lysosomal cobalamin transporter ABCD4 isoform m [Homo sapiens]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| P-loop_NTPase super family | cl38936 | P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ... |
124-218 | 1.99e-35 | |||||
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families. The actual alignment was detected with superfamily member cd03223: Pssm-ID: 476819 [Multi-domain] Cd Length: 166 Bit Score: 125.73 E-value: 1.99e-35
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| YddA super family | cl34734 | ABC-type uncharacterized transport system, permease and ATPase components [General function ... |
1-239 | 2.02e-33 | |||||
ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; The actual alignment was detected with superfamily member COG4178: Pssm-ID: 443337 [Multi-domain] Cd Length: 571 Bit Score: 128.77 E-value: 2.02e-33
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| Name | Accession | Description | Interval | E-value | |||||
| ABCD_peroxisomal_ALDP | cd03223 | ATP-binding cassette domain of peroxisomal transporter, subfamily D; Peroxisomal ATP-binding ... |
124-218 | 1.99e-35 | |||||
ATP-binding cassette domain of peroxisomal transporter, subfamily D; Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed during fatty acid beta-oxidation. To communicate with the cytoplasm and mitochondria, peroxisomes need dedicated proteins to transport such hydrophilic molecules across their membranes. X-linked adrenoleukodystrophy (X-ALD) is caused by mutations in the ALD gene, which encodes ALDP (adrenoleukodystrophy protein ), a peroxisomal integral membrane protein that is a member of the ATP-binding cassette (ABC) transporter protein family. The disease is characterized by a striking and unpredictable variation in phenotypic expression. Phenotypes include the rapidly progressive childhood cerebral form (CCALD), the milder adult form, adrenomyeloneuropathy (AMN), and variants without neurologic involvement (i.e. asymptomatic). Pssm-ID: 213190 [Multi-domain] Cd Length: 166 Bit Score: 125.73 E-value: 1.99e-35
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| YddA | COG4178 | ABC-type uncharacterized transport system, permease and ATPase components [General function ... |
1-239 | 2.02e-33 | |||||
ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Pssm-ID: 443337 [Multi-domain] Cd Length: 571 Bit Score: 128.77 E-value: 2.02e-33
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| 3a01203 | TIGR00954 | Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein; [Transport and binding proteins, ... |
16-243 | 3.70e-26 | |||||
Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids] Pssm-ID: 273360 [Multi-domain] Cd Length: 659 Bit Score: 108.30 E-value: 3.70e-26
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| CcmA | COG4133 | ABC-type transport system involved in cytochrome c biogenesis, ATPase component ... |
137-239 | 2.05e-11 | |||||
ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 443308 [Multi-domain] Cd Length: 206 Bit Score: 62.11 E-value: 2.05e-11
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| ABC_tran | pfam00005 | ABC transporter; ABC transporters for a large family of proteins responsible for translocation ... |
141-266 | 9.47e-11 | |||||
ABC transporter; ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains. Pssm-ID: 394964 [Multi-domain] Cd Length: 150 Bit Score: 59.20 E-value: 9.47e-11
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| CFTR_protein | TIGR01271 | cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis ... |
139-215 | 1.71e-08 | |||||
cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis fibrosis transmembrane conductor regulator (CFTR) in eukaryotes. The principal role of this protein is chloride ion conductance. The protein is predicted to consist of 12 transmembrane domains. Mutations or lesions in the genetic loci have been linked to the aetiology of asthma, bronchiectasis, chronic obstructive pulmonary disease etc. Disease-causing mutations have been studied by 36Cl efflux assays in vitro cell cultures and electrophysiology, all of which point to the impairment of chloride channel stability and not the biosynthetic processing per se. [Transport and binding proteins, Anions] Pssm-ID: 273530 [Multi-domain] Cd Length: 1490 Bit Score: 55.69 E-value: 1.71e-08
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| PRK13539 | PRK13539 | cytochrome c biogenesis protein CcmA; Provisional |
137-182 | 2.96e-08 | |||||
cytochrome c biogenesis protein CcmA; Provisional Pssm-ID: 237421 [Multi-domain] Cd Length: 207 Bit Score: 52.95 E-value: 2.96e-08
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| PLN03232 | PLN03232 | ABC transporter C family member; Provisional |
22-213 | 3.42e-06 | |||||
ABC transporter C family member; Provisional Pssm-ID: 215640 [Multi-domain] Cd Length: 1495 Bit Score: 48.43 E-value: 3.42e-06
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| IS21_help_AAA | NF038214 | IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ... |
133-167 | 3.40e-03 | |||||
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements. Pssm-ID: 439516 Cd Length: 232 Bit Score: 38.22 E-value: 3.40e-03
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| Name | Accession | Description | Interval | E-value | |||||
| ABCD_peroxisomal_ALDP | cd03223 | ATP-binding cassette domain of peroxisomal transporter, subfamily D; Peroxisomal ATP-binding ... |
124-218 | 1.99e-35 | |||||
ATP-binding cassette domain of peroxisomal transporter, subfamily D; Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed during fatty acid beta-oxidation. To communicate with the cytoplasm and mitochondria, peroxisomes need dedicated proteins to transport such hydrophilic molecules across their membranes. X-linked adrenoleukodystrophy (X-ALD) is caused by mutations in the ALD gene, which encodes ALDP (adrenoleukodystrophy protein ), a peroxisomal integral membrane protein that is a member of the ATP-binding cassette (ABC) transporter protein family. The disease is characterized by a striking and unpredictable variation in phenotypic expression. Phenotypes include the rapidly progressive childhood cerebral form (CCALD), the milder adult form, adrenomyeloneuropathy (AMN), and variants without neurologic involvement (i.e. asymptomatic). Pssm-ID: 213190 [Multi-domain] Cd Length: 166 Bit Score: 125.73 E-value: 1.99e-35
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| YddA | COG4178 | ABC-type uncharacterized transport system, permease and ATPase components [General function ... |
1-239 | 2.02e-33 | |||||
ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Pssm-ID: 443337 [Multi-domain] Cd Length: 571 Bit Score: 128.77 E-value: 2.02e-33
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| 3a01203 | TIGR00954 | Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein; [Transport and binding proteins, ... |
16-243 | 3.70e-26 | |||||
Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids] Pssm-ID: 273360 [Multi-domain] Cd Length: 659 Bit Score: 108.30 E-value: 3.70e-26
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| SunT | COG2274 | ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase ... |
1-239 | 4.18e-17 | |||||
ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Pssm-ID: 441875 [Multi-domain] Cd Length: 711 Bit Score: 81.80 E-value: 4.18e-17
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| ABCC_bacteriocin_exporters | cd03245 | ATP-binding cassette domain of bacteriocin exporters, subfamily C; Many non-lantibiotic ... |
126-239 | 1.02e-15 | |||||
ATP-binding cassette domain of bacteriocin exporters, subfamily C; Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors which have N-terminal leader peptides that share similarities in amino acid sequence and contain a conserved processing site of two glycine residues in positions -1 and -2. A dedicated ATP-binding cassette (ABC) transporter is responsible for the proteolytic cleavage of the leader peptides and subsequent translocation of the bacteriocins across the cytoplasmic membrane. Pssm-ID: 213212 [Multi-domain] Cd Length: 220 Bit Score: 74.55 E-value: 1.02e-15
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| ABC_cobalt_CbiO_domain1 | cd03225 | First domain of the ATP-binding cassette component of cobalt transport system; Domain I of the ... |
126-239 | 1.88e-14 | |||||
First domain of the ATP-binding cassette component of cobalt transport system; Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems. Pssm-ID: 213192 [Multi-domain] Cd Length: 211 Bit Score: 70.96 E-value: 1.88e-14
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| ABCC_Protease_Secretion | cd03246 | ATP-binding cassette domain of PrtD, subfamily C; This family represents the ABC component of ... |
126-209 | 2.12e-14 | |||||
ATP-binding cassette domain of PrtD, subfamily C; This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export degradative enzymes by using a type I protein secretion system and lack an N-terminal signal peptide, but contain a C-terminal secretion signal. The Type I secretion apparatus is made up of three components, an ABC transporter, a membrane fusion protein (MFP), and an outer membrane protein (OMP). For the HlyA transporter complex, HlyB (ABC transporter) and HlyD (MFP) reside in the inner membrane of E. coli. The OMP component is TolC, which is thought to interact with the MFP to form a continuous channel across the periplasm from the cytoplasm to the exterior. HlyB belongs to the family of ABC transporters, which are ubiquitous, ATP-dependent transmembrane pumps or channels. The spectrum of transport substrates ranges from inorganic ions, nutrients such as amino acids, sugars, or peptides, hydrophobic drugs, to large polypeptides, such as HlyA. Pssm-ID: 213213 [Multi-domain] Cd Length: 173 Bit Score: 69.94 E-value: 2.12e-14
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| MdlB | COG1132 | ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]; |
1-239 | 1.90e-12 | |||||
ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]; Pssm-ID: 440747 [Multi-domain] Cd Length: 579 Bit Score: 67.50 E-value: 1.90e-12
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| ABCC_cytochrome_bd | cd03247 | ATP-binding cassette domain of CydCD, subfamily C; The CYD subfamily implicated in cytochrome ... |
129-211 | 5.37e-12 | |||||
ATP-binding cassette domain of CydCD, subfamily C; The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd quinol oxidase and for periplasmic c-type cytochromes. CydCD were proposed to determine a heterooligomeric complex important for heme export into the periplasm or to be involved in the maintenance of the proper redox state of the periplasmic space. In Bacillus subtilis, the absence of CydCD does not affect the presence of halo-cytochrome c in the membrane and this observation suggests that CydCD proteins are not involved in the export of heme in this organism. Pssm-ID: 213214 [Multi-domain] Cd Length: 178 Bit Score: 63.10 E-value: 5.37e-12
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| ABC_Org_Solvent_Resistant | cd03261 | ATP-binding cassette transport system involved in resistance to organic solvents; ABC ... |
137-239 | 1.88e-11 | |||||
ATP-binding cassette transport system involved in resistance to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213228 [Multi-domain] Cd Length: 235 Bit Score: 62.90 E-value: 1.88e-11
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| CcmA | COG4133 | ABC-type transport system involved in cytochrome c biogenesis, ATPase component ... |
137-239 | 2.05e-11 | |||||
ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 443308 [Multi-domain] Cd Length: 206 Bit Score: 62.11 E-value: 2.05e-11
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| ABC_ATPase | cd00267 | ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ... |
126-213 | 3.22e-11 | |||||
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213179 [Multi-domain] Cd Length: 157 Bit Score: 60.72 E-value: 3.22e-11
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| ABC_tran | pfam00005 | ABC transporter; ABC transporters for a large family of proteins responsible for translocation ... |
141-266 | 9.47e-11 | |||||
ABC transporter; ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains. Pssm-ID: 394964 [Multi-domain] Cd Length: 150 Bit Score: 59.20 E-value: 9.47e-11
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| MlaF | COG1127 | ATPase subunit MlaF of the ABC-type intermembrane phospholipid transporter Mla [Cell wall ... |
137-239 | 8.04e-10 | |||||
ATPase subunit MlaF of the ABC-type intermembrane phospholipid transporter Mla [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 440744 [Multi-domain] Cd Length: 241 Bit Score: 58.07 E-value: 8.04e-10
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| ABCC_MRP_domain1 | cd03250 | ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; This ... |
132-212 | 1.00e-09 | |||||
ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; This subfamily is also known as MRP (multidrug resistance-associated protein). Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resisting lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions, such as glutathione, glucuronate, and sulfate. Pssm-ID: 213217 [Multi-domain] Cd Length: 204 Bit Score: 57.09 E-value: 1.00e-09
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| Uup | COG0488 | ATPase components of ABC transporters with duplicated ATPase domains [General function ... |
126-219 | 1.24e-09 | |||||
ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Pssm-ID: 440254 [Multi-domain] Cd Length: 520 Bit Score: 58.92 E-value: 1.24e-09
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| ABC_NrtD_SsuB_transporters | cd03293 | ATP-binding cassette domain of the nitrate and sulfonate transporters; NrtD and SsuB are the ... |
126-239 | 3.61e-09 | |||||
ATP-binding cassette domain of the nitrate and sulfonate transporters; NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213260 [Multi-domain] Cd Length: 220 Bit Score: 55.94 E-value: 3.61e-09
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| ABCC_MRP_domain2 | cd03244 | ATP-binding cassette domain 2 of multidrug resistance-associated protein; The ABC subfamily C ... |
127-239 | 3.66e-09 | |||||
ATP-binding cassette domain 2 of multidrug resistance-associated protein; The ABC subfamily C is also known as MRP (multidrug resistance-associated protein). Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resistance lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions, such as glutathione, glucuronate, and sulfate. Pssm-ID: 213211 [Multi-domain] Cd Length: 221 Bit Score: 55.96 E-value: 3.66e-09
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| ABC_MJ0796_LolCDE_FtsE | cd03255 | ATP-binding cassette domain of the transporters involved in export of lipoprotein and ... |
138-239 | 1.11e-08 | |||||
ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and Cell division ATP-binding protein FtsE; This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. The FtsEX complex resembles an ABC transporter, where FtsE is the ATPase and the membrane subunit FtsX resembles a permease subunit. But rather than transporting any substrate, the complex acts in cell division by undergoing conformational changes that alter the activity of cell wall hydrolases located outside the plasma membrane. The complex is widely conserved in bacteria, but also extremely divergent in sequence between different lineages. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane. Pssm-ID: 213222 [Multi-domain] Cd Length: 218 Bit Score: 54.42 E-value: 1.11e-08
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| CFTR_protein | TIGR01271 | cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis ... |
139-215 | 1.71e-08 | |||||
cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis fibrosis transmembrane conductor regulator (CFTR) in eukaryotes. The principal role of this protein is chloride ion conductance. The protein is predicted to consist of 12 transmembrane domains. Mutations or lesions in the genetic loci have been linked to the aetiology of asthma, bronchiectasis, chronic obstructive pulmonary disease etc. Disease-causing mutations have been studied by 36Cl efflux assays in vitro cell cultures and electrophysiology, all of which point to the impairment of chloride channel stability and not the biosynthetic processing per se. [Transport and binding proteins, Anions] Pssm-ID: 273530 [Multi-domain] Cd Length: 1490 Bit Score: 55.69 E-value: 1.71e-08
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| PRK13539 | PRK13539 | cytochrome c biogenesis protein CcmA; Provisional |
137-182 | 2.96e-08 | |||||
cytochrome c biogenesis protein CcmA; Provisional Pssm-ID: 237421 [Multi-domain] Cd Length: 207 Bit Score: 52.95 E-value: 2.96e-08
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| ABCC_CFTR1 | cd03291 | ATP-binding cassette domain of the cystic fibrosis transmembrane regulator, subfamily C; The ... |
139-213 | 7.14e-08 | |||||
ATP-binding cassette domain of the cystic fibrosis transmembrane regulator, subfamily C; The CFTR subfamily domain 1. The cystic fibrosis transmembrane regulator (CFTR), the product of the gene mutated in patients with cystic fibrosis, has adapted the ABC transporter structural motif to form a tightly regulated anion channel at the apical surface of many epithelia. Use of the term assembly of a functional ion channel implies the coming together of subunits, or at least smaller not-yet functional components of the active whole. In fact, on the basis of current knowledge only the CFTR polypeptide itself is required to form an ATP- and protein kinase A-dependent low-conductance chloride channel of the type present in the apical membrane of many epithelial cells. CFTR displays the typical organization (IM-ABC)2 and carries a characteristic hydrophilic R-domain that separates IM1-ABC1 from IM2-ABC2. Pssm-ID: 213258 [Multi-domain] Cd Length: 282 Bit Score: 52.94 E-value: 7.14e-08
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| ABC_Carb_Solutes_like | cd03259 | ATP-binding cassette domain of the carbohydrate and solute transporters-like; This family is ... |
137-239 | 1.46e-07 | |||||
ATP-binding cassette domain of the carbohydrate and solute transporters-like; This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213226 [Multi-domain] Cd Length: 213 Bit Score: 50.98 E-value: 1.46e-07
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| ABC_MetN_methionine_transporter | cd03258 | ATP-binding cassette domain of methionine transporter; MetN (also known as YusC) is an ... |
126-239 | 2.48e-07 | |||||
ATP-binding cassette domain of methionine transporter; MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213225 [Multi-domain] Cd Length: 233 Bit Score: 50.66 E-value: 2.48e-07
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| PRK13538 | PRK13538 | cytochrome c biogenesis heme-transporting ATPase CcmA; |
137-182 | 2.82e-07 | |||||
cytochrome c biogenesis heme-transporting ATPase CcmA; Pssm-ID: 184125 [Multi-domain] Cd Length: 204 Bit Score: 50.19 E-value: 2.82e-07
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| GsiA | COG1123 | ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain ... |
108-239 | 2.94e-07 | |||||
ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 440740 [Multi-domain] Cd Length: 514 Bit Score: 51.44 E-value: 2.94e-07
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| ABC_Metallic_Cations | cd03235 | ATP-binding cassette domain of the metal-type transporters; This family includes transporters ... |
136-199 | 6.19e-07 | |||||
ATP-binding cassette domain of the metal-type transporters; This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-siderophore uptake family suggesting that they share a common ancestor. The best characterized metal-type ABC transporters are the YfeABCD system of Y. pestis, the SitABCD system of Salmonella enterica serovar Typhimurium, and the SitABCD transporter of Shigella flexneri. Moreover other uncharacterized homologs of these metal-type transporters are mainly found in pathogens like Haemophilus or enteroinvasive E. coli isolates. Pssm-ID: 213202 [Multi-domain] Cd Length: 213 Bit Score: 49.07 E-value: 6.19e-07
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| ABC_PhnC_transporter | cd03256 | ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; ... |
126-182 | 6.59e-07 | |||||
ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all kingdoms of wildlife, but only prokaryotic microorganisms are able to cleave this bond. Certain bacteria such as E. coli can use alkylphosphonates as a phosphorus source. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213223 [Multi-domain] Cd Length: 241 Bit Score: 49.49 E-value: 6.59e-07
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| cbiO | PRK13632 | cobalt transporter ATP-binding subunit; Provisional |
121-183 | 7.66e-07 | |||||
cobalt transporter ATP-binding subunit; Provisional Pssm-ID: 237452 [Multi-domain] Cd Length: 271 Bit Score: 49.60 E-value: 7.66e-07
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| potA | PRK09452 | spermidine/putrescine ABC transporter ATP-binding protein PotA; |
117-184 | 8.73e-07 | |||||
spermidine/putrescine ABC transporter ATP-binding protein PotA; Pssm-ID: 236523 [Multi-domain] Cd Length: 375 Bit Score: 49.95 E-value: 8.73e-07
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| PRK11160 | PRK11160 | cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed |
112-239 | 9.55e-07 | |||||
cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed Pssm-ID: 236865 [Multi-domain] Cd Length: 574 Bit Score: 50.21 E-value: 9.55e-07
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| ABC_Class3 | cd03229 | ATP-binding cassette domain of the binding protein-dependent transport systems; This class is ... |
137-215 | 9.74e-07 | |||||
ATP-binding cassette domain of the binding protein-dependent transport systems; This class is comprised of all BPD (Binding Protein Dependent) systems that are largely represented in archaea and eubacteria and are primarily involved in scavenging solutes from the environment. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213196 [Multi-domain] Cd Length: 178 Bit Score: 47.95 E-value: 9.74e-07
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| ABC_PstB_phosphate_transporter | cd03260 | ATP-binding cassette domain of the phosphate transport system; Phosphate uptake is of ... |
137-239 | 2.05e-06 | |||||
ATP-binding cassette domain of the phosphate transport system; Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein is a phosphate-binding protein located in the periplasmic space. PstA and PstC are hydrophobic and they form the transmembrane portion of the Pst system. PstB is the catalytic subunit, which couples the energy of ATP hydrolysis to the import of phosphate across cellular membranes through the Pst system, often referred as ABC-protein. PstB belongs to one of the largest superfamilies of proteins characterized by a highly conserved adenosine triphosphate (ATP) binding cassette (ABC), which is also a nucleotide binding domain (NBD). Pssm-ID: 213227 [Multi-domain] Cd Length: 227 Bit Score: 47.95 E-value: 2.05e-06
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| GsiA | COG1123 | ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain ... |
126-250 | 2.05e-06 | |||||
ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 440740 [Multi-domain] Cd Length: 514 Bit Score: 48.75 E-value: 2.05e-06
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| PLN03232 | PLN03232 | ABC transporter C family member; Provisional |
22-213 | 3.42e-06 | |||||
ABC transporter C family member; Provisional Pssm-ID: 215640 [Multi-domain] Cd Length: 1495 Bit Score: 48.43 E-value: 3.42e-06
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| PRK13543 | PRK13543 | heme ABC exporter ATP-binding protein CcmA; |
119-184 | 4.40e-06 | |||||
heme ABC exporter ATP-binding protein CcmA; Pssm-ID: 184129 [Multi-domain] Cd Length: 214 Bit Score: 46.77 E-value: 4.40e-06
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| PRK10575 | PRK10575 | Fe3+-hydroxamate ABC transporter ATP-binding protein FhuC; |
121-239 | 4.73e-06 | |||||
Fe3+-hydroxamate ABC transporter ATP-binding protein FhuC; Pssm-ID: 182561 [Multi-domain] Cd Length: 265 Bit Score: 47.09 E-value: 4.73e-06
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| ABC_MalK_N | cd03301 | The N-terminal ATPase domain of the maltose transporter, MalK; ATP binding cassette (ABC) ... |
137-182 | 6.85e-06 | |||||
The N-terminal ATPase domain of the maltose transporter, MalK; ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two transmembrane-spanning domains (TMDs) or subunits and two nucleotide binding domains (NBDs) or subunits that couple transport to the hydrolysis of ATP. In the maltose transport system, the periplasmic maltose binding protein (MBP) stimulates the ATPase activity of the membrane-associated transporter, which consists of two transmembrane subunits, MalF and MalG, and two copies of the ATP binding subunit, MalK, and becomes tightly bound to the transporter in the catalytic transition state, ensuring that maltose is passed to the transporter as ATP is hydrolyzed. Pssm-ID: 213268 [Multi-domain] Cd Length: 213 Bit Score: 46.09 E-value: 6.85e-06
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| ABC_PotA_N | cd03300 | ATP-binding cassette domain of the polyamine transporter; PotA is an ABC-type transporter and ... |
137-250 | 7.50e-06 | |||||
ATP-binding cassette domain of the polyamine transporter; PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required for homodimerization with PotA and heterdimerization with PotB. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213267 [Multi-domain] Cd Length: 232 Bit Score: 46.08 E-value: 7.50e-06
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| MK0520 | COG2401 | ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction ... |
138-241 | 1.13e-05 | |||||
ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction only]; Pssm-ID: 441957 [Multi-domain] Cd Length: 222 Bit Score: 45.72 E-value: 1.13e-05
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| ABC_TM1139_LivF_branched | cd03224 | ATP-binding cassette domain of branched-chain amino acid transporter; LivF (TM1139) is part of ... |
141-198 | 1.18e-05 | |||||
ATP-binding cassette domain of branched-chain amino acid transporter; LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ). ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. Pssm-ID: 213191 [Multi-domain] Cd Length: 222 Bit Score: 45.50 E-value: 1.18e-05
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| ABC_drug_resistance_like | cd03264 | ABC-type multidrug transport system, ATPase component; The biological function of this family ... |
126-239 | 1.35e-05 | |||||
ABC-type multidrug transport system, ATPase component; The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213231 [Multi-domain] Cd Length: 211 Bit Score: 45.26 E-value: 1.35e-05
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| lolD | PRK11629 | lipoprotein-releasing ABC transporter ATP-binding protein LolD; |
140-182 | 1.49e-05 | |||||
lipoprotein-releasing ABC transporter ATP-binding protein LolD; Pssm-ID: 183244 [Multi-domain] Cd Length: 233 Bit Score: 45.19 E-value: 1.49e-05
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| ABC_KpsT_Wzt | cd03220 | ATP-binding cassette component of polysaccharide transport system; The KpsT/Wzt ABC ... |
137-183 | 1.55e-05 | |||||
ATP-binding cassette component of polysaccharide transport system; The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and teichoic acids have been shown to be exported by ABC transporters. A typical system is made of a conserved integral membrane and an ABC. In addition to these proteins, capsular polysaccharide exporter systems require two 'accessory' proteins to perform their function: a periplasmic (E.coli) or a lipid-anchored outer membrane protein called OMA (Neisseria meningitidis and Haemophilus influenza) and a cytoplasmic membrane protein MPA2. Pssm-ID: 213187 [Multi-domain] Cd Length: 224 Bit Score: 45.22 E-value: 1.55e-05
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| Uup | COG0488 | ATPase components of ABC transporters with duplicated ATPase domains [General function ... |
115-182 | 2.05e-05 | |||||
ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Pssm-ID: 440254 [Multi-domain] Cd Length: 520 Bit Score: 45.83 E-value: 2.05e-05
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| TagH | COG1134 | ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate ... |
142-183 | 2.12e-05 | |||||
ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism]; Pssm-ID: 440749 [Multi-domain] Cd Length: 245 Bit Score: 45.07 E-value: 2.12e-05
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| PRK11831 | PRK11831 | phospholipid ABC transporter ATP-binding protein MlaF; |
122-217 | 2.25e-05 | |||||
phospholipid ABC transporter ATP-binding protein MlaF; Pssm-ID: 236997 [Multi-domain] Cd Length: 269 Bit Score: 45.14 E-value: 2.25e-05
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| ccmA | TIGR01189 | heme ABC exporter, ATP-binding protein CcmA; This model describes the cyt c biogenesis protein ... |
126-184 | 3.62e-05 | |||||
heme ABC exporter, ATP-binding protein CcmA; This model describes the cyt c biogenesis protein encoded by ccmA in bacteria. An exception is, an arabidopsis protein. Quite likely this is encoded by an organelle. Bacterial c-type cytocromes are located on the periplasmic side of the cytoplasmic membrane. Several gene products encoded in a locus designated as 'ccm' are implicated in the transport and assembly of the functional cytochrome C. This cluster includes genes: ccmA;B;C;D;E;F;G and H. The posttranslational pathway includes the transport of heme moiety, the secretion of the apoprotein and the covalent attachment of the heme with the apoprotein. The proteins ccmA and B represent an ABC transporter; ccmC and D participate in heme transfer to ccmE, which function as a periplasmic heme chaperone. The presence of ccmF, G and H is suggested to be obligatory for the final functional assembly of cytochrome c. [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Other] Pssm-ID: 273491 [Multi-domain] Cd Length: 198 Bit Score: 43.89 E-value: 3.62e-05
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| ABC_CcmA_heme_exporter | cd03231 | Cytochrome c biogenesis ATP-binding export protein; CcmA, the ATP-binding component of the ... |
140-184 | 4.53e-05 | |||||
Cytochrome c biogenesis ATP-binding export protein; CcmA, the ATP-binding component of the bacterial CcmAB transporter. The CCM family is involved in bacterial cytochrome c biogenesis. Cytochrome c maturation in E. coli requires the ccm operon, which encodes eight membrane proteins (CcmABCDEFGH). CcmE is a periplasmic heme chaperon that binds heme covalently and transfers it onto apocytochrome c in the presence of CcmF, CcmG, and CcmH. The CcmAB proteins represent an ABC transporter and the CcmCD proteins participate in heme transfer to CcmE. Pssm-ID: 213198 [Multi-domain] Cd Length: 201 Bit Score: 43.64 E-value: 4.53e-05
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| ABCG_White | cd03234 | White pigment protein homolog of ABCG transporter subfamily; The White subfamily represents ... |
126-244 | 6.62e-05 | |||||
White pigment protein homolog of ABCG transporter subfamily; The White subfamily represents ABC transporters homologous to the Drosophila white gene, which acts as a dimeric importer for eye pigment precursors. The eye pigmentation of Drosophila is developed from the synthesis and deposition in the cells of red pigments, which are synthesized from guanine, and brown pigments, which are synthesized from tryptophan. The pigment precursors are encoded by the white, brown, and scarlet genes, respectively. Evidence from genetic and biochemical studies suggest that the White and Brown proteins function as heterodimers to import guanine, while the White and Scarlet proteins function to import tryptophan. However, a recent study also suggests that White may be involved in the transport of a metabolite, such as 3-hydroxykynurenine, across intracellular membranes. Mammalian ABC transporters belonging to the White subfamily (ABCG1, ABCG5, and ABCG8) have been shown to be involved in the regulation of lipid-trafficking mechanisms in macrophages, hepatocytes, and intestinal mucosa cells. ABCG1 (ABC8), the human homolog of the Drosophila white gene is induced in monocyte-derived macrophages during cholesterol influx mediated by acetylated low-density lipoprotein. It is possible that human ABCG1 forms heterodimers with several heterologous partners. Pssm-ID: 213201 [Multi-domain] Cd Length: 226 Bit Score: 43.41 E-value: 6.62e-05
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| PotA | COG3842 | ABC-type Fe3+/spermidine/putrescine transport systems, ATPase component [Amino acid transport ... |
137-182 | 6.64e-05 | |||||
ABC-type Fe3+/spermidine/putrescine transport systems, ATPase component [Amino acid transport and metabolism]; Pssm-ID: 443052 [Multi-domain] Cd Length: 353 Bit Score: 43.93 E-value: 6.64e-05
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| PRK15064 | PRK15064 | ABC transporter ATP-binding protein; Provisional |
137-183 | 6.82e-05 | |||||
ABC transporter ATP-binding protein; Provisional Pssm-ID: 237894 [Multi-domain] Cd Length: 530 Bit Score: 44.11 E-value: 6.82e-05
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| MRP_assoc_pro | TIGR00957 | multi drug resistance-associated protein (MRP); This model describes multi drug ... |
140-248 | 7.49e-05 | |||||
multi drug resistance-associated protein (MRP); This model describes multi drug resistance-associated protein (MRP) in eukaryotes. The multidrug resistance-associated protein is an integral membrane protein that causes multidrug resistance when overexpressed in mammalian cells. It belongs to ABC transporter superfamily. The protein topology and function was experimentally demonstrated by epitope tagging and immunofluorescence. Insertion of tags in the critical regions associated with drug efflux, abrogated its function. The C-terminal domain seem to highly conserved. [Transport and binding proteins, Other] Pssm-ID: 188098 [Multi-domain] Cd Length: 1522 Bit Score: 44.55 E-value: 7.49e-05
