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Conserved domains on  [gi|667667686|ref|NP_001288088|]
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NHL-repeat-containing protein 4 [Homo sapiens]

Protein Classification

NHL repeat-containing protein( domain architecture ID 110303)

NHL (NCL-1, HT2A and LIN-41) repeat-containing protein may have a catalytic activity or interact with other proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 3-117 6.07e-20

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd14961:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 273  Bit Score: 81.94  E-value: 6.07e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667686   3 GLEGPCWVGPGPDGGLAVSEEFGD---------VRLFGSARQPLGSLggwtgHTFG---------CPAGICSNSEGNVIV 64
Cdd:cd14961  143 QLCRPRFVAVSRLGAVAVTEHLFAngtrssstrVKVFSSGGQLLGQI-----DSFGlnlvfpsliCASGVAFDSEGNVIV 217

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 667667686  65 ADEQRRQVTLFPRAGP-PIC--LVSEGLGQPLGVACAPQGQLLVADAKDNSIKVYQ 117
Cdd:cd14961  218 ADTGSGAILCLGKPEGfPILkpIVTQGLSRPVGLAVTPDGSLVVLDSGNHCVKIYK 273
 
Name Accession Description Interval E-value
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 3-117 6.07e-20

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 81.94  E-value: 6.07e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667686   3 GLEGPCWVGPGPDGGLAVSEEFGD---------VRLFGSARQPLGSLggwtgHTFG---------CPAGICSNSEGNVIV 64
Cdd:cd14961  143 QLCRPRFVAVSRLGAVAVTEHLFAngtrssstrVKVFSSGGQLLGQI-----DSFGlnlvfpsliCASGVAFDSEGNVIV 217

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 667667686  65 ADEQRRQVTLFPRAGP-PIC--LVSEGLGQPLGVACAPQGQLLVADAKDNSIKVYQ 117
Cdd:cd14961  218 ADTGSGAILCLGKPEGfPILkpIVTQGLSRPVGLAVTPDGSLVVLDSGNHCVKIYK 273
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
6-113 6.36e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 35.00  E-value: 6.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667686   6 GPCWVGPGPDGGLAVSEEFGD-VRLFGSARqplGSLGGWTGHTFGCPAGICSNSEGNVIVADEQRRQVTLF-PRAGPPIC 83
Cdd:COG4257   18 GPRDVAVDPDGAVWFTDQGGGrIGRLDPAT---GEFTEYPLGGGSGPHGIAVDPDGNLWFTDNGNNRIGRIdPKTGEITT 94

                         90       100       110
                 ....*....|....*....|....*....|.
gi 667667686  84 LVSEGLG-QPLGVACAPQGQLLVADAKDNSI 113
Cdd:COG4257   95 FALPGGGsNPHGIAFDPDGNLWFTDQGGNRI 125
 
Name Accession Description Interval E-value
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 3-117 6.07e-20

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 81.94  E-value: 6.07e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667686   3 GLEGPCWVGPGPDGGLAVSEEFGD---------VRLFGSARQPLGSLggwtgHTFG---------CPAGICSNSEGNVIV 64
Cdd:cd14961  143 QLCRPRFVAVSRLGAVAVTEHLFAngtrssstrVKVFSSGGQLLGQI-----DSFGlnlvfpsliCASGVAFDSEGNVIV 217

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 667667686  65 ADEQRRQVTLFPRAGP-PIC--LVSEGLGQPLGVACAPQGQLLVADAKDNSIKVYQ 117
Cdd:cd14961  218 ADTGSGAILCLGKPEGfPILkpIVTQGLSRPVGLAVTPDGSLVVLDSGNHCVKIYK 273
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 3-116 2.37e-13

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 64.26  E-value: 2.37e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667686   3 GLEGPCWVGPGPDGGLAVSEEFGD-VRLFGSARQPLGSLG--GWTGHTFGCPAGICSNSEGNVIVADEQRRQVTLFPRAG 79
Cdd:cd05819  147 QFNGPTGVAVDSDGNIYVADTGNHrIQVFDPDGNFLTTFGstGTGPGQFNYPTGIAVDSDGNIYVADSGNNRVQVFDPDG 226

