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Conserved domains on  [gi|1007383094|ref|NP_001308072|]
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lipid transferase CIDEC isoform 4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CIDE_N super family cl02541
CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) ...
 1-46 3.25e-23

CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of ICAD/DFF45, and the CAD/DFF40 and CIDE nucleases during apoptosis. The CIDE-N domain is also found in the FSP27/CIDE-C protein.


The actual alignment was detected with superfamily member cd06538:

Pssm-ID: 470607  Cd Length: 79  Bit Score: 87.18  E-value: 3.25e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1007383094   1 MLADKPFFLVLEEDGTTVETEEYFQALAGDTVFMVLQKGQKWQPPS 46
Cdd:cd06538    34 LLLDCISSLVLDEDGTGVDTEEFFQALADNTVFMVLGKGQKWKPPT 79
 
Name Accession Description Interval E-value
CIDE_N_FSP27 cd06538
CIDE_N domain of FSP27 proteins. The CIDE-N (cell death-inducing DFF45-like effector, ...
 1-46 3.25e-23

CIDE_N domain of FSP27 proteins. The CIDE-N (cell death-inducing DFF45-like effector, N-terminal) domain is found in the FSP27/CIDE-C protein, which has been identified as a n adipocyte lipid droplet protein that negatively regulates lipolysis and promotes triglyceride accumulation. The CIDE protein family includes 3 members: CIDE-A, CIDE-B, and FSP27(CIDE-C). Based on sequence similarity with DFF40 and DFF45, CIDE proteins were initially characterized as mitochondrial activators of apoptosis. The CIDE-N domain of FSP27 is sufficient to increase apoptosis in vitro when overexpressed.


Pssm-ID: 119371  Cd Length: 79  Bit Score: 87.18  E-value: 3.25e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1007383094   1 MLADKPFFLVLEEDGTTVETEEYFQALAGDTVFMVLQKGQKWQPPS 46
Cdd:cd06538    34 LLLDCISSLVLDEDGTGVDTEEFFQALADNTVFMVLGKGQKWKPPT 79
CIDE-N pfam02017
CIDE-N domain; This domain is found in CAD nuclease, and ICAD, the inhibitor of CAD nuclease. ...
 2-43 5.05e-16

CIDE-N domain; This domain is found in CAD nuclease, and ICAD, the inhibitor of CAD nuclease. The two proteins interact through this domain.


Pssm-ID: 460413  Cd Length: 75  Bit Score: 68.30  E-value: 5.05e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1007383094   2 LADKPFFLVLEEDGTTVETEEYFQALAGDTVFMVLQKGQKWQ 43
Cdd:pfam02017  34 LPSEPVTLVLEEDGTEVDDEEYFQTLPDNTELMLLEKGEKWT 75
CAD smart00266
Domains present in proteins implicated in post-mortem DNA fragmentation;
2-42 1.13e-15

Domains present in proteins implicated in post-mortem DNA fragmentation;


Pssm-ID: 128562  Cd Length: 74  Bit Score: 67.74  E-value: 1.13e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1007383094    2 LADKPFFLVLEEDGTTVETEEYFQALAGDTVFMVLQKGQKW 42
Cdd:smart00266  34 LPDSPVTLVLEEDGTIVDDEEYFQTLPDNTELMALEKGEKW 74
 
Name Accession Description Interval E-value
CIDE_N_FSP27 cd06538
CIDE_N domain of FSP27 proteins. The CIDE-N (cell death-inducing DFF45-like effector, ...
 1-46 3.25e-23

CIDE_N domain of FSP27 proteins. The CIDE-N (cell death-inducing DFF45-like effector, N-terminal) domain is found in the FSP27/CIDE-C protein, which has been identified as a n adipocyte lipid droplet protein that negatively regulates lipolysis and promotes triglyceride accumulation. The CIDE protein family includes 3 members: CIDE-A, CIDE-B, and FSP27(CIDE-C). Based on sequence similarity with DFF40 and DFF45, CIDE proteins were initially characterized as mitochondrial activators of apoptosis. The CIDE-N domain of FSP27 is sufficient to increase apoptosis in vitro when overexpressed.


Pssm-ID: 119371  Cd Length: 79  Bit Score: 87.18  E-value: 3.25e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1007383094   1 MLADKPFFLVLEEDGTTVETEEYFQALAGDTVFMVLQKGQKWQPPS 46
Cdd:cd06538    34 LLLDCISSLVLDEDGTGVDTEEFFQALADNTVFMVLGKGQKWKPPT 79
CIDE_N cd01615
CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) ...
 2-44 2.09e-17

CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of ICAD/DFF45, and the CAD/DFF40 and CIDE nucleases during apoptosis. The CIDE-N domain is also found in the FSP27/CIDE-C protein.


Pssm-ID: 119367  Cd Length: 78  Bit Score: 72.19  E-value: 2.09e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1007383094   2 LADKPFFLVLEEDGTTVETEEYFQALAGDTVFMVLQKGQKWQP 44
Cdd:cd01615    36 LPSAPVTLVLEEDGTEVDDEEYFQTLPDNTVLMLLEPGQKWTP 78
CIDE-N pfam02017
CIDE-N domain; This domain is found in CAD nuclease, and ICAD, the inhibitor of CAD nuclease. ...
 2-43 5.05e-16

CIDE-N domain; This domain is found in CAD nuclease, and ICAD, the inhibitor of CAD nuclease. The two proteins interact through this domain.


