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Conserved domains on  [gi|808688261|ref|NP_001294953|]
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cutA divalent cation tolerance homolog-like isoform 2 [Mus musculus]

Protein Classification

divalent-cation tolerance protein CutA( domain architecture ID 6886)

divalent-cation tolerance protein CutA is a cytoplasmic protein implicated in regulating intracellular metal homeostasis

CATH:  3.30.70.120
Gene Symbol:  cutA
Gene Ontology:  GO:0010038
SCOP:  4002632

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CutA1 super family cl00584
CutA1 divalent ion tolerance protein; Several gene loci with a possible involvement in ...
 55-107 3.75e-19

CutA1 divalent ion tolerance protein; Several gene loci with a possible involvement in cellular tolerance to copper have been identified. One such locus in eubacteria and archaebacteria, cutA, is thought to be involved in cellular tolerance to a wide variety of divalent cations other than copper. The cutA locus consists of two operons, of one and two genes. The CutA1 protein is a cytoplasmic protein, encoded by the single-gene operon and has been linked to divalent cation tolerance. It has no recognized structural motifs. This family also contains putative proteins from eukaryotes (human and Drosophila).


The actual alignment was detected with superfamily member pfam03091:

Pssm-ID: 469831  Cd Length: 98  Bit Score: 75.18  E-value: 3.75e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 808688261   55 IVFVNCPNEQIARDIARAILDKKMASSVNILPKTSSLYFWKGEIEEGIEVSLV 107
Cdd:pfam03091   1 LVYTTAPDEEEAEKIARALVEERLAACVNILPGITSIYRWEGKIEEDEEVLLL 53
 
Name Accession Description Interval E-value
CutA1 pfam03091
CutA1 divalent ion tolerance protein; Several gene loci with a possible involvement in ...
 55-107 3.75e-19

CutA1 divalent ion tolerance protein; Several gene loci with a possible involvement in cellular tolerance to copper have been identified. One such locus in eubacteria and archaebacteria, cutA, is thought to be involved in cellular tolerance to a wide variety of divalent cations other than copper. The cutA locus consists of two operons, of one and two genes. The CutA1 protein is a cytoplasmic protein, encoded by the single-gene operon and has been linked to divalent cation tolerance. It has no recognized structural motifs. This family also contains putative proteins from eukaryotes (human and Drosophila).


Pssm-ID: 460800  Cd Length: 98  Bit Score: 75.18  E-value: 3.75e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 808688261   55 IVFVNCPNEQIARDIARAILDKKMASSVNILPKTSSLYFWKGEIEEGIEVSLV 107
Cdd:pfam03091   1 LVYTTAPDEEEAEKIARALVEERLAACVNILPGITSIYRWEGKIEEDEEVLLL 53
CutA1 COG1324
Divalent cation tolerance protein CutA [Inorganic ion transport and metabolism];
52-107 2.46e-18

Divalent cation tolerance protein CutA [Inorganic ion transport and metabolism];


Pssm-ID: 440935  Cd Length: 104  Bit Score: 73.29  E-value: 2.46e-18
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 808688261  52 SYSIVFVNCPNEQIARDIARAILDKKMASSVNILPKTSSLYFWKGEIEEGIEVSLV 107
Cdd:COG1324    2 DYILVLTTAPDEEEAERIARALVEERLAACVNILPPITSVYRWQGKIEEDEEVLLL 57
PRK10645 PRK10645
divalent cation tolerance protein CutA;
55-107 2.03e-10

divalent cation tolerance protein CutA;


Pssm-ID: 182614  Cd Length: 112  Bit Score: 53.24  E-value: 2.03e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 808688261  55 IVFVNCPNEQIARDIARAILDKKMASSVNILPKTSSLYFWKGEIEEGIEVSLV 107
Cdd:PRK10645  13 VVLCTAPDEATAQDLAAKVLAEKLAACVTLLPGATSLYYWEGKLEQEYEVQML 65
 
Name Accession Description Interval E-value
CutA1 pfam03091
CutA1 divalent ion tolerance protein; Several gene loci with a possible involvement in ...
 55-107 3.75e-19

CutA1 divalent ion tolerance protein; Several gene loci with a possible involvement in cellular tolerance to copper have been identified. One such locus in eubacteria and archaebacteria, cutA, is thought to be involved in cellular tolerance to a wide variety of divalent cations other than copper. The cutA locus consists of two operons, of one and two genes. The CutA1 protein is a cytoplasmic protein, encoded by the single-gene operon and has been linked to divalent cation tolerance. It has no recognized structural motifs. This family also contains putative proteins from eukaryotes (human and Drosophila).


Pssm-ID: 460800  Cd Length: 98  Bit Score: 75.18  E-value: 3.75e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 808688261   55 IVFVNCPNEQIARDIARAILDKKMASSVNILPKTSSLYFWKGEIEEGIEVSLV 107
Cdd:pfam03091   1 LVYTTAPDEEEAEKIARALVEERLAACVNILPGITSIYRWEGKIEEDEEVLLL 53
CutA1 COG1324
Divalent cation tolerance protein CutA [Inorganic ion transport and metabolism];
52-107 2.46e-18

Divalent cation tolerance protein CutA [Inorganic ion transport and metabolism];


Pssm-ID: 440935  Cd Length: 104  Bit Score: 73.29  E-value: 2.46e-18
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 808688261  52 SYSIVFVNCPNEQIARDIARAILDKKMASSVNILPKTSSLYFWKGEIEEGIEVSLV 107
Cdd:COG1324    2 DYILVLTTAPDEEEAERIARALVEERLAACVNILPPITSVYRWQGKIEEDEEVLLL 57
PRK10645 PRK10645
divalent cation tolerance protein CutA;
55-107 2.03e-10

divalent cation tolerance protein CutA;


Pssm-ID: 182614  Cd Length: 112  Bit Score: 53.24  E-value: 2.03e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 808688261  55 IVFVNCPNEQIARDIARAILDKKMASSVNILPKTSSLYFWKGEIEEGIEVSLV 107
Cdd:PRK10645  13 VVLCTAPDEATAQDLAAKVLAEKLAACVTLLPGATSLYYWEGKLEQEYEVQML 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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