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| ssuB | PRK11247 | aliphatic sulfonates transport ATP-binding subunit; Provisional |
115-180 | 7.73e-05 | |||||
aliphatic sulfonates transport ATP-binding subunit; Provisional Pssm-ID: 183055 [Multi-domain] Cd Length: 257 Bit Score: 43.51 E-value: 7.73e-05
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| cbiO | PRK13640 | energy-coupling factor transporter ATPase; |
119-174 | 7.82e-05 | |||||
energy-coupling factor transporter ATPase; Pssm-ID: 184200 [Multi-domain] Cd Length: 282 Bit Score: 43.64 E-value: 7.82e-05
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| fecE | PRK11231 | Fe(3+) dicitrate ABC transporter ATP-binding protein FecE; |
137-213 | 7.99e-05 | |||||
Fe(3+) dicitrate ABC transporter ATP-binding protein FecE; Pssm-ID: 183044 [Multi-domain] Cd Length: 255 Bit Score: 43.46 E-value: 7.99e-05
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| tauB | PRK11248 | taurine ABC transporter ATP-binding subunit; |
125-184 | 9.30e-05 | |||||
taurine ABC transporter ATP-binding subunit; Pssm-ID: 183056 [Multi-domain] Cd Length: 255 Bit Score: 43.15 E-value: 9.30e-05
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| PLN03130 | PLN03130 | ABC transporter C family member; Provisional |
2-213 | 9.51e-05 | |||||
ABC transporter C family member; Provisional Pssm-ID: 215595 [Multi-domain] Cd Length: 1622 Bit Score: 43.96 E-value: 9.51e-05
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| ABC_putative_ATPase | cd03269 | ATP-binding cassette domain of an uncharacterized transporter; This subgroup is related to the ... |
137-238 | 9.89e-05 | |||||
ATP-binding cassette domain of an uncharacterized transporter; This subgroup is related to the subfamily A transporters involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity. In eubacteria and archaea, the typical organization consists of one ABC and one or two integral membranes. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region in addition to the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213236 [Multi-domain] Cd Length: 210 Bit Score: 42.65 E-value: 9.89e-05
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| MRP_assoc_pro | TIGR00957 | multi drug resistance-associated protein (MRP); This model describes multi drug ... |
136-219 | 1.00e-04 | |||||
multi drug resistance-associated protein (MRP); This model describes multi drug resistance-associated protein (MRP) in eukaryotes. The multidrug resistance-associated protein is an integral membrane protein that causes multidrug resistance when overexpressed in mammalian cells. It belongs to ABC transporter superfamily. The protein topology and function was experimentally demonstrated by epitope tagging and immunofluorescence. Insertion of tags in the critical regions associated with drug efflux, abrogated its function. The C-terminal domain seem to highly conserved. [Transport and binding proteins, Other] Pssm-ID: 188098 [Multi-domain] Cd Length: 1522 Bit Score: 44.17 E-value: 1.00e-04
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| ABC_Iron-Siderophores_B12_Hemin | cd03214 | ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related ... |
126-182 | 1.03e-04 | |||||
ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC transporter mediating vitamin B12 uptake. The two ATP-binding cassettes (BtuD) are in close contact with each other, as are the two membrane-spanning subunits (BtuC); this arrangement is distinct from that observed for the E. coli lipid flippase MsbA. The BtuC subunits provide 20 transmembrane helices grouped around a translocation pathway that is closed to the cytoplasm by a gate region, whereas the dimer arrangement of the BtuD subunits resembles the ATP-bound form of the Rad50 DNA repair enzyme. A prominent cytoplasmic loop of BtuC forms the contact region with the ATP-binding cassette and represent a conserved motif among the ABC transporters. Pssm-ID: 213181 [Multi-domain] Cd Length: 180 Bit Score: 42.04 E-value: 1.03e-04
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| 3a01208 | TIGR00958 | Conjugate Transporter-2 (CT2) Family protein; [Transport and binding proteins, Other] |
129-216 | 1.14e-04 | |||||
Conjugate Transporter-2 (CT2) Family protein; [Transport and binding proteins, Other] Pssm-ID: 273363 [Multi-domain] Cd Length: 711 Bit Score: 43.56 E-value: 1.14e-04
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| PRK13540 | PRK13540 | cytochrome c biogenesis protein CcmA; Provisional |
125-183 | 2.18e-04 | |||||
cytochrome c biogenesis protein CcmA; Provisional Pssm-ID: 184127 [Multi-domain] Cd Length: 200 Bit Score: 41.47 E-value: 2.18e-04
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| ABC_CysA_sulfate_importer | cd03296 | ATP-binding cassette domain of the sulfate transporter; Part of the ABC transporter complex ... |
139-182 | 2.34e-04 | |||||
ATP-binding cassette domain of the sulfate transporter; Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a solute-binding protein (cysP). ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213263 [Multi-domain] Cd Length: 239 Bit Score: 41.94 E-value: 2.34e-04
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| NupO | COG3845 | ABC-type guanosine uptake system NupNOPQ, ATPase component NupO [Nucleotide transport and ... |
115-197 | 2.93e-04 | |||||
ABC-type guanosine uptake system NupNOPQ, ATPase component NupO [Nucleotide transport and metabolism]; Pssm-ID: 443055 [Multi-domain] Cd Length: 504 Bit Score: 42.32 E-value: 2.93e-04
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| PRK10070 | PRK10070 | proline/glycine betaine ABC transporter ATP-binding protein ProV; |
141-182 | 3.78e-04 | |||||
proline/glycine betaine ABC transporter ATP-binding protein ProV; Pssm-ID: 182221 [Multi-domain] Cd Length: 400 Bit Score: 41.94 E-value: 3.78e-04
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| hmuV | PRK13548 | hemin importer ATP-binding subunit; Provisional |
138-239 | 3.82e-04 | |||||
hemin importer ATP-binding subunit; Provisional Pssm-ID: 237422 [Multi-domain] Cd Length: 258 Bit Score: 41.30 E-value: 3.82e-04
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| ABCC_SUR1_N | cd03290 | ATP-binding cassette domain of the sulfonylurea receptor, subfamily C; The SUR domain 1. The ... |
135-213 | 4.01e-04 | |||||
ATP-binding cassette domain of the sulfonylurea receptor, subfamily C; The SUR domain 1. The sulfonylurea receptor SUR is an ATP transporter of the ABCC/MRP family with tandem ATPase binding domains. Unlike other ABC proteins, it has no intrinsic transport function, neither active nor passive, but associates with the potassium channel proteins Kir6.1 or Kir6.2 to form the ATP-sensitive potassium (K(ATP)) channel. Within the channel complex, SUR serves as a regulatory subunit that fine-tunes the gating of Kir6.x in response to alterations in cellular metabolism. It constitutes a major pharmaceutical target as it binds numerous drugs, K(ATP) channel openers and blockers, capable of up- or down-regulating channel activity. Pssm-ID: 213257 [Multi-domain] Cd Length: 218 Bit Score: 40.78 E-value: 4.01e-04
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| CFTR_protein | TIGR01271 | cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis ... |
135-241 | 5.34e-04 | |||||
cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis fibrosis transmembrane conductor regulator (CFTR) in eukaryotes. The principal role of this protein is chloride ion conductance. The protein is predicted to consist of 12 transmembrane domains. Mutations or lesions in the genetic loci have been linked to the aetiology of asthma, bronchiectasis, chronic obstructive pulmonary disease etc. Disease-causing mutations have been studied by 36Cl efflux assays in vitro cell cultures and electrophysiology, all of which point to the impairment of chloride channel stability and not the biosynthetic processing per se. [Transport and binding proteins, Anions] Pssm-ID: 273530 [Multi-domain] Cd Length: 1490 Bit Score: 41.82 E-value: 5.34e-04
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| met_CoM_red_A2 | TIGR03269 | methyl coenzyme M reductase system, component A2; The enzyme that catalyzes the final step in ... |
137-174 | 5.62e-04 | |||||
methyl coenzyme M reductase system, component A2; The enzyme that catalyzes the final step in methanogenesis, methyl coenzyme M reductase, contains alpha, beta, and gamma chains. In older literature, the complex of alpha, beta, and gamma chains was termed component C, while this single chain protein was termed methyl coenzyme M reductase system component A2. [Energy metabolism, Methanogenesis] Pssm-ID: 132313 [Multi-domain] Cd Length: 520 Bit Score: 41.33 E-value: 5.62e-04
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| PRK10247 | PRK10247 | putative ABC transporter ATP-binding protein YbbL; Provisional |
125-239 | 5.64e-04 | |||||
putative ABC transporter ATP-binding protein YbbL; Provisional Pssm-ID: 182331 [Multi-domain] Cd Length: 225 Bit Score: 40.47 E-value: 5.64e-04
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| PRK11174 | PRK11174 | cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed |
137-239 | 6.33e-04 | |||||
cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed Pssm-ID: 236870 [Multi-domain] Cd Length: 588 Bit Score: 41.37 E-value: 6.33e-04
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| ABCG_PDR_domain1 | cd03233 | First domain of the pleiotropic drug resistance-like subfamily G of ATP-binding cassette ... |
136-182 | 8.00e-04 | |||||
First domain of the pleiotropic drug resistance-like subfamily G of ATP-binding cassette transporters; The pleiotropic drug resistance (PDR) is a well-described phenomenon occurring in fungi and shares several similarities with processes in bacteria and higher eukaryotes. This PDR subfamily represents domain I of its (ABC-IM)2 organization. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213200 [Multi-domain] Cd Length: 202 Bit Score: 39.94 E-value: 8.00e-04
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| PRK10535 | PRK10535 | macrolide ABC transporter ATP-binding protein/permease MacB; |
122-181 | 1.04e-03 | |||||
macrolide ABC transporter ATP-binding protein/permease MacB; Pssm-ID: 182528 [Multi-domain] Cd Length: 648 Bit Score: 40.48 E-value: 1.04e-03
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| MalK | COG3839 | ABC-type sugar transport system, ATPase component MalK [Carbohydrate transport and metabolism]; ... |
141-182 | 1.09e-03 | |||||
ABC-type sugar transport system, ATPase component MalK [Carbohydrate transport and metabolism]; Pssm-ID: 443050 [Multi-domain] Cd Length: 352 Bit Score: 40.06 E-value: 1.09e-03
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| PTZ00243 | PTZ00243 | ABC transporter; Provisional |
138-213 | 1.12e-03 | |||||
ABC transporter; Provisional Pssm-ID: 240327 [Multi-domain] Cd Length: 1560 Bit Score: 40.53 E-value: 1.12e-03
|
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| PLN03130 | PLN03130 | ABC transporter C family member; Provisional |
111-208 | 1.13e-03 | |||||
ABC transporter C family member; Provisional Pssm-ID: 215595 [Multi-domain] Cd Length: 1622 Bit Score: 40.88 E-value: 1.13e-03
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| PRK10789 | PRK10789 | SmdA family multidrug ABC transporter permease/ATP-binding protein; |
115-171 | 1.29e-03 | |||||
SmdA family multidrug ABC transporter permease/ATP-binding protein; Pssm-ID: 182732 [Multi-domain] Cd Length: 569 Bit Score: 40.08 E-value: 1.29e-03
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| cbiO | PRK13634 | cobalt transporter ATP-binding subunit; Provisional |
141-184 | 1.32e-03 | |||||
cobalt transporter ATP-binding subunit; Provisional Pssm-ID: 237454 [Multi-domain] Cd Length: 290 Bit Score: 39.62 E-value: 1.32e-03
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| ABCC_NFT1 | cd03369 | ATP-binding cassette domain 2 of NFT1, subfamily C; Domain 2 of NFT1 (New full-length MRP-type ... |
119-244 | 1.47e-03 | |||||
ATP-binding cassette domain 2 of NFT1, subfamily C; Domain 2 of NFT1 (New full-length MRP-type transporter 1). NFT1 belongs to the MRP (multidrug resistance-associated protein) family of ABC transporters. Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resisting lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions such as glutathione, glucuronate, and sulfate. Pssm-ID: 213269 [Multi-domain] Cd Length: 207 Bit Score: 39.32 E-value: 1.47e-03
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| ABC_Mj1267_LivG_branched | cd03219 | ATP-binding cassette component of branched chain amino acids transport system; The Mj1267/LivG ... |
141-257 | 1.49e-03 | |||||
ATP-binding cassette component of branched chain amino acids transport system; The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E. coli branched-chain amino acid transporter. MJ1267 contains an insertion from residues 114 to 123 characteristic of LivG (Leucine-Isoleucine-Valine) homologs. The branched-chain amino acid transporter from E. coli comprises a heterodimer of ABCs (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ). Pssm-ID: 213186 [Multi-domain] Cd Length: 236 Bit Score: 39.34 E-value: 1.49e-03
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| ABC_HisP_GlnQ | cd03262 | ATP-binding cassette domain of the histidine and glutamine transporters; HisP and GlnQ are the ... |
137-182 | 1.57e-03 | |||||
