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Conserved domains on  [gi|1240431762|ref|NP_001342060|]
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zinc finger protein 819 isoform 2 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
217-455 2.50e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 2.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240431762 217 TNPLETHFICHICGKSFLQKSELSFHPGTDRgetHHGCPGCRKSLPSTSSLQARHGTH------TKEKPYRCPDCGKSFS 290
Cdd:COG5048   224 SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSS---SSASESPRSSLPTASSQSSSPNESdsssekGFSLPIKSKQCNISFS 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240431762 291 YASHLKIHLR--IHTGE--RPYVC--SDCGKAFSQKSVLTTHRRIHTGERPYTCnhcgklfVYASDLKKHSrfhtgekpy 364
Cdd:COG5048   301 RSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKE-------KLLNSSSKFS--------- 364

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240431762 365 ecrdcgKLFNNKSHLPVHYRIHTGEKPYRCCD---CGKSFRRKSHLKVHSRTHTGEKPYEC--PDCGRAFSHSSVLSTHQ 439
Cdd:COG5048   365 ------PLLNNEPPQSLQQYKDLKNDKKSETLsnsCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHK 438

                         250
                  ....*....|....*.
gi 1240431762 440 RIHTGERPYLCSDCGK 455
Cdd:COG5048   439 KIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
463-487 5.06e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.06e-04
                          10        20
                  ....*....|....*....|....*
gi 1240431762 463 LNEHRRIHTGEKPYVCSECGKAFSC 487
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
217-455 2.50e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 2.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240431762 217 TNPLETHFICHICGKSFLQKSELSFHPGTDRgetHHGCPGCRKSLPSTSSLQARHGTH------TKEKPYRCPDCGKSFS 290
Cdd:COG5048   224 SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSS---SSASESPRSSLPTASSQSSSPNESdsssekGFSLPIKSKQCNISFS 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240431762 291 YASHLKIHLR--IHTGE--RPYVC--SDCGKAFSQKSVLTTHRRIHTGERPYTCnhcgklfVYASDLKKHSrfhtgekpy 364
Cdd:COG5048   301 RSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKE-------KLLNSSSKFS--------- 364

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240431762 365 ecrdcgKLFNNKSHLPVHYRIHTGEKPYRCCD---CGKSFRRKSHLKVHSRTHTGEKPYEC--PDCGRAFSHSSVLSTHQ 439
Cdd:COG5048   365 ------PLLNNEPPQSLQQYKDLKNDKKSETLsnsCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHK 438

                         250
                  ....*....|....*.
gi 1240431762 440 RIHTGERPYLCSDCGK 455
Cdd:COG5048   439 KIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
406-431 1.15e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.15e-04
                          10        20
                  ....*....|....*....|....*.
gi 1240431762 406 HLKVHSRTHTGEKPYECPDCGRAFSH 431
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
463-487 5.06e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.06e-04
                          10        20
                  ....*....|....*....|....*
gi 1240431762 463 LNEHRRIHTGEKPYVCSECGKAFSC 487
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
217-455 2.50e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 2.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240431762 217 TNPLETHFICHICGKSFLQKSELSFHPGTDRgetHHGCPGCRKSLPSTSSLQARHGTH------TKEKPYRCPDCGKSFS 290
Cdd:COG5048   224 SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSS---SSASESPRSSLPTASSQSSSPNESdsssekGFSLPIKSKQCNISFS 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240431762 291 YASHLKIHLR--IHTGE--RPYVC--SDCGKAFSQKSVLTTHRRIHTGERPYTCnhcgklfVYASDLKKHSrfhtgekpy 364
Cdd:COG5048   301 RSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKE-------KLLNSSSKFS--------- 364

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240431762 365 ecrdcgKLFNNKSHLPVHYRIHTGEKPYRCCD---CGKSFRRKSHLKVHSRTHTGEKPYEC--PDCGRAFSHSSVLSTHQ 439
Cdd:COG5048   365 ------PLLNNEPPQSLQQYKDLKNDKKSETLsnsCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHK 438

                         250
                  ....*....|....*.
gi 1240431762 440 RIHTGERPYLCSDCGK 455
Cdd:COG5048   439 KIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
258-511 4.39e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 4.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240431762 258 RKSLPSTSSLQARHGTHTKEKPYRCPDCgKSFSYASHLKIHLRIHTGERPYVCSdcgkafSQKSVLTTHRRIHTGERPYT 337
Cdd:COG5048   191 NVSTSIPSSSENSPLSSSYSIPSSSSDQ-NLENSSSSLPLTTNSQLSPKSLLSQ------SPSSLSSSDSSSSASESPRS 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240431762 338 CNhCGKLFVYASDLKKHSRFHTG-EKPYECRDCGKLFNNKSHLPVHYR--IHTGE--KPYRCC--DCGKSFRRKSHLKVH 410
Cdd:COG5048   264 SL-PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRH 342

