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Conserved domains on  [gi|698980052|ref|NP_001289319|]
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phospholipid phosphatase 2 isoform 3 [Mus musculus]

Protein Classification

PAP2 phosphatase family protein( domain architecture ID 10130187)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to phospholipid phosphatase that catalyzes the conversion of phosphatidic acid to diacylglycerol

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 1-121 6.85e-62

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


:

Pssm-ID: 239479  Cd Length: 150  Bit Score: 187.45  E-value: 6.85e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698980052   1 MIGRLRPSFLAVCDPDWSQVNCSGYVQLEV----CRGSPANVTEARLSFYSGHSSFGMYCMLFLALYVQARLCWKWARLL 76
Cdd:cd03384   26 VTGRLRPHFLDVCKPNYTDLTCSLDHQYIAdctcCTGDPDLIREARLSFPSGHASLSMYAAVFLALYLQARLKLRGSRLL 105

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 698980052  77 RPTVQFFLVAFAIYVGYTRVSDHKHHWSDVLVGLLQGALVACLTV 121
Cdd:cd03384  106 RPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
 
Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 1-121 6.85e-62

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 187.45  E-value: 6.85e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698980052   1 MIGRLRPSFLAVCDPDWSQVNCSGYVQLEV----CRGSPANVTEARLSFYSGHSSFGMYCMLFLALYVQARLCWKWARLL 76
Cdd:cd03384   26 VTGRLRPHFLDVCKPNYTDLTCSLDHQYIAdctcCTGDPDLIREARLSFPSGHASLSMYAAVFLALYLQARLKLRGSRLL 105

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 698980052  77 RPTVQFFLVAFAIYVGYTRVSDHKHHWSDVLVGLLQGALVACLTV 121
Cdd:cd03384  106 RPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
acidPPc smart00014
Acid phosphatase homologues;
1-121 1.68e-23

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 88.56  E-value: 1.68e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698980052     1 MIGRLRPSFLAVCDPdwsqvncsgyvqleVCRGSPANVTEARLSFYSGHSSFGMYCMLFLALYvqarlcwKWARLLRPTV 80
Cdd:smart00014  17 YFGRPRPFFLSIGDA--------------CCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLY-------LPARAGRKLL 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 698980052    81 QFFLVAFAIYVGYTRVSDHKHHWSDVLVGLLQGALVACLTV 121
Cdd:smart00014  76 IFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 2-124 2.65e-19

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 78.23  E-value: 2.65e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698980052    2 IGRLRPSFLAVCDPDWSQvncsgyvqlevcrgsPANVTEARLSFYSGHSSFGMYCMLFLALYVqARLCWKWARLLRptvq 81
Cdd:pfam01569  20 FGRPRPFFLLLEGGLVPA---------------PSTLPGLGYSFPSGHSATAFALALLLALLL-RRLRKIVRVLLA---- 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 698980052   82 FFLVAFAIYVGYTRVSDHKHHWSDVLVGLLQGALVACLTVRYV 124
Cdd:pfam01569  80 LLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLV 122
PLN02715 PLN02715
lipid phosphate phosphatase
 3-122 7.29e-14

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 67.39  E-value: 7.29e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698980052   3 GRLRPSFLAVCDPDWSQV-NCSGYVqleVCRGSPANVTEARLSFYSGHSSFGMYCMLFLALYVQARLCW--KWARLLRPT 79
Cdd:PLN02715 147 GRPRPNFYWRCFPDGKELyDALGGV---ICHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLSGKIKAfnGEGHVAKLC 223

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 698980052  80 VQFFLVAFAIYVGYTRVSDHKHHWSDVLVGLLQGALVACLTVR 122
Cdd:PLN02715 224 LVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGILVAAFCYR 266
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 30-124 1.03e-07

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 48.88  E-value: 1.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698980052  30 VCRGSPANVTEARLSFYSGHSSFGMYCMLFLALYVQARLCWkwarllrptvqFFLVAFAIYVGYTRVSDHKHHWSDVLVG 109
Cdd:COG0671  104 VPDLELLLGTAGGYSFPSGHAAAAFALALVLALLLPRRWLA-----------ALLLALALLVGLSRVYLGVHYPSDVLAG 172

                         90
                 ....*....|....*
gi 698980052 110 LLQGALVACLTVRYV 124
Cdd:COG0671  173 ALLGLAIALLLLALL 187
 
Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 1-121 6.85e-62

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 187.45  E-value: 6.85e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698980052   1 MIGRLRPSFLAVCDPDWSQVNCSGYVQLEV----CRGSPANVTEARLSFYSGHSSFGMYCMLFLALYVQARLCWKWARLL 76
Cdd:cd03384   26 VTGRLRPHFLDVCKPNYTDLTCSLDHQYIAdctcCTGDPDLIREARLSFPSGHASLSMYAAVFLALYLQARLKLRGSRLL 105

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 698980052  77 RPTVQFFLVAFAIYVGYTRVSDHKHHWSDVLVGLLQGALVACLTV 121
Cdd:cd03384  106 RPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 2-124 6.27e-27

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 99.60  E-value: 6.27e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698980052   2 IGRLRPSFLAVCDPDWSQVNCSGYVQLEVCRGSPANVTEARLSFYSGHSSFGMYCMLFLALYVQARL-CWKWA-RLLRPT 79
Cdd:cd03390   69 AGRPRPDFLARCFPDGGTPSDTLVGIDICCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLhIFDPRgSSWRLL 148

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 698980052  80 VQFFLVAFAIYVGYTRVSDHKHHWSDVLVGLLQGALVACLTVRYV 124
Cdd:cd03390  149 LALLPLLLAILVAVSRTRDYRHHFSDVIAGSLIGLIIAYLSYRQY 193
acidPPc smart00014
Acid phosphatase homologues;
1-121 1.68e-23

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 88.56  E-value: 1.68e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698980052     1 MIGRLRPSFLAVCDPdwsqvncsgyvqleVCRGSPANVTEARLSFYSGHSSFGMYCMLFLALYvqarlcwKWARLLRPTV 80
Cdd:smart00014  17 YFGRPRPFFLSIGDA--------------CCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLY-------LPARAGRKLL 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 698980052    81 QFFLVAFAIYVGYTRVSDHKHHWSDVLVGLLQGALVACLTV 121
Cdd:smart00014  76 IFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 1-121 4.01e-20

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 80.20  E-value: 4.01e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698980052   1 MIGRLRPSFLAVCDPDwsqvncsgyvqlevcrGSPANVTEARLSFYSGHSSFGMYCMLFLALYVqarlcwkWARLLRPTV 80
Cdd:cd01610   25 LFGRPRPYFLLRCGPD----------------GDPLLLTEGGYSFPSGHAAFAFALALFLALLL-------PRRLLRLLL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 698980052  81 QFFLVAFAIYVGYTRVSDHKHHWSDVLVGLLQGALVACLTV 121
Cdd:cd01610   82 GLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLVL 122
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 2-124 2.65e-19

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 78.23  E-value: 2.65e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698980052    2 IGRLRPSFLAVCDPDWSQvncsgyvqlevcrgsPANVTEARLSFYSGHSSFGMYCMLFLALYVqARLCWKWARLLRptvq 81
Cdd:pfam01569  20 FGRPRPFFLLLEGGLVPA---------------PSTLPGLGYSFPSGHSATAFALALLLALLL-RRLRKIVRVLLA---- 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 698980052   82 FFLVAFAIYVGYTRVSDHKHHWSDVLVGLLQGALVACLTVRYV 124
Cdd:pfam01569  80 LLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLV 122
PLN02715 PLN02715
lipid phosphate phosphatase
 3-122 7.29e-14

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 67.39  E-value: 7.29e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698980052   3 GRLRPSFLAVCDPDWSQV-NCSGYVqleVCRGSPANVTEARLSFYSGHSSFGMYCMLFLALYVQARLCW--KWARLLRPT 79
Cdd:PLN02715 147 GRPRPNFYWRCFPDGKELyDALGGV---ICHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLSGKIKAfnGEGHVAKLC 223

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 698980052  80 VQFFLVAFAIYVGYTRVSDHKHHWSDVLVGLLQGALVACLTVR 122
Cdd:PLN02715 224 LVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGILVAAFCYR 266
PLN02250 PLN02250
lipid phosphate phosphatase
 2-117 4.03e-12

