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Conserved domains on  [gi|1126305172|ref|NP_001334923|]
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NACHT domain- and WD repeat-containing protein 1 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
651-995 9.21e-32

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 129.26  E-value: 9.21e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  651 GGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHL 730
Cdd:COG2319     67 AGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  731 WNLLSGQekftiwdggsknpaEPQIWNLHVDEAHKVVYS------ASGS---KINAWNLETAEPVfHILGDASDPWMCMA 801
Cdd:COG2319    147 WDLATGK--------------LLRTLTGHSGAVTSVAFSpdgkllASGSddgTVRLWDLATGKLL-RTLTGHTGAVRSVA 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  802 VLASQATLLTVSRDGVVSLWSSATGKLQG--KQHMSSIKeetptcAVSVQKQGK-LVTGFSNGSISLVSSKGDRLLEKLP 878
Cdd:COG2319    212 FSPDGKLLASGSADGTVRLWDLATGKLLRtlTGHSGSVR------SVAFSPDGRlLASGSADGTVRLWDLATGELLRTLT 285

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  879 ---DAVRFLVVSEDESLLA-AGFGRSVRIF-LADSRGFRRFMAmdleHEDMVETAVFGTENNLIITGSLDALIQVWSLsE 953
Cdd:COG2319    286 ghsGGVNSVAFSPDGKLLAsGSDDGTVRLWdLATGKLLRTLTG----HTGAVRSVAFSPDGKTLASGSDDGTVRLWDL-A 360

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 1126305172  954 QGTLLDILEGVGAPVSLLA--RGGALVASASpQSSSFKVWDLSD 995
Cdd:COG2319    361 TGELLRTLTGHTGAVTSVAfsPDGRTLASGS-ADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
872-1256 2.48e-23

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.22  E-value: 2.48e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  872 RLLEKLPDAVRFLVVSEDESLLAAGFGRSVRIFLADSRGFRRfmAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWSL 951
Cdd:COG2319     30 LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALL--ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  952 SeQGTLLDILEGVGAPVSLLA--RGGALVASASpQSSSFKVWDLSDAHRSRVPAPFLDRTGLTAVSHNGSYVYFpkIGDK 1029
Cdd:COG2319    108 A-TGLLLRTLTGHTGAVRSVAfsPDGKTLASGS-ADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLAS--GSDD 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172 1030 NKVTIWDLAEGEEQDSLD-TSSEIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPPPEARkaINCMSLSKCEDRL 1108
Cdd:COG2319    184 GTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS--VRSVAFSPDGRLL 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172 1109 AIA-YDNIVLVLDITSGDPCPVIDGPrytfytqlPETLSSVAILTDYRVVYSMTN-GDLFLYECATSKAF-PLETHRSRV 1185
Cdd:COG2319    262 ASGsADGTVRLWDLATGELLRTLTGH--------SGGVNSVAFSPDGKLLASGSDdGTVRLWDLATGKLLrTLTGHTGAV 333

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1126305172 1186 ACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSycrGVQCACFSKDDKYVYVGLKDRSILVWSV 1256
Cdd:COG2319    334 RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTG---AVTSVAFSPDGRTLASGSADGTVRLWDL 401
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 108-193 1.28e-03

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member cd00009:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 151  Bit Score: 40.98  E-value: 1.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  108 GRQELLARLgQQLRHDDSKQHtpLVLFGPPGIGKTALMCKLAeqmpRLLGHKTVTVLRLlgtsQMSSDARGLLKSICFQV 187
Cdd:cd00009      2 GQEEAIEAL-REALELPPPKN--LLLYGPPGTGKTTLARAIA----NELFRPGAPFLYL----NASDLLEGLVVAELFGH 70


                   ....*.
gi 1126305172  188 CLAYGL 193
Cdd:cd00009     71 FLVRLL 76
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
651-995 9.21e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 129.26  E-value: 9.21e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  651 GGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHL 730
Cdd:COG2319     67 AGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  731 WNLLSGQekftiwdggsknpaEPQIWNLHVDEAHKVVYS------ASGS---KINAWNLETAEPVfHILGDASDPWMCMA 801
Cdd:COG2319    147 WDLATGK--------------LLRTLTGHSGAVTSVAFSpdgkllASGSddgTVRLWDLATGKLL-RTLTGHTGAVRSVA 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  802 VLASQATLLTVSRDGVVSLWSSATGKLQG--KQHMSSIKeetptcAVSVQKQGK-LVTGFSNGSISLVSSKGDRLLEKLP 878
Cdd:COG2319    212 FSPDGKLLASGSADGTVRLWDLATGKLLRtlTGHSGSVR------SVAFSPDGRlLASGSADGTVRLWDLATGELLRTLT 285

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  879 ---DAVRFLVVSEDESLLA-AGFGRSVRIF-LADSRGFRRFMAmdleHEDMVETAVFGTENNLIITGSLDALIQVWSLsE 953
Cdd:COG2319    286 ghsGGVNSVAFSPDGKLLAsGSDDGTVRLWdLATGKLLRTLTG----HTGAVRSVAFSPDGKTLASGSDDGTVRLWDL-A 360

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 1126305172  954 QGTLLDILEGVGAPVSLLA--RGGALVASASpQSSSFKVWDLSD 995
Cdd:COG2319    361 TGELLRTLTGHTGAVTSVAfsPDGRTLASGS-ADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 654-950 1.63e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.83  E-value: 1.63e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  654 LRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNL 733
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  734 LSGQEKFTIwdGGSKNPaepqIWNLHVDEAHKVVYSASGSK-INAWNLETAEPVFhILGDASDPWMCMAVLASQATLLTV 812
Cdd:cd00200     81 ETGECVRTL--TGHTSY----VSSVAFSPDGRILSSSSRDKtIKVWDVETGKCLT-TLRGHTDWVNSVAFSPDGTFVASS 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  813 SRDGVVSLWSSATGKLQG--KQHMSSIKeetpTCAVSvQKQGKLVTGFSNGSISLVSSKGDRLLEKLP---DAVRFLVVS 887
Cdd:cd00200    154 SQDGTIKLWDLRTGKCVAtlTGHTGEVN----SVAFS-PDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgheNGVNSVAFS 228

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1126305172  888 EDESLLAAG-FGRSVRIFlaDSRGFRRfMAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWS 950
Cdd:cd00200    229 PDGYLLASGsEDGTIRVW--DLRTGEC-VQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
872-1256 2.48e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.22  E-value: 2.48e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  872 RLLEKLPDAVRFLVVSEDESLLAAGFGRSVRIFLADSRGFRRfmAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWSL 951
Cdd:COG2319     30 LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALL--ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  952 SeQGTLLDILEGVGAPVSLLA--RGGALVASASpQSSSFKVWDLSDAHRSRVPAPFLDRTGLTAVSHNGSYVYFpkIGDK 1029
Cdd:COG2319    108 A-TGLLLRTLTGHTGAVRSVAfsPDGKTLASGS-ADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLAS--GSDD 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172 1030 NKVTIWDLAEGEEQDSLD-TSSEIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPPPEARkaINCMSLSKCEDRL 1108
Cdd:COG2319    184 GTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS--VRSVAFSPDGRLL 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172 1109 AIA-YDNIVLVLDITSGDPCPVIDGPrytfytqlPETLSSVAILTDYRVVYSMTN-GDLFLYECATSKAF-PLETHRSRV 1185
Cdd:COG2319    262 ASGsADGTVRLWDLATGELLRTLTGH--------SGGVNSVAFSPDGKLLASGSDdGTVRLWDLATGKLLrTLTGHTGAV 333

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1126305172 1186 ACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSycrGVQCACFSKDDKYVYVGLKDRSILVWSV 1256
Cdd:COG2319    334 RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTG---AVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 921-1255 2.08e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.23  E-value: 2.08e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  921 HEDMVETAVFGTENNLIITGSLDALIQVWSLsEQGTLLDILEGVGAPVSLLA--RGGALVASASpqsssfkvwdlsdahr 998
Cdd:cd00200      8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDL-ETGELLRTLKGHTGPVRDVAasADGTYLASGS---------------- 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  999 srvpapfLDRTgltavshngsyvyfpkigdknkVTIWDLAEGEEQDSLDT-SSEIRCLEVAEQRKLLFTGLVSGVVLVFP 1077
Cdd:cd00200     71 -------SDKT----------------------IRLWDLETGECVRTLTGhTSYVSSVAFSPDGRILSSSSRDKTIKVWD 121

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172 1078 LNSRQDVICIPPPEArkAINCMSLSKCEDRLAIA-YDNIVLVLDITSGDPCPVIDGPRytfytqlpETLSSVAILTD-YR 1155
Cdd:cd00200    122 VETGKCLTTLRGHTD--WVNSVAFSPDGTFVASSsQDGTIKLWDLRTGKCVATLTGHT--------GEVNSVAFSPDgEK 191

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172 1156 VVYSMTNGDLFLYECATSKAF-PLETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLqarkWKFEMSYTssyCRG----V 1230
Cdd:cd00200    192 LLSSSSDGTIKLWDLSTGKCLgTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDL----RTGECVQT---LSGhtnsV 264

                          330       340
                   ....*....|....*....|....*
gi 1126305172 1231 QCACFSKDDKYVYVGLKDRSILVWS 1255
Cdd:cd00200    265 TSLAWSPDGKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
697-732 5.47e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 5.47e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1126305172  697 IHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWN 732
Cdd:pfam00400    4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 108-193 1.28e-03

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 40.98  E-value: 1.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  108 GRQELLARLgQQLRHDDSKQHtpLVLFGPPGIGKTALMCKLAeqmpRLLGHKTVTVLRLlgtsQMSSDARGLLKSICFQV 187
Cdd:cd00009      2 GQEEAIEAL-REALELPPPKN--LLLYGPPGTGKTTLARAIA----NELFRPGAPFLYL----NASDLLEGLVVAELFGH 70


                   ....*.
gi 1126305172  188 CLAYGL 193
Cdd:cd00009     71 FLVRLL 76
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 105-144 1.75e-03

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 42.98  E-value: 1.75e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1126305172  105 TFCGRQELLARLGQQLRHDdSKQHTPLVLFGPPGIGKTAL 144
Cdd:NF040586     7 NFTGREELLERLRDQLRSG-GAAVVPQALHGLGGVGKTQL 45
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1178-1210 1.76e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.76e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1126305172  1178 LETHRSRVACVEVSHKEQLVVSGSEDALLCLWD 1210
Cdd:smart00320    8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
1178-1210 2.19e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 2.19e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1126305172 1178 LETHRSRVACVEVSHKEQLVVSGSEDALLCLWD 1210
Cdd:pfam00400    7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 695-732 2.58e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 2.58e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1126305172   695 HVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWN 732
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 130-296 6.79e-03

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 38.83  E-value: 6.79e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  130 PLVLFGPPGIGKTALMCKLAE--QMPRLLGHKTVTVLRLLGTSQMSSDARGLLKSICFQvclaygLPLPPAQVLDAHTRV 207
Cdd:pfam05729    2 TVILQGEAGSGKTTLLQKLALlwAQGKLPQGFDFVFFLPCRELSRSGNARSLADLLFSQ------WPEPAAPVSEVWAVI 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  208 VQFFHTLLHTVScrNFESLVLLLDAMDDLDSVRHARRvPWLPLNCPPRVHLILSACSGALGvldTLQRVLLDPEaYWEVK 287
Cdd:pfam05729   76 LELPERLLLILD--GLDELVSDLGQLDGPCPVLTLLS-SLLRKKLLPGASLLLTVRPDALR---DLRRGLEEPR-YLEVR 148


                   ....*....
gi 1126305172  288 PLSGNQGQQ 296
Cdd:pfam05729  149 GFSESDRKQ 157
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
651-995 9.21e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 129.26  E-value: 9.21e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  651 GGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHL 730
Cdd:COG2319     67 AGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  731 WNLLSGQekftiwdggsknpaEPQIWNLHVDEAHKVVYS------ASGS---KINAWNLETAEPVfHILGDASDPWMCMA 801
Cdd:COG2319    147 WDLATGK--------------LLRTLTGHSGAVTSVAFSpdgkllASGSddgTVRLWDLATGKLL-RTLTGHTGAVRSVA 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  802 VLASQATLLTVSRDGVVSLWSSATGKLQG--KQHMSSIKeetptcAVSVQKQGK-LVTGFSNGSISLVSSKGDRLLEKLP 878
Cdd:COG2319    212 FSPDGKLLASGSADGTVRLWDLATGKLLRtlTGHSGSVR------SVAFSPDGRlLASGSADGTVRLWDLATGELLRTLT 285

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  879 ---DAVRFLVVSEDESLLA-AGFGRSVRIF-LADSRGFRRFMAmdleHEDMVETAVFGTENNLIITGSLDALIQVWSLsE 953
Cdd:COG2319    286 ghsGGVNSVAFSPDGKLLAsGSDDGTVRLWdLATGKLLRTLTG----HTGAVRSVAFSPDGKTLASGSDDGTVRLWDL-A 360

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 1126305172  954 QGTLLDILEGVGAPVSLLA--RGGALVASASpQSSSFKVWDLSD 995
Cdd:COG2319    361 TGELLRTLTGHTGAVTSVAfsPDGRTLASGS-ADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 654-950 1.63e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.83  E-value: 1.63e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  654 LRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNL 733
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  734 LSGQEKFTIwdGGSKNPaepqIWNLHVDEAHKVVYSASGSK-INAWNLETAEPVFhILGDASDPWMCMAVLASQATLLTV 812
Cdd:cd00200     81 ETGECVRTL--TGHTSY----VSSVAFSPDGRILSSSSRDKtIKVWDVETGKCLT-TLRGHTDWVNSVAFSPDGTFVASS 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  813 SRDGVVSLWSSATGKLQG--KQHMSSIKeetpTCAVSvQKQGKLVTGFSNGSISLVSSKGDRLLEKLP---DAVRFLVVS 887
Cdd:cd00200    154 SQDGTIKLWDLRTGKCVAtlTGHTGEVN----SVAFS-PDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgheNGVNSVAFS 228

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1126305172  888 EDESLLAAG-FGRSVRIFlaDSRGFRRfMAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWS 950
Cdd:cd00200    229 PDGYLLASGsEDGTIRVW--DLRTGEC-VQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
651-1038 4.90e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.17  E-value: 4.90e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  651 GGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHL 730
Cdd:COG2319     25 LGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRL 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  731 WNLLSGQEKFTIWDggsknpaepqiwnlHVDEAHKVVYS------ASGS---KINAWNLETAEPVFHILGDASDPWmCMA 801
Cdd:COG2319    105 WDLATGLLLRTLTG--------------HTGAVRSVAFSpdgktlASGSadgTVRLWDLATGKLLRTLTGHSGAVT-SVA 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  802 VLASQATLLTVSRDGVVSLWSSATGKLQG--KQHMSSIKeetptcAVSVQKQGK-LVTGFSNGSISLVSSKGDRLLEKLP 878
Cdd:COG2319    170 FSPDGKLLASGSDDGTVRLWDLATGKLLRtlTGHTGAVR------SVAFSPDGKlLASGSADGTVRLWDLATGKLLRTLT 243

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  879 ---DAVRFLVVSEDESLLA-AGFGRSVRIFLADSRGFRRFMAmdlEHEDMVETAVFGTENNLIITGSLDALIQVWSLSEq 954
Cdd:COG2319    244 ghsGSVRSVAFSPDGRLLAsGSADGTVRLWDLATGELLRTLT---GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT- 319

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  955 GTLLDILEGVGAPVSLLA--RGGALVASASpQSSSFKVWDLSDAHRSRVPAPFLDRTGLTAVSHNGSYVYFpkIGDKNKV 1032
Cdd:COG2319    320 GKLLRTLTGHTGAVRSVAfsPDGKTLASGS-DDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLAS--GSADGTV 396


                   ....*.
gi 1126305172 1033 TIWDLA 1038
Cdd:COG2319    397 RLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
801-1212 2.39e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.22  E-value: 2.39e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  801 AVLASQATLLTVSRDGVVSLWSSATGKLQGKQHMSSIKEETPTCAVSVQKQGKLVTGFSNGSISLVSSKGDRLLEKLPDA 880
Cdd:COG2319      1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  881 VRFLVVSEDESLLA-AGFGRSVRIFLADSRGFRRFMAmdlEHEDMVETAVFGTENNLIITGSLDALIQVWSLsEQGTLLD 959
Cdd:COG2319     81 VLSVAFSPDGRLLAsASADGTVRLWDLATGLLLRTLT---GHTGAVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLR 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  960 ILEGVGAPVSLLA--RGGALVASASpQSSSFKVWDLSD--------AHRSRVPApfldrtglTAVSHNGSYVYFpkIGDK 1029
Cdd:COG2319    157 TLTGHSGAVTSVAfsPDGKLLASGS-DDGTVRLWDLATgkllrtltGHTGAVRS--------VAFSPDGKLLAS--GSAD 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172 1030 NKVTIWDLAEGEEQDSLDT-SSEIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPPPEARkaINCMSLSKCEDRL 1108
Cdd:COG2319    226 GTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG--VNSVAFSPDGKLL 303

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172 1109 AIA-YDNIVLVLDITSGDPCPVIDGPRYTFYtqlpetlsSVAILTD-YRVVYSMTNGDLFLYECATSKAF-PLETHRSRV 1185
Cdd:COG2319    304 ASGsDDGTVRLWDLATGKLLRTLTGHTGAVR--------SVAFSPDgKTLASGSDDGTVRLWDLATGELLrTLTGHTGAV 375

                          410       420
                   ....*....|....*....|....*..
gi 1126305172 1186 ACVEVSHKEQLVVSGSEDALLCLWDLQ 1212
Cdd:COG2319    376 TSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
872-1256 2.48e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.22  E-value: 2.48e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  872 RLLEKLPDAVRFLVVSEDESLLAAGFGRSVRIFLADSRGFRRfmAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWSL 951
Cdd:COG2319     30 LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALL--ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  952 SeQGTLLDILEGVGAPVSLLA--RGGALVASASpQSSSFKVWDLSDAHRSRVPAPFLDRTGLTAVSHNGSYVYFpkIGDK 1029
Cdd:COG2319    108 A-TGLLLRTLTGHTGAVRSVAfsPDGKTLASGS-ADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLAS--GSDD 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172 1030 NKVTIWDLAEGEEQDSLD-TSSEIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPPPEARkaINCMSLSKCEDRL 1108
Cdd:COG2319    184 GTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS--VRSVAFSPDGRLL 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172 1109 AIA-YDNIVLVLDITSGDPCPVIDGPrytfytqlPETLSSVAILTDYRVVYSMTN-GDLFLYECATSKAF-PLETHRSRV 1185
Cdd:COG2319    262 ASGsADGTVRLWDLATGELLRTLTGH--------SGGVNSVAFSPDGKLLASGSDdGTVRLWDLATGKLLrTLTGHTGAV 333

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1126305172 1186 ACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSycrGVQCACFSKDDKYVYVGLKDRSILVWSV 1256
Cdd:COG2319    334 RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTG---AVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
885-1268 5.42e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.37  E-value: 5.42e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  885 VVSEDESLLAAGFGRSVRIFLADSRGFRRFMAmdLEHEDMVETAVFGTENNLIITGSLDALIQVWsLSEQGTLLDILEGV 964
Cdd:COG2319      1 ALSADGAALAAASADLALALLAAALGALLLLL--LGLAAAVASLAASPDGARLAAGAGDLTLLLL-DAAAGALLATLLGH 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  965 GAPVSLLA--RGGALVASASPQSSsFKVWDLSDAHRSRVPAPFLDRTGLTAVSHNGSYVYFpkIGDKNKVTIWDLAEGEE 1042
Cdd:COG2319     78 TAAVLSVAfsPDGRLLASASADGT-VRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLAS--GSADGTVRLWDLATGKL 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172 1043 QDSLDT-SSEIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPPPEARkaINCMSLSKCEDRLAIA-YDNIVLVLD 1120
Cdd:COG2319    155 LRTLTGhSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA--VRSVAFSPDGKLLASGsADGTVRLWD 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172 1121 ITSGDPCPVIDGPRYTFYtqlpetlsSVAILTD-YRVVYSMTNGDLFLYECATSKA-FPLETHRSRVACVEVSHKEQLVV 1198
Cdd:COG2319    233 LATGKLLRTLTGHSGSVR--------SVAFSPDgRLLASGSADGTVRLWDLATGELlRTLTGHSGGVNSVAFSPDGKLLA 304

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172 1199 SGSEDALLCLWDLQARKWKFEMSytsSYCRGVQCACFSKDDKYVYVGLKDRSILVWSVLDGTLLTVQFVH 1268
Cdd:COG2319    305 SGSDDGTVRLWDLATGKLLRTLT---GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH 371
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 652-822 2.74e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.01  E-value: 2.74e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  652 GPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLW 731
Cdd:cd00200    125 GKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  732 NLLSGQEKFTIWdgGSKNPaepqIWNLHVDEAHKVVYSASG-SKINAWNLETAEPVFHILGDASDPWmCMAVLASQATLL 810
Cdd:cd00200    205 DLSTGKCLGTLR--GHENG----VNSVAFSPDGYLLASGSEdGTIRVWDLRTGECVQTLSGHTNSVT-SLAWSPDGKRLA 277

                          170
                   ....*....|..
gi 1126305172  811 TVSRDGVVSLWS 822
Cdd:cd00200    278 SGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 921-1255 2.08e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.23  E-value: 2.08e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  921 HEDMVETAVFGTENNLIITGSLDALIQVWSLsEQGTLLDILEGVGAPVSLLA--RGGALVASASpqsssfkvwdlsdahr 998
Cdd:cd00200      8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDL-ETGELLRTLKGHTGPVRDVAasADGTYLASGS---------------- 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  999 srvpapfLDRTgltavshngsyvyfpkigdknkVTIWDLAEGEEQDSLDT-SSEIRCLEVAEQRKLLFTGLVSGVVLVFP 1077
Cdd:cd00200     71 -------SDKT----------------------IRLWDLETGECVRTLTGhTSYVSSVAFSPDGRILSSSSRDKTIKVWD 121

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172 1078 LNSRQDVICIPPPEArkAINCMSLSKCEDRLAIA-YDNIVLVLDITSGDPCPVIDGPRytfytqlpETLSSVAILTD-YR 1155
Cdd:cd00200    122 VETGKCLTTLRGHTD--WVNSVAFSPDGTFVASSsQDGTIKLWDLRTGKCVATLTGHT--------GEVNSVAFSPDgEK 191

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172 1156 VVYSMTNGDLFLYECATSKAF-PLETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLqarkWKFEMSYTssyCRG----V 1230
Cdd:cd00200    192 LLSSSSDGTIKLWDLSTGKCLgTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDL----RTGECVQT---LSGhtnsV 264

                          330       340
                   ....*....|....*....|....*
gi 1126305172 1231 QCACFSKDDKYVYVGLKDRSILVWS 1255
Cdd:cd00200    265 TSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1049-1268 1.53e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.59  E-value: 1.53e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172 1049 SSEIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPppEARKAINCMSLSKCEDRLAIA-YDNIVLVLDITSGDPC 1127
Cdd:cd00200      9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK--GHTGPVRDVAASADGTYLASGsSDKTIRLWDLETGECV 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172 1128 pvidgprYTFyTQLPETLSSVAILTDYRVVY-SMTNGDLFLYECATSKA-FPLETHRSRVACVEVSHKEQLVVSGSEDAL 1205
Cdd:cd00200     87 -------RTL-TGHTSYVSSVAFSPDGRILSsSSRDKTIKVWDVETGKClTTLRGHTDWVNSVAFSPDGTFVASSSQDGT 158

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1126305172 1206 LCLWDLqaRKWKFEMSYTSSYcRGVQCACFSKDDKYVYVGLKDRSILVWSVLDGTLLTVQFVH 1268
Cdd:cd00200    159 IKLWDL--RTGKCVATLTGHT-GEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH 218
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 651-863 5.18e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.97  E-value: 5.18e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  651 GGPLRATLSGcHKG-ITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLH 729
Cdd:cd00200     82 TGECVRTLTG-HTSyVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  730 LWNLLSGQEKFTIwdGGSKNPaepqIWNLHVDEAHKVVYSASGSK-INAWNLETAEPVfHILGDASDPWMCMAVLASQAT 808
Cdd:cd00200    161 LWDLRTGKCVATL--TGHTGE----VNSVAFSPDGEKLLSSSSDGtIKLWDLSTGKCL-GTLRGHENGVNSVAFSPDGYL 233

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1126305172  809 LLTVSRDGVVSLWSSATGKLqgkqhMSSIKEETPTC-AVSVQKQGK-LVTGFSNGSI 863
Cdd:cd00200    234 LASGSEDGTIRVWDLRTGEC-----VQTLSGHTNSVtSLAWSPDGKrLASGSADGTI 285
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 649-732 3.81e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.66  E-value: 3.81e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  649 PPGGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTL 728
Cdd:cd00200    206 LSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285


                   ....
gi 1126305172  729 HLWN 732
Cdd:cd00200    286 RIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1178-1283 1.22e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.95  E-value: 1.22e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172 1178 LETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQarkwKFEMSYT-SSYCRGVQCACFSKDDKYVYVGLKDRSILVWSV 1256
Cdd:cd00200     47 LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE----TGECVRTlTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV 122

                           90       100
                   ....*....|....*....|....*....
gi 1126305172 1257 LDGTLLTVQFVH--AVVNRIIPTTSGFIA 1283
Cdd:cd00200    123 ETGKCLTTLRGHtdWVNSVAFSPDGTFVA 151
WD40 pfam00400
WD domain, G-beta repeat;
697-732 5.47e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 5.47e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1126305172  697 IHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWN 732
Cdd:pfam00400    4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 108-193 1.28e-03

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 40.98  E-value: 1.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  108 GRQELLARLgQQLRHDDSKQHtpLVLFGPPGIGKTALMCKLAeqmpRLLGHKTVTVLRLlgtsQMSSDARGLLKSICFQV 187
Cdd:cd00009      2 GQEEAIEAL-REALELPPPKN--LLLYGPPGTGKTTLARAIA----NELFRPGAPFLYL----NASDLLEGLVVAELFGH 70


                   ....*.
gi 1126305172  188 CLAYGL 193
Cdd:cd00009     71 FLVRLL 76
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 105-144 1.75e-03

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 42.98  E-value: 1.75e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1126305172  105 TFCGRQELLARLGQQLRHDdSKQHTPLVLFGPPGIGKTAL 144
Cdd:NF040586     7 NFTGREELLERLRDQLRSG-GAAVVPQALHGLGGVGKTQL 45
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1178-1210 1.76e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.76e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1126305172  1178 LETHRSRVACVEVSHKEQLVVSGSEDALLCLWD 1210
Cdd:smart00320    8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
1178-1210 2.19e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 2.19e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1126305172 1178 LETHRSRVACVEVSHKEQLVVSGSEDALLCLWD 1210
Cdd:pfam00400    7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 695-732 2.58e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 2.58e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1126305172   695 HVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWN 732
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 130-296 6.79e-03

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 38.83  E-value: 6.79e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  130 PLVLFGPPGIGKTALMCKLAE--QMPRLLGHKTVTVLRLLGTSQMSSDARGLLKSICFQvclaygLPLPPAQVLDAHTRV 207
Cdd:pfam05729    2 TVILQGEAGSGKTTLLQKLALlwAQGKLPQGFDFVFFLPCRELSRSGNARSLADLLFSQ------WPEPAAPVSEVWAVI 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172  208 VQFFHTLLHTVScrNFESLVLLLDAMDDLDSVRHARRvPWLPLNCPPRVHLILSACSGALGvldTLQRVLLDPEaYWEVK 287
Cdd:pfam05729   76 LELPERLLLILD--GLDELVSDLGQLDGPCPVLTLLS-SLLRKKLLPGASLLLTVRPDALR---DLRRGLEEPR-YLEVR 148


                   ....*....
gi 1126305172  288 PLSGNQGQQ 296
Cdd:pfam05729  149 GFSESDRKQ 157
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 657-710 6.93e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.26  E-value: 6.93e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1126305172  657 TLSGCHKG--ITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCV 710
Cdd:pfam12894   31 TLSPDKEDleVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCL 86
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 105-154 7.64e-03

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 38.64  E-value: 7.64e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1126305172  105 TFCGRQELLARLGQQLRHDDSKQHTPLVLFGPPGIGKTALMCKLAEQMPR 154
Cdd:pfam13191    1 RLVGREEELEQLLDALDRVRSGRPPSVLLTGEAGTGKTTLLRELLRALER 50
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 1090-1217 8.48e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 39.90  E-value: 8.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172 1090 PEARKAINCMSLS--KCEDRLAIAY-DNIVLVLDITSGDPCPVIDGPRYTFYTQLPETLSSVAILTdyRVVYSMT-NGDL 1165
Cdd:cd22857     27 PDKSKAVQALSIAdrESEPLLAVARkNGTVEVLDPENGDLLASFSDSEPATKLSEEDHFVGLHLFS--GTLLTCTsKGSL 104

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126305172 1166 FLY-----ECATSKAFPLETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQ---ARKWK 1217
Cdd:cd22857    105 RSTklpddSTASSSPTAWVCLGGNLLCMRVDPNENYFAFGGKEVELNVWDLEekpGKIWR 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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