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Conserved domains on  [gi|1151099445|ref|NP_001336037|]
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alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform 6 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 12-237 0e+00

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467703  Cd Length: 226  Bit Score: 500.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  12 CDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVVSHTSVPLLLKNPDYFFKEANTTIYVIWG 91
Cdd:cd23975     1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPLLLKNPDYFFKETNETIYVIWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  92 PFRNMRKDGNGIVYNMLKKTVGIYPNAQIYVTTEKRMSYCDGVFKKETGKDRVQSGSYLSTGWFTFLLAMDACYGIHVYG 171
Cdd:cd23975    81 PFRNMRKDGKGIVYNMLKKAVESYPQAKIYVTTEKRMSYCDTVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHVYG 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1151099445 172 MINDTYCKTEGYRKVPYHYYEQGRDECDEYFLHEHAPYGGHRFITEKKVFAKWAKKHRIIFTHPNW 237
Cdd:cd23975   161 MINDTYCKTEGYRKVPYHYYEPGRDECDEYFLHENAPYGGHRFITEKKVFAKWAKKHPITFTHPNW 226
 
Name Accession Description Interval E-value
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 12-237 0e+00

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 500.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  12 CDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVVSHTSVPLLLKNPDYFFKEANTTIYVIWG 91
Cdd:cd23975     1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPLLLKNPDYFFKETNETIYVIWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  92 PFRNMRKDGNGIVYNMLKKTVGIYPNAQIYVTTEKRMSYCDGVFKKETGKDRVQSGSYLSTGWFTFLLAMDACYGIHVYG 171
Cdd:cd23975    81 PFRNMRKDGKGIVYNMLKKAVESYPQAKIYVTTEKRMSYCDTVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHVYG 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1151099445 172 MINDTYCKTEGYRKVPYHYYEQGRDECDEYFLHEHAPYGGHRFITEKKVFAKWAKKHRIIFTHPNW 237
Cdd:cd23975   161 MINDTYCKTEGYRKVPYHYYEPGRDECDEYFLHENAPYGGHRFITEKKVFAKWAKKHPITFTHPNW 226
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 12-227 1.09e-21

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 89.97  E-value: 1.09e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  12 CDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVVSHTSVP---------------------L 70
Cdd:pfam00777  43 CRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIdskygnlgfshprdpfvefvlV 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  71 LLKNPDYFF-KEANTTIYVIWGPFRNMRKDGNGIvyNMLKKTVgIYPNAQIyvttekrMSYCDGVFKKETGKDrvqsGSY 149
Cdd:pfam00777 123 PFKGRDLLWlPAFLTKGNVSRSLRVLYTLKEVKI--PVDPDKV-LFLHPDF-------LRYVANFWLRSHGLK----GRR 188

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1151099445 150 LSTGWFTFLLAMDACYGIHVYGMINDtycktEGYRKVPYHYYEQGRDecdeyflHEHAPYGGHRFITEKKVFAKWAKK 227
Cdd:pfam00777 189 PSTGLLMLSLALHLCDEVSLYGFGPF-----LDSRGNSHHYYDNVLM-------KKGGFYGVHDMPFEFKLLQKLHKE 254
 
Name Accession Description Interval E-value
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 12-237 0e+00

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 500.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  12 CDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVVSHTSVPLLLKNPDYFFKEANTTIYVIWG 91
Cdd:cd23975     1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPLLLKNPDYFFKETNETIYVIWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  92 PFRNMRKDGNGIVYNMLKKTVGIYPNAQIYVTTEKRMSYCDGVFKKETGKDRVQSGSYLSTGWFTFLLAMDACYGIHVYG 171
Cdd:cd23975    81 PFRNMRKDGKGIVYNMLKKAVESYPQAKIYVTTEKRMSYCDTVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHVYG 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1151099445 172 MINDTYCKTEGYRKVPYHYYEQGRDECDEYFLHEHAPYGGHRFITEKKVFAKWAKKHRIIFTHPNW 237
Cdd:cd23975   161 MINDTYCKTEGYRKVPYHYYEPGRDECDEYFLHENAPYGGHRFITEKKVFAKWAKKHPITFTHPNW 226
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 12-235 1.56e-128

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 362.33  E-value: 1.56e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  12 CDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVVSHTSVPLLLKNPD-YFFKEANTTIYVIW 90
Cdd:cd23965     1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVSHSSLPRLLRNAIlLLAGTRAPTVVVFW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  91 GPFRNMRKDGNGIvYNMLKKTVGIYPNAQIYVTTEKRMSYCDGVFKKETGKDRVQSGSYLSTGWFTFLLAMDACYGIHVY 170
Cdd:cd23965    81 GPETKMNKDGAGK-YNLLRSLSKKYPDVEFYSLTPEKMDYADELFEKETGKSRIKSGTWLSTGWFTMLLALDVCDEIKVY 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1151099445 171 GMINDTYCKTEGYRKVPYHYYEQGR-DECDEYFLHEHAPYGGHRFITEKKVFAKWAKKHRIIFTHP 235
Cdd:cd23965   160 GMVPENYCREHPNSKVPYHYYEPGGlKECTYYNYHENALKGGHRFITEKAVFARWAKKYNITFHHP 225
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 12-238 1.78e-119

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 339.53  E-value: 1.78e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  12 CDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVVSHTSVPLLLKNPDYFFKEANTTIYVIWG 91
Cdd:cd23977     1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPLLLRNQGYFFQQSRDTKYVIWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  92 PFRNMRKDGNGIVYNMLKKTVGIYPNAQIYVTTEKRMSYCDGVFKKETGKDRVQSGSYLSTGWFTFLLAMDACYGIHVYG 171
Cdd:cd23977    81 PERNMDRDGGGKTYRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNETGKNRMKSGSFLSTGWFTMILALELCEEILVYG 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1151099445 172 MINDTYCKTEGYRKVPYHYYEQGR-DECDEYFLHEHAPYGGHRFITEKKVFAKWAKKHRIIFTHPNWT 238
Cdd:cd23977   161 MVSDSYCRNKNHSSVPYHYYEKGRlDECRMYLVHERAPRGGHRFITEKAIFSRWAKRKKIRFAHPSWT 228
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 12-237 3.39e-91

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 267.88  E-value: 3.39e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  12 CDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVVSHTSVPLLLKNPDYFFKEANTTIYVIWG 91
Cdd:cd23978     1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYRVLRRPQEFLNRTPETTLIFWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  92 PFRNMRKDGNGIVYNMLKKTVGIYPNAQIYVTTEKRMSYCDGVFKKETGKDRVQSGSYLSTGWFTFLLAMDACYGIHVYG 171
Cdd:cd23978    81 PPNKMQKDGKSNLFRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSWLSTGWFTMVIAVELCDNVHVYG 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1151099445 172 MINDTYC-KTEGYRKVPYHYYE-QGRDECDEYFLHEHAPYGG-HRFITEKKVFAKWAKKHRIIFTHPNW 237
Cdd:cd23978   161 MVPPNYCsKRPTPKKMPYHYYEpKGPDECVTYIQNEHGRRGNhHRFITEKRVFARWAEHYNITFSHPSW 229
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 6-237 1.10e-85

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 254.79  E-value: 1.10e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445   6 KPLQLDCDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVVSHTSVPLLLKNPDYFFKEANTT 85
Cdd:cd23976     9 KPLKMHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNELLNVSQGT 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  86 IYVIWGPFRNMRKDGNGIVYNMLKKTVGIYPNAQIYVTTEKRMSYCDGVFKKETGKDRVQSGSYLSTGWFTFLLAMDACY 165
Cdd:cd23976    89 VFIFWGPSNYMRRDGKGLVYNNLQLMNQILPKLKVYTITRHKMLQFDELFKRETGKDRKISNTWLSTGWFTMIIALELCD 168

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1151099445 166 GIHVYGMINDTYCKTEGYRKVPYHYYE-QGRDECDEYFLHEHAPYGG-HRFITEKKVFAKWAKKHRIIFTHPNW 237
Cdd:cd23976   169 RINVYGMVPPDFCRDPNHPSVPYHYYEpSGPDECTMYISHERGRKGShHRFITEKRVFANWARTFNIHFYQPDW 242
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 15-224 1.07e-51

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 166.38  E-value: 1.07e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  15 CAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVVSHTSVPLLLKNPDYFF---KEANTTIYVIWG 91
Cdd:cd19952     1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGChplPLEEEVVLILSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  92 PFRNMRKDgngivynmLKKTVGIYPNAQIYVTTE--KRMSYCDGVFKKETGKDrVQSGSYLSTGWFTFLLAMDACYGIHV 169
Cdd:cd19952    81 AAAADFKR--------LKRRKKRHDNAVLLLTDPapDLLSYVRKRLEKLGLKS-FFGGNAPSSGLLAVLLALQLCDSVDL 151

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1151099445 170 YGMINDtyckTEGYRKVPYHYYEQGRDECdeyflhehaPYGGHRFITEKKVFAKW 224
Cdd:cd19952   152 YGFGVD----SGHAPKVPYHYYDLVEAEE---------GTAVHSFDLEAELLRAL 193
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 12-227 1.09e-21

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 89.97  E-value: 1.09e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  12 CDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVVSHTSVP---------------------L 70
Cdd:pfam00777  43 CRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIdskygnlgfshprdpfvefvlV 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  71 LLKNPDYFF-KEANTTIYVIWGPFRNMRKDGNGIvyNMLKKTVgIYPNAQIyvttekrMSYCDGVFKKETGKDrvqsGSY 149
Cdd:pfam00777 123 PFKGRDLLWlPAFLTKGNVSRSLRVLYTLKEVKI--PVDPDKV-LFLHPDF-------LRYVANFWLRSHGLK----GRR 188

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1151099445 150 LSTGWFTFLLAMDACYGIHVYGMINDtycktEGYRKVPYHYYEQGRDecdeyflHEHAPYGGHRFITEKKVFAKWAKK 227
Cdd:pfam00777 189 PSTGLLMLSLALHLCDEVSLYGFGPF-----LDSRGNSHHYYDNVLM-------KKGGFYGVHDMPFEFKLLQKLHKE 254
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 5-228 3.40e-18

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 81.72  E-value: 3.40e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445   5 LKPLQLDCDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVVS-HTSVPLLLKNPDYFFKEAN 83
Cdd:cd23973    76 SPPGGDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTaHSITSSLMILQKRGFKNIP 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  84 TTIYVIWGPFRNMRKDGNGIVYNMLKKTV--GIYpnaqiyvTTEKRMSYCDGVFKKETG-----------KDRVQSGSYL 150
Cdd:cd23973   156 QDKDIKYILFPEGPRDYQWLEALLKNKTIpsGAY-------YGRRPRSYFSGDFTEDKYlvlhpdflryvKNRFLRSKTL 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445 151 ----------STGWFTFLLAMDACYGIHVYGMIndtyckTEGYRKVPYHYYEQgrdecdeyflhEHAP---YGGHRFITE 217
Cdd:cd23973   229 kgkywaiyrpTTGAFLLLTALHLCDTVSAYGFI------TEDYRKYPDHYYDK-----------KKTKlvfYINHDFRLE 291

                         250
                  ....*....|.
gi 1151099445 218 KKVfakWAKKH 228
Cdd:cd23973   292 KKL---WKRLH 299
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 15-92 7.54e-16

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 74.61  E-value: 7.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  15 CAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVVSHTsvpLLLKNPDYFFKEA---NTTIyVIWG 91
Cdd:cd23968    48 CAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRLINSQ---ILSKPEFNFLTDPlyrNVTL-LVWD 123


                  .
gi 1151099445  92 P 92
Cdd:cd23968   124 P 124
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 15-196 8.18e-16

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 74.49  E-value: 8.18e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  15 CAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVVSHTsvplLLKNPDYFFKEAN---TTIYVIWG 91
Cdd:cd23986    52 CAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQ----ILTNPNHHFIDSSlykDVILVAWD 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  92 P---FRNMRKDGNGIVYNMLKKTVGI---YPNAQIYVTTEKRMSYCDGVFKKETgKDRVQSGSyLSTGWFTFLLAMDACY 165
Cdd:cd23986   128 PapySANLHKWYKKPDYNLFTPYVQYrkrNPNQPFYILHPKFIWQLWDIIQENT-QEKIQPNP-PSSGFIGILIMMSMCR 205

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1151099445 166 GIHVYGMIndtycktEGYRKVPY-HYYEQGRD 196
Cdd:cd23986   206 EVHVYEYI-------PSVRQTDLcHYHERYYD 230
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 15-192 6.80e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 71.91  E-value: 6.80e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  15 CAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGR----MTMIRVVSHTSVPLLLKNPDY-----FFKEANTT 85
Cdd:cd23963    66 CAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRktnlTTLNPSILKRRYNSLKKNRDRdkflnRLKEYNGS 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  86 IyvIWGPFRNMRKDGNGI--VYNMLKKTVG----IYPNAQIYVTTEKrmsycdgvFKKETGKDRvqsgsYLSTGWFTFLL 159
Cdd:cd23963   146 I--LWYPKFSFKSSTNLLlkAARALKKNGLnltvVYSNPEHFLAVQK--------FWKRRGLEK-----RPSTGLYLVSL 210

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1151099445 160 AMDACYGIHVYGMindtY--CKTEGYRKVPYHYYE 192
Cdd:cd23963   211 ALTFCDEIHLYGF----WpfPTDPNGRPVPYHYYD 241
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 12-232 1.06e-14

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 71.54  E-value: 1.06e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  12 CDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVV---------SHTSVPLL-LKNPDY-FFK 80
Cdd:cd23966    77 CRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMypesavdldPGVHLVLVpFKVLDLqWLI 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  81 EANTTIYVIWGPFRnMRKdgngiVYNMLKKTVGIYPNAQIYvttekrmsYcdgVFKKETGKdrvqSGSYLSTGWFTFLLA 160
Cdd:cd23966   157 SALTTGEITRTYTP-VKR-----FIKADKDKVLVINPAFIK--------Y---VHDNWTEH----HGRYPSTGFLALIFA 215

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1151099445 161 MDACYGIHVYGMINDTYckteGYRkvpYHYYEqgrdecDEYFLHEHAPYGGHRFITEKKVFAKWAKKHRIIF 232
Cdd:cd23966   216 LHICDEVSVFGFGADSK----GNW---HHYWE------KNRSAGAFRKTGVHDADFESDIIKKLAKEGKIRV 274
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 15-92 9.19e-14

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 68.58  E-value: 9.19e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  15 CAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVVSHTsvplLLKNPDY-FFKEA--NTTIYVIWG 91
Cdd:cd23985    48 CAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLINSQ----LVTTEKHkFLKDSlyNEGILIVWD 123


                  .
gi 1151099445  92 P 92
Cdd:cd23985   124 P 124
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 11-63 3.78e-13

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 66.16  E-value: 3.78e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1151099445  11 DCDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVV 63
Cdd:cd23967     1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMF 53
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 13-192 2.18e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 65.11  E-value: 2.18e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  13 DLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTmirvvshtsvPLLLKNP---DYFFKEAnTTIYVI 89
Cdd:cd23970    69 NTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKT----------NLTTFNPsilEKYYNNL-LTIQDR 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  90 WGPFRNMRKDGNGIVY---------NMLKKTVGIY-------PNAQIYVTTEKrMSYCDGVFKKETGKDRvqsgsYLSTG 153
Cdd:cd23970   138 NNFFLSLKKLDGAILWipafffhtsATVTRTLVDFfvehrgqLKVQLAWPGNI-MQHVNRYWKTKHLSPK-----RLSTG 211

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1151099445 154 WFTFLLAMDACYGIHVYGMINDTYCKTEgyRKVPYHYYE 192
Cdd:cd23970   212 ILMYTLASAICEEIHLYGFWPFGFDPTG--TPLPYHYYD 248
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 11-229 2.95e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 64.59  E-value: 2.95e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  11 DCDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMT-----MIR--VVSHTSVPLLLKNPDYFF--KE 81
Cdd:cd23964    81 RCIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTsfytfFPEslHNSLLKHVPQDKDTKYLFipFK 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  82 ANTTIYVI----WGPFRNMrKDGNGIVYNMLKKTVG------IYPNAQIYVTTekrmSYCdgvfkketgkdRVQSGSYLS 151
Cdd:cd23964   161 IRDYDYLDavlsGKPVPDG-CDKGKRPPPLFGPKLNatnvrlLHPDFIRYLFN----RWL-----------NSSTSYRPT 224

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1151099445 152 TGWFTFLLAMDACYGIHVYGMINDtycktegyRKVPYHYYEQGRdecdeyflHEHAP-YGGHRFITEKKVfakWAKKHR 229
Cdd:cd23964   225 TGALMLLTALHTCDQVSVYGFGYD--------PRFSLHYYDKTF--------VKFTVfYANHDFTNERKL---WRKLHE 284
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 12-195 5.16e-12