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 62.25  E-value: 4.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698980052   2 IGRLRPSFLAVCDPDWSQV--NCSGYVqleVCRGSPANVTEARLSFYSGHSSFGMYCMLFLALYV--QARLCWKWARLLR 77
Cdd:PLN02250 121 VGRPRPDFFWRCFPDGKGVfhPVTTDV---LCTGAKSVIKEGHKSFPSGHTSWSFAGLGFLSLYLsgKIRVFDRRGHVAK 197

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 698980052  78 PTVQFFLVAFAIYVGYTRVSDHKHHWSDVLVGLLQGALVA 117
Cdd:PLN02250 198 LCIVFLPLLVAALVGVSRVDDYWHHWQDVFAGALIGLTVA 237
PLN02731 PLN02731
Putative lipid phosphate phosphatase
 2-113 2.93e-10

Putative lipid phosphate phosphatase


Pssm-ID: 178332  Cd Length: 333  Bit Score: 57.35  E-value: 2.93e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698980052   2 IGRLRPSFLAVCDPDWSQVNCS-GYVqleVCRGSPANVTEARLSFYSGHSSFGMYCMLFLALYVQARLCW--KWARLLRP 78
Cdd:PLN02731 140 VGRPRPDFFWRCFPDGKALYDSlGDV---ICHGDKSVIREGHKSFPSGHTSWSFSGLGFLSLYLSGKIQAfdGKGHVAKL 216

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 698980052  79 TVQFFLVAFAIYVGYTRVSDHKHHWSDVLVGLLQG 113
Cdd:PLN02731 217 CIVILPLLFAALVGISRVDDYWHHWQDVFAGGLLG 251
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 43-124 7.24e-10

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 53.10  E-value: 7.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698980052  43 LSFYSGHSSFGMYCmlflALYVQARLCWKWarllrptVQFFLVAFAIYVGYTRVSDHKHHWSDVLVgllqGALVACLTVR 122
Cdd:cd03394   39 RSFPSGHTASAFAA----ATFLQYRYGWRW-------YGIPAYALASLVGASRVVANRHWLSDVLA----GAAIGILVGY 103


                 ..
gi 698980052 123 YV 124
Cdd:cd03394  104 LV 105
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 30-124 1.03e-07

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 48.88  E-value: 1.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698980052  30 VCRGSPANVTEARLSFYSGHSSFGMYCMLFLALYVQARLCWkwarllrptvqFFLVAFAIYVGYTRVSDHKHHWSDVLVG 109
Cdd:COG0671  104 VPDLELLLGTAGGYSFPSGHAAAAFALALVLALLLPRRWLA-----------ALLLALALLVGLSRVYLGVHYPSDVLAG 172

                         90
                 ....*....|....*
gi 698980052 110 LLQGALVACLTVRYV 124
Cdd:COG0671  173 ALLGLAIALLLLALL 187
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 47-117 3.68e-05

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 41.49  E-value: 3.68e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 698980052  47 SGHSSFgmycMLFLALYVQARLCWKWARLLRPTVQFFLVAF----AIYVGYTRVSDHKHHWSDVLVGLLQGALVA 117
Cdd:cd03382   85 SSHSQF----MGFFAVYLLLFIYLRLGRLNSLVSRFLLSLGllllALLVSYSRVYLGYHTVSQVVVGAIVGILLG 155
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 2-122 4.51e-04

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 38.78  E-value: 4.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698980052   2 IGRLRPSF-LAVCDPDWSQVNCSGYvqlevcrgspanvtearlSFYSGHSSFGMYCMLFLALYVqarlcwkWARLLRPtv 80
Cdd:cd03395   80 VARLRPCNaLDGVRLVVLGDQGGSY------------------SFASSHAANSFALALFIWLFF-------RRGLFSP-- 132

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 698980052  81 qfFLVAFAIYVGYTRVSDHKHHWSDVLVGLLQGALVACLTVR 122
Cdd:cd03395  133 --VLLLWALLVGYSRVYVGVHYPGDVIAGALIGIISGLLFYL 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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