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Conserved domains on  [gi|1002341776|ref|NP_001307537|]
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intercellular adhesion molecule 3 isoform 4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 56-135 6.59e-05

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


:

Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 40.46  E-value: 6.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002341776  56 PIVNLSEPTAHEGSTVTVSCMAGAR--VQVTLDGVPAAAPGQPAQLqLNATESDDGRSFFCSATLEVDGEflhRNSSVQL 133
Cdd:pfam13895   2 PVLTPSPTVVTEGEPVTLTCSAPGNppPSYTWYKDGSAISSSPNFF-TLSVSAEDSGTYTCVARNGRGGK---VSNPVEL 77


                  ..
gi 1002341776 134 RV 135
Cdd:pfam13895  78 TV 79
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 159-208 3.42e-04

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


:

Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 38.46  E-value: 3.42e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002341776 159 VLQCQARGNPYPELRCLKEGSSREVPVGIPFF------------VNVTHNGTYQCQASSSRG 208
Cdd:cd00096     2 TLTCSASGNPPPTITWYKNGKPLPPSSRDSRRselgngtltisnVTLEDSGTYTCVASNSAG 63
 
Name Accession Description Interval E-value
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 56-135 6.59e-05

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 40.46  E-value: 6.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002341776  56 PIVNLSEPTAHEGSTVTVSCMAGAR--VQVTLDGVPAAAPGQPAQLqLNATESDDGRSFFCSATLEVDGEflhRNSSVQL 133
Cdd:pfam13895   2 PVLTPSPTVVTEGEPVTLTCSAPGNppPSYTWYKDGSAISSSPNFF-TLSVSAEDSGTYTCVARNGRGGK---VSNPVEL 77


                  ..
gi 1002341776 134 RV 135
Cdd:pfam13895  78 TV 79
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 159-208 3.42e-04

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 38.46  E-value: 3.42e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002341776 159 VLQCQARGNPYPELRCLKEGSSREVPVGIPFF------------VNVTHNGTYQCQASSSRG 208
Cdd:cd00096     2 TLTCSASGNPPPTITWYKNGKPLPPSSRDSRRselgngtltisnVTLEDSGTYTCVASNSAG 63
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 160-211 5.41e-03

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 35.06  E-value: 5.41e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1002341776 160 LQCQARGNPYPELRCLKEGSsrEVPVGIPFF---VNVTHNGTYQCQASSSRGKYT 211
Cdd:pfam13895  19 LTCSAPGNPPPSYTWYKDGS--AISSSPNFFtlsVSAEDSGTYTCVARNGRGGKV 71
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 159-215 9.75e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 34.79  E-value: 9.75e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1002341776  159 VLQCQARGNPYPELRCLKEG-----------SSREVPVGIPFFVNVT--HNGTYQCQASSSRGKY---TLVVV 215
Cdd:smart00410  13 TLSCEASGSPPPEVTWYKQGgkllaesgrfsVSRSGSTSTLTISNVTpeDSGTYTCAATNSSGSAssgTTLTV 85
 
Name Accession Description Interval E-value
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 56-135 6.59e-05

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 40.46  E-value: 6.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002341776  56 PIVNLSEPTAHEGSTVTVSCMAGAR--VQVTLDGVPAAAPGQPAQLqLNATESDDGRSFFCSATLEVDGEflhRNSSVQL 133
Cdd:pfam13895   2 PVLTPSPTVVTEGEPVTLTCSAPGNppPSYTWYKDGSAISSSPNFF-TLSVSAEDSGTYTCVARNGRGGK---VSNPVEL 77


                  ..
gi 1002341776 134 RV 135
Cdd:pfam13895  78 TV 79
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 159-208 3.42e-04

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 38.46  E-value: 3.42e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002341776 159 VLQCQARGNPYPELRCLKEGSSREVPVGIPFF------------VNVTHNGTYQCQASSSRG 208
Cdd:cd00096     2 TLTCSASGNPPPTITWYKNGKPLPPSSRDSRRselgngtltisnVTLEDSGTYTCVASNSAG 63
IgC_1_Robo cd07693
First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar ...
 160-208 6.55e-04

First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain in Roundabout (Robo) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, Robo2, and Robo3), and three mammalian Slit homologs (Slit1, Slit2, Slit3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, Robo2, and Robo3 are expressed by commissural neurons in the vertebrate spinal cord and Slit1, Slit2,and Slit3 are expressed at the ventral midline. Robo3 is a divergent member of the Robo family which instead of being a positive regulator of Slit responsiveness, antagonizes Slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be is the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site.


Pssm-ID: 409490 [Multi-domain]  Cd Length: 99  Bit Score: 38.30  E-value: 6.55e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002341776 160 LQCQARGNPYPELRCLKEGSSRE------------VPVGIPFFVNVTHN-------GTYQCQASSSRG 208
Cdd:cd07693    20 LNCKAEGRPTPTIQWLKNGQPLEtdkddprshrivLPSGSLFFLRVVHGrkgrsdeGVYVCVAHNSLG 87
Ig3_L1-CAM_like cd05731
Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar ...
 159-214 3.37e-03

Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; The members here are composed of the third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM). L1 belongs to the L1 subfamily of cell adhesion molecules (CAMs) and is comprised of an extracellular region having six Ig-like domains and five fibronectin type III domains, a transmembrane region and an intracellular domain. L1 is primarily expressed in the nervous system and is involved in its development and function. L1 is associated with an X-linked recessive disorder, X-linked hydrocephalus, MASA syndrome, and spastic paraplegia type 1, that involves abnormalities of axonal growth. This group also contains the chicken neuron-glia cell adhesion molecule, Ng-CAM and human neurofascin.


Pssm-ID: 409394 [Multi-domain]  Cd Length: 83  Bit Score: 35.85  E-value: 3.37e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1002341776 159 VLQCQARGNPYPELRCLKEGSsrEVPVGIPFF---------VNVTH--NGTYQCQAS----SSRGKYTLVV 214
Cdd:cd05731    14 LLECIAEGLPTPDIRWIKLGG--ELPKGRTKFenfnktlkiENVSEadSGEYQCTASntmgSARHTISVTV 82
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 160-211 5.41e-03

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 35.06  E-value: 5.41e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1002341776 160 LQCQARGNPYPELRCLKEGSsrEVPVGIPFF---VNVTHNGTYQCQASSSRGKYT 211
Cdd:pfam13895  19 LTCSAPGNPPPSYTWYKDGS--AISSSPNFFtlsVSAEDSGTYTCVARNGRGGKV 71
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 159-215 9.75e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 34.79  E-value: 9.75e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1002341776  159 VLQCQARGNPYPELRCLKEG-----------SSREVPVGIPFFVNVT--HNGTYQCQASSSRGKY---TLVVV 215
Cdd:smart00410  13 TLSCEASGSPPPEVTWYKQGgkllaesgrfsVSRSGSTSTLTISNVTpeDSGTYTCAATNSSGSAssgTTLTV 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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