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Conserved domains on  [gi|1249618446|ref|NP_001343338|]
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solute carrier family 2, facilitated glucose transporter member 8 isoform 2 precursor [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 27-290 1.96e-135

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17433:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 416  Bit Score: 390.78  E-value: 1.96e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  27 FLASFAAALGPLSFGFALGYSSPAIPSLRRTAPPALRLGDNAASWFGAVVTLGAAAGGILGGWLLDRAGRKLSLLLCTVP 106
Cdd:cd17433     1 FLATFAAVLGPLSFGFVLGYSSPAIPSLQRIADPALRLDDAAASWFGSVVTLGAAAGGVLGGWIVDRAGRKLSLMLCSVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 107 FVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILLAYVAGWVLEWRWLAV 186
Cdd:cd17433    81 FIAGFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRVRGTLGSCVQLMVVIGIMGAYLAGLVLDWRWLAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 187 LGCVPPTLMLLLMCYMPETPRFLLTQHQYQEAMAALRFLWGSEEGWEEPPVGAE------HQGFQLALLRRPGIYKPLII 260
Cdd:cd17433   161 LGSIPPTLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLRGPDQGWEWECIGIEqsfhleEQSFSLALLKQPGIYKPLII 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1249618446 261 GISLMVFQQLSGVNAIMFYANSIFEEAKFK 290
Cdd:cd17433   241 GVSLMAFQQLTGINAVMFYAETIFEEAKFK 270
 
Name Accession Description Interval E-value
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 27-290 1.96e-135

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 390.78  E-value: 1.96e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  27 FLASFAAALGPLSFGFALGYSSPAIPSLRRTAPPALRLGDNAASWFGAVVTLGAAAGGILGGWLLDRAGRKLSLLLCTVP 106
Cdd:cd17433     1 FLATFAAVLGPLSFGFVLGYSSPAIPSLQRIADPALRLDDAAASWFGSVVTLGAAAGGVLGGWIVDRAGRKLSLMLCSVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 107 FVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILLAYVAGWVLEWRWLAV 186
Cdd:cd17433    81 FIAGFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRVRGTLGSCVQLMVVIGIMGAYLAGLVLDWRWLAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 187 LGCVPPTLMLLLMCYMPETPRFLLTQHQYQEAMAALRFLWGSEEGWEEPPVGAE------HQGFQLALLRRPGIYKPLII 260
Cdd:cd17433   161 LGSIPPTLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLRGPDQGWEWECIGIEqsfhleEQSFSLALLKQPGIYKPLII 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1249618446 261 GISLMVFQQLSGVNAIMFYANSIFEEAKFK 290
Cdd:cd17433   241 GVSLMAFQQLTGINAVMFYAETIFEEAKFK 270
Sugar_tr pfam00083
Sugar (and other) transporter;
29-290 4.02e-39

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 143.57  E-value: 4.02e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  29 ASFAAALGPLSFGFALGYSSPAIPSL----RRTAPPALRLGDNAASWFGAVVTLGAAAGGI---LGGWLLDRAGRKLSLL 101
Cdd:pfam00083   1 VALVAALGGFLFGYDTGVIGAFLTLIdffkNFGLSKSVSSLAALSVLSGLIVSIFSVGCFIgslFAGKLGDRFGRKKSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 102 LCTVPFVTGFAVITAARD---VWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILLAYVAGWV 178
Cdd:pfam00083  81 IANVLFVIGAVLQGAAKGkwsVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 179 L-------EWRWLAVLGCVPPTLMLLLMCYMPETPRFLLTQHQYQEAMAALRFLWGSE-------EGWEEPPVGAEHQ-G 243
Cdd:pfam00083 161 LnktsnsdGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRGVPdvdreldEIKDSLEAGQEAEkA 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1249618446 244 FQLALLRRPGIYKPLIIGISLMVFQQLSGVNAIMFYANSIFEEAKFK 290
Cdd:pfam00083 241 SWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLS 287
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 25-290 1.20e-35

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 134.39  E-value: 1.20e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  25 RVFLASFAAALGPLSFGFALGYSSPAIPSLRRTAPPALRLGDNAASWFGAVVTLGAAAGGI----LGGWLLDRAGRKLSL 100
Cdd:TIGR00879  25 KVALLSLIAAIGGLMFGYDTGVIGGALALPAFEFKFTSANSDSYSSSLWGLVVSIFLVGGFigalFAGWLSDRFGRKKSL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 101 LLCTVPFVTGFAVITAAR---DVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILLAY---- 173
Cdd:TIGR00879 105 LIIALLFVIGAILMGLAAfalSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYgfgs 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 174 ---VAGWVLEWRWLAVLGCVPPTLMLLLMCYMPETPRFLLTQHQYQEAMAALRFLWGSEEgwEEPPVGAEHQGFQLALLR 250
Cdd:TIGR00879 185 gkvSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLARLRGTSG--EDKELLDELELIDIKRSI 262

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1249618446 251 R---------------PGIYKPLIIGISLMVFQQLSGVNAIMFYANSIFEEAKFK 290
Cdd:TIGR00879 263 EkrsvqpswgslfsstRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVS 317
xylE PRK10077
D-xylose transporter XylE; Provisional
 24-287 4.22e-26

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 107.86  E-value: 4.22e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  24 RRVFLASFAAALGPLSFGFALGYSSPAIPSLRRTAPPALRLG-DNAASWFGAVVTLGA---AAGGILGGWLLDRAGRKLS 99
Cdd:PRK10077    8 SYIFSITLVATLGGLLFGYDTAVISGTVESLNTVFVAPQNLSeSAANSLLGFCVASALigcIIGGALGGYCSNRFGRRDS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 100 LLLCTVPFVT----------GFAVITAARDVWMLLGGRLLTGLACGV--ASLVAPVYISEIAYPAVRGLLGSCVQLMVVT 167
Cdd:PRK10077   88 LKIAAVLFFIsalgsawpefGFTSIGPDNTGYVPEFVIYRIIGGIGVglASMLSPMYIAEIAPAHIRGKLVSFNQFAIIF 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 168 GILLAYVAGWVLE------------WRWLAVLGCVPPTLMLLLMCYMPETPRFLLTQHQYQEAMAALRFLWGSEEGweep 235
Cdd:PRK10077  168 GQLVVYFVNYFIArsgdaswlntdgWRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILRKIMGNTLA---- 243

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 236 pvGAEHQGFQLALLRRPGIYKPL--------IIGISLMVFQQLSGVNAIMFYANSIFEEA 287
Cdd:PRK10077  244 --TQALQEIKHSLDHGRKTGGKLlmfgvgviVIGVMLSVFQQFVGINVVLYYAPEIFKTL 301
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 17-210 9.66e-09

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 55.59  E-value: 9.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  17 EARTPRGRRVFLASFAAALGPLSFGFALGYSSPAIPSLRRtappALRLGDNAASWFGAVVTLGAAAGGILGGWLLDRAGR 96
Cdd:COG0477     3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAA----DLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  97 KLSLLLCTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILLAYVAG 176
Cdd:COG0477    79 KRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLG 158

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1249618446 177 WVLE----WRWLAVLGCVPPTLMLLLMCYMPETPRFLL 210
Cdd:COG0477   159 GLLVaalgWRWIFLINAPLGLLALVLRLRLPESRGLLL 196
 
Name Accession Description Interval E-value
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 27-290 1.96e-135

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 390.78  E-value: 1.96e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  27 FLASFAAALGPLSFGFALGYSSPAIPSLRRTAPPALRLGDNAASWFGAVVTLGAAAGGILGGWLLDRAGRKLSLLLCTVP 106
Cdd:cd17433     1 FLATFAAVLGPLSFGFVLGYSSPAIPSLQRIADPALRLDDAAASWFGSVVTLGAAAGGVLGGWIVDRAGRKLSLMLCSVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 107 FVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILLAYVAGWVLEWRWLAV 186
Cdd:cd17433    81 FIAGFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRVRGTLGSCVQLMVVIGIMGAYLAGLVLDWRWLAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 187 LGCVPPTLMLLLMCYMPETPRFLLTQHQYQEAMAALRFLWGSEEGWEEPPVGAE------HQGFQLALLRRPGIYKPLII 260
Cdd:cd17433   161 LGSIPPTLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLRGPDQGWEWECIGIEqsfhleEQSFSLALLKQPGIYKPLII 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1249618446 261 GISLMVFQQLSGVNAIMFYANSIFEEAKFK 290
Cdd:cd17433   241 GVSLMAFQQLTGINAVMFYAETIFEEAKFK 270
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 27-287 2.77e-85

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 263.67  E-value: 2.77e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  27 FLASFAAALGPLSFGFALGYSSPAIPSLRRTAPPALRLGDNAASWFGAVVTLGAAAGGILGGWLLDRAGRKLSLLLCTVP 106
Cdd:cd17358     1 LLATFVANLGSFSFGIAVGWSSPALPSLMSDNSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 107 FVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILLAYVAGWVLEWRWLAV 186
Cdd:cd17358    81 CILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLPWRTLAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 187 LGCVPPTLMLLLMCYMPETPRFLLTQHQYQEAMAALRFLWGSEEGWEEPP---------VGAEHQGFQLALLRRPGIYKP 257
Cdd:cd17358   161 IGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQFLRGKDADISKEAaeiqeelaeLEKEAKESSFSDLFQRKYLKP 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1249618446 258 LIIGISLMVFQQLSGVNAIMFYANSIFEEA 287
Cdd:cd17358   241 LVIGLGLMLFQQLSGINAVIFYASSIFDEA 270
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 27-288 1.12e-61

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 201.99  E-value: 1.12e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  27 FLASFAAALGPLSFGFALGYSSPAIPSLRRTAPPALRLGDNAASWFGAVVTLGAAAGGILGGWLLDRAGRKLSLLLCTVP 106
Cdd:cd17434     1 FLAVFSAVLGNFSFGYALVYTSPVIPALEQGDDPRLHLNVHQISWFGSVFTLGAAAGGLSAMFLNDRLGRKLSIMFSAVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 107 FVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILLAYVAGWVLEWRWLAV 186
Cdd:cd17434    81 SALGYLLMGSAQGIWMLLLGRFLTGFAGGITAASIPVYVSEISHPGVRGALGACPQIMAVFGSLALYALGLLLPWRWLAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 187 LGCVPPTLMLLLMCYMPETPRFLLTQHQYQEAMAALRFLWG--SEEGWE----EPPVGAEHQGFQLALLRRPGIYKPLII 260
Cdd:cd17434   161 AGEVPVVIMILLLCFMPNSPRFLISKGKDEKALKALAWLRGpnTDYMTEfeqiKDNIRKQSSRLSWAELKTPSYYKPILI 240

                         250       260
                  ....*....|....*....|....*...
gi 1249618446 261 GISLMVFQQLSGVNAIMFYANSIFEEAK 288
Cdd:cd17434   241 AVVMRFLQQLTGITPILVYLEPIFHLTA 268
Sugar_tr pfam00083
Sugar (and other) transporter;
29-290 4.02e-39

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 143.57  E-value: 4.02e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  29 ASFAAALGPLSFGFALGYSSPAIPSL----RRTAPPALRLGDNAASWFGAVVTLGAAAGGI---LGGWLLDRAGRKLSLL 101
Cdd:pfam00083   1 VALVAALGGFLFGYDTGVIGAFLTLIdffkNFGLSKSVSSLAALSVLSGLIVSIFSVGCFIgslFAGKLGDRFGRKKSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 102 LCTVPFVTGFAVITAARD---VWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILLAYVAGWV 178
Cdd:pfam00083  81 IANVLFVIGAVLQGAAKGkwsVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 179 L-------EWRWLAVLGCVPPTLMLLLMCYMPETPRFLLTQHQYQEAMAALRFLWGSE-------EGWEEPPVGAEHQ-G 243
Cdd:pfam00083 161 LnktsnsdGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRGVPdvdreldEIKDSLEAGQEAEkA 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1249618446 244 FQLALLRRPGIYKPLIIGISLMVFQQLSGVNAIMFYANSIFEEAKFK 290
Cdd:pfam00083 241 SWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLS 287
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 32-287 1.31e-36

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 135.01  E-value: 1.31e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  32 AAALGPLSFGFALGYSSPAIPSLrrtaPPALRLGDNA--ASWFGAVVTLGAAAGGILGGWLLDRAGRKLSLLLCTVPFVT 109
Cdd:cd17315     1 VAALGGLLFGYDLGVINGALLYI----AKDLGFGLSTslQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 110 GFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILLAYVAGWVLE------WRW 183
Cdd:cd17315    77 GALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSlsppgwWRL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 184 LAVLGCVPPTLMLLLMCYMPETprflltqhqyqeamaalrflwgseegweeppvgaehqgfqlallrrpgiyKPLIIGIS 263
Cdd:cd17315   157 MFALAAVPALLQLLLMFFLPES--------------------------------------------------RALLVGVG 186

                         250       260
                  ....*....|....*....|....
gi 1249618446 264 LMVFQQLSGVNAIMFYANSIFEEA 287
Cdd:cd17315   187 LQLLQQLTGINAVMYYAPTIFKSA 210
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 25-290 1.20e-35

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 134.39  E-value: 1.20e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  25 RVFLASFAAALGPLSFGFALGYSSPAIPSLRRTAPPALRLGDNAASWFGAVVTLGAAAGGI----LGGWLLDRAGRKLSL 100
Cdd:TIGR00879  25 KVALLSLIAAIGGLMFGYDTGVIGGALALPAFEFKFTSANSDSYSSSLWGLVVSIFLVGGFigalFAGWLSDRFGRKKSL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 101 LLCTVPFVTGFAVITAAR---DVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILLAY---- 173
Cdd:TIGR00879 105 LIIALLFVIGAILMGLAAfalSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYgfgs 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 174 ---VAGWVLEWRWLAVLGCVPPTLMLLLMCYMPETPRFLLTQHQYQEAMAALRFLWGSEEgwEEPPVGAEHQGFQLALLR 250
Cdd:TIGR00879 185 gkvSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLARLRGTSG--EDKELLDELELIDIKRSI 262

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1249618446 251 R---------------PGIYKPLIIGISLMVFQQLSGVNAIMFYANSIFEEAKFK 290
Cdd:TIGR00879 263 EkrsvqpswgslfsstRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVS 317
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 28-291 3.20e-34

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 128.84  E-value: 3.20e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  28 LASFAAALGPLSFGFALGYSSPAIPSLRRTAPpalrLGDNAASWFGAVVTLGAAAGGILGGWLLDRAGRKLSLLLCTVPF 107
Cdd:cd17359     1 LISLVAALGGLLFGYDTGVINGALPFLQTDFN----LTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLF 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 108 VTGfAVITA-ARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILLAYVAGWVLE------ 180
Cdd:cd17359    77 FIS-ALGSAfSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIAnaggad 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 181 ------WRWLAVLGCVPPTLMLLLMCYMPETPRFLLTQHQyqeamaalrflwgseegweeppvgaehqgfqlallrrpgi 254
Cdd:cd17359   156 wlgaegWRWMLGLEAIPAILFLLGMLFIPESPRWLVSKGK---------------------------------------- 195

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1249618446 255 yKPLIIGISLMVFQQLSGVNAIMFYANSIFEEAKFKA 291
Cdd:cd17359   196 -PILIIGIGLAIFQQFVGINVIFYYGPEIFQNAGFSE 231
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 32-290 3.24e-31

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 120.45  E-value: 3.24e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  32 AAALGPLSFGFALGYSSPAIPSLRRtappALRLGDNAASWFGAVVTLGAAAGGILGG---WLLDRAGRKLSLLLCTVPFV 108
Cdd:cd17360     1 FAGIGGFLFGYDTGVISGALLYIKD----DLGEVVLSTGWQELIVSSTVAGAAVGAAiggWLNDRFGRRPCILLADALFT 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 109 TGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILLAYVAGWVLE-----WRW 183
Cdd:cd17360    77 IGAIVMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSylpggWRW 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 184 LAVLGCVPPTLMLLLMCYMPETPrflltqhqyqeamaalrflwgseegweeppvgaehqgfqlallRRPGIYKPLIIGIS 263
Cdd:cd17360   157 MLGLAAVPAVLQFIGLLFLPESP-------------------------------------------RWPSTRRALIVGCG 193

                         250       260
                  ....*....|....*....|....*..
gi 1249618446 264 LMVFQQLSGVNAIMFYANSIFEEAKFK 290
Cdd:cd17360   194 LQAFQQFSGINTVMYYSATILQMAGFK 220
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 90-290 9.11e-28

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 112.35  E-value: 9.11e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  90 LLDRAGRKLSLLLCTVPFVTGFAVITAAR---DVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVV 166
Cdd:cd17357    72 LANRFGRKNGLLISNALLVVSSLLMFLSKsakSPELLIFGRFLVGIACGLSTGFVPMYLQEISPSELRGALGSLTQIGVT 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 167 TGILLA------YVAGWVLEWRWLAVLGCVPPTLMLLLMCYMPETPRFLL-TQHQYQEAMAALRFLWGSEEgwEEPPVGA 239
Cdd:cd17357   152 LGILLGqvfglpSVLGTETLWPYLLFFPGIPALLQLAALPFFPESPKFLLiSKGDEEEAEKSLKFLRGIED--DVDQELE 229

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1249618446 240 EHQGFQLA-----------LLRRPGIYKPLIIGISLMVFQQLSGVNAIMFYANSIFEEAKFK 290
Cdd:cd17357   230 EIKKESEQmgdqkqvslmqLLRDPSLRLPLLLVLVVSASQQFSGINAIFFYSTFIFENAGFS 291
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 89-287 1.48e-27

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 111.66  E-value: 1.48e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  89 WLLDRAGRKLSLLLCTVPFVTGFAVI---TAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMV 165
Cdd:cd17431    72 LFVNRFGRRNSMLYNNLLAFAGAALMglsKLAKSYEMLILGRFIIGLYCGLTTGLVPMYIGEISPTALRGALGTLHQLGI 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 166 VTGILLAYVAGwvLEW------RWLAVLGC--VPPTLMLLLMCYMPETPRFLL-TQHQYQEAMAALRFLWGS-------- 228
Cdd:cd17431   152 VVGILISQIFG--LEFilgteeLWPLLLGFtiVPAILQLALLPFCPESPRYLLiNRNEEEEAKSVLKKLRGTtdvsediq 229

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1249618446 229 EEGWEEPPVGAEHQGFQLALLRRPGIYKPLIIGISLMVFQQLSGVNAIMFYANSIFEEA 287
Cdd:cd17431   230 EMKEESRQMMREKKVTILELFRSSSYRQPIIIAIVLQLSQQLSGINAVFYYSTSIFEKA 288
xylE PRK10077
D-xylose transporter XylE; Provisional
 24-287 4.22e-26

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 107.86  E-value: 4.22e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  24 RRVFLASFAAALGPLSFGFALGYSSPAIPSLRRTAPPALRLG-DNAASWFGAVVTLGA---AAGGILGGWLLDRAGRKLS 99
Cdd:PRK10077    8 SYIFSITLVATLGGLLFGYDTAVISGTVESLNTVFVAPQNLSeSAANSLLGFCVASALigcIIGGALGGYCSNRFGRRDS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 100 LLLCTVPFVT----------GFAVITAARDVWMLLGGRLLTGLACGV--ASLVAPVYISEIAYPAVRGLLGSCVQLMVVT 167
Cdd:PRK10077   88 LKIAAVLFFIsalgsawpefGFTSIGPDNTGYVPEFVIYRIIGGIGVglASMLSPMYIAEIAPAHIRGKLVSFNQFAIIF 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 168 GILLAYVAGWVLE------------WRWLAVLGCVPPTLMLLLMCYMPETPRFLLTQHQYQEAMAALRFLWGSEEGweep 235
Cdd:PRK10077  168 GQLVVYFVNYFIArsgdaswlntdgWRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILRKIMGNTLA---- 243

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 236 pvGAEHQGFQLALLRRPGIYKPL--------IIGISLMVFQQLSGVNAIMFYANSIFEEA 287
Cdd:PRK10077  244 --TQALQEIKHSLDHGRKTGGKLlmfgvgviVIGVMLSVFQQFVGINVVLYYAPEIFKTL 301
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 90-287 1.40e-22

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 97.69  E-value: 1.40e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  90 LLDRAGRKLSLLLCTVpfvtgFAVITA--------ARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCV 161
Cdd:cd17432    73 LVIRLGRKGTLLLNNI-----FAIVAAilmglskiAKSFEMIIVGRFLVGINAGISLNVVPMYLGESAPKNLRGAVGLVP 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 162 QLMVVTGILLAYVAGW--VL----EWRWLAVLGCVPPTLMLLLMCYMPETPRFLLTQ-HQYQEAMAALRFLWGSEEGWEE 234
Cdd:cd17432   148 AIFITLGILLGQVLGLreLLgneeGWPLLLALTGVPALLQLLTLPFFPESPRYLLIEkGDEEAARKALQRLRGKEDVDDE 227

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1249618446 235 -PPVGAEHQGFQ-------LALLRRPGIYKPLIIGISLMVFQQLSGVNAIMFYANSIFEEA 287
Cdd:cd17432   228 mEEMLEEQRAEKgvgtvsvLELFRDRSVRWQLISIIVLMAGQQLCGINAIYFYADSIFLEA 288
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 33-291 7.66e-22

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 94.73  E-value: 7.66e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  33 AALGPLSFGFALGYSSPAIPSLRRtapPALRLGDN------------AASWFGAVVTLGAAAGgilggwLLDRAGRKLSL 100
Cdd:cd17362     2 PALGGLLFGYDIGATSGALLSITS---PALSGTDWynlsslqsglvvSGSLLGALLGSLVAGA------LIDRLGRRKEL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 101 LLCTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILLAYVAGWVLE 180
Cdd:cd17362    73 ILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFA 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 181 -----WRWLAVLGCVPPTLMLLLMCYMPETPRFlltqhqyqeamaalrflwgseegweeppvgaehqgfqlallrRPGIY 255
Cdd:cd17362   153 dvvggWRYMYGLAAPPALLLGIGMWFLPPSPRW------------------------------------------QGNYR 190

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1249618446 256 KPLIIGISLMVFQQLSGVNAIMFYANSIFEEAKFKA 291
Cdd:cd17362   191 KPLIIGLGLVLFQQITGQPSVLYYAATIFKSAGFSA 226
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 67-285 4.19e-21

