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Conserved domains on  [gi|748983076|ref|NP_001291288|]
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mucin-5AC precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 4911-5079 2.17e-44

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


:

Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 160.26  E-value: 2.17e-44
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076   4911 CCHHYQCQCVCSGWGDPHYITFDGTYYTFLDNCTYVLVQQIvPVYGHFRVLVDNYFCGaeDGLSCPRSIILEYHQDRVVL 4990
Cdd:smart00216    2 CCTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDC-SSEPTFSVLLKNVPCG--GGATCLKSVKVELNGDEIEL 78

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076   4991 TrKPVHGVMTNeiifNNKVVSPGFRKNGIVVSRIGVKMYATIPELGV-QVMFSGLI-FSVEVPfSKFANNTEGQCGTCTN 5068
Cdd:smart00216   79 K-DDNGKVTVN----GQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLiQVTFDGLTlLSVQLP-SKYRGKTCGLCGNFDG 152

                           170
                    ....*....|.
gi 748983076   5069 DRKDECRTPRG 5079
Cdd:smart00216  153 EPEDDFRTPDG 163
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 892-1051 5.36e-40

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


:

Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 147.55  E-value: 5.36e-40
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076    892 WRCTDDPCLATCAVYGDGHYLTFDGQSYSFNGDCEYTLVQnHCggkdSTQDSFRVVTENVPCGTTGtTCSKAIKIFLGGF 971
Cdd:smart00216    1 WCCTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQ-DC----SSEPTFSVLLKNVPCGGGA-TCLKSVKVELNGD 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076    972 ELKLSHGKVEVIGTDESQEVPYT-------IRQMGIYLVVDTDIGLV-LLWDKKTSIFINLSPEFKGRVCGLCGNFDDIA 1043
Cdd:smart00216   75 EIELKDDNGKVTVNGQQVSLPYKtsdgsiqIRSSGGYLVVITSLGLIqVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEP 154


                    ....*...
gi 748983076   1044 VNDFATRS 1051
Cdd:smart00216  155 EDDFRTPD 162
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 423-587 5.59e-37

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


:

Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 139.07  E-value: 5.59e-37
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076    423 WSCQEVPCPGTCSVLGGAHFSTFDGKQYTVHGDCSYVLTKPCDSS-AFTVLAELRRCGltDSETCLKSVTLSLDGaQTVV 501
Cdd:smart00216    1 WCCTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSEpTFSVLLKNVPCG--GGATCLKSVKVELNG-DEIE 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076    502 VIKASGEVFLNQIYTQLPISAANVTI-FRPSTFFIIAQTSLGLqLNLQLVPTMQLFMQLAPKLRGQTCGLCGNFNSIQAD 580
Cdd:smart00216   78 LKDDNGKVTVNGQQVSLPYKTSDGSIqIRSSGGYLVVITSLGL-IQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPED 156


                    ....*..
gi 748983076    581 DFRTLSG 587
Cdd:smart00216  157 DFRTPDG 163
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 1389-1475 3.07e-31

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


:

Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 119.36  E-value: 3.07e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  1389 WSPWMDVSRPGrGTDSGDFDTLENLRAHGyRVCESPRSVECRAEDAPGVPLRALGQRVQCSPDVGLTCRNREQASGLCYN 1468
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENPTDIECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPDGCLD 78


                   ....*..
gi 748983076  1469 YQIRVQC 1475
Cdd:pfam13330   79 YEVRFLC 85
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 1584-1670 2.53e-29

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


:

Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 113.97  E-value: 2.53e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  1584 WTEWIDGSYPApGINGGDFDTFQNLRDEGyTFCESPRSVQCRAESFPNTPLADLGQDVICSHTEGLICLNKNQLPPICYN 1663
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENPTDIECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPDGCLD 78


                   ....*..
gi 748983076  1664 YEIRIQC 1670
Cdd:pfam13330   79 YEVRFLC 85
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 1957-2043 2.53e-29

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


:

Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 113.97  E-value: 2.53e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  1957 WTEWIDGSYPApGINGGDFDTFQNLRDEGyTFCESPRSVQCRAESFPNTPLADLGQDVICSHTEGLICLNKNQLPPICYN 2036
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENPTDIECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPDGCLD 78


                   ....*..
gi 748983076  2037 YEIRIQC 2043
Cdd:pfam13330   79 YEVRFLC 85
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 3959-4050 2.71e-29

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


:

Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 113.97  E-value: 2.71e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  3959 WTKWFDVDFPSpGPHGGDKETYNNIIRSGeKICRRPEEItrlQCRAESHPEVSIEHLGQVVQCSREEGLVCRNQDQQGPf 4038
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENPTDI---ECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPD- 74

                           90
                   ....*....|..
gi 748983076  4039 kMCLNYEVRVLC 4050
Cdd:pfam13330   75 -GCLDYEVRFLC 85
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 4633-4724 3.69e-29

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


:

Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 113.58  E-value: 3.69e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  4633 WTKWFDVDFPSpGPHGGDKETYNNIIRSGeKICRRPEEItrlQCRAESHPEVNIEHLGQVVQCSREEGLVCRNQDQQGPf 4712
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENPTDI---ECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPD- 74

                           90
                   ....*....|..
gi 748983076  4713 kMCLNYEVRVLC 4724
Cdd:pfam13330   75 -GCLDYEVRFLC 85
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 1749-1840 6.18e-29

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


:

Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 112.81  E-value: 6.18e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  1749 WTKWFDVDFPSpGPHGGDKETYNNIIRSGeKICRRPEEItrlQCRAKSHPEVSIEHLGQVVQCSREEGLVCRNQDQQGPf 1828
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENPTDI---ECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPD- 74

                           90
                   ....*....|..
gi 748983076  1829 kMCLNYEVRVLC 1840
Cdd:pfam13330   75 -GCLDYEVRFLC 85
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 3526-3617 6.18e-29

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


:

Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 112.81  E-value: 6.18e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  3526 WTKWFDVDFPSpGPHGGDKETYNNIIRSGeKICRRPEEItrlQCRAKSHPEVSIEHLGQVVQCSREEGLVCRNQDQQGPf 3605
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENPTDI---ECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPD- 74

                           90
                   ....*....|..
gi 748983076  3606 kMCLNYEVRVLC 3617
Cdd:pfam13330   75 -GCLDYEVRFLC 85
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 2122-2213 6.43e-29

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


:

Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 112.81  E-value: 6.43e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  2122 WTTWFDVDFPSpGPHGGDKETYNNIIRSGeKICRRPEEItrlQCRAKSHPEVSIEHLGQVVQCSREEGLVCRNQDQQGPf 2201
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENPTDI---ECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPD- 74

                           90
                   ....*....|..
gi 748983076  2202 kMCLNYEVRVLC 2213
Cdd:pfam13330   75 -GCLDYEVRFLC 85
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 3228-3319 7.15e-29

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


:

Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 112.81  E-value: 7.15e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  3228 WTKWFDIDFPSpGPHGGDKETYNNIIRSGeKICRRPEEItrlQCRAESHPEVSIEHLGQVVQCSREEGLVCRNQDQQGPf 3307
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENPTDI---ECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPD- 74

                           90
                   ....*....|..
gi 748983076  3308 kMCLNYEVRVLC 3319
Cdd:pfam13330   75 -GCLDYEVRFLC 85
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 74-216 1.02e-28

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


:

Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 115.19  E-value: 1.02e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076     74 PAHNGRVCSTWGSFHYKTFDGDVFRFPGLCNYVFSEHCGaAYEDFNIQLRRSQESAAPT-LSRVLMKVDGVVIQLTK--G 150
Cdd:smart00216    5 QEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCS-SEPTFSVLLKNVPCGGGATcLKSVKVELNGDEIELKDdnG 83

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 748983076    151 SVLVNGHPVLLPFSQSGVLIQQSSS--YTKVEARLGLV-LMWNHDDSLLLELDTKYANKTCGLCGDFNG 216
Cdd:smart00216   84 KVTVNGQQVSLPYKTSDGSIQIRSSggYLVVITSLGLIqVTFDGLTLLSVQLPSKYRGKTCGLCGNFDG 152
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 624-694 4.78e-25

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


:

Pssm-ID: 214843  Cd Length: 76  Bit Score: 101.65  E-value: 4.78e-25
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 748983076    624 EKYAQHWCSQLTDADGPFGRCHAAVKPGTYYSNCMFDTCNCERSEDCLCAALSSYVHACAAKGVQLGGWRD 694
Cdd:smart00832    1 KYYACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRT 71
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1088-1162 2.65e-24

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


:

Pssm-ID: 214843  Cd Length: 76  Bit Score: 99.34  E-value: 2.65e-24
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 748983076   1088 KSWAQKQCSILHGP--TFAACHAHVEPARYYEACVNDACACdsGGDCECFCTAVAAYAQACHEVGLCVS-WRTPSICP 1162
Cdd:smart00832    1 KYYACSQCGILLSPrgPFAACHSVVDPEPFFENCVYDTCAC--GGDCECLCDALAAYAAACAEAGVCISpWRTPTFCP 76
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 5534-5616 2.68e-18

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


:

Pssm-ID: 214482  Cd Length: 82  Bit Score: 82.45  E-value: 2.68e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076   5534 VYHRSLIIQQQGCSSSEpVRLAYCRGNCGDSSSmysLEGNTVEHRCQCCQELRTSLRNVTLHCTDGSSRAFSYTEVEECG 5613
Cdd:smart00041    1 KSPVRQTITYNGCTSVT-VKNAFCEGKCGSASS---YSIQDVQHSCSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECG 76


                    ...
gi 748983076   5614 CMG 5616
Cdd:smart00041   77 CEP 79
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 265-334 1.03e-14

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


:

Pssm-ID: 462584  Cd Length: 68  Bit Score: 71.64  E-value: 1.03e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076   265 ICEELLHGQLFSGCVALVDVGSYLEACRQDLCFCEDTDllSCVCHTLAEYSRQCTHAGGLPQDWRGPDFC 334
Cdd:pfam08742    1 KCGLLSDSGPFAPCHSVVDPEPYFEACVYDMCSCGGDD--ECLCAALAAYARACQAAGVCIGDWRTPTFC 68
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 338-394 2.41e-14

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


:

Pssm-ID: 410995  Cd Length: 55  Bit Score: 70.42  E-value: 2.41e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 748983076  338 CPNNMQYHECRSPCADTCSNQEHSRACEDHCVAGCFCPEGTVLDDIGQtgCVPVSKC 394
Cdd:cd19941     1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNSGGK--CVPPSQC 55
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 5146-5205 2.95e-10

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


:

Pssm-ID: 462584  Cd Length: 68  Bit Score: 59.32  E-value: 2.95e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 748983076  5146 ICQLILSK-VFEPCHTVIPPLLFYEGCVFDRCHMT-DLDVVCSSLELYAALCASHDICI-DWR 5205
Cdd:pfam08742    1 KCGLLSDSgPFAPCHSVVDPEPYFEACVYDMCSCGgDDECLCAALAAYARACQAAGVCIgDWR 63
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 802-863 5.42e-06

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


:

Pssm-ID: 410995  Cd Length: 55  Bit Score: 46.54  E-value: 5.42e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 748983076  802 CAAPMVFFDCrnatpgdtGAGCQKSCHTLD--MTCySPQCVPGCVCPDGLVADGEGGCITAEDC 863
Cdd:cd19941     1 CPPNEVYSEC--------GSACPPTCANPNapPPC-TKQCVEGCFCPEGYVRNSGGKCVPPSQC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 704-761 1.87e-05

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


:

Pssm-ID: 410995  Cd Length: 55  Bit Score: 45.00  E-value: 1.87e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 748983076  704 CPKSMTYHYHVSTCQPTCRSLsEGDITCSVGFIPvdGCICPKGTFLDDTGKCVQASNC 761
Cdd:cd19941     1 CPPNEVYSECGSACPPTCANP-NAPPPCTKQCVE--GCFCPEGYVRNSGGKCVPPSQC 55
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 1335-1576 5.85e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 5.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076 1335 PLVVSSTHTPSNGPSSAH-------------TGPPSSAWPTTAGTSPRTRLPTASASLPPVCGEKCLWSPWMD------- 1394
Cdd:PHA03247 2580 PAVTSRARRPDAPPQSARprapvddrgdprgPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPrddpapg 2659

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076 1395 -VSRPGR----GTDSGDFDTLENLRAHGYRVCESPRSVECRAEDAPGVPLRALGQRVQCSPDVGLTCRNREQASGlcyny 1469
Cdd:PHA03247 2660 rVSRPRRarrlGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPA----- 2734

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076 1470 qirvqccTPLPCSTSSSPAQTTPPTTSKTTETRASGSSAPSSTPGTVSLST-ARTTPAPGTATSVKKTFSTPSPPPvPAT 1548
Cdd:PHA03247 2735 -------LPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGpPRRLTRPAVASLSESRESLPSPWD-PAD 2806

                         250       260
                  ....*....|....*....|....*...
gi 748983076 1549 STSSMSTTAPGTSVVSSKPTPTEPSTSS 1576
Cdd:PHA03247 2807 PPAAVLAPAAALPPAASPAGPLPPPTSA 2834
 
Name Accession Description Interval E-value
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 4911-5079 2.17e-44

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 160.26  E-value: 2.17e-44
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076   4911 CCHHYQCQCVCSGWGDPHYITFDGTYYTFLDNCTYVLVQQIvPVYGHFRVLVDNYFCGaeDGLSCPRSIILEYHQDRVVL 4990
Cdd:smart00216    2 CCTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDC-SSEPTFSVLLKNVPCG--GGATCLKSVKVELNGDEIEL 78

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076   4991 TrKPVHGVMTNeiifNNKVVSPGFRKNGIVVSRIGVKMYATIPELGV-QVMFSGLI-FSVEVPfSKFANNTEGQCGTCTN 5068
Cdd:smart00216   79 K-DDNGKVTVN----GQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLiQVTFDGLTlLSVQLP-SKYRGKTCGLCGNFDG 152

                           170
                    ....*....|.
gi 748983076   5069 DRKDECRTPRG 5079
Cdd:smart00216  153 EPEDDFRTPDG 163
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 892-1051 5.36e-40

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 147.55  E-value: 5.36e-40
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076    892 WRCTDDPCLATCAVYGDGHYLTFDGQSYSFNGDCEYTLVQnHCggkdSTQDSFRVVTENVPCGTTGtTCSKAIKIFLGGF 971
Cdd:smart00216    1 WCCTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQ-DC----SSEPTFSVLLKNVPCGGGA-TCLKSVKVELNGD 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076    972 ELKLSHGKVEVIGTDESQEVPYT-------IRQMGIYLVVDTDIGLV-LLWDKKTSIFINLSPEFKGRVCGLCGNFDDIA 1043
Cdd:smart00216   75 EIELKDDNGKVTVNGQQVSLPYKtsdgsiqIRSSGGYLVVITSLGLIqVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEP 154


                    ....*...
gi 748983076   1044 VNDFATRS 1051
Cdd:smart00216  155 EDDFRTPD 162
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 423-587 5.59e-37

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 139.07  E-value: 5.59e-37
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076    423 WSCQEVPCPGTCSVLGGAHFSTFDGKQYTVHGDCSYVLTKPCDSS-AFTVLAELRRCGltDSETCLKSVTLSLDGaQTVV 501
Cdd:smart00216    1 WCCTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSEpTFSVLLKNVPCG--GGATCLKSVKVELNG-DEIE 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076    502 VIKASGEVFLNQIYTQLPISAANVTI-FRPSTFFIIAQTSLGLqLNLQLVPTMQLFMQLAPKLRGQTCGLCGNFNSIQAD 580
Cdd:smart00216   78 LKDDNGKVTVNGQQVSLPYKTSDGSIqIRSSGGYLVVITSLGL-IQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPED 156


                    ....*..
gi 748983076    581 DFRTLSG 587
Cdd:smart00216  157 DFRTPDG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 434-588 1.83e-34

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 131.34  E-value: 1.83e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076   434 CSVLGGAHFSTFDGKQYTVHGDCSYVLTKPCDS-SAFTVLAELRRCGLTDSETCLKSVTLSLDGaqTVVVIKASGEVFLN 512
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEePDFSFSVTNKNCNGGASGVCLKSVTVIVGD--LEITLQKGGTVLVN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 748983076   513 QIYTQLPISAANVTIFRPSTFFIIAQTSLGLQLNLQLVPTMQLFMQLAPKLRGQTCGLCGNFNSIQADDFRTLSGV 588
Cdd:pfam00094   79 GQKVSLPYKSDGGEVEILGSGFVVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 903-1051 2.50e-32

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 125.18  E-value: 2.50e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076   903 CAVYGDGHYLTFDGQSYSFNGDCEYTLVQNhCGGkdSTQDSFRVVTENVPCGTTGTtCSKAIKIFLGGFELKLSHGKVEV 982
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKD-CSE--EPDFSFSVTNKNCNGGASGV-CLKSVTVIVGDLEITLQKGGTVL 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 748983076   983 IGTDESqEVPYT-----IRQMG---IYLVVDTDIGLVLLWDKKTSIFINLSPEFKGRVCGLCGNFDDIAVNDFATRS 1051
Cdd:pfam00094   77 VNGQKV-SLPYKsdggeVEILGsgfVVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPD 152
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 1389-1475 3.07e-31

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 119.36  E-value: 3.07e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  1389 WSPWMDVSRPGrGTDSGDFDTLENLRAHGyRVCESPRSVECRAEDAPGVPLRALGQRVQCSPDVGLTCRNREQASGLCYN 1468
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENPTDIECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPDGCLD 78


                   ....*..
gi 748983076  1469 YQIRVQC 1475
Cdd:pfam13330   79 YEVRFLC 85
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 4921-5080 4.45e-30

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 118.63  E-value: 4.45e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  4921 CSGWGDPHYITFDGTYYTFLDNCTYVLVqQIVPVYGHFRVLVDNYFCGAEDGLSCPRSIILEYHQDRVVLTRkpvhgvmT 5000
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLA-KDCSEEPDFSFSVTNKNCNGGASGVCLKSVTVIVGDLEITLQK-------G 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  5001 NEIIFNNKVVSPGFRKNGIVVSRIGVKMYATIPELGVQVMFSGL-IFSVEVPFSKFANN-TEGQCGTCTNDRKDECRTPR 5078
Cdd:pfam00094   73 GTVLVNGQKVSLPYKSDGGEVEILGSGFVVVDLSPGVGLQVDGDgRGQLFVTLSPSYQGkTCGLCGNYNGNQEDDFMTPD 152


                   ..
gi 748983076  5079 GT 5080
Cdd:pfam00094  153 GT 154
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 1584-1670 2.53e-29

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 113.97  E-value: 2.53e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  1584 WTEWIDGSYPApGINGGDFDTFQNLRDEGyTFCESPRSVQCRAESFPNTPLADLGQDVICSHTEGLICLNKNQLPPICYN 1663
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENPTDIECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPDGCLD 78


                   ....*..
gi 748983076  1664 YEIRIQC 1670
Cdd:pfam13330   79 YEVRFLC 85
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 1957-2043 2.53e-29

