERDQF 368

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1064 SGKA----DELSKQLKDLSQKYSDVKSERE---KLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSL----NGTIEQ 1132
Cdd:pfam15921  369 SQESgnldDQLQKLLADLHKREKELSLEKEqnkRLWDRDTGNSITIDHLRRELDDRNMEVQRLEALLKAMksecQGQMER 448

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1133 LKEELRSKQRCLEReqqtVSQLQQLLENQKNSSVTLAEHLKLK----EALEKEVGIMKASLREKEEESQKKTKEVSKLQT 1208
Cdd:pfam15921  449 QMAAIQGKNESLEK----VSSLTAQLESTKEMLRKVVEELTAKkmtlESSERTVSDLTASLQEKERAIEATNAEITKLRS 524

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1209 EVQTTKQALKNLETRE--------VVDMSKYKATKND-----LETQISNLNDKLASLNRKYDQACEEKvsAKDEKELLHL 1275
Cdd:pfam15921  525 RVDLKLQELQHLKNEGdhlrnvqtECEALKLQMAEKDkvieiLRQQIENMTQLVGQHGRTAGAMQVEK--AQLEKEINDR 602

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1270530344 1276 SIE-QEIRDQKercDKSLTTIMELQQRIQ----ESAKQIEAKDNKI----------TELLNDVERLKQALNGLSQ 1335
Cdd:pfam15921  603 RLElQEFKILK---DKKDAKIRELEARVSdlelEKVKLVNAGSERLravkdikqerDQLLNEVKTSRNELNSLSE 674
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 636-1378 3.52e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 61.62  E-value: 3.52e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  636 KFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHirpeehEQLRSRLEQKSGELGKKvseltLKNQ 715
Cdd:TIGR02169  146 DFISMSPVERRKIIDEIAGVAEFDRKKEKALEELEEVEENIERLDLII------DEKRQQLERLRREREKA-----ERYQ 214

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  716 TLQKDVEKLHADNKLLNQQVHsltvemktryvplrvsEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLT 795
Cdd:TIGR02169  215 ALLKEKREYEGYELLKEKEAL----------------ERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELN 278

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  796 KNVSRL---EAVFVAPEKHE--KELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSSQYVPAKTHEEV 870
Cdd:TIGR02169  279 KKIKDLgeeEQLRVKEKIGEleAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEE 358

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  871 KASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLenvqNQMKADYVSLEEHSRRMstvSQSLKEAQEANAA 950
Cdd:TIGR02169  359 YAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREI----NELKRELDRLQEELQRL---SEELADLNAAIAG 431

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  951 ILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQ 1030
Cdd:TIGR02169  432 IEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRA 511

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1031 ENERLRADLAALQKELQDRNALAEEAREAERALSG---------------KADELSKQLK-------------------- 1075
Cdd:TIGR02169  512 VEEVLKASIQGVHGTVAQLGSVGERYATAIEVAAGnrlnnvvveddavakEAIELLKRRKagratflplnkmrderrdls 591

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1076 ---------------DLSQKY--------------SDVKSEREKLVE-----------EKA--------KQASEILAAQN 1107
Cdd:TIGR02169  592 ilsedgvigfavdlvEFDPKYepafkyvfgdtlvvEDIEAARRLMGKyrmvtlegelfEKSgamtggsrAPRGGILFSRS 671

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1108 LLQKQPVPLEQVEALKKSLNG------TIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLKLK-EALEK 1180
Cdd:TIGR02169  672 EPAELQRLRERLEGLKRELSSlqselrRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDlSSLEQ 751

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1181 EVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVD-MSKYKATKNDLETQISNLNDKLASLNRKYDQA 1259
Cdd:TIGR02169  752 EIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAeLSKLEEEVSRIEARLREIEQKLNRLTLEKEYL 831

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1260 CEEKVSAKDEKELLhlsiEQEIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYS 1339
Cdd:TIGR02169  832 EKEIQELQEQRIDL----KEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEE 907

                          810       820       830
                   ....*....|....*....|....*....|....*....
gi 1270530344 1340 SGSPTKRQSQLVDTLQQRVRDLQQQLADADRQHQEVIAI 1378
Cdd:TIGR02169  908 LEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEI 946
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 70-224 3.61e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 61.05  E-value: 3.61e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   70 GRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHdAAMADCP 149
Cdd:PHA02878   168 GNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLH-ISVGYCK 246

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1270530344  150 SS--IQLLCDHGASVNAKD-IDGRTPLVLATQmcRPTICQLLIDRGADVNSRDKQNRTAL-MLGCEYGCRDAVEVLVKN 224
Cdd:PHA02878   247 DYdiLKLLLEHGVDVNAKSyILGLTALHSSIK--SERKLKLLLEYGADINSLNSYKLTPLsSAVKQYLCINIGRILISN 323
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 687-1364 3.92e-09

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 61.52  E-value: 3.92e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  687 EEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDveklhadnklLNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDL 766
Cdd:TIGR00618  176 DQYTQLALMEFAKKKSLHGKAELLTLRSQLLTLC----------TPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYL 245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  767 NKKLSEATQRyTEKKQEAERLLAENDKLTKNVSRLEAvfvapEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRAL 846
Cdd:TIGR00618  246 TQKREAQEEQ-LKKQQLLKQLRARIEELRAQEAVLEE-----TQERINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSK 319

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  847 MSENSSLKKTLSSQYVPAKTHEEVKASLNStvektnraLLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQnQMKADYVS 926
Cdd:TIGR00618  320 MRSRAKLLMKRAAHVKQQSSIEEQRRLLQT--------LHSQEIHIRDAHEVATSIREISCQQHTLTQHIH-TLQQQKTT 390

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  927 LEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKY----APLARLEECERKFKA 1002
Cdd:TIGR00618  391 LTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAqcekLEKIHLQESAQSLKE 470

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1003 TEKGL--KEQLSEQTHKCRQRDEEVKKGKQENER--------------LRADLAALQKELQDRNALAEEAREAERALSGK 1066
Cdd:TIGR00618  471 REQQLqtKEQIHLQETRKKAVVLARLLELQEEPCplcgscihpnparqDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQ 550

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1067 ADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELR---SKQRC 1143
Cdd:TIGR00618  551 LTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQpeqDLQDV 630

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1144 LEREQQTVSQLQQLLENQKNSSVTLA-----EHLKLKEALEKEVGimkASLREKEEESQKKTKEVSKLQTEVQTTKQALK 1218
Cdd:TIGR00618  631 RLHLQQCSQELALKLTALHALQLTLTqervrEHALSIRVLPKELL---ASRQLALQKMQSEKEQLTYWKEMLAQCQTLLR 707

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1219 NLET------REVVDMSKYKAT-KNDLETQISNLNDKLASLNRKYDQACEEKVSA---KDEKELLHLSIEQEIRDQKERC 1288
Cdd:TIGR00618  708 ELEThieeydREFNEIENASSSlGSDLAAREDALNQSLKELMHQARTVLKARTEAhfnNNEEVTAALQTGAELSHLAAEI 787

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1289 DKSLTTIMELQQRIQESAKQIEAK-----DNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDLQQ 1363
Cdd:TIGR00618  788 QFFNRLREEDTHLLKTLEAEIGQEipsdeDILNLQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQE 867


                   .
gi 1270530344 1364 Q 1364
Cdd:TIGR00618  868 Q 868
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 306-1165 4.03e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 61.62  E-value: 4.03e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  306 IENEDLREKLRKIqqEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDH 385
Cdd:TIGR02169  211 ERYQALLKEKREY--EGYELLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEE 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  386 pgpgsypSNR-KEDMLHKQGQMYTTEPQCASpgipphmhsrSMLRPLELSLPSQTSYSENEILKKELETLRTYYDSAKQD 464
Cdd:TIGR02169  289 -------QLRvKEKIGELEAEIASLERSIAE----------KERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKR 351

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  465 RLKFQNELAHKVAECKALALECERVKEDSDE---QIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTNeaatgSH 541
Cdd:TIGR02169  352 RDKLTEEYAELKEELEDLRAELEEVDKEFAEtrdELKDYREKLEKLKREINELKRELDRLQEELQRLSEELAD-----LN 426

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  542 RIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERrgrrvveLEGQL 621
Cdd:TIGR02169  427 AAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAE-------AEAQA 499

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  622 KELGAKLALSVPTEKfesMKSSLSNDINEKVKRLAEVGRDY----ESAQG-EIRQLKRDLESVRAQHIrpeehEQLRSRl 696
Cdd:TIGR02169  500 RASEERVRGGRAVEE---VLKASIQGVHGTVAQLGSVGERYataiEVAAGnRLNNVVVEDDAVAKEAI-----ELLKRR- 570

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  697 eqksgelgkKVSELTL----KNQTLQKDVEKLHADNKL---LNqqvhslTVEMKTRYVP---------LRVS------EE 754
Cdd:TIGR02169  571 ---------KAGRATFlplnKMRDERRDLSILSEDGVIgfaVD------LVEFDPKYEPafkyvfgdtLVVEdieaarRL 635

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  755 MKKSHDVNVE-DLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVfvapekhEKELMGLKSNIAELKKQLSELN 833
Cdd:TIGR02169  636 MGKYRMVTLEgELFEKSGAMTGGSRAPRGGILFSRSEPAELQRLRERLEGL-------KRELSSLQSELRRIENRLDELS 708

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  834 KKCGEGQEKIRALMSENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDE-NEVLRRN 912
Cdd:TIGR02169  709 QELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEAlNDLEARL 788

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  913 LENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKlkyaplAR 992
Cdd:TIGR02169  789 SHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLN------GK 862

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  993 LEECERKFKATEKGLkeqlseqthkcRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSK 1072
Cdd:TIGR02169  863 KEELEEELEELEAAL-----------RDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEE 931

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1073 QLKDLsqkysdvkserEKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKE------ELRSKQRCLER 1146
Cdd:TIGR02169  932 ELSEI-----------EDPKGEDEEIPEEELSLEDVQAELQRVEEEIRALEPVNMLAIQEYEEvlkrldELKEKRAKLEE 1000

                          890
                   ....*....|....*....
gi 1270530344 1147 EQQTVSQLQQLLENQKNSS 1165
Cdd:TIGR02169 1001 ERKAILERIEEYEKKKREV 1019
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 651-1334 2.48e-08

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 58.70  E-value: 2.48e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  651 KVKRLAEVGRDYESAQGEIRQLKR-----DLESVRAQHIRPEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLH 725
Cdd:pfam12128  242 EFTKLQQEFNTLESAELRLSHLHFgyksdETLIASRQEERQETSAELNQLLRTLDDQWKEKRDELNGELSAADAAVAKDR 321

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  726 ADNKLLNQQvhsLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNK--KLSEATQRYTEKKQEAERLLAE---NDKLTKNVSR 800
Cdd:pfam12128  322 SELEALEDQ---HGAFLDADIETAAADQEQLPSWQSELENLEErlKALTGKHQDVTAKYNRRRSKIKeqnNRDIAGIKDK 398

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  801 LEAVFVAPEK-HEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSEnssLKKTLSSqyvpAKTHEEVKASLNSTVE 879
Cdd:pfam12128  399 LAKIREARDRqLAVAEDDLQALESELREQLEAGKLEFNEEEYRLKSRLGE---LKLRLNQ----ATATPELLLQLENFDE 471

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  880 KTNRALLEAKKRFddtsQEVSKLRDENEVLRRNLENVQnqmkadyVSLEEHSRRMSTVSQSLKEAQEanaailadhrQGQ 959
Cdd:pfam12128  472 RIERAREEQEAAN----AEVERLQSELRQARKRRDQAS-------EALRQASRRLEERQSALDELEL----------QLF 530

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  960 EEIVSLHAEIKaqkKELDTIQECIKlKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADL 1039
Cdd:pfam12128  531 PQAGTLLHFLR---KEAPDWEQSIG-KVISPELLHRTDLDPEVWDGSVGGELNLYGVKLDLKRIDVPEWAASEEELRERL 606

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1040 AALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVP-LEQ 1118
Cdd:pfam12128  607 DKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTALKNARLDLRRLFDEKQSEKDKKNKALAERKDSANErLNS 686

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1119 VEALKKSLNGTIEQLKEELRSKQRCLEREQQtvsqlQQLLENQKNSSVTLAehlKLKEALEKEVGIMKASLREKEEESQK 1198
Cdd:pfam12128  687 LEAQLKQLDKKHQAWLEEQKEQKREARTEKQ-----AYWQVVEGALDAQLA---LLKAAIAARRSGAKAELKALETWYKR 758

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1199 KTKE-------VSKLQTEVQTTKQALKNLETRE--------------VVDMSKYKATKNDLETQISNLNDKLASLnrkyd 1257
Cdd:pfam12128  759 DLASlgvdpdvIAKLKREIRTLERKIERIAVRRqevlryfdwyqetwLQRRPRLATQLSNIERAISELQQQLARL----- 833

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1270530344 1258 QACEEKVSAKDEKELlhlsieQEIRDQKERCDKSLTTIMELQQRIQE--SAKQIEAKDNKITELLNDVERLKQALNGLS 1334
Cdd:pfam12128  834 IADTKLRRAKLEMER------KASEKQQVRLSENLRGLRCEMSKLATlkEDANSEQAQGSIGERLAQLEDLKLKRDYLS 906
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 444-1294 2.53e-08

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 58.91  E-value: 2.53e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  444 NEILKKELETLRTYYDSAKQDRLKFQNELAHKVAEckalalecervkedsdeqikqLEDALKDVQKRMYESegKVKQMQT 523
Cdd:TIGR01612  944 KEILNKNIDTIKESNLIEKSYKDKFDNTLIDKINE---------------------LDKAFKDASLNDYEA--KNNELIK 1000

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  524 HFLALKEHLTNEAATGSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQS-EMLVGEFKRDEGRLVEE-NKRLQKECG 601
Cdd:TIGR01612 1001 YFNDLKANLGKNKENMLYHQFDEKEKATNDIEQKIEDANKNIPNIEIAIHTSiYNIIDEIEKEIGKNIELlNKEILEEAE 1080

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  602 TCEVELE--RRGRRVVELEGQLKELGAKLALSVptEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESV 679
Cdd:TIGR01612 1081 INITNFNeiKEKLKHYNFDDFGKEENIKYADEI--NKIKDDIKNLDQKIDHHIKALEEIKKKSENYIDEIKAQINDLEDV 1158

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  680 RAQHIRPEEHEQLRSRLEQKSGELGKK------VSELTLKNQTLQKD---VEKLHADNKLLNQQVHSLTVEMKTRyvPLR 750
Cdd:TIGR01612 1159 ADKAISNDDPEEIEKKIENIVTKIDKKkniydeIKKLLNEIAEIEKDktsLEEVKGINLSYGKNLGKLFLEKIDE--EKK 1236

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  751 VSEEMKKSHDVNVEDLNkKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELmglkSNIAELKKQLS 830
Cdd:TIGR01612 1237 KSEHMIKAMEAYIEDLD-EIKEKSPEIENEMGIEMDIKAEMETFNISHDDDKDHHIISKKHDENI----SDIREKSLKII 1311

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  831 ELNKKcgegqekiralMSENSSLKKTLSSQYVPAKTH-EEVKASLNSTVEKTN-RALLEAKKRFDDTSQEVSKLRDENEV 908
Cdd:TIGR01612 1312 EDFSE-----------ESDINDIKKELQKNLLDAQKHnSDINLYLNEIANIYNiLKLNKIKKIIDEVKEYTKEIEENNKN 1380

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  909 LRRNLENVQNQMKA--DYVSLEE-HSRRMSTVSQSLKEAQEANAAILADHrqgqeeIVSLHAEIKAQKKELDTIQECIKL 985
Cdd:TIGR01612 1381 IKDELDKSEKLIKKikDDINLEEcKSKIESTLDDKDIDECIKKIKELKNH------ILSEESNIDTYFKNADENNENVLL 1454

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  986 KYaplarlEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLradlaalqKELQDRNALAEEareaeralsg 1065
Cdd:TIGR01612 1455 LF------KNIEMADNKSQHILKIKKDNATNDHDFNINELKEHIDKSKGC--------KDEADKNAKAIE---------- 1510

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1066 KADELSKQLK----DLSQKYSDVKSEREKlveEKAKQASEILAAQNLLQKQPVPLEQvealkkslnGTIEQLKEELRSKQ 1141
Cdd:TIGR01612 1511 KNKELFEQYKkdvtELLNKYSALAIKNKF---AKTKKDSEIIIKEIKDAHKKFILEA---------EKSEQKIKEIKKEK 1578

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1142 RCLERE-------QQTVSQLQQLLENQKNSSVTLA-------EHLKLKEALEKEVGIMkaSLREKEEESQKKTKEVSKLQ 1207
Cdd:TIGR01612 1579 FRIEDDaakndksNKAAIDIQLSLENFENKFLKISdikkkinDCLKETESIEKKISSF--SIDSQDTELKENGDNLNSLQ 1656

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1208 TEVQTTKQALKNLETRevvdmskyKATKNDLETQISNLNDKLASLNRKYDQACEEKVS--AKDEKELLHlSIEQEIRDQK 1285
Cdd:TIGR01612 1657 EFLESLKDQKKNIEDK--------KKELDELDSEIEKIEIDVDQHKKNYEIGIIEKIKeiAIANKEEIE-SIKELIEPTI 1727


                   ....*....
gi 1270530344 1286 ERCDKSLTT 1294
Cdd:TIGR01612 1728 ENLISSFNT 1736
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 496-1093 3.23e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 58.41  E-value: 3.23e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  496 QIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTNEAATgshriIEELREQLKDLKGKYEGASAEVGKLRSQIKQS 575
Cdd:COG1196    233 KLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE-----LEELELELEEAQAEEYELLAELARLEQDIARL 307

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  576 EMLVGEFKRDEGRLVEENKRLQKECGTCEVELERRGRRVVELEGQLKELGAKLalsvptEKFESMKSSLSNDINEKVKRL 655
Cdd:COG1196    308 EERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAEL------AEAEEALLEAEAELAEAEEEL 381

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  656 AEVGRDYESAQGEIRQLKRDLESVRAQHirpEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQV 735
Cdd:COG1196    382 EELAEELLEALRAAAELAAQLEELEEAE---EALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEE 458

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  736 HSLTVEMKTRYVPLRVSEEmkkshdvNVEDLNKKLSEATQRYTEKKQEAE------------RLLAENDKLTKNVSRLEA 803
Cdd:COG1196    459 EALLELLAELLEEAALLEA-------ALAELLEELAEAAARLLLLLEAEAdyegflegvkaaLLLAGLRGLAGAVAVLIG 531

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  804 VFVAPEKHEKELMGlkSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNR 883
Cdd:COG1196    532 VEAAYEAALEAALA--AALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLR 609

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  884 ALLEAKKRFDDTSQevsklrdENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIV 963
Cdd:COG1196    610 EADARYYVLGDTLL-------GRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELE 682

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  964 SLHAEIKAQKKELDTIQEciklkyaplaRLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQ 1043
Cdd:COG1196    683 ELAERLAEEELELEEALL----------AEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEA 752

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1270530344 1044 KELQDRNALAEEAREAERALSGK--------------ADELSKQLKDLSQKYSDVKSEREKLVE 1093
Cdd:COG1196    753 LEELPEPPDLEELERELERLEREiealgpvnllaieeYEELEERYDFLSEQREDLEEARETLEE 816
Ank_4 pfam13637
Ankyrin repeats (many copies);
70-123 3.45e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.12  E-value: 3.45e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1270530344   70 GRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLL 123
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
136-189 3.70e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.12  E-value: 3.70e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1270530344  136 GRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLI 189
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 152-249 3.94e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 57.99  E-value: 3.94e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  152 IQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLL 231
Cdd:PTZ00322    98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFEL 177

                           90
                   ....*....|....*...
gi 1270530344  232 DALGHDSSYYARIGDNLD 249
Cdd:PTZ00322   178 GANAKPDSFTGKPPSLED 195
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 83-262 4.05e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 57.31  E-value: 4.05e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   83 LECLNAILTHGIDVATR--DSA---------GRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSS 151
Cdd:PHA02875     4 VALCDAILFGELDIARRllDIGinpnfeiydGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKA 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  152 IQLLCDHGASVNakDI---DGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADL 228
Cdd:PHA02875    84 VEELLDLGKFAD--DVfykDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACL 161

                          170       180       190
                   ....*....|....*....|....*....|....
gi 1270530344  229 TLLDALGHDSSYYARIGDNLDILNLLKTASENTN 262
Cdd:PHA02875   162 DIEDCCGCTPLIIAMAKGDIAICKMLLDSGANID 195
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 445-724 5.33e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 57.76  E-value: 5.33e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  445 EILKKELETLRTYYDSAKQDRLKFQNE---LAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQM 521
Cdd:TIGR02168  736 ARLEAEVEQLEERIAQLSKELTELEAEieeLEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLL 815

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  522 QTHFLALKEHLTNEAATGS--HRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKE 599
Cdd:TIGR02168  816 NEEAANLRERLESLERRIAatERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSE 895

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  600 CGTCEVELERRGRRVVELEGQLKELGAKLAlsvpteKFESMKSSLSNDINEKVKRLAEVGRD--------YESAQGEIRQ 671
Cdd:TIGR02168  896 LEELSEELRELESKRSELRRELEELREKLA------QLELRLEGLEVRIDNLQERLSEEYSLtleeaealENKIEDDEEE 969

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1270530344  672 LKRDLESVRAQHIR--------PEEHEQLRSRLEqksgELGKKVSELTLKNQTLQKDVEKL 724
Cdd:TIGR02168  970 ARRRLKRLENKIKElgpvnlaaIEEYEELKERYD----FLTAQKEDLTEAKETLEEAIEEI 1026
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 22-236 8.69e-08

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 57.01  E-value: 8.69e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   22 PTAVASTQSAEWNKYDDRLMKAAERGDVEKVSsilaKKGVHPGKLDVE-----GRSAFHVVASKGNLECLNAIL-THGID 95
Cdd:TIGR00870    3 PLDIVPAEESPLSDEEKAFLPAAERGDLASVY----RDLEEPKKLNINcpdrlGRSALFVAAIENENLELTELLlNLSCR 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   96 VATrdsaGRNALHLAAKYGHA---LCLQKLLQ---YNCPTEHVDLQ-------GRTALHDAAMADCPSSIQLLCDHGASV 162
Cdd:TIGR00870   79 GAV----GDTLLHAISLEYVDaveAILLHLLAafrKSGPLELANDQytseftpGITALHLAAHRQNYEIVKLLLERGASV 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  163 NAK----------DID----GRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALML-------GCEY--------- 212
Cdd:TIGR00870  155 PARacgdffvksqGVDsfyhGESPLNAAACLGSPSIVALLSEDPADILTADSLGNTLLHLlvmenefKAEYeelscqmyn 234

                          250       260       270
                   ....*....|....*....|....*....|..
gi 1270530344  213 -------GCRDAVEV-LVKNGADLTLLDALGH 236
Cdd:TIGR00870  235 falslldKLRDSKELeVILNHQGLTPLKLAAK 266
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
495-710 1.45e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 56.46  E-value: 1.45e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  495 EQIKQLEDALKDVQK--RMYESEGKVKQMQTHFLALKEHLTNEAATgshRIIEELREQLKDLKGKYEGASAEVGKLRSQI 572
Cdd:COG4913    249 EQIELLEPIRELAERyaAARERLAELEYLRAALRLWFAQRRLELLE---AELEELRAELARLEAELERLEARLDALREEL 325

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  573 kqsEMLVGEFKRDEGRLVEenkRLQKECGTCEVELERRGRRVVELEGQLKELGAKLALSVPT-----EKFESMKSSLSND 647
Cdd:COG4913    326 ---DELEAQIRGNGGDRLE---QLEREIERLERELEERERRRARLEALLAALGLPLPASAEEfaalrAEAAALLEALEEE 399

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1270530344  648 INEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIR-PEEHEQLRSRLEQksgELGKKVSEL 710
Cdd:COG4913    400 LEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNiPARLLALRDALAE---ALGLDEAEL 460
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 962-1374 1.46e-07

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 56.18  E-value: 1.46e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  962 IVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAA 1041
Cdd:TIGR04523   28 ANKQDTEEKQLEKKLKTIKNELKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSK 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1042 LQKELQDRNalaeeareaeralsgkadelsKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEA 1121
Cdd:TIGR04523  108 INSEIKNDK---------------------EQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKK 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1122 LKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTK 1201
Cdd:TIGR04523  167 QKEELENELNLLEKEKLNIQKNIDKIKNKLLKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTT 246

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1202 EVSKLQTEVQTTKQALKNLETR---EVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKV-----SAKDEKELL 1273
Cdd:TIGR04523  247 EISNTQTQLNQLKDEQNKIKKQlseKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQDWNKELkselkNQEKKLEEI 326

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1274 HLSI---EQEIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQL 1350
Cdd:TIGR04523  327 QNQIsqnNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKL 406

                          410       420
                   ....*....|....*....|....
gi 1270530344 1351 VDTLQQRVRDLQQQLADADRQHQE 1374
Cdd:TIGR04523  407 NQQKDEQIKKLQQEKELLEKEIER 430
PRK01156 PRK01156
chromosome segregation protein; Provisional
 640-1229 3.49e-07

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 54.91  E-value: 3.49e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  640 MKSSLSNDINEKVKRLAEVgRDYESAQGEIRQLKRDLESVRAQhirPEEHEQLRSRLEQKSGEL---GKKVSELTLKNQT 716
Cdd:PRK01156   140 MDSLISGDPAQRKKILDEI-LEINSLERNYDKLKDVIDMLRAE---ISNIDYLEEKLKSSNLELeniKKQIADDEKSHSI 215

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  717 LQKDVEKLHADNKLLNQQVHSLTVEMKTryvpLRVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAERLLA-ENDKLT 795
Cdd:PRK01156   216 TLKEIERLSIEYNNAMDDYNNLKSALNE----LSSLEDMKNRYESEIKTAESDLSMELEKNNYYKELEERHMKiINDPVY 291

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  796 KNVSRLEAVFvapeKHEKELMGLKSNIAELKKQLS--ELNKKCGEGQEKIRALMSENSSLKKTLSSQYVPAKTHEEVKAS 873
Cdd:PRK01156   292 KNRNYINDYF----KYKNDIENKKQILSNIDAEINkyHAIIKKLSVLQKDYNDYIKKKSRYDDLNNQILELEGYEMDYNS 367

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  874 LNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKadyVSLEEHSRRMSTVSQSL------KEAQEA 947
Cdd:PRK01156   368 YLKSIESLKKKIEEYSKNIERMSAFISEILKIQEIDPDAIKKELNEIN---VKLQDISSKVSSLNQRIralrenLDELSR 444

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  948 NAAILADH-----------RQGQEEIVS--------LHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLK 1008
Cdd:PRK01156   445 NMEMLNGQsvcpvcgttlgEEKSNHIINhynekksrLEEKIREIEIEVKDIDEKIVDLKKRKEYLESEEINKSINEYNKI 524

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1009 EQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDR------NALAEEAREAERALSGKADELSKQLKDLSQKYS 1082
Cdd:PRK01156   525 ESARADLEDIKIKINELKDKHDKYEEIKNRYKSLKLEDLDSkrtswlNALAVISLIDIETNRSRSNEIKKQLNDLESRLQ 604

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1083 DVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQK 1162
Cdd:PRK01156   605 EIEIGFPDDKSYIDKSIREIENEANNLNNKYNEIQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLK 684

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1270530344 1163 NSSVTLAEHLKLKEALEKEVGImkasLREKEEESQKKTKEVSKLQTEVQTTKQALKNL-ETREVVDMS 1229
Cdd:PRK01156   685 KSRKALDDAKANRARLESTIEI----LRTRINELSDRINDINETLESMKKIKKAIGDLkRLREAFDKS 748
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 78-206 4.82e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 54.25  E-value: 4.82e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   78 ASKGNLECLNAILT-HGIDVATRDSAGRNALHLAAKYGHALCLQKLLqyNCPTEHVDL-------QGRTALHDAAMADCP 149
Cdd:cd22192     25 AKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLM--EAAPELVNEpmtsdlyQGETALHIAVVNQNL 102

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1270530344  150 SSIQLLCDHGASVNA---------KDID-----GRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTAL 206
Cdd:cd22192    103 NLVRELIARGADVVSpratgtffrPGPKnliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
PRK01156 PRK01156
chromosome segregation protein; Provisional
 878-1369 1.14e-06

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 53.37  E-value: 1.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  878 VEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKadyvSLEEHSRRMSTVSQSLKEAQEANAAILADHRQ 957
Cdd:PRK01156   161 INSLERNYDKLKDVIDMLRAEISNIDYLEEKLKSSNLELENIKK----QIADDEKSHSITLKEIERLSIEYNNAMDDYNN 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  958 GQEEIvslhAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRA 1037
Cdd:PRK01156   237 LKSAL----NELSSLEDMKNRYESEIKTAESDLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENKKQ 312

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1038 DLAALQKELQDRNALAEEAREAERALS------GKADELSKQLKDLSQKYSD-------VKSEREKLVEEKAKQASEILA 1104
Cdd:PRK01156   313 ILSNIDAEINKYHAIIKKLSVLQKDYNdyikkkSRYDDLNNQILELEGYEMDynsylksIESLKKKIEEYSKNIERMSAF 392

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1105 AQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRS---KQRCLEREQQTVSQLQQLLENQKNSSVTlAEHLKlKEALEKE 1181
Cdd:PRK01156   393 ISEILKIQEIDPDAIKKELNEINVKLQDISSKVSSlnqRIRALRENLDELSRNMEMLNGQSVCPVC-GTTLG-EEKSNHI 470

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1182 VGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACE 1261
Cdd:PRK01156   471 INHYNEKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEYLESEEINKSINEYNKIESARADLEDIKIKINELKDKHDKYEE 550

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1262 ekvsAKDEKELLHLSIEQEIRDQ--KERCDKSLTTIMELQQRIQESAKQI---EAKDNKITELLNDVERLKQALNGLSQL 1336
Cdd:PRK01156   551 ----IKNRYKSLKLEDLDSKRTSwlNALAVISLIDIETNRSRSNEIKKQLndlESRLQEIEIGFPDDKSYIDKSIREIEN 626

                          490       500       510
                   ....*....|....*....|....*....|....*..
gi 1270530344 1337 TYSSGSPTKRQSQ----LVDTLQQRVRDLQQQLADAD 1369
Cdd:PRK01156   627 EANNLNNKYNEIQenkiLIEKLRGKIDNYKKQIAEID 663
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
939-1401 1.19e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 53.23  E-value: 1.19e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  939 QSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLkYAPLARLEECERKFKATEKGLkEQLSEQTHKC 1018
Cdd:COG4717     81 KEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQL-LPLYQELEALEAELAELPERL-EELEERLEEL 158

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1019 RQRDEEVKKGKQENERLRADLAALQKELQDRNALA-EEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAK 1097
Cdd:COG4717    159 RELEEELEELEAELAELQEELEELLEQLSLATEEElQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEA 238

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1098 Q---------------ASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQK 1162
Cdd:COG4717    239 AaleerlkearlllliAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEE 318

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1163 NSSVTLAEHLKLKEALEKEvgiMKASLREKEEESQKKTKEVSKLQTEVQttkqaLKNLETREVVDMSKYKAtkndletqi 1242
Cdd:COG4717    319 EELEELLAALGLPPDLSPE---ELLELLDRIEELQELLREAEELEEELQ-----LEELEQEIAALLAEAGV--------- 381

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1243 snlnDKLASLNRKYDQAcEEKVSAKDEKELLHLSIEQEIRDQKERCDKSLTTimELQQRIQESAKQIEAKDNKITELLND 1322
Cdd:COG4717    382 ----EDEEELRAALEQA-EEYQELKEELEELEEQLEELLGELEELLEALDEE--ELEEELEELEEELEELEEELEELREE 454

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1270530344 1323 VERLKQALNGLsqltyssgsptkRQSQLVDTLQQRVRDLQQQLADADRQHQEVIAIYrtHLLSAAQGHMDEDVQAALLQ 1401
Cdd:COG4717    455 LAELEAELEQL------------EEDGELAELLQELEELKAELRELAEEWAALKLAL--ELLEEAREEYREERLPPVLE 519
46 PHA02562
endonuclease subunit; Provisional
 494-725 1.41e-06

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 52.71  E-value: 1.41e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  494 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTNEAATgSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIK 573
Cdd:PHA02562   187 DMKIDHIQQQIKTYNKNIEEQRKKNGENIARKQNKYDELVEEAKT-IKAEIEELTDELLNLVMDIEDPSAALNKLNTAAA 265

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  574 QSEMLVGEFKRDEgRLVEENkrlqKECGTCEVELERRGRRVVELEGQLKELGAKLALSvpTEKFESMKsSLSNDINEKVK 653
Cdd:PHA02562   266 KIKSKIEQFQKVI-KMYEKG----GVCPTCTQQISEGPDRITKIKDKLKELQHSLEKL--DTAIDELE-EIMDEFNEQSK 337

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1270530344  654 RLAEVgrdyesaQGEIRQLKRDLESVRAQHIRPE-EHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLH 725
Cdd:PHA02562   338 KLLEL-------KNKISTNKQSLITLVDKAKKVKaAIEELQAEFVDNAEELAKLQDELDKIVKTKSELVKEKY 403
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 884-1105 1.41e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 52.07  E-value: 1.41e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  884 ALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIV 963
Cdd:COG4942     14 AAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIA 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  964 SLHAEIKAQKKEL-DTIQECIKLKYAPLARL----EECERKFKATE--KGLKEQLSEQTHKCRQRDEEVKKGKQENERLR 1036
Cdd:COG4942     94 ELRAELEAQKEELaELLRALYRLGRQPPLALllspEDFLDAVRRLQylKYLAPARREQAEELRADLAELAALRAELEAER 173

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1270530344 1037 ADLAALQKELQDR----NALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAA 1105
Cdd:COG4942    174 AELEALLAELEEEraalEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAA 246
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 644-1271 1.42e-06

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 52.80  E-value: 1.42e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  644 LSNDINEKVKRLAEVGRDYESAQGEIR-QLKRDLESVraQHIRPEEHEQLRSRLEQ------KSGELGKKVSELTLKNQT 716
Cdd:pfam05483  188 LNNNIEKMILAFEELRVQAENARLEMHfKLKEDHEKI--QHLEEEYKKEINDKEKQvsllliQITEKENKMKDLTFLLEE 265

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  717 LQKDVEKLHADNKL-------LNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQrytEKKQEAERLLA 789
Cdd:pfam05483  266 SRDKANQLEEKTKLqdenlkeLIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQIATKTICQLTE---EKEAQMEELNK 342

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  790 ENDKLTKNVSRLEAVFVAPEKHEK-ELMGLKSNIAELKKQLSELNKKCGEGQEKIRAlmsensslkktlssqyvpaKTHE 868
Cdd:pfam05483  343 AKAAHSFVVTEFEATTCSLEELLRtEQQRLEKNEDQLKIITMELQKKSSELEEMTKF-------------------KNNK 403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  869 EVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVL----RRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEA 944
Cdd:pfam05483  404 EVELEELKKILAEDEKLLDEKKQFEKIAEELKGKEQELIFLlqarEKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKE 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  945 QEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEE 1024
Cdd:pfam05483  484 KLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDE 563

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1025 VK--KGKQENERLRADLAALQKELQDRnalaeeareaerALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEI 1102
Cdd:pfam05483  564 VKckLDKSEENARSIEYEVLKKEKQMK------------ILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQL 631

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1103 LAAQnllqkqpvplEQVEALKKSLNGTIEQLKEELRSKQRclEREQQTVSQlQQLLENQKNSSVTLAEHLKLKEALEKEV 1182
Cdd:pfam05483  632 NAYE----------IKVNKLELELASAKQKFEEIIDNYQK--EIEDKKISE-EKLLEEVEKAKAIADEAVKLQKEIDKRC 698

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1183 gimKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREvvdmskyKATKNDLETQISNLNDKLASLNRKYDQACEE 1262
Cdd:pfam05483  699 ---QHKIAEMVALMEKHKHQYDKIIEERDSELGLYKNKEQEQ-------SSAKAALEIELSNIKAELLSLKKQLEIEKEE 768


                   ....*....
gi 1270530344 1263 KVSAKDEKE 1271
Cdd:pfam05483  769 KEKLKMEAK 777
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 780-1375 1.58e-06

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 52.92  E-value: 1.58e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  780 KKQEAERLLAEND------KLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRA-LMSENSS 852
Cdd:pfam12128  219 NRQQVEHWIRDIQaiagimKIRPEFTKLQQEFNTLESAELRLSHLHFGYKSDETLIASRQEERQETSAELNQlLRTLDDQ 298

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  853 LKKTLSSQYVPAKTHEEVKASLNSTVEktnrALLEAKKRFDDTSQEVSKLRDENEVLRRN-LENVQNQMKAdyvsLEEHS 931
Cdd:pfam12128  299 WKEKRDELNGELSAADAAVAKDRSELE----ALEDQHGAFLDADIETAAADQEQLPSWQSeLENLEERLKA----LTGKH 370

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  932 RRMSTVSQSLKEA-QEANAAILADHRQGQ----EEIVSLHAEIKAQKKELDtiQECIKLKYAPLARLEECERKFKATEKG 1006
Cdd:pfam12128  371 QDVTAKYNRRRSKiKEQNNRDIAGIKDKLakirEARDRQLAVAEDDLQALE--SELREQLEAGKLEFNEEEYRLKSRLGE 448

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1007 LKEQL------SEQTHKCRQRDEEVKKGKQENERLRADLAALQKELqdrnalaeeareaeRALSGKADELSKQLKDLSQK 1080
Cdd:pfam12128  449 LKLRLnqatatPELLLQLENFDERIERAREEQEAANAEVERLQSEL--------------RQARKRRDQASEALRQASRR 514

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1081 YSDVKSEREKLVEEKAKQASEILAaqnLLQKQPVPLEQVEA--LKKSLNGTIEqLKEELRSKQRCLEREQQTVS-QLQQL 1157
Cdd:pfam12128  515 LEERQSALDELELQLFPQAGTLLH---FLRKEAPDWEQSIGkvISPELLHRTD-LDPEVWDGSVGGELNLYGVKlDLKRI 590

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1158 lenQKNSSVTLAEHLKLK-EALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVvdmskykatkn 1236
Cdd:pfam12128  591 ---DVPEWAASEEELRERlDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTALKNARLDLR----------- 656

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1237 DLETQISNLNDKLA-SLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKErcdKSLTTIMELQQRIQESakqIEAKDNK 1315
Cdd:pfam12128  657 RLFDEKQSEKDKKNkALAERKDSANERLNSLEAQLKQLDKKHQAWLEEQKE---QKREARTEKQAYWQVV---EGALDAQ 730

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1270530344 1316 I----TELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDLQQQLADADRQHQEV 1375
Cdd:pfam12128  731 LallkAAIAARRSGAKAELKALETWYKRDLASLGVDPDVIAKLKREIRTLERKIERIAVRRQEV 794
PHA02798 PHA02798
ankyrin-like protein; Provisional
 152-255 1.64e-06

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 52.53  E-value: 1.64e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  152 IQLLCDHGASVNAKDIDGRTPL--VLATQMCRPT---ICQLLIDRGADVNSRDKQNRTAL--MLGCEY-GCRDAVEVLVK 223
Cdd:PHA02798    54 VKLFINLGANVNGLDNEYSTPLctILSNIKDYKHmldIVKILIENGADINKKNSDGETPLycLLSNGYiNNLEILLFMIE 133

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1270530344  224 NGADLTLLDALGHDS-SYYARIGDNLDIlNLLK 255
Cdd:PHA02798   134 NGADTTLLDKDGFTMlQVYLQSNHHIDI-EIIK 165
Ank_2 pfam12796
Ankyrin repeats (3 copies);
173-254 1.78e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.42  E-value: 1.78e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  173 LVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGAdltlLDALGHDSS--YYARIGDNLDI 250
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD----VNLKDNGRTalHYAARSGHLEI 76


                   ....
gi 1270530344  251 LNLL 254
Cdd:pfam12796   77 VKLL 80
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
494-685 1.90e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 52.61  E-value: 1.90e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  494 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLA---LKEHLTNEAATGS-HRIIEELREQLKDLK---GKYEGASAEVG 566
Cdd:COG4913    616 EAELAELEEELAEAEERLEALEAELDALQERREAlqrLAEYSWDEIDVASaEREIAELEAELERLDassDDLAALEEQLE 695

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  567 KLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERRGRRVVelEGQLKELGAKLALSVPTEKFESMKSSLSN 646
Cdd:COG4913    696 ELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLAR--LELRALLEERFAAALGDAVERELRENLEE 773

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1270530344  647 DInekvkrlaevgrdyESAQGEIRQLKRDLESVRAQHIR 685
Cdd:COG4913    774 RI--------------DALRARLNRAEEELERAMRAFNR 798
PRK01156 PRK01156
chromosome segregation protein; Provisional
 792-1370 2.05e-06

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 52.60  E-value: 2.05e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  792 DKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSSqyvpAKTHEEVK 871
Cdd:PRK01156   176 DMLRAEISNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNE----LSSLEDMK 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  872 ASLNSTVEKTNRAL---LEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEAN 948
Cdd:PRK01156   252 NRYESEIKTAESDLsmeLEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENKKQILSNIDAEINKYHAIIKKL 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  949 AAILADHRQgQEEIVSLHAEIKAQKKELDTIQEciklKYAPLArleeceRKFKATEKGLKEQLSEQTHKCRQRDEEVKKG 1028
Cdd:PRK01156   332 SVLQKDYND-YIKKKSRYDDLNNQILELEGYEM----DYNSYL------KSIESLKKKIEEYSKNIERMSAFISEILKIQ 400

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1029 KQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQK---------YSDVKSER--EKLVEEKAK 1097
Cdd:PRK01156   401 EIDPDAIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEMLNGQsvcpvcgttLGEEKSNHiiNHYNEKKSR 480

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1098 QASEILAAQNLLQKQPVPLEQVEALKKSLNGtieqlkeelrSKQRCLEREQQTVSQLQQLLENQKNSSVTLAE-HLKLKE 1176
Cdd:PRK01156   481 LEEKIREIEIEVKDIDEKIVDLKKRKEYLES----------EEINKSINEYNKIESARADLEDIKIKINELKDkHDKYEE 550

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1177 ALEKEVGIMKASLREKEEE-----SQKKTKEVSKLQTEVQTTKQALKNLETREVVDMSKYKATKNDLETQISNLNDKLAS 1251
Cdd:PRK01156   551 IKNRYKSLKLEDLDSKRTSwlnalAVISLIDIETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYIDKSIREIENEANN 630

