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Conserved domains on  [gi|827837314|ref|NP_001296414|]
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T-cell leukemia/lymphoma protein 1A isoform 4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TCL1_MTCP1 super family cl03378
TCL1/MTCP1 family; Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell ...
 1-80 3.97e-33

TCL1/MTCP1 family; Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell prolymphocytic leukaemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28. This family contains two repeated motifs that form a single globular domain.


The actual alignment was detected with superfamily member pfam01840:

Pssm-ID: 460358  Cd Length: 118  Bit Score: 110.56  E-value: 3.97e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827837314    1 MATQrAHRAETPAHPNRLWIWEKHVYLDEFRRSWLPVVIKSNEKFQ---------VILRQEDVTLGEAMSPSQLVPYELP 71
Cdd:pfam01840   1 MAEE-ASFPHLPSPPDRLWIWRPGIYEDENGRTWLPVVVETSGSSRgwrietqvtVHLWQMDVPPGEPMSPSQLTPSELP 79


                  ....*....
gi 827837314   72 LMWQLYPKD 80
Cdd:pfam01840  80 LMWQLYPGN 88
 
Name Accession Description Interval E-value
TCL1_MTCP1 pfam01840
TCL1/MTCP1 family; Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell ...
 1-80 3.97e-33

TCL1/MTCP1 family; Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell prolymphocytic leukaemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28. This family contains two repeated motifs that form a single globular domain.


Pssm-ID: 460358  Cd Length: 118  Bit Score: 110.56  E-value: 3.97e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827837314    1 MATQrAHRAETPAHPNRLWIWEKHVYLDEFRRSWLPVVIKSNEKFQ---------VILRQEDVTLGEAMSPSQLVPYELP 71
Cdd:pfam01840   1 MAEE-ASFPHLPSPPDRLWIWRPGIYEDENGRTWLPVVVETSGSSRgwrietqvtVHLWQMDVPPGEPMSPSQLTPSELP 79


                  ....*....
gi 827837314   72 LMWQLYPKD 80
Cdd:pfam01840  80 LMWQLYPGN 88
 
Name Accession Description Interval E-value
TCL1_MTCP1 pfam01840
TCL1/MTCP1 family; Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell ...
 1-80 3.97e-33

TCL1/MTCP1 family; Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell prolymphocytic leukaemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28. This family contains two repeated motifs that form a single globular domain.


Pssm-ID: 460358  Cd Length: 118  Bit Score: 110.56  E-value: 3.97e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827837314    1 MATQrAHRAETPAHPNRLWIWEKHVYLDEFRRSWLPVVIKSNEKFQ---------VILRQEDVTLGEAMSPSQLVPYELP 71
Cdd:pfam01840   1 MAEE-ASFPHLPSPPDRLWIWRPGIYEDENGRTWLPVVVETSGSSRgwrietqvtVHLWQMDVPPGEPMSPSQLTPSELP 79


                  ....*....
gi 827837314   72 LMWQLYPKD 80
Cdd:pfam01840  80 LMWQLYPGN 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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