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 667667686  80 PPIC------LVSEGLGQPLGVACAPQGQLLVADAKDNSIKVY 116
Cdd:cd05819  227 AGFGgngnflGSDGQFNRPSGLAVDSDGNLYVADTGNNRIQVF 269
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 38-116 8.73e-12

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 59.98  E-value: 8.73e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667686  38 GSLGGWTGhTFGCPAGICSNSEGNVIVADEQRRQVTLFPRAGP------PICLVSEGLGQPLGVACAPQGQLLVADAKDN 111
Cdd:cd14961    1 GSFGGWPG-TLNNPTGVAVTPTGRVVVADDGNKRIQVFDSDGNclqqfgPKGDAGQDIRYPLDVAVTPDGHIVVTDAGDR 79


                 ....*
gi 667667686 112 SIKVY 116
Cdd:cd14961   80 SVKVF 84
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 48-116 6.90e-09

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 51.94  E-value: 6.90e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 667667686  48 FGCPAGICSNSEGNVIVADEQRRQVTLFPRAGPPICLVSE---GLGQ---PLGVACAPQGQLLVADAKDNSIKVY 116
Cdd:cd05819    7 LNNPQGIAVDSSGNIYVADTGNNRIQVFDPDGNFITSFGSfgsGDGQfnePAGVAVDSDGNLYVADTGNHRIQKF 81
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 4-116 4.32e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 49.62  E-value: 4.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667686   4 LEGPCWVGPGPDGGLAVSEEFGD-VRLFGSARQPLGSLG--GWTGHTFGCPAGICSNSEGNVIVADEQRRQVTLFPRAGP 80
Cdd:cd05819   54 FNEPAGVAVDSDGNLYVADTGNHrIQKFDPDGNFLASFGgsGDGDGEFNGPRGIAVDSSGNIYVADTGNHRIQKFDPDGE 133

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 667667686  81 PI-CLVSEGLG-----QPLGVACAPQGQLLVADAKDNSIKVY 116
Cdd:cd05819  134 FLtTFGSGGSGpgqfnGPTGVAVDSDGNIYVADTGNHRIQVF 175
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 3-116 7.83e-08

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 49.08  E-value: 7.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667686   3 GLEGPCWVGPGPDGGLAVSEeFGDVRL--FGSARQPLGSLG--GWTGHTFGCPAGICSNSEGNVIVADEQRRQVTLFPRA 78
Cdd:cd14954  163 QLDSPRGVAVNPDGNIVVSD-FNNHRLqvFDPDGQFLRFFGseGSGNGQFKRPRGVAVDDEGNIIVADSGNHRVQVFSPD 241

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 667667686  79 GPPICLV---SEGLGQ---PLGVACAPQGQLLVADAKDNSIKVY 116
Cdd:cd14954  242 GEFLCSFgteGNGEGQfdrPSGVAVTPDGRIVVVDRGNHRIQVF 285
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 4-116 8.52e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 48.85  E-value: 8.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667686   4 LEGPCWVGPGPDGGLAVSEEFGD-VRLFGSARQPLGSLG--GWTGHTFGCPAGICSNSEGNVIVADEQRRQVTLFPRAGP 80
Cdd:cd05819    7 LNNPQGIAVDSSGNIYVADTGNNrIQVFDPDGNFITSFGsfGSGDGQFNEPAGVAVDSDGNLYVADTGNHRIQKFDPDGN 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 667667686  81 PICLVS------EGLGQPLGVACAPQGQLLVADAKDNSIKVY 116
Cdd:cd05819   87 FLASFGgsgdgdGEFNGPRGIAVDSSGNIYVADTGNHRIQKF 128
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 38-111 2.06e-07

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 47.54  E-value: 2.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667686  38 GSLGGWTGHtFGCPAGICSNSEGNVIVADEQRRQVTLFPRAGPPIC-LVSEGLG-----QPLGVACAPQGQLLVADaKDN 111
Cdd:cd14954   61 GSYGSRDGQ-FDRPAGVAVNSRGRIIVADKDNHRIQVFDLNGRFLLkFGERGTKngqfnYPWGVAVDSEGRIYVSD-TRN 138
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 27-118 2.41e-07

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 47.54  E-value: 2.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667686  27 VRLFGSARQPL---GSLGGWTGHtFGCPAGICSNSEGNVIVADEQRRQVTLFPRAGPPI-CLVSEGLGQ-----PLGVAC 97
Cdd:cd14954  141 VQVFDSDGQFIrkfGFEGAGPGQ-LDSPRGVAVNPDGNIVVSDFNNHRLQVFDPDGQFLrFFGSEGSGNgqfkrPRGVAV 219

                         90       100
                 ....*....|....*....|.
gi 667667686  98 APQGQLLVADAKDNSIKVYQG 118
Cdd:cd14954  220 DDEGNIIVADSGNHRVQVFSP 240
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 45-111 2.40e-06

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 44.85  E-value: 2.40e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 667667686  45 GHTFGC---PAGICSNSEGNVIVADEQRRQVTLFPRAGPPICLVSE---GLGQ---PLGVACAPQGQLLVADaKDN 111
Cdd:cd14954   17 GSKDGElcrPWGVAVDKDGRIIVADRSNNRVQVFDPDGKFLRKFGSygsRDGQfdrPAGVAVNSRGRIIVAD-KDN 91
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 27-116 3.64e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 44.12  E-value: 3.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667686  27 VRLFGSARQPLGSLGGWTGHTFGCPAGICSNSEGNVIVADEQRRQVTLFPRAGPPICLVSEGLGQ--PLGVACAPQGQLL 104
Cdd:cd14962   35 VFVFDLPNGKVFVIGNAGPNRFVSPIGVAIDANGNLYVSDAELGKVFVFDRDGKFLRAIGAGALFkrPTGIAVDPAGKRL 114

                         90
                 ....*....|...
gi 667667686 105 -VADAKDNSIKVY 116
Cdd:cd14962  115 yVVDTLAHKVKVF 127
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 51-113 3.82e-06

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 44.19  E-value: 3.82e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 667667686  51 PAGICSNSEGNVIVADEQRRQVTLFPRAGPPICLVSEGLGQPLGVACAPQGQLLVADAKDNSI 113
Cdd:cd14961   60 PLDVAVTPDGHIVVTDAGDRSVKVFSFDGRLKLFVRKSFSLPWGVAVNPSGEILVTDSEAGKL 122
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 14-116 9.88e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 43.04  E-value: 9.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667686  14 PDGGLAVSEEFGD-VRLF---GSARQPLGSLGGWTGhTFGCPAGICSNSEGNVIVAD--EQRRQ--------VTLFPRAG 79
Cdd:cd14956   69 KDGWLYVADYWGDrIQVFtltGELQTIGGSSGSGPG-QFNAPRGVAVDADGNLYVADfgNQRIQkfdpdgsfLRQWGGTG 147

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 667667686  80 PPiclvSEGLGQPLGVACAPQGQLLVADAKDNSIKVY 116
Cdd:cd14956  148 IE----PGSFNYPRGVAVDPDGTLYVADTYNDRIQVF 180
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 4-116 1.77e-05

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 42.25  E-value: 1.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667686   4 LEGPCWVGPGPDGGLAVSEEFGD-VRLFGSARQPL---GSLGGWTGHtFGCPAGICSNSEGNVIVADEQRRQVTLFPRAG 79
Cdd:cd14957  111 FNGPYGIAVDSNGNIYVADTGNHrIQVFTSSGTFSysiGSGGTGPGQ-FNGPQGIAVDSDGNIYVADTGNHRIQVFTSSG 189

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 667667686  80 PPICLV-SEG-----LGQPLGVACAPQGQLLVADAKDNSIKVY 116
Cdd:cd14957  190 TFQYTFgSSGsgpgqFSDPYGIAVDSDGNIYVADTGNHRIQVF 232
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 13-117 2.76e-05

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 41.48  E-value: 2.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667686  13 GPDGGLAVSEEFGD-VRLFGSARQPLGSLGGWTGHT--FGCPAGICSNSEGNVIVADE--QRRQVtlFPRAG---PPICL 84
Cdd:cd14957  167 DSDGNIYVADTGNHrIQVFTSSGTFQYTFGSSGSGPgqFSDPYGIAVDSDGNIYVADTgnHRIQV--FTSSGayqYSIGT 244

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 667667686  85 VSEGLGQ---PLGVACAPQGQLLVADAKDNSIKVYQ 117
Cdd:cd14957  245 SGSGNGQfnyPYGIAVDNDGKIYVADSNNNRIQVFN 280
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 13-116 4.80e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 41.11  E-value: 4.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667686  13 GPDGGLAVSEeFGDVRL--FGSARQPLGSLGG---WTGHtFGCPAGICSNSEGNVIVAD--EQRRQVtlFPRAGPPICLV 85
Cdd:cd14956  115 DADGNLYVAD-FGNQRIqkFDPDGSFLRQWGGtgiEPGS-FNYPRGVAVDPDGTLYVADtyNDRIQV--FDNDGAFLRKW 190

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 667667686  86 SE---GLGQ---PLGVACAPQGQLLVADAKDNSIKVY 116
Cdd:cd14956  191 GGrgtGPGQfnyPYGIAIDPDGNVFVADFGNNRIQKF 227
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
 30-116 4.97e-05

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 40.79  E-value: 4.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667686  30 FGSARQPLGSLGGWTGhtfgcpagICSNSEGNVIVADEQRRQVTLFPRAGPPICLVSEGLGQ---PLGVACAPQGQLLVA 106
Cdd:cd14960  189 FGSNGEGNGQFNAPTG--------VAVDSNGNIIVADWGNSRIQVFDSSGSFLSYINTSADPlygPQGLALTSDGHVVVA 260

                         90
                 ....*....|
gi 667667686 107 DAKDNSIKVY 116
Cdd:cd14960  261 DSGNHCFKVY 270
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 15-116 8.83e-05

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 40.33  E-value: 8.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667686  15 DGGLAVSEEFGD-VRLFGSARQPLGSLGGWTGHT--FGCPAGICSNSEGNVIVADEQRRQVTLFPRAGP---PICLVSEG 88
Cdd:cd14957   28 AGNIYVADTGNNrIQVFTSSGVYSYSIGSGGTGSgqFNSPYGIAVDSNGNIYVADTDNNRIQVFNSSGVyqySIGTGGSG 107

                         90       100       110
                 ....*....|....*....|....*....|.
gi 667667686  89 LGQ---PLGVACAPQGQLLVADAKDNSIKVY 116
Cdd:cd14957  108 DGQfngPYGIAVDSNGNIYVADTGNHRIQVF 138
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 15-116 1.11e-04

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 39.94  E-value: 1.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667686  15 DGGLAVSEEFGD-VRLFGSARQPLGSLG-GWTGHT-FGCPAGICSNSEGNVIVADEQRRQVTLFPRAGPP---ICLVSEG 88
Cdd:cd14957   75 NGNIYVADTDNNrIQVFNSSGVYQYSIGtGGSGDGqFNGPYGIAVDSNGNIYVADTGNHRIQVFTSSGTFsysIGSGGTG 154

                         90       100       110
                 ....*....|....*....|....*....|.
gi 667667686  89 LGQ---PLGVACAPQGQLLVADAKDNSIKVY 116
Cdd:cd14957  155 PGQfngPQGIAVDSDGNIYVADTGNHRIQVF 185
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 51-115 1.39e-04

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 39.84  E-value: 1.39e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 667667686  51 PAGICSNSEGNVIVADEQRRQVTLFPRAGPPI-CLVSEG-----LGQPLGVACAPQGQLLVADAKDNSIKV 115
Cdd:cd14954  120 PWGVAVDSEGRIYVSDTRNHRVQVFDSDGQFIrKFGFEGagpgqLDSPRGVAVNPDGNIVVSDFNNHRLQV 190
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 47-116 1.59e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 39.58  E-value: 1.59e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 667667686  47 TFGCPAGICSNSEGNVIVADEQRRQVTLFPRAGPPIcLVSEGLGQ-------PLGVACAPQGQLLVADAKDNSIKVY 116
Cdd:cd14963  193 GFVNPRGIAVDPDGNLYVVDNLSHRVYVFDEQGKEL-FTFGGRGKddgqfnlPNGLFIDDDGRLYVTDRENNRVAVY 268
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 51-113 1.93e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 39.11  E-value: 1.93e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 667667686  51 PAGICSNSEGNVIVADE-QRRQVTLFPRAGPPICLVSEGLGQPLGVACAPQGQLLVADAKDNSI 113
Cdd:cd14952   54 PQGVAVDAAGTVYVTDFgNNRVLKLAAGSTTQTVLPFTGLNDPTGVAVDAAGNVYVADTGNNRV 117
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 45-116 2.08e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 39.11  E-value: 2.08e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 667667686  45 GHTFGCPAGICSNSEGNVIVADEQRRQVTLFPRAGPPICLVSEG----LGQPLGVACAPQGQLLVADAKDNSIKVY 116
Cdd:cd14962    8 KEALTRPYGVAADGRGRIYVADTGRGAVFVFDLPNGKVFVIGNAgpnrFVSPIGVAIDANGNLYVSDAELGKVFVF 83
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 48-116 4.51e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 38.04  E-value: 4.51e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 667667686  48 FGCPAGICSNSEGNVIVADEQRRQVTLFPRAGP-----PICLVSEGLGQPLGVACApQGQLLVADAKDNSIKVY 116
Cdd:cd14963   55 FKYPYGIAVDSDGNIYVADLYNGRIQVFDPDGKflkyfPEKKDRVKLISPAGLAID-DGKLYVSDVKKHKVIVF 127
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 51-116 5.06e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 38.04  E-value: 5.06e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 667667686  51 PAGICSNSEGNVIVADEQRRQVTLFPRAGPPICLVS------EGLGQPLGVACAPQGQLLVADAKDNSIKVY 116
Cdd:cd14963  150 PNGIAVDEDGNIYVADSGNGRIQVFDKNGKFIKELNgspdgkSGFVNPRGIAVDPDGNLYVVDNLSHRVYVF 221
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 51-111 1.21e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 36.80  E-value: 1.21e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 667667686  51 PAGICSNSEGNVIVADE-QRRQVTLFPRAGPPICLVSEGLGQPLGVACAPQGQLLVADAKDN 111
Cdd:cd14952   12 PGGVAVDAAGNVYVADSgNNRVLKLAAGSTTQTVLPFTGLYQPQGVAVDAAGTVYVTDFGNN 73
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 38-113 1.21e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 36.79  E-value: 1.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667686  38 GSLGGWTGHtFGCPAGICSNSEGNVIVADEQRRQVTLFPRAGPPIC-LVSEGLG-----QPLGVACAPQGQLLVADAKDN 111
Cdd:cd14955  194 GSEGSGDGQ-FNAPYGIAVDSAGNVYVADTGNNRIQKFDSSGTFITkWGSEGSGdgqfnSPSGIAVDSAGNVYVADSGNN 272


                 ..
gi 667667686 112 SI 113
Cdd:cd14955  273 RI 274
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 7-117 1.56e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 36.80  E-value: 1.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667686   7 PCWVGPGPDGGLAVSEEF-GDVRLFGSARQPLGSLG--GWTGHTFGCPAGICSNSEGNVIVADEQRRQVTLFPRAGP--- 80
Cdd:cd14962  150 PTDLAVDRDGNLYVTDTMnFRVQIFDADGKFLRSFGerGDGPGSFARPKGIAVDSEGNIYVVDAAFDNVQIFNPEGElll 229

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 667667686  81 PICLVSEGLGQ---PLGVACAPQGQLLVADAKDNSIKVYQ 117
Cdd:cd14962  230 TVGGPGSGPGEfylPSGIAIDKDDRIYVVDQFNRRIQVFQ 269
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 38-113 2.80e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 36.02  E-value: 2.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667686  38 GSLGGWTGHtFGCPAGICSNSEGNVIVADEQRRQVTLFPRAGPPICLV-SEGLG-----QPLGVACAPQGQLLVADAKDN 111
Cdd:cd14955  147 GSFGSGDGQ-FNSPTGIAVDSAGNVYVADTGNNRIQKFTSTGTFLTKWgSEGSGdgqfnAPