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Conserved domains on  [gi|1174098743|ref|NP_001337067|]
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zinc finger MYM-type protein 4 isoform 2 [Homo sapiens]

Protein Classification

zf-FCS and DUF3504 domain-containing protein( domain architecture ID 10534361)

protein containing domains TRASH, zf-FCS, and DUF3504

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3504 pfam12012
Domain of unknown function (DUF3504); This presumed domain is functionally uncharacterized. ...
 1324-1494 1.19e-86

Domain of unknown function (DUF3504); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 156 to 173 amino acids in length.


:

Pssm-ID: 463430  Cd Length: 162  Bit Score: 279.15  E-value: 1.19e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098743 1324 MFSRIEEEHLWECKQLGAYSPIVLLNTLLFFNTKYFQLKNVTEHLKLSFAHVMRRTRTLKYsTKMTYLRFFPPlqkqese 1403
Cdd:pfam12012    1 VFSRVEEEHLWECKQLGAHSPIVLLNTLVYFNTKYFNLRTVEEHRRLSFSNVVRHTKPNPR-EKSTYLRYYEP------- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098743 1404 PDKLTVGKRKRNEDDEVPVgVEMAENTDNPLRCPVRLYEFYLSKCSESVKQRNDVFYLQPERSCVPNSPMWYSTFPIDPG 1483
Cdd:pfam12012   73 PDQVETGGRKKRDEGVNKV-VEQHENSENPLRCPVKLYEFYLSKCPESVKQRKDVFYLQPEPSCVPDSPLWYSSQPLGRN 151

                          170
                   ....*....|.
gi 1174098743 1484 TLDTMLTRILM 1494
Cdd:pfam12012  152 TLESMLTRILL 162
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 449-489 8.94e-07

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


:

Pssm-ID: 428958  Cd Length: 40  Bit Score: 46.59  E-value: 8.94e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1174098743  449 LTMNCCENCGGYCYSGSGQcHMLQIEGQSKKFCSSSCITAY 489
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTV-IVLQNDGSVGQFCSQSCLDSY 40
TRASH smart00746
metallochaperone-like domain;
357-397 8.64e-06

metallochaperone-like domain;


:

Pssm-ID: 214799  Cd Length: 39  Bit Score: 43.90  E-value: 8.64e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1174098743   357 CSSCSKDILNPKDVISAQFENTTtsKDFCSQSCLSTYELKK 397
Cdd:smart00746    1 CSFCGKDIYNPGTGIMVVNDGKV--YYFCSSKCLSKFKKKR 39
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 304-341 2.61e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


:

Pssm-ID: 428958  Cd Length: 40  Bit Score: 39.66  E-value: 2.61e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1174098743  304 AVRVSCSGCKKILQKGQTAY--QRKGSTQLFCSTLCLTGY 341
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVIvlQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 693-728 8.08e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


:

Pssm-ID: 428958  Cd Length: 40  Bit Score: 38.51  E-value: 8.08e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1174098743  693 VMAMCEYCKIEKIVKET---VRFSGADKSFCSEGCKLLY 728
Cdd:pfam06467    2 VKATCWFCKKLIKNKPTvivLQNDGSVGQFCSQSCLDSY 40
TRASH smart00746
metallochaperone-like domain;
499-537 5.16e-03

metallochaperone-like domain;


:

Pssm-ID: 214799  Cd Length: 39  Bit Score: 36.20  E-value: 5.16e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1174098743   499 CALCKSLRSSAEMIENTNSLGKTELFCSVNCLSAYRVKM 537
Cdd:smart00746    1 CSFCGKDIYNPGTGIMVVNDGKVYYFCSSKCLSKFKKKR 39
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 651-687 6.39e-03

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


:

Pssm-ID: 428958  Cd Length: 40  Bit Score: 35.81  E-value: 6.39e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1174098743  651 VKLKCQHCNRLFATKPEL--LDYKGKMFQFCGKNCSDEY 687
Cdd:pfam06467    2 VKATCWFCKKLIKNKPTVivLQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 740-774 9.96e-03

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


:

Pssm-ID: 428958  Cd Length: 40  Bit Score: 35.42  E-value: 9.96e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1174098743  740 CKMCSYC---LQTSPKLVQNNLGGKVEEFCCEECMSKY 774
Cdd:pfam06467    3 KATCWFCkklIKNKPTVIVLQNDGSVGQFCSQSCLDSY 40
 
Name Accession Description Interval E-value
DUF3504 pfam12012
Domain of unknown function (DUF3504); This presumed domain is functionally uncharacterized. ...
 1324-1494 1.19e-86

Domain of unknown function (DUF3504); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 156 to 173 amino acids in length.


Pssm-ID: 463430  Cd Length: 162  Bit Score: 279.15  E-value: 1.19e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098743 1324 MFSRIEEEHLWECKQLGAYSPIVLLNTLLFFNTKYFQLKNVTEHLKLSFAHVMRRTRTLKYsTKMTYLRFFPPlqkqese 1403
Cdd:pfam12012    1 VFSRVEEEHLWECKQLGAHSPIVLLNTLVYFNTKYFNLRTVEEHRRLSFSNVVRHTKPNPR-EKSTYLRYYEP------- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098743 1404 PDKLTVGKRKRNEDDEVPVgVEMAENTDNPLRCPVRLYEFYLSKCSESVKQRNDVFYLQPERSCVPNSPMWYSTFPIDPG 1483
Cdd:pfam12012   73 PDQVETGGRKKRDEGVNKV-VEQHENSENPLRCPVKLYEFYLSKCPESVKQRKDVFYLQPEPSCVPDSPLWYSSQPLGRN 151

                          170
                   ....*....|.
gi 1174098743 1484 TLDTMLTRILM 1494
Cdd:pfam12012  152 TLESMLTRILL 162
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 449-489 8.94e-07

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 46.59  E-value: 8.94e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1174098743  449 LTMNCCENCGGYCYSGSGQcHMLQIEGQSKKFCSSSCITAY 489
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTV-IVLQNDGSVGQFCSQSCLDSY 40
TRASH smart00746
metallochaperone-like domain;
357-397 8.64e-06

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 43.90  E-value: 8.64e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1174098743   357 CSSCSKDILNPKDVISAQFENTTtsKDFCSQSCLSTYELKK 397
Cdd:smart00746    1 CSFCGKDIYNPGTGIMVVNDGKV--YYFCSSKCLSKFKKKR 39
TRASH smart00746
metallochaperone-like domain;
454-492 9.63e-06

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 43.90  E-value: 9.63e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1174098743   454 CENCGGYCYSGSGQcHMLQIEGQSKKFCSSSCITAYKQK 492
Cdd:smart00746    1 CSFCGKDIYNPGTG-IMVVNDGKVYYFCSSKCLSKFKKK 38
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 352-393 6.52e-05

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 41.59  E-value: 6.52e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1174098743  352 LTKKTCSSCSKDILNPKDVIsaQFENTTTSKDFCSQSCLSTY 393
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVI--VLQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 304-341 2.61e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 39.66  E-value: 2.61e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1174098743  304 AVRVSCSGCKKILQKGQTAY--QRKGSTQLFCSTLCLTGY 341
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVIvlQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 693-728 8.08e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 38.51  E-value: 8.08e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1174098743  693 VMAMCEYCKIEKIVKET---VRFSGADKSFCSEGCKLLY 728
Cdd:pfam06467    2 VKATCWFCKKLIKNKPTvivLQNDGSVGQFCSQSCLDSY 40
TRASH smart00746
metallochaperone-like domain;
499-537 5.16e-03

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 36.20  E-value: 5.16e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1174098743   499 CALCKSLRSSAEMIENTNSLGKTELFCSVNCLSAYRVKM 537
Cdd:smart00746    1 CSFCGKDIYNPGTGIMVVNDGKVYYFCSSKCLSKFKKKR 39
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 651-687 6.39e-03

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 35.81  E-value: 6.39e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1174098743  651 VKLKCQHCNRLFATKPEL--LDYKGKMFQFCGKNCSDEY 687
Cdd:pfam06467    2 VKATCWFCKKLIKNKPTVivLQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 740-774 9.96e-03

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 35.42  E-value: 9.96e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1174098743  740 CKMCSYC---LQTSPKLVQNNLGGKVEEFCCEECMSKY 774
Cdd:pfam06467    3 KATCWFCkklIKNKPTVIVLQNDGSVGQFCSQSCLDSY 40
 
Name Accession Description Interval E-value
DUF3504 pfam12012
Domain of unknown function (DUF3504); This presumed domain is functionally uncharacterized. ...
 1324-1494 1.19e-86

Domain of unknown function (DUF3504); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 156 to 173 amino acids in length.


Pssm-ID: 463430  Cd Length: 162  Bit Score: 279.15  E-value: 1.19e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098743 1324 MFSRIEEEHLWECKQLGAYSPIVLLNTLLFFNTKYFQLKNVTEHLKLSFAHVMRRTRTLKYsTKMTYLRFFPPlqkqese 1403
Cdd:pfam12012    1 VFSRVEEEHLWECKQLGAHSPIVLLNTLVYFNTKYFNLRTVEEHRRLSFSNVVRHTKPNPR-EKSTYLRYYEP------- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098743 1404 PDKLTVGKRKRNEDDEVPVgVEMAENTDNPLRCPVRLYEFYLSKCSESVKQRNDVFYLQPERSCVPNSPMWYSTFPIDPG 1483
Cdd:pfam12012   73 PDQVETGGRKKRDEGVNKV-VEQHENSENPLRCPVKLYEFYLSKCPESVKQRKDVFYLQPEPSCVPDSPLWYSSQPLGRN 151

                          170
                   ....*....|.
gi 1174098743 1484 TLDTMLTRILM 1494
Cdd:pfam12012  152 TLESMLTRILL 162
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 449-489 8.94e-07

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 46.59  E-value: 8.94e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1174098743  449 LTMNCCENCGGYCYSGSGQcHMLQIEGQSKKFCSSSCITAY 489
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTV-IVLQNDGSVGQFCSQSCLDSY 40
TRASH smart00746
metallochaperone-like domain;
357-397 8.64e-06

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 43.90  E-value: 8.64e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1174098743   357 CSSCSKDILNPKDVISAQFENTTtsKDFCSQSCLSTYELKK 397
Cdd:smart00746    1 CSFCGKDIYNPGTGIMVVNDGKV--YYFCSSKCLSKFKKKR 39
TRASH smart00746
metallochaperone-like domain;
454-492 9.63e-06

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 43.90  E-value: 9.63e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1174098743   454 CENCGGYCYSGSGQcHMLQIEGQSKKFCSSSCITAYKQK 492
Cdd:smart00746    1 CSFCGKDIYNPGTG-IMVVNDGKVYYFCSSKCLSKFKKK 38
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 352-393 6.52e-05

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 41.59  E-value: 6.52e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1174098743  352 LTKKTCSSCSKDILNPKDVIsaQFENTTTSKDFCSQSCLSTY 393
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVI--VLQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 304-341 2.61e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 39.66  E-value: 2.61e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1174098743  304 AVRVSCSGCKKILQKGQTAY--QRKGSTQLFCSTLCLTGY 341
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVIvlQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 693-728 8.08e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 38.51  E-value: 8.08e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1174098743  693 VMAMCEYCKIEKIVKET---VRFSGADKSFCSEGCKLLY 728
Cdd:pfam06467    2 VKATCWFCKKLIKNKPTvivLQNDGSVGQFCSQSCLDSY 40
TRASH smart00746
metallochaperone-like domain;
499-537 5.16e-03

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 36.20  E-value: 5.16e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1174098743   499 CALCKSLRSSAEMIENTNSLGKTELFCSVNCLSAYRVKM 537
Cdd:smart00746    1 CSFCGKDIYNPGTGIMVVNDGKVYYFCSSKCLSKFKKKR 39
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 651-687 6.39e-03

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 35.81  E-value: 6.39e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1174098743  651 VKLKCQHCNRLFATKPEL--LDYKGKMFQFCGKNCSDEY 687
Cdd:pfam06467    2 VKATCWFCKKLIKNKPTVivLQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 740-774 9.96e-03

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 35.42  E-value: 9.96e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1174098743  740 CKMCSYC---LQTSPKLVQNNLGGKVEEFCCEECMSKY 774
Cdd:pfam06467    3 KATCWFCkklIKNKPTVIVLQNDGSVGQFCSQSCLDSY 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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