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 93.08  E-value: 4.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  67 NAASWFGAVVTLGaaaggilggwLLDRAGRKLSLLLCTVPFVTGFAV-ITAARDVWMLLGGRLLTGLACGVASLVAPVYI 145
Cdd:cd17356    55 NLGSFFGALISSF----------LSDRIGRKKSIQIGCVIYIIGAIIqVAAIGKWYQLIVGRIIAGLGVGFASVLVPVYQ 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 146 SEIAYPAVRGLLGSCVQLMVVTGILLAYVAGWVLE-------WRWLAVLGCVPPTLMLLLMCYMPETPRFLltqhqyqea 218
Cdd:cd17356   125 SEVAPKHIRGTLVSLYQLAITIGILVAYCINYGTHkldgsaqWRIPLGLQIVWGLLLLIGMFFLPESPRWL--------- 195

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1249618446 219 maalrflwgseegweeppvgaehqgfqlallrrpgiyKPLIIGISLMVFQQLSGVNAIMFYANSIFE 285
Cdd:cd17356   196 -------------------------------------YRTILGIMLQLFQQLTGINYFFYYGTTIFQ 225
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
 89-284 3.81e-19

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 87.31  E-value: 3.81e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  89 WLLDRAGRKLSLLLCTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTG 168
Cdd:cd17361    73 YVTRKWGRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGALNIGFQLAITIG 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 169 ILLAYVAGWVLE------WRWLAVLGCVPPTLMLLLMCYMPETPRFlltqhqyqeamaalrflwgseegweeppvgaehq 242
Cdd:cd17361   153 ILIANLINYGTSkikpngWRLSLGLAAVPALILLLGSLFLPETPNS---------------------------------- 198

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1249618446 243 gfqlallrrpgiyKPLIIGISLMVFQQLSGVNAIMFYANSIF 284
Cdd:cd17361   199 -------------PQLVIAILIPFFQQLTGINVIMFYAPVLF 227
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
 92-290 2.93e-14

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 72.82  E-value: 2.93e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  92 DRAGRKLSLLLCTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILL 171
Cdd:cd17437    57 DWIGRRYTIALAALIFFVGALLMGVAPNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEIFINIGILL 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 172 AYVAGWV-------LEWRWLAVLGCVPPTLMLLLMCYMPETPRFlltqhqyqeamaalrflwgseegweeppvgaehqgf 244
Cdd:cd17437   137 GYVSNYAfsglplhVGWRLMLGVGAVPSLFLAIGVLAMPESPRW------------------------------------ 180

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1249618446 245 qlallrRPGIYKPLIIGISLMVFQQLSGVNAIMFYANSIFEEAKFK 290
Cdd:cd17437   181 ------TPAVRRMLIAALGIHFFQQASGIDAVVLYSPRIFKKAGIK 220
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 28-301 1.83e-13

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 70.21  E-value: 1.83e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  28 LASFAAALGPLSFGFALGYSSPAIPSLR----------RTAPPALRLGDNAASWFGAVvtlgaaaggilggwLLDRAGRK 97
Cdd:cd17435     1 LSSVTAAVSGLLVGYELGIISGALLQLRtllalscheqEMVVSSLLIGALLASLTGGV--------------LIDRYGRR 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  98 LSLLLCTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILLAYVAGW 177
Cdd:cd17435    67 TAIILTSCLLVLGSLLLVCSVSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILLAYISNY 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 178 VLE-----WRWLAVLGCVPPTLMLLLMCYMPETPRFLLTqhqyqeamaalrflwgseegweeppvgaehqgfqlallrRP 252
Cdd:cd17435   147 AFAnvsngWKYMFGLVIPLAALQAIAMYFLPPSPRFLVM---------------------------------------KD 187

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1249618446 253 GIYKPLIIGISLMVFQQLSGVNAIMFYANSIFEEAKFKALRWAGDPSPG 301
Cdd:cd17435   188 NMRARLLIGLTLVFFVQITGQPNILFYASTVLKSVGFQSNEAASLASTG 236
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 28-290 2.86e-11

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 63.67  E-value: 2.86e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  28 LASFAAALGPLSFGFALGYSSPAIPSLR----------RTAPPALRLGDNAASWFGAvvtlgaaaggilggWLLDRAGRK 97
Cdd:cd17436     1 LTATVSLLGGLTFGYELGIISGALLQLQtdfslscfeqEALVSALLIGALLASLIGG--------------FLIDRHGRR 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  98 LSLLLCTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILLAYVAGW 177
Cdd:cd17436    67 TSILGSNLVLLAGSLILTLAGSFFWLVIGRAVVGFAISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVGILISYALNY 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 178 VLE-----WRWLAVLGCVPPTLMLLLMCYMPETPRFLLTqhqyqeamaalrflwgseegweeppvgaehqgfqlallrRP 252
Cdd:cd17436   147 FFSnvltgWRYMFGLAIIPAAIQFASILLLPKKPEVLNI---------------------------------------KD 187

