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Conserved domains on  [gi|1126724272|ref|NP_001334942|]
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zinc finger protein 136 isoform 2 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
91-460 1.70e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 1.70e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724272  91 THEIIHTGEKLYDC--KECGKTFFSLKRIRRHIITHSGYTPYKCKVCGKAFDYPSRFRTHERSHTGE-KPYECQECGKAF 167
Cdd:COG5048    51 RHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSnDNNLLSSHSLPP 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724272 168 TCITSVRRHMIKHTGDGPYKCKVCGKPFHSLSSFQvhERIHTGEKPFKCKQCGKAFScsptLRIHERTHTGEKPYECKQC 247
Cdd:COG5048   131 SSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSN--SLHPPLPANSLSKDPSSNLS----LLISSNVSTSIPSSSENSP 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724272 248 GKAFSYLPSLRLHERIHTGEKPFVCKQCGKAFRSASTFQIHERTHTGEKPYECKECGEAFSCIPSMRRHMIKHTGEG--- 324
Cdd:COG5048   205 LSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSsek 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724272 325 ----PYKCKVCGKPFHSLSPFRIHERT--HTGE--KPYVCKH--CGKAFVSSTSIRIHERTHTGEKPYECK--QCGKAFS 392
Cdd:COG5048   285 gfslPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFS 364

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1126724272 393 YLNSFRTHEMIH-----TGEKPFEC--KRCGKAFRSSSSFRLHERTHTGQKPYHCK--ECGKAYSCRASFQRHMLTH 460
Cdd:COG5048   365 PLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIH 441
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
91-460 1.70e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 1.70e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724272  91 THEIIHTGEKLYDC--KECGKTFFSLKRIRRHIITHSGYTPYKCKVCGKAFDYPSRFRTHERSHTGE-KPYECQECGKAF 167
Cdd:COG5048    51 RHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSnDNNLLSSHSLPP 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724272 168 TCITSVRRHMIKHTGDGPYKCKVCGKPFHSLSSFQvhERIHTGEKPFKCKQCGKAFScsptLRIHERTHTGEKPYECKQC 247
Cdd:COG5048   131 SSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSN--SLHPPLPANSLSKDPSSNLS----LLISSNVSTSIPSSSENSP 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724272 248 GKAFSYLPSLRLHERIHTGEKPFVCKQCGKAFRSASTFQIHERTHTGEKPYECKECGEAFSCIPSMRRHMIKHTGEG--- 324
Cdd:COG5048   205 LSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSsek 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724272 325 ----PYKCKVCGKPFHSLSPFRIHERT--HTGE--KPYVCKH--CGKAFVSSTSIRIHERTHTGEKPYECK--QCGKAFS 392
Cdd:COG5048   285 gfslPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFS 364

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1126724272 393 YLNSFRTHEMIH-----TGEKPFEC--KRCGKAFRSSSSFRLHERTHTGQKPYHCK--ECGKAYSCRASFQRHMLTH 460
Cdd:COG5048   365 PLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
229-253 7.12e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.12e-04
                          10        20
                  ....*....|....*....|....*
gi 1126724272 229 LRIHERTHTGEKPYECKQCGKAFSY 253
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
91-460 1.70e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 1.70e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724272  91 THEIIHTGEKLYDC--KECGKTFFSLKRIRRHIITHSGYTPYKCKVCGKAFDYPSRFRTHERSHTGE-KPYECQECGKAF 167
Cdd:COG5048    51 RHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSnDNNLLSSHSLPP 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724272 168 TCITSVRRHMIKHTGDGPYKCKVCGKPFHSLSSFQvhERIHTGEKPFKCKQCGKAFScsptLRIHERTHTGEKPYECKQC 247
Cdd:COG5048   131 SSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSN--SLHPPLPANSLSKDPSSNLS----LLISSNVSTSIPSSSENSP 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724272 248 GKAFSYLPSLRLHERIHTGEKPFVCKQCGKAFRSASTFQIHERTHTGEKPYECKECGEAFSCIPSMRRHMIKHTGEG--- 324
Cdd:COG5048   205 LSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSsek 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724272 325 ----PYKCKVCGKPFHSLSPFRIHERT--HTGE--KPYVCKH--CGKAFVSSTSIRIHERTHTGEKPYECK--QCGKAFS 392
Cdd:COG5048   285 gfslPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFS 364

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1126724272 393 YLNSFRTHEMIH-----TGEKPFEC--KRCGKAFRSSSSFRLHERTHTGQKPYHCK--ECGKAYSCRASFQRHMLTH 460
Cdd:COG5048   365 PLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
128-441 1.75e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 1.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724272 128 TPYKCKVCGKAFDYPSRFRTHERSHTGEKPYEC--QECGKAFTCITSVRRHMIKHTGDGPYKCKVCGKPFHS-LSSFQVH 204
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSkASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724272 205 ERIHTGEKPFKCKQCGKAFSCSPTLRIHERTHTGEKPYECKQCGKAFSYLP-SLRLHERIHTGEKPfvckqcgKAFRSAS 283
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqSNSLHPPLPANSLS-------KDPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724272 284 TFQIHERTHTGEKPYECKECGEAFSCIPSMRRHMIKHTGEGPYKCKVCGKPFH----SLSPFRIHERTHTGEKPYVCKHC 359
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPksllSQSPSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724272 360 G--KAFVSSTSIRIHERTHTG-EKPYECKQCGKAFSYLNSFRTH--EMIHTGE--KPFEC--KRCGKAFRSSSSFRLHER 430
Cdd:COG5048   265 LptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALKRHIL 344

                         330
                  ....*....|.
gi 1126724272 431 THTGQKPYHCK 441
Cdd:COG5048   345 LHTSISPAKEK 355
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
193-402 2.21e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 2.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724272 193 KPFHSLSSFQVHERIHTG-EKPFKCKQCGKAFSCSPTLRIHERT--HTGE--KPYEC--KQCGKAFSYLPSLRLHERIHT 265
Cdd:COG5048   268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724272 266 GEKPFVCK--QCGKAFRSASTFQIHERT--HTGEKPYECKECGEAFSCIPSMRRHmikhtgegpykckvcgkpfhslsPF 341
Cdd:COG5048   348 SISPAKEKllNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETLSNSCIRNFKRDS-----------------------NL 404

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1126724272 342 RIHERTHTGEKPYVCK--HCGKAFVSSTSIRIHERTHTGEKPYECKQCGKAFSYLNSFRTHEM 402
Cdd:COG5048   405 SLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
127-289 9.34e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 9.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724272 127 YTPYKCKVCGKAFDYPSRFRTHERS--HTGE--KPYEC--QECGKAFTCITSVRRHMIKHTGDGPYKCK--VCGKPFHSL 198
Cdd:COG5048   287 SLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPL 366

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724272 199 S-----SFQVHERIHTGEKPFKC--KQCGKAFSCSPTLRIHERTHTGEKPYECK--QCGKAFSYLPSLRLHERIHTGEKP 269
Cdd:COG5048   367 LnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAP 446

                         170       180
                  ....*....|....*....|
gi 1126724272 270 FVCKQCGKAFRSASTFQIHE 289
Cdd:COG5048   447 LLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
268-428 1.80e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 1.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724272 268 KPFVCKQCGKAFRSASTFQIHERT--HTGE--KPYECKE--CGEAFSCIPSMRRHMIKHTGEGPYKCK--VCGKPFHSLS 339
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724272 340 PFRIHERTH-----TGEKPYVCKH--CGKAFVSSTSIRIHERTHTGEKPYECK--QCGKAFSYLNSFRTHEMIHTGEKPF 410
Cdd:COG5048   368 NNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|....*...
gi 1126724272 411 ECkRCGKAFRSSSSFRLH 428
Cdd:COG5048   448 LC-SILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
229-253 7.12e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.12e-04
                          10        20
                  ....*....|....*....|....*
gi 1126724272 229 LRIHERTHTGEKPYECKQCGKAFSY 253
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
200-225 1.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.10e-03
                          10        20
                  ....*....|....*....|....*.
gi 1126724272 200 SFQVHERIHTGEKPFKCKQCGKAFSC 225
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
256-281 1.64e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.64e-03
                          10        20
                  ....*....|....*....|....*.
gi 1126724272 256 SLRLHERIHTGEKPFVCKQCGKAFRS 281
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
144-169 1.88e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.88e-03
                          10        20
                  ....*....|....*....|....*.
gi 1126724272 144 RFRTHERSHTGEKPYECQECGKAFTC 169
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
370-393 2.81e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.81e-03
                          10        20
                  ....*....|....*....|....
gi 1126724272 370 RIHERTHTGEKPYECKQCGKAFSY 393
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
285-309 5.60e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.60e-03
                          10        20
                  ....*....|....*....|....*
gi 1126724272 285 FQIHERTHTGEKPYECKECGEAFSC 309
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
341-365 5.82e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.82e-03
                          10        20
                  ....*....|....*....|....*
gi 1126724272 341 FRIHERTHTGEKPYVCKHCGKAFVS 365
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
424-449 6.68e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.68e-03
                          10        20
                  ....*....|....*....|....*.
gi 1126724272 424 SFRLHERTHTGQKPYHCKECGKAYSC 449
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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