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Conserved domains on  [gi|1154491847|ref|NP_001336195|]
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transmembrane and coiled-coil domains protein 1 isoform a [Homo sapiens]

Protein Classification

transmembrane and coiled-coil domain protein( domain architecture ID 11186040)

transmembrane and coiled-coil domain protein may be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Tmemb_cc2 pfam10267
Predicted transmembrane and coiled-coil 2 protein; This family of transmembrane coiled-coil ...
230-638 0e+00

Predicted transmembrane and coiled-coil 2 protein; This family of transmembrane coiled-coil containing proteins is conserved from worms to humans. Its function is unknown.


:

Pssm-ID: 463036  Cd Length: 401  Bit Score: 580.06  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154491847 230 TKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIKQVFEKKNQKSAQTILQLQKKLEHYHRKLREV 309
Cdd:pfam10267   1 SRAAIEHLQQKILKIKEQIKIEQTARDENVAEYLKLANNADKQQLARIKQVFEKKNQKSAQNIAQLQKKLEQYHRRLKEL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154491847 310 EQNGIP-----RQPKDVFRDMHQGLKDVGAkvtgfsegvvdSVKGGFSSFSQAThsaAGAVVSKPREIASLIRNKFGSAD 384
Cdd:pfam10267  81 ENGEQSsvtshRQPKEVLRDVGQGLRDVGG-----------NIRDGISGLSGGP---PPTVFSKPREFAHLIKNKFGSAD 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154491847 385 NIPNLKDSLEEGQVDDAGKALG-VISNFQSSPKYGSEEDCSSATSGSVGANSTTGGIAVGASSSKTNTLDMQSSGFDALL 463
Cdd:pfam10267 147 NINSLKSSLETSHDEGGGRKLSgSTFSTVTKPKYPSDDECSSSSVESISAGSNGNPPPHGADNGGQQAESDSQNGLAAIL 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154491847 464 HEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYE 543
Cdd:pfam10267 227 EELQEIKEAQVQLEEKLERLKTQFKKEYKFLTQALQEERYRYERLEEQLNDLTELHQNEIANLKQELASMEEKVAYQSYE 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154491847 544 RARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATARNLLGKLINILLAVMAVLLVFVSTVANCVVPLMKTRNRTFS 623
Cdd:pfam10267 307 RARDIQEALESCQTRISKMELQQQQQQLVQLEGLENANARALLGKLINIVLAILTVILVLVSTAAKFVAPLLKTRLRILT 386
                         410
                  ....*....|....*
gi 1154491847 624 TLFLVVFIAFLWKHW 638
Cdd:pfam10267 387 TILLVLLLIIFWKNW 401
 
Name Accession Description Interval E-value
Tmemb_cc2 pfam10267
Predicted transmembrane and coiled-coil 2 protein; This family of transmembrane coiled-coil ...
230-638 0e+00

Predicted transmembrane and coiled-coil 2 protein; This family of transmembrane coiled-coil containing proteins is conserved from worms to humans. Its function is unknown.


Pssm-ID: 463036  Cd Length: 401  Bit Score: 580.06  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154491847 230 TKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIKQVFEKKNQKSAQTILQLQKKLEHYHRKLREV 309
Cdd:pfam10267   1 SRAAIEHLQQKILKIKEQIKIEQTARDENVAEYLKLANNADKQQLARIKQVFEKKNQKSAQNIAQLQKKLEQYHRRLKEL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154491847 310 EQNGIP-----RQPKDVFRDMHQGLKDVGAkvtgfsegvvdSVKGGFSSFSQAThsaAGAVVSKPREIASLIRNKFGSAD 384
Cdd:pfam10267  81 ENGEQSsvtshRQPKEVLRDVGQGLRDVGG-----------NIRDGISGLSGGP---PPTVFSKPREFAHLIKNKFGSAD 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154491847 385 NIPNLKDSLEEGQVDDAGKALG-VISNFQSSPKYGSEEDCSSATSGSVGANSTTGGIAVGASSSKTNTLDMQSSGFDALL 463
Cdd:pfam10267 147 NINSLKSSLETSHDEGGGRKLSgSTFSTVTKPKYPSDDECSSSSVESISAGSNGNPPPHGADNGGQQAESDSQNGLAAIL 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154491847 464 HEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYE 543
Cdd:pfam10267 227 EELQEIKEAQVQLEEKLERLKTQFKKEYKFLTQALQEERYRYERLEEQLNDLTELHQNEIANLKQELASMEEKVAYQSYE 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154491847 544 RARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATARNLLGKLINILLAVMAVLLVFVSTVANCVVPLMKTRNRTFS 623
Cdd:pfam10267 307 RARDIQEALESCQTRISKMELQQQQQQLVQLEGLENANARALLGKLINIVLAILTVILVLVSTAAKFVAPLLKTRLRILT 386
                         410
                  ....*....|....*
gi 1154491847 624 TLFLVVFIAFLWKHW 638
Cdd:pfam10267 387 TILLVLLLIIFWKNW 401
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
462-634 3.10e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.52  E-value: 3.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154491847 462 LLHEIQEIRETQARLEESFETLKEHYQRdyslIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQS 541
Cdd:COG4717   130 LYQELEALEAELAELPERLEELEERLEE----LRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQ 205
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154491847 542 yERARDIQEALEACQTRISKMElqqqqqqvVQLEGLENATARNLLGKLIN---ILLAVMAVLLVFVSTVANcvvpLMKTR 618
Cdd:COG4717   206 -QRLAELEEELEEAQEELEELE--------EELEQLENELEAAALEERLKearLLLLIAAALLALLGLGGS----LLSLI 272
                         170
                  ....*....|....*.
gi 1154491847 619 NRTFSTLFLVVFIAFL 634
Cdd:COG4717   273 LTIAGVLFLVLGLLAL 288
 