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1252 LNRKYDQAcEEKVSAKDEkellhlsIEQEIRDQKERCDKslttimelQQRIQESAKQIEAKDNKITELLNDVERLKQALN 1331
Cdd:PRK01156   631 LNNKYNEI-QENKILIEK-------LRGKIDNYKKQIAE--------IDSIIPDLKEITSRINDIEDNLKKSRKALDDAK 694

                          570       580       590
                   ....*....|....*....|....*....|....*....
gi 1270530344 1332 glsqltyssgSPTKRQSQLVDTLQQRVRDLQQQLADADR 1370
Cdd:PRK01156   695 ----------ANRARLESTIEILRTRINELSDRINDINE 723
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 668-1328 2.61e-06

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 52.28  E-value: 2.61e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  668 EIRQLKRDLESVRAQHIRPEEHEQLRSRLEQKSGELGKKVSELTLKNQtLQKDVEKLHADNKLLNQQVHSLtveMKTRYV 747
Cdd:pfam02463  184 NLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDY-LKLNEERIDLLQELLRDEQEEI---ESSKQE 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  748 PLRVSEEMKKSHDVNVEDLN-KKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFV--APEKHEKELMGLKSNIAE 824
Cdd:pfam02463  260 IEKEEEKLAQVLKENKEEEKeKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESekEKKKAEKELKKEKEEIEE 339

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  825 LKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRD 904
Cdd:pfam02463  340 LEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLED 419

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  905 ENEVLRRNLENVQNqmkadyvsleehsrrmstVSQSLKEAQEANAAILADHRQGQEEI-VSLHAEIKAQKKELDTIQECI 983
Cdd:pfam02463  420 LLKEEKKEELEILE------------------EEEESIELKQGKLTEEKEELEKQELKlLKDELELKKSEDLLKETQLVK 481

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  984 KLKYapLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERAL 1063
Cdd:pfam02463  482 LQEQ--LELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADE 559

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1064 SGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQA-----SEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELR 1138
Cdd:pfam02463  560 VEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAvleidPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKE 639

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1139 SKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQT--TKQA 1216
Cdd:pfam02463  640 SAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKklKLEA 719

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1217 LKNLETREVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERCDKSLTTIM 1296
Cdd:pfam02463  720 EELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQ 799

                          650       660       670
                   ....*....|....*....|....*....|..
gi 1270530344 1297 ELQQRIQESAKQIEAKDNKITELLNDVERLKQ 1328
Cdd:pfam02463  800 EEELRALEEELKEEAELLEEEQLLIEQEEKIK 831
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1023-1224 2.72e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 51.30  E-value: 2.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1023 EEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEI 1102
Cdd:COG4942     20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1103 LAAQNLLQKQPV---PLEQVEALKKSLNGT-----------IEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNS-SVT 1167
Cdd:COG4942    100 EAQKEELAELLRalyRLGRQPPLALLLSPEdfldavrrlqyLKYLAPARREQAEELRADLAELAALRAELEAERAElEAL 179

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1270530344 1168 LAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETRE 1224
Cdd:COG4942    180 LAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEA 236
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 809-1383 3.04e-06

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 52.03  E-value: 3.04e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  809 EKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSS-------LKKTLSSQYVPAKTHE-------EVKASL 874
Cdd:pfam05483  109 QENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIKENNAtrhlcnlLKETCARSAEKTKKYEyereetrQVYMDL 188

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  875 NSTVEKTNRALLEAKKRFDDTSQEVS-KLRDENEVL-------RRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQE 946
Cdd:pfam05483  189 NNNIEKMILAFEELRVQAENARLEMHfKLKEDHEKIqhleeeyKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRD 268

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  947 ANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKlkyaplarleecerKFKATEKGLKEQLSEQTHKCRQRDEEVK 1026
Cdd:pfam05483  269 KANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQ--------------RSMSTQKALEEDLQIATKTICQLTEEKE 334

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1027 KGKQENERLRADLAALQKELQdrnalaeeareaerALSGKADELskqlkdlsqkysdVKSEREKLveEKAKQASEILAAQ 1106
Cdd:pfam05483  335 AQMEELNKAKAAHSFVVTEFE--------------ATTCSLEEL-------------LRTEQQRL--EKNEDQLKIITME 385

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1107 nlLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKnssvtlaEHLKLKEALEKEVGIMK 1186
Cdd:pfam05483  386 --LQKKSSELEEMTKFKNNKEVELEELKKILAEDEKLLDEKKQFEKIAEELKGKEQ-------ELIFLLQAREKEIHDLE 456

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1187 ASLREKEEESQKKTKEVSKLQTEVQttKQALKNLETREVVDMSKYKATKNDLETQ------------ISNLNDKLASLNR 1254
Cdd:pfam05483  457 IQLTAIKTSEEHYLKEVEDLKTELE--KEKLKNIELTAHCDKLLLENKELTQEASdmtlelkkhqedIINCKKQEERMLK 534

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1255 KYDQACEEKVSAKDEKELLHLSIEQEIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLS 1334
Cdd:pfam05483  535 QIENLEEKEMNLRDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELH 614

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*....
gi 1270530344 1335 QLTYSSGSPTKRQSQLVDTLQQRVRDLQQQLADADRQHQEVIAIYRTHL 1383
Cdd:pfam05483  615 QENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEI 663
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 449-1336 3.80e-06

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 51.59  E-value: 3.80e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  449 KELETLRTYYDSAKQDRLKFQNELAHKVAEckalaLECERvkedsdEQIKQLEDALKDVQKRMYESEgkvkQMQTHFLAL 528
Cdd:TIGR00606  203 QEHQMELKYLKQYKEKACEIRDQITSKEAQ-----LESSR------EIVKSYENELDPLKNRLKEIE----HNLSKIMKL 267

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  529 KEHLTNEAATGSHRiiEELREQLKDLKGK-YEGASAEVGKLRsqikqsemlvgEFKRDEGRLVEEnkrlqkECGTCEVEL 607
Cdd:TIGR00606  268 DNEIKALKSRKKQM--EKDNSELELKMEKvFQGTDEQLNDLY-----------HNHQRTVREKER------ELVDCQREL 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  608 ERRGRRVVELEGQLKELgaklalsvpteKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHirpE 687
Cdd:TIGR00606  329 EKLNKERRLLNQEKTEL-----------LVEQGRLQLQADRHQEHIRARDSLIQSLATRLELDGFERGPFSERQIK---N 394

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  688 EHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQqvhslTVEMKTRYVPLRVSE-EMKKSHDVNVEDL 766
Cdd:TIGR00606  395 FHTLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGR-----TIELKKEILEKKQEElKFVIKELQQLEGS 469

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  767 NKKLSEATQRYTekKQEAERLLAENDKLT-------KNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGEG 839
Cdd:TIGR00606  470 SDRILELDQELR--KAERELSKAEKNSLTetlkkevKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDK 547

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  840 QEKIRALMSENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQ 919
Cdd:TIGR00606  548 DEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDK 627

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  920 MkADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLhaeikaqkkeLDTIQECIKLkyaplarleeCERK 999
Cdd:TIGR00606  628 L-FDVCGSQDEESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQL----------TDENQSCCPV----------CQRV 686

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1000 FKaTEKGLKEQLSEQTHKCR-------QRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSK 1072
Cdd:TIGR00606  687 FQ-TEAELQEFISDLQSKLRlapdklkSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKN 765

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1073 QLKDLSQKYSDVKSErEKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNG--TIEQLKEELRSKQRCLEREQQT 1150
Cdd:TIGR00606  766 DIEEQETLLGTIMPE-EESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGSDLdrTVQQVNQEKQEKQHELDTVVSK 844

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1151 VSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTK-------QALKNLETR 1223
Cdd:TIGR00606  845 IELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKeqdspleTFLEKDQQE 924

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1224 EVVDMSKYKATK-------NDLETQISNLNDKLASLNRKYDQACEEKVSAKdEKELLHLSIE-QEIRDQKERCDKSLTTI 1295
Cdd:TIGR00606  925 KEELISSKETSNkkaqdkvNDIKEKVKNIHGYMKDIENKIQDGKDDYLKQK-ETELNTVNAQlEECEKHQEKINEDMRLM 1003

                          890       900       910       920
                   ....*....|....*....|....*....|....*....|....
gi 1270530344 1296 MEL--QQRIQESAKQIEAKDNKITELLNDVER-LKQALNGLSQL 1336
Cdd:TIGR00606 1004 RQDidTQKIQERWLQDNLTLRKRENELKEVEEeLKQHLKEMGQM 1047
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 152-254 4.01e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 51.03  E-value: 4.01e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  152 IQLLCDHGASVNAKDID-GRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTL 230
Cdd:PHA02878   150 TKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA 229

                           90       100
                   ....*....|....*....|....*...
gi 1270530344  231 LDALG----HDSSYYARigdNLDILNLL 254
Cdd:PHA02878   230 RDKCGntplHISVGYCK---DYDILKLL 254
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
471-957 4.20e-06

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 51.58  E-value: 4.20e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  471 ELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRmyesegkvkqmqthflalKEHLTNEAATGSHRiIEELREQ 550
Cdd:PRK02224   255 TLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEE------------------RDDLLAEAGLDDAD-AEAVEAR 315

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  551 LKDLKGKYEGASAEVGKLRSQI----KQSEMLVGEFKRDEGR---LVEENKRLQKECGTCEVELERRGRRVVELEGQLKE 623
Cdd:PRK02224   316 REELEDRDEELRDRLEECRVAAqahnEEAESLREDADDLEERaeeLREEAAELESELEEAREAVEDRREEIEELEEEIEE 395

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  624 LGAKLA-LSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVR----AQHIRPEEHEQLRSRLEQ 698
Cdd:PRK02224   396 LRERFGdAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEAGKcpecGQPVEGSPHVETIEEDRE 475

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  699 KSGELGKKVSELTLKNQTLQKDVEKLHADNKL------LNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSE 772
Cdd:PRK02224   476 RVEELEAELEDLEEEVEEVEERLERAEDLVEAedrierLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEE 555

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  773 ATQRYTEKKQEAERLLAE----NDKLTKNVSRLEAVfvapekheKELMGLKSNIAELKKQLSELNKK---CGEGQEKIRA 845
Cdd:PRK02224   556 KREAAAEAEEEAEEAREEvaelNSKLAELKERIESL--------ERIRTLLAAIADAEDEIERLREKreaLAELNDERRE 627

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  846 LMSENSSLKKTLSSQYVPAKTHE--EVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEvlrrNLENVQNQMKAd 923
Cdd:PRK02224   628 RLAEKRERKRELEAEFDEARIEEarEDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENELE----ELEELRERREA- 702

                          490       500       510
                   ....*....|....*....|....*....|....
gi 1270530344  924 yvsLEEHSRRMSTVSQSLKEAQEANAAILADHRQ 957
Cdd:PRK02224   703 ---LENRVEALEALYDEAEELESMYGDLRAELRQ 733
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 492-934 4.55e-06

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 51.33  E-value: 4.55e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  492 DSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHltNEAATGSHRIIEELREQLKDLKGKYEGASAEVGKLRSq 571
Cdd:pfam01576  107 DLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQ--NSKLSKERKLLEERISEFTSNLAEEEEKAKSLSKLKN- 183

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  572 ikQSEMLVGEFkrdEGRLVEENK---RLQKECGTCEVELERRGRRVVELEGQLKELGAKLAlsvpteKFESMKSSLSNDI 648
Cdd:pfam01576  184 --KHEAMISDL---EERLKKEEKgrqELEKAKRKLEGESTDLQEQIAELQAQIAELRAQLA------KKEEELQAALARL 252

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  649 NEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPEEH-------------------------EQLRSRLEQKSGEL 703
Cdd:pfam01576  253 EEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQrrdlgeelealkteledtldttaaqQELRSKREQEVTEL 332

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  704 GKKVSELTLKNQTLQKDVEKLHAD----------------------NKLLNQQVHSLTVEMKTRYVPLRVSEEMKKSHDV 761
Cdd:pfam01576  333 KKALEEETRSHEAQLQEMRQKHTQaleelteqleqakrnkanlekaKQALESENAELQAELRTLQQAKQDSEHKRKKLEG 412

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  762 NVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVapeKHEKELMGLKSNIAELKKQLSELNKKCGEGQE 841
Cdd:pfam01576  413 QLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNI---KLSKDVSSLESQLQDTQELLQEETRQKLNLST 489

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  842 KIRALMSENSSLKKTLSSQyvpakthEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMK 921
Cdd:pfam01576  490 RLRQLEDERNSLQEQLEEE-------EEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLE 562

                          490
                   ....*....|....*.
gi 1270530344  922 ---ADYVSLEEHSRRM 934
Cdd:pfam01576  563 ekaAAYDKLEKTKNRL 578
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 425-921 5.29e-06

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 51.17  E-value: 5.29e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  425 RSMLRPLELSLPSQTSYSE-NEILKKELETLRTYYDSAKQDRLKFQNELAHKVAECKALALECERVKEDSDEQIKQLEDA 503
Cdd:TIGR04523  193 KNKLLKLELLLSNLKKKIQkNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEK 272

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  504 LKDVQKrmyeSEGKVKQMQTHFLALKEHLTNEAATGSHRIIEELREQLKDLKGKYEgasaevgKLRSQIKQSEMLVGEFK 583
Cdd:TIGR04523  273 QKELEQ----NNKKIKELEKQLNQLKSEISDLNNQKEQDWNKELKSELKNQEKKLE-------EIQNQISQNNKIISQLN 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  584 RDEGRLVEENKRLQKECGTCEVELERRGRRVVELEGQLKELGAKLalsvptEKFESMKSSLSNDINEKVKRLAEVGRDYE 663
Cdd:TIGR04523  342 EQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEI------KNLESQINDLESKIQNQEKLNQQKDEQIK 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  664 SAQGEIRQLKRDLESVRAQHIrpeEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMK 743
Cdd:TIGR04523  416 KLQQEKELLEKEIERLKETII---KNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELK 492

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  744 TRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQRY----TEKKQEAERLLAENDKLTKNVSRLEAvfvapEKHEKELMGLK 819
Cdd:TIGR04523  493 SKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIekleSEKKEKESKISDLEDELNKDDFELKK-----ENLEKEIDEKN 567

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  820 SNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLssqyvpaktheevkASLNSTVEKTNRALLEAKKRFDDTSQEV 899
Cdd:TIGR04523  568 KEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEI--------------EEKEKKISSLEKELEKAKKENEKLSSII 633

                          490       500
                   ....*....|....*....|..
gi 1270530344  900 SKLRDENEVLRRNLENVQNQMK 921
Cdd:TIGR04523  634 KNIKSKKNKLKQEVKQIKETIK 655
PRK01156 PRK01156
chromosome segregation protein; Provisional
 300-896 6.18e-06

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 51.06  E-value: 6.18e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  300 SFQDLEIENEDLREKLRKIQQEQRILLDKVNGLQLQLNEEVMVADD---LESEREKLKSLLAAKEKQHEEslrtIEALKN 376
Cdd:PRK01156   205 QIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSSLEDMknrYESEIKTAESDLSMELEKNNY----YKELEE 280

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  377 RFKYFESDhpgPGSYPSNRKEDMLHKQGQMYTTEPQCASPGIPPHMHSRSMLRPLELslpsQTSYSENEILKKELETLRT 456
Cdd:PRK01156   281 RHMKIIND---PVYKNRNYINDYFKYKNDIENKKQILSNIDAEINKYHAIIKKLSVL----QKDYNDYIKKKSRYDDLNN 353

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  457 YYDSAKQDRLKFQNELAHKVAECKALALECERVKEDSDEQIKQLEDA----------LKDVQKRMYESEGKVKQMQTHFL 526
Cdd:PRK01156   354 QILELEGYEMDYNSYLKSIESLKKKIEEYSKNIERMSAFISEILKIQeidpdaikkeLNEINVKLQDISSKVSSLNQRIR 433

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  527 ALKEHLtneaatgshriiEELREQLKDLKGKyegASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVE 606
Cdd:PRK01156   434 ALRENL------------DELSRNMEMLNGQ---SVCPVCGTTLGEEKSNHIINHYNEKKSRLEEKIREIEIEVKDIDEK 498

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  607 LERRGRRVVELEGQLKElgaklALSVPTEKFESMKSSLSnDINEKVKRLAEVGRDYESAQGEIRQLK-RDLESVRAQH-- 683
Cdd:PRK01156   499 IVDLKKRKEYLESEEIN-----KSINEYNKIESARADLE-DIKIKINELKDKHDKYEEIKNRYKSLKlEDLDSKRTSWln 572

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  684 ----IRPEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKKSh 759
Cdd:PRK01156   573 alavISLIDIETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYIDKSIREIENEANNLNNKYNEIQENKILIEKLRGK- 651

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  760 dvnVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCgEG 839
Cdd:PRK01156   652 ---IDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIEILRTRINELSDRINDINETL-ES 727

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1270530344  840 QEKIRALMSENSSLKKTLSSQYVPAKTHEEVKASLNStveKTNRALLEAKKRFDDTS 896
Cdd:PRK01156   728 MKKIKKAIGDLKRLREAFDKSGVPAMIRKSASQAMTS---LTRKYLFEFNLDFDDID 781
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 840-1366 7.98e-06

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 50.74  E-value: 7.98e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  840 QEKIRALMSENSSLKKTLSSQYVPAKTHE----EVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLEN 915
Cdd:TIGR00618  151 QGEFAQFLKAKSKEKKELLMNLFPLDQYTqlalMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKH 230

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  916 VQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAiladhRQGQEEIVSLHAEIKAQKKELDtiQECIKLKYAP-LARLE 994
Cdd:TIGR00618  231 LREALQQTQQSHAYLTQKREAQEEQLKKQQLLKQL-----RARIEELRAQEAVLEETQERIN--RARKAAPLAAhIKAVT 303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  995 ECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADE----- 1069
Cdd:TIGR00618  304 QIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTqhiht 383

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1070 LSKQLKDLSQKYSDVKSEREKLVEEKAKQASEiLAAQNLLQKQPVPLEQVEALkkslngtieqlkeelrskqrclerEQQ 1149
Cdd:TIGR00618  384 LQQQKTTLTQKLQSLCKELDILQREQATIDTR-TSAFRDLQGQLAHAKKQQEL------------------------QQR 438

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1150 TVSQLQQLLENQknssvtlAEHLKLKEALEKEvgiMKASLREKEEESQKK---TKEVSKLQTEVQTTKQALKNLETREVV 1226
Cdd:TIGR00618  439 YAELCAAAITCT-------AQCEKLEKIHLQE---SAQSLKEREQQLQTKeqiHLQETRKKAVVLARLLELQEEPCPLCG 508

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1227 DMSKYKATKNDLETQISNLNDKLASLNR-KYDQACEEKVSAKDEKELLHLsieQEIRDQKERCDKSLTTIMELQQRIQES 1305
Cdd:TIGR00618  509 SCIHPNPARQDIDNPGPLTRRMQRGEQTyAQLETSEEDVYHQLTSERKQR---ASLKEQMQEIQQSFSILTQCDNRSKED 585

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1270530344 1306 AKQIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDLQQQLA 1366
Cdd:TIGR00618  586 IPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLT 646
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
487-698 1.26e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 49.63  E-value: 1.26e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  487 ERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQthflalKEHL---TNEAATGSHRIIEELREQLKDLKGKYEGASA 563
Cdd:COG3206    167 ELRREEARKALEFLEEQLPELRKELEEAEAALEEFR------QKNGlvdLSEEAKLLLQQLSELESQLAEARAELAEAEA 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  564 EVGKLRSQIKQSEMLVGEFKRDEG--RLVEENKRLQKEcgtcEVELERRGR----RVVELEGQLKELGAKLA-------- 629
Cdd:COG3206    241 RLAALRAQLGSGPDALPELLQSPViqQLRAQLAELEAE----LAELSARYTpnhpDVIALRAQIAALRAQLQqeaqrila 316

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  630 -LSVPTEKFESMKSSLSNDINEKVKRLAEVGRdyesAQGEIRQLKRDLESVRAQhirpeeHEQLRSRLEQ 698
Cdd:COG3206    317 sLEAELEALQAREASLQAQLAQLEARLAELPE----LEAELRRLEREVEVAREL------YESLLQRLEE 376
PRK12704 PRK12704
phosphodiesterase; Provisional
 1075-1231 1.91e-05

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 49.01  E-value: 1.91e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1075 KDLSQKYSDVKSEREKLVEEKAKQASE-----ILAAQNLLQKQpvpLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQ 1149
Cdd:PRK12704    27 KIAEAKIKEAEEEAKRILEEAKKEAEAikkeaLLEAKEEIHKL---RNEFEKELRERRNELQKLEKRLLQKEENLDRKLE 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1150 TVSQLQQLLENQKNSSvtlaehlklkEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEvQTTKQALKNLETREVVDMS 1229
Cdd:PRK12704   104 LLEKREEELEKKEKEL----------EQKQQELEKKEEELEELIEEQLQELERISGLTAE-EAKEILLEKVEEEARHEAA 172


                   ..
gi 1270530344 1230 KY 1231
Cdd:PRK12704   173 VL 174
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1145-1391 1.93e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.61  E-value: 1.93e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1145 EREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEvgimkasLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETRE 1224
Cdd:COG4942     20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQ-------LAALERRIAALARRIRALEQELAALEAELAELEKEI 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1225 vvdmskyKATKNDLETQISNLNDKLASLNRKYDQACEE-KVSAKDEKELLHLS--IEQEIRDQKERCDKSLTTIMELQQR 1301
Cdd:COG4942     93 -------AELRAELEAQKEELAELLRALYRLGRQPPLAlLLSPEDFLDAVRRLqyLKYLAPARREQAEELRADLAELAAL 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1302 IQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDLQQQLADADRQHQEVIAIYRT 1381
Cdd:COG4942    166 RAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPA 245

                          250
                   ....*....|
gi 1270530344 1382 HLLSAAQGHM 1391
Cdd:COG4942    246 AGFAALKGKL 255
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1066-1293 2.22e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.61  E-value: 2.22e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1066 KADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEilaaqnllqkqpvpLEQVEALKKSLNGTIEQLKEELRSKQRCLE 1145
Cdd:COG4942     21 AAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQ--------------LAALERRIAALARRIRALEQELAALEAELA 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1146 REQQTVSQLQQLLENQKN-------SSVTLAEHLKLKEALE----KEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTK 1214
Cdd:COG4942     87 ELEKEIAELRAELEAQKEelaellrALYRLGRQPPLALLLSpedfLDAVRRLQYLKYLAPARREQAEELRADLAELAALR 166

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1270530344 1215 QALKNLETREVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERCDKSLT 1293
Cdd:COG4942    167 AELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPA 245
Ank_2 pfam12796
Ankyrin repeats (3 copies);
40-100 2.49e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 44.34  E-value: 2.49e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1270530344   40 LMKAAERGDVEKVSSILAKKGVhpgKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRD 100
Cdd:pfam12796   34 LHLAAKNGHLEIVKLLLEHADV---NLKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
 975-1365 2.58e-05

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 48.14  E-value: 2.58e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  975 ELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVK-------KGKQENERLRADLAALQKELQ 1047
Cdd:pfam19220   21 DLRSLKADFSQLIEPIEAILRELPQAKSRLLELEALLAQERAAYGKLRRELAgltrrlsAAEGELEELVARLAKLEAALR 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1048 DRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLN 1127
Cdd:pfam19220  101 EAEAAKEELRIELRDKTAQAEALERQLAAETEQNRALEEENKALREEAQAAEKALQRAEGELATARERLALLEQENRRLQ 180

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1128 GTIEQLKEELRSKQRCL-EREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMK---ASLREKEEESQKKTKEV 1203
Cdd:pfam19220  181 ALSEEQAAELAELTRRLaELETQLDATRARLRALEGQLAAEQAERERAEAQLEEAVEAHRaerASLRMKLEALTARAAAT 260

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1204 SKLQTEVQTtkqalknletrevvdmskykatkndletqisNLNDKLASLnRKYDQACEEKVSAKDEKELLHLSIEQEIRD 1283
Cdd:pfam19220  261 EQLLAEARN-------------------------------QLRDRDEAI-RAAERRLKEASIERDTLERRLAGLEADLER 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1284 QKERCDKSLTTIMELQQRIQESAKQIEAKDNKitellndverLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDLQQ 1363
Cdd:pfam19220  309 RTQQFQEMQRARAELEERAEMLTKALAAKDAA----------LERAEERIASLSDRIAELTKRFEVERAALEQANRRLKE 378


                   ..
gi 1270530344 1364 QL 1365
Cdd:pfam19220  379 EL 380
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 536-745 2.88e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.22  E-value: 2.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  536 AATGSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERRGRRVV 615
Cdd:COG4942     14 AAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIA 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  616 ELEGQLKELGAKLALSVPTEKFESMKSSL-----SNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPE--- 687
Cdd:COG4942     94 ELRAELEAQKEELAELLRALYRLGRQPPLalllsPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEaer 173

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1270530344  688 --------EHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTR 745
Cdd:COG4942    174 aeleallaELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAA 239
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 107-235 3.00e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 48.47  E-value: 3.00e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  107 LHLAAKYGHALCLQKLLQYNcpteHVDLQ-----GRTALHDAAMADCPSSIQLLCDhgasvNAKDI----------DGRT 171
Cdd:cd22192     21 LLLAAKENDVQAIKKLLKCP----SCDLFqrgalGETALHVAALYDNLEAAVVLME-----AAPELvnepmtsdlyQGET 91

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1270530344  172 PLVLATQMCRPTICQLLIDRGADVNSRD------KQNRTALMLGCEY--------GCRDAVEVLVKNGADLTLLDALG 235
Cdd:cd22192     92 ALHIAVVNQNLNLVRELIARGADVVSPRatgtffRPGPKNLIYYGEHplsfaacvGNEEIVRLLIEHGADIRAQDSLG 169
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
883-1381 3.01e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 48.76  E-value: 3.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  883 RALLEAKKRFDDTSQEVSKLRDENEVLRRnLENVQNQMKADYVSLEEHSRRMSTV-----SQSLKEAQEANAAILADHRQ 957
Cdd:COG4913    228 DALVEHFDDLERAHEALEDAREQIELLEP-IRELAERYAAARERLAELEYLRAALrlwfaQRRLELLEAELEELRAELAR 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  958 GQEEIVSLHAEIKAQKKELDTIQEciKLKYAPLARLEECERKFKAtekgLKEQLSEQTHKCRQRDEEVKKGKQENERLRA 1037
Cdd:COG4913    307 LEAELERLEARLDALREELDELEA--QIRGNGGDRLEQLEREIER----LERELEERERRRARLEALLAALGLPLPASAE 380

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1038 DLAALQKELQDRnalaeeareaeralsgkADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEIlaaQNLLQKQ---PV 1114
Cdd:COG4913    381 EFAALRAEAAAL-----------------LEALEEELEALEEALAEAEAALRDLRRELRELEAEI---ASLERRKsniPA 440

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1115 PLEQV-EALKKSLNGTIEQLK---E--ELRSKQ-----------------------------RCLEREQQT-------VS 1152
Cdd:COG4913    441 RLLALrDALAEALGLDEAELPfvgEliEVRPEEerwrgaiervlggfaltllvppehyaaalRWVNRLHLRgrlvyerVR 520

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1153 QLQQLLENQKNSSVTLAEHLKLKE-----ALEKEVG--------------------IMKASLREKEEESQKKTKEVSKLQ 1207
Cdd:COG4913    521 TGLPDPERPRLDPDSLAGKLDFKPhpfraWLEAELGrrfdyvcvdspeelrrhpraITRAGQVKGNGTRHEKDDRRRIRS 600

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1208 TEV--QTTKQALKNLETRevvdMSKYKATKNDLETQISNLNDKLASLNRKYDQAceEKVSAKDEKELLHLSIEQEIR--- 1282
Cdd:COG4913    601 RYVlgFDNRAKLAALEAE----LAELEEELAEAEERLEALEAELDALQERREAL--QRLAEYSWDEIDVASAEREIAele 674

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1283 DQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLtyssgspTKRQSQLVDTLQQRVRDLQ 1362
Cdd:COG4913    675 AELERLDASSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEE-------LDELQDRLEAAEDLARLEL 747

                          570
                   ....*....|....*....
gi 1270530344 1363 QQLADADRQHQEVIAIYRT 1381
Cdd:COG4913    748 RALLEERFAAALGDAVERE 766
46 PHA02562
endonuclease subunit; Provisional
 720-984 3.54e-05

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 48.09  E-value: 3.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  720 DVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQR----YTEKKQEAERLLAENDKLT 795
Cdd:PHA02562   161 DISVLSEMDKLNKDKIRELNQQIQTLDMKIDHIQQQIKTYNKNIEEQRKKNGENIARkqnkYDELVEEAKTIKAEIEELT 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  796 knvSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKcgegqekirALMSENSSLKKTLSSQYvpaKTHEEVKASLN 875
Cdd:PHA02562   241 ---DELLNLVMDIEDPSAALNKLNTAAAKIKSKIEQFQKV---------IKMYEKGGVCPTCTQQI---SEGPDRITKIK 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  876 STVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLrRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADH 955
Cdd:PHA02562   306 DKLKELQHSLEKLDTAIDELEEIMDEFNEQSKKL-LELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFVDNAEELAKL 384

                          250       260
                   ....*....|....*....|....*....
gi 1270530344  956 RQGQEEIVSLHAEIKAQKKELDTIQECIK 984
Cdd:PHA02562   385 QDELDKIVKTKSELVKEKYHRGIVTDLLK 413
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1066-1271 3.70e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 47.90  E-value: 3.70e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1066 KADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQpvpLEQVEALKKSLNGTIEQLKEELRSKQRcle 1145
Cdd:COG3883     24 ELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKL---QAEIAEAEAEIEERREELGERARALYR--- 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1146 rEQQTVSQLQQLLENQKNSSVtlaehlklkealekevgIMKASLREKEEESQKKT-KEVSKLQTEVQTTKQALKNLETRE 1224
Cdd:COG3883     98 -SGGSVSYLDVLLGSESFSDF-----------------LDRLSALSKIADADADLlEELKADKAELEAKKAELEAKLAEL 159

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 1270530344 1225 VVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKE 1271
Cdd:COG3883    160 EALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELA 206
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 498-1380 5.20e-05

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 47.86  E-value: 5.20e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  498 KQLEDALKDVQKRMYESEGKVKQMQThfLALKEHLTNEAATGSHRIIEELREQLKDLKGKYEGASAEvgkLRSQIKQSEM 577
Cdd:pfam01576  155 KLLEERISEFTSNLAEEEEKAKSLSK--LKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTD---LQEQIAELQA 229

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  578 LVGEFKrdeGRLVEENKRLQKECGTCEVELERRG---RRVVELEGQLKELGAKLALS-VPTEKFESMKSSLSNDInEKVK 653
Cdd:pfam01576  230 QIAELR---AQLAKKEEELQAALARLEEETAQKNnalKKIRELEAQISELQEDLESErAARNKAEKQRRDLGEEL-EALK 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  654 RLAEVGRDYESAQGEIR--------QLKRDLESVRAQHirPEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLH 725
Cdd:pfam01576  306 TELEDTLDTTAAQQELRskreqevtELKKALEEETRSH--EAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALE 383

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  726 ADNKllnqqvhSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVF 805
Cdd:pfam01576  384 SENA-------ELQAELRTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKN 456

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  806 VapeKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSSQyvpakthEEVKASLNSTVEKTNRAL 885
Cdd:pfam01576  457 I---KLSKDVSSLESQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEE-------EEAKRNVERQLSTLQAQL 526

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  886 LEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMK---ADYVSLEEHSRRMSTVSQSLKEAQEANAAILA--------- 953
Cdd:pfam01576  527 SDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEekaAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSnlekkqkkf 606

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  954 DHRQGQEEIVSLH-------AEIKAQKKELDTIQECIKLKYAPLARlEECERKFKATEKGLKEQLSEQ--THKCRQRDEE 1024
Cdd:pfam01576  607 DQMLAEEKAISARyaeerdrAEAEAREKETRALSLARALEEALEAK-EELERTNKQLRAEMEDLVSSKddVGKNVHELER 685

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1025 VKKG-KQENERLRADLAALQKELQD---------------RNALAEEAREAERALSGKADELSKQLKDLsqkysdvkser 1088
Cdd:pfam01576  686 SKRAlEQQVEEMKTQLEELEDELQAtedaklrlevnmqalKAQFERDLQARDEQGEEKRRQLVKQVREL----------- 754

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1089 EKLVEEKAKQASEILAAQNLLQKQPVPLE-QVEALKKSLNGTIEQLKE---ELRSKQRCLEREQQTVSQ-LQQLLENQKN 1163
Cdd:pfam01576  755 EAELEDERKQRAQAVAAKKKLELDLKELEaQIDAANKGREEAVKQLKKlqaQMKDLQRELEEARASRDEiLAQSKESEKK 834

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1164 SSVTLAEHLKLKEALekevgimKASLREKEEESQkktkEVSKLQTEVQ---TTKQALKNLETREVVDMSKYKATKNDLET 1240
Cdd:pfam01576  835 LKNLEAELLQLQEDL-------AASERARRQAQQ----ERDELADEIAsgaSGKSALQDEKRRLEARIAQLEEELEEEQS 903

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1241 QISNLNDKLASLNRKYDQ-----ACEEKVSAKDEKELLHLsiEQEIRDQKERCD--------KSLTTIMELQQRIQESAK 1307
Cdd:pfam01576  904 NTELLNDRLRKSTLQVEQlttelAAERSTSQKSESARQQL--ERQNKELKAKLQemegtvksKFKSSIAALEAKIAQLEE 981

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1270530344 1308 QIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDLQQQLADADRQHQEVIAIYR 1380
Cdd:pfam01576  982 QLEQESRERQAANKLVRRTEKKLKEVLLQVEDERRHADQYKDQAEKGNSRMKQLKRQLEEAEEEASRANAARR 1054
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 787-1049 5.30e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.07  E-value: 5.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  787 LLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRAlmsensslkktlssqyvpakt 866
Cdd:COG4942     15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRA--------------------- 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  867 heevkasLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDEnevLRRNLENVQNQMKADYVSL---EEHSRRMSTVSQSLKE 943
Cdd:COG4942     74 -------LEQELAALEAELAELEKEIAELRAELEAQKEE---LAELLRALYRLGRQPPLALllsPEDFLDAVRRLQYLKY 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  944 AQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIqeciklkyapLARLEECERKFKATEKGLKEQLSEQTHKCRQRDE 1023
Cdd:COG4942    144 LAPARREQAEELRADLAELAALRAELEAERAELEAL----------LAELEEERAALEALKAERQKLLARLEKELAELAA 213

                          250       260
                   ....*....|....*....|....*.
gi 1270530344 1024 EVKKGKQENERLRADLAALQKELQDR 1049
Cdd:COG4942    214 ELAELQQEAEELEALIARLEAEAAAA 239
COG5022 COG5022
Myosin heavy chain [General function prediction only];
960-1331 5.35e-05

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 48.15  E-value: 5.35e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  960 EEIVSLHAEIKAQKKELDTIQECIKLKYAPLarLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGkqenerlradl 1039
Cdd:COG5022    817 ACIIKLQKTIKREKKLRETEEVEFSLKAEVL--IQKFGRSLKAKKRFSLLKKETIYLQSAQRVELAERQ----------- 883

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1040 aalQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEqv 1119
Cdd:COG5022    884 ---LQELKIDVKSISSLKLVNLELESEIIELKKSLSSDLIENLEFKTELIARLKKLLNNIDLEEGPSIEYVKLPELNK-- 958

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1120 ealkksLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVgimkASLREKEEESQKK 1199
Cdd:COG5022    959 ------LHEVESKLKETSEEYEDLLKKSTILVREGNKANSELKNFKKELAELSKQYGALQEST----KQLKELPVEVAEL 1028

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1200 TKEVSKLQTEvQTTKQALKNLETREVVDMSKYKAT-KNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIE 1278
Cdd:COG5022   1029 QSASKIISSE-STELSILKPLQKLKGLLLLENNQLqARYKALKLRRENSLLDDKQLYQLESTENLLKTINVKDLEVTNRN 1107

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1270530344 1279 QEIRDQKERCDKSLTTIMELQQRIQESAKQ----IEAKDNKITELLNDVERLKQALN 1331
Cdd:COG5022   1108 LVKPANVLQFIVAQMIKLNLLQEISKFLSQlvntLEPVFQKLSVLQLELDGLFWEAN 1164
Ank_4 pfam13637
Ankyrin repeats (many copies);
103-155 7.20e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.88  E-value: 7.20e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1270530344  103 GRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLL 155
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
Ank_5 pfam13857
Ankyrin repeats (many copies);
55-110 8.53e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.56  E-value: 8.53e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1270530344   55 ILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLA 110
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
AAA_13 pfam13166
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
 641-1048 9.58e-05

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. This family includes the PrrC protein that is thought to be the active component of the anticodon nuclease.


Pssm-ID: 463796 [Multi-domain]  Cd Length: 712  Bit Score: 46.98  E-value: 9.58e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  641 KSSLSNDI-----NEKVKRLAEVGRDYESAQGE-IRQLKRDL--ESVRAQ-HIRP-----EEHEQLRSRLEQKSGELGKK 706
Cdd:pfam13166   29 KTTLSRLLrslelGEPHPKFANGKFEWTNGQPLdIRVFNRDFveENLSEQgEIKPiftlgEESIEIQEKIAKLKKEIKDH 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  707 VSELTLKNQTLQ---KDVEKLHAD-NKLLNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVnvEDLNKKLSEATQRYTEKKQ 782
Cdd:pfam13166  109 EEKLDAAEANLQkldKEKEKLEADfLDECWKKIKRKKNSALSEALNGFKYEANFKSRLL--REIEKDNFNAGVLLSDEDR 186

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  783 EA------ERLLAENDKLTKNVSRLEAVFVAPEKHEKeLMGLKSNIAELKKQLSeLNKKCGEGQEKIRALMSE------- 849
Cdd:pfam13166  187 KAalatvfSDNKPEIAPLTFNVIDFDALEKAEILIQK-VIGKSSAIEELIKNPD-LADWVEQGLELHKAHLDTcpfcgqp 264

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  850 -NSSLKKTLSSQYvpAKTHEEVKASLNSTVEKTNRALLEAKKRFD---DTSQEVSKLRDENEVLRRNLENVQNQMKADYV 925
Cdd:pfam13166  265 lPAERKAALEAHF--DDEFTEFQNRLQKLIEKVESAISSLLAQLPavsDLASLLSAFELDVEDIESEAEVLNSQLDGLRR 342

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  926 SLEEHSRRMSTVSQ---------SLKEAQEANAAILADHrqgqEEIVSLHAEIKAQKK---ELDTIQECiklkYAPLARL 993
Cdd:pfam13166  343 ALEAKRKDPFKSIEldsvdakieSINDLVASINELIAKH----NEITDNFEEEKNKAKkklRLHLVEEF----KSEIDEY 414

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1270530344  994 EECERKFKATEKGLKEQLSEQTHKCRQRDEEVKkgkqenerlradlaALQKELQD 1048
Cdd:pfam13166  415 KDKYAGLEKAINSLEKEIKNLEAEIKKLREEIK--------------ELEAQLRD 455
Ank_5 pfam13857
Ankyrin repeats (many copies);
188-235 9.59e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.56  E-value: 9.59e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1270530344  188 LIDRG-ADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALG 235
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEG 49
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1100-1252 1.24e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 45.30  E-value: 1.24e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1100 SEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSsvtLAEHLKLKE--A 1177
Cdd:COG1579     17 SELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQ---LGNVRNNKEyeA 93

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1270530344 1178 LEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVDMSKYKATKNDLETQISNLNDKLASL 1252
Cdd:COG1579     94 LQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREEL 168
Ank_4 pfam13637
Ankyrin repeats (many copies);
36-86 1.41e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.72  E-value: 1.41e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1270530344   36 YDDRLMKAAERGDVEKVSSILaKKGVHPGKLDVEGRSAFHVVASKGNLECL 86
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLL-EKGADINAVDGNGETALHFAASNGNVEVL 50
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 305-1221 1.51e-04

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 46.58  E-value: 1.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  305 EIENEDLREKLRKIQQEQRILLdkvnglqlQLNEEVMVADDLESEREKLKSLLAAKEKQ----HEESLRTIEALKNRfky 380
Cdd:TIGR00606  244 ENELDPLKNRLKEIEHNLSKIM--------KLDNEIKALKSRKKQMEKDNSELELKMEKvfqgTDEQLNDLYHNHQR--- 312

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  381 fESDHPGPGSYPSNRKEDMLHKQGQMYTTE----------PQCASPGIPPHMHSRSMLRpLELSLPSQTSYSENE-ILKK 449
Cdd:TIGR00606  313 -TVREKERELVDCQRELEKLNKERRLLNQEktellveqgrLQLQADRHQEHIRARDSLI-QSLATRLELDGFERGpFSER 390

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  450 ELETLRTYYDSAKQDRLKFQNELAHKVAECKALAlecervkedsDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALK 529
Cdd:TIGR00606  391 QIKNFHTLVIERQEDEAKTAAQLCADLQSKERLK----------QEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVI 460

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  530 EHLTNeAATGSHRIIE---ELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLvgEFKRDEGRLVEENKRLQKEcGTCEVE 606
Cdd:TIGR00606  461 KELQQ-LEGSSDRILEldqELRKAERELSKAEKNSLTETLKKEVKSLQNEKA--DLDRKLRKLDQEMEQLNHH-TTTRTQ 536

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  607 LERRGRRVVELEGQLK--------ELGAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLES 678
Cdd:TIGR00606  537 MEMLTKDKMDKDEQIRkiksrhsdELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELES 616

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  679 VRAQHIRPEEHEQLRSRLEQKSGELGKKVSELtlknQTLQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKKS 758
Cdd:TIGR00606  617 KEEQLSSYEDKLFDVCGSQDEESDLERLKEEI----EKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAE 692

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  759 HDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFvapEKHEKELMGLKSNIAELKKQLSELNKKCGE 838
Cdd:TIGR00606  693 LQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSII---DLKEKEIPELRNKLQKVNRDIQRLKNDIEE 769

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  839 GQEKIRALMSENSSLKKTLSSQYVPAKTHEEVK------ASLNSTVEKTN--RALLEAKKRFDDTSQEVSKLRDENEVLR 910
Cdd:TIGR00606  770 QETLLGTIMPEEESAKVCLTDVTIMERFQMELKdverkiAQQAAKLQGSDldRTVQQVNQEKQEKQHELDTVVSKIELNR 849

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  911 RNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQeanaailadhrQGQEEIVSLHAEIKAQKKEldtiqecIKLKYAPL 990
Cdd:TIGR00606  850 KLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQ-----------QFEEQLVELSTEVQSLIRE-------IKDAKEQD 911

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  991 ARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRnalaeEAREAERALSGKADEL 1070
Cdd:TIGR00606  912 SPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGKDD-----YLKQKETELNTVNAQL 986

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1071 SKQLKDLSQKYSDVKSEREKLveEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKeelrskqrcLEREQQT 1150
Cdd:TIGR00606  987 EECEKHQEKINEDMRLMRQDI--DTQKIQERWLQDNLTLRKRENELKEVEEELKQHLKEMGQMQ---------VLQMKQE 1055

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1270530344 1151 VSQLQQLLENQKNSSVTLAEHLKlkeALEKEVGIMKASLREKeeESQKKTKEVSKLQTEVQTTKQALKNLE 1221
Cdd:TIGR00606 1056 HQKLEENIDLIKRNHVLALGRQK---GYEKEIKHFKKELREP--QFRDAEEKYREMMIVMRTTELVNKDLD 1121
CagA_N pfam18971
CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial ...
 767-1202 1.62e-04

CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial virulence determinant and critical for gastric carcinogenesis. X-ray crystallographic analysis of the N-terminal CagA fragment (residues 1-876) revealed that the region has a structure comprised of three discrete domains. Domain I constitutes a mobile CagA N terminus, while Domain II tethers CagA to the plasma membrane by interacting with membrane phosphatidylserine. Domain III interacts intramolecularly with the intrinsically disordered C-terminal region, and this interaction potentiates the pathogenic scaffold/hub function of CagA.


Pssm-ID: 408741 [Multi-domain]  Cd Length: 876  Bit Score: 46.30  E-value: 1.62e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  767 NKKLSEATQRYTEKKQ-EAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKira 845
Cdd:pfam18971  412 NTKLDNLSEKEKEKFQnEIEDFQKDSKAYLDALGNDRIAFVSKKDTKHSALITEFNNGDLSYTLKDYGKKADKALDR--- 488

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  846 lmSENSSLKKTLSSQ---YVPAKTHEEVKASLNST--VEKTNR-ALLEAKkrFDDTSqeVSKLRDENEV-----LRRNLE 914
Cdd:pfam18971  489 --EKNVTLQGSLKHDgvmFVDYSNFKYTNASKNPNkgVGATNGvSHLEAG--FNKVA--VFNLPDLNNLaitsfVRRNLE 562

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  915 NvqnQMKADYVSLEEHSRRMSTVSQSLKEAqeANAAILADHRQGQEEIVSLHAEIKAQKKELD-TIQECIKLKyaplarl 993
Cdd:pfam18971  563 N---KLTAKGLSLQEANKLIKDFLSSNKEL--AGKALNFNKAVAEAKSTGNYDEVKKAQKDLEkSLRKREHLE------- 630

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  994 EECERKFKaTEKGLKEQLSEQTHKCRQRDEEVKK-GKQENERLRA-----DLAALQKELQDrnalaeeareaeralsgKA 1067
Cdd:pfam18971  631 KEVEKKLE-SKSGNKNKMEAKAQANSQKDEIFALiNKEANRDARAiaytqNLKGIKRELSD-----------------KL 692

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1068 DELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLN----------GTIEQLKEEL 1137
Cdd:pfam18971  693 EKISKDLKDFSKSFDEFKNGKNKDFSKAEETLKALKGSVKDLGINPEWISKVENLNAALNefkngknkdfSKVTQAKSDL 772

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1270530344 1138 RSKQRCLEREQQTVSQLQQLlenqkNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKE 1202
Cdd:pfam18971  773 ENSVKDVIINQKVTDKVDNL-----NQAVSVAKAMGDFSRVEQVLADLKNFSKEQLAQQAQKNED 832
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 119-262 1.73e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 45.72  E-value: 1.73e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  119 LQKLLQY--NCPTEHVDlQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGAD-- 194
Cdd:PHA02874    17 IEKIIKNkgNCINISVD-ETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDts 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  195 ---------------------VNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNL 253
Cdd:PHA02874    96 ilpipciekdmiktildcgidVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKL 175

                          170
                   ....*....|.
gi 1270530344  254 L--KTASENTN 262
Cdd:PHA02874   176 LleKGAYANVK 186
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 168-200 1.80e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.97  E-value: 1.80e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1270530344  168 DGRTPLVLATQMC-RPTICQLLIDRGADVNSRDK 200
Cdd:pfam00023    1 DGNTPLHLAAGRRgNLEIVKLLLSKGADVNARDK 34
Ank_5 pfam13857
Ankyrin repeats (many copies);
89-141 1.93e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.41  E-value: 1.93e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1270530344   89 ILTHG-IDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALH 141
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 807-1048 1.97e-04

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 45.69  E-value: 1.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  807 APEKHEK-ELMGLKSNIAELKKQLSELN------KKCGEGQEKIRALMSENSSLKKTLS--SQYVPA-----KTHEEVK- 871
Cdd:PRK05771     2 APVRMKKvLIVTLKSYKDEVLEALHELGvvhiedLKEELSNERLRKLRSLLTKLSEALDklRSYLPKlnplrEEKKKVSv 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  872 ASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADY-VSLEEHSRRMSTVSQSLKEAQEANAa 950
Cdd:PRK05771    82 KSLEELIKDVEEELEKIEKEIKELEEEISELENEIKELEQEIERLEPWGNFDLdLSLLLGFKYVSVFVGTVPEDKLEEL- 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  951 iladhrqgQEEIVSLHAEIKAQKKELDTI-----QECIKLKYAPLARLEEceRKFKATEKGLkeqLSEQTHKCRQRDEEV 1025
Cdd:PRK05771   161 --------KLESDVENVEYISTDKGYVYVvvvvlKELSDEVEEELKKLGF--ERLELEEEGT---PSELIREIKEELEEI 227

                          250       260
                   ....*....|....*....|...
gi 1270530344 1026 KKgkqENERLRADLAALQKELQD 1048
Cdd:PRK05771   228 EK---ERESLLEELKELAKKYLE 247
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
519-738 2.06e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.06  E-value: 2.06e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  519 KQMQTHFLALKEHLTNeaATGSHRIIEELREQLKDLKG------KYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEE 592
Cdd:COG4913    221 PDTFEAADALVEHFDD--LERAHEALEDAREQIELLEPirelaeRYAAARERLAELEYLRAALRLWFAQRRLELLEAELE 298

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  593 N-----KRLQKECGTCEVELERRGRRVVELEGQLKELGAKLalsvptekfesmKSSLSNDINEKVKRLAEVGRDYESAQG 667
Cdd:COG4913    299 ElraelARLEAELERLEARLDALREELDELEAQIRGNGGDR------------LEQLEREIERLERELEERERRRARLEA 366

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1270530344  668 EIRQLK-------RDLESVRAQ-HIRPEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSL 738
Cdd:COG4913    367 LLAALGlplpasaEEFAALRAEaAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLAL 445
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 927-1167 2.28e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 45.14  E-value: 2.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  927 LEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEeceRKFKATEKG 1006
Cdd:COG4942     29 LEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELR---AELEAQKEE 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1007 LKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREaeralsgKADELSKQLKDLSQKYSDVKS 1086
Cdd:COG4942    106 LAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRA-------DLAELAALRAELEAERAELEA 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1087 EREKLVEEKAKQASEILAAQNLLQKqpvpleqvealkksLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSV 1166
Cdd:COG4942    179 LLAELEEERAALEALKAERQKLLAR--------------LEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTP 244


                   .
gi 1270530344 1167 T 1167
Cdd:COG4942    245 A 245
Ank_5 pfam13857
Ankyrin repeats (many copies);
122-176 2.32e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.41  E-value: 2.32e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1270530344  122 LLQY-NCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLA 176
Cdd:pfam13857    1 LLEHgPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 765-1271 2.34e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 45.72  E-value: 2.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  765 DLNKKLSEATQRYTEKKQEAerlLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKcGEGQEKIR 844
Cdd:COG5185    111 NYEWSADILISLLYLYKSEI---VALKDELIKVEKLDEIADIEASYGEVETGIIKDIFGKLTQELNQNLKK-LEIFGLTL 186

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  845 ALMSENSSLKKTLSSQYVPAK----THEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQM 920
Cdd:COG5185    187 GLLKGISELKKAEPSGTVNSIkeseTGNLGSESTLLEKAKEIINIEEALKGFQDPESELEDLAQTSDKLEKLVEQNTDLR 266

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  921 KADYVSLEEHSRRMStvsqslkeaqEANAAILADHRQGQEEIVSLHAEIKAQKKeldtiQECIKLKYAPLARLEECERKF 1000
Cdd:COG5185    267 LEKLGENAESSKRLN----------ENANNLIKQFENTKEKIAEYTKSIDIKKA-----TESLEEQLAAAEAEQELEESK 331

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1001 KATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRAdlaalqkelqdrnalaeeareaeralsgkadelSKQLKDLSQK 1080
Cdd:COG5185    332 RETETGIQNLTAEIEQGQESLTENLEAIKEEIENIVG---------------------------------EVELSKSSEE 378

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1081 YSDVKSEREKLVEEkakqasEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKqrclEREQQTVSQLQQLLEN 1160
Cdd:COG5185    379 LDSFKDTIESTKES------LDEIPQNQRGYAQEILATLEDTLKAADRQIEELQRQIEQA----TSSNEEVSKLLNELIS 448

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1161 QKNSSVTLAEHLKLKEALEKEVGIMkaslREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVdmsKYKATKNDLET 1240
Cdd:COG5185    449 ELNKVMREADEESQSRLEEAYDEIN----RSVRSKKEDLNEELTQIESRVSTLKATLEKLRAKLER---QLEGVRSKLDQ 521

                          490       500       510
                   ....*....|....*....|....*....|.
gi 1270530344 1241 QISNLNDKLASLNRKYDQACEEKVSAKDEKE 1271
Cdd:COG5185    522 VAESLKDFMRARGYAHILALENLIPASELIQ 552
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 459-1047 2.39e-04

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 45.87  E-value: 2.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  459 DSAKQDRLKFQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRmYESEGKVKQMQTHFLALKEHLTNEAAT 538
Cdd:pfam05483  179 EETRQVYMDLNNNIEKMILAFEELRVQAENARLEMHFKLKEDHEKIQHLEEE-YKKEINDKEKQVSLLLIQITEKENKMK 257

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  539 GSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECgtcEVELERRGRRVVELE 618
Cdd:pfam05483  258 DLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDL---QIATKTICQLTEEKE 334

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  619 GQLKELG-AKLALSVPTEKFESMKSSLSNDINEKVKRLaevgrdyESAQGEIRQLKRDLESVRAQHirpEEHEQLRSRLE 697
Cdd:pfam05483  335 AQMEELNkAKAAHSFVVTEFEATTCSLEELLRTEQQRL-------EKNEDQLKIITMELQKKSSEL---EEMTKFKNNKE 404

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  698 QKSGELGKKVSE---LTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEAT 774
Cdd:pfam05483  405 VELEELKKILAEdekLLDEKKQFEKIAEELKGKEQELIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEK 484

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  775 QRYTEKKQEAERLLAENDKLTKNVSRLEAvfvapekhekELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLK 854
Cdd:pfam05483  485 LKNIELTAHCDKLLLENKELTQEASDMTL----------ELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVR 554

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  855 KTLSSQyvpaktHEEVKASLNSTVEKTNRALLEA-----------------KKRFDDTSQEVSKLRDENEVLRRNLENVQ 917
Cdd:pfam05483  555 EEFIQK------GDEVKCKLDKSEENARSIEYEVlkkekqmkilenkcnnlKKQIENKNKNIEELHQENKALKKKGSAEN 628

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  918 NQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKL----KYAPLARL 993
Cdd:pfam05483  629 KQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEIEDKKISEEKLLEEVEKAKAIADEAVKLQKEIDKrcqhKIAEMVAL 708

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1270530344  994 EECERkfKATEKGLKEQLSE-QTHKCRQRDEEVKKGKQENE--RLRADLAALQKELQ 1047
Cdd:pfam05483  709 MEKHK--HQYDKIIEERDSElGLYKNKEQEQSSAKAALEIElsNIKAELLSLKKQLE 763
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 905-1295 2.40e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 45.50  E-value: 2.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  905 ENEVLRRNLENVQNQMKADYVSLEEHSRRMStvSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIK 984
Cdd:pfam17380  267 ENEFLNQLLHIVQHQKAVSERQQQEKFEKME--QERLRQEKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMAM 344

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  985 LKYAPLARLEECERKfKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAAlqkelqdrnalaeeareaerals 1064
Cdd:pfam17380  345 ERERELERIRQEERK-RELERIRQEEIAMEISRMRELERLQMERQQKNERVRQELEA----------------------- 400

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1065 gkadelskqlkdlSQKYSDVKSEREKLVEEKAKQASEILAAQ-NLLQKQPVPLEQvealkkslngtiEQLKEELRSKQRC 1143
Cdd:pfam17380  401 -------------ARKVKILEEERQRKIQQQKVEMEQIRAEQeEARQREVRRLEE------------ERAREMERVRLEE 455

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1144 LEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETR 1223
Cdd:pfam17380  456 QERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKRKLLEKEMEERQKAIYEEERR 535

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1270530344 1224 EVVDMSKYKATKNDLETQISNlNDKLASLNRKYDQACEEkvsakdEKELLHLSIEQEIRDQKERCDKSLTTI 1295
Cdd:pfam17380  536 REAEEERRKQQEMEERRRIQE-QMRKATEERSRLEAMER------EREMMRQIVESEKARAEYEATTPITTI 600
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 108-188 2.44e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.66  E-value: 2.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  108 HLAAKyGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQL 187
Cdd:PTZ00322    88 QLAAS-GDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166


                   .
gi 1270530344  188 L 188
Cdd:PTZ00322   167 L 167
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 960-1349 2.84e-04

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 45.73  E-value: 2.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  960 EEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADL 1039
Cdd:pfam02463  160 EEAAGSRLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERI 239

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1040 AALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEilaaqnllqkqpvpLEQV 1119
Cdd:pfam02463  240 DLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSE--------------LLKL 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1120 EALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEvgimKASLREKEEESQKK 1199
Cdd:pfam02463  306 ERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEK----LEQLEEELLAKKKL 381

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1200 TKEVSKLQTEVQTTKQALKNLETREVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQ 1279
Cdd:pfam02463  382 ESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLL 461

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1280 EIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQ 1349
Cdd:pfam02463  462 KDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRL 531
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 186-254 3.00e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.27  E-value: 3.00e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1270530344  186 QLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNLL 254
Cdd:PTZ00322    99 RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 680-1225 3.22e-04

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 45.12  E-value: 3.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  680 RAQHIRPEEH-EQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKKS 758
Cdd:pfam05557    1 RAELIESKARlSQLQNEKKQMELEHKRARIELEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALREQAELNRL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  759 HDVNVEDLNKKLSEATQRYTEKKqeaERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGE 838
Cdd:pfam05557   81 KKKYLEALNKKLNEKESQLADAR---EVISCLKNELSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEAEQLRQN 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  839 GQEKIRALMSENSSLKK---TLSSQYVPAKTHEEVKASLNS--TVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNL 913
Cdd:pfam05557  158 LEKQQSSLAEAEQRIKElefEIQSQEQDSEIVKNSKSELARipELEKELERLREHNKHLNENIENKLLLKEEVEDLKRKL 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  914 ENvQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARL 993
Cdd:pfam05557  238 ER-EEKYREEAATLELEKEKLEQELQSWVKLAQDTGLNLRSPEDLSRRIEQLQQREIVLKEENSSLTSSARQLEKARREL 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  994 EECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEareaeralSGKADELSKQ 1073
Cdd:pfam05557  317 EQELAQYLKKIEDLNKKLKRHKALVRRLQRRVLLLTKERDGYRAILESYDKELTMSNYSPQL--------LERIEEAEDM 388

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1074 LKDLSQKYSDVKSEREKLVEEKAKQAS---------EILAAQNLLQKQPVPLEQVEALKKSLNgTIEQLKEELRSKQRCL 1144
Cdd:pfam05557  389 TQKMQAHNEEMEAQLSVAEEELGGYKQqaqtlerelQALRQQESLADPSYSKEEVDSLRRKLE-TLELERQRLREQKNEL 467

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1145 EREQQTVSqLQQLLENQKNSSVTLAEHLKLK---------EALEKEVGIMKASLREKEEESQK-----------KTKEVS 1204
Cdd:pfam05557  468 EMELERRC-LQGDYDPKKTKVLHLSMNPAAEayqqrknqlEKLQAEIERLKRLLKKLEDDLEQvlrlpettstmNFKEVL 546

                          570       580
                   ....*....|....*....|.
gi 1270530344 1205 KLQTEVQTTKqaLKNLETREV 1225
Cdd:pfam05557  547 DLRKELESAE--LKNQRLKEV 565
mukB PRK04863
chromosome partition protein MukB;
449-1267 3.43e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 45.33  E-value: 3.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  449 KELETLRTYYDSAkqDRLKFQNELAHKVAEckalALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLAL 528
Cdd:PRK04863   260 KHLITESTNYVAA--DYMRHANERRVHLEE----ALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDYQAA 333

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  529 KEHLT----------------------NEAATGSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIK--QSEMLVGEFK- 583
Cdd:PRK04863   334 SDHLNlvqtalrqqekieryqadleelEERLEEQNEVVEEADEQQEENEARAEAAEEEVDELKSQLAdyQQALDVQQTRa 413

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  584 ---RDEGRLVEENKRLqkeCGTCEVELERRGRRVVELEGQLKELGAKLaLSVPTekfesmKSSLSNDINEK-------VK 653
Cdd:PRK04863   414 iqyQQAVQALERAKQL---CGLPDLTADNAEDWLEEFQAKEQEATEEL-LSLEQ------KLSVAQAAHSQfeqayqlVR 483

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  654 RLA-EVGRdyESAQGEIRQLKRDLESVRAQhirPEEHEQLRSRLeqksgelgkkvseltlknQTLQKDVEKLHADNKLLN 732
Cdd:PRK04863   484 KIAgEVSR--SEAWDVARELLRRLREQRHL---AEQLQQLRMRL------------------SELEQRLRQQQRAERLLA 540

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  733 Q--QVHSLTVEMKTRYvplrvsEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKN----------VSR 800
Cdd:PRK04863   541 EfcKRLGKNLDDEDEL------EQLQEELEARLESLSESVSEARERRMALRQQLEQLQARIQRLAARapawlaaqdaLAR 614

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  801 LEAVFvaPEK----------------HEKELM----GLKSNIAELKKQLSELNKKCGEGQEKIRALMS-----------E 849
Cdd:PRK04863   615 LREQS--GEEfedsqdvteymqqlleRERELTverdELAARKQALDEEIERLSQPGGSEDPRLNALAErfggvllseiyD 692

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  850 NSSLKKT--LSSQYVPAKtHEEVKASLNSTVEKtnralLEAkkrFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSL 927
Cdd:PRK04863   693 DVSLEDApyFSALYGPAR-HAIVVPDLSDAAEQ-----LAG---LEDCPEDLYLIEGDPDSFDDSVFSVEELEKAVVVKI 763

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  928 EEHSRRMS---TVSQSLKEAQEANAAILadhRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYA----------PLARLE 994
Cdd:PRK04863   764 ADRQWRYSrfpEVPLFGRAAREKRIEQL---RAEREELAERYATLSFDVQKLQRLHQAFSRFIGshlavafeadPEAELR 840

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  995 ECERKFKATEKGLkEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKE-LQDRnalaeeareaeralsgkADELSKQ 1073
Cdd:PRK04863   841 QLNRRRVELERAL-ADHESQEQQQRSQLEQAKEGLSALNRLLPRLNLLADEtLADR-----------------VEEIREQ 902

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1074 LKDLSQKYSDVKSEreklveekAKQASEILAAQNLLQKQPvplEQVEALKKSLngtiEQLKEELR-SKQRCL-------E 1145
Cdd:PRK04863   903 LDEAEEAKRFVQQH--------GNALAQLEPIVSVLQSDP---EQFEQLKQDY----QQAQQTQRdAKQQAFaltevvqR 967

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1146 REQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVgimKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLEtREV 1225
Cdd:PRK04863   968 RAHFSYEDAAEMLAKNSDLNEKLRQRLEQAEQERTRA---REQLRQAQAQLAQYNQVLASLKSSYDAKRQMLQELK-QEL 1043

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1270530344 1226 VDM-----------------------SKYKATKNDLETQIS-------NLNDKLASLNRKYDQACEEKVSAK 1267
Cdd:PRK04863  1044 QDLgvpadsgaeerararrdelharlSANRSRRNQLEKQLTfceaemdNLTKKLRKLERDYHEMREQVVNAK 1115
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1030-1374 3.44e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 45.29  E-value: 3.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1030 QENERLRADLAALQKELQDRnalaeeareaeralsgkADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQnlL 1109
Cdd:COG4913    606 FDNRAKLAALEAELAELEEE-----------------LAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVAS--A 666

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1110 QKQpvpLEQVEALKKSL---NGTIEQLK---EELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLK--LKEALEKE 1181
Cdd:COG4913    667 ERE---IAELEAELERLdasSDDLAALEeqlEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQdrLEAAEDLA 743