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1249618446 253 GIYKPLIIGISLMVFQQLSGVNAIMFYANSIFEEAKFK 290
Cdd:cd17436   188 NMRRRTLVGLGLVLFQQFTGQPNVLCYASTIFRSVGFQ 225
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 17-210 9.66e-09

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 55.59  E-value: 9.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  17 EARTPRGRRVFLASFAAALGPLSFGFALGYSSPAIPSLRRtappALRLGDNAASWFGAVVTLGAAAGGILGGWLLDRAGR 96
Cdd:COG0477     3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAA----DLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  97 KLSLLLCTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILLAYVAG 176
Cdd:COG0477    79 KRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLG 158

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1249618446 177 WVLE----WRWLAVLGCVPPTLMLLLMCYMPETPRFLL 210
Cdd:COG0477   159 GLLVaalgWRWIFLINAPLGLLALVLRLRLPESRGLLL 196
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 90-223 8.95e-08

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 53.48  E-value: 8.95e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  90 LLDRAGRKLSLLLCTVpFVTGFAVITA-ARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTG 168
Cdd:TIGR00898 150 LSDRFGRKKVLLLSTL-VTAVSGVLTAfSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLG 228

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1249618446 169 -ILLAYVAGWVLEWRWLAVLGCVPPTLMLLLMCYMPETPRFLLTQHQYQEAMAALR 223
Cdd:TIGR00898 229 lVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQ 284
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
20-207 9.65e-07

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 49.97  E-value: 9.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  20 TPRGRRVFLASFAAALGPLSFGFALGYSSPAIPSLRRtappALRLGDNAASWFGAVVTLGAAAGGILGGWLLDRAGRKLS 99
Cdd:COG2814     2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAA----DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 100 LLLCTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILLA-YVAGWV 178
Cdd:COG2814    78 LLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGpLLGGLL 157

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1249618446 179 LE---WRWLAVLGCVPPTLMLLLM-CYMPETPR 207
Cdd:COG2814   158 ADlfgWRWVFLVNAVLALLALLLLlRLLPESRP 190
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 89-203 3.14e-05

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 44.88  E-value: 3.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  89 WLLDRAGRKLSLLLCTVpFVTGFAVITA-ARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVT 167
Cdd:cd17317    47 YLADRFGRRPVLLLGLV-LQIVCGVLSAfSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWAL 125

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1249618446 168 G-ILLAYVAGWVLEWRWLAVLGCVPPTLMLLLMCYMP 203
Cdd:cd17317   126 GyMLLALLAYLIRDWRWLQLAISLPGLLFLLLLWWLP 162
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 31-198 1.02e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 43.36  E-value: 1.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  31 FAAALGPLSFGFALGYSSPAIPSLRRTAPPALRLGDnaASWFGAVVTLGAAAGGILGGWLLDRAGRKLSLLLCTVPFVTG 110
Cdd:cd17316     2 LLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQ--TGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 111 FAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILLAYVAGWVLE--------WR 182
Cdd:cd17316    80 TLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIpllsgdwgWR 159

                         170
                  ....*....|....*.
gi 1249618446 183 WLAVLGCVPPTLMLLL 198
Cdd:cd17316   160 ILFLIGALPALLALLL 175
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 33-289 1.14e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 43.57  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  33 AALGPLSFGFALGYSSPAIPSLRRtappALRLGDNAASWFGAVVTLGAAAGGILGGWLLDRAGRKLSLLLCTVPFVTGFA 112
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQ----SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGAL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 113 VITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRG-LLGSCVQLMVVTGILLAYVAGWVLE-----WRWLAV 186
Cdd:cd06174    77 LFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGrALGLLQAFGSVGGILGPLLGGILASslgfgWRAVFL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 187 LGCVPPTLMLLLMCYMPETPRFLltqhqyqeamaalrflwgseegwEEPPVGAEHQGFQLALLRRPGIYKPLIIGISLMV 266
Cdd:cd06174   157 IAAALALLAAILLLLVVPDPPES-----------------------ARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIF 213

                         250       260
                  ....*....|....*....|...
gi 1249618446 267 FQQLSGVNAIMFYANSIFEEAKF 289
Cdd:cd06174   214 LVNLAYYSFSTLLPLFLLDLGGL 236
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 42-223 1.95e-04

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 43.04  E-value: 1.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  42 FALGYSSPaipslrrTAPPALRLGDNAASWFGAVVTLGAAAGGILGGWLLDRAGRKLSLLLCT---------VPFVTGFA 112
Cdd:TIGR01299 184 FVVGFVLP-------SAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLsvngffaffSSFVQGYG 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 113 VITAARdvwmllggrllTGLACGVASLVAPV--YISEIAYPAVRG--LLGSCVQLMvVTGILLAYVA-------GWVLE- 180
Cdd:TIGR01299 257 FFLFCR-----------LLSGFGIGGAIPIVfsYFAEFLAQEKRGehLSWLCMFWM-IGGIYAAAMAwaiiphyGWSFQm 324

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1249618446 181 --------WRWLAVLGCVPPTLMLLLMCYMPETPRFLLTQHQYQEAMAALR 223
Cdd:TIGR01299 325 gsayqfhsWRVFVIVCAFPCVFAIGALTFMPESPRFFLENGKHDEAWMILK 375
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 89-209 5.31e-04

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 41.57  E-value: 5.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  89 WLLDRAGRKLSLLLCTVPFvTGFAVITA-ARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVT 167
Cdd:TIGR00895  74 PLADRIGRRRVLLWSILLF-SVFTLLCAlATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPI 152

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1249618446 168 GILLA-YVAGW---VLEWRWLAVLGCVPPTLML-LLMCYMPETPRFL 209
Cdd:TIGR00895 153 GAAVGgFLAGWlipVFGWRSLFYVGGIAPLLLLlLLMRFLPESIDFL 199
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
3-172 1.20e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 40.34  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446   3 PEDPQETQPLLRPPEARTPRGRRVFLASFAAALGPLSFGFALGYSSPAIPSlrrtappALRLGDNAASWFGAVVTLGAAA 82
Cdd:COG2814   186 PESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQE-------VLGLSASAAGLLLALFGLGGVL 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  83 GGILGGWLLDRAGRKLSLLLCTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQ 162
Cdd:COG2814   259 GALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYN 338

                         170
                  ....*....|
gi 1249618446 163 LMVVTGILLA 172
Cdd:COG2814   339 SAFFLGGPLA 348
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
 66-223 1.21e-03

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 40.28  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  66 DNAASWFGAVVTLGAAAGGILGGWLLDRAGRKLSLLLCT---------VPFVTGFAVITAARdvwmllggrLLTGLACGV 136
Cdd:cd17440    33 NSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMsvngffaflSSFVQGYGLFLFCR---------LLSGFGIGG 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 137 ASLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILLAYVAGWVL-----------------EWRWLAVLGCVPPTLMLLLM 199
Cdd:cd17440   104 AVPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIiphygwsfsmgsayqfhSWRVFVIVCALPCVSSVVAL 183

                         170       180
                  ....*....|....*....|....
gi 1249618446 200 CYMPETPRFLLTQHQYQEAMAALR 223
Cdd:cd17440   184 TFMPESPRFLLEVGKHDEAWMILK 207
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
20-199 4.44e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 38.31  E-value: 4.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  20 TPRGRRVFLASFAAALGPLSFGFALGYSSPAIPSLRRtappALRLGDNAASWFGAVVTLGAAAGGILGGWLLDRAGRKLS 99
Cdd:COG2271     2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQA----DLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 100 LLLCTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILLAY-VAGWV 178
Cdd:COG2271    78 LAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPpLLGWL 157

                         170       180
                  ....*....|....*....|....
gi 1249618446 179 LE---WRWLAVLGCVPPTLMLLLM 199
Cdd:COG2271   158 LAafgWRAAFLILGLPGLLLALLR 181
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 89-217 6.80e-03

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 38.05  E-value: 6.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  89 WLLDRAGRKLSLLLCtvpfVTGFAVITA----ARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLM 164
Cdd:cd17371    56 ILADRFGRVRVLVIT----ILLFAVFTLlcgfAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSG 131

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1249618446 165 VVTGILLA-YVAGWVLE-------WRWLAVLGCVPPTLMLLLMCYMPETPRFLLTQHQYQE 217
Cdd:cd17371   132 WAVGWLLAtLLAALLFPllppeiaWRVLFLLGALPALLVLFIRRFVKEPPQWQAARAARRH 192
MFS_1 pfam07690
Major Facilitator Superfamily;
34-228 8.31e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 37.40  E-value: 8.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446  34 ALGPLSFGFALGYSSPAIPSLRRTAppaLRLGDNAASWFGAVVTLGAAAGGILGGWLLDRAGRKLSLLLCTVPFVTGFAV 113
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLLLAED---LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618446 114 ITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILLAYVAG----WVLEWRWlAVLGC 189
Cdd:pfam07690  79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGgllaSLFGWRA-AFLIL 157

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1249618446 190 VPPTLMLLLMCYMPETPRFLLTQHQYQEAMAALRFLWGS 228
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKA 196
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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