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 113.97  E-value: 2.53e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  1957 WTEWIDGSYPApGINGGDFDTFQNLRDEGyTFCESPRSVQCRAESFPNTPLADLGQDVICSHTEGLICLNKNQLPPICYN 2036
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENPTDIECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPDGCLD 78


                   ....*..
gi 748983076  2037 YEIRIQC 2043
Cdd:pfam13330   79 YEVRFLC 85
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 3959-4050 2.71e-29

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 113.97  E-value: 2.71e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  3959 WTKWFDVDFPSpGPHGGDKETYNNIIRSGeKICRRPEEItrlQCRAESHPEVSIEHLGQVVQCSREEGLVCRNQDQQGPf 4038
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENPTDI---ECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPD- 74

                           90
                   ....*....|..
gi 748983076  4039 kMCLNYEVRVLC 4050
Cdd:pfam13330   75 -GCLDYEVRFLC 85
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 4633-4724 3.69e-29

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 113.58  E-value: 3.69e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  4633 WTKWFDVDFPSpGPHGGDKETYNNIIRSGeKICRRPEEItrlQCRAESHPEVNIEHLGQVVQCSREEGLVCRNQDQQGPf 4712
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENPTDI---ECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPD- 74

                           90
                   ....*....|..
gi 748983076  4713 kMCLNYEVRVLC 4724
Cdd:pfam13330   75 -GCLDYEVRFLC 85
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 1749-1840 6.18e-29

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 112.81  E-value: 6.18e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  1749 WTKWFDVDFPSpGPHGGDKETYNNIIRSGeKICRRPEEItrlQCRAKSHPEVSIEHLGQVVQCSREEGLVCRNQDQQGPf 1828
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENPTDI---ECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPD- 74

                           90
                   ....*....|..
gi 748983076  1829 kMCLNYEVRVLC 1840
Cdd:pfam13330   75 -GCLDYEVRFLC 85
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 3526-3617 6.18e-29

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 112.81  E-value: 6.18e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  3526 WTKWFDVDFPSpGPHGGDKETYNNIIRSGeKICRRPEEItrlQCRAKSHPEVSIEHLGQVVQCSREEGLVCRNQDQQGPf 3605
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENPTDI---ECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPD- 74

                           90
                   ....*....|..
gi 748983076  3606 kMCLNYEVRVLC 3617
Cdd:pfam13330   75 -GCLDYEVRFLC 85
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 2122-2213 6.43e-29

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 112.81  E-value: 6.43e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  2122 WTTWFDVDFPSpGPHGGDKETYNNIIRSGeKICRRPEEItrlQCRAKSHPEVSIEHLGQVVQCSREEGLVCRNQDQQGPf 2201
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENPTDI---ECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPD- 74

                           90
                   ....*....|..
gi 748983076  2202 kMCLNYEVRVLC 2213
Cdd:pfam13330   75 -GCLDYEVRFLC 85
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 3228-3319 7.15e-29

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 112.81  E-value: 7.15e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  3228 WTKWFDIDFPSpGPHGGDKETYNNIIRSGeKICRRPEEItrlQCRAESHPEVSIEHLGQVVQCSREEGLVCRNQDQQGPf 3307
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENPTDI---ECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPD- 74

                           90
                   ....*....|..
gi 748983076  3308 kMCLNYEVRVLC 3319
Cdd:pfam13330   75 -GCLDYEVRFLC 85
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 74-216 1.02e-28

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 115.19  E-value: 1.02e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076     74 PAHNGRVCSTWGSFHYKTFDGDVFRFPGLCNYVFSEHCGaAYEDFNIQLRRSQESAAPT-LSRVLMKVDGVVIQLTK--G 150
Cdd:smart00216    5 QEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCS-SEPTFSVLLKNVPCGGGATcLKSVKVELNGDEIELKDdnG 83

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 748983076    151 SVLVNGHPVLLPFSQSGVLIQQSSS--YTKVEARLGLV-LMWNHDDSLLLELDTKYANKTCGLCGDFNG 216
Cdd:smart00216   84 KVTVNGQQVSLPYKTSDGSIQIRSSggYLVVITSLGLIqVTFDGLTLLSVQLPSKYRGKTCGLCGNFDG 152
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 81-218 5.96e-27

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 109.77  E-value: 5.96e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076    81 CSTWGSFHYKTFDGDVFRFPGLCNYVFSEHCGAAYED-FNIQLRRSQESA-APTLSRVLMKVDGVVIQLTKG-SVLVNGH 157
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPDFsFSVTNKNCNGGAsGVCLKSVTVIVGDLEITLQKGgTVLVNGQ 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 748983076   158 PVLLPFSQSGVLIQQSSSY---TKVEARLGLVLMWNHDDSLLLELDTKYANKTCGLCGDFNGMP 218
Cdd:pfam00094   81 KVSLPYKSDGGEVEILGSGfvvVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQ 144
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 624-694 4.78e-25

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 101.65  E-value: 4.78e-25
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 748983076    624 EKYAQHWCSQLTDADGPFGRCHAAVKPGTYYSNCMFDTCNCERSEDCLCAALSSYVHACAAKGVQLGGWRD 694
Cdd:smart00832    1 KYYACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRT 71
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1088-1162 2.65e-24

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 99.34  E-value: 2.65e-24
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 748983076   1088 KSWAQKQCSILHGP--TFAACHAHVEPARYYEACVNDACACdsGGDCECFCTAVAAYAQACHEVGLCVS-WRTPSICP 1162
Cdd:smart00832    1 KYYACSQCGILLSPrgPFAACHSVVDPEPFFENCVYDTCAC--GGDCECLCDALAAYAAACAEAGVCISpWRTPTFCP 76
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 630-693 6.24e-20

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 86.67  E-value: 6.24e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 748983076   630 WCSQLTDaDGPFGRCHAAVKPGTYYSNCMFDTCNCERSEDCLCAALSSYVHACAAKGVQLGGWR 693
Cdd:pfam08742    1 KCGLLSD-SGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWR 63
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1094-1161 4.25e-19

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 84.35  E-value: 4.25e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  1094 QCSIL-HGPTFAACHAHVEPARYYEACVNDACACdsGGDCECFCTAVAAYAQACHEVGLCV-SWRTPSIC 1161
Cdd:pfam08742    1 KCGLLsDSGPFAPCHSVVDPEPYFEACVYDMCSC--GGDDECLCAALAAYARACQAAGVCIgDWRTPTFC 68
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 5534-5616 2.68e-18

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 82.45  E-value: 2.68e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076   5534 VYHRSLIIQQQGCSSSEpVRLAYCRGNCGDSSSmysLEGNTVEHRCQCCQELRTSLRNVTLHCTDGSSRAFSYTEVEECG 5613
Cdd:smart00041    1 KSPVRQTITYNGCTSVT-VKNAFCEGKCGSASS---YSIQDVQHSCSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECG 76


                    ...
gi 748983076   5614 CMG 5616
Cdd:smart00041   77 CEP 79
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 265-334 1.03e-14

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 71.64  E-value: 1.03e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076   265 ICEELLHGQLFSGCVALVDVGSYLEACRQDLCFCEDTDllSCVCHTLAEYSRQCTHAGGLPQDWRGPDFC 334
Cdd:pfam08742    1 KCGLLSDSGPFAPCHSVVDPEPYFEACVYDMCSCGGDD--ECLCAALAAYARACQAAGVCIGDWRTPTFC 68
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 338-394 2.41e-14

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 70.42  E-value: 2.41e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 748983076  338 CPNNMQYHECRSPCADTCSNQEHSRACEDHCVAGCFCPEGTVLDDIGQtgCVPVSKC 394
Cdd:cd19941     1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNSGGK--CVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 338-394 1.52e-12

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 65.10  E-value: 1.52e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 748983076   338 CPNNMQYHECRSPCADTCSNQEHSRACEDHCVAGCFCPEGTVLDDIGQtgCVPVSKC 394
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVCPEPCVEGCVCPPGFVRNSGGK--CVPPSDC 55
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 5146-5205 2.95e-10

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 59.32  E-value: 2.95e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 748983076  5146 ICQLILSK-VFEPCHTVIPPLLFYEGCVFDRCHMT-DLDVVCSSLELYAALCASHDICI-DWR 5205
Cdd:pfam08742    1 KCGLLSDSgPFAPCHSVVDPEPYFEACVYDMCSCGgDDECLCAALAAYARACQAAGVCIgDWR 63
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 275-335 7.44e-10

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 58.12  E-value: 7.44e-10
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 748983076    275 FSGCVALVDVGSYLEACRQDLCFCEDTDLlsCVCHTLAEYSRQCTHAGGLPQDWRGPDFCP 335
Cdd:smart00832   18 FAACHSVVDPEPFFENCVYDTCACGGDCE--CLCDALAAYAAACAEAGVCISPWRTPTFCP 76
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 5147-5213 1.31e-09

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 57.74  E-value: 1.31e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 748983076   5147 CQLILSK--VFEPCHTVIPPLLFYEGCVFDRC-HMTDLDVVCSSLELYAALCASHDICI-DWRGRTghMCP 5213
Cdd:smart00832    8 CGILLSPrgPFAACHSVVDPEPFFENCVYDTCaCGGDCECLCDALAAYAAACAEAGVCIsPWRTPT--FCP 76
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 802-863 5.42e-06

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 46.54  E-value: 5.42e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 748983076  802 CAAPMVFFDCrnatpgdtGAGCQKSCHTLD--MTCySPQCVPGCVCPDGLVADGEGGCITAEDC 863
Cdd:cd19941     1 CPPNEVYSEC--------GSACPPTCANPNapPPC-TKQCVEGCFCPEGYVRNSGGKCVPPSQC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 704-761 1.87e-05

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 45.00  E-value: 1.87e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 748983076  704 CPKSMTYHYHVSTCQPTCRSLsEGDITCSVGFIPvdGCICPKGTFLDDTGKCVQASNC 761
Cdd:cd19941     1 CPPNEVYSECGSACPPTCANP-NAPPPCTKQCVE--GCFCPEGYVRNSGGKCVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 802-863 3.10e-04

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 41.60  E-value: 3.10e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 748983076   802 CAAPMVFFDCrnatpgdtGAGCQKSCHTL--DMTCySPQCVPGCVCPDGLVADGEGGCITAEDC 863
Cdd:pfam01826    1 CPANEVYSEC--------GSACPPTCANLspPDVC-PEPCVEGCVCPPGFVRNSGGKCVPPSDC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 704-761 6.23e-04

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 40.83  E-value: 6.23e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 748983076   704 CPKSMTYHYHVSTCQPTCRSLSEGDI---TCsvgfipVDGCICPKGTFLDDTGKCVQASNC 761
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVcpePC------VEGCVCPPGFVRNSGGKCVPPSDC 55
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1335-1576 5.85e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 5.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076 1335 PLVVSSTHTPSNGPSSAH-------------TGPPSSAWPTTAGTSPRTRLPTASASLPPVCGEKCLWSPWMD------- 1394
Cdd:PHA03247 2580 PAVTSRARRPDAPPQSARprapvddrgdprgPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPrddpapg 2659

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076 1395 -VSRPGR----GTDSGDFDTLENLRAHGYRVCESPRSVECRAEDAPGVPLRALGQRVQCSPDVGLTCRNREQASGlcyny 1469
Cdd:PHA03247 2660 rVSRPRRarrlGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPA----- 2734

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076 1470 qirvqccTPLPCSTSSSPAQTTPPTTSKTTETRASGSSAPSSTPGTVSLST-ARTTPAPGTATSVKKTFSTPSPPPvPAT 1548
Cdd:PHA03247 2735 -------LPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGpPRRLTRPAVASLSESRESLPSPWD-PAD 2806

                         250       260
                  ....*....|....*....|....*...
gi 748983076 1549 STSSMSTTAPGTSVVSSKPTPTEPSTSS 1576
Cdd:PHA03247 2807 PPAAVLAPAAALPPAASPAGPLPPPTSA 2834
 
Name Accession Description Interval E-value
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 4911-5079 2.17e-44

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 160.26  E-value: 2.17e-44
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076   4911 CCHHYQCQCVCSGWGDPHYITFDGTYYTFLDNCTYVLVQQIvPVYGHFRVLVDNYFCGaeDGLSCPRSIILEYHQDRVVL 4990
Cdd:smart00216    2 CCTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDC-SSEPTFSVLLKNVPCG--GGATCLKSVKVELNGDEIEL 78

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076   4991 TrKPVHGVMTNeiifNNKVVSPGFRKNGIVVSRIGVKMYATIPELGV-QVMFSGLI-FSVEVPfSKFANNTEGQCGTCTN 5068
Cdd:smart00216   79 K-DDNGKVTVN----GQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLiQVTFDGLTlLSVQLP-SKYRGKTCGLCGNFDG 152