Name Accession Description Interval E-value
Tmemb_cc2 pfam10267
Predicted transmembrane and coiled-coil 2 protein; This family of transmembrane coiled-coil ...
230-638 0e+00

Predicted transmembrane and coiled-coil 2 protein; This family of transmembrane coiled-coil containing proteins is conserved from worms to humans. Its function is unknown.


Pssm-ID: 463036  Cd Length: 401  Bit Score: 580.06  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154491847 230 TKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIKQVFEKKNQKSAQTILQLQKKLEHYHRKLREV 309
Cdd:pfam10267   1 SRAAIEHLQQKILKIKEQIKIEQTARDENVAEYLKLANNADKQQLARIKQVFEKKNQKSAQNIAQLQKKLEQYHRRLKEL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154491847 310 EQNGIP-----RQPKDVFRDMHQGLKDVGAkvtgfsegvvdSVKGGFSSFSQAThsaAGAVVSKPREIASLIRNKFGSAD 384
Cdd:pfam10267  81 ENGEQSsvtshRQPKEVLRDVGQGLRDVGG-----------NIRDGISGLSGGP---PPTVFSKPREFAHLIKNKFGSAD 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154491847 385 NIPNLKDSLEEGQVDDAGKALG-VISNFQSSPKYGSEEDCSSATSGSVGANSTTGGIAVGASSSKTNTLDMQSSGFDALL 463
Cdd:pfam10267 147 NINSLKSSLETSHDEGGGRKLSgSTFSTVTKPKYPSDDECSSSSVESISAGSNGNPPPHGADNGGQQAESDSQNGLAAIL 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154491847 464 HEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYE 543
Cdd:pfam10267 227 EELQEIKEAQVQLEEKLERLKTQFKKEYKFLTQALQEERYRYERLEEQLNDLTELHQNEIANLKQELASMEEKVAYQSYE 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154491847 544 RARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATARNLLGKLINILLAVMAVLLVFVSTVANCVVPLMKTRNRTFS 623
Cdd:pfam10267 307 RARDIQEALESCQTRISKMELQQQQQQLVQLEGLENANARALLGKLINIVLAILTVILVLVSTAAKFVAPLLKTRLRILT 386
                         410
                  ....*....|....*
gi 1154491847 624 TLFLVVFIAFLWKHW 638
Cdd:pfam10267 387 TILLVLLLIIFWKNW 401
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
462-634 3.10e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.52  E-value: 3.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154491847 462 LLHEIQEIRETQARLEESFETLKEHYQRdyslIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQS 541
Cdd:COG4717   130 LYQELEALEAELAELPERLEELEERLEE----LRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQ 205
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154491847 542 yERARDIQEALEACQTRISKMElqqqqqqvVQLEGLENATARNLLGKLIN---ILLAVMAVLLVFVSTVANcvvpLMKTR 618
Cdd:COG4717   206 -QRLAELEEELEEAQEELEELE--------EELEQLENELEAAALEERLKearLLLLIAAALLALLGLGGS----LLSLI 272
                         170
                  ....*....|....*.
gi 1154491847 619 NRTFSTLFLVVFIAFL 634
Cdd:COG4717   273 LTIAGVLFLVLGLLAL 288
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
460-563 6.34e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 39.90  E-value: 6.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154491847  460 DALLHEIQEIRETQARLEESFETLKEhyqrdyslIMQTLQEERYRCERLEEQLNDLTEL--HQNEILNLKQELASMEE-- 535
Cdd:COG4913    613 AALEAELAELEEELAEAEERLEALEA--------ELDALQERREALQRLAEYSWDEIDVasAEREIAELEAELERLDAss 684
                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1154491847  536 ---KIAYQSYERAR----DIQEALEACQTRISKME 563
Cdd:COG4913    685 ddlAALEEQLEELEaeleELEEELDELKGEIGRLE 719
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
461-553 8.14e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.53  E-value: 8.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154491847 461 ALLHEIQEIRETQARLEESFETLK---EHYQRDYSLIMQTLQEERYRCERLEEQLNDLtelhQNEILNLKQELASMEEKI 537
Cdd:COG1196   229 LLLLKLRELEAELEELEAELEELEaelEELEAELAELEAELEELRLELEELELELEEA----QAEEYELLAELARLEQDI 304
                          90
                  ....*....|....*.
gi 1154491847 538 AYQSyERARDIQEALE 553
Cdd:COG1196   305 ARLE-ERRRELEERLE 319
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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