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Conserved domains on  [gi|961349548|ref|NP_001304736|]
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regulator of microtubule dynamics protein 1 isoform 4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 29-167 6.30e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 40.75  E-value: 6.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961349548  29 QAAVVHATAKVEEILEQADYLYESG---ETEKLYQLLTQYKeSEDAELLWRLARASRDVAQLSrtseeekkllvyEALEY 105
Cdd:COG3914  102 RRALALNPDNAEALFNLGNLLLALGrleEALAALRRALALN-PDFAEAYLNLGEALRRLGRLE------------EAIAA 168

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 961349548 106 AKRALEKNESSFASHKWYAICLSDVGDY-EGIkakianayiikEHFEKAIELNPKDATSIHLM 167
Cdd:COG3914  169 LRRALELDPDNAEALNNLGNALQDLGRLeEAI-----------AAYRRALELDPDNADAHSNL 220
 
Name Accession Description Interval E-value
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 29-167 6.30e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 40.75  E-value: 6.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961349548  29 QAAVVHATAKVEEILEQADYLYESG---ETEKLYQLLTQYKeSEDAELLWRLARASRDVAQLSrtseeekkllvyEALEY 105
Cdd:COG3914  102 RRALALNPDNAEALFNLGNLLLALGrleEALAALRRALALN-PDFAEAYLNLGEALRRLGRLE------------EAIAA 168

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 961349548 106 AKRALEKNESSFASHKWYAICLSDVGDY-EGIkakianayiikEHFEKAIELNPKDATSIHLM 167
Cdd:COG3914  169 LRRALELDPDNAEALNNLGNALQDLGRLeEAI-----------AAYRRALELDPDNADAHSNL 220
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 101-158 2.64e-03

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 38.38  E-value: 2.64e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 961349548 101 EALEYAKRALEKNESSFASHKWYAICLSDVGDYEgiKAkianayiiKEHFEKAIELNP 158
Cdd:cd24142   18 LALKFLQRALELEPNNVEALELLGEILLELGDVE--EA--------REVLLRAIELDP 65
 
Name Accession Description Interval E-value
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 29-167 6.30e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 40.75  E-value: 6.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961349548  29 QAAVVHATAKVEEILEQADYLYESG---ETEKLYQLLTQYKeSEDAELLWRLARASRDVAQLSrtseeekkllvyEALEY 105
Cdd:COG3914  102 RRALALNPDNAEALFNLGNLLLALGrleEALAALRRALALN-PDFAEAYLNLGEALRRLGRLE------------EAIAA 168

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 961349548 106 AKRALEKNESSFASHKWYAICLSDVGDY-EGIkakianayiikEHFEKAIELNPKDATSIHLM 167
Cdd:COG3914  169 LRRALELDPDNAEALNNLGNALQDLGRLeEAI-----------AAYRRALELDPDNADAHSNL 220
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 29-168 1.57e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 39.59  E-value: 1.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961349548  29 QAAVVHATAKVEEILEQADYLYESGEtekLYQLLTQYKESEDAELLWRLARASRDVAQLSRTSEEEKKLLVY-------- 100
Cdd:COG3914   18 LAAAAAAELALAAELEAAALAAALGL---ALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALllqalgry 94

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 961349548 101 -EALEYAKRALEKNESSFASHKWYAICLSDVGDYEgiKAkianayiiKEHFEKAIELNPKDATSIHLMG 168
Cdd:COG3914   95 eEALALYRRALALNPDNAEALFNLGNLLLALGRLE--EA--------LAALRRALALNPDFAEAYLNLG 153
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 101-158 2.64e-03

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 38.38  E-value: 2.64e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 961349548 101 EALEYAKRALEKNESSFASHKWYAICLSDVGDYEgiKAkianayiiKEHFEKAIELNP 158
Cdd:cd24142   18 LALKFLQRALELEPNNVEALELLGEILLELGDVE--EA--------REVLLRAIELDP 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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