                           170
                    ....*....|.
gi 748983076   5069 DRKDECRTPRG 5079
Cdd:smart00216  153 EPEDDFRTPDG 163
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 892-1051 5.36e-40

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 147.55  E-value: 5.36e-40
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076    892 WRCTDDPCLATCAVYGDGHYLTFDGQSYSFNGDCEYTLVQnHCggkdSTQDSFRVVTENVPCGTTGtTCSKAIKIFLGGF 971
Cdd:smart00216    1 WCCTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQ-DC----SSEPTFSVLLKNVPCGGGA-TCLKSVKVELNGD 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076    972 ELKLSHGKVEVIGTDESQEVPYT-------IRQMGIYLVVDTDIGLV-LLWDKKTSIFINLSPEFKGRVCGLCGNFDDIA 1043
Cdd:smart00216   75 EIELKDDNGKVTVNGQQVSLPYKtsdgsiqIRSSGGYLVVITSLGLIqVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEP 154


                    ....*...
gi 748983076   1044 VNDFATRS 1051
Cdd:smart00216  155 EDDFRTPD 162
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 423-587 5.59e-37

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 139.07  E-value: 5.59e-37
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076    423 WSCQEVPCPGTCSVLGGAHFSTFDGKQYTVHGDCSYVLTKPCDSS-AFTVLAELRRCGltDSETCLKSVTLSLDGaQTVV 501
Cdd:smart00216    1 WCCTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSEpTFSVLLKNVPCG--GGATCLKSVKVELNG-DEIE 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076    502 VIKASGEVFLNQIYTQLPISAANVTI-FRPSTFFIIAQTSLGLqLNLQLVPTMQLFMQLAPKLRGQTCGLCGNFNSIQAD 580
Cdd:smart00216   78 LKDDNGKVTVNGQQVSLPYKTSDGSIqIRSSGGYLVVITSLGL-IQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPED 156


                    ....*..
gi 748983076    581 DFRTLSG 587
Cdd:smart00216  157 DFRTPDG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 434-588 1.83e-34

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 131.34  E-value: 1.83e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076   434 CSVLGGAHFSTFDGKQYTVHGDCSYVLTKPCDS-SAFTVLAELRRCGLTDSETCLKSVTLSLDGaqTVVVIKASGEVFLN 512
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEePDFSFSVTNKNCNGGASGVCLKSVTVIVGD--LEITLQKGGTVLVN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 748983076   513 QIYTQLPISAANVTIFRPSTFFIIAQTSLGLQLNLQLVPTMQLFMQLAPKLRGQTCGLCGNFNSIQADDFRTLSGV 588
Cdd:pfam00094   79 GQKVSLPYKSDGGEVEILGSGFVVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 903-1051 2.50e-32

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 125.18  E-value: 2.50e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076   903 CAVYGDGHYLTFDGQSYSFNGDCEYTLVQNhCGGkdSTQDSFRVVTENVPCGTTGTtCSKAIKIFLGGFELKLSHGKVEV 982
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKD-CSE--EPDFSFSVTNKNCNGGASGV-CLKSVTVIVGDLEITLQKGGTVL 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 748983076   983 IGTDESqEVPYT-----IRQMG---IYLVVDTDIGLVLLWDKKTSIFINLSPEFKGRVCGLCGNFDDIAVNDFATRS 1051
Cdd:pfam00094   77 VNGQKV-SLPYKsdggeVEILGsgfVVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPD 152
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 1389-1475 3.07e-31

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 119.36  E-value: 3.07e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  1389 WSPWMDVSRPGrGTDSGDFDTLENLRAHGyRVCESPRSVECRAEDAPGVPLRALGQRVQCSPDVGLTCRNREQASGLCYN 1468
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENPTDIECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPDGCLD 78


                   ....*..
gi 748983076  1469 YQIRVQC 1475
Cdd:pfam13330   79 YEVRFLC 85
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 4921-5080 4.45e-30

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 118.63  E-value: 4.45e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  4921 CSGWGDPHYITFDGTYYTFLDNCTYVLVqQIVPVYGHFRVLVDNYFCGAEDGLSCPRSIILEYHQDRVVLTRkpvhgvmT 5000
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLA-KDCSEEPDFSFSVTNKNCNGGASGVCLKSVTVIVGDLEITLQK-------G 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  5001 NEIIFNNKVVSPGFRKNGIVVSRIGVKMYATIPELGVQVMFSGL-IFSVEVPFSKFANN-TEGQCGTCTNDRKDECRTPR 5078
Cdd:pfam00094   73 GTVLVNGQKVSLPYKSDGGEVEILGSGFVVVDLSPGVGLQVDGDgRGQLFVTLSPSYQGkTCGLCGNYNGNQEDDFMTPD 152


                   ..
gi 748983076  5079 GT 5080
Cdd:pfam00094  153 GT 154
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 1584-1670 2.53e-29

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 113.97  E-value: 2.53e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  1584 WTEWIDGSYPApGINGGDFDTFQNLRDEGyTFCESPRSVQCRAESFPNTPLADLGQDVICSHTEGLICLNKNQLPPICYN 1663
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENPTDIECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPDGCLD 78


                   ....*..
gi 748983076  1664 YEIRIQC 1670
Cdd:pfam13330   79 YEVRFLC 85
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 1957-2043 2.53e-29

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 113.97  E-value: 2.53e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  1957 WTEWIDGSYPApGINGGDFDTFQNLRDEGyTFCESPRSVQCRAESFPNTPLADLGQDVICSHTEGLICLNKNQLPPICYN 2036
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENPTDIECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPDGCLD 78


                   ....*..
gi 748983076  2037 YEIRIQC 2043
Cdd:pfam13330   79 YEVRFLC 85
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 3959-4050 2.71e-29

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 113.97  E-value: 2.71e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  3959 WTKWFDVDFPSpGPHGGDKETYNNIIRSGeKICRRPEEItrlQCRAESHPEVSIEHLGQVVQCSREEGLVCRNQDQQGPf 4038
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENPTDI---ECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPD- 74

                           90
                   ....*....|..
gi 748983076  4039 kMCLNYEVRVLC 4050
Cdd:pfam13330   75 -GCLDYEVRFLC 85
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 4633-4724 3.69e-29

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 113.58  E-value: 3.69e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  4633 WTKWFDVDFPSpGPHGGDKETYNNIIRSGeKICRRPEEItrlQCRAESHPEVNIEHLGQVVQCSREEGLVCRNQDQQGPf 4712
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENPTDI---ECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPD- 74

