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Conserved domains on  [gi|1222020091|ref|NP_001340845|]
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beta-galactoside alpha-2,6-sialyltransferase 1 isoform a [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 137-401 0e+00

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467713  Cd Length: 266  Bit Score: 580.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 137 AEALRCHLRDHVNVSMVEVTDFPFNTSEWEGYLPKESIRTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPT 216
Cdd:cd23985     1 AEELLCELKDKVNVSMLEGTDFPFNTSEWEGYLPKKSLREEVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 217 ANFQQDVGTKTTIRLMNSQLVTTEKR-FLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYNFFNNYKTYRKLHPNQPFYI 295
Cdd:cd23985    81 AGFQQDVGTKTTIRLINSQLVTTEKHkFLKDSLYNEGILIVWDPAPYHSDIPEWYKNPDYNFFENYKTYRRLNPNQPFYI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 296 LKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYYQKFFDSACTMGAYHPLLYE 375
Cdd:cd23985   161 LHPQMQWELWDIIQENSPEEIQPNPPSSGMLGIILMMTLCDQVDVYEFLPSKRKTDVCHYYQKFFDRACTMGAYHPLLYE 240

                         250       260
                  ....*....|....*....|....*.
gi 1222020091 376 KNLVKHLNQGTDEDIYLLGKATLPGF 401
Cdd:cd23985   241 KNLVKHLNQGTDEDIYLLGKVTLPGF 266
 
Name Accession Description Interval E-value
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 137-401 0e+00

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 580.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 137 AEALRCHLRDHVNVSMVEVTDFPFNTSEWEGYLPKESIRTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPT 216
Cdd:cd23985     1 AEELLCELKDKVNVSMLEGTDFPFNTSEWEGYLPKKSLREEVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 217 ANFQQDVGTKTTIRLMNSQLVTTEKR-FLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYNFFNNYKTYRKLHPNQPFYI 295
Cdd:cd23985    81 AGFQQDVGTKTTIRLINSQLVTTEKHkFLKDSLYNEGILIVWDPAPYHSDIPEWYKNPDYNFFENYKTYRRLNPNQPFYI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 296 LKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYYQKFFDSACTMGAYHPLLYE 375
Cdd:cd23985   161 LHPQMQWELWDIIQENSPEEIQPNPPSSGMLGIILMMTLCDQVDVYEFLPSKRKTDVCHYYQKFFDRACTMGAYHPLLYE 240

                         250       260
                  ....*....|....*....|....*.
gi 1222020091 376 KNLVKHLNQGTDEDIYLLGKATLPGF 401
Cdd:cd23985   241 KNLVKHLNQGTDEDIYLLGKVTLPGF 266
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 169-384 2.17e-29

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 114.63  E-value: 2.17e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 169 LPKESiRTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMN--SQLVTTEKRFLKD 246
Cdd:pfam00777  32 LPKVS-PFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNpeSAIDSKYGNLGFS 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 247 SLYNEGILIV----------WDPS-VYHSDIPkwyqnpdyNFFNNYKTYRKLHPNQP---FYILKPqmpwelwDILQEI- 311
Cdd:pfam00777 111 HPRDPFVEFVlvpfkgrdllWLPAfLTKGNVS--------RSLRVLYTLKEVKIPVDpdkVLFLHP-------DFLRYVa 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 312 -----SPeEIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYYqkfFDSAC--TMGAY--HPLLYEKNLVKHL 382
Cdd:pfam00777 176 nfwlrSH-GLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHY---YDNVLmkKGGFYgvHDMPFEFKLLQKL 251


                  ..
gi 1222020091 383 NQ 384
Cdd:pfam00777 252 HK 253
 
Name Accession Description Interval E-value
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 137-401 0e+00

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 580.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 137 AEALRCHLRDHVNVSMVEVTDFPFNTSEWEGYLPKESIRTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPT 216
Cdd:cd23985     1 AEELLCELKDKVNVSMLEGTDFPFNTSEWEGYLPKKSLREEVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 217 ANFQQDVGTKTTIRLMNSQLVTTEKR-FLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYNFFNNYKTYRKLHPNQPFYI 295
Cdd:cd23985    81 AGFQQDVGTKTTIRLINSQLVTTEKHkFLKDSLYNEGILIVWDPAPYHSDIPEWYKNPDYNFFENYKTYRRLNPNQPFYI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 296 LKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYYQKFFDSACTMGAYHPLLYE 375
Cdd:cd23985   161 LHPQMQWELWDIIQENSPEEIQPNPPSSGMLGIILMMTLCDQVDVYEFLPSKRKTDVCHYYQKFFDRACTMGAYHPLLYE 240

                         250       260
                  ....*....|....*....|....*.
gi 1222020091 376 KNLVKHLNQGTDEDIYLLGKATLPGF 401
Cdd:cd23985   241 KNLVKHLNQGTDEDIYLLGKVTLPGF 266
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 137-401 6.75e-150

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 425.15  E-value: 6.75e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 137 AEALRCHLRDHVNVSMVEVTDFPFNTSEWEGYLPKESIRTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPT 216
Cdd:cd23968     1 SEDLLCRLKKAAPFSTLRKTTSPFKDLLSLRYPFPESSLENTKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 217 ANFQQDVGTKTTIRLMNSQLVT-TEKRFLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYNFFNNYKTYRKLHPNQPFYI 295
Cdd:cd23968    81 KGFEKDVGSKTTLRLINSQILSkPEFNFLTDPLYRNVTLLVWDPSSYNVNLEKWYKKPDFDFFPNYIKYRRRHPEEPFYL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 296 LKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYYQKFFDSACTMGAYHPLLYE 375
Cdd:cd23968   161 IDPRFLWRLWDILQEYTPEKIKPNPPSSGFIGIVLMLHLCDWVDVYEYVPSVRQTDRCHYYDVEKDLACTLGAWHPLAAE 240

                         250       260
                  ....*....|....*....|....*.
gi 1222020091 376 KNLVKHLNQGTDEDIYLLGKATLPGF 401
Cdd:cd23968   241 KLLVRHLNVGSDDDIFRKGRATLPGF 266
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 134-401 6.52e-124

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 359.15  E-value: 6.52e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 134 KFSAEALRCHLRDHVNVSMVEVTDFPFNTSEWEGYLPKESI-RTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFN 212
Cdd:cd23986     1 KLSRQELLCELKKRVQVRTLDGKEAPFSALGWEKYVPKIPLsKLHLRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 213 GAPTANFQQDVGTKTTIRLMNSQLVTTEK-RFLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYNFFNNYKTYRKLHPNQ 291
Cdd:cd23986    81 SAPTRGYEKDVGNKTTIRIINSQILTNPNhHFIDSSLYKDVILVAWDPAPYSANLHKWYKKPDYNLFTPYVQYRKRNPNQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 292 PFYILKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYYQKFFDSACTMGAYHP 371
Cdd:cd23986   161 PFYILHPKFIWQLWDIIQENTQEKIQPNPPSSGFIGILIMMSMCREVHVYEYIPSVRQTDLCHYHERYYDAACTLGAYHP 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1222020091 372 LLYEKNLVKHLNQGTDEDIYLLGKATLPGF 401
Cdd:cd23986   241 LLYEKLLIQRMNKGTEDDLYRKGKVILPGF 270
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 184-382 2.63e-54

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 178.33  E-value: 2.63e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 184 CAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLV-----TTEKRFLKDSLYNEGILIVWD 258
Cdd:cd19952     1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAgfylrGPRCGCHPLPLEEEVVLILSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 259 PSVYhsdipkwyqnpdynFFNNYKTYRKLHPNQPFYILK--PQMPWELWDILQEISPEEIQ-PNPPSSGMLGIIIMMTLC 335
Cdd:cd19952    81 AAAA--------------DFKRLKRRKKRHDNAVLLLTDpaPDLLSYVRKRLEKLGLKSFFgGNAPSSGLLAVLLALQLC 146

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1222020091 336 DQVDIYEF--LPSKRKTDVCYYYQKFFDSActMGAYHPLLYEKNLVKHL 382
Cdd:cd19952   147 DSVDLYGFgvDSGHAPKVPYHYYDLVEAEE--GTAVHSFDLEAELLRAL 193
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 169-384 2.17e-29

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 114.63  E-value: 2.17e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 169 LPKESiRTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMN--SQLVTTEKRFLKD 246
Cdd:pfam00777  32 LPKVS-PFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNpeSAIDSKYGNLGFS 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 247 SLYNEGILIV----------WDPS-VYHSDIPkwyqnpdyNFFNNYKTYRKLHPNQP---FYILKPqmpwelwDILQEI- 311
Cdd:pfam00777 111 HPRDPFVEFVlvpfkgrdllWLPAfLTKGNVS--------RSLRVLYTLKEVKIPVDpdkVLFLHP-------DFLRYVa 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 312 -----SPeEIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYYqkfFDSAC--TMGAY--HPLLYEKNLVKHL 382
Cdd:pfam00777 176 nfwlrSH-GLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHY---YDNVLmkKGGFYgvHDMPFEFKLLQKL 251


                  ..
gi 1222020091 383 NQ 384
Cdd:pfam00777 252 HK 253
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 162-358 2.72e-25

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 103.88  E-value: 2.72e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 162 TSEWEGYLPKESIrTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKT--------TIRLMN 233
Cdd:cd23963    45 TKSLYELLPKTSP-FSHKRYKTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTnlttlnpsILKRRY 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 234 SQLVTTE--KRFLKD-SLYNEGILivwdpsVYHSDIPKWYQNPdynFFNNYKTYRKLHPNQPFYILKPQMPWELWDILQE 310
Cdd:cd23963   124 NSLKKNRdrDKFLNRlKEYNGSIL------WYPKFSFKSSTNL---LLKAARALKKNGLNLTVVYSNPEHFLAVQKFWKR 194

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1222020091 311 ISPEeiqpNPPSSGMLGIIIMMTLCDQVDIYEFLP---SKRKTDVCY-YYQK 358
Cdd:cd23963   195 RGLE----KRPSTGLYLVSLALTFCDEIHLYGFWPfptDPNGRPVPYhYYDD 242
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 182-370 2.20e-24

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 100.01  E-value: 2.20e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 182 GRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLM---NSQLVTTEKRFLKDSLYNEGILIVWD 258
Cdd:cd23965     2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVshsSLPRLLRNAILLLAGTRAPTVVVFWG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 259 PSVYhsdipkwYQNPDYNFFNNYKTYRKLHPNQPFYILKPQMPWELWDILQ-------EISPEEIqpnppSSGMLGIIIM 331
Cdd:cd23965    82 PETK-------MNKDGAGKYNLLRSLSKKYPDVEFYSLTPEKMDYADELFEketgksrIKSGTWL-----STGWFTMLLA 149

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1222020091 332 MTLCDQVDIYEFLPSK-----RKTDVCY-YYQKFFDSACTMGAYH 370
Cdd:cd23965   150 LDVCDEIKVYGMVPENycrehPNSKVPYhYYEPGGLKECTYYNYH 194
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 183-382 9.77e-24

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 97.75  E-value: 9.77e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRlmnsqLVTTEKRFLKDSLYNEGILIVWDPsvY 262
Cdd:cd23967     4 RCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFR-----MFYPESAFRDPEEYDSDWLLVLVP--F 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 263 HSDIPKWYQ------NPDYNFFNNYKTYRKLH--PNQpFYILKPQMPWEL-WDILQEISPEEIQPNPPSSGMLGIIIMMT 333
Cdd:cd23967    77 KSMDLLWLQavikgkKPNGKGGFWKKIATSVPkpPKK-IRILNPYILQEAaFDLIGLPMNGKQGKNVPTTGIIAIVMALH 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1222020091 334 LCDQVDIYEF-LPSKRKTDVCYYYQKFFDSACTMGAYHPLLYEKNLVKHL 382
Cdd:cd23967   156 YCDEVDIAGFgYDPSDPNAPLHYYDSLTMKAIKRSWTHNVTKEKKYLKKL 205
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 183-382 7.34e-19

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 84.33  E-value: 7.34e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLM--NSQLVTTEKRFLKDSLYnegILIVWDPS 260
Cdd:cd23982     4 RCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFypESAQFDPGIENDPDTLL---VLVPFKPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 261 VYHsdipkWYqnpdYNFFNNYKTYRKLHPNQP----------FYILKPQMPWELWDILQEISPEEIQPNPPSSGMLGIII 330
Cdd:cd23982    81 DFY-----WL----YEILSNEKRVRKGFWKQPpriwdanpkqIRILNPYYTYVAATKLLQVPGQRKKKQKPTTGLLAITL 151

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1222020091 331 MMTLCDQVDIYEF---LPSKRKTDVCYYYQKFFDSacTMGAYHPLLYEKNLVKHL 382
Cdd:cd23982   152 ALHLCDEVHIAGFgypDNGNSNQPIHYYNQITLKS--MANSGHNLNAEAQAIQRL 204
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 182-370 3.13e-18

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 82.99  E-value: 3.13e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 182 GRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQ----LVTTEKRFLK---DSLYnegil 254
Cdd:cd23977     2 RRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTsvplLLRNQGYFFQqsrDTKY----- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 255 IVWDPSVYHSDIPKwyqNPDYNFFnnyKTYRKLHPNQPFYILKPQMPWELWDILQ-EISPEEIQPNP-PSSGMLGIIIMM 332
Cdd:cd23977    77 VIWGPERNMDRDGG---GKTYRAL---LTLAKMYPHLQVYTLTEEKMAYCDGVFQnETGKNRMKSGSfLSTGWFTMILAL 150

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1222020091 333 TLCDQVDIY-----EFLPSKRKTDVCY-YYQKFFDSACTMGAYH 370
Cdd:cd23977   151 ELCEEILVYgmvsdSYCRNKNHSSVPYhYYEKGRLDECRMYLVH 194
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 183-384 2.21e-17

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 81.92  E-value: 2.21e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTT--IRLMNSQLVTTEKRFL--KDSLYnegILIVWD 258
Cdd:cd23964    84 RCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSfyTFFPESLHNSLLKHVPqdKDTKY---LFIPFK 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 259 PSVYHS--DIPKWYQNPDYNFFNN--YKTYRKLHPNQPFYILKPqmpwelwDILQEI------SPEEiqpNPPSSGMLGI 328
Cdd:cd23964   161 IRDYDYldAVLSGKPVPDGCDKGKrpPPLFGPKLNATNVRLLHP-------DFIRYLfnrwlnSSTS---YRPTTGALML 230

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1222020091 329 IIMMTLCDQVDIYEFLPSKRKTDVcYYYQKFFDSACTMGAyHPLLYEKNLVKHLNQ 384
Cdd:cd23964   231 LTALHTCDQVSVYGFGYDPRFSLH-YYDKTFVKFTVFYAN-HDFTNERKLWRKLHE 284
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 184-382 4.03e-17

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 80.90  E-value: 4.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 184 CAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNS----------QLVTTEKRFLKDsLYNEGI 253
Cdd:cd23970    71 CAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNPsilekyynnlLTIQDRNNFFLS-LKKLDG 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 254 LIVWDPSV-YHSDIPKWYQNPDynFFNNYKTYRKLHPNQPFYIlkpqMPW--ELWDiLQEISPEEIqpnppSSGMLGIII 330
Cdd:cd23970   150 AILWIPAFfFHTSATVTRTLVD--FFVEHRGQLKVQLAWPGNI----MQHvnRYWK-TKHLSPKRL-----STGILMYTL 217

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1222020091 331 MMTLCDQVDIYEFLP---SKRKTDVCYYYQKFFDSACTMG--AYHPLLYEKNLVKHL 382
Cdd:cd23970   218 ASAICEEIHLYGFWPfgfDPTGTPLPYHYYDKKGTKFTTKwqESHQLPAEFVLLYKM 274
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 184-376 5.03e-16

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 77.22  E-value: 5.03e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 184 CAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSqlvTTEKRFLKD-----SLYNEGILIVWD 258
Cdd:cd23976    18 CALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAH---SSIQRILRNrnellNVSQGTVFIFWG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 259 PSVYHSDIPKWYqnpdynFFNNYKTYRKLHPNQPFYILKPQMPWELWDIL-QEISPEEIQPNP-PSSGMLGIIIMMTLCD 336
Cdd:cd23976    95 PSNYMRRDGKGL------VYNNLQLMNQILPKLKVYTITRHKMLQFDELFkRETGKDRKISNTwLSTGWFTMIIALELCD 168

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1222020091 337 QVDIY-----EFLPSKRKTDVCY-YYQKFFDSACTM---------GAYHPLLYEK 376
Cdd:cd23976   169 RINVYgmvppDFCRDPNHPSVPYhYYEPSGPDECTMyishergrkGSHHRFITEK 223
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 183-343 7.51e-16

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 76.94  E-value: 7.51e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMnsqlvttekrflkdslYNEGILIVwDPSVY 262
Cdd:cd23966    79 RCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFM----------------YPESAVDL-DPGVH 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 263 HSDIP------KWYQNPdynfFNNYKTYRKLHPNQPFYILKPqmpwelwDILQEISPE----------EIQPNPPSSGML 326
Cdd:cd23966   142 LVLVPfkvldlQWLISA----LTTGEITRTYTPVKRFIKADK-------DKVLVINPAfikyvhdnwtEHHGRYPSTGFL 210

                         170
                  ....*....|....*..
gi 1222020091 327 GIIIMMTLCDQVDIYEF 343
Cdd:cd23966   211 ALIFALHICDEVSVFGF 227
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 184-376 5.30e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 73.74  E-value: 5.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 184 CAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMN----SQLVTTEKRFLkdSLYNEGILIVWDP 259
Cdd:cd23978     4 CALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAhssvYRVLRRPQEFL--NRTPETTLIFWGP 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 260 SvyhsdiPKWYQNPDYNFFNNYKTYRKLHPNQPFYILKPQMPWELWDILQEISPEEIQPNPP--SSGMLGIIIMMTLCDQ 337
Cdd:cd23978    82 P------NKMQKDGKSNLFRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSwlSTGWFTMVIAVELCDN 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1222020091 338 VDIYEFLP----SKR----KTDVCYYYQKFFDSACT--------MGAYHPLLYEK 376
Cdd:cd23978   156 VHVYGMVPpnycSKRptpkKMPYHYYEPKGPDECVTyiqnehgrRGNHHRFITEK 210
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 183-382 1.40e-14

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 72.09  E-value: 1.40e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLVttekrfLKDSLYNEG----ILIVWD 258
Cdd:cd23984     4 KCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESI------FSDPSHYDPnttvVLIPFK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 259 PSVYH--SDIPKWYQNPDYNFFNnyKTYRKL--HPNQ-----PFYILKpqMPWELWDiLQEISPEEIQPNPPSSGMLGII 329
Cdd:cd23984    78 PHDLRwlLDLLMGKKVSAKGFWK--KPALNLiyKPNQirilnPFILRI--AAYELLH-FPKRFPKEKKPKHPTTGIIAIT 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1222020091 330 IMMTLCDQVDI----YEFLPSkrkTDVCYYYQKFFDSACTMGAYHPLLYEKNLVKHL 382
Cdd:cd23984   153 LALHICNEVHIagfkYDFSNL---NSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 184-356 1.54e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 73.22  E-value: 1.54e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 184 CAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLV----------TTEKRFLKD-SLYNEG 252
Cdd:cd23969    67 CAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPSVIphaygdlvnaTDKEKFVERlRQLGDS 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 253 ILivWDPSVYHSDIPKWYQNPDYNFFNNYKTYRKLHPNQPFYilkpQMPWELWdilqeiSPEEIQPNPPSSGMLGIIIMM 332
Cdd:cd23969   147 IL--WIPAFVSKGGEEHVQWTNEIILKHKLNVKTAYPPLRLN----HAIRGYW------LTTKFRIKRPSTGLLMYTLAT 214

                         170       180
                  ....*....|....*....|....*..
gi 1222020091 333 TLCDQVDIYEFLPSK---RKTDVCYYY 356
Cdd:cd23969   215 RFCDEIHLYGFYPFSedgNGRAVKYHY 241
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 183-343 9.07e-14

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 71.07  E-value: 9.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTirlmnSQLVTTEKrfLKDSLYNEGILIV------ 256
Cdd:cd23980    83 RCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTT-----HHFVYPES--FRELAQNVSMILVpfktld 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 257 --WDPS-VYHSDIPKWYqnpdynffnnYKTYRKLHPNQP-FYILKPQMPWELWD-ILQEispeeiQPNPPSSGMLGIIIM 331
Cdd:cd23980   156 leWVISaTTTGTISHTY----------VPVPRKIKVKKEkILIYHPAFIKYVFDrWLQG------HGRYPSTGILSVIFS 219

                         170
                  ....*....|..
gi 1222020091 332 MTLCDQVDIYEF 343
Cdd:cd23980   220 LHVCDEVDLYGF 231
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 183-343 1.44e-13

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 69.38  E-value: 1.44e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMnsqlvttekrflkdslYNEGILIVW---DP 259
Cdd:cd23983     4 RCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMT----------------YPEGAPKSEqeyDP 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 260 S------VYHSDIPKWYQNPDYN----------FFNNYKTYRKLHPNQpFYILKPQMPWEL-WDILQEISPEEI----QP 318
Cdd:cd23983    68 TslfvavLFKSVDFAWLKAMVKKeplsfwsrlfFWKEVADSIPLKPSQ-FRILNPLIIKETaLDILQYPEPQSRlwgwDK 146

                         170       180
                  ....*....|....*....|....*
gi 1222020091 319 NPPSSGMLGIIIMMTLCDQVDIYEF 343
Cdd:cd23983   147 NVPTLGVTAVVLATHLCDEVSLAGF 171
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 183-383 1.81e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 70.62  E-value: 1.81e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKT-----TIRLMNSQLVTTEKRFLKDSLYNEGILIVW 257
Cdd:cd23972    84 RCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTsfygfTVNTMKNSLISYWNLGFTRTPQGQDLQYIF 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 258 DPS------VYHSDI-----PKWYQNPD--YNFFN---NYKTYRKLHPNQPFYILKPQMPWELWDIlqeispEEIQPNPP 321
Cdd:cd23972   164 IPSdirdyvMLRSAIlgvpvPEGLDKGDrpHKYFGpeaSAKKFKLLHPDFISYLTDRFLKSKLLNT------HYGHLYMP 237

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1222020091 322 SSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYYQK------FFdsactmgAYHPLLYEKNLVKHLN 383
Cdd:cd23972   238 STGALMLLTALHTCDQVSAYGFITSNYWKFSDHYYERkkkplvFY-------ANHDMLLEAALWRRLH 298
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 175-377 8.70e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 68.63  E-value: 8.70e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 175 RTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKT------TIRLMNS-------------Q 235
Cdd:cd23974    78 PNGRSPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTsfytfsTNTLMNSlrayagvgfngppQ 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 236 LVTTEKRFLKDslYNEGILIVwDPSVYHSDI---PKWYQNPDYNFFNNYKT--YRKLHPNQPFY---------ILKPQMp 301
Cdd:cd23974   158 SKETRYIFLPD--HDRDYLLV-KAALTHTPIdrgRDKSKRPSKYFGKDVTAekFKIYHPDFIRYlrnrflwspILNTKQ- 233

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1222020091 302 welWDILQeispeeiqpnpPSSGMLGIIIMMTLCDQVDIYEFLpskrKTDVCYYYQKFFDSactmgAYHPLLYEKN 377
Cdd:cd23974   234 ---RDIYR-----------PSTGAVMLLAALHTCDQVSAYGFM----TPDYGKYSDHYYDK-----TYHKVVFYAN 286
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 169-345 1.12e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 67.67  E-value: 1.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 169 LPKESIrTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTaNFQQDVGTKTTIRLMN-SQLVT-----TEKR 242
Cdd:cd23971    53 LPKESP-FSNKPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPL-NDSKDVGSKTNLVTANpSILREkfhnlKKRR 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 243 --FLKD-SLYNEGILIV--------WDPS--VYH--SDIPKWyQNPdynFFnnyktyrkLHPNqpfYILKPQMPWELWDi 307
Cdd:cd23971   131 rpFVERmKVYGNALLLLpafsytsnTEPSlrALYtlEDFGSP-QKV---LF--------FNPE---YLRNLSRYWKSKG- 194

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1222020091 308 LQEISpeeiqpnpPSSGMLGIIIMMTLCDQVDIYEFLP 345
Cdd:cd23971   195 LKARR--------LSTGLMLVSAALELCENVHLYGFWP 224
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 169-362 3.35e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 66.50  E-value: 3.35e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 169 LPKESiRTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLV----------T 238
Cdd:cd23987    53 LPRTS-PLKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVqrafedlvneT 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 239 TEKRFLK--DSLyNEGILivWDPSVYH---SDIPKWYQN----PDYNFFNNYKTYRKLHPNQPFYIlkpqmpwelwdilq 309
Cdd:cd23987   132 WKEKFLQrlQSL-NGSIL--WIPAFMAkggEERVEWVNDlilkHHINVRTAYPSLRLLHAVRGYWL-------------- 194

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1222020091 310 eisPEEIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTD---VCYYYqkfFDS 362
Cdd:cd23987   195 ---TNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNqnpVKYHY---YDS 244
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 183-358 5.77e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 65.93  E-value: 5.77e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTI------RLMNSQLVTTEKRF------------- 243
Cdd:cd23973    85 RCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFyvhtahSITSSLMILQKRGFknipqdkdikyil 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 244 --------------LKDSLYNEGILIVWDPSVYHSD--IPKWY--QNPDynfFNNYKTYRKLHPNqpfyilkpQMPWELW 305
Cdd:cd23973   165 fpegprdyqwlealLKNKTIPSGAYYGRRPRSYFSGdfTEDKYlvLHPD---FLRYVKNRFLRSK--------TLKGKYW 233

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1222020091 306 DILQeispeeiqpnpPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYYQK 358
Cdd:cd23973   234 AIYR-----------PTTGAFLLLTALHLCDTVSAYGFITEDYRKYPDHYYDK 275
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 183-249 1.07e-11

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 63.79  E-value: 1.07e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1222020091 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQ-LVTTEKRFLKDSLY 249
Cdd:cd23981     4 RCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEgAIQKPEQYEKDSLF 71
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 184-363 2.06e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 64.21  E-value: 2.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 184 CAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLV----------TTEKRFLKD-SLYNEG 252
Cdd:cd23988    67 CAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSVVqrafggfrneSDREKFVHRlSMLNDS 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 253 ILivWDPSVYHSDIPKWYQNPDYNFFNN-------YKTYRKLHPNQPFYIlkpqmpwelwdilqeisPEEIQPNPPSSGM 325
Cdd:cd23988   147 VL--WIPAFMVKGGEKHVEWVNALILKNklkvrtaYPSLRLIHAVRGYWL-----------------TNKVNIKRPSTGL 207

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1222020091 326 LGIIIMMTLCDQVDIYEFLPSKRK---TDVCYYY-----QKFFDSA 363
Cdd:cd23988   208 LMYTLATRFCDEIHLYGFWPFPKDangNPVKYHYyddlkYRYFSNA 253
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 180-351 4.20e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 63.23  E-value: 4.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 180 PWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPT-ANFQQDVGTKTTIRLMNSQLVT------TEKR--FLKD-SLY 249
Cdd:cd23991    63 PYKQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTgGNISKDVGSKTNLVTANPSIISikyaklNERRkpFLETvSVY 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 250 NEGILIvwdpsvyhsdIPKWYQNPDYNF-FNNYKTYRKLHPNQPFYILKPQMpweLWDILQEISPEEIQPNPPSSGMLGI 328
Cdd:cd23991   143 GDAFLL----------LPAFSYRSNTALsFKVYYTLEDFKAKQKVIFFHPIY---LKHLAQFWRSKGVQVYRLSTGLMIT 209

                         170       180
                  ....*....|....*....|...
gi 1222020091 329 IIMMTLCDQVDIYEFLPSKRKTD 351
Cdd:cd23991   210 SAALELCEEVKLYGFWPFSKNTE 232
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 183-232 7.70e-11

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 62.20  E-value: 7.70e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1222020091 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLM 232
Cdd:cd23979    82 RCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFM 131
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 184-259 1.03e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 61.10  E-value: 1.03e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 184 CAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQ----LVTTEKRFLKDSlyNEGILIVWDP 259
Cdd:cd23975     4 CAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTsvplLLKNPDYFFKET--NETIYVIWGP 81
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 180-372 9.14e-10

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 59.07  E-value: 9.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 180 PWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAP-TANFQQDVGTKTTIRLMNSQLVttEKRFlkDSLYNEGILIVWD 258
Cdd:cd23989    62 PLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPlSREYTDDVGTKTQLVTANPSII--DKRF--QNLLWSRKSFVES 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 259 PSVY-HSDI--PKWYQNPDYN-FFNNYKTYRKLHPNQPFYILKPqmpwelwDILQEISP----EEIQPNPPSSGMLGIII 330
Cdd:cd23989   138 MKVYgRSYIymPAFSMKTGTDpSLRVYYTLADVGANQTVLFANP-------NFLRNVGKfwksKGVHAKRLSTGLFLVSA 210

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1222020091 331 MMTLCDQVDIYEFLPSKRKTDVCYYYQKFFDSACTMGAYHPL 372
Cdd:cd23989   211 ALGLCEEVTIYGFWPFSVDLDERTISHHYYDNVLPDSGFHAM 252
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 183-343 1.12e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 58.69  E-value: 1.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTAN-FQQDVGTKTTIRLMNSQLVTteKRFLKDSLYNEGILIVWdpSV 261
Cdd:cd23990    66 KCAVVGNGGILKNSKCGREIDSADFVFRCNLPPISEkYVRDVGVKTDVVTINPSIIT--ERFHKLEKWRRPFYEVL--QV 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1222020091 262 YHSD---IPKWY--QNPDYNF-----FNNYKTYRKLHPNQPFYILKPQMPWelwdilqeiSPEEIQPNPPSSGMLGIIIM 331
Cdd:cd23990   142 YENAsvvLPAFYntRNTDVSIrvkyvLDDFESQQAVYYFHPQYLLNVSRFW---------LRQGVRAKRISSGLMLVTAA 212

                         170
                  ....*....|..
gi 1222020091 332 MTLCDQVDIYEF 343
Cdd:cd23990   213 LELCEEVHLYGF 224
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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