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Conserved domains on  [gi|1031473182|ref|NP_001313515|]
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RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 [Mus musculus]

Protein Classification

RHINO domain-containing protein( domain architecture ID 10633918)

RHINO domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RHINO pfam15319
RAD9, RAD1, HUS1-interacting nuclear orphan protein; RHINO, or RAD9, RAD1, HUS1-interacting ...
1-233 4.06e-108

RAD9, RAD1, HUS1-interacting nuclear orphan protein; RHINO, or RAD9, RAD1, HUS1-interacting nuclear orphan, is a family of eukaryotic proteins. Under genotoxic stresses such as ionizing radiation during the S phase, RHINO plays a role in DNA damage response signalling. It is recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent (ataxia telangiectasia and Rad3-related) manner. It is required for the progression of the G1 to S phase transition of breast cancer cells, and it is known to play a role in the stimulation of CHEK1 phosphorylation. It interacts with RAD9A, RAD18, TOPBP1 and UBE2N.


:

Pssm-ID: 464642  Cd Length: 245  Bit Score: 311.26  E-value: 4.06e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031473182   1 MPP-KKRRRQSQKAQLLFHQQPLEGPKHHYESCQQPITHTVQVPSKPIDQSTVTSWVSPQFDRAAESRFLIHRK-PHRDQ 78
Cdd:pfam15319   1 MPPkKKRRQKSRKAQLLFHEQPLEGPKHHYGSPQRPATHPRQVPSKPIDQNTITSWVSPQFDTTAESWFPACRKkHHRDQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031473182  79 ARRPTRRST-CKFPRLTFESPQSSSSETLLLSNRVQ------PQNSEKDPPRRPLVPLFSPQSCGELSVHVPHSLPHVFA 151
Cdd:pfam15319  81 ARRSSRKSTaCKFPPLTFESPESSSSSETLGIPRTGklvqesPSQSEKDTSRRPLVPVLSPQSCGELSAHSLQSPPYVFI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031473182 152 PPDIQTPDSS-VRDDPISPDQKENSFPSCIL--GPGTPSSPEPGPVLVKDTPEEKYGIKVTWRRRRHLFAYLKEKGKLDG 228
Cdd:pfam15319 161 PPDIQTPESPgVCSSPIPPDQSENSLPSCSLpsHTSTPGSPEPGPVLVKDTPEEKYGIKVTWRRRRHLLKYLRERGKLSR 240

                  ....*
gi 1031473182 229 SQFLV 233
Cdd:pfam15319 241 SQFLV 245
 
Name Accession Description Interval E-value
RHINO pfam15319
RAD9, RAD1, HUS1-interacting nuclear orphan protein; RHINO, or RAD9, RAD1, HUS1-interacting ...
1-233 4.06e-108

RAD9, RAD1, HUS1-interacting nuclear orphan protein; RHINO, or RAD9, RAD1, HUS1-interacting nuclear orphan, is a family of eukaryotic proteins. Under genotoxic stresses such as ionizing radiation during the S phase, RHINO plays a role in DNA damage response signalling. It is recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent (ataxia telangiectasia and Rad3-related) manner. It is required for the progression of the G1 to S phase transition of breast cancer cells, and it is known to play a role in the stimulation of CHEK1 phosphorylation. It interacts with RAD9A, RAD18, TOPBP1 and UBE2N.


Pssm-ID: 464642  Cd Length: 245  Bit Score: 311.26  E-value: 4.06e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031473182   1 MPP-KKRRRQSQKAQLLFHQQPLEGPKHHYESCQQPITHTVQVPSKPIDQSTVTSWVSPQFDRAAESRFLIHRK-PHRDQ 78
Cdd:pfam15319   1 MPPkKKRRQKSRKAQLLFHEQPLEGPKHHYGSPQRPATHPRQVPSKPIDQNTITSWVSPQFDTTAESWFPACRKkHHRDQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031473182  79 ARRPTRRST-CKFPRLTFESPQSSSSETLLLSNRVQ------PQNSEKDPPRRPLVPLFSPQSCGELSVHVPHSLPHVFA 151
Cdd:pfam15319  81 ARRSSRKSTaCKFPPLTFESPESSSSSETLGIPRTGklvqesPSQSEKDTSRRPLVPVLSPQSCGELSAHSLQSPPYVFI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031473182 152 PPDIQTPDSS-VRDDPISPDQKENSFPSCIL--GPGTPSSPEPGPVLVKDTPEEKYGIKVTWRRRRHLFAYLKEKGKLDG 228
Cdd:pfam15319 161 PPDIQTPESPgVCSSPIPPDQSENSLPSCSLpsHTSTPGSPEPGPVLVKDTPEEKYGIKVTWRRRRHLLKYLRERGKLSR 240

                  ....*
gi 1031473182 229 SQFLV 233
Cdd:pfam15319 241 SQFLV 245
 
Name Accession Description Interval E-value
RHINO pfam15319
RAD9, RAD1, HUS1-interacting nuclear orphan protein; RHINO, or RAD9, RAD1, HUS1-interacting ...
1-233 4.06e-108

RAD9, RAD1, HUS1-interacting nuclear orphan protein; RHINO, or RAD9, RAD1, HUS1-interacting nuclear orphan, is a family of eukaryotic proteins. Under genotoxic stresses such as ionizing radiation during the S phase, RHINO plays a role in DNA damage response signalling. It is recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent (ataxia telangiectasia and Rad3-related) manner. It is required for the progression of the G1 to S phase transition of breast cancer cells, and it is known to play a role in the stimulation of CHEK1 phosphorylation. It interacts with RAD9A, RAD18, TOPBP1 and UBE2N.


Pssm-ID: 464642  Cd Length: 245  Bit Score: 311.26  E-value: 4.06e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031473182   1 MPP-KKRRRQSQKAQLLFHQQPLEGPKHHYESCQQPITHTVQVPSKPIDQSTVTSWVSPQFDRAAESRFLIHRK-PHRDQ 78
Cdd:pfam15319   1 MPPkKKRRQKSRKAQLLFHEQPLEGPKHHYGSPQRPATHPRQVPSKPIDQNTITSWVSPQFDTTAESWFPACRKkHHRDQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031473182  79 ARRPTRRST-CKFPRLTFESPQSSSSETLLLSNRVQ------PQNSEKDPPRRPLVPLFSPQSCGELSVHVPHSLPHVFA 151
Cdd:pfam15319  81 ARRSSRKSTaCKFPPLTFESPESSSSSETLGIPRTGklvqesPSQSEKDTSRRPLVPVLSPQSCGELSAHSLQSPPYVFI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031473182 152 PPDIQTPDSS-VRDDPISPDQKENSFPSCIL--GPGTPSSPEPGPVLVKDTPEEKYGIKVTWRRRRHLFAYLKEKGKLDG 228
Cdd:pfam15319 161 PPDIQTPESPgVCSSPIPPDQSENSLPSCSLpsHTSTPGSPEPGPVLVKDTPEEKYGIKVTWRRRRHLLKYLRERGKLSR 240

                  ....*
gi 1031473182 229 SQFLV 233
Cdd:pfam15319 241 SQFLV 245
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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