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1182 VGIMKASLREK--EEESQKKTKEVSK-LQTEVQTTKQALKNLETREVVDMSKYKAT----KNDLETQISNLNDKLASLNR 1254
Cdd:COG4913    744 RLELRALLEERfaAALGDAVERELREnLEERIDALRARLNRAEEELERAMRAFNREwpaeTADLDADLESLPEYLALLDR 823

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1255 KYDQACEEKVsaKDEKELLHLSIEQEIRDqkercdkslttimeLQQRIQESAKQIEakdnkitellndvERLKQaLN-GL 1333
Cdd:COG4913    824 LEEDGLPEYE--ERFKELLNENSIEFVAD--------------LLSKLRRAIREIK-------------ERIDP-LNdSL 873

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 1270530344 1334 SQLTYSSGS-----PTKRQSQLVDTLQQRVRDLQQQLADADRQHQE 1374
Cdd:COG4913    874 KRIPFGPGRylrleARPRPDPEVREFRQELRAVTSGASLFDEELSE 919
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 135-166 3.55e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.19  E-value: 3.55e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1270530344  135 QGRTALHDAA-MADCPSSIQLLCDHGASVNAKD 166
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 764-999 4.44e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 44.37  E-value: 4.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  764 EDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAvfvapekhekelmglksNIAELKKQLSELNKKCGEGQEKI 843
Cdd:COG4942     23 AEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALER-----------------RIAALARRIRALEQELAALEAEL 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  844 RALMSENSSLKKTLSSQyvpakthEEVKASLNSTVEKTNR----ALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQ 919
Cdd:COG4942     86 AELEKEIAELRAELEAQ-------KEELAELLRALYRLGRqpplALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRAD 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  920 MKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERK 999
Cdd:COG4942    159 LAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAA 238
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
447-851 4.67e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 44.76  E-value: 4.67e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  447 LKKELETLRTYYDSAKQDRLKFQNELAHKVAECKALALECERvkEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFL 526
Cdd:COG4717     93 LQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQEL--EALEAELAELPERLEELEERLEELRELEEELEELEA 170

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  527 ALKEhLTNEAATGSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKEcgtceve 606
Cdd:COG4717    171 ELAE-LQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALE------- 242

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  607 lerrgRRVVELEGQLKELGAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQH-IR 685
Cdd:COG4717    243 -----ERLKEARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEeLE 317

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  686 PEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSltvemktryvpLRVSEEMKKSHDVNVED 765
Cdd:COG4717    318 EEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELE-----------QEIAALLAEAGVEDEEE 386

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  766 LNKKLsEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVaPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRA 845
Cdd:COG4717    387 LRAAL-EQAEEYQELKEELEELEEQLEELLGELEELLEALD-EEELEEELEELEEELEELEEELEELREELAELEAELEQ 464


                   ....*.
gi 1270530344  846 LMSENS 851
Cdd:COG4717    465 LEEDGE 470
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
488-703 5.13e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 44.37  E-value: 5.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  488 RVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQmqthflalkehltneaatgshriIEELREQLKDLKGKYEGASAEVGK 567
Cdd:COG4717     64 RKPELNLKELKELEEELKEAEEKEEEYAELQEE-----------------------LEELEEELEELEAELEELREELEK 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  568 LRsQIKQSEMLVGEFKRDEGRLVEENKRLQkecgtcevELERRGRRVVELEGQLKELGAKLAlsvptEKFESMKSSLSND 647
Cdd:COG4717    121 LE-KLLQLLPLYQELEALEAELAELPERLE--------ELEERLEELRELEEELEELEAELA-----ELQEELEELLEQL 186

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1270530344  648 INEKVKRLAEVGRDYESAQGEIRQLKRDLESVRaqhirpEEHEQLRSRLEQKSGEL 703
Cdd:COG4717    187 SLATEEELQDLAEELEELQQRLAELEEELEEAQ------EELEELEEELEQLENEL 236
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 81-202 5.26e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 44.49  E-value: 5.26e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   81 GNLECLNAILTHgiDVATRDSAGRNALHLAAKYGH-------ALCLQKLLQYNCPTEHVD-------LQGRTALHDAAMA 146
Cdd:cd21882      6 GLLECLRWYLTD--SAYQRGATGKTCLHKAALNLNdgvneaiMLLLEAAPDSGNPKELVNapctdefYQGQTALHIAIEN 83

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1270530344  147 DCPSSIQLLCDHGASVNAKDID-------------GRTPLVLATQMCRPTICQLLIDRGADVNSRDKQN 202
Cdd:cd21882     84 RNLNLVRLLVENGADVSARATGrffrkspgnlfyfGELPLSLAACTNQEEIVRLLLENGAQPAALEAQD 152
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1072-1333 5.46e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 44.67  E-value: 5.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1072 KQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPL-EQVEALKKSLNgTIEQLKEELRSKQRCLEREQQT 1150
Cdd:PRK03918   175 KRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELrEELEKLEKEVK-ELEELKEEIEELEKELESLEGS 253

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1151 VSQLQQLLENQKNSSVTLAEHLKLKEALEKEVgimkaslrekeEESQKKTKEVSKLQTEVQTTKQALKNLETREvvdmSK 1230
Cdd:PRK03918   254 KRKLEEKIRELEERIEELKKEIEELEEKVKEL-----------KELKEKAEEYIKLSEFYEEYLDELREIEKRL----SR 318

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1231 YKATKNDLETQISNLNDKLASLN--RKYDQACEEKVSAKDEKELLHLSIEQeIRDQKERCDKSLT---------TIMELQ 1299
Cdd:PRK03918   319 LEEEINGIEERIKELEEKEERLEelKKKLKELEKRLEELEERHELYEEAKA-KKEELERLKKRLTgltpeklekELEELE 397

                          250       260       270
                   ....*....|....*....|....*....|....
gi 1270530344 1300 QRIQESAKQIEAKDNKITELLNDVERLKQALNGL 1333
Cdd:PRK03918   398 KAKEEIEEEISKITARIGELKKEIKELKKAIEEL 431
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 471-1158 6.00e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 44.44  E-value: 6.00e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  471 ELAHKVAECKALA-LECERVKEDSDEQ-IKQLEDALKdvqkRMYESEGKVKQMQThflaLKEHLTNEAATGSHRIIEELR 548
Cdd:pfam12128  222 QVEHWIRDIQAIAgIMKIRPEFTKLQQeFNTLESAEL----RLSHLHFGYKSDET----LIASRQEERQETSAELNQLLR 293

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  549 EQLKDLKGKYEGASAEVGKLRSQIKQsemlvgefKRDEGRLVEENKR--LQKECGTCEVELERRGRRVVELEGQLKELGA 626
Cdd:pfam12128  294 TLDDQWKEKRDELNGELSAADAAVAK--------DRSELEALEDQHGafLDADIETAAADQEQLPSWQSELENLEERLKA 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  627 KL-ALSVPTEKFESMKSSLSNDINEKVKRLAE--------VGRDYESAQGEIRQLKRDLESVRAQHIRP--EEHEQLRSR 695
Cdd:pfam12128  366 LTgKHQDVTAKYNRRRSKIKEQNNRDIAGIKDklakireaRDRQLAVAEDDLQALESELREQLEAGKLEfnEEEYRLKSR 445

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  696 LEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKL--LNQQVHSLTVEmktryvpLRVSEEMKKSHDVNVEDLNKKLSEA 773
Cdd:pfam12128  446 LGELKLRLNQATATPELLLQLENFDERIERAREEQeaANAEVERLQSE-------LRQARKRRDQASEALRQASRRLEER 518

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  774 TQRYTEKKQ----EAERLLA--------ENDKLTKNVSR--LEAVFVAPEKHEKELMGlKSNIAELKKQLSELNKKCGEG 839
Cdd:pfam12128  519 QSALDELELqlfpQAGTLLHflrkeapdWEQSIGKVISPelLHRTDLDPEVWDGSVGG-ELNLYGVKLDLKRIDVPEWAA 597

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  840 QEKirALMSENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVL---------- 909
Cdd:pfam12128  598 SEE--ELRERLDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTALKNARLDLRRLFDEKQSEkdkknkalae 675

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  910 --------RRNLENVQNQMKADYVSLEEHSRRMS-----TVSQSLKEAQEANAAILADHRQGQE-EIVSLHAEIKAQKKE 975
Cdd:pfam12128  676 rkdsanerLNSLEAQLKQLDKKHQAWLEEQKEQKreartEKQAYWQVVEGALDAQLALLKAAIAaRRSGAKAELKALETW 755

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  976 LDT--------------IQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKcrqRDEEVKKGKQENERLRADLAA 1041
Cdd:pfam12128  756 YKRdlaslgvdpdviakLKREIRTLERKIERIAVRRQEVLRYFDWYQETWLQRRPR---LATQLSNIERAISELQQQLAR 832

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1042 LQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREklVEEKAKQASEILAA-QNLLQKQPVPLEQVE 1120
Cdd:pfam12128  833 LIADTKLRRAKLEMERKASEKQQVRLSENLRGLRCEMSKLATLKEDAN--SEQAQGSIGERLAQlEDLKLKRDYLSESVK 910

                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1270530344 1121 ALKKSLNGTI------------EQLKEELRS---KQRCLEREQQTVSQLQQLL 1158
Cdd:pfam12128  911 KYVEHFKNVIadhsgsglaetwESLREEDHYqndKGIRLLDYRKLVPYLEQWF 963
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 595-1224 6.15e-04

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 44.40  E-value: 6.15e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  595 RLQKECGTCEVELERRGRRVVELEGQLKELGAKLA------------LSVPTEKF---ESMKSSLSNdineKVKRLAEVG 659
Cdd:pfam01576    2 RQEEEMQAKEEELQKVKERQQKAESELKELEKKHQqlceeknalqeqLQAETELCaeaEEMRARLAA----RKQELEEIL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  660 RDYESAQGEIRQLKRDLESVR---AQHIRP-----EEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLL 731
Cdd:pfam01576   78 HELESRLEEEEERSQQLQNEKkkmQQHIQDleeqlDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKERKLL 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  732 NQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLseatqryteKKQEAERLlaendKLTKNVSRLEAvfvapekh 811
Cdd:pfam01576  158 EERISEFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERL---------KKEEKGRQ-----ELEKAKRKLEG-------- 215

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  812 ekELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMS--------ENSSLKKTLSSQYVPAKTHEEVKAslnstvEKTNR 883
Cdd:pfam01576  216 --ESTDLQEQIAELQAQIAELRAQLAKKEEELQAALArleeetaqKNNALKKIRELEAQISELQEDLES------ERAAR 287

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  884 ALLEAKKRfddtsqevsKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQgqeeiv 963
Cdd:pfam01576  288 NKAEKQRR---------DLGEELEALKTELEDTLDTTAAQQELRSKREQEVTELKKALEEETRSHEAQLQEMRQ------ 352

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  964 slhaeikAQKKELDTIQEciklkyaplaRLEECERKFKATEKGlKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQ 1043
Cdd:pfam01576  353 -------KHTQALEELTE----------QLEQAKRNKANLEKA-KQALESENAELQAELRTLQQAKQDSEHKRKKLEGQL 414

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1044 KELQDRNALAEEAREAERALSGKadeLSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQ---KQPVPL-EQV 1119
Cdd:pfam01576  415 QELQARLSESERQRAELAEKLSK---LQSELESVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQeetRQKLNLsTRL 491

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1120 EALKKSLNGTIEQLKEELRSKQRcLEREQQTV-SQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQK 1198
Cdd:pfam01576  492 RQLEDERNSLQEQLEEEEEAKRN-VERQLSTLqAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDK 570

                          650       660       670
                   ....*....|....*....|....*....|...
gi 1270530344 1199 KTKEVSKLQTE-------VQTTKQALKNLETRE 1224
Cdd:pfam01576  571 LEKTKNRLQQElddllvdLDHQRQLVSNLEKKQ 603
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1138-1333 6.48e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.99  E-value: 6.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1138 RSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQAL 1217
Cdd:COG1579      3 PEDLRALLDLQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQL 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1218 KNLET-REVVDMSK----YKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERcdksl 1292
Cdd:COG1579     83 GNVRNnKEYEALQKeiesLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAE----- 157

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1270530344 1293 ttIMELQQRIQESAKQIEAkdnkitELLNDVERLKQALNGL 1333
Cdd:COG1579    158 --LEELEAEREELAAKIPP------ELLALYERIRKRKNGL 190
46 PHA02562
endonuclease subunit; Provisional
 1128-1330 6.63e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 44.23  E-value: 6.63e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1128 GTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQknssvtLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQ 1207
Cdd:PHA02562   163 SVLSEMDKLNKDKIRELNQQIQTLDMKIDHIQQQ------IKTYNKNIEEQRKKNGENIARKQNKYDELVEEAKTIKAEI 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1208 TEVQTtkqALKNLetreVVDMSKYKATKNDLETQISNLNDKLASLNRKYD--------QACEEKVSAKDEKEllhlsieQ 1279
Cdd:PHA02562   237 EELTD---ELLNL----VMDIEDPSAALNKLNTAAAKIKSKIEQFQKVIKmyekggvcPTCTQQISEGPDRI-------T 302

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1270530344 1280 EIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQAL 1330
Cdd:PHA02562   303 KIKDKLKELQHSLEKLDTAIDELEEIMDEFNEQSKKLLELKNKISTNKQSL 353
PRK11281 PRK11281
mechanosensitive channel MscK;
1234-1371 6.70e-04

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 44.52  E-value: 6.70e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1234 TKNDLETQISNLNDklaslnRKYDQAcEEKVSAKD-EKELLHLsieQEIRDQKERCDkslttimELQQRIQESakqieak 1312
Cdd:PRK11281    37 TEADVQAQLDALNK------QKLLEA-EDKLVQQDlEQTLALL---DKIDRQKEETE-------QLKQQLAQA------- 92

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1270530344 1313 DNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQrVRDLQQQLADADRQ 1371
Cdd:PRK11281    93 PAKLRQAQAELEALKDDNDEETRETLSTLSLRQLESRLAQTLDQ-LQNAQNDLAEYNSQ 150
PRK11281 PRK11281
mechanosensitive channel MscK;
819-1039 6.82e-04

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 44.13  E-value: 6.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  819 KSNIAELKKQLSELNKKCGEGQEKIRALMSEN-SSLKKTLSSQYVPaktheevkaSLNSTVEKTNRALLEAKKRFDDT-S 896
Cdd:PRK11281    79 KEETEQLKQQLAQAPAKLRQAQAELEALKDDNdEETRETLSTLSLR---------QLESRLAQTLDQLQNAQNDLAEYnS 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  897 QEVSklrdenevLRRNLENVQNQMKADyvsleehSRRMSTVSQSLKEAQEANAAILADHRQG-QEEIVSLHAEIKAQKKE 975
Cdd:PRK11281   150 QLVS--------LQTQPERAQAALYAN-------SQRLQQIRNLLKGGKVGGKALRPSQRVLlQAEQALLNAQNDLQRKS 214

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  976 L---DTIQECIKLKY----APLARLEE---------CERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADL 1039
Cdd:PRK11281   215 LegnTQLQDLLQKQRdyltARIQRLEHqlqllqeaiNSKRLTLSEKTVQEAQSQDEAARIQANPLVAQELEINLQLSQRL 294
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
692-921 6.82e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 44.24  E-value: 6.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  692 LRSRLEQKSGELGKKVSELTLKNQTLQKDVEKlhADNKLlnqqvhsltVEMKTRYVPLRVSEEMKkSHDVNVEDLNKKLS 771
Cdd:COG3206    162 LEQNLELRREEARKALEFLEEQLPELRKELEE--AEAAL---------EEFRQKNGLVDLSEEAK-LLLQQLSELESQLA 229

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  772 EATQRYTEKKQEAERLlaeNDKLTKNVSRLEAVFVAPEkhekeLMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENS 851
Cdd:COG3206    230 EARAELAEAEARLAAL---RAQLGSGPDALPELLQSPV-----IQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIA 301

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1270530344  852 SLKKTLSSQYVPAKTHEEVK-ASLNSTVEKTNRALLEAKKRFD---DTSQEVSKLRDENEVLRRNLENVQNQMK 921
Cdd:COG3206    302 ALRAQLQQEAQRILASLEAElEALQAREASLQAQLAQLEARLAelpELEAELRRLEREVEVARELYESLLQRLE 375
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1019-1235 6.94e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 43.67  E-value: 6.94e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1019 RQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYsdvkSEREKLVEEKAKQ 1098
Cdd:COG3883     19 QAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEI----EERREELGERARA 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1099 ASE----------ILAAQN---LLQKQPVpLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSS 1165
Cdd:COG3883     95 LYRsggsvsyldvLLGSESfsdFLDRLSA-LSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAEL 173

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1270530344 1166 VT-LAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVDMSKYKATK 1235
Cdd:COG3883    174 EAqQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 244
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 767-1321 8.62e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 44.27  E-value: 8.62e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  767 NKKLSEATQRYTEKK-QEAERLLAENDKLTKNVSRLE-AVFVAPEKHEKELMGLKSNIAELKKQLSEL-------NKKCG 837
Cdd:TIGR01612  524 NIIGFDIDQNIKAKLyKEIEAGLKESYELAKNWKKLIhEIKKELEEENEDSIHLEKEIKDLFDKYLEIddeiiyiNKLKL 603

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  838 EGQEKIRALMSENSSLKKTLSSQYV---------------PAKTHEEVKA--SLNSTVEKTNRALLEAKkrFDDTSQEVS 900
Cdd:TIGR01612  604 ELKEKIKNISDKNEYIKKAIDLKKIiennnayidelakisPYQVPEHLKNkdKIYSTIKSELSKIYEDD--IDALYNELS 681

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  901 KLRDENEVlrrnlENVQNQMKadyvsLEEHSRRMSTVSQSLKEAqeanaailadhrqgQEEIVSLH-AEIKAQKKEL-DT 978
Cdd:TIGR01612  682 SIVKENAI-----DNTEDKAK-----LDDLKSKIDKEYDKIQNM--------------ETATVELHlSNIENKKNELlDI 737

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  979 IQECIKLKYAPLAR-LEECERKFKATEKGLKEQLS------EQTHKCRQRDEEVKkgKQENERLRADlaalQKELQDRNA 1051
Cdd:TIGR01612  738 IVEIKKHIHGEINKdLNKILEDFKNKEKELSNKINdyakekDELNKYKSKISEIK--NHYNDQINID----NIKDEDAKQ 811

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1052 LAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLV------EEKAKQASEILAAQNLLQKQPVPLEQVEALKKS 1125
Cdd:TIGR01612  812 NYDKSKEYIKTISIKEDEIFKIINEMKFMKDDFLNKVDKFInfenncKEKIDSEHEQFAELTNKIKAEISDDKLNDYEKK 891

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1126 LNGTIEQLKEELRSkqrcLEREQQTVSQLQ------QLLENQKNSSVTL-AEHLKLKEALEKEVGIMKASlreKEEESQK 1198
Cdd:TIGR01612  892 FNDSKSLINEINKS----IEEEYQNINTLKkvdeyiKICENTKESIEKFhNKQNILKEILNKNIDTIKES---NLIEKSY 964

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1199 KTKEVSKLQTEVQTTKQALKNLEtrevvdMSKYKATKNDLETQISNLNDKLASL--NRKYDQAceekvsakDEKELLHLS 1276
Cdd:TIGR01612  965 KDKFDNTLIDKINELDKAFKDAS------LNDYEAKNNELIKYFNDLKANLGKNkeNMLYHQF--------DEKEKATND 1030

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*.
gi 1270530344 1277 IEQEIRDqkerCDKSLTTI-MELQQRIQESAKQIEAKDNKITELLN 1321
Cdd:TIGR01612 1031 IEQKIED----ANKNIPNIeIAIHTSIYNIIDEIEKEIGKNIELLN 1072
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 1066-1337 9.46e-04

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 44.05  E-value: 9.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1066 KADELSKQLKDLSQKYSDVKSEREKLVEEKAKQAS--EILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRC 1143
Cdd:PTZ00440   451 KINELKKSINQLKTLISIMKSFYDLIISEKDSMDSkeKKESSDSNYQEKVDELLQIINSIKEKNNIVNNNFKNIEDYYIT 530

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1144 LEREQQTVSQLQQLLENQKNSSVTLAEHlklkealEKEVGIMKASLREK---EEESQKKTKEVSKLQTEVQTTKQALKNL 1220
Cdd:PTZ00440   531 IEGLKNEIEGLIELIKYYLQSIETLIKD-------EKLKRSMKNDIKNKikyIEENVDHIKDIISLNDEIDNIIQQIEEL 603

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1221 ETREVVDMSKYKATKNDLETQISNLNDK------------LASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERC 1288
Cdd:PTZ00440   604 INEALFNKEKFINEKNDLQEKVKYILNKfykgdlqelldeLSHFLDDHKYLYHEAKSKEDLQTLLNTSKNEYEKLEFMKS 683

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 1270530344 1289 DKSLTTIMELQqriQESAKQIEAKDNKITELLNDVErlKQALNGLSQLT 1337
Cdd:PTZ00440   684 DNIDNIIKNLK---KELQNLLSLKENIIKKQLNNIE--QDISNSLNQYT 727
PRK01156 PRK01156
chromosome segregation protein; Provisional
 720-1272 1.01e-03