Pssm-ID: 460413  Cd Length: 75  Bit Score: 68.30  E-value: 5.05e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1007383094   2 LADKPFFLVLEEDGTTVETEEYFQALAGDTVFMVLQKGQKWQ 43
Cdd:pfam02017  34 LPSEPVTLVLEEDGTEVDDEEYFQTLPDNTELMLLEKGEKWT 75
CAD smart00266
Domains present in proteins implicated in post-mortem DNA fragmentation;
2-42 1.13e-15

Domains present in proteins implicated in post-mortem DNA fragmentation;


Pssm-ID: 128562  Cd Length: 74  Bit Score: 67.74  E-value: 1.13e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1007383094    2 LADKPFFLVLEEDGTTVETEEYFQALAGDTVFMVLQKGQKW 42
Cdd:smart00266  34 LPDSPVTLVLEEDGTIVDDEEYFQTLPDNTELMALEKGEKW 74
CIDE_N_A cd06539
CIDE_N domain of CIDE-A proteins. The CIDE_N (cell death-inducing DFF45-like effector, ...
 9-44 1.11e-14

CIDE_N domain of CIDE-A proteins. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins. These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of the CAD/DFF40, ICAD/DFF45, and CIDE nucleases during apoptosis. The CIDE protein family includes 3 members: CIDE-A, CIDE-B, and FSP27(CIDE-C). Based on sequence similarity with DFF40 and DFF45, the CIDE proteins were initially characterized as mitochondrial activators of apoptosis. However, strong metabolic phenotypes of mice lacking CIDE-A and CIDE-B indicated that this family may play critical roles in energy balance.


Pssm-ID: 119372  Cd Length: 78  Bit Score: 65.35  E-value: 1.11e-14
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1007383094   9 LVLEEDGTTVETEEYFQALAGDTVFMVLQKGQKWQP 44
Cdd:cd06539    43 LVLEEDGTVVDTEEFFQTLGDNTHFMVLEKGQKWTP 78
CIDE_N_B cd06537
CIDE_N domain of CIDE-B proteins. The CIDE_N (cell death-inducing DFF45-like effector, ...
 9-46 3.93e-13

CIDE_N domain of CIDE-B proteins. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins. These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of the CAD/DFF40, ICAD/DFF45 and CIDE nucleases during apoptosis. The CIDE protein family includes 3 members: CIDE-A, CIDE-B, and FSP27(CIDE-C). Based on sequence similarity with DFF40 and DFF45, CIDE proteins were initially characterized as mitochondrial activators of apoptosis. However, strong metabolic phenotypes of mice lacking CIDE-A and CIDE-B indicated that this family may play critical roles in energy balance.


Pssm-ID: 119370  Cd Length: 81  Bit Score: 61.08  E-value: 3.93e-13
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1007383094   9 LVLEEDGTTVETEEYFQALAGDTVFMVLQKGQKWQPPS 46
Cdd:cd06537    42 LVLEEDGTAVDSEDFFELLEDDTCLMVLEQGQSWSPKS 79
CIDE_N_ICAD cd06536
CIDE_N domain of ICAD. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) ...
 6-44 1.69e-08

CIDE_N domain of ICAD. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD (DFF45). These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of the CAD/DFF40 and ICAD/DFF45 during apoptosis. In normal cells, DFF exists in the nucleus as a heterodimer composed of CAD/DFF40 as a latent nuclease and its chaperone and inhibitor subunit ICAD/DFF45. Apoptotic activation of caspase-3 results in the cleavage of DFF45/ICAD and release of active DFF40/CAD nuclease.


Pssm-ID: 119369  Cd Length: 80  Bit Score: 49.03  E-value: 1.69e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1007383094   6 PFFLVLEEDGTTVETEEYFQALAGDTVFMVLQKGQKWQP 44
Cdd:cd06536    42 PITLVLAEDGTIVEDEDYFLCLPPNTKFVLLAENEKWAP 80
CIDE_N_CAD cd06535
CIDE_N domain of CAD nuclease. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) ...
 9-43 2.33e-04

CIDE_N domain of CAD nuclease. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of CAD/DFF40 and ICAD/DFF45 during apoptosis. In normal cells, DFF exists in the nucleus as a heterodimer composed of CAD/DFF40 as a latent nuclease and its chaperone and inhibitor subunit ICAD/DFF45. Apoptotic activation of caspase-3 results in the cleavage of DFF45/ICAD and the release of active DFF40/CAD nuclease.


Pssm-ID: 119368  Cd Length: 77  Bit Score: 37.78  E-value: 2.33e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1007383094   9 LVLEEDGTTVeTEEYFQALAGDTVFMVLQKGQKWQ 43
Cdd:cd06535    43 LCLYEDGTEV-TEEYFPTLPDNTELVLLTPGQSWQ 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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