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Conserved domains on  [gi|948284327|ref|NP_001303886|]
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mth938 domain-containing protein isoform a [Homo sapiens]

Protein Classification

Mth938-like domain-containing protein( domain architecture ID 10142266)

Mth938-like domain-containing protein similar to Methanobacterium thermoautotrophicum MTH938 and human adipogenesis associated Mth938 domain-containing protein that may play a role in preadipocyte differentiation and adipogenesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mth938 cd05126
Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium ...
 5-93 6.69e-32

Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the protein has not been determined.


:

Pssm-ID: 240162  Cd Length: 117  Bit Score: 109.73  E-value: 6.69e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284327   5 EIASLSWGQMKVKGSNTTyKDCKVWPGGSRTWDWRETG--TEHSPGVQPADVKEVVEKGVQTLVIGRGMSEALKAP--TQ 80
Cdd:cd05126    1 EIESTSFGSITVGGETYE-HDIVVYPDGSRARRWKELSkkTGTSHGLQPEELEELLEEGVEVIVIGTGQSGALKVPpeTV 79

                         90
                 ....*....|...
gi 948284327  81 QLPSGVHVRAVVQ 93
Cdd:cd05126   80 EKLEKRGVEVLVL 92
 
Name Accession Description Interval E-value
Mth938 cd05126
Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium ...
 5-93 6.69e-32

Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the protein has not been determined.


Pssm-ID: 240162  Cd Length: 117  Bit Score: 109.73  E-value: 6.69e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284327   5 EIASLSWGQMKVKGSNTTyKDCKVWPGGSRTWDWRETG--TEHSPGVQPADVKEVVEKGVQTLVIGRGMSEALKAP--TQ 80
Cdd:cd05126    1 EIESTSFGSITVGGETYE-HDIVVYPDGSRARRWKELSkkTGTSHGLQPEELEELLEEGVEVIVIGTGQSGALKVPpeTV 79

                         90
                 ....*....|...
gi 948284327  81 QLPSGVHVRAVVQ 93
Cdd:cd05126   80 EKLEKRGVEVLVL 92
DUF498 pfam04430
Protein of unknown function (DUF498/DUF598); This is a large family of uncharacterized ...
 6-88 1.01e-05

Protein of unknown function (DUF498/DUF598); This is a large family of uncharacterized proteins found in all domains of life. The structure shows a novel fold with three beta sheets. A dimeric form is found in the crystal structure. It was suggested that the cleft in between the two monomers might bing nucleic acid.


Pssm-ID: 461305  Cd Length: 106  Bit Score: 41.74  E-value: 1.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284327    6 IASLSWGQMKVKGsnTTY-KDCKVWPGGSRTWDwretgTEHSPGVQPADVKEVVEKgVQTLVIGRGM-----SEALKAPT 79
Cdd:pfam04430   1 IDGYGFGGFRVNG--VRYrGSLLVLPGGVFAWD-----VTKGEDLTPEDLALLLAD-PEVLIIGTGArvlflPPELREAL 72


                  ....*....
gi 948284327   80 QQLPSGVHV 88
Cdd:pfam04430  73 RKRGIGVEV 81
 
Name Accession Description Interval E-value
Mth938 cd05126
Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium ...
 5-93 6.69e-32

Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the protein has not been determined.


Pssm-ID: 240162  Cd Length: 117  Bit Score: 109.73  E-value: 6.69e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284327   5 EIASLSWGQMKVKGSNTTyKDCKVWPGGSRTWDWRETG--TEHSPGVQPADVKEVVEKGVQTLVIGRGMSEALKAP--TQ 80
Cdd:cd05126    1 EIESTSFGSITVGGETYE-HDIVVYPDGSRARRWKELSkkTGTSHGLQPEELEELLEEGVEVIVIGTGQSGALKVPpeTV 79

                         90
                 ....*....|...
gi 948284327  81 QLPSGVHVRAVVQ 93
Cdd:cd05126   80 EKLEKRGVEVLVL 92
DUF498 pfam04430
Protein of unknown function (DUF498/DUF598); This is a large family of uncharacterized ...
 6-88 1.01e-05

Protein of unknown function (DUF498/DUF598); This is a large family of uncharacterized proteins found in all domains of life. The structure shows a novel fold with three beta sheets. A dimeric form is found in the crystal structure. It was suggested that the cleft in between the two monomers might bing nucleic acid.


Pssm-ID: 461305  Cd Length: 106  Bit Score: 41.74  E-value: 1.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284327    6 IASLSWGQMKVKGsnTTY-KDCKVWPGGSRTWDwretgTEHSPGVQPADVKEVVEKgVQTLVIGRGM-----SEALKAPT 79
Cdd:pfam04430   1 IDGYGFGGFRVNG--VRYrGSLLVLPGGVFAWD-----VTKGEDLTPEDLALLLAD-PEVLIIGTGArvlflPPELREAL 72


                  ....*....
gi 948284327   80 QQLPSGVHV 88
Cdd:pfam04430  73 RKRGIGVEV 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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