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240431762 411 SRTHTGEKPYECPDCGRAFSHSSVL-------STHQRIHTGERPYLCSD--CGKAMSSKAQLNEHRRIHTGEKPYVC--S 479
Cdd:COG5048   343 ILLHTSISPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCknP 422

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1240431762 480 ECGKAFSCRSSLQAHRRTHSREKPFVCHTCGK 511
Cdd:COG5048   423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
276-531 5.09e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 5.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240431762 276 KEKPYRCPDCGKSFSYASHLKIHLRIHTGERPYVCSD--CGKAFSQKSVLTTHRRIHTGERPYTC--------------- 338
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNskslplsnskassss 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240431762 339 -NHCGKLFVYASDLKKHS-------------RFHTGEKPYECRDCGKLFNN----------------------KSHLPVH 382
Cdd:COG5048   110 lSSSSSNSNDNNLLSSHSlppssrdpqlpdlLSISNLRNNPLPGNNSSSVNtpqsnslhpplpanslskdpssNLSLLIS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240431762 383 YRIHTGEKPYRCCDCGKSFRRKSHLKVHSRTHTGEKPYECPDCGRAFSHSSVLSTHQRIHTGERPYLCSDCGKAMSSKAQ 462
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240431762 463 LNEHRRIHTGE-------KPYVCSECGKAFSCRSSLQAHRRT--HSRE--KPFVC--HTCGKGFLHKSQLSSHQQTHTGE 529
Cdd:COG5048   270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSI 349


                  ..
gi 1240431762 530 NP 531
Cdd:COG5048   350 SP 351
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
251-531 7.46e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 7.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240431762 251 HHGCPGCRKSLPSTSSLQARHGTHTKEKPyrcpdcgkSFSYASHLKIHLRIHTGERPYVCSDCGKAFSQKSVLTTHRRIH 330
Cdd:COG5048   151 LPGNNSSSVNTPQSNSLHPPLPANSLSKD--------PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLEN 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240431762 331 -TGERPYTCNHCGK----LFVYASDLKKHSRFHTGEKPYECRDCGKLFNNKSHLPVHYRIHTG-EKPYRCCDCGKSFRRK 404
Cdd:COG5048   223 sSSSLPLTTNSQLSpkslLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRS 302

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240431762 405 SHLKVHSRT--HTGE--KPYECP--DCGRAFSHSSVLSTHQRIHTGERP---YLCSDCGKAMSSKAQLNE----HRRIHT 471
Cdd:COG5048   303 SPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPakeKLLNSSSKFSPLLNNEPPqslqQYKDLK 382

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1240431762 472 GEKPYVC--SECGKAFSCRSSLQAHRRTHSREKPFVCH--TCGKGFLHKSQLSSHQQTHTGENP 531
Cdd:COG5048   383 NDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAP 446
zf-H2C2_2 pfam13465
Zinc-finger double domain;
406-431 1.15e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.15e-04
                          10        20
                  ....*....|....*....|....*.
gi 1240431762 406 HLKVHSRTHTGEKPYECPDCGRAFSH 431
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
294-319 4.96e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.96e-04
                          10        20
                  ....*....|....*....|....*.
gi 1240431762 294 HLKIHLRIHTGERPYVCSDCGKAFSQ 319
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
463-487 5.06e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.06e-04
                          10        20
                  ....*....|....*....|....*
gi 1240431762 463 LNEHRRIHTGEKPYVCSECGKAFSC 487
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 280-302 7.48e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 7.48e-04
                          10        20
                  ....*....|....*....|...
gi 1240431762 280 YRCPDCGKSFSYASHLKIHLRIH 302
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
350-375 1.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.07e-03
                          10        20
                  ....*....|....*....|....*.
gi 1240431762 350 DLKKHSRFHTGEKPYECRDCGKLFNN 375
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 304-382 1.53e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240431762 304 GERPYVCS--DCGKAFSQKSVLTTHRrIHtgerpytcNHCGKLFVYASDLKKHSRFHTGEKPYECRDCGKLFNNKSHLPV 381
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM-LH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  .
gi 1240431762 382 H 382
Cdd:COG5189   417 H 417
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 392-414 1.53e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.53e-03
                          10        20
                  ....*....|....*....|...
gi 1240431762 392 YRCCDCGKSFRRKSHLKVHSRTH 414
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 416-499 9.88e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.55  E-value: 9.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240431762 416 GEKPYECP--DCGRAFSHSSVLSTHqRIHtgerpylcSDCGKAMSSKAQLNEHRRIHTGEKPYVCSECGKAFSCRSSLQA 493
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1240431762 494 HrRTHS 499
Cdd:COG5189   417 H-RKHS 421
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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