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 63.74  E-value: 5.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  12 CDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRmtmiRVVSHTSVPLLLKNpdyffKEANTTIYVIwg 91
Cdd:cd23979    80 CRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGS----RTTHHFMYPESAKN-----LPANVSFVLV-- 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  92 PFR--NMRKDGNGIVYNMLKKTVGiyPNAQ-IYVTTEKRMSYCDGVFKKETGKDRVQSGSYLSTGWFTFLLAMDACYGIH 168
Cdd:cd23979   149 PFKtlDLLWITSALSTGQIRFTYA--PVKQfLRVDKDKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVN 226

                         170       180
                  ....*....|....*....|....*..
gi 1151099445 169 VYGMINDTycktegyRKVPYHYYEQGR 195
Cdd:cd23979   227 VYGFGADS-------RGNWHHYWENNR 246
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 11-194 1.27e-11

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 61.60  E-value: 1.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  11 DCDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVVSHTSVplllkNPDYFFKEANTTIYVIW 90
Cdd:cd23982     1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESA-----QFDPGIENDPDTLLVLV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  91 gPFRNMrkDGNGIvYNMLKKT-----VGIYPNAQIYVTTEKRMSYCDGVFKKETG------KDRVQSGSYLSTGWFTFLL 159
Cdd:cd23982    76 -PFKPL--DFYWL-YEILSNEkrvrkGFWKQPPRIWDANPKQIRILNPYYTYVAAtkllqvPGQRKKKQKPTTGLLAITL 151

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1151099445 160 AMDACYGIHVYGMindtyckteGY-----RKVPYHYYEQG 194
Cdd:cd23982   152 ALHLCDEVHIAGF---------GYpdngnSNQPIHYYNQI 182
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 12-176 3.31e-11

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 61.44  E-value: 3.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  12 CDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVVSHTSvplllknpdyfFKEANTTIYVIWG 91
Cdd:cd23980    81 CRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPES-----------FRELAQNVSMILV 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  92 PFRNMrkDGNGIVYNMLKKTVG---IYPNAQIYVTTEKRMSYCDGVFKKETGKDRVQSGSYLSTGWFTFLLAMDACYGIH 168
Cdd:cd23980   150 PFKTL--DLEWVISATTTGTIShtyVPVPRKIKVKKEKILIYHPAFIKYVFDRWLQGHGRYPSTGILSVIFSLHVCDEVD 227


                  ....*...
gi 1151099445 169 VYGMINDT 176
Cdd:cd23980   228 LYGFGADS 235
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 15-195 9.95e-10

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 57.42  E-value: 9.95e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  15 CAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGR----MTMirvvsHTSVPlllknPDYFFKEANTTIYVIW 90
Cdd:cd23969    67 CAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTksnlTTM-----NPSVI-----PHAYGDLVNATDKEKF 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  91 gpFRNMRKDGNGIVY------NMLKKTV----GIYPNAQIYVTTEKRMSYCDGVFKK--ETGKDRVQSGsylSTGWFTFL 158
Cdd:cd23969   137 --VERLRQLGDSILWipafvsKGGEEHVqwtnEIILKHKLNVKTAYPPLRLNHAIRGywLTTKFRIKRP---STGLLMYT 211

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1151099445 159 LAMDACYGIHVYGMI---NDTYCktegyRKVPYHYYEQGR 195
Cdd:cd23969   212 LATRFCDEIHLYGFYpfsEDGNG-----RAVKYHYYDNRK 246
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 11-70 1.24e-09

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 56.29  E-value: 1.24e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  11 DCDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVVSHTSVPL 70
Cdd:cd23983     1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPK 60
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 12-192 3.42e-09

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 55.14  E-value: 3.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  12 CDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVVSHTSVpllLKNPDYFfkEANTTIYVIwg 91
Cdd:cd23984     2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESI---FSDPSHY--DPNTTVVLI-- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  92 PFRnmRKDGNGIVYNMLKKTVG------------IYPNAQIYVTTE---KRMSYcdGVFKKETGKDRVQSGSYLSTGWFT 156
Cdd:cd23984    75 PFK--PHDLRWLLDLLMGKKVSakgfwkkpalnlIYKPNQIRILNPfilRIAAY--ELLHFPKRFPKEKKPKHPTTGIIA 150

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1151099445 157 FLLAMDACYGIHVYGMindTYCKTEgyRKVPYHYYE 192
Cdd:cd23984   151 ITLALHICNEVHIAGF---KYDFSN--LNSTLHYYG 181
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 12-62 1.14e-08