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 43.74  E-value: 1.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  720 DVEKLHADNKLLNQQVHSLTVEMKTryvpLRVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVS 799
Cdd:PRK01156   160 EINSLERNYDKLKDVIDMLRAEISN----IDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYN 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  800 RLEAVFVAPEKHEKELMGLKSNIAELKKQLS---ELNKKCGEGQEKIRALMSENSSLKKTLSSQYVPAKTH--------E 868
Cdd:PRK01156   236 NLKSALNELSSLEDMKNRYESEIKTAESDLSmelEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDienkkqilS 315

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  869 EVKASLN---------STVEKTNRALLEAKKRFDDTSQEVSKLR---DENEVLRRNLENVQNQMKADYVSLEEHSRRMST 936
Cdd:PRK01156   316 NIDAEINkyhaiikklSVLQKDYNDYIKKKSRYDDLNNQILELEgyeMDYNSYLKSIESLKKKIEEYSKNIERMSAFISE 395

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  937 VSQSLKEAQEANAAILADHRQGQEEI----VSLHAEIKAQKKELDTIQECIKL----KYAPLARLEECERKFKATEKGLK 1008
Cdd:PRK01156   396 ILKIQEIDPDAIKKELNEINVKLQDIsskvSSLNQRIRALRENLDELSRNMEMlngqSVCPVCGTTLGEEKSNHIINHYN 475

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1009 EQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSER 1088
Cdd:PRK01156   476 EKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEYLESEEINKSINEYNKIESARADLEDIKIKINELKDKHDKYEEIKNRY 555

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1089 EKL----VEEKAKQASEILAAQNLLQKQPVPlEQVEALKKSLNGTIEQLKE---ELRSKQRCLEREQQTVSQLQQLLENQ 1161
Cdd:PRK01156   556 KSLkledLDSKRTSWLNALAVISLIDIETNR-SRSNEIKKQLNDLESRLQEieiGFPDDKSYIDKSIREIENEANNLNNK 634

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1162 KNssvtLAEHLK-LKEALEKEVGIMKASLREKEEeSQKKTKEVSKLQTEVQTTKQALKNLETREVVDMSKYKATKNDLET 1240
Cdd:PRK01156   635 YN----EIQENKiLIEKLRGKIDNYKKQIAEIDS-IIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIEILRT 709

                          570       580       590
                   ....*....|....*....|....*....|..
gi 1270530344 1241 QISNLNDKLASLNRKYDQACEEKVSAKDEKEL 1272
Cdd:PRK01156   710 RINELSDRINDINETLESMKKIKKAIGDLKRL 741
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
772-1256 1.02e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 43.60  E-value: 1.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  772 EATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELnkkcgegQEKIRALmsens 851
Cdd:COG4717     54 EADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEEL-------REELEKL----- 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  852 slkKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAkkrfddtsQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHS 931
Cdd:COG4717    122 ---EKLLQLLPLYQELEALEAELAELPERLEELEERL--------EELRELEEELEELEAELAELQEELEELLEQLSLAT 190

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  932 RrmstvsQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQEcIKLKYAPLARLEECERKFKATekGLKEQL 1011
Cdd:COG4717    191 E------EELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLEN-ELEAAALEERLKEARLLLLIA--AALLAL 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1012 SEQTHKCRQRDEEVKKGKQENERLRADLAA-LQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREK 1090
Cdd:COG4717    262 LGLGGSLLSLILTIAGVLFLVLGLLALLFLlLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLE 341

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1091 L---VEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQtVSQLQQLLENQKNSSVT 1167
Cdd:COG4717    342 LldrIEELQELLREAEELEEELQLEELEQEIAALLAEAGVEDEEELRAALEQAEEYQELKEE-LEELEEQLEELLGELEE 420

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1168 LAEHLKLKEALEKevgimkasLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVDmskykatknDLETQISNLND 1247
Cdd:COG4717    421 LLEALDEEELEEE--------LEELEEELEELEEELEELREELAELEAELEQLEEDGELA---------ELLQELEELKA 483


                   ....*....
gi 1270530344 1248 KLASLNRKY 1256
Cdd:COG4717    484 ELRELAEEW 492
PHA02798 PHA02798
ankyrin-like protein; Provisional
 152-228 1.03e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 43.28  E-value: 1.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  152 IQLLCDHGASVNAKDIDGRTPL--VLATQ-MCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCR---DAVEVLVKNG 225
Cdd:PHA02798    92 VKILIENGADINKKNSDGETPLycLLSNGyINNLEILLFMIENGADTTLLDKDGFTMLQVYLQSNHHidiEIIKLLLEKG 171


                   ...
gi 1270530344  226 ADL 228
Cdd:PHA02798   172 VDI 174
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 1065-1273 1.13e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 43.38  E-value: 1.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1065 GKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQasEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSkqrcL 1144
Cdd:PRK05771    46 RKLRSLLTKLSEALDKLRSYLPKLNPLREEKKKV--SVKSLEELIKDVEEELEKIEKEIKELEEEISELENEIKE----L 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1145 EREQQTVSQLQQL---LENQKNSSVTLAEHLKLKEALEKEVGImKASLREKEEESQKKTKE-----VSKLQTEVQTT--- 1213
Cdd:PRK05771   120 EQEIERLEPWGNFdldLSLLLGFKYVSVFVGTVPEDKLEELKL-ESDVENVEYISTDKGYVyvvvvVLKELSDEVEEelk 198

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1270530344 1214 KQALKNLETREVVD----MSKYKATKNDLETQISNLNDKLASLNRKYDQ---ACEEKVSA-KDEKELL 1273
Cdd:PRK05771   199 KLGFERLELEEEGTpselIREIKEELEEIEKERESLLEELKELAKKYLEellALYEYLEIeLERAEAL 266
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 443-683 1.19e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.39  E-value: 1.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  443 ENEILKKELETLRTYYDSAKQDRLKFQNELAHKVAEckalALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQ 522
Cdd:COG1196    261 ELAELEAELEELRLELEELELELEEAQAEEYELLAE----LARLEQDIARLEERRRELEERLEELEEELAELEEELEELE 336

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  523 THFLALKEHLTNEAAtgshrIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGT 602
Cdd:COG1196    337 EELEELEEELEEAEE-----ELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEA 411

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  603 CEVELERRGRRVVELEGQLKEL-GAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRA 681
Cdd:COG1196    412 LLERLERLEEELEELEEALAELeEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAA 491


                   ..
gi 1270530344  682 QH 683
Cdd:COG1196    492 RL 493
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 872-1069 1.22e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 42.89  E-value: 1.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  872 ASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTV-----SQSLKEAQE 946
Cdd:COG3883     40 DALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARALYRSGGSVSYLdvllgSESFSDFLD 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  947 ANAAILADHRQGQEEIvslhAEIKAQKKELDTIQECIKLKyapLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVK 1026
Cdd:COG3883    120 RLSALSKIADADADLL----EELKADKAELEAKKAELEAK---LAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEA 192

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1270530344 1027 KGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADE 1069
Cdd:COG3883    193 AAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAA 235
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 292-1046 1.51e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 43.11  E-value: 1.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  292 QREQRE-PHSFQDLEIENEDLREKLRKIQQEQRILLDKVNGLQLQLN--EEVMVADDLE------------------SER 350
Cdd:TIGR00606  311 QRTVREkERELVDCQRELEKLNKERRLLNQEKTELLVEQGRLQLQADrhQEHIRARDSLiqslatrleldgfergpfSER 390

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  351 EkLKSLLAAKEKQHEESLRTIEALKNRFK-----------YFESDHPGPGSYPSNRKEDMLHKQGQM--YTTEPQCASPG 417
Cdd:TIGR00606  391 Q-IKNFHTLVIERQEDEAKTAAQLCADLQskerlkqeqadEIRDEKKGLGRTIELKKEILEKKQEELkfVIKELQQLEGS 469

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  418 IPPHMHSRSMLRPLELSLPSQTSYSENEILKKELETLRTYYDSAKQDRLKFQNELAHKVAECKALA--LECERVKEDSDE 495
Cdd:TIGR00606  470 SDRILELDQELRKAERELSKAEKNSLTETLKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTqmEMLTKDKMDKDE 549

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  496 QI-----------------------------------KQLEDALKDVQKRMYESEgkvkQMQTHFLALKEHLTNEAATGS 540
Cdd:TIGR00606  550 QIrkiksrhsdeltsllgyfpnkkqledwlhskskeiNQTRDRLAKLNKELASLE----QNKNHINNELESKEEQLSSYE 625

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  541 HRIIEELREQlkDLKGKYEGASAEVGKLRsqiKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEvelerrgrRVVELEGQ 620
Cdd:TIGR00606  626 DKLFDVCGSQ--DEESDLERLKEEIEKSS---KQRAMLAGATAVYSQFITQLTDENQSCCPVCQ--------RVFQTEAE 692

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  621 LKELGAKL---ALSVPTEkfesmKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIR-PEEHEQLRSRL 696
Cdd:TIGR00606  693 LQEFISDLqskLRLAPDK-----LKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKvNRDIQRLKNDI 767

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  697 EQKSGELGKKVSELTLKnQTLQKDVEKLhadnkllnQQVHSLTVEMKTRYVPLrVSEEMKKSHDVNVEDLNKKLSEATQR 776
Cdd:TIGR00606  768 EEQETLLGTIMPEEESA-KVCLTDVTIM--------ERFQMELKDVERKIAQQ-AAKLQGSDLDRTVQQVNQEKQEKQHE 837

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  777 YTEKKQEAErllaENDKLTknvsrleavfvapEKHEKELMGLKSNIAELKK---QLSELNKKCGEGQEKIRALMSENSSL 853
Cdd:TIGR00606  838 LDTVVSKIE----LNRKLI-------------QDQQEQIQHLKSKTNELKSeklQIGTNLQRRQQFEEQLVELSTEVQSL 900

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  854 KKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSrr 933
Cdd:TIGR00606  901 IREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGKDDYLKQKETE-- 978

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  934 MSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKyaplarleECERKFKATEKGLKE-QLS 1012
Cdd:TIGR00606  979 LNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRENELK--------EVEEELKQHLKEMGQmQVL 1050

                          810       820       830
                   ....*....|....*....|....*....|....
gi 1270530344 1013 EQTHKCRQRDEEVKKGKQENERLRADLAALQKEL 1046
Cdd:TIGR00606 1051 QMKQEHQKLEENIDLIKRNHVLALGRQKGYEKEI 1084
Gp58 pfam07902
gp58-like protein; Sequences found in this family are derived from a number of bacteriophage ...
 1069-1358 1.98e-03

gp58-like protein; Sequences found in this family are derived from a number of bacteriophage and prophage proteins. They are similar to gp58, a minor structural protein of Lactococcus delbrueckii bacteriophage LL-H.


Pssm-ID: 369586 [Multi-domain]  Cd Length: 594  Bit Score: 42.63  E-value: 1.98e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1069 ELSKQLKDL--SQKYSDVKSEREKLVEEKAKQ--ASEIL-AAQNLLQKQPVPLEQVEALkksLNGTIEQLKEELRSKQRC 1143
Cdd:pfam07902   89 ELNLELTDTknSNLWSKIKLNNNGMLREYHNDtiKTEIVeSAEGIATRISEDTDKKLAL---INETISGIRREYQDADRQ 165

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1144 LERE-QQTVSQLQQLLENQKNssvtlaehlklkeALEKEVGIMKASLrekeeeSQKKTKEVSKLQTEVQTTKQAlknlet 1222
Cdd:pfam07902  166 LSSSyQAGIEGLKATMASDKI-------------GLQAEIQASAQGL------SQRYDNEIRKLSAKITTTSSG------ 220

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1223 revvdmskykaTKNDLETQISNLNDKLASLNRKYDQACEEKVSA-KDEKELLHLSIEQEIRDQKERCDKSLTTIMELQQR 1301
Cdd:pfam07902  221 -----------TTEAYESKLDDLRAEFTRSNQGMRTELESKISGlQSTQQSTAYQISQEISNREGAVSRVQQDLDSYQRR 289

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1270530344 1302 IQESAKQIEAkdnkitellndverLKQALNGL-SQLTYSSGSPTKRQSQLVDTLQQRV 1358
Cdd:pfam07902  290 LQDAEKNYSS--------------LTQTVKGLqSTVSDPNSKLESRITQLAGLIEQKV 333
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 494-1218 2.13e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 42.85  E-value: 2.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  494 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLT------NEAATGSHRII---EELREQLKDLKGKYEGASAE 564
Cdd:pfam01576   11 EEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQaetelcAEAEEMRARLAarkQELEEILHELESRLEEEEER 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  565 VGKLRSQIKQSEMLVGEFkrdEGRLVEEN---KRLQKECGTCEVELERRGRRVVELEGQLKELGAKLALSvpTEKFESMK 641
Cdd:pfam01576   91 SQQLQNEKKKMQQHIQDL---EEQLDEEEaarQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKERKLL--EERISEFT 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  642 SSLSNDiNEKVKRLAEVGRDYESAQGEIRQLKRDLESVRaqhirpEEHEQLRSRLEQKSGELGKKVSELT-----LKNQT 716
Cdd:pfam01576  166 SNLAEE-EEKAKSLSKLKNKHEAMISDLEERLKKEEKGR------QELEKAKRKLEGESTDLQEQIAELQaqiaeLRAQL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  717 LQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMkkshdvnvEDLNKKLSEATQRYTEKKQEAERLLAENDKLTK 796
Cdd:pfam01576  239 AKKEEELQAALARLEEETAQKNNALKKIRELEAQISELQ--------EDLESERAARNKAEKQRRDLGEELEALKTELED 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  797 NVSRLEAVFVAPEKHEKELMGLKSNIAELKK----QLSELNKKCGEGQEKI------------------RALMSENSSLK 854
Cdd:pfam01576  311 TLDTTAAQQELRSKREQEVTELKKALEEETRsheaQLQEMRQKHTQALEELteqleqakrnkanlekakQALESENAELQ 390

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  855 KTLssqyvpaKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRM 934
Cdd:pfam01576  391 AEL-------RTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDV 463

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  935 STVSQSLKEAQEanaailadhrQGQEEI---VSLHAEIKAQKKELDTIQEciklkyaplaRLEECERKFKATEK---GLK 1008
Cdd:pfam01576  464 SSLESQLQDTQE----------LLQEETrqkLNLSTRLRQLEDERNSLQE----------QLEEEEEAKRNVERqlsTLQ 523

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1009 EQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSER 1088
Cdd:pfam01576  524 AQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQ 603

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1089 EK----LVEEKAkqaseiLAAQNLLQKQPVPLEQVEALKKSLNGTIEqLKEELRSKQRCLEREQQTVSQLQQLLENQKNS 1164
Cdd:pfam01576  604 KKfdqmLAEEKA------ISARYAEERDRAEAEAREKETRALSLARA-LEEALEAKEELERTNKQLRAEMEDLVSSKDDV 676

                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1270530344 1165 SVTLAEHLKLKEALEKEVGIMKASLREKEEESQkkTKEVSKLQTEVqtTKQALK 1218
Cdd:pfam01576  677 GKNVHELERSKRALEQQVEEMKTQLEELEDELQ--ATEDAKLRLEV--NMQALK 726
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 988-1334 2.19e-03

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 42.32  E-value: 2.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  988 APLARLEECERKfkATEKGLKEQLSEQTHKCRQRDeevKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKA 1067
Cdd:pfam05667  214 AELAAAQEWEEE--WNSQGLASRLTPEEYRKRKRT---KLLKRIAEQLRSAALAGTEATSGASRSAQDLAELLSSFSGSS 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1068 DELSKQLK----DLSQKYSDVKSEREKLVEEKAKQASEilaaQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELrskqrc 1143
Cdd:pfam05667  289 TTDTGLTKgsrfTHTEKLQFTNEAPAATSSPPTKVETE----EELQQQREEELEELQEQLEDLESSIQELEKEI------ 358

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1144 lEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEvgimkasLREKEEEsqkktkeVSKLQTEVQTTKQALKNL--- 1220
Cdd:pfam05667  359 -KKLESSIKQVEEELEELKEQNEELEKQYKVKKKTLDL-------LPDAEEN-------IAKLQALVDASAQRLVELagq 423

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1221 -ETREVVDMSKY---KATKNDLETQISNLNDKLASLNRKYdQACEEKVSAKDE--KELLhlsieqeirDQKERCDKSlTT 1294
Cdd:pfam05667  424 wEKHRVPLIEEYralKEAKSNKEDESQRKLEEIKELREKI-KEVAEEAKQKEElyKQLV---------AEYERLPKD-VS 492

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 1270530344 1295 IMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLS 1334
Cdd:pfam05667  493 RSAYTRRILEIVKNIKKQKEEITKILSDTKSLQKEINSLT 532
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 445-1225 2.24e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 42.47  E-value: 2.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  445 EILKKELETLRTYYDSAKQDRLKFQNELAHKVAECKALAleceRVKEDSDEQIKQLEDALKDVQKRMYESEgKVKQMQTH 524
Cdd:pfam01576  359 EELTEQLEQAKRNKANLEKAKQALESENAELQAELRTLQ----QAKQDSEHKRKKLEGQLQELQARLSESE-RQRAELAE 433

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  525 FLAlkeHLTNEaatgshriIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCE 604
Cdd:pfam01576  434 KLS---KLQSE--------LESVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQ 502

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  605 VELERRGRRVVELEGQLKELGAKLAlsvptekfesmksslsndinEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHi 684
Cdd:pfam01576  503 EQLEEEEEAKRNVERQLSTLQAQLS--------------------DMKKKLEEDAGTLEALEEGKKRLQRELEALTQQL- 561

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  685 rpEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQqvhsLTVEMKTryVPLRVSEEMKKSHDVNVE 764
Cdd:pfam01576  562 --EEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQ----MLAEEKA--ISARYAEERDRAEAEARE 633

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  765 DLNKKLS--EATQRYTEKKQEAER----LLAENDKLtknVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGE 838
Cdd:pfam01576  634 KETRALSlaRALEEALEAKEELERtnkqLRAEMEDL---VSSKDDVGKNVHELERSKRALEQQVEEMKTQLEELEDELQA 710

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  839 gqekiralmSENSSLKKTLSSQYVPAK----------THEEVKASLNSTV---------EKTNRAL-LEAKKRFDDTSQE 898
Cdd:pfam01576  711 ---------TEDAKLRLEVNMQALKAQferdlqardeQGEEKRRQLVKQVreleaeledERKQRAQaVAAKKKLELDLKE 781

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  899 -------VSKLRDEnevLRRNLENVQNQMKADYVSLEE-HSRRMSTVSQSlKEAQEANAAILADHRQGQEEIVSLHAEIK 970
Cdd:pfam01576  782 leaqidaANKGREE---AVKQLKKLQAQMKDLQRELEEaRASRDEILAQS-KESEKKLKNLEAELLQLQEDLAASERARR 857

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  971 AQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQdrn 1050
Cdd:pfam01576  858 QAQQERDELADEIASGASGKSALQDEKRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTSQ--- 934

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1051 alaeeareaerALSGKADELSKQLKDLSQKYsdvkSEREKLVEEKAKQASEILAAQnllqkqpvpLEQVEalkkslngti 1130
Cdd:pfam01576  935 -----------KSESARQQLERQNKELKAKL----QEMEGTVKSKFKSSIAALEAK---------IAQLE---------- 980

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1131 EQLKEELRSKQ---RCLEREQQTVSQLQQLLENQKNSSVTLAEHLklkEALEKEVGIMKASLREKEEESQKKTKEVSKLQ 1207
Cdd:pfam01576  981 EQLEQESRERQaanKLVRRTEKKLKEVLLQVEDERRHADQYKDQA---EKGNSRMKQLKRQLEEAEEEASRANAARRKLQ 1057

                          810
                   ....*....|....*...
gi 1270530344 1208 TEVQTTKQALKNLeTREV 1225
Cdd:pfam01576 1058 RELDDATESNESM-NREV 1074
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 969-1310 2.39e-03

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 42.13  E-value: 2.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  969 IKAqKKELDTIQEciklkyaplaRLEECERKFKATEKGLKEqLSEQTHKCRQRDEEVKKGKQEnerlradlaaLQKELQD 1048
Cdd:PRK04778   101 RKA-KHEINEIES----------LLDLIEEDIEQILEELQE-LLESEEKNREEVEQLKDLYRE----------LRKSLLA 158

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1049 RNALAeeareaeralsGKA-DELSKQLKDLsqkysdvKSEREKLVEEKAK----QASEILAAQ----NLLQKQpvpLEQV 1119
Cdd:PRK04778   159 NRFSF-----------GPAlDELEKQLENL-------EEEFSQFVELTESgdyvEAREILDQLeeelAALEQI---MEEI 217

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1120 EALKKSLNGTI-EQLkEELRSKQRCLERE------QQTVSQLQQLLENQKNSSVTLAEhLKLKEALEKEVGIMKA----- 1187
Cdd:PRK04778   218 PELLKELQTELpDQL-QELKAGYRELVEEgyhldhLDIEKEIQDLKEQIDENLALLEE-LDLDEAEEKNEEIQERidqly 295

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1188 SLREKEEESQKK-TKEVSKLQTEVQTTKQALKNL--ETREVvdMSKYKATKNDLETQiSNLNDKLASLNRKYDQACEEKv 1264
Cdd:PRK04778   296 DILEREVKARKYvEKNSDTLPDFLEHAKEQNKELkeEIDRV--KQSYTLNESELESV-RQLEKQLESLEKQYDEITERI- 371

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 1270530344 1265 sakDEKELLHlsieQEIRDQKERCDKSLTTIMELQQRIQESAKQIE 1310
Cdd:PRK04778   372 ---AEQEIAY----SELQEELEEILKQLEEIEKEQEKLSEMLQGLR 410
PRK11281 PRK11281
mechanosensitive channel MscK;
1066-1409 2.55e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 42.59  E-value: 2.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1066 KADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNL--LQKQpvpLEQVEALKKSLNGTIEQLKEELRSKQRC 1143
Cdd:PRK11281    81 ETEQLKQQLAQAPAKLRQAQAELEALKDDNDEETRETLSTLSLrqLESR---LAQTLDQLQNAQNDLAEYNSQLVSLQTQ 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1144 LEREQQTVS----QLQQ---LLENQKNSSVTLAEHLKLKEALEkevgimKASLREKEEESQKKTKEVSKLQtEVQTTKQA 1216
Cdd:PRK11281   158 PERAQAALYansqRLQQirnLLKGGKVGGKALRPSQRVLLQAE------QALLNAQNDLQRKSLEGNTQLQ-DLLQKQRD 230

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1217 LKNLETrevvdmskykatkNDLETQISNLNDklaSLNRKYDQACEEKVSakdekellhlsiEQEIRDQKERCDKSLTTIM 1296
Cdd:PRK11281   231 YLTARI-------------QRLEHQLQLLQE---AINSKRLTLSEKTVQ------------EAQSQDEAARIQANPLVAQ 282

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1297 ELQQRIQESAKQIEAKDnKITELLNDVERLKQALNGLSQltysSGSPTKRQ-SQLVDTL-------QQR--------VRD 1360
Cdd:PRK11281   283 ELEINLQLSQRLLKATE-KLNTLTQQNLRVKNWLDRLTQ----SERNIKEQiSVLKGSLllsrilyQQQqalpsadlIEG 357

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1270530344 1361 LQQQLADAdRQHQ-EV---------IAIYRTHLLSAAQGHMDEDVQAALLQIIQMRQGL 1409
Cdd:PRK11281   358 LADRIADL-RLEQfEInqqrdalfqPDAYIDKLEAGHKSEVTDEVRDALLQLLDERREL 415
PHA02946 PHA02946
ankyin-like protein; Provisional
 152-228 2.58e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 41.96  E-value: 2.58e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1270530344  152 IQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTAL--MLGCEYGCRDAVEVLVKNGADL 228
Cdd:PHA02946    55 VEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLyyLSGTDDEVIERINLLVQYGAKI 133
CagA_N pfam18971
CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial ...
 1030-1308 2.72e-03

CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial virulence determinant and critical for gastric carcinogenesis. X-ray crystallographic analysis of the N-terminal CagA fragment (residues 1-876) revealed that the region has a structure comprised of three discrete domains. Domain I constitutes a mobile CagA N terminus, while Domain II tethers CagA to the plasma membrane by interacting with membrane phosphatidylserine. Domain III interacts intramolecularly with the intrinsically disordered C-terminal region, and this interaction potentiates the pathogenic scaffold/hub function of CagA.


