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Conserved domains on  [gi|766944309|ref|NP_001292321|]
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orexin/Hypocretin receptor type 1 isoform 2 [Mus musculus]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
1-194 7.35e-95

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15208:

Pssm-ID: 475119 [Multi-domain]  Cd Length: 303  Bit Score: 280.04  E-value: 7.35e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309   1 MVPQAAVMECSSVLPeLANRTRLFSVCDEHWADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALV 80
Cdd:cd15208  130 MIPQAIVMECSRVVP-LANKTILLTVCDERWSDSIYQKVYHICFFLVTYLLPLCLMILAYFQIFRKLWCRQIPGTSSVVQ 208
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  81 RNWkrpseqleaqhqglctePQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFrqASDREA 160
Cdd:cd15208  209 RKW-----------------NKPRKSAVAAEEKQLRSRRKTAKMLIVVVIMFAICYLPVHLLNILRYVFGLF--TVDRET 269
                        170       180       190
                 ....*....|....*....|....*....|....
gi 766944309 161 VYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15208  270 IYAWFLFSHWLVYANSAINPIIYNFMSGKFREEF 303
 
Name Accession Description Interval E-value
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
1-194 7.35e-95

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 280.04  E-value: 7.35e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309   1 MVPQAAVMECSSVLPeLANRTRLFSVCDEHWADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALV 80
Cdd:cd15208  130 MIPQAIVMECSRVVP-LANKTILLTVCDERWSDSIYQKVYHICFFLVTYLLPLCLMILAYFQIFRKLWCRQIPGTSSVVQ 208
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  81 RNWkrpseqleaqhqglctePQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFrqASDREA 160
Cdd:cd15208  209 RKW-----------------NKPRKSAVAAEEKQLRSRRKTAKMLIVVVIMFAICYLPVHLLNILRYVFGLF--TVDRET 269
                        170       180       190
                 ....*....|....*....|....*....|....
gi 766944309 161 VYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15208  270 IYAWFLFSHWLVYANSAINPIIYNFMSGKFREEF 303
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
26-183 3.00e-19

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 83.50  E-value: 3.00e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309   26 VCDEHW-ADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWgrqipgttsalvrnwkrpseqleaqhqglctepqpR 104
Cdd:pfam00001 136 VCFIDFpEDLSKPVSYTLLISVLGFLLPLLVILVCYTLIIRTLR-----------------------------------K 180
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 766944309  105 ARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLkRVFgmFRQASDREAVYACFTFSHWLVYANSAANPIIY 183
Cdd:pfam00001 181 SASKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLL-DSL--ALDCELSRLLDKALSVTLWLAYVNSCLNPIIY 256
 
Name Accession Description Interval E-value
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
1-194 7.35e-95

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 280.04  E-value: 7.35e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309   1 MVPQAAVMECSSVLPeLANRTRLFSVCDEHWADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALV 80
Cdd:cd15208  130 MIPQAIVMECSRVVP-LANKTILLTVCDERWSDSIYQKVYHICFFLVTYLLPLCLMILAYFQIFRKLWCRQIPGTSSVVQ 208
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  81 RNWkrpseqleaqhqglctePQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFrqASDREA 160
Cdd:cd15208  209 RKW-----------------NKPRKSAVAAEEKQLRSRRKTAKMLIVVVIMFAICYLPVHLLNILRYVFGLF--TVDRET 269
                        170       180       190
                 ....*....|....*....|....*....|....
gi 766944309 161 VYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15208  270 IYAWFLFSHWLVYANSAINPIIYNFMSGKFREEF 303
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
1-194 2.13e-41

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 143.12  E-value: 2.13e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309   1 MVPQAAVMECSSvLPELANRTRLFSVCDEHWADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALV 80
Cdd:cd14993  132 MLPLLVVYELEE-IISSEPGTITIYICTEDWPSPELRKAYNVALFVVLYVLPLLIISVAYSLIGRRLWRRKPPGDRGSAN 210
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  81 RNWKRpseqleaqhqglctepqpraraflaevKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDrEA 160
Cdd:cd14993  211 STSSR---------------------------RILRSKKKVARMLIVVVVLFALSWLPYYVLSILLDFGPLSSEESD-EN 262
                        170       180       190
                 ....*....|....*....|....*....|....
gi 766944309 161 VYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd14993  263 FLLILPFAQLLGYSNSAINPIIYCFMSKKFRRGF 296
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
1-194 1.03e-36

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 130.82  E-value: 1.03e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309   1 MVPQAAVMEcssVLPELANRTRLFSVCDEHWADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAlv 80
Cdd:cd15207  130 MIPQALVLE---VKEYQFFRGQTVHICVEFWPSDEYRKAYTTSLFVLCYVAPLLIIAVLYVRIGYRLWFKPVPGGGSA-- 204
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  81 rnwkrpseqleaqhqglctePQPRARAflaevkQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKrVFGMFrQASDREA 160
Cdd:cd15207  205 --------------------SREAQAA------VSKKKVRVIKMLIVVVVLFALSWLPLHTVTMLD-DFGNL-SPNQREV 256
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 766944309 161 VYA-CFTFSHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15207  257 LYVyIYPIAHWLAYFNSCVNPIVYGYFNRNFRKGF 291
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
26-187 1.81e-24

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 98.13  E-value: 1.81e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  26 VCDEHWADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRnwkrpseqleaqhqglctepqpra 105
Cdd:cd00637  147 CCCLCWPDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNS------------------------ 202
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 106 raflAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASdreavYACFTFSHWLVYANSAANPIIYNF 185
Cdd:cd00637  203 ----SRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLLDVFGPDPSPLP-----RILYFLALLLAYLNSAINPIIYAF 273

                 ..
gi 766944309 186 LS 187
Cdd:cd00637  274 FN 275
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
27-194 6.25e-24

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 96.97  E-value: 6.25e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  27 CDEHWADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGttsalvrnwkrpseqlEAQHQGLctepqprar 106
Cdd:cd15095  153 CREVWPSKAFQKAYMIYTVLLTYVIPLAIIAVCYGLILRRLWRRSVDG----------------NNQSEQL--------- 207
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 107 aflaEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQAsdrEAVYACFTFSHWLVYANSAANPIIYNFL 186
Cdd:cd15095  208 ----SERALRQKRKVTRMVIVVVVLFAICWLPNHVLNLWQRFDPNFPET---YATYALKIAALCLSYANSAVNPFVYAFM 280

                 ....*...
gi 766944309 187 SGKFREQF 194
Cdd:cd15095  281 GENFRKYF 288
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
24-191 9.13e-23

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 93.73  E-value: 9.13e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  24 FSVCDEHWADELYPKIYHSCF-FIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTsalvrnwkrpseqleaqHQGLctepq 102
Cdd:cd15391  149 RVLCGESWPGPDTSRSAYTVFvMLLTYIIPLLILTSTYGYVGFRLWNRTAPGNA-----------------DKGR----- 206
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 103 praraflaEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFR---QASDREAVYACftfsHWLVYANSAAN 179
Cdd:cd15391  207 --------DDMQIKSKRKVIKMLVFVVLMFGICWLPLHLFNLVQDFSTVFRnmpQHTTRLIYGAC----HWIAMSNSFVN 274
                        170
                 ....*....|..
gi 766944309 180 PIIYNFLSGKFR 191
Cdd:cd15391  275 PIIYLFMNDSFR 286
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
25-194 1.84e-22

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 92.74  E-value: 1.84e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  25 SVCDEHWADELYPK---IYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGttsalvrnwkrpsEQLEAQHQglctep 101
Cdd:cd15390  151 TVCFIAWPDGPNSLqdfVYNIVLFVVTYFLPLIIMAVAYTRVGVELWGSKTIG-------------ENTPRQLE------ 211
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 102 qpraraflaevkQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFtfsHWLVYANSAANPI 181
Cdd:cd15390  212 ------------SVRAKRKVVKMMIVVVVIFAICWLPYHLYFILTYLYPDINSWKYIQQIYLAI---YWLAMSNSMYNPI 276
                        170
                 ....*....|...
gi 766944309 182 IYNFLSGKFREQF 194
Cdd:cd15390  277 IYCWMNKRFRYGF 289
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
26-194 4.43e-22

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 92.11  E-value: 4.43e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  26 VCDEHW-ADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGttsalvrnwkrpsEQLEAQhqglctepqpr 104
Cdd:cd14992  155 CCQIPPvDNKTYEKVYFLLIFVVIFVLPLIVMTLAYARISRELWFRKVPG-------------FSIKEV----------- 210
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 105 araflaEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYAcftFSHWLVYANSAANPIIYN 184
Cdd:cd14992  211 ------ERKRLKCKRRVIKMLVCVVVLFVICWLPFHLFFLLRDFFPLIMKEKHTLQVYY---FLHWIAMSNSMYNPIIYV 281
                        170
                 ....*....|
gi 766944309 185 FLSGKFREQF 194
Cdd:cd14992  282 TLNNNFRKNF 291
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
25-194 2.02e-21

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 90.11  E-value: 2.02e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  25 SVCDEHWADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAlvrnwKRpseqleaqhqglctepqpr 104
Cdd:cd15392  151 YICTESWPSDTNRYIYSLVLMILQYFVPLAVLVFTYTRIGIVVWAKRTPGEAEN-----NR------------------- 206
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 105 araflaEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFtfsHWLVYANSAANPIIYN 184
Cdd:cd15392  207 ------DQRMAESKRKLVKMMITVVAIFALCWLPLNILNLVGDHDESIYSWPYIPYLWLAA---HWLAMSHCCYNPFIYC 277
                        170
                 ....*....|
gi 766944309 185 FLSGKFREQF 194
Cdd:cd15392  278 WMNAKFRNGF 287
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
19-194 4.33e-20

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 86.69  E-value: 4.33e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  19 NRTRLFsvCDEHWADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTtsalvrnwkrpSEQLEAQHQGlc 98
Cdd:cd15393  148 NGVKPF--CLPVGPSDDWWKIYNLYLVCVQYFVPLVIICYAYTRIAVKIWGTKAPGN-----------AQDVRDDEIL-- 212
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  99 tepqpraraflaevkqmRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFgmfRQASDREAVYACFTFSHWLVYANSAA 178
Cdd:cd15393  213 -----------------KNKKKVIKMLIIVVALFALCWLPLQTYNLLNEIK---PEINKYKYINIIWFCSHWLAMSNSCY 272
                        170
                 ....*....|....*.
gi 766944309 179 NPIIYNFLSGKFREQF 194
Cdd:cd15393  273 NPFIYGLYNEKFKREF 288
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
25-194 1.39e-19

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 85.35  E-value: 1.39e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  25 SVCDEHWADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRpseqleaqhqglctepqpr 104
Cdd:cd15203  152 YFCTESWPSSSSRLIYTISVLVLQFVIPLLIISFCYFRISLKLRKRVKKKRGKRTLSSRRR------------------- 212
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 105 araflaevKQMRAR-RKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQasDREAVYACFTFSHWLVYANSAANPIIY 183
Cdd:cd15203  213 --------RSELRRkRRTNRLLIAMVVVFAVCWLPLNLFNLLRDFEPLPQI--DGRHFYLIFLICHLIAMSSACVNPLLY 282
                        170
                 ....*....|.
gi 766944309 184 NFLSGKFREQF 194
Cdd:cd15203  283 GWLNDNFRKEF 293
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
25-194 1.46e-19

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 85.25  E-value: 1.46e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  25 SVCDEHWAD--ELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGttsalvrnwkrpsEQLEAQHQGlctepq 102
Cdd:cd15202  151 SLCLEDWPEraDLFWKYYDLALFILQYFLPLLVISFAYARVGIKLWASNMPG-------------DATTERYFA------ 211
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 103 praraflaevkQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFgMFRQASDREAVYACFtfsHWLVYANSAANPII 182
Cdd:cd15202  212 -----------LRRKKKKVIKMLMVVVVLFALCWLPFNIYVLLLSSK-PDYLIKTINAVYFAF---HWLAMSSTCYNPFI 276
                        170
                 ....*....|..
gi 766944309 183 YNFLSGKFREQF 194
Cdd:cd15202  277 YCWLNERFRIEF 288
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
26-183 3.00e-19

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 83.50  E-value: 3.00e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309   26 VCDEHW-ADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWgrqipgttsalvrnwkrpseqleaqhqglctepqpR 104
Cdd:pfam00001 136 VCFIDFpEDLSKPVSYTLLISVLGFLLPLLVILVCYTLIIRTLR-----------------------------------K 180
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 766944309  105 ARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLkRVFgmFRQASDREAVYACFTFSHWLVYANSAANPIIY 183
Cdd:pfam00001 181 SASKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLL-DSL--ALDCELSRLLDKALSVTLWLAYVNSCLNPIIY 256
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
25-194 4.97e-19

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 83.50  E-value: 4.97e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  25 SVCDEHWADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTtsalvrnwkRPSeqleaqhqglctepqpr 104
Cdd:cd15096  152 SYCTFLTEVGTAAQTFFTSFFLFSYLIPLTLICVLYMLMLRRLRRQKSPGG---------RRS----------------- 205
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 105 araflaeVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRvfgmFRQASDREAVYACFTFSHWLVYANSAANPIIYN 184
Cdd:cd15096  206 -------AESQRGKRRVTRLVVVVVVVFAICWLPIHIILLLKY----YGVLPETVLYVVIQILSNCLAYGNSCVNPILYA 274
                        170
                 ....*....|
gi 766944309 185 FLSGKFREQF 194
Cdd:cd15096  275 FLSQNFRKAF 284
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
25-194 5.91e-19

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 83.28  E-value: 5.91e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  25 SVCDEHWADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRnwkrpseqleaqhqglctepqpr 104
Cdd:cd14971  150 TVCSEAWPSRAHRRAFALCTFLFGYLLPLLLICVCYAAMLRHLWRVAVRPVLSEGSR----------------------- 206
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 105 araflaevkqmRARRKTAKMLMVVLLVFALCYLPISVLNVLKRvfgmFRQASDREAVYACFTFSHWLVYANSAANPIIYN 184
Cdd:cd14971  207 -----------RAKRKVTRLVLVVVVLFAACWGPIHAILLLVA----LGPFPLTYATYALRIWAHCLAYSNSAVNPVLYA 271
                        170
                 ....*....|
gi 766944309 185 FLSGKFREQF 194
Cdd:cd14971  272 FLSEHFRKAF 281
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
25-194 9.05e-17

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 77.46  E-value: 9.05e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  25 SVCDEHWADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWgrqipgttsALVRNWKRPSEqleaqhqglctepqpr 104
Cdd:cd15098  153 TFCWENWPEKQQKPVYVVCTFVFGYLLPLLLITFCYAKVLNHLH---------KKLKNMSKKSE---------------- 207
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 105 araflaevkqmRARRKTAKMLMVVLLVFALCYLPISVLNvLKRVFGMF--RQASdreavYACFTFSHWLVYANSAANPII 182
Cdd:cd15098  208 -----------RSKKKTAQTVLVVVVVFGISWLPHHIIH-LWVEFGDFplTQAS-----FVLRITAHCLAYANSCVNPII 270
                        170
                 ....*....|..
gi 766944309 183 YNFLSGKFREQF 194
Cdd:cd15098  271 YAFLSENFRKAY 282
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
19-194 9.38e-16

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 74.63  E-value: 9.38e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  19 NRTRLFSVCDEHwADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRqipgttsalvrnwkrPSEQLEAQHQglc 98
Cdd:cd14997  148 NDGTPVAVCRTP-ADTFWKVAYILSTIVVFFVVPLAILSGLYSVICRRLVGH---------------PALESRRADA--- 208
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  99 tepqpraraflAEVKQMRARRKTAKMLMVVLLVFALCYLPIsvlnvlkRVFGMF--------RQASDREAVYACFTFSHW 170
Cdd:cd14997  209 -----------ANRHTLRSRRQVVYMLITVVVLFFVCLLPF-------RVVTLWiifapdedLQALGLEGYLNLLVFCRV 270
                        170       180
                 ....*....|....*....|....
gi 766944309 171 LVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd14997  271 MVYLNSALNPILYNLMSTKFRSAF 294
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
40-194 9.65e-16

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 74.58  E-value: 9.65e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  40 YHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSalvrnwkrpseqlEAQHQglctepqpraraflaevkQMRARR 119
Cdd:cd16003  162 YHIIVIVLVYCLPLLVMGITYTIVGITLWGGEIPGDTS-------------DKYHE------------------QLRAKR 210
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 766944309 120 KTAKMLMVVLLVFALCYLPISVLNVLKrvfGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd16003  211 KVVKMMIIVVLTFAICWLPYHIYFIVT---GLYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGF 282
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
19-194 1.07e-15

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 74.54  E-value: 1.07e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  19 NRTRLFSVCDEHWADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSeqleaqhqglc 98
Cdd:cd15980  153 NKTSPVYWCREDWPNQEMRKIYTTVLFANIYLAPLSLIVIMYARIGITLFKTAMPHTGKHNQEQRHVVS----------- 221
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  99 tepqpraraflaevkqmRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYaCFTFSHWLVYANSAA 178
Cdd:cd15980  222 -----------------RKKQKVIKMLLIVALLFILSWLPLWTLMMLSDYANLSPNQLQIINIY-IYPFAHWLAFFNSSV 283
                        170
                 ....*....|....*.
gi 766944309 179 NPIIYNFLSGKFREQF 194
Cdd:cd15980  284 NPIIYGFFNENFRRGF 299
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
45-191 3.28e-15

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 73.14  E-value: 3.28e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  45 FIVTYLAPLGLMAMAYFQIFRKLWGRQipgttsalvrnwkrpseqleaqHQGLCTEPQPRAraflaevkQMRARRKTAKM 124
Cdd:cd15389  173 FILQYVLPLLIIGVAYTRVAKKLWLRN----------------------AIGDVTTEQYVA--------QRRKKKKTIKM 222
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 766944309 125 LMVVLLVFALCYLPISVLNVLKRvFGMFRQASdreAVYACFtfsHWLVYANSAANPIIYNFLSGKFR 191
Cdd:cd15389  223 LMLVVLLFAICWLPLNCYHVLLS-SHPIRSNS---ALFFAF---HWLAMSSTCYNPFIYCWLNDSFR 282
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
24-193 3.33e-15

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 72.85  E-value: 3.33e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  24 FSVCDEHWADELYPKIYHSCFF-IVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRpseqleaqhqglctepq 102
Cdd:cd15394  148 FSICEEFWFGQEKQRLAYACSTlLITYVLPLLAISLSYLRISVKLRNRVVPGSMTQSQAEWDR----------------- 210
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 103 praraflaevkqmRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFrqaSDREAVYACFTFSHWLVYANSAANPII 182
Cdd:cd15394  211 -------------ARRRKTFRLLVVVVVAFAICWLPLHIFNVIRDIDIDL---IDKQYFNLIQLLCHWLAMSSACYNPFL 274
                        170
                 ....*....|.
gi 766944309 183 YNFLSGKFREQ 193
Cdd:cd15394  275 YAWLHDSFRGE 285
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
19-194 3.98e-15

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 72.93  E-value: 3.98e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  19 NRTRLFSVCDEHWADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWgrqipgTTSALVRNwKRPSEQleaqhqglc 98
Cdd:cd15981  152 NNSYPLYSCWEAWPDTEMRKIYTTVLFSHIYLAPLTLIVIMYARIAFKLF------KSSAPIRG-SQGEEE--------- 215
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  99 tePQPRARaflaevkqmRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYAcFTFSHWLVYANSAA 178
Cdd:cd15981  216 --EGRRVS---------KRKIKVINMLIIVALFFTLSWLPLWTLMLLTDYGHLSEDQLNLVTVYV-FPFAHWLAFFNSSV 283
                        170
                 ....*....|....*.
gi 766944309 179 NPIIYNFLSGKFREQF 194
Cdd:cd15981  284 NPIIYGYFNENFRRGF 299
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
24-194 1.59e-14

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 71.14  E-value: 1.59e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  24 FSVC---DEHWaDELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLW--GRQIPGttsalvrnwkrpseqLEAQHQglc 98
Cdd:cd15927  152 IQICypyPQEL-GPNYPKIMVLLRFLVYYLIPLLIIGVFYVLMARHLIrsTRNIGS---------------GQNQAA--- 212
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  99 tepqpraraflaeVKQMRARRKTAKMLMVVLLVFALCYLPISVLNvLKRVFgmfrqasdreAVYACFTFSHW-------- 170
Cdd:cd15927  213 -------------QRQIEARKKVAKTVLAFVVLFAVCWLPRHVFM-LWFHF----------APNGLVDYNAFwhvlkivg 268
                        170       180
                 ....*....|....*....|....*.
gi 766944309 171 --LVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15927  269 fcLSFINSCVNPVALYLLSGSFRRHF 294
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
27-194 7.09e-14

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 69.42  E-value: 7.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  27 CDEHWADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRpseqleaqhqglctepqprar 106
Cdd:cd15205  156 CLERWYSPTQQKIYTTFILVILFLLPLTTMLFLYSRIGYELWIKKRVGDASVLQTIHGI--------------------- 214
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 107 aflAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLkRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFL 186
Cdd:cd15205  215 ---EMSKISRKKKRAVKMMVTVVLLFAVCWAPFHVVHMM-IEYSNLENKYDGVTIKLIFAIVQLIGFSNSFNNPIVYAFM 290

                 ....*...
gi 766944309 187 SGKFREQF 194
Cdd:cd15205  291 NENFKKNF 298
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
45-194 1.07e-12

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 65.74  E-value: 1.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  45 FIVTYLAPLGLMAMAYFQIFRklwgrqipgttsaLVRNwkrpseQLeaqHQGLCTEPQPRARAFLaevkqmRARRKTAKM 124
Cdd:cd14968  170 FFACVLVPLLIMLVIYLRIFR-------------VIRK------QL---RQIESLLRSRRSRSTL------QKEVKAAKS 221
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 125 LMVVLLVFALCYLPISVLNVLKRVFGMFRqaSDREAVYACFTFSHwlvyANSAANPIIYNFLSGKFREQF 194
Cdd:cd14968  222 LAIILFLFALCWLPLHIINCITLFCPECK--VPKILTYIAILLSH----ANSAVNPIVYAYRIRKFRQTF 285
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
13-194 1.44e-12

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 65.56  E-value: 1.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  13 VLPELANRTRLFSVCDEHWADElyPKIYHSCFFIVT----YLAPLGLMAMAYFQIFRKLwgrqipgTTSALVRNWKRpse 88
Cdd:cd15093  136 VFAGTRENQDGSSACNMQWPEP--AAAWSAGFIIYTfvlgFLLPLLIICLCYLLIVIKV-------KSAGLRAGWQQ--- 203
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  89 qleaqhqglctepqpraraflaevkQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKrvfgMFRQASDREAVYACFTFS 168
Cdd:cd15093  204 -------------------------RKRSERKVTRMVVMVVVVFVICWLPFYVLQLVN----VFVQLPETPALVGVYHFV 254
                        170       180
                 ....*....|....*....|....*.
gi 766944309 169 HWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15093  255 VILSYANSCANPILYGFLSDNFKKSF 280
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
119-194 1.56e-12

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 65.28  E-value: 1.56e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 766944309 119 RKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQAsdreavYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd14967  190 LKAAKTLAIIVGAFLLCWLPFFIIYLVSAFCPPDCVP------PILYAVFFWLGYLNSALNPIIYALFNRDFRRAF 259
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
26-194 3.49e-12

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 64.46  E-value: 3.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  26 VCDEHWADELYpKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWgrqipgttsalvrnwkRPSEQLEAQHQglctepqpra 105
Cdd:cd15097  150 VCMPGWEEARR-KAMDTCTFAFGYLIPVLVVSLSYTRTIKYLW----------------TAVDPLEAMSE---------- 202
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 106 raflaevkQMRARRKTAKMLMVVLLVFALCYLPISVLnVLKRVFGMFrqaSDREAVYACFTFSHWLVYANSAANPIIYNF 185
Cdd:cd15097  203 --------SKRAKRKVTKMIIIVTALFCLCWLPHHVV-ILCYLYGDF---PFNQATYAFRLLSHCMAYANSCLNPIVYAL 270

                 ....*....
gi 766944309 186 LSGKFREQF 194
Cdd:cd15097  271 VSKHFRKGF 279
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
118-194 7.82e-12

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 63.06  E-value: 7.82e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 766944309 118 RRKTAKMLMVVLLVFALCYLPISVLNVLKRvFGMFrQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15001  192 RKQVIKMLISVVVLFAVCWGPLLIDNLLVS-FDVI-STLHTQALKYMRIAFHLLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
26-194 1.10e-11

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 62.96  E-value: 1.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  26 VCDEHWAD---ELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSalvrnwKRPSEQLEaqhqglctepq 102
Cdd:cd16002  147 VCYVEWPEheeRKYETVYHVCVTVLIYFLPLLVIGCAYTVVGITLWASEIPGDSS------DRYHEQVS----------- 209
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 103 praraflaevkqmrARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTfshWLVYANSAANPII 182
Cdd:cd16002  210 --------------AKRKVVKMMIVVVCTFAICWLPYHIYFLLQYFHPELYEQKFIQQVYLAIM---WLAMSSTMYNPII 272
                        170
                 ....*....|..
gi 766944309 183 YNFLSGKFREQF 194
Cdd:cd16002  273 YCCLNDRFRVGF 284
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
45-194 1.66e-11

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 62.76  E-value: 1.66e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  45 FIVTYLAPLGLMAMAYFQIFRKLWGRqipgttsalvRNWKrpsEQLEAQHQGLCTEPQpraraflaevkQMRARRKTAKM 124
Cdd:cd14979  176 TFIFFVLPMFVISILYFRIGVKLRSM----------RNIK---KGTRAQGTRNVELSL-----------SQQARRQVVKM 231
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 125 LMVVLLVFALCYLPISVLNVLKRVFGMFrQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd14979  232 LGAVVIAFFVCWLPFHAQRLMFSYASKE-DTFLFDFYQYLYPISGILFYLSSAINPILYNLMSSRFRVAF 300
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
116-194 2.76e-11

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 61.93  E-value: 2.76e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 766944309 116 RARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMfrqaSDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd14970  208 RARRKVTRLVLVVVAVFVVCWLPFHVFQIVRLLIDP----PETLTVVGVFLFCIALSYANSCLNPILYAFLDENFRKSF 282
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
44-194 5.16e-11

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 61.17  E-value: 5.16e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  44 FFIvtylaPLGLMAMAYFQIFRKLWgrqipgttsalvrnwKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAK 123
Cdd:cd15048  172 FFI-----PFISVSFFNLLIYLNIR---------------KRSRRRPLRSVPILPASQNPSRARSQREQVKLRRDRKAAK 231
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 766944309 124 MLMVVLLVFALCYLPISVLNVlkrvfgMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15048  232 SLAILVLVFLICWAPYTILTI------IRSFCSGSCVDSYLYEFTFWLLWTNSAINPFLYAACHPRFRKAF 296
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
25-194 7.00e-11

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 60.63  E-value: 7.00e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  25 SVCDEHWADELYPK---IYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAlvrnwkrpseqlEAQHQglctep 101
Cdd:cd16004  146 TKCIVAWPGDSGGKhqlTYHLAVIVLIYLLPLAVMFVTYSIIGITLWRSAVPGHQAH------------GAYHR------ 207
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 102 qpraraflaevkQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVY-ACFtfshWLVYANSAANP 180
Cdd:cd16004  208 ------------QLQAKKKFVKTMVVVVVTFAICWLPYHLYFILGSFNEDIYCQKYIQQVYlAIF----WLAMSSTMYNP 271
                        170
                 ....*....|....
gi 766944309 181 IIYNFLSGKFREQF 194
Cdd:cd16004  272 IIYCCLNQRFRSGF 285
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
119-194 7.72e-11

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 60.45  E-value: 7.72e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 766944309 119 RKTAKMLMVVLLVFALCYLPISVLNVLKrVFGMFRQASDREAVYACFTfshWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15067  191 QKAAKTLGIVMGVFILCWLPFFVTNILI-GFCPSNCVSNPDILFPLVT---WLGYINSGMNPIIYACSSRDFRRAF 262
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
113-194 8.68e-11

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 60.59  E-value: 8.68e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 113 KQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMfrqaSDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFRE 192
Cdd:cd15974  200 KRRKSERKVTRMVVIIVVVFVFCWLPFYMLNIVNLIVIL----PEEPAFVGVYFFVVVLSYANSCANPILYGFLSDNFKQ 275

                 ..
gi 766944309 193 QF 194
Cdd:cd15974  276 SF 277
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
27-194 1.05e-10

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 60.47  E-value: 1.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  27 CDEHWADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRnwkrpseqlEAQHQGLCTEPQPRAR 106
Cdd:cd14986  149 CWSSFYTPWQRKVYITWLATYVFVIPLIILSYCYGRILRTIWIRSRQKTDRPIAP---------TAMSCRSVSCVSSRVS 219
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 107 AFlaevkqMRARRKTAKMLMVVLLVFALCYLPISVLNvLKRVFGMFRQasDREAVYacfTFSHWLVYANSAANPIIYNFL 186
Cdd:cd14986  220 LI------SRAKIKTIKMTLVIILAFILCWTPYFIVQ-LLDVYAGMQQ--LENDAY---VVSETLASLNSALNPLIYGFF 287

                 ....*...
gi 766944309 187 SGKFREQF 194
Cdd:cd14986  288 SSHLSFEH 295
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
26-193 3.16e-10

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 58.98  E-value: 3.16e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  26 VCDEHWADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQipgttsalvRNWKRPSEqleaqhqglctepqpra 105
Cdd:cd15397  159 VCTESWPSEHHKLAYTTWLLLFQYCLPLLFILVCYLRIYLRLRRRK---------DMLERRGE----------------- 212
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 106 raflAEVKQMRARRKTAkMLMVVLLVFALCYLPISVLNVLkrvfgmfrQASDREAVYAC-----FTFSHWLVYANSAANP 180
Cdd:cd15397  213 ----YNRRAGHSKRINV-MLVSLVAAFALCWLPLNVFNAI--------ADWNHEAIPHCqhnliFSLCHLAAMASTCVNP 279
                        170
                 ....*....|...
gi 766944309 181 IIYNFLSGKFREQ 193
Cdd:cd15397  280 IIYGFLNSNFKKE 292
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
113-194 5.59e-10

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 57.93  E-value: 5.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 113 KQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKrvfgMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFRE 192
Cdd:cd15971  202 KRKKSEKKVTRMVSIVVAVFVFCWLPFYIFNVSS----VSVSISPTPGLKGMFDFVVVLSYANSCANPILYAFLSDNFKK 277

                 ..
gi 766944309 193 QF 194
Cdd:cd15971  278 SF 279
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
118-194 6.33e-10

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 57.78  E-value: 6.33e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 766944309 118 RRKTAKMLMVVLLVFALCYLPISVLnvlkRVFGMFRQASDREAVYacFTFSHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd14995  199 RKQVTKMLAVVVVLFALLWMPYRTL----VVYNSFASPPYLDLWF--LLFCRTCIYLNSAINPILYNLMSQKFRAAF 269
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
27-194 7.35e-10

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 57.79  E-value: 7.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  27 CDEHWADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWgrqipgttsalvrnwkrpseqleaqhqglctepqprar 106
Cdd:cd15206  152 CREVWPNEIAEQAWYVFLDLMLLVIPGLVMSVAYGLISWTLL-------------------------------------- 193
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 107 aflaevkqmRARRKTAKMLMVVLLVFALCYLPISVLNVLKrvfgMFRQASDREAV-YACFTFSHWLVYANSAANPIIYNF 185
Cdd:cd15206  194 ---------EAKKRVIRMLFVIVVEFFICWTPLYVINTWK----AFDPPSAARYVsSTTISLIQLLAYISSCVNPITYCF 260

                 ....*....
gi 766944309 186 LSGKFREQF 194
Cdd:cd15206  261 MNKRFRQAF 269
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
113-194 7.47e-10

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 57.74  E-value: 7.47e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 113 KQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVfGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFRE 192
Cdd:cd15053  183 RALRREKKATKTLAIVLGVFLFCWLPFFTLNILNAI-CPKLQNQSCHVGPALFSLTTWLGYVNSFLNPIIYTIFNIEFRK 261

                 ..
gi 766944309 193 QF 194
Cdd:cd15053  262 AF 263
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
44-194 7.98e-10

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 57.82  E-value: 7.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  44 FFIvtylaPLGLMAMAYFQIFRkLWGRQIpgttsalvrnwkrpsEQLEAQHQGL--CTEPQPRARAflaevkQMRARRKT 121
Cdd:cd15057  176 FYI-----PVAIMIVTYTRIYR-IARRQI---------------RRIAALERAAqeSTNPDSSLRS------SLRRETKA 228
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 766944309 122 AKMLMVVLLVFALCYLPISVLNVLKRvFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFlSGKFREQF 194
Cdd:cd15057  229 LKTLSIIMGVFVCCWLPFFILNCVLP-FCDLRTAQFPCVPDTTFIVFVWLGWANSSLNPIIYAF-NADFRKAF 299
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
113-194 9.81e-10

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 57.50  E-value: 9.81e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 113 KQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMfrqaSDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFRE 192
Cdd:cd15972  202 KRRGSERKVTRMVVIVVAAFVLCWLPFYALNIVNLVCPL----PEEPSLFGLYFFVVVLSYANSCANPIIYGFLSDNFKQ 277

                 ..
gi 766944309 193 QF 194
Cdd:cd15972  278 GF 279
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
19-194 1.18e-09

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 57.24  E-value: 1.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  19 NRTRLFSVCDEHWADELYPKIYHSCF-FIVTYLAPLGLMAMAYFQIFRKLWgrqipgtTSALvrnwkrpseqleaqhqGL 97
Cdd:cd15123  148 EKNTTFEACAPYPVSEKILQEIHSLLcFLVFYIIPLSIISVYYFLIARTLY-------KSTF----------------NM 204
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  98 CTEPQPRARaflaevKQMRARRKTAKMLMVVLLVFALCYLPISVLnVLKRVFgMFRQASDREAVYACFT-FSHWLVYANS 176
Cdd:cd15123  205 PAEEHSHAR------KQIESRKRVAKTVLVLVALFAFCWLPNHIL-YLYRSF-TYHTSVDSSAFHLIATiFSRVLAFSNS 276
                        170
                 ....*....|....*...
gi 766944309 177 AANPIIYNFLSGKFREQF 194
Cdd:cd15123  277 CVNPFALYWLSKSFRQHF 294
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
7-194 1.52e-09

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 56.65  E-value: 1.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309   7 VMECSSVLPELANRT------RLFSVCDEHWADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRqipGTTSALV 80
Cdd:cd15002  126 VPACLLPLPQWLFRTvkqsegVYLCILCIPPLAHEFMSAFVKLYPLFVFCLPLTFALFYFWRAYGQCQRR---GTKTQNL 202
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  81 RNwkrpseqleaqhqglctepqpraraflaevkQMRARRKTaKMLMVVLLVFALCYLPISVLnvlkrVFGMFRQASDREA 160
Cdd:cd15002  203 RN-------------------------------QIRSRKLT-HMLLSVVLAFTILWLPEWVA-----WLWLIHIKSSGSS 245
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 766944309 161 VYACFT-FSHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15002  246 PPQLFNvLAQLLAFSISSVNPIIFLLMSEEFREGF 280
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
27-189 2.75e-09

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 56.28  E-value: 2.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  27 CDEHWADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWgrqipgttsalvrnwKRPSEQLEAQHQGLctePQPRAR 106
Cdd:cd15197  149 CWILWPEPWYWKVYMTIVAFLVFFIPATIISICYIIIVRTIW---------------KKSKIQVTINKAGL---HDGSSR 210
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 107 AFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKrVFGMFRQASDREAVYacfTFSHWLVYANSAANPIIYNFL 186
Cdd:cd15197  211 RSSSRGIIPRAKIKTIKMTFVIVTVFIICWSPYFVFDLLD-VFGLLPRSKTKIAAA---TFIQSLAPLNSAINPLIYCLF 286

                 ...
gi 766944309 187 SGK 189
Cdd:cd15197  287 STH 289
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
2-194 2.80e-09

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 56.11  E-value: 2.80e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309   2 VPQAAVMECSSVLPeLANRTrlFSVCDEH-WADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLW--GRQIPGTTSa 78
Cdd:cd15125  133 VPEAVFSEVAHIMP-DDNTT--FTACIPYpQTDEMHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIksAHNIPGEYS- 208
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  79 lvrnwkrpseqleaQHQGlctepqpraraflaevKQMRARRKTAKMLMVVLLVFALCYLPISVLnVLKRVFGmFRQASDR 158
Cdd:cd15125  209 --------------EHSK----------------RQMETRKRLAKIVLVFVGLFAFCWFPNHVL-YMYRSFN-YNEIDSS 256
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 766944309 159 EAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15125  257 LGHMIVTLVARVLSFCNSCVNPFALYLLSESFRRHF 292
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
49-191 3.03e-09

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 55.96  E-value: 3.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  49 YLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRnwkrpseqleaqhqglctepqpraraflaevkQMRARRKTAKMLMVV 128
Cdd:cd15928  176 FFVPMVCLSLLYGLIGRALWDRRQRSRTAGASR--------------------------------RDNNHRQTVRMLAVI 223
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 766944309 129 LLVFALCYLPISVlnvlKRVFGMFRQASDREAVY---ACFTFSHWLVYANSAANPIIYNFLSGKFR 191
Cdd:cd15928  224 VLAFVLCWLPFHV----GRVIFNHSRASTKHLHYvsqYFNLVSFVLFYLSAAINPILYNLMSKRYR 285
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
26-194 4.24e-09

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 55.60  E-value: 4.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  26 VCDEHWADE--LYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvRNWKRPSEQLEAQHQglctepqp 103
Cdd:cd15399  152 ACSEKWPNGtlNDGTIYSVSMLLIQYVLPLAIISYAYIRIWTKL-------------KNHVSPGGGNDHYHQ-------- 210
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 104 raraflaevkqmrARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFtfsHWLVYANSAANPIIY 183
Cdd:cd15399  211 -------------RRRKTTKMLVCVVVVFAVSWLPFHAFQLASDIDSKVLDLKEYKLIYTIF---HVIAMCSTFANPLLY 274
                        170
                 ....*....|.
gi 766944309 184 NFLSGKFREQF 194
Cdd:cd15399  275 GWMNNNYRTAF 285
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
40-192 4.47e-09

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 55.54  E-value: 4.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  40 YHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGttsalvrnwkrpSEQLEAQHQGlctepqpraraflaevkqmrarr 119
Cdd:cd15088  164 FTIYHFILGFAVPLVVITVCYILILHRLARGVAPG------------NQSHGSSRTK----------------------- 208
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 766944309 120 KTAKMLMVVLLVFALCYLPISVLNVLKrvFGMFRQASdreAVYACFTFSHWLVYANSAANPIIYNFLSGKFRE 192
Cdd:cd15088  209 RVTKMVILIVVVFIVCWLPFHVVQLVN--LAMNRPTL---AFEVAYFLSICLGYANSCLNPFVYILVSENFRK 276
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
26-192 6.05e-09

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 55.14  E-value: 6.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  26 VCDEHWADELYpKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAlvrnwkrpseqleaqhqglctepqpRA 105
Cdd:cd14999  151 ICLPTWSEESY-KVYLTLLFSTSIVIPGLVIGYLYIRLARKYWLSQAAASNSS-------------------------RK 204
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 106 RaflaevkqmRARRKTAKMLMVVLLVFALCYLPISVLNVLKrVFGMFRQASDREAVYACFtFSHWLVYANSAANPIIYNF 185
Cdd:cd14999  205 R---------LPKQKVLKMIFTIVLVFWACFLPFWIWQLLY-LYSPSLSLSPRTTTYVNY-LLTCLTYSNSCINPFLYTL 273

                 ....*..
gi 766944309 186 LSGKFRE 192
Cdd:cd14999  274 LTKNYKE 280
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
38-194 6.16e-09

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 54.95  E-value: 6.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  38 KIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWgrqipgttsalvRNWKRPSEQLEAQHQglctepqpraraflaEVKQMRA 117
Cdd:cd14978  173 KYYFWLYAIFVVLLPFILLLILNILLIRALR------------KSKKRRRLLRRRRRL---------------LSRSQRR 225
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 766944309 118 RRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGmfrQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd14978  226 ERRTTIMLIAVVIVFLICNLPAGILNILEAIFG---ESFLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
114-194 1.03e-08

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 54.35  E-value: 1.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 114 QMRARRKTAKMLMVVLLVFALCYLPISVLNVL--KRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFR 191
Cdd:cd15000  203 VVRYKKKAAKTLFIVLITFVVCRIPFTALIFYryKLVPNDNTQNSVSGSFHILWFASKYLMFLNAAVNPLIYGFTNENFR 282

                 ...
gi 766944309 192 EQF 194
Cdd:cd15000  283 KAF 285
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
109-194 1.11e-08

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 54.25  E-value: 1.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 109 LAEVKQMRARRKTAKMLMVVLLVFALCYLPISV---LNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF 185
Cdd:cd15168  196 LGEGVTSALRRKSIRLVIIVLALFAVCFLPFHVtrtINLAARLLSGTASCATLNGIYVAYKVTRPLASLNSCLNPLLYFL 275

                 ....*....
gi 766944309 186 LSGKFREQF 194
Cdd:cd15168  276 AGDKFRRRL 284
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
26-192 1.15e-08

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 54.45  E-value: 1.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  26 VCDEHWADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQipGTTSALVRNWKRPSEQleaqhqglctepqpra 105
Cdd:cd15396  159 VCIEAWPSETERLIFTTSLLVFQYFVPLGFIFICYLKIFVCLKKRN--SKIDRMRENESRLSEN---------------- 220
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 106 raflaevkqmrarRKTAKMLMVVLLVFALCYLPISVLNVlkrVFGMfrqasDREAVYAC-----FTFSHWLVYANSAANP 180
Cdd:cd15396  221 -------------KRINTMLISIVVTFAACWLPLNIFNV---VFDW-----NHEVLMSChhnlvFTLCHLVAMVSTCINP 279
                        170
                 ....*....|..
gi 766944309 181 IIYNFLSGKFRE 192
Cdd:cd15396  280 IFYGFLNKNFQK 291
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
44-194 1.20e-08

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 54.22  E-value: 1.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  44 FFIVTYLAPLGLMAMAYFQIFRKLWGRqipgttsalVRNWKRPSEQLEAQHQglctepqpraraflaevkqmRARRKTAK 123
Cdd:cd14972  160 LILVFFFIALVIIVFLYVRIFWCLWRH---------ANAIAARQEAAVPAQP--------------------STSRKLAK 210
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 766944309 124 MLMVVLLVFALCYLPISVLNVLkrVFGMFRQASDREAVYACFTFshwlVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd14972  211 TVVIVLGVFLVCWLPLLILLVL--DVLCPSVCDIQAVFYYFLVL----ALLNSAINPIIYAFRLKEMRRAV 275
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
116-198 2.39e-08

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 53.33  E-value: 2.39e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 116 RARRKTAKMLMVVLLVFALCYLPISVLnVLKRVFGmFRQASDREAVYACFTFShwLVYANSAANPIIYNFLSgkfrEQFK 195
Cdd:cd15092  205 RNLRRITRLVLVVVAVFVGCWTPIQIF-VLAQGLG-VQPSSETAVAILRFCTA--LGYVNSSLNPVLYAFLD----ENFK 276

                 ...
gi 766944309 196 AAF 198
Cdd:cd15092  277 ACF 279
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
116-194 2.54e-08

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 53.13  E-value: 2.54e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 766944309 116 RARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMfrqaSDREAVYACFTfshWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15312  218 KKERKAAKTLSIVMGVFLLCWLPFFVATLIDPFLNF----STPVDLFDALV---WLGYFNSTCNPLIYGFFYPWFQKAF 289
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
113-194 3.12e-08

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 52.99  E-value: 3.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 113 KQMRARRKTAKMLMVVLLVFALCYLPISVLNVLkrvfGMFRQASDREAVyacfTFSHWLVYANSAANPIIYNFLSGKFRE 192
Cdd:cd15970  203 QRKRSERKITLMVMMVVTVFVICWMPFYVVQLV----SVFVGQHDATVS----QLSVILGYANSCANPILYGFLSDNFKR 274

                 ..
gi 766944309 193 QF 194
Cdd:cd15970  275 SF 276
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
119-194 3.27e-08

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 52.66  E-value: 3.27e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 766944309 119 RKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTfshWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15329  188 RKAIKTLGIIMGAFTLCWLPFFILALLRPFLKPIKCSCIPLWLSRLFL---WLGYANSFLNPIIYAKFNREFRTPF 260
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
46-194 4.19e-08

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 52.84  E-value: 4.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  46 IVTYLAPLGLMAMAYFQIF----RKLwgRQIPGTTSALVRNWKRPSEQLEAQHQGlctepQPRARAFLAEVKQMRArrkt 121
Cdd:cd15058  172 VVSFYIPLLIMIFVYARVFliatRQL--QLIDKRRLRFQSECPAPQTTSPEGKRS-----SGRRPSRLTVVKEHKA---- 240
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 766944309 122 AKMLMVVLLVFALCYLPISVLNVLkRVFGmfRQASDREAvyacFTFSHWLVYANSAANPIIYnFLSGKFREQF 194
Cdd:cd15058  241 LKTLGIIMGTFTLCWLPFFIANII-NVFN--RNLPPGEV----FLLLNWLGYINSGLNPIIY-CRSPEFRTAF 305
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
7-194 4.53e-08

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 52.38  E-value: 4.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309   7 VMECSSVLPELANRTRLF------SVCDEHWADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalv 80
Cdd:cd14985  126 VVACLLSLPTFLLRSLQAienlnkTACIMLYPHEAWHFGLSLELNILGFVLPLLIILTCYFHIARSL------------- 192
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  81 rnwKRPSEQLEaqhqglctepqpraraflaevKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGM--FRQASDR 158
Cdd:cd14985  193 ---RKRYERTG---------------------KNGRKRRKSLKIIFALVVAFLVCWLPFHFFKFLDFLAQLgaIRPCFWE 248
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 766944309 159 EAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd14985  249 LFLDLGLPIATCLAFTNSCLNPFIYVFVDRRFRQKV 284
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
114-194 5.84e-08

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 52.15  E-value: 5.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 114 QMRARRKTAKMLMVVLLVFALCYLPISVLNVlkrvfgMFRQASD-REAVYACFTFSH----WLVYANSAANPIIYNFLSG 188
Cdd:cd15133  219 HPRTRAQVTKMLFILVVVFAICWAPFHIDRL------MWSFISDwTDNLHEVFQYVHiisgVFFYLSSAVNPILYNLMST 292

                 ....*.
gi 766944309 189 KFREQF 194
Cdd:cd15133  293 RFREMF 298
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
42-194 5.91e-08

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 52.11  E-value: 5.91e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  42 SCFFIV-----------TYLAPLGLMAMAYFQIFR--KLWGRQIpgttSALVRNWKRPSEQleAQHQGlctepqpraraf 108
Cdd:cd15056  158 SCVFMVnkpfaiicstvAFYIPALLMVLAYYRIYVaaREQAHQI----RSLQRAGSSNHEA--DQHRN------------ 219
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 109 laevKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMfrqasdrEAVYACFTFSHWLVYANSAANPIIYNFLSG 188
Cdd:cd15056  220 ----SRMRTETKAAKTLGIIMGCFCVCWAPFFVTNIVDPFIGY-------RVPYLLWTAFLWLGYINSGLNPFLYAFFNK 288

                 ....*.
gi 766944309 189 KFREQF 194
Cdd:cd15056  289 SFRRAF 294
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
46-194 6.12e-08

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 52.21  E-value: 6.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  46 IVTYLAPLGLMAMAYFQIFRKlwgrqipgttsalVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRaRRKTAKML 125
Cdd:cd15958  172 IISFYIPLLIMIFVYLRVYRE-------------AKKQIKKIDKCEGRFHNTLTGLGRKCKRRPSRILALR-EQKALKTL 237
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 766944309 126 MVVLLVFALCYLPISVLNVLkRVFgmFRQASDREAvyacFTFSHWLVYANSAANPIIYnFLSGKFREQF 194
Cdd:cd15958  238 GIIMGVFTLCWLPFFLVNVV-NVF--NRELVPDWL----FVFFNWLGYANSAFNPIIY-CRSPDFRKAF 298
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
104-194 6.44e-08

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 52.17  E-value: 6.44e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 104 RARAFLAEVKQMR-ARRKTAKMLMVVLLVFALCYLPISVLNVLKrvfgMFRQASDREAVYACFTFShwlvYANSAANPII 182
Cdd:cd15973  191 RAVALKAGWQQRRkSEKKITRMVLMVVTVFVICWMPFYVVQLLN----LFLPRLDATVNHASLILS----YANSCANPIL 262
                         90
                 ....*....|..
gi 766944309 183 YNFLSGKFREQF 194
Cdd:cd15973  263 YGFLSDNFRRSF 274
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
112-194 7.84e-08

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 51.79  E-value: 7.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 112 VKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLkRVFGmfRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFR 191
Cdd:cd15978  199 IKFLMAKKRVIRMLIVIVILFFLCWTPIFSANAW-RAFD--TRSADRLLSGAPISFIHLLSYTSACVNPIIYCFMNKRFR 275

                 ...
gi 766944309 192 EQF 194
Cdd:cd15978  276 MGF 278
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
31-194 7.96e-08

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 51.68  E-value: 7.96e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  31 WADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGttsalvrnwkrpseqleaqhqglctePQPRARafla 110
Cdd:cd14991  156 YTKPSLSIRWHNALFLLEFFLPLGLIVFCSVRIACNLRIRQSLG--------------------------KQARVQ---- 205
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 111 evkqmRARRktakMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKF 190
Cdd:cd14991  206 -----RAIR----LVFLVVIVFVLCFLPSIIAGLLALVFKNLGSCRCLNSVAQLFHISLAFTYLNSALDPVIYCFSSPWF 276

                 ....
gi 766944309 191 REQF 194
Cdd:cd14991  277 RNSL 280
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
113-194 1.10e-07

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 51.17  E-value: 1.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 113 KQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVfgmfrqaSDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFRE 192
Cdd:cd15049  188 RETARERKAARTLSAILLAFIITWTPYNILVLVSTF-------CAKCIPDTLWSFGYWLCYINSTINPFCYALCNKTFRK 260

                 ..
gi 766944309 193 QF 194
Cdd:cd15049  261 TF 262
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
117-194 1.23e-07

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 51.35  E-value: 1.23e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 766944309 117 ARRKTAKMLMVVLLVFALCYLPISVLNVLKrvfgMFRQASDREAVY-ACFTFSHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15979  201 AKKRVIRMLVVIVAMFFLCWLPIFSANTWR----AFDPLSAHRALSgAPISFIHLLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
114-194 1.32e-07

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 51.02  E-value: 1.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 114 QMRARRKTAKMLMVVLLVFALCYLPISVlnvlKRVFGMFRQASDrEAVYACFTFSHW----LVYANSAANPIIYNFLSGK 189
Cdd:cd15357  214 QRPSRKSVTKMLFVLVLVFAICWAPFHV----DRLFFSFVVEWT-EPLANVFNLIHVvsgvFFYLSSAVNPIIYNLLSRR 288

                 ....*
gi 766944309 190 FREQF 194
Cdd:cd15357  289 FRTAF 293
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
34-138 1.34e-07

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 51.12  E-value: 1.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  34 ELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAlvrnwkrpseqleaqhqglctepQPRARaflaevk 113
Cdd:cd15204  161 QAYYKAYYLFLFVLEFVLPVLIMTLCYLRIVRKVWFRRVPGQQTE-----------------------QIRRR------- 210
                         90       100
                 ....*....|....*....|....*
gi 766944309 114 qMRARRKTAKMLMVVLLVFALCYLP 138
Cdd:cd15204  211 -LRRRRRKVRLLVVILTAFVLCWAP 234
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
46-185 1.36e-07

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 51.35  E-value: 1.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  46 IVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSEqleaqhqglCTEPQPRARAflaevkqmRARRKTAKML 125
Cdd:cd15198  174 VVGFVAPVVILGVCYGRLLLKWWERANQAPGAKKPWKKPSKSH---------LRATAPSALP--------RAKVKTLKMT 236
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 126 MVVLLVFALCYLPISVLNvLKRVFGMFRQasDREAVYACFTFshwLVYANSAANPIIYNF 185
Cdd:cd15198  237 LVIALLFVGCSLPYFIAE-LAAAFGSGDW--EPEKVAAALGV---MAVANSATNPFVFLF 290
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
32-194 1.56e-07

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 51.05  E-value: 1.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  32 ADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLwgrqipgTTSALvrnwkrpseqleaqhqGLCTEPQPRARaflae 111
Cdd:cd15124  162 SNELHPKIHSMASFLIFYVIPLSIISVYYYFIAKNL-------IRSAY----------------NLPVEGNVHVR----- 213
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 112 vKQMRARRKTAKMLMVVLLVFALCYLPISVLnVLKRVFgMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFR 191
Cdd:cd15124  214 -RQIESRKRLAKTVLVFVGLFAFCWLPNHII-YLYRSY-HYSEVDTSMLHFVSSICARILAFTNSCVNPFALYLLSKSFR 290

                 ...
gi 766944309 192 EQF 194
Cdd:cd15124  291 KQF 293
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
26-194 1.59e-07

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 50.73  E-value: 1.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  26 VCDEHWADEL-YPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwKRPSEQLEAQHQglctepqpr 104
Cdd:cd14982  150 TCFEFLSEWLaSAAPIVLIALVVGFLIPLLIILVCYSLIIRAL----------------RRRSKQSQKSVR--------- 204
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 105 araflaevkqmraRRKTAKMLMVVLLVFALCYLPisvLNVLKRVFGMFRQA-----SDREAVYACFTFSHWLVYANSAAN 179
Cdd:cd14982  205 -------------KRKALRMILIVLAVFLVCFLP---YHVTRILYLLVRLSfiadcSARNSLYKAYRITLCLASLNSCLD 268
                        170
                 ....*....|....*
gi 766944309 180 PIIYNFLSGKFREQF 194
Cdd:cd14982  269 PLIYYFLSKTFRKRL 283
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
112-194 1.98e-07

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 50.39  E-value: 1.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 112 VKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDrEAVYACFTfshWLVYANSAANPIIYNFLSGKFR 191
Cdd:cd15052  184 IRLLSNEQKASKVLGIVFAVFVICWCPFFITNILTGLCEECNCRIS-PWLLSVFV---WLGYVSSTINPIIYTIFNKTFR 259

                 ...
gi 766944309 192 EQF 194
Cdd:cd15052  260 RAF 262
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
45-194 2.27e-07

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 50.32  E-value: 2.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  45 FIVTYLAPLGLMAMAYFQIFrklwgrqipgttsalvrnwkrpseqLEAQHQGLCTEPQP----RARAFLAevKQMRArrk 120
Cdd:cd15068  176 FFACVLVPLLLMLGVYLRIF-------------------------LAARRQLKQMESQPlpgeRARSTLQ--KEVHA--- 225
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 766944309 121 tAKMLMVVLLVFALCYLPISVLNvlkrVFGMFRQASDREA---VYACFTFSHwlvyANSAANPIIYNFLSGKFREQF 194
Cdd:cd15068  226 -AKSLAIIVGLFALCWLPLHIIN----CFTFFCPDCSHAPlwlMYLAIVLSH----TNSVVNPFIYAYRIREFRQTF 293
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
119-194 2.57e-07

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 49.97  E-value: 2.57e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 766944309 119 RKTAKMLMVVLLVFALCYLPISVLNVLKrvfGMFRQASDREAVYACFTfshWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15310  190 KKATQMLAIVLGAFIVCWLPFFLTHILN---THCQACHVPPELYSATT---WLGYVNSALNPVIYTTFNIEFRRAF 259
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
47-194 2.99e-07

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 50.29  E-value: 2.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  47 VTYLAPLGLMAMAYFQIF----------RKLWGRqIPGTTSALVRN----WKRPSEQLE-AQHQGLCTepqpraraflae 111
Cdd:cd15959  174 VSFYVPLLVMIFVYVRVFvvatrqvrliRKDKVR-FPPEESPPAESrpacGRRPSRLLAiKEHKALKT------------ 240
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 112 vkqmrarrktakmLMVVLLVFALCYLPISVLNVLKrVFGmfRQASDREAvyacFTFSHWLVYANSAANPIIYnFLSGKFR 191
Cdd:cd15959  241 -------------LGIIMGTFTLCWLPFFVANIIK-VFC--RSLVPDPA----FLFLNWLGYANSAFNPIIY-CRSPDFR 299

                 ...
gi 766944309 192 EQF 194
Cdd:cd15959  300 SAF 302
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
116-194 3.00e-07

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 50.17  E-value: 3.00e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 766944309 116 RARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAvyACFTFSHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15094  206 RSHRKVTRLVLTVISVYIICWLPYWAFQVHLIFLPPGTDMPKWEI--LMFLLLTVLSYANSMVNPLLYAFLSENFRKSF 282
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
110-194 3.47e-07

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 49.85  E-value: 3.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 110 AEVKQMRARRKTAKMLMVVLLVFALCYLPISVlnvlKRVfgMFRQASDREAVYACFTFSHW-------LVYANSAANPII 182
Cdd:cd15355  225 MEPGRVQSLRHGVLVLRAVVIAFVVCWLPYHV----RRL--MFCYVSDEQWTTFLYDFYHYfymltnvLFYVSSAINPIL 298
                         90
                 ....*....|..
gi 766944309 183 YNFLSGKFREQF 194
Cdd:cd15355  299 YNLVSANFRQIF 310
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
119-198 3.47e-07

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 49.63  E-value: 3.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 119 RKTAKMLMVVLLVFALCYLPISVLNVlkrVFGMFRQASDREAVYACFTfshWLVYANSAANPIIYNFlsgkFREQFKAAF 198
Cdd:cd15064  189 RKAAKTLGIILGAFIVCWLPFFLVAL---IVPLCSHCWIPLALKSFFL---WLGYFNSLINPLIYTF----FNKDFRKAF 258
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
120-194 4.17e-07

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 49.66  E-value: 4.17e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 766944309 120 KTAKMLMVVLLVFALCYLPISVLNVLkrvfgmfrQASDREAV-YACFTFSHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15065  233 KAAVTLGIIMGVFLICWLPFFIINII--------AAFCKTCIpPKCFKILTWLGYFNSCLNPIIYSIFNSEFRRAF 300
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
46-194 5.23e-07

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 49.25  E-value: 5.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  46 IVTYLAPLGLMAMAYFQIFR--KLWGRQIPGTTSALvrnwkrpseqleaqhqglctEPQPRARAFLAEvkqmraRRKTAK 123
Cdd:cd15051  170 IGTFYLPLLIMCGVYLRIFRiaREQAKRINALTPAS--------------------TANSSKSAATAR------EHKATV 223
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 766944309 124 MLMVVLLVFALCYLPISVLNVLKRvfgmFRQASDREAVYACFTfshWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15051  224 TLAAVLGAFIICWFPYFTYFTYRG----LCGDNINETALSVVL---WLGYANSALNPILYAFLNRDFRRAF 287
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
113-200 5.61e-07

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 49.18  E-value: 5.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 113 KQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAvyacFTFSHWLVYANSAANPIIYNFLSGKFRE 192
Cdd:cd15307  195 RIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECEERISHWV----FDVVTWLGYASSMVNPIFYTIFNKVFRQ 270

                 ....*...
gi 766944309 193 QFKAAFSC 200
Cdd:cd15307  271 AFKKVLLC 278
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
119-194 5.74e-07

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 48.90  E-value: 5.74e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 766944309 119 RKTAKMLMVVLLVFALCYLPISVLNVLKrvfgMFRQASDREAVYACFTfshWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15061  188 RKTAKTLAIVVGCFIVCWLPFFIMYLIE----PFCDCQFSEALSTAFT---WLGYFNSVINPFIYAFYNKDFRRAF 256
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
107-194 5.77e-07

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 49.32  E-value: 5.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 107 AFLAEVKQMRARRKTAK-----MLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDR--EAVYACFTFSHWLVYANSAAN 179
Cdd:cd15922  190 ASIAKMNSNNARGRAMKakslqMIGISLVIFIICFVPLHVTRTVGVVVKLFYPESCTllHKVEVAYYISWVLTGVNCCLD 269
                         90
                 ....*....|....*
gi 766944309 180 PIIYNFLSGKFREQF 194
Cdd:cd15922  270 PLLYCFASEKFRKSF 284
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
113-194 5.79e-07

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 49.38  E-value: 5.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 113 KQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRqasdrEAVYACFTFSHW----LVYANSAANPIIYNFLSG 188
Cdd:cd15358  225 QEKRRRRQVTKMLFVLVVVFGICWAPFHTDRLMWSFISQWT-----GELHLAFQYVHIisgvFFYLSSAANPVLYNLMST 299

                 ....*.
gi 766944309 189 KFREQF 194
Cdd:cd15358  300 RFREMF 305
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
115-194 7.04e-07

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 48.88  E-value: 7.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 115 MRARRKTAKMLMVVLLVFALCYLPISVLNVLKrvfgMFRQASDREAVYACFTfshWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15309  182 LQKEKKATQMLAIVLGVFIICWLPFFITHILN----MHCDCNIPPALYSAFT---WLGYVNSAVNPIIYTTFNIEFRKAF 254
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
115-185 7.41e-07

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 48.70  E-value: 7.41e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 766944309 115 MRARRKTAKMLMVVLLVFALCYLPISVLNVlkrvFGMFRQASDreAVYACFTfshWLVYANSAANPIIYNF 185
Cdd:cd15055  215 KKSERKAAKTLGIVVGVFLLCWLPYYIVSL----VDPYISTPS--SVFDVLI---WLGYFNSCLNPLIYAL 276
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
43-194 8.66e-07

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 48.74  E-value: 8.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  43 CFFIVTYLAPLGLMAMAYFQIFRKLwgRQIPGTTSALVRNWKRpseqleaqhqglctepqpraraflaeVKQMRARRKTA 122
Cdd:cd14969  167 SLFVFCFFLPLAIIIFCYYKIYRTL--RKMSKRAARRKNSAIT--------------------------KRTKKAEKKVA 218
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 766944309 123 KMLMVVLLVFALCYLPISVLNVLkRVFGMFRQASDREAVYAcftfshwLVYANSAA--NPIIYNFLSGKFREQF 194
Cdd:cd14969  219 KMVLVMIVAFLIAWTPYAVVSLY-VSFGGESTIPPLLATIP-------ALFAKSSTiyNPIIYVFMNKQFRRAL 284
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
45-194 1.28e-06

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 48.24  E-value: 1.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  45 FIVTYLAPLGLMAMAYFQIFRklwgrqipgttsaLVRNwkrpseQLEAQHQGLCtepqpRARAFlaevkqMRARRKTAKM 124
Cdd:cd15070  169 FFTWILIPLVIMCALYVDIFY-------------IIRN------KLSQNATGFR-----ETGAF------YGREFKTAKS 218
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 125 LMVVLLVFALCYLPISVLNVLKrvfgMFRQASDREAVYACFTFSHwlvyANSAANPIIYNFLSGKFREQF 194
Cdd:cd15070  219 LALVLFLFAVCWLPLSIINCVV----YFNPKVPKIALYLGILLSH----ANSMMNPIVYACKIKKFKETY 280
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
46-194 1.30e-06

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 48.41  E-value: 1.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  46 IVTYLAPLGLMAMAYFQIFRklwgrqIPGTTSALVRNWKRPSEQLEA-QHQGLCTEPQPRARAflaevkQMRARRKTAKM 124
Cdd:cd15319  178 LISFYIPVAIMIVTYTRIYR------IAQIQIRRISSLERAAEHAQScRSNRIDCHHHTSLRT------SIKKETKVLKT 245
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 766944309 125 LMVVLLVFALCYLPISVLNVLkrVFGMFRQASDREAVYAC-----FTFSHWLVYANSAANPIIYNFlSGKFREQF 194
Cdd:cd15319  246 LSVIMGVFVCCWLPFFILNCM--VPFCDRPPADPDAGLPCvsettFDVFVWFGWANSSLNPIIYAF-NADFRKVF 317
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
116-192 1.62e-06

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 47.82  E-value: 1.62e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 766944309 116 RARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFshWLVYANSAANPIIYNFLSGKFRE 192
Cdd:cd15012  201 EARRKVVRLLVAVVVSFALCNLPYHARKMWQYWSEPYRCDSNWNALLTPLTF--LVLYFNSAVNPLLYAFLSKRFRQ 275
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
116-198 2.01e-06

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 47.48  E-value: 2.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 116 RAR-RKTAKMLMVVLLVFALCYLPISVLNVLKRVFgmfrqasdREAVY---ACFTFSHWLVYANSAANPIIYNFlsgkFR 191
Cdd:cd15333  191 RAReRKATKTLGIILGAFIVCWLPFFIISLVLPIC--------KDACWfhlAIFDFFTWLGYLNSLINPIIYTM----SN 258

                 ....*..
gi 766944309 192 EQFKAAF 198
Cdd:cd15333  259 EDFKQAF 265
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
107-194 2.17e-06

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 47.50  E-value: 2.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 107 AFLAEVKQMRARRKT--AKMLMVVLLVFALCYLPISVLNvLKRVFGMFRQASDREAVYACFTF----SHWLVYANSAANP 180
Cdd:cd14976  198 RFLQRKRGGSKRRKSrvTKSVFIVVLSFFICWLPNQALS-LWSALIKFDDVPFSDAFFAFQTYafpvAICLAHSNSCLNP 276
                         90
                 ....*....|....
gi 766944309 181 IIYNFLSGKFREQF 194
Cdd:cd14976  277 VLYCLVRREFRDAL 290
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
122-194 2.26e-06

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 47.62  E-value: 2.26e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 766944309 122 AKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHwlvyANSAANPIIYNFLSGKFREQF 194
Cdd:cd15069  226 AKSLAIIVGIFALCWLPVHILNCITLFQPEFSKSKPKWAMNVAILLSH----ANSVVNPIVYAYRNRDFRYTF 294
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
116-194 2.41e-06

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 47.25  E-value: 2.41e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 766944309 116 RARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQasdREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15089  206 RNLRRITRMVLVVVAAFIICWTPIHIFVIVWTLVDIDRR---NPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCF 281
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
113-198 2.66e-06

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 47.13  E-value: 2.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 113 KQMRARrKTAKMLMVVLLVFALCYLPISVlnvlkrvFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFRE 192
Cdd:cd15295  189 KRLRDR-KLAKSLAIILGTFAICWAPYSL-------FTIIRAACEKHRGSPWYNFAFWLQWFNSFINPFLYPLCHKRFRK 260

                 ....*.
gi 766944309 193 QFKAAF 198
Cdd:cd15295  261 AFLKIF 266
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
119-192 2.98e-06

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 46.87  E-value: 2.98e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 766944309 119 RKTAKMLMVVLLVFALCYLPISVLNVlkrvfgmfrqASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFRE 192
Cdd:cd15210  189 RRLTRMMLVIFLCFLVCYLPITLVNV----------FDDEVAPPVLHIIAYVLIWLSSCINPIIYVAMNRQYRQ 252
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
116-194 3.07e-06

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 47.26  E-value: 3.07e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 766944309 116 RARRKTAKMLMVVLLVFALCYLPISVLnVLKRVFGmfrQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15091  208 RNLRRITRLVLVVVAVFVVCWTPIHIF-ILVEALG---SVSHSTAAVSSYYFCIALGYTNSSLNPILYAFLDENFKRCF 282
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
113-194 3.32e-06

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 46.94  E-value: 3.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 113 KQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKrVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFRE 192
Cdd:cd15134  218 RSSQSRRTVLRMLVAVVVAFFICWAPFHAQRLLT-VYAKNMTPPYLFINRILFYISGVLYYVSSTVNPILYNVMSAKYRQ 296

                 ..
gi 766944309 193 QF 194
Cdd:cd15134  297 AF 298
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
113-194 3.73e-06

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 46.74  E-value: 3.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 113 KQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFgmfrqASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFRE 192
Cdd:cd15301  194 RQKKQESKAAKTLSAILLAFIVTWTPYNVLVLIKAFF-----PCSDTIPTELWDFSYYLCYINSTINPLCYALCNAAFRR 268

                 ..
gi 766944309 193 QF 194
Cdd:cd15301  269 TY 270
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
116-191 4.34e-06

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 46.80  E-value: 4.34e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 766944309 116 RARRKTAKMLMVVLLVFALCYLPISVLNVLkrVFGMFRQASDREAVYA--CFTFSHWLVYANSAANPIIYNFLSGKFR 191
Cdd:cd15131  213 KNNRQTVKMLAVVVFAFVLCWLPFHVGRYL--FSKSFEAGSLEIALISqyCNLVSFVLFYLSAAINPILYNIMSKKYR 288
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
116-191 4.50e-06

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 46.71  E-value: 4.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 116 RARRKTAKMLMVVLLVFALCYLPISVLNVLkrvfgmFRQASDreavYACFTFSHW-------LVYANSAANPIIYNFLSG 188
Cdd:cd15132  214 RSHRQTVRILAVVVLAFIICWLPFHIGRIL------FANTED----YRTMMFSQYfnivamqLFYLSASINPILYNLISR 283

                 ...
gi 766944309 189 KFR 191
Cdd:cd15132  284 KYR 286
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
115-194 4.61e-06

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 46.57  E-value: 4.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 115 MRARRKTAkMLMVVLLVFALCYLPISVLNVLKrVFGMFRQASDreavyACFTFSHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15059  189 RKERRFTL-VLGVVMGAFVLCWLPFFFTYPLV-VVCKTCGVPE-----LLFKFFFWLGYCNSALNPVIYTIFNKDFRRAF 261
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
106-194 5.01e-06

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 46.42  E-value: 5.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 106 RAFLAEVKQMRaRRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASdreavyACFTFSHWLVYANSAANPIIYNF 185
Cdd:cd15325  180 RVYVVALKFSR-EKKAAKTLGIVVGCFVLCWLPFFLVMPIGSIFPAYKPSD------TVFKITFWLGYFNSCINPIIYPC 252

                 ....*....
gi 766944309 186 LSGKFREQF 194
Cdd:cd15325  253 SSQEFKKAF 261
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
116-194 6.57e-06

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 45.81  E-value: 6.57e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 766944309 116 RARRKTAKMLMVVLLVFALCYLPISVLNVLKRvfgmFRQASDREAVYACFTFshWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15331  189 KRERKAARTLAIITGAFVVCWLPFFLVALVMP----FCGAWQISRFLESFFL--WLGYFNSLLNPIIYTIFSPDFRGAF 261
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
26-191 7.27e-06

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 45.96  E-value: 7.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  26 VCDEHWADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQipGTTSALVRNWKRPSEQleaqhqglctepqpra 105
Cdd:cd15395  159 VCLDQFPSDTIRLSYTTCLLVLQYFGPLCFIFICYLKIYIRLKRRN--NMMDKMRDNKYRSSET---------------- 220
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 106 raflaevkqmrarRKTAKMLMVVLLVFALCYLPISVLNVlkrVFGMfrqasDREAVYAC-----FTFSHWLVYANSAANP 180
Cdd:cd15395  221 -------------KRINIMLISIVVAFAVCWLPLNIFNA---VFDW-----NHEAIATCnhnllFLICHLTAMISTCVNP 279
                        170
                 ....*....|.
gi 766944309 181 IIYNFLSGKFR 191
Cdd:cd15395  280 IFYGFLNKNFQ 290
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
108-194 7.90e-06

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 45.88  E-value: 7.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 108 FLAEVKQmrarRKTAKMLMVVLLVFALCYLPISVLNVLkRVFGMFRQASDREAvyacfTFSHWLVYANSAANPIIYNFLS 187
Cdd:cd15060  184 FIATSKE----RRAARTLGIIMGVFVVCWLPFFLMYVI-LPFCETCSPSAKVV-----NFITWLGYVNSALNPVIYTIFN 253

                 ....*..
gi 766944309 188 GKFREQF 194
Cdd:cd15060  254 LDFRRAF 260
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
113-194 8.36e-06

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 45.88  E-value: 8.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 113 KQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFRE 192
Cdd:cd14977  211 KHMKQRRQLAKTVLCLVLVFAFCWLPEHISNILRATLYNEVLIDTRSTLDILDLIGQFLSFFNSCVNPIALYLLSEPFRR 290

                 ..
gi 766944309 193 QF 194
Cdd:cd14977  291 AF 292
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
46-194 9.25e-06

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 45.76  E-value: 9.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  46 IVTYLAPLGLMAMAYFQIFRkLWGRQIPgTTSALVR---NWKRPSEQLEAQHQGLCTEPQPRARAflaevkQMRARRKTA 122
Cdd:cd15320  178 LISFYIPVAIMIVTYTRIYR-IAQKQIR-RISALERaavHAKNCQNSTGNRGSGDCQQPESSFKM------SFKRETKVL 249
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 766944309 123 KMLMVVLLVFALCYLPISVLNVLKRvfgmFRQASDREAV---YACFTFSHWLVYANSAANPIIYNFlSGKFREQF 194
Cdd:cd15320  250 KTLSVIMGVFVCCWLPFFILNCMVP----FCKPTSTEPFcisSTTFDVFVWFGWANSSLNPIIYAF-NADFRKAF 319
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
38-192 1.13e-05

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 45.43  E-value: 1.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  38 KIYHSCFFIVTYLAPLGLMAMAYFQIFRKlwgrqipgttsalVRNWKrpseqleaqhqglctepqprARAFlaevkqmra 117
Cdd:cd15213  159 RIYVVLLLVAVFFIPFLIMLYSYFCILNT-------------VRSFK--------------------TRAF--------- 196
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 766944309 118 rrktaKMLMVVLLVFALCYLPISVLNVLkrvfGMFRQASDreAVYACFTFSHWLVYANSAANPIIYNFLSGKFRE 192
Cdd:cd15213  197 -----TTILILFIGFSVCWLPYTVYSLL----SVFSRYSS--SFYVISTCLLWLSYLKSAFNPVIYCWRIKKFRE 260
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
111-194 1.30e-05

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 44.93  E-value: 1.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 111 EVKQMRARRKTAkMLMVVLLVFALCYLPISVLNVLkrvFGMFRQASdrEAVYACFTFSHWLVYANSAANPIIYNFLSGKF 190
Cdd:cd15323  184 RVAKAREKRFTF-VLAVVMGVFVVCWFPFFFSYSL---YGICREAC--EVPEPLFKFFFWIGYCNSSLNPVIYTIFNQDF 257

                 ....
gi 766944309 191 REQF 194
Cdd:cd15323  258 RRSF 261
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
119-194 1.40e-05

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 44.92  E-value: 1.40e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 766944309 119 RKTAKMLMVVLLVFALCYLPISVLNVlkrvFGMFRQASDREAVYACFTfshWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15314  214 RKATKTLAIVMGVFLLCWTPFFLCNI----IDPFINYSIPPVLIEVLN---WLGYSNSTLNPFIYAFFYSWFRKAF 282
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
2-194 1.55e-05

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 45.08  E-value: 1.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309   2 VPQAAVMECSSVLPE--LANRTRLFSVCDEHWADelypKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsal 79
Cdd:cd15195  131 IPQSFIFSVLRKMPEqpGFHQCVDFGSAPTKKQE----RLYYFFTMILSFVIPLIITVTCYLLILFEI------------ 194
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  80 VRNWKRPSEQLEAQHQGLCTEPQPRARAflaevkqmrarrKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDRE 159
Cdd:cd15195  195 SKMAKRARDTPISNRRRSRTNSLERARM------------RTLRMTALIVLTFIVCWGPYYVLGLWYWFDKESIKNLPPA 262
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 766944309 160 AVYACFTFShwlvYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15195  263 LSHIMFLLG----YLNPCLHPIIYGVFMKEIRNWI 293
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
104-193 1.73e-05

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 44.80  E-value: 1.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 104 RARAFLAEVKQMRARRKTaKMLMVVLLVFALCYLPISVLNVLKrvfgmFRQASDREAVYACFTFSHWLVYANSAANPIIY 183
Cdd:cd15339  199 KAGRYNTSIPRQRVMRLT-KMVLVLVGVFLVSAAPYHVIQLVN-----LSVSQPTLAFYVSYYLSICLSYASSSINPFLY 272
                         90
                 ....*....|
gi 766944309 184 NFLSGKFREQ 193
Cdd:cd15339  273 ILLSGNFRKR 282
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
119-194 1.87e-05

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 44.75  E-value: 1.87e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 766944309 119 RKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQAsdreAVYACFTfshWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15317  222 RKAAKTLAIVMGIFLFCWLPYFIDTIVDEYSNFITPA----IVFDAVI---WLGYFNSAFNPFIYAFFYPWFRKAF 290
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
113-193 2.03e-05

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 44.43  E-value: 2.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 113 KQMRARRKTA-KMLMVVLLVFALCYLPisvLNVLKRVFGMFRQASDREAVYACFTFSHWLV--------YANSAANPIIY 183
Cdd:cd14989  189 RRLRPRRQKAlRMILVVVLVFFICWLP---ENVFISIQLLQGTQEPSESYDESFRHNHPLTghivnlaaFSNSCLNPLIY 265
                         90
                 ....*....|
gi 766944309 184 NFLSGKFREQ 193
Cdd:cd14989  266 SFLGETFRDK 275
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
113-194 2.98e-05

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 44.17  E-value: 2.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 113 KQMRARRKTAKMLMVVLLVFALCYLPISVLNVlkrvfgMFRQASDREAVYACFTFSHW-------LVYANSAANPIIYNF 185
Cdd:cd15130  199 KLVQALRRGVLVLRAVVIAFVVCWLPYHVRRL------MFCYISDEQWTTFLFDFYHYfymltnaLFYVSSAINPILYNL 272

                 ....*....
gi 766944309 186 LSGKFREQF 194
Cdd:cd15130  273 VSANFRQVF 281
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
118-183 3.37e-05

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 43.91  E-value: 3.37e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 766944309 118 RRKTAKMLMVVLLVFALCYLPISV---LNVLKRVF---GMFRQASDreAVYACFTFSHWLVYANSAANPIIY 183
Cdd:cd15967  201 KQRCLKLVIILIVLFSVCYIPYHVfrnLNLLSRILqkqGSCTQWFR--GIYIAHQVSRGLVCLNSALNPLVY 270
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
109-194 3.61e-05

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 44.07  E-value: 3.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 109 LAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFgmfrqaSDREAVYACFTFSHWLVY---------ANSAAN 179
Cdd:cd15976  208 IALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTI------YDEKDPNRCELLSFFLVLdyiginmasLNSCIN 281
                         90
                 ....*....|....*
gi 766944309 180 PIIYNFLSGKFREQF 194
Cdd:cd15976  282 PIALYLVSKRFKNCF 296
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
39-194 3.81e-05

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 43.85  E-value: 3.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  39 IYHSCFFIVTYLAPLGLMAMAYFQIFRKlwgrqipgttsalVRNWKRPSEQLEAQHQGLCTEpqpraraflAEVKQMRAR 118
Cdd:cd15337  165 LFILGLFIFGFLCPLLIIIFCYVNIIRA-------------VRNHEKEMTQTAKSGMGKDTE---------KNDARKKAE 222
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 119 RKTAKMLMVVLLVFALCYLPISVLNvlkrVFGMFRQAsdreavyacftfsHWL---------VYANSAA--NPIIYNFLS 187
Cdd:cd15337  223 IRIAKVAIILISLFLLSWTPYAVVA----LLGQFGPA-------------YWItpyvselpvMFAKASAiyNPIIYALSH 285

                 ....*..
gi 766944309 188 GKFREQF 194
Cdd:cd15337  286 PKFRAAL 292
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
116-189 4.13e-05

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 43.59  E-value: 4.13e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 766944309 116 RARRKTAKMLMVVLLVFALCYLPISVLNVLKRVF-GMFRQASDREAVYACFTFSHWLVYANSAANPIIYnFLSGK 189
Cdd:cd15373  204 RSKKKSVKMIIIVLAVFILCFLPFHVTRTLYYSFrSMDLSCGTLNAINLAYKVTRPLASANSCLDPILY-FLAGQ 277
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
111-193 4.25e-05

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 43.60  E-value: 4.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 111 EVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVF--GMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSG 188
Cdd:cd15381  199 KFKEIQTERKATVLVLAVLLMFFICWLPFHIFTFLDTLHklGLISGCRWEDILDIGTQIATFLAYSNSCLNPLLYVIVGK 278

                 ....*
gi 766944309 189 KFREQ 193
Cdd:cd15381  279 HFRKK 283
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
118-194 4.36e-05

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 43.75  E-value: 4.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 118 RRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASD----REAVYACFTFSHWLVYANSAANPIIYnFLSG-KFRE 192
Cdd:cd15377  209 RRKSIYLVIIVLTVFAVSYLPFHVMKTLNLRARLDFQTPAmcafNDRVYATYQVTRGLASLNSCVDPILY-FLAGdTFRR 287

                 ..
gi 766944309 193 QF 194
Cdd:cd15377  288 RL 289
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
112-194 4.61e-05

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 43.32  E-value: 4.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 112 VKQMRARRKTAkMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDreavyACFTFSHWLVYANSAANPIIYNFLSGKFR 191
Cdd:cd15324  180 VAKMREKRFTF-VLAVVMGVFVLCWFPFFFTYSLHAVCRKRCGIPD-----ALFNLFFWIGYCNSSVNPIIYTIFNRDFR 253

                 ...
gi 766944309 192 EQF 194
Cdd:cd15324  254 KAF 256
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
114-194 5.07e-05

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 43.54  E-value: 5.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 114 QMRARRKTAKMLMVVLLVFALCYLP--ISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFR 191
Cdd:cd15161  195 EKPLKDKAIKMIILVLTIFLICFVPyhISRYIYILSHNGAGASCSSRRGLALANRITSCLTCLNGALDPVMYFFVAEKFR 274

                 ...
gi 766944309 192 EQF 194
Cdd:cd15161  275 ETL 277
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
114-194 5.26e-05

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 43.36  E-value: 5.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 114 QMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVfgmfrqASDREAVYACFTFSHWLVY---------ANSAANPIIYN 184
Cdd:cd15977  213 HMKQRREVAKTVFCLVVIFALCWLPLHLSRILKKT------IYDVKDPQRCELLSFLLVMdytginmasLNSCINPVALY 286
                         90
                 ....*....|
gi 766944309 185 FLSGKFREQF 194
Cdd:cd15977  287 FVSRKFKNCF 296
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
116-191 5.78e-05

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 43.45  E-value: 5.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 116 RARRKTAKMLMVVLLVFALCYLPISVLNVLKrvfgMFRQAS----DREAVYACFTFShwlvYANSAANPIIYNFLSGKFR 191
Cdd:cd15382  224 RARSRTLKMTIVIVLVFIICWTPYFIMSLWY----WFDRESaskvDPRIQKGLFLFA----VSNSCMNPIVYGYFSIDLR 295
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
113-191 6.34e-05

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 43.22  E-value: 6.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 113 KQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVF--GMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKF 190
Cdd:cd15189  201 CEDRNDSKATALVLAVTLLFLVCWGPYHFFTFLDFLFdvGVLDECFWEHFIDIGLQLAVFLAFSNSCLNPVLYVFVGRYF 280

                 .
gi 766944309 191 R 191
Cdd:cd15189  281 R 281
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
111-194 6.58e-05

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 43.19  E-value: 6.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 111 EVKQMRARRKTA-KMLMVVLLVFALCYLPISVLNVLKRVFGM--FRQASDREAVYACFTFSHWLVYANSAANPIIYNFLS 187
Cdd:cd15192  199 EIQRNKPRNDEIfKMIMAVVLFFFFCWIPHQIFTFLDVLIQLkvIQDCHIADIVDTAMPFTICIAYFNSCLNPILYGFVG 278

                 ....*..
gi 766944309 188 GKFREQF 194
Cdd:cd15192  279 KNFRKKF 285
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
106-194 6.82e-05

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 42.96  E-value: 6.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 106 RAFLAEVKQMRaRRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASdreavyACFTFSHWLVYANSAANPIIYNF 185
Cdd:cd15326  180 RVYIVALKFSR-EKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSHLKPPE------TLFKIIFWLGYFNSCLNPIIYPC 252

                 ....*....
gi 766944309 186 LSGKFREQF 194
Cdd:cd15326  253 SSKEFKRAF 261
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
106-194 6.92e-05

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 42.98  E-value: 6.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 106 RAFLAEVKQMRaRRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASdreavyACFTFSHWLVYANSAANPIIYNF 185
Cdd:cd15327  180 RVYVVALKFSR-EKKAAKTLAIVVGVFILCWFPFFFVLPLGSFFPALKPSE------MVFKVIFWLGYFNSCVNPIIYPC 252

                 ....*....
gi 766944309 186 LSGKFREQF 194
Cdd:cd15327  253 SSKEFKRAF 261
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
116-194 7.54e-05

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 43.06  E-value: 7.54e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 766944309 116 RARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTfshwLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15090  205 RNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIA----LGYTNSCLNPVLYAFLDENFKRCF 279
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
114-194 8.45e-05

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 42.48  E-value: 8.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 114 QMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASdreavyACFTFSHWLVYANSAANPIIYNFLSGKFREQ 193
Cdd:cd15062  187 KFSREKKAAKTLGIVVGAFVLCWFPFFVVLPLGSLFSTLKPPE------PVFKVVFWLGYFNSCLNPIIYPCSSREFKRA 260

                 .
gi 766944309 194 F 194
Cdd:cd15062  261 F 261
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
113-194 9.01e-05

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 42.67  E-value: 9.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 113 KQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVfgmfRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFRE 192
Cdd:cd14974  197 KRLAKSSKPLRVLLAVVVAFFLCWLPYHVFALLELV----AAAGLPEVVLLGLPLATGLAYFNSCLNPILYVFMGQDFRK 272

                 ..
gi 766944309 193 QF 194
Cdd:cd14974  273 RL 274
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
115-194 9.32e-05

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 42.65  E-value: 9.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 115 MRARRKTAKMLMVVLLVFALCYLP--ISVL-NVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFR 191
Cdd:cd15178  197 SFQKHRAMRVIFAVVLAFLLCWLPynVTVLiDTLMRTKLITETCELRNHVDVALYVTQILGFLHSCINPVLYAFIGQKFR 276

                 ...
gi 766944309 192 EQF 194
Cdd:cd15178  277 NNL 279
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
46-183 1.26e-04

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 42.16  E-value: 1.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  46 IVTYLAPLGLMAMAYFQIFRKLwGRQIPGTTSALVRNWKRPSEQleaQHQGLCTEPQPRARAFLAEvkqmrarRKTAKML 125
Cdd:cd15957  172 IVSFYVPLVIMVFVYSRVFQEA-KRQLQKIDKSEGRFHNQNIDQ---NGSGGGGGNRRRSKFCLKE-------HKALKTL 240
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 766944309 126 MVVLLVFALCYLPISVLNVLKRVfgmfrqaSDREAVYACFTFSHWLVYANSAANPIIY 183
Cdd:cd15957  241 GIIMGTFTLCWLPFFIVNIVHVI-------QDNLIRKEVYILLNWIGYVNSGFNPLIY 291
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
116-191 1.71e-04

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 41.66  E-value: 1.71e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 766944309 116 RARRKTAKMLMVVLLVFALCYLPISVLNVLKRVF--GMFRQASDRE-AVYACFTFSHWLVYANSAANPIIYNFLSGKFR 191
Cdd:cd15193  198 RRRRNSLRIVFAIVTAFVLSWLPFNTLKAVRLLLelGGGVLPCHTTvAIRQGLTITACLAFVNSCVNPLIYSLLDRHFR 276
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
119-198 1.78e-04

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 41.83  E-value: 1.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 119 RKTAKMLMVVLLVFALCYLP--ISVLNVLKRVFGMFRQASDreavyacftFSHWLVYANSAANPIIYNflsgKFREQFKA 196
Cdd:cd15335  190 RKAARILGLILGAFILSWLPffIKELIVGLSVMTVSPEVAD---------FLTWLGYVNSLVNPLLYT----SFNEDFKL 256

                 ..
gi 766944309 197 AF 198
Cdd:cd15335  257 AF 258
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
111-192 1.79e-04

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 41.74  E-value: 1.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 111 EVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKrVFGMFRQASDREAVYACFtfshwLVYANSAANPIIYNFLSGKF 190
Cdd:cd15078  202 VIKILKYEKKVAKMCLLMISTFLICWMPYAVVSLLV-TSGYSKLVTPTIAIIPSL-----FAKSSTAYNPVIYIFMIRKF 275

                 ..
gi 766944309 191 RE 192
Cdd:cd15078  276 RQ 277
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
113-194 1.94e-04

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 41.70  E-value: 1.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 113 KQMRARRKTAkMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFRE 192
Cdd:cd15199  198 KQPKLQRAMA-LVTSVVVVFGFCFLPCFLARVLMLIFQNKESCNALNIAVHTYDVTMCLTYLNSVLDPIVYCFSSPTFRS 276

                 ..
gi 766944309 193 QF 194
Cdd:cd15199  277 SY 278
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
119-194 1.97e-04

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 41.36  E-value: 1.97e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 766944309 119 RKTAKMLMVVLLVFALCYLPISVLNVLKrvfGMFRQASDREAVYACFTfshWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15308  189 RKAMRVLPVVVGAFLFCWTPFFVVHITR---ALCESCSIPPQLISIVT---WLGYVNSALNPVIYTVFNAEFRNVF 258
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
105-191 1.97e-04

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 41.66  E-value: 1.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 105 ARAFLAE-VKQMR---ARRKTAKMLMVVLLVFALCYLP---------ISVLNVLKRVFGMFRQA-SDREAVYACftfshw 170
Cdd:cd15147  194 ARTLLSQpVQGQRnagVKRRALWMVCTVLAVFVICFVPhhvvqgpwtLAVLQQWRYWDCQFRQAlNDAHQITLC------ 267
                         90       100
                 ....*....|....*....|.
gi 766944309 171 LVYANSAANPIIYNFLSGKFR 191
Cdd:cd15147  268 LMSTNCVLDPVIYCFLTKKFR 288
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
119-198 2.06e-04

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 41.47  E-value: 2.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 119 RKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREavyacfTFSHWLVYANSAANPIIYNFlsgkFREQFKAAF 198
Cdd:cd15334  189 RKAATTLGLILGAFVICWLPFFVKEVIVNTCDSCYISEEMS------NFLTWLGYINSLINPLIYTI----FNEDFKKAF 258
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
45-194 2.17e-04

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 41.37  E-value: 2.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  45 FIVTYLAPLGLMAMAYFQIFRklwgrqipgttsaLVRnwkrpsEQLEAQHQGLCTEPQpraraflaevKQMRARRKTAKM 124
Cdd:cd15071  176 FFVWVLPPLLLMLLIYLEVFY-------------LIR------KQLNKKVSSSSSDPQ----------KYYGKELKIAKS 226
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 125 LMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVyACFtfshwLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15071  227 LALILFLFALSWLPLHILNCITLFCPSCKKPMILTYI-AIF-----LTHGNSAMNPIVYAFRIKKFRTTF 290
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
119-194 2.18e-04

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 41.31  E-value: 2.18e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 766944309 119 RKTAKMLMVVLLVFALCYLPISVLNVLkrvfgmfRQASDREAV-YACFTFSHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15296  202 KKVAKSLAIIVCVFGLCWAPYTLLMII-------RAACHGHCVpDYWYETSFWLLWVNSAINPVLYPLCHMSFRRAF 271
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
24-191 2.60e-04

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 41.22  E-value: 2.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  24 FSVCDEHWADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLwgRQIPGTTSAlvrnwkrpseqleaqhqglctepqp 103
Cdd:cd15160  148 HTLCYEKYPMEGWQASYNYARFLVGFLIPLSLILFFYRRVLRAV--RQSPSLERE------------------------- 200
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 104 raraflaevkqmrARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQA--SDREAVYACFTFSHWLVYANSAANPI 181
Cdd:cd15160  201 -------------EKRKIIGLLLSIVVIFLLCFLPYHVVLLVRSVIELVQNGlcGFEKRVFTAYQISLCLTSLNCVADPI 267
                        170
                 ....*....|
gi 766944309 182 IYNFLSGKFR 191
Cdd:cd15160  268 LYIFVTEDVR 277
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
113-194 2.61e-04

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 41.27  E-value: 2.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 113 KQMRARRKTAKMLMVVLLVFALCYLPISVLNVLK--RVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKF 190
Cdd:cd15191  202 KNKQRRDKVLKMVAAVVLAFLICWFPFHVLTFLDalARMGVINNCWVITVIDKALPFAICLGFSNSCINPFLYCFVGNHF 281

                 ....
gi 766944309 191 REQF 194
Cdd:cd15191  282 REKL 285
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
114-194 3.13e-04

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 40.97  E-value: 3.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 114 QMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVfgMFRQASDREAVYACFT-----FSHWLVYANSAANPIIYNFLSG 188
Cdd:cd15128  217 HLKQRREVAKTVFCLVVIFALCWLPLHLSRILKLT--VYDQNDPNRCELLSFLlvldyFGINLATLNSCINPIALYFVSR 294

                 ....*.
gi 766944309 189 KFREQF 194
Cdd:cd15128  295 KFKNCF 300
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
113-193 3.16e-04

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 40.90  E-value: 3.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 113 KQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFR---QASDREAVYACFTFSHWLVYANSAANPIIYNFLSGK 189
Cdd:cd15190  220 KEDKKKRRLLKIIITLVVTFALCWLPFHLVKTLYALMYLGIlpfSCGFDLFLMNAHPYATCLAYVNSCLNPFLYAFFDPR 299

                 ....
gi 766944309 190 FREQ 193
Cdd:cd15190  300 FRQQ 303
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
118-194 3.85e-04

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 40.89  E-value: 3.85e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 766944309 118 RRKTAKMLMVVLLVFALCYLPISVLNVLKR-VFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15172  204 RHKAVRVVVAVVLVFLVCQVPYNIVLLIEAiNLGEQQSCSSEKAVAYAKTITECLAFFHCCLNPVLYAFIGVKFRNYF 281
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
31-183 4.88e-04

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 40.50  E-value: 4.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  31 WADELYpkiyhSCF-FIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwKRPSEQLEAQHQGLCTEPQPRARAFL 109
Cdd:cd15384  161 WQEQLY-----NMLsLVFMFPIPLVIMVTCYVLIFITL----------------SKSSRDFQGLEIYTRNRGPNRQRLFH 219
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 766944309 110 aevkqmRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYacFTFShwlvYANSAANPIIY 183
Cdd:cd15384  220 ------KAKVKSLRMSAVIVTAFILCWTPYYVIMIWFLFFNPYPLNDILFDVI--FFFG----MSNSCVNPLIY 281
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
114-194 4.95e-04

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 40.26  E-value: 4.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 114 QMRARRKTAKMLMVVLLVFALCYLPISVLNVLkrvfGMFRQASDREaVYAcftfshWLVY----ANSAANPIIYNFLSGK 189
Cdd:cd15137  211 KSKRDMAVAKRFFLIVLTDFLCWIPIIVIGIL----ALSGVPIPGE-VYA------WVAVfvlpINSALNPILYTLSTPK 279

                 ....*
gi 766944309 190 FREQF 194
Cdd:cd15137  280 FRKKL 284
7tmA_MrgprA cd15105
mas-related G protein-coupled receptor subtype A, member of the class A family of ...
125-195 5.87e-04

mas-related G protein-coupled receptor subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320233  Cd Length: 276  Bit Score: 40.11  E-value: 5.87e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 766944309 125 LMVVLLVFALCYLPISV----LNVLKRVFGMFRqasdreavYACFTFSHWLVYANSAANPIIYnFLSGKFREQFK 195
Cdd:cd15105  195 IMLTVLVFLLCGLPFGIywflLFWIKDDFHVLD--------YGLYLASVVLTAVNSCANPIIY-FFVGSFRHRLK 260
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
119-194 5.87e-04

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 39.96  E-value: 5.87e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 766944309 119 RKTAKMLMVVLLVFALCYLPISVLNVLkrvfgMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15330  190 RKTVKTLGIIMGTFILCWLPFFIVALV-----LPFCESTCHMPELLGAIINWLGYSNSLLNPIIYAYFNKDFQSAF 260
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
109-194 6.90e-04

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 40.23  E-value: 6.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 109 LAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVfgMFRQASDREAVYACFT-----FSHWLVYANSAANPIIY 183
Cdd:cd15975  212 IALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKT--VYNENDPRRCELLSFLlvmdyISINLATMNSCINPIAL 289
                         90
                 ....*....|.
gi 766944309 184 NFLSGKFREQF 194
Cdd:cd15975  290 YFVSKKFKNCF 300
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
119-200 7.28e-04

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 39.89  E-value: 7.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 119 RKTAKMLMVVLLVFALCYLPISVLNVLkrvFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAF 198
Cdd:cd15305  197 RRASKVLGIVFFLFLIMWCPFFITNIL---SVLCKEACDQKLMEELLNVFVWVGYVSSGINPLVYTLFNKTYRRAFSNYI 273

                 ..
gi 766944309 199 SC 200
Cdd:cd15305  274 RC 275
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
111-194 7.40e-04

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 39.93  E-value: 7.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 111 EVKQMRARRKTAkMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASdreavyaCFTFSHWLVYANSAANPIIYNFLSGKF 190
Cdd:cd15322  184 QIAKNREKRFTF-VLAVVIGVFVICWFPFFFTYTLTAVCDCSVPET-------LFKFFFWFGYCNSSLNPVIYTIFNHDF 255

                 ....
gi 766944309 191 REQF 194
Cdd:cd15322  256 RRAF 259
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
38-191 8.36e-04

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 39.57  E-value: 8.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  38 KIYHSCFFIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwkRPSEQLEAQHQGLCTepqpraraflaevKQMRA 117
Cdd:cd15074  164 MSYIISIFIFCYLLPVLIIVFSYVKIIRKV-----------------KSSRKRVAGFDSRSK-------------RQHKI 213
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 766944309 118 RRKTAKMLMVVLLVFALCYLPISVLNVLKrVFGMFRQASDREAVYACFtfshwlvYANSAA--NPIIYNFLSGKFR 191
Cdd:cd15074  214 ERKVTKVAVLICAGFLIAWTPYAVVSMWS-AFGSPDSVPILASILPAL-------FAKSSCmyNPIIYLLFSSKFR 281
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
116-194 8.56e-04

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 39.67  E-value: 8.56e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 766944309 116 RARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDReAVYACFtfshWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15066  192 KREHKAAKTLGIIMGAFILCWLPFFLWYVTTTLCGDACPYPPI-LVSILF----WIGYFNSTLNPLIYAYFNRDFREAF 265
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
24-190 8.66e-04

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 39.65  E-value: 8.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  24 FSVCDEHWADElypkIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIpgttsalvrnwkrpseqleAQHQGLctepqp 103
Cdd:cd15201  153 FNICTGTDSSS----NWHEAMFLLEFFLPLAIILYCSVRIIWQLRGRQL-------------------DRHAKI------ 203
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 104 raraflaevkqmrarRKTAKMLMVVLLVFALCYLPISVLNVL---KRVFGMFRQASDREAVYACFTfSHWLVYANSAANP 180
Cdd:cd15201  204 ---------------KRAVQFIMVVAIVFIICFLPSNVTRIAiwiLKHTSNEDCQYYRSVDLAFYI-TISFTYFNSMLDP 267
                        170
                 ....*....|
gi 766944309 181 IIYNFLSGKF 190
Cdd:cd15201  268 VVYYFSSPSF 277
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
114-194 8.90e-04

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 39.51  E-value: 8.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 114 QMRARRKTAKMLMVVLLVFALCYLPISV---LNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKF 190
Cdd:cd14984  195 RNHKKHRALRVIFAVVVVFFLCWLPYNIvllLDTLQLLGIISRSCELSKSLDYALQVTESLAFSHCCLNPVLYAFVGVKF 274

                 ....
gi 766944309 191 REQF 194
Cdd:cd14984  275 RKYL 278
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
114-194 9.84e-04

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 39.46  E-value: 9.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 114 QMRARRKTAKMLMVVLLVFALCYLPISVlnvlKRVfgMFRQASDREAVYACFTFSHW-------LVYANSAANPIIYNFL 186
Cdd:cd15356  204 RIQSLQHSVQVLRAIVIAYVICWLPYHA----RRL--MFCYVPDDAWTDSLYNFYHYfymltntLFYVSSAVNPLLYNVV 277

                 ....*...
gi 766944309 187 SGKFREQF 194
Cdd:cd15356  278 SSSFRKLF 285
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
115-192 1.11e-03

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 39.45  E-value: 1.11e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 766944309 115 MRARRKTAKMLMVVLLVFALCYLPISVLNVLKrVFGmfRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFRE 192
Cdd:cd15403  225 MSFKTRAFTTILILFVGFSLCWLPHTVFSLLS-VFS--RRFYYSSSFYPISTCVLWLSYLKSVFNPVIYCWRIKKFRE 299
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
112-194 1.16e-03

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 39.13  E-value: 1.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 112 VKQMRARRKTAkMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDreavyACFTFSHWLVYANSAANPIIYNFLSGKFR 191
Cdd:cd15321  192 IAKNREKRFTF-VLAVVIGVFVLCWFPFFFSYSLGAICPELCKVPH-----SLFQFFFWIGYCNSSLNPVIYTIFNQDFR 265

                 ...
gi 766944309 192 EQF 194
Cdd:cd15321  266 RAF 268
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
109-194 1.33e-03

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 39.29  E-value: 1.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 109 LAEVKQMRARRKTAKMLMVVLlVFALCYLPISV---LNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF 185
Cdd:cd15180  193 LRSSQGFQKQRAIRVIVAVVV-VFFLCWTPYNIallVDTLIDLSVLDRNCGTESRLDIALSVTSSLGYFHCCLNPLLYAF 271

                 ....*....
gi 766944309 186 LSGKFREQF 194
Cdd:cd15180  272 VGVKFRRKL 280
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
119-193 1.33e-03

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 38.98  E-value: 1.33e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 766944309 119 RKTAKMLMVVLLVFALCYLPISVLNVLKrvfgMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQ 193
Cdd:cd15115  194 SKTFRVIIAVVVAFFVCWAPYHIIGILS----LYGDPPLSKVLMSWDHLSIALAYANSCLNPVLYVFMGKDFKKK 264
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
115-194 1.38e-03

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 38.88  E-value: 1.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 115 MRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDRE-----AVYAC--FTFSHWLVyansaaNPIIYNFLS 187
Cdd:cd15182  191 TMRKHRTVKLIFVIVLVFFLSWAPYNIVIFLRSLKDLTIPICECSkqldyAFYICrnIAFSHCCL------NPVFYVFVG 264

                 ....*..
gi 766944309 188 GKFREQF 194
Cdd:cd15182  265 VKFRNHL 271
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
113-200 1.43e-03

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 39.16  E-value: 1.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 113 KQMRARRKTAKMLMVVLLVFALCYLPISVLnVLKRVFgmfrqaSDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFRE 192
Cdd:cd15299  191 KETIKEKKAAQTLSAILLAFIITWTPYNIM-VLVNTF------CDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRT 263

                 ....*...
gi 766944309 193 QFKAAFSC 200
Cdd:cd15299  264 TFKMLLLC 271
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
110-189 1.61e-03

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 38.99  E-value: 1.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 110 AEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDR--EAVYACFTFSHWLVYANSAANPIIYnFLS 187
Cdd:cd15968  199 AEPPAQARRRKSIRTIVTVTLLFALCFLPFHITRTIYLAVRVTPGVPCHvlEAVAACYKITRPLASANSVLNPLLY-FLT 277

                 ..
gi 766944309 188 GK 189
Cdd:cd15968  278 KK 279
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
110-194 1.71e-03

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 38.64  E-value: 1.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 110 AEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNV--LKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLS 187
Cdd:cd15921  197 ALGRTRPSRRKACALIIISLGIFLVCFLPYHIVRTihLITERQIKESCGYILRVRKAAVITLCLAASNSCFDPLLYFFVG 276

                 ....*..
gi 766944309 188 GKFREQF 194
Cdd:cd15921  277 ENFRSRL 283
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
114-194 2.10e-03

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 38.66  E-value: 2.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 114 QMRARRKTAKMLMVVLLVFALCYLPISVLnvlkRVFGMFRQASDReaVYACFTFSHWLVYANSAANPIIYNFLSGKFREQ 193
Cdd:cd15099  207 RMRMDIRLAKTLSLILLVLAICWLPVLAF----MLVDVRVTLTNK--QKRMFAFCSMLCLVNSCVNPIIYALRSRELRGA 280

                 .
gi 766944309 194 F 194
Cdd:cd15099  281 M 281
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
116-194 2.23e-03

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 38.57  E-value: 2.23e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 766944309 116 RARRKTAKMLMVVLLVFALCYLPISvlnvLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15087  208 KAKKKVTLMVLVVLAVCLFCWTPFH----LSTVVALTTDLPQTPLVIGISYFITSLSYANSCLNPFLYAFLDDSFRKSF 282
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
116-194 2.28e-03

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 38.25  E-value: 2.28e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 766944309 116 RARRKTAKMLMVVLLVFALCYLPISVLNVLkrvfGMFRQASDREAVYACFtfsHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15063  195 RMETKAAKTVAIIVGCFIFCWLPFFTVYLV----RAFCEDCIPPLLFSVF---FWLGYCNSALNPCIYALFSRDFRFAF 266
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
113-194 2.36e-03

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 38.56  E-value: 2.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 113 KQMRARRKTAKMLMVVLLVFALCYLPISVLNVLK--RVFGMFRQASDREAVYACFTFShwLVYANSAANPIIYNFLSGKF 190
Cdd:cd15117  207 EGWVHSSRPFRVLTAVVAAFFLCWFPFHLVSLLElvVILNQKEDLNPLLILLLPLSSS--LACVNSCLNPLLYVFVGRDF 284

                 ....
gi 766944309 191 REQF 194
Cdd:cd15117  285 RERL 288
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
120-193 2.46e-03

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 38.24  E-value: 2.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 120 KTAKMLMVVLLVFALCYLPISVLNVLKRVFGMfrqasdrEAVYACF---------TFSHWLVYANSAANPIIYNFLSGKF 190
Cdd:cd15380  210 KATRLILTLVLMFLVCWTPYHFFAFLDFLFQV-------EVIQGCFweefidlglQLANFFAFANSCLNPVIYVFAGKLF 282

                 ...
gi 766944309 191 REQ 193
Cdd:cd15380  283 RTK 285
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
119-194 2.73e-03

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 38.19  E-value: 2.73e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 766944309 119 RKTAKMLMVVLLVFALCYLPISVLNVlkrVFGMFRQASDREAVYacFTFSHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15302  196 RKALRTITFILGAFVICWTPYHILAT---IYGFCEAPPCVNETL--YTISYYLCYMNSPINPFCYALANQQFKKTF 266
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
117-188 2.77e-03

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 38.22  E-value: 2.77e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 766944309 117 ARRKTAKMLMVVLLVFALCYLPIsvlnVLKRVFGMFRQASDREAvyACFTFSHWLVYANSAANPIIYNFLSG 188
Cdd:cd15388  224 AMIKTVKMTLVIVLVYVLCWAPF----FLVQLWSVWDPKAPTEG--ATFTILMLLASLNSCTNPWIYMAFSS 289
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
119-194 2.82e-03

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 38.03  E-value: 2.82e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 766944309 119 RKTAKMLMVVLLVFALCYLPISVLNVLKrvfgMFRQASDREAVYacfTFSHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd17790  194 KKAARTLSAILLAFILTWTPYNIMVLVS----TFCKDCVPKTLW---ELGYWLCYVNSTVNPMCYALCNKSFRDTF 262
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
116-192 2.90e-03

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 38.30  E-value: 2.90e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 766944309 116 RARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQAsdreavyACFTFSHWLVYANSAANPIIYNFLSGKFRE 192
Cdd:cd15316  219 RRERKAAKTLGITVIAFLVSWLPYLIDVLIDAFMNFITPP-------YIYEICCWCAYYNSAMNPLIYALFYPWFRK 288
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
31-188 3.09e-03

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 37.87  E-value: 3.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  31 WADELYP---KIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWgrqipgttsalvRNWKRPSEQleAQHQGLCTEPQprARA 107
Cdd:cd15387  149 WADFIQPwgpKAYITWITLSVYIIPVLILSVCYGLISFKIW------------QNVKLKTRR--ETKTPLSSAAS--GGA 212
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 108 FLAEVKQMR----ARRKTAKMLMVVLLVFALCYLPISVLnvlkRVFGMFRQASDREAvyACFTFSHWLVYANSAANPIIY 183
Cdd:cd15387  213 ALARVSSVKliskAKIRTVKMTFVIVLAYIVCWTPFFFV----QMWSVWDPNAPKEA--SPFIIAMLLASLNSCCNPWIY 286

                 ....*
gi 766944309 184 NFLSG 188
Cdd:cd15387  287 MFFTG 291
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
114-191 4.02e-03

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 37.51  E-value: 4.02e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 766944309 114 QMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQasdreaVYACFTFSHWLVYANSAANPIIYNFLSGKFR 191
Cdd:cd15341  205 RMRLDVRLAKTLGLVLAVLLICWSPVLALMMHSLFTSLSDH------IKKAFAFCSTLCLVNSMVNPIIYALRSRELR 276
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
116-192 4.21e-03

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 37.53  E-value: 4.21e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 766944309 116 RARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQAsdreavyACFTFSHWLVYANSAANPIIYNFLSGKFRE 192
Cdd:cd15318  211 KRERKAAKTLGIAVGVYLLCWLPFTIDTMVDSLLNFITPP-------LLFDIIIWFAYFNSACNPLIYVFSYPWFRK 280
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
124-194 4.23e-03

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 37.45  E-value: 4.23e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 766944309 124 MLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVyacFTFSHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15209  212 TMFVVFVLFAVCWAPLNFIGLAVAINPKEMAPKIPEWL---FVASYFMAYFNSCLNAIIYGLLNQNFRKEY 279
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
116-188 4.75e-03

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 37.46  E-value: 4.75e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 766944309 116 RARRKTAKMLMVVLLVFALCYLPISVLNVLKRVF----GMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSG 188
Cdd:cd14975  195 RRRRRTGRLIASVVVAFAACWLPYHVGNLLEVVSeligGSKMAGTLGKVAEAGRPIAGALAFLSSSINPLLYAFAAR 271
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
118-193 4.92e-03

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 37.48  E-value: 4.92e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 766944309 118 RRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDR-EAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQ 193
Cdd:cd15374  208 KKRSLKTIIMVLTVFAICFVPFHITRTLYYVARLLKADCDTlNIINVTYKVTRPLASANSCLDPILYFLAGDKYRRR 284
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
113-194 5.23e-03

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 37.31  E-value: 5.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 113 KQMRARRKTAKMLMVVLLVFALCYLPISVLnVLKRVFgmfrqaSDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFRE 192
Cdd:cd15300  188 KETIKERKAAQTLSAILLAFIITWTPYNIM-VLVSTF------CSDCIPLTLWHLGYWLCYVNSTVNPMCYALCNKTFRK 260

                 ..
gi 766944309 193 QF 194
Cdd:cd15300  261 TF 262
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
113-194 5.30e-03

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 37.41  E-value: 5.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 113 KQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKrvfgMFRQASDREAVYacfTFSHWLVYANSAANPIIYNFLSGKFRE 192
Cdd:cd15050  189 KAVNRERKAAKQLGFIMAAFILCWIPYFILFMVI----AFCKNCCNENLH---MFTIWLGYINSTLNPFIYPLCNENFKK 261

                 ..
gi 766944309 193 QF 194
Cdd:cd15050  262 TF 263
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
31-194 5.31e-03

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 37.49  E-value: 5.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  31 WADELYP---KIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWgRQIPGTTSALVRNWKRPSEQLeaqhqGLCtepqprara 107
Cdd:cd15385  153 WANFIVPwgiKAYITWITISIFVVPVIILLTCYGFICYNIW-RNIKCKTRRGLSDNALKNILL-----AVC--------- 217
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 108 fLAEVKQM-RARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFrqaSDREAVYACFTFSHWLVYANSAANPIIYNFL 186
Cdd:cd15385  218 -VSSVKTIsRAKIRTVKMTFVIVLAYIVCWAPFFTIQMWSVWDQNF---PWDESENTAVTITALLASLNSCCNPWIYMFF 293

                 ....*...
gi 766944309 187 SGKFREQF 194
Cdd:cd15385  294 SGHLLQDF 301
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
125-194 5.89e-03

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 37.14  E-value: 5.89e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 125 LMVVLLVFALCYLPisvLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15400  213 MFVVFVIFAICWAP---LNLIGLAVAINPQEMAPKVPEWLFVVSYFMAYFNSCLNAIIYGLLNQNFRKEY 279
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
114-194 6.17e-03

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 37.05  E-value: 6.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 114 QMRARRKTAKMLMVVLLVFALCYLPISVLNVLKrvfgMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQ 193
Cdd:cd15116  208 RLAKSSKPFKIIAAVIVTFFLCWAPYHILNLLE----MEATRSPASVFKIGLPITSSLAFINSCLNPILYVFMGQDFKKF 283

                 .
gi 766944309 194 F 194
Cdd:cd15116  284 K 284
7tmA_CB1 cd15340
cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...
114-194 6.33e-03

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320462 [Multi-domain]  Cd Length: 292  Bit Score: 37.20  E-value: 6.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 114 QMRARRKTAKMLMVVLLVFALCYLPISVLnvlkRVFGMFRQASDreAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQ 193
Cdd:cd15340  218 QTRMDIRLAKTLVLILVVLIICWGPLLAI----MVYDVFGKMNK--LIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHA 291

                 .
gi 766944309 194 F 194
Cdd:cd15340  292 F 292
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
116-190 6.36e-03

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 37.09  E-value: 6.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 116 RARRKTAKMLMVVLLVFALCYLPI------SVLNVlkrvfgmfrQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGK 189
Cdd:cd15386  227 RAKIRTVKMTFVIVLAYIACWAPFfsvqmwSVWDE---------NAPDEDSSDFAFTITMLLASLSSCCNPWIYMFFSGH 297

                 .
gi 766944309 190 F 190
Cdd:cd15386  298 L 298
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
38-192 8.24e-03

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 36.62  E-value: 8.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309  38 KIYHSCFFIVTYLAPLGLMAMAYFQIFRKlwgrqipgttsalVRNWKRPSEQLEAQHQGLCTEPQpraraflaevKQMRA 117
Cdd:cd15336  163 RAYTMLLFCFVFFIPLGIIIYCYLFIFLA-------------IRSTGREVQKLGSQDRKEKAKQY----------QRMKN 219
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766944309 118 RRKTAKMLMVVLLVFALCYLPISVLNVL-------------KRVFGMFRQASdreAVYacftfshwlvyansaaNPIIYN 184
Cdd:cd15336  220 EWKMAKIAFVVILLFVLSWSPYACVALIawagyahlltpymKSVPAVIAKAS---AIY----------------NPIIYA 280

                 ....*...
gi 766944309 185 FLSGKFRE 192
Cdd:cd15336  281 ITHPKYRE 288
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
119-194 8.77e-03

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 36.71  E-value: 8.77e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 766944309 119 RKTAKMLMVVLLVFALCYLPISVLNVLKRVFgmfrQASDREAVYAcFTFSHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15338  212 KKVTRMAVAICLAFFICWAPFYILQLAHLSI----DRPSLAFLYA-YNVAISMGYANSCINPFLYIMLSETFKRQF 282
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
119-194 9.95e-03

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 36.48  E-value: 9.95e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 766944309 119 RKTAKMLMVVLLVFALCYLPISVLNVLKrvfgMFRQASDREAVYacfTFSHWLVYANSAANPIIYNFLSGKFREQF 194
Cdd:cd15297  194 KKVTRTILAILLAFIITWTPYNVMVLIN----TFCASCIPNTVW---TIGYWLCYINSTINPACYALCNATFKKTF 262
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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