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 53.39  E-value: 1.14e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1151099445  12 CDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRV 62
Cdd:cd23981     2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRI 52
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 12-229 1.24e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 51.29  E-value: 1.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  12 CDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVVS---------------HTSVPLLLKN-- 74
Cdd:cd23974    84 CIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFStntlmnslrayagvgFNGPPQSKETry 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  75 ---PD-----YFFKEANTTIYVIWGPFRNmRKDGNGIVYNMLKKTVGIY-PNAQIYVttekRMSYCDGVFKKETGKDRVQ 145
Cdd:cd23974   164 iflPDhdrdyLLVKAALTHTPIDRGRDKS-KRPSKYFGKDVTAEKFKIYhPDFIRYL----RNRFLWSPILNTKQRDIYR 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445 146 SgsylSTGWFTFLLAMDACYGIHVYGMIndtyckTEGYRKVPYHYYEQGRdecdeyflHEHAPYGGHRFITEKKVfakWA 225
Cdd:cd23974   239 P----STGAVMLLAALHTCDQVSAYGFM------TPDYGKYSDHYYDKTY--------HKVVFYANHDLRLEMQL---WQ 297


                  ....
gi 1151099445 226 KKHR 229
Cdd:cd23974   298 KLHK 301
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 15-192 3.49e-07

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 49.95  E-value: 3.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  15 CAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGrmtmirvvshTSVPLLLKNPdyffkeanTTIYVIWGPFR 94
Cdd:cd23988    67 CAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVG----------TKSDFITMNP--------SVVQRAFGGFR 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  95 NmRKDGNGIVY--NMLKKTVGIYPnAQIYVTTEKRMSYCDGVFKKETGKDRVQ----------SGSYL---------STG 153
Cdd:cd23988   129 N-ESDREKFVHrlSMLNDSVLWIP-AFMVKGGEKHVEWVNALILKNKLKVRTAypslrlihavRGYWLtnkvnikrpSTG 206

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1151099445 154 WFTFLLAMDACYGIHVYGMIndTYCKTEGYRKVPYHYYE 192
Cdd:cd23988   207 LLMYTLATRFCDEIHLYGFW--PFPKDANGNPVKYHYYD 243
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 12-58 5.07e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 49.44  E-value: 5.07e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1151099445  12 CDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMT 58
Cdd:cd23972    82 CIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKT 128
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 7-192 6.55e-07

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 49.06  E-value: 6.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445   7 PLQLDCDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAP-TKGYEEDVGRMTMirvvshtsvpLLLKNPDYFFKEANTT 85
Cdd:cd23989    58 PLQLPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPlSREYTDDVGTKTQ----------LVTANPSIIDKRFQNL 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  86 IYVIWGPFRNMRKDGNGIVY-NMLKKTVGIYPNAQIYVT-----TEKRMSYCDGVFKKETG---KDRVQSGSYLSTGWFT 156
Cdd:cd23989   128 LWSRKSFVESMKVYGRSYIYmPAFSMKTGTDPSLRVYYTladvgANQTVLFANPNFLRNVGkfwKSKGVHAKRLSTGLFL 207

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1151099445 157 FLLAMDACYGIHVYGMIndTYCKTEGYRKVPYHYYE 192
Cdd:cd23989   208 VSAALGLCEEVTIYGFW--PFSVDLDERTISHHYYD 241
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 15-192 9.54e-06

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 45.70  E-value: 9.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  15 CAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGrmtmirvvshTSVPLLLKNPDYF---FKEANTTIY---- 87
Cdd:cd23987    67 CAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVG----------TKTDLVTMNPSVVqraFEDLVNETWkekf 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151099445  88 ----------VIWGPfRNMRKDGNGIVY----NMLKKTVGI---YPNAQI------YVTTEKRMsycdgvFKKETgkdrv 144
Cdd:cd23987   137 lqrlqslngsILWIP-AFMAKGGEERVEwvndLILKHHINVrtaYPSLRLlhavrgYWLTNKVH------IKRPT----- 204

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1151099445 145 qsgsylsTGWFTFLLAMDACYGIHVYGMIndTYCKTEGYRKVPYHYYE 192
Cdd:cd23987   205 -------TGLLMYTLATRFCNRIHLYGFW--PFPRDQNQNPVKYHYYD 243
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 15-58 1.04e-03

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 39.35  E-value: 1.04e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1151099445  15 CAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKG-YEEDVGRMT 58
Cdd:cd23991    67 CAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKT 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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