NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1270530357|ref|NP_001344331|]
View 

SUN domain-containing ossification factor isoform 3 precursor [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Sad1_UNC pfam07738
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ...
 322-451 6.90e-46

Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.


:

Pssm-ID: 400199  Cd Length: 130  Bit Score: 161.30  E-value: 6.90e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530357  322 NPEAKSTSAILIENmdlYMLNPC----STKIWFVIELCEPIQVKQFDIANYE--LFSSTPKDFLVSISDRYPTNKWIKLG 395
Cdd:pfam07738    2 NYEAKPPKVILQPD---YMPGPCwsfkGSRGFVVIELSEFIIVEAITLEHVEksVFSSAPKDFEVSGSDRYPTTKWVLLG 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1270530357  396 TFH-GRDERNVQSFPLDEQMYAkyvkmFIKYIKVELLSHFGSEHFCPLSLIRVFGTS 451
Cdd:pfam07738   79 EFSyDLDGKTIQTFQLENPPDI-----WVKYVKLRILSNYGNEHYTCLYRFRVHGTV 130
MbeD_MobD super family cl46873
MbeD/MobD like; The MbeD and MobD proteins are plasmid encoded, and are involved in the ...
 932-1001 3.03e-03

MbeD/MobD like; The MbeD and MobD proteins are plasmid encoded, and are involved in the plasmids mobilization and transfer in the presence of conjugative plasmids.


The actual alignment was detected with superfamily member pfam04899:

Pssm-ID: 481213  Cd Length: 70  Bit Score: 37.54  E-value: 3.03e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530357  932 LEELSQRYRKQMEEMQKAFnktiVKLQNTSriaeEQDQRQTEAihlLQAQLTNMTQLVSNLSATVAELKR 1001
Cdd:pfam04899   12 LEQLQQDYEQRLQEWESAF----AELQRMF----GLTQRENAA---LSEQVTGLSQQVQSLSEQVRRLSR 70
 
Name Accession Description Interval E-value
Sad1_UNC pfam07738
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ...
 322-451 6.90e-46

Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.


Pssm-ID: 400199  Cd Length: 130  Bit Score: 161.30  E-value: 6.90e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530357  322 NPEAKSTSAILIENmdlYMLNPC----STKIWFVIELCEPIQVKQFDIANYE--LFSSTPKDFLVSISDRYPTNKWIKLG 395
Cdd:pfam07738    2 NYEAKPPKVILQPD---YMPGPCwsfkGSRGFVVIELSEFIIVEAITLEHVEksVFSSAPKDFEVSGSDRYPTTKWVLLG 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1270530357  396 TFH-GRDERNVQSFPLDEQMYAkyvkmFIKYIKVELLSHFGSEHFCPLSLIRVFGTS 451
Cdd:pfam07738   79 EFSyDLDGKTIQTFQLENPPDI-----WVKYVKLRILSNYGNEHYTCLYRFRVHGTV 130
MbeD_MobD pfam04899
MbeD/MobD like; The MbeD and MobD proteins are plasmid encoded, and are involved in the ...
 932-1001 3.03e-03

MbeD/MobD like; The MbeD and MobD proteins are plasmid encoded, and are involved in the plasmids mobilization and transfer in the presence of conjugative plasmids.


Pssm-ID: 113664  Cd Length: 70  Bit Score: 37.54  E-value: 3.03e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530357  932 LEELSQRYRKQMEEMQKAFnktiVKLQNTSriaeEQDQRQTEAihlLQAQLTNMTQLVSNLSATVAELKR 1001
Cdd:pfam04899   12 LEQLQQDYEQRLQEWESAF----AELQRMF----GLTQRENAA---LSEQVTGLSQQVQSLSEQVRRLSR 70
 
Name Accession Description Interval E-value
Sad1_UNC pfam07738
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ...
 322-451 6.90e-46

Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.


Pssm-ID: 400199  Cd Length: 130  Bit Score: 161.30  E-value: 6.90e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530357  322 NPEAKSTSAILIENmdlYMLNPC----STKIWFVIELCEPIQVKQFDIANYE--LFSSTPKDFLVSISDRYPTNKWIKLG 395
Cdd:pfam07738    2 NYEAKPPKVILQPD---YMPGPCwsfkGSRGFVVIELSEFIIVEAITLEHVEksVFSSAPKDFEVSGSDRYPTTKWVLLG 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1270530357  396 TFH-GRDERNVQSFPLDEQMYAkyvkmFIKYIKVELLSHFGSEHFCPLSLIRVFGTS 451
Cdd:pfam07738   79 EFSyDLDGKTIQTFQLENPPDI-----WVKYVKLRILSNYGNEHYTCLYRFRVHGTV 130
MbeD_MobD pfam04899
MbeD/MobD like; The MbeD and MobD proteins are plasmid encoded, and are involved in the ...
 932-1001 3.03e-03

MbeD/MobD like; The MbeD and MobD proteins are plasmid encoded, and are involved in the plasmids mobilization and transfer in the presence of conjugative plasmids.


Pssm-ID: 113664  Cd Length: 70  Bit Score: 37.54  E-value: 3.03e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270530357  932 LEELSQRYRKQMEEMQKAFnktiVKLQNTSriaeEQDQRQTEAihlLQAQLTNMTQLVSNLSATVAELKR 1001
Cdd:pfam04899   12 LEQLQQDYEQRLQEWESAF----AELQRMF----GLTQRENAA---LSEQVTGLSQQVQSLSEQVRRLSR 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH