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Conserved domains on  [gi|1217328637|ref|NP_001340557|]
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NEDD4-binding protein 2-like 1 isoform 6 [Homo sapiens]

Protein Classification

ATP-binding protein( domain architecture ID 1004283)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AAA_33 super family cl38431
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 165-222 1.70e-05

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


The actual alignment was detected with superfamily member pfam13671:

Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 43.45  E-value: 1.70e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1217328637 165 STDDFFFR----EDGAYEFNPDFLEEAHEWNQKRARKAMRNGIsPIIIDNTNLHAWEMKPYA 222
Cdd:pfam13671  29 SSDDERKRlfgeGRPSISYYTDATDRTYERLHELARIALRAGR-PVILDATNLRRDERARLL 89
COG4639 super family cl44097
Predicted kinase [General function prediction only];
41-60 5.59e-04

Predicted kinase [General function prediction only];


The actual alignment was detected with superfamily member COG4639:

Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 39.43  E-value: 5.59e-04
                          10        20
                  ....*....|....*....|
gi 1217328637  41 RKHLYLLRGLPGSGKTTLAR 60
Cdd:COG4639     1 MLSLVVLIGLPGSGKSTFAR 20
 
Name Accession Description Interval E-value
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 165-222 1.70e-05

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 43.45  E-value: 1.70e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1217328637 165 STDDFFFR----EDGAYEFNPDFLEEAHEWNQKRARKAMRNGIsPIIIDNTNLHAWEMKPYA 222
Cdd:pfam13671  29 SSDDERKRlfgeGRPSISYYTDATDRTYERLHELARIALRAGR-PVILDATNLRRDERARLL 89
COG4639 COG4639
Predicted kinase [General function prediction only];
41-60 5.59e-04

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 39.43  E-value: 5.59e-04
                          10        20
                  ....*....|....*....|
gi 1217328637  41 RKHLYLLRGLPGSGKTTLAR 60
Cdd:COG4639     1 MLSLVVLIGLPGSGKSTFAR 20
KaiC-like_N cd19488
N-terminal domain of KaiC family protein; uncharacterized subfamily; KaiC is a circadian clock ...
 41-59 1.16e-03

N-terminal domain of KaiC family protein; uncharacterized subfamily; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.


Pssm-ID: 410896 [Multi-domain]  Cd Length: 225  Bit Score: 39.25  E-value: 1.16e-03
                          10
                  ....*....|....*....
gi 1217328637  41 RKHLYLLRGLPGSGKTTLA 59
Cdd:cd19488    18 PRRLYLVEGAPGTGKTTLA 36
 
Name Accession Description Interval E-value
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 165-222 1.70e-05

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 43.45  E-value: 1.70e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1217328637 165 STDDFFFR----EDGAYEFNPDFLEEAHEWNQKRARKAMRNGIsPIIIDNTNLHAWEMKPYA 222
Cdd:pfam13671  29 SSDDERKRlfgeGRPSISYYTDATDRTYERLHELARIALRAGR-PVILDATNLRRDERARLL 89
COG4639 COG4639
Predicted kinase [General function prediction only];
41-60 5.59e-04

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 39.43  E-value: 5.59e-04
                          10        20
                  ....*....|....*....|
gi 1217328637  41 RKHLYLLRGLPGSGKTTLAR 60
Cdd:COG4639     1 MLSLVVLIGLPGSGKSTFAR 20
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
44-60 8.93e-04

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 39.13  E-value: 8.93e-04
                          10
                  ....*....|....*..
gi 1217328637  44 LYLLRGLPGSGKTTLAR 60
Cdd:COG0645     1 LILVCGLPGSGKSTLAR 17
KaiC-like_N cd19488
N-terminal domain of KaiC family protein; uncharacterized subfamily; KaiC is a circadian clock ...
 41-59 1.16e-03

N-terminal domain of KaiC family protein; uncharacterized subfamily; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.


Pssm-ID: 410896 [Multi-domain]  Cd Length: 225  Bit Score: 39.25  E-value: 1.16e-03
                          10
                  ....*....|....*....
gi 1217328637  41 RKHLYLLRGLPGSGKTTLA 59
Cdd:cd19488    18 PRRLYLVEGAPGTGKTTLA 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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