ATP-binding cassette domain of the histidine and glutamine transporters; HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, respectively. Histidine permease is a multi-subunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP has properties intermediate between those of integral and peripheral membrane proteins and is accessible from both sides of the membrane, presumably by its interaction with HisQ and HisM. The two HisP subunits form a homodimer within the complex. The domain structure of the amino acid uptake systems is typical for prokaryotic extracellular solute binding protein-dependent uptake systems. All of the amino acid uptake systems also have at least one, and in a few cases, two extracellular solute binding proteins located in the periplasm of Gram-negative bacteria, or attached to the cell membrane of Gram-positive bacteria. The best-studied member of the PAAT (polar amino acid transport) family is the HisJQMP system of S. typhimurium, where HisJ is the extracellular solute binding proteins and HisP is the ABC protein. Pssm-ID: 213229 [Multi-domain] Cd Length: 213 Bit Score: 39.05 E-value: 1.57e-03
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| PRK10851 | PRK10851 | sulfate/thiosulfate ABC transporter ATP-binding protein CysA; |
143-180 | 1.63e-03 | |||||
sulfate/thiosulfate ABC transporter ATP-binding protein CysA; Pssm-ID: 182778 [Multi-domain] Cd Length: 353 Bit Score: 39.68 E-value: 1.63e-03
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| cbiO | PRK13643 | energy-coupling factor transporter ATPase; |
132-184 | 1.69e-03 | |||||
energy-coupling factor transporter ATPase; Pssm-ID: 184203 [Multi-domain] Cd Length: 288 Bit Score: 39.33 E-value: 1.69e-03
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| btuD | PRK09536 | corrinoid ABC transporter ATPase; Reviewed |
137-182 | 1.79e-03 | |||||
corrinoid ABC transporter ATPase; Reviewed Pssm-ID: 236554 [Multi-domain] Cd Length: 402 Bit Score: 39.82 E-value: 1.79e-03
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| cbiO | PRK13649 | energy-coupling factor transporter ATPase; |
143-182 | 1.87e-03 | |||||
energy-coupling factor transporter ATPase; Pssm-ID: 184208 [Multi-domain] Cd Length: 280 Bit Score: 39.34 E-value: 1.87e-03
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| cbiO | PRK13644 | energy-coupling factor transporter ATPase; |
126-182 | 2.01e-03 | |||||
energy-coupling factor transporter ATPase; Pssm-ID: 106587 [Multi-domain] Cd Length: 274 Bit Score: 39.20 E-value: 2.01e-03
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| cbiO | PRK13647 | cobalt transporter ATP-binding subunit; Provisional |
141-185 | 2.27e-03 | |||||
cobalt transporter ATP-binding subunit; Provisional Pssm-ID: 237457 [Multi-domain] Cd Length: 274 Bit Score: 38.95 E-value: 2.27e-03
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| ABCC_CFTR2 | cd03289 | ATP-binding cassette domain 2 of CFTR,subfamily C; The cystic fibrosis transmembrane regulator ... |
140-241 | 2.56e-03 | |||||
ATP-binding cassette domain 2 of CFTR,subfamily C; The cystic fibrosis transmembrane regulator (CFTR), the product of the gene mutated in patients with cystic fibrosis, has adapted the ABC transporter structural motif to form a tightly regulated anion channel at the apical surface of many epithelia. Use of the term assembly of a functional ion channel implies the coming together of subunits or at least smaller not-yet functional components of the active whole. In fact, on the basis of current knowledge only the CFTR polypeptide itself is required to form an ATP- and protein kinase A-dependent low-conductance chloride channel of the type present in the apical membrane of many epithelial cells. CFTR displays the typical organization (IM-ABC)2 and carries a characteristic hydrophilic R-domain that separates IM1-ABC1 from IM2-ABC2. Pssm-ID: 213256 [Multi-domain] Cd Length: 275 Bit Score: 38.68 E-value: 2.56e-03
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| potG | PRK11607 | putrescine ABC transporter ATP-binding subunit PotG; |
115-182 | 2.89e-03 | |||||
putrescine ABC transporter ATP-binding subunit PotG; Pssm-ID: 183226 [Multi-domain] Cd Length: 377 Bit Score: 39.05 E-value: 2.89e-03
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| DnaC | COG1484 | DNA replication protein DnaC [Replication, recombination and repair]; |
126-172 | 2.92e-03 | |||||
DNA replication protein DnaC [Replication, recombination and repair]; Pssm-ID: 441093 [Multi-domain] Cd Length: 242 Bit Score: 38.61 E-value: 2.92e-03
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| IS21_help_AAA | NF038214 | IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ... |
133-167 | 3.40e-03 | |||||
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements. Pssm-ID: 439516 Cd Length: 232 Bit Score: 38.22 E-value: 3.40e-03
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| PRK13536 | PRK13536 | nodulation factor ABC transporter ATP-binding protein NodI; |
126-185 | 5.90e-03 | |||||
nodulation factor ABC transporter ATP-binding protein NodI; Pssm-ID: 237419 [Multi-domain] Cd Length: 340 Bit Score: 37.89 E-value: 5.90e-03
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| PRK11000 | PRK11000 | maltose/maltodextrin ABC transporter ATP-binding protein MalK; |
137-180 | 6.95e-03 | |||||
maltose/maltodextrin ABC transporter ATP-binding protein MalK; Pssm-ID: 182893 [Multi-domain] Cd Length: 369 Bit Score: 37.70 E-value: 6.95e-03
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| cbiO | PRK13646 | energy-coupling factor transporter ATPase; |
141-184 | 7.74e-03 | |||||
energy-coupling factor transporter ATPase; Pssm-ID: 184205 [Multi-domain] Cd Length: 286 Bit Score: 37.45 E-value: 7.74e-03
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| ugpC | PRK11650 | sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC; |
139-182 | 8.95e-03 | |||||
sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC; Pssm-ID: 236947 [Multi-domain] Cd Length: 356 Bit Score: 37.52 E-value: 8.95e-03
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| PRK11147 | PRK11147 | ABC transporter ATPase component; Reviewed |
136-173 | 9.20e-03 | |||||
ABC transporter ATPase component; Reviewed Pssm-ID: 236861 [Multi-domain] Cd Length: 635 Bit Score: 37.62 E-value: 9.20e-03
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| PRK13651 | PRK13651 | cobalt transporter ATP-binding subunit; Provisional |
141-183 | 9.95e-03 | |||||
cobalt transporter ATP-binding subunit; Provisional Pssm-ID: 184210 [Multi-domain] Cd Length: 305 Bit Score: 36.99 E-value: 9.95e-03
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| PRK15112 | PRK15112 | peptide ABC transporter ATP-binding protein SapF; |
141-182 | 9.98e-03 | |||||
peptide ABC transporter ATP-binding protein SapF; Pssm-ID: 185067 [Multi-domain] Cd Length: 267 Bit Score: 37.08 E-value: 9.98e-03
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