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Conserved domains on  [gi|970414555|ref|NP_001305095|]
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phospholipid phosphatase 4 isoform b [Homo sapiens]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 256)

type 2 phosphatidic acid phosphatase (PAP2) family protein may be a histidine phosphatase or a vanadium haloperoxidase, and is predicted to be a transmembrane protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_like super family cl00474
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 37-106 4.25e-17

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


The actual alignment was detected with superfamily member cd03390:

Pssm-ID: 469784 [Multi-domain]  Cd Length: 193  Bit Score: 75.33  E-value: 4.25e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970414555  37 WLYKNPLVQSDNIPTRLMFAISFLTPLAVICVVKIIRRTDKTEIKEAFLAVSLALALNGVCTNTIKLIVG 106
Cdd:cd03390    1 PSISYPFAESETVPTWLLVIISVGIPLLVIILISLFFRRSLWDLHTSLLGLLLSVSLNGVITNVLKNYAG 70
 
Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 37-106 4.25e-17

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 75.33  E-value: 4.25e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970414555  37 WLYKNPLVQSDNIPTRLMFAISFLTPLAVICVVKIIRRTDKTEIKEAFLAVSLALALNGVCTNTIKLIVG 106
Cdd:cd03390    1 PSISYPFAESETVPTWLLVIISVGIPLLVIILISLFFRRSLWDLHTSLLGLLLSVSLNGVITNVLKNYAG 70
PLN02250 PLN02250
lipid phosphate phosphatase
 12-106 2.07e-05

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 43.76  E-value: 2.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970414555  12 ALLFGVFVFTEFLDPFQRVIQPEEIWLYKNPLvQSDNIPTRLMFAISFLTPLAVICVVKIIRRtDKTEIKEAFLAVSLAL 91
Cdd:PLN02250  30 LLLVVIEVVLNVIEPFHRFVGKDMLTDLSYPL-QDNTIPFWAVPLIAILLPFAVILVYYFIRR-DVYDLHHAILGLLFSV 107

                         90
                 ....*....|....*
gi 970414555  92 ALNGVCTNTIKLIVG 106
Cdd:PLN02250 108 LITGVITDAIKDAVG 122
 
Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 37-106 4.25e-17

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 75.33  E-value: 4.25e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970414555  37 WLYKNPLVQSDNIPTRLMFAISFLTPLAVICVVKIIRRTDKTEIKEAFLAVSLALALNGVCTNTIKLIVG 106
Cdd:cd03390    1 PSISYPFAESETVPTWLLVIISVGIPLLVIILISLFFRRSLWDLHTSLLGLLLSVSLNGVITNVLKNYAG 70
PLN02250 PLN02250
lipid phosphate phosphatase
 12-106 2.07e-05

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 43.76  E-value: 2.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970414555  12 ALLFGVFVFTEFLDPFQRVIQPEEIWLYKNPLvQSDNIPTRLMFAISFLTPLAVICVVKIIRRtDKTEIKEAFLAVSLAL 91
Cdd:PLN02250  30 LLLVVIEVVLNVIEPFHRFVGKDMLTDLSYPL-QDNTIPFWAVPLIAILLPFAVILVYYFIRR-DVYDLHHAILGLLFSV 107

                         90
                 ....*....|....*
gi 970414555  92 ALNGVCTNTIKLIVG 106
Cdd:PLN02250 108 LITGVITDAIKDAVG 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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