Pssm-ID: 408741 [Multi-domain]  Cd Length: 876  Bit Score: 42.45  E-value: 2.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1030 QENERLRADLAALQKELQDRnALAEEAREAERALSGKADELSKQLKDLSQ---KYSDVKSEREKLVEEKA--KQASEILA 1104
Cdd:pfam18971  573 QEANKLIKDFLSSNKELAGK-ALNFNKAVAEAKSTGNYDEVKKAQKDLEKslrKREHLEKEVEKKLESKSgnKNKMEAKA 651

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1105 AQNLLQKQPVPLEQVEALKKS----LNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEH-LKLKEALE 1179
Cdd:pfam18971  652 QANSQKDEIFALINKEANRDAraiaYTQNLKGIKRELSDKLEKISKDLKDFSKSFDEFKNGKNKDFSKAEEtLKALKGSV 731

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1180 KEVGImkaslrekeeesqkKTKEVSKlqteVQTTKQALKNLETREVVDMSKYKATKNDLETQISN------LNDKLASLN 1253
Cdd:pfam18971  732 KDLGI--------------NPEWISK----VENLNAALNEFKNGKNKDFSKVTQAKSDLENSVKDviinqkVTDKVDNLN 793

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1270530344 1254 RKYDQACEEKVSAKDEK---ELLHLSIEQEIRDQKERCDKSLTTIMELQQRIQESAKQ 1308
Cdd:pfam18971  794 QAVSVAKAMGDFSRVEQvlaDLKNFSKEQLAQQAQKNEDFNTGKNSELYQSVKNSVNK 851
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
 952-1215 2.76e-03

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 41.98  E-value: 2.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  952 LADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERK------FKATEKGLKEQLSEQTHKCRQRDEEV 1025
Cdd:pfam05622   96 VLELQHRNEELTSLAEEAQALKDEMDILRESSDKVKKLEATVETYKKKledlgdLRRQVKLLEERNAEYMQRTLQLEEEL 175

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1026 KKGKQenerLRADLAALQKELQDrnalaeeAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAK-------- 1097
Cdd:pfam05622  176 KKANA----LRGQLETYKRQVQE-------LHGKLSEESKKADKLEFEYKKLEEKLEALQKEKERLIIERDTlretneel 244

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1098 -----QASEILAAQNLLQKQPVPLEQV--EALKKSLNGTIEQLKEE---LRSKQRCLEREQQTVsqLQQLLENQKNSSVT 1167
Cdd:pfam05622  245 rcaqlQQAELSQADALLSPSSDPGDNLaaEIMPAEIREKLIRLQHEnkmLRLGQEGSYRERLTE--LQQLLEDANRRKNE 322

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1270530344 1168 LAEHLKLKE----------------------------ALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQ 1215
Cdd:pfam05622  323 LETQNRLANqrilelqqqveelqkalqeqgskaedssLLKQKLEEHLEKLHEAQSELQKKKEQIEELEPKQDSNLA 398
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1117-1335 2.89e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 41.93  E-value: 2.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1117 EQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQllenqKNSSVTLAEHLKLkeaLEKEVGIMKASLREKEEES 1196
Cdd:COG3206    164 QNLELRREEARKALEFLEEQLPELRKELEEAEAALEEFRQ-----KNGLVDLSEEAKL---LLQQLSELESQLAEARAEL 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1197 QKKTKEVSKLQTEVQTTKQALKNLETREVVdmSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLS 1276
Cdd:COG3206    236 AEAEARLAALRAQLGSGPDALPELLQSPVI--QQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQLQQEAQR 313

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1270530344 1277 IEQEIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQ 1335
Cdd:COG3206    314 ILASLEAELEALQAREASLQAQLAQLEARLAELPELEAELRRLEREVEVARELYESLLQ 372
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 168-196 3.39e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.47  E-value: 3.39e-03
                           10        20
                   ....*....|....*....|....*....
gi 1270530344  168 DGRTPLVLATQMCRPTICQLLIDRGADVN 196
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
Ank_5 pfam13857
Ankyrin repeats (many copies);
157-206 3.62e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.94  E-value: 3.62e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1270530344  157 DHG-ASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTAL 206
Cdd:pfam13857    3 EHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 1091-1319 3.65e-03

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 41.73  E-value: 3.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1091 LVEEKAKQASEILAAQNLLQkqpVPLEQVEALKKSlngtIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAE 1170
Cdd:pfam10174  371 LTEEKSTLAGEIRDLKDMLD---VKERKINVLQKK----IENLQEQLRDKDKQLAGLKERVKSLQTDSSNTDTALTTLEE 443

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1171 HLKLK----EALEKEVGIMKASLREKEEESQKKTKE----VSKLQTEVQTTKQAL-------KNLETREVVDMSKYKATK 1235
Cdd:pfam10174  444 ALSEKeriiERLKEQREREDRERLEELESLKKENKDlkekVSALQPELTEKESSLidlkehaSSLASSGLKKDSKLKSLE 523

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1236 NDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLsiEQEIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNK 1315
Cdd:pfam10174  524 IAVEQKKEECSKLENQLKKAHNAEEAVRTNPEINDRIRLL--EQEVARYKEESGKAQAEVERLLGILREVENEKNDKDKK 601


                   ....
gi 1270530344 1316 ITEL 1319
Cdd:pfam10174  602 IAEL 605
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1116-1404 3.73e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 41.98  E-value: 3.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1116 LEQVEALKKSLnGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTlaEHLKLKEALEKEVGIMKASLREKEEE 1195
Cdd:TIGR02169  176 LEELEEVEENI-ERLDLIIDEKRQQLERLRREREKAERYQALLKEKREYEGY--ELLKEKEALERQKEAIERQLASLEEE 252

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1196 SQKKTKEVSKLQTEVQTTKQALKNLETReVVDMSKYKAtkNDLETQISNLNDKLASLNRKYDQAceekvsakdekellhl 1275
Cdd:TIGR02169  253 LEKLTEEISELEKRLEEIEQLLEELNKK-IKDLGEEEQ--LRVKEKIGELEAEIASLERSIAEK---------------- 313

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1276 siEQEIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQltyssgsPTKRQSQLVDTLQ 1355
Cdd:TIGR02169  314 --ERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRA-------ELEEVDKEFAETR 384

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1356 QRVRDLQQQLADADRQHQEVIAIYRTHLLSAAQGHMD-EDVQAALLQIIQ 1404
Cdd:TIGR02169  385 DELKDYREKLEKLKREINELKRELDRLQEELQRLSEElADLNAAIAGIEA 434
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 19-177 4.05e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.42  E-value: 4.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   19 PSSPTAVASTQSaEWNKYDDRL--MKAAERGDVEKVSSILAKKGVHPGKLDVEGRSAFHVVASkGNLECLNAILTHGIDV 96
Cdd:PTZ00322    31 PISFERMAAIQE-EIARIDTHLeaLEATENKDATPDHNLTTEEVIDPVVAHMLTVELCQLAAS-GDAVGARILLTGGADP 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344   97 ATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLL-----CDHGASVNAK--DIDG 169
Cdd:PTZ00322   109 NCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLsrhsqCHFELGANAKpdSFTG 188


                   ....*...
gi 1270530344  170 RTPLVLAT 177
Cdd:PTZ00322   189 KPPSLEDS 196
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 1096-1357 4.69e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 41.58  E-value: 4.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1096 AKQASEILAAQNLLQ----KQPVPLEQVEALKKSLNGTIEQLKEELRSK--QRCLEREQQTVSQLQQLLENQKNSSVTLA 1169
Cdd:PRK10929    20 ATAPDEKQITQELEQakaaKTPAQAEIVEALQSALNWLEERKGSLERAKqyQQVIDNFPKLSAELRQQLNNERDEPRSVP 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1170 EHLKLKEaLEKEVGIMKASLREKEEESQK---KTKEVS-------KLQTEvqtTKQALKNLETREvvdMSKYKATKNDLE 1239
Cdd:PRK10929   100 PNMSTDA-LEQEILQVSSQLLEKSRQAQQeqdRAREISdslsqlpQQQTE---ARRQLNEIERRL---QTLGTPNTPLAQ 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1240 TQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQeIRDQKERCDKSL----TTIMELQQRIQESA--------K 1307
Cdd:PRK10929   173 AQLTALQAESAALKALVDELELAQLSANNRQELARLRSEL-AKKRSQQLDAYLqalrNQLNSQRQREAERAlestellaE 251

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1270530344 1308 QIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSptkRQSQLV-DTLQQR 1357
Cdd:PRK10929   252 QSGDLPKSIVAQFKINRELSQALNQQAQRMDLIAS---QQRQAAsQTLQVR 299
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
542-734 4.74e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 41.54  E-value: 4.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  542 RIIEELREQLKDLKGKYEGASAEVGKLRSQiKQSEMLVGEFKRDEGRLVEENKRLQkecgtcEVELERRgrrvvELEGQL 621
Cdd:COG3206    175 KALEFLEEQLPELRKELEEAEAALEEFRQK-NGLVDLSEEAKLLLQQLSELESQLA------EARAELA-----EAEARL 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  622 KELGAKLALS---VPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQhirpeeheqLRSRLEQ 698
Cdd:COG3206    243 AALRAQLGSGpdaLPELLQSPVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQ---------LQQEAQR 313

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1270530344  699 KSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQ 734
Cdd:COG3206    314 ILASLEAELEALQAREASLQAQLAQLEARLAELPEL 349
Ank_4 pfam13637
Ankyrin repeats (many copies);
169-222 5.53e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.48  E-value: 5.53e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1270530344  169 GRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLV 222
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
944-1150 5.56e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 41.44  E-value: 5.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  944 AQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQEciklkyaplaRLEECERkfkatekgLKEQLSEQThKCRQRDE 1023
Cdd:COG4913    608 NRAKLAALEAELAELEEELAEAEERLEALEAELDALQE----------RREALQR--------LAEYSWDEI-DVASAER 668

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1024 EVKKGKQENERLRA---DLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQAS 1100
Cdd:COG4913    669 EIAELEAELERLDAssdDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELR 748

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1101 EILAAQNLLQKQPvplEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQT 1150
Cdd:COG4913    749 ALLEERFAAALGD---AVERELRENLEERIDALRARLNRAEEELERAMRA 795
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1096-1315 5.82e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.90  E-value: 5.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1096 AKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQ-QLLENQKNSSVTLAEHLKL 1174
Cdd:COG4942     16 AAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEqELAALEAELAELEKEIAEL 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1175 KEALEKEVGIMKASLREKEEESQKKTKEV---SKLQTEVQTTKQALKNLETREVVDMSKYKATKNDLETQISNLNDKLAS 1251
Cdd:COG4942     96 RAELEAQKEELAELLRALYRLGRQPPLALllsPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAE 175

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1270530344 1252 LNRKYDQACEEKV---SAKDEKELLHLSIEQEIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNK 1315
Cdd:COG4942    176 LEALLAELEEERAaleALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAER 242
PLN02939 PLN02939
transferase, transferring glycosyl groups
 540-926 5.96e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 41.04  E-value: 5.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  540 SHRIIEEL----REQLKDLKGKYEGASAEVGKLRSQIKQSE---MLVGEFK----RDEGRLVEENKRLQKECGTCEVELE 608
Cdd:PLN02939   101 SMQRDEAIaaidNEQQTNSKDGEQLSDFQLEDLVGMIQNAEkniLLLNQARlqalEDLEKILTEKEALQGKINILEMRLS 180

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  609 RRGRRVVeLEGQlkelgAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPEE 688
Cdd:PLN02939   181 ETDARIK-LAAQ-----EKIHVEILEEQLEKLRNELLIRGATEGLCVHSLSKELDVLKEENMLLKDDIQFLKAELIEVAE 254

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  689 HEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLhadnkllnqqvhsltvemktryVPLRVSEEMKKshdvnVEDLNK 768
Cdd:PLN02939   255 TEERVFKLEKERSLLDASLRELESKFIVAQEDVSKL----------------------SPLQYDCWWEK-----VENLQD 307

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  769 KLSEATQRytekKQEAERLLAENDKLTKNVSRLEAVFVApekhekelmglkSNIAELKKQLSELNkkcgegQEKIRALMS 848
Cdd:PLN02939   308 LLDRATNQ----VEKAALVLDQNQDLRDKVDKLEASLKE------------ANVSKFSSYKVELL------QQKLKLLEE 365

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1270530344  849 EnsslkktlsSQYVPAKTHEEVKASLNSTVEktnralleakkrFDDTsqeVSKLRDENEvlRRNLENVQNQMKADYVS 926
Cdd:PLN02939   366 R---------LQASDHEIHSYIQLYQESIKE------------FQDT---LSKLKEESK--KRSLEHPADDMPSEFWS 417
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 769-981 6.64e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 40.58  E-value: 6.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  769 KLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAvfvapekhekELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMS 848
Cdd:COG3883     17 QIQAKQKELSELQAELEAAQAELDALQAELEELNE----------EYNELQAELEALQAEIDKLQAEIAEAEAEIEERRE 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  849 EnssLKKTLSSQYVPAKTHEEVKASLNST--VEKTNRALLEAK--KRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADY 924
Cdd:COG3883     87 E---LGERARALYRSGGSVSYLDVLLGSEsfSDFLDRLSALSKiaDADADLLEELKADKAELEAKKAELEAKLAELEALK 163

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1270530344  925 VSLEEhsrRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQE 981
Cdd:COG3883    164 AELEA---AKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAA 217
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 293-618 7.15e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.82  E-value: 7.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  293 REQREPHSFQDLEIENEDLREKLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIE 372
Cdd:TIGR02169  675 ELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIE 754

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  373 ALKNRFKYFESDHPgpgsypsnRKEDMLHKqgqmyttepqcaspgipphmhsrsmlrpLELSLPSqtsySENEILKKELE 452
Cdd:TIGR02169  755 NVKSELKELEARIE--------ELEEDLHK----------------------------LEEALND----LEARLSHSRIP 794

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  453 TLRTYYDSAKQDRLKFQNELAHKVAECKALALE---CERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQthflalk 529
Cdd:TIGR02169  795 EIQAELSKLEEEVSRIEARLREIEQKLNRLTLEkeyLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELE------- 867

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  530 ehltneaatgshRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELER 609
Cdd:TIGR02169  868 ------------EELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSE 935


                   ....*....
gi 1270530344  610 RGRRVVELE 618
Cdd:TIGR02169  936 IEDPKGEDE 944
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 1089-1211 8.88e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 40.58  E-value: 8.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1089 EKLVEEKAKQASEILAAQNLLQkqpvpleQVEALKKSLNGTIEQLKEELRSKQRCLERE-QQTVSQ--------LQQLLE 1159
Cdd:PRK00409   523 ASLEELERELEQKAEEAEALLK-------EAEKLKEELEEKKEKLQEEEDKLLEEAEKEaQQAIKEakkeadeiIKELRQ 595

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1270530344 1160 NQKNSSVTLAEHlKLKEALEKevgimkasLREKEEESQKKTKEVSKLQTEVQ 1211
Cdd:PRK00409   596 LQKGGYASVKAH-ELIEARKR--------LNKANEKKEKKKKKQKEKQEELK 638
COG5022 COG5022
Myosin heavy chain [General function prediction only];
1101-1364 9.59e-03

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 40.45  E-value: 9.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1101 EILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKnssvTLAEHLKLKEALEK 1180
Cdd:COG5022    763 RYLQALKRIKKIQVIQHGFRLRRLVDYELKWRLFIKLQPLLSLLGSRKEYRSYLACIIKLQK----TIKREKKLRETEEV 838

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1181 EVGIMKASLREKEEESQKKTKEVSKLQTEV--QTTKQALKNLETR------EVVDMSKYKATKNDLETQISNLND----- 1247
Cdd:COG5022    839 EFSLKAEVLIQKFGRSLKAKKRFSLLKKETiyLQSAQRVELAERQlqelkiDVKSISSLKLVNLELESEIIELKKslssd 918

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1248 -------------KLASLNRKYD-------QACEEKVSAKD------------EKELLHLSIEQEIRDQKERCDKS---- 1291
Cdd:COG5022    919 lienlefkteliaRLKKLLNNIDleegpsiEYVKLPELNKLhevesklketseEYEDLLKKSTILVREGNKANSELknfk 998

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1270530344 1292 --LTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYSSGsPTKRQSQLVDTLQQRVRDLQQQ 1364
Cdd:COG5022    999 keLAELSKQYGALQESTKQLKELPVEVAELQSASKIISSESTELSILKPLQK-LKGLLLLENNQLQARYKALKLR 1072
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 939-1407 9.81e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 40.34  E-value: 9.81e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344  939 QSLKEAQEANAAILADhRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERK--------FKATEKGLKEQ 1010
Cdd:TIGR00618  156 QFLKAKSKEKKELLMN-LFPLDQYTQLALMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDtyherkqvLEKELKHLREA 234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1011 LSE--QTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRnALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSER 1088
Cdd:TIGR00618  235 LQQtqQSHAYLTQKREAQEEQLKKQQLLKQLRARIEELRAQ-EAVLEETQERINRARKAAPLAAHIKAVTQIEQQAQRIH 313

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1089 EKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQT-----VSQLQQLLENQKN 1163
Cdd:TIGR00618  314 TELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHtltqhIHTLQQQKTTLTQ 393

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1164 SSVTLAEHLKLKEALEKEVGIMKASLR---------EKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVvdMSKYKAt 1234
Cdd:TIGR00618  394 KLQSLCKELDILQREQATIDTRTSAFRdlqgqlahaKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQES--AQSLKE- 470

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1235 KNDLETQISNLNDKLASLNRKYDQACEEKVSAKD--EKELLHLSIEQEIRDQKE----RCDKSLTTIMELQQRIQESAKQ 1308
Cdd:TIGR00618  471 REQQLQTKEQIHLQETRKKAVVLARLLELQEEPCplCGSCIHPNPARQDIDNPGpltrRMQRGEQTYAQLETSEEDVYHQ 550

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530344 1309 IEAKDNKITELLNDVERLKQALNGLSQLTYSSgsptkrqSQLVDTLQQRVRDLQQQLADADRQHQEVIAIYRTHLLSAAQ 1388
Cdd:TIGR00618  551 LTSERKQRASLKEQMQEIQQSFSILTQCDNRS-------KEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQP 623

                          490
                   ....*....|....*....
gi 1270530344 1389 GHMDEDVQAALLQIIQMRQ 1407
Cdd:TIGR00618  624 EQDLQDVRLHLQQCSQELA 642
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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