                           90
                   ....*....|..
gi 748983076  4713 kMCLNYEVRVLC 4724
Cdd:pfam13330   75 -GCLDYEVRFLC 85
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 1749-1840 6.18e-29

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 112.81  E-value: 6.18e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  1749 WTKWFDVDFPSpGPHGGDKETYNNIIRSGeKICRRPEEItrlQCRAKSHPEVSIEHLGQVVQCSREEGLVCRNQDQQGPf 1828
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENPTDI---ECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPD- 74

                           90
                   ....*....|..
gi 748983076  1829 kMCLNYEVRVLC 1840
Cdd:pfam13330   75 -GCLDYEVRFLC 85
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 3526-3617 6.18e-29

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 112.81  E-value: 6.18e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  3526 WTKWFDVDFPSpGPHGGDKETYNNIIRSGeKICRRPEEItrlQCRAKSHPEVSIEHLGQVVQCSREEGLVCRNQDQQGPf 3605
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENPTDI---ECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPD- 74

                           90
                   ....*....|..
gi 748983076  3606 kMCLNYEVRVLC 3617
Cdd:pfam13330   75 -GCLDYEVRFLC 85
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 2122-2213 6.43e-29

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 112.81  E-value: 6.43e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  2122 WTTWFDVDFPSpGPHGGDKETYNNIIRSGeKICRRPEEItrlQCRAKSHPEVSIEHLGQVVQCSREEGLVCRNQDQQGPf 2201
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENPTDI---ECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPD- 74

                           90
                   ....*....|..
gi 748983076  2202 kMCLNYEVRVLC 2213
Cdd:pfam13330   75 -GCLDYEVRFLC 85
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 3228-3319 7.15e-29

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 112.81  E-value: 7.15e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  3228 WTKWFDIDFPSpGPHGGDKETYNNIIRSGeKICRRPEEItrlQCRAESHPEVSIEHLGQVVQCSREEGLVCRNQDQQGPf 3307
Cdd:pfam13330    1 WTPWFDVDNPS-GSGGGDFETLENLRAYG-KFCENPTDI---ECRAEPPTGVPASETGQVVTCDVTTGLVCRNADQQPD- 74

                           90
                   ....*....|..
gi 748983076  3308 kMCLNYEVRVLC 3319
Cdd:pfam13330   75 -GCLDYEVRFLC 85
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 74-216 1.02e-28

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 115.19  E-value: 1.02e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076     74 PAHNGRVCSTWGSFHYKTFDGDVFRFPGLCNYVFSEHCGaAYEDFNIQLRRSQESAAPT-LSRVLMKVDGVVIQLTK--G 150
Cdd:smart00216    5 QEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCS-SEPTFSVLLKNVPCGGGATcLKSVKVELNGDEIELKDdnG 83

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 748983076    151 SVLVNGHPVLLPFSQSGVLIQQSSS--YTKVEARLGLV-LMWNHDDSLLLELDTKYANKTCGLCGDFNG 216
Cdd:smart00216   84 KVTVNGQQVSLPYKTSDGSIQIRSSggYLVVITSLGLIqVTFDGLTLLSVQLPSKYRGKTCGLCGNFDG 152
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 81-218 5.96e-27

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 109.77  E-value: 5.96e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076    81 CSTWGSFHYKTFDGDVFRFPGLCNYVFSEHCGAAYED-FNIQLRRSQESA-APTLSRVLMKVDGVVIQLTKG-SVLVNGH 157
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPDFsFSVTNKNCNGGAsGVCLKSVTVIVGDLEITLQKGgTVLVNGQ 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 748983076   158 PVLLPFSQSGVLIQQSSSY---TKVEARLGLVLMWNHDDSLLLELDTKYANKTCGLCGDFNGMP 218
Cdd:pfam00094   81 KVSLPYKSDGGEVEILGSGfvvVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQ 144
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 624-694 4.78e-25

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 101.65  E-value: 4.78e-25
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 748983076    624 EKYAQHWCSQLTDADGPFGRCHAAVKPGTYYSNCMFDTCNCERSEDCLCAALSSYVHACAAKGVQLGGWRD 694
Cdd:smart00832    1 KYYACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRT 71
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1088-1162 2.65e-24

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 99.34  E-value: 2.65e-24
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 748983076   1088 KSWAQKQCSILHGP--TFAACHAHVEPARYYEACVNDACACdsGGDCECFCTAVAAYAQACHEVGLCVS-WRTPSICP 1162
Cdd:smart00832    1 KYYACSQCGILLSPrgPFAACHSVVDPEPFFENCVYDTCAC--GGDCECLCDALAAYAAACAEAGVCISpWRTPTFCP 76
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 630-693 6.24e-20

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 86.67  E-value: 6.24e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 748983076   630 WCSQLTDaDGPFGRCHAAVKPGTYYSNCMFDTCNCERSEDCLCAALSSYVHACAAKGVQLGGWR 693
Cdd:pfam08742    1 KCGLLSD-SGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWR 63
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1094-1161 4.25e-19

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 84.35  E-value: 4.25e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076  1094 QCSIL-HGPTFAACHAHVEPARYYEACVNDACACdsGGDCECFCTAVAAYAQACHEVGLCV-SWRTPSIC 1161
Cdd:pfam08742    1 KCGLLsDSGPFAPCHSVVDPEPYFEACVYDMCSC--GGDDECLCAALAAYARACQAAGVCIgDWRTPTFC 68
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 5534-5616 2.68e-18

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 82.45  E-value: 2.68e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076   5534 VYHRSLIIQQQGCSSSEpVRLAYCRGNCGDSSSmysLEGNTVEHRCQCCQELRTSLRNVTLHCTDGSSRAFSYTEVEECG 5613
Cdd:smart00041    1 KSPVRQTITYNGCTSVT-VKNAFCEGKCGSASS---YSIQDVQHSCSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECG 76


                    ...
gi 748983076   5614 CMG 5616
Cdd:smart00041   77 CEP 79
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 265-334 1.03e-14

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 71.64  E-value: 1.03e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076   265 ICEELLHGQLFSGCVALVDVGSYLEACRQDLCFCEDTDllSCVCHTLAEYSRQCTHAGGLPQDWRGPDFC 334
Cdd:pfam08742    1 KCGLLSDSGPFAPCHSVVDPEPYFEACVYDMCSCGGDD--ECLCAALAAYARACQAAGVCIGDWRTPTFC 68
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 338-394 2.41e-14

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 70.42  E-value: 2.41e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 748983076  338 CPNNMQYHECRSPCADTCSNQEHSRACEDHCVAGCFCPEGTVLDDIGQtgCVPVSKC 394
Cdd:cd19941     1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNSGGK--CVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 338-394 1.52e-12

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 65.10  E-value: 1.52e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 748983076   338 CPNNMQYHECRSPCADTCSNQEHSRACEDHCVAGCFCPEGTVLDDIGQtgCVPVSKC 394
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVCPEPCVEGCVCPPGFVRNSGGK--CVPPSDC 55
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 5146-5205 2.95e-10

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 59.32  E-value: 2.95e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 748983076  5146 ICQLILSK-VFEPCHTVIPPLLFYEGCVFDRCHMT-DLDVVCSSLELYAALCASHDICI-DWR 5205
Cdd:pfam08742    1 KCGLLSDSgPFAPCHSVVDPEPYFEACVYDMCSCGgDDECLCAALAAYARACQAAGVCIgDWR 63
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 275-335 7.44e-10

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 58.12  E-value: 7.44e-10
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 748983076    275 FSGCVALVDVGSYLEACRQDLCFCEDTDLlsCVCHTLAEYSRQCTHAGGLPQDWRGPDFCP 335
Cdd:smart00832   18 FAACHSVVDPEPFFENCVYDTCACGGDCE--CLCDALAAYAAACAEAGVCISPWRTPTFCP 76
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 5147-5213 1.31e-09

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 57.74  E-value: 1.31e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 748983076   5147 CQLILSK--VFEPCHTVIPPLLFYEGCVFDRC-HMTDLDVVCSSLELYAALCASHDICI-DWRGRTghMCP 5213
Cdd:smart00832    8 CGILLSPrgPFAACHSVVDPEPFFENCVYDTCaCGGDCECLCDALAAYAAACAEAGVCIsPWRTPT--FCP 76
VWC_out smart00215
von Willebrand factor (vWF) type C domain;
396-464 9.91e-09

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214565  Cd Length: 67  Bit Score: 54.88  E-value: 9.91e-09
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 748983076    396 CVYNGAAYAPGATYSTDCTNCTCSGGRWSCQEVPCPGTCSVLGGAHFSTFDGKQytVHGDCSYVLTKPC 464
Cdd:smart00215    1 CWNNGSYYPPGAKWDDDCNRCTCLNGRVSCTKVWCGPKPCLLHNLSGECPLGQG--CVPSLSDCLSSPC 67
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 802-863 5.42e-06

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 46.54  E-value: 5.42e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 748983076  802 CAAPMVFFDCrnatpgdtGAGCQKSCHTLD--MTCySPQCVPGCVCPDGLVADGEGGCITAEDC 863
Cdd:cd19941     1 CPPNEVYSEC--------GSACPPTCANPNapPPC-TKQCVEGCFCPEGYVRNSGGKCVPPSQC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 704-761 1.87e-05

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 45.00  E-value: 1.87e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 748983076  704 CPKSMTYHYHVSTCQPTCRSLsEGDITCSVGFIPvdGCICPKGTFLDDTGKCVQASNC 761
Cdd:cd19941     1 CPPNEVYSECGSACPPTCANP-NAPPPCTKQCVE--GCFCPEGYVRNSGGKCVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 802-863 3.10e-04

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 41.60  E-value: 3.10e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 748983076   802 CAAPMVFFDCrnatpgdtGAGCQKSCHTL--DMTCySPQCVPGCVCPDGLVADGEGGCITAEDC 863
Cdd:pfam01826    1 CPANEVYSEC--------GSACPPTCANLspPDVC-PEPCVEGCVCPPGFVRNSGGKCVPPSDC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 704-761 6.23e-04

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 40.83  E-value: 6.23e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 748983076   704 CPKSMTYHYHVSTCQPTCRSLSEGDI---TCsvgfipVDGCICPKGTFLDDTGKCVQASNC 761
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVcpePC------VEGCVCPPGFVRNSGGKCVPPSDC 55
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1335-1576 5.85e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 5.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076 1335 PLVVSSTHTPSNGPSSAH-------------TGPPSSAWPTTAGTSPRTRLPTASASLPPVCGEKCLWSPWMD------- 1394
Cdd:PHA03247 2580 PAVTSRARRPDAPPQSARprapvddrgdprgPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPrddpapg 2659

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076 1395 -VSRPGR----GTDSGDFDTLENLRAHGYRVCESPRSVECRAEDAPGVPLRALGQRVQCSPDVGLTCRNREQASGlcyny 1469
Cdd:PHA03247 2660 rVSRPRRarrlGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPA----- 2734

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076 1470 qirvqccTPLPCSTSSSPAQTTPPTTSKTTETRASGSSAPSSTPGTVSLST-ARTTPAPGTATSVKKTFSTPSPPPvPAT 1548
Cdd:PHA03247 2735 -------LPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGpPRRLTRPAVASLSESRESLPSPWD-PAD 2806

                         250       260
                  ....*....|....*....|....*...
gi 748983076 1549 STSSMSTTAPGTSVVSSKPTPTEPSTSS 1576
Cdd:PHA03247 2807 PPAAVLAPAAALPPAASPAGPLPPPTSA 2834
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1335-1576 6.23e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.24  E-value: 6.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076 1335 PLVVSSTHTPSNGPSSAhtgPPSSAWPTTAGTSPRTRLPTASASLPPVCGekclwSPWMDVSRPGRGTDSGDFDTLENLR 1414
Cdd:PHA03307  177 SSPEETARAPSSPPAEP---PPSTPPAAASPRPPRRSSPISASASSPAPA-----PGRSAADDAGASSSDSSSSESSGCG 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076 1415 AHGYRVCESPRSVECRAEDAPGVPLRALGQRVQCSPdvgltcrnREQASGlcynyqIRVQCCTPLPCSTSSSPAQTTPPT 1494
Cdd:PHA03307  249 WGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGP--------ASSSSS------PRERSPSPSPSSPGSGPAPSSPRA 314

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983076 1495 TSKTTETRASGSSAPSSTPGTVSLSTARTTPAPGTATSVkktfSTPSPPPVPATSTSSMSTTAPGTSVVSSKPTPTEPST 1574
Cdd:PHA03307  315 SSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSP----SRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRA 390


                  ..
gi 748983076 1575 SS 1576
Cdd:PHA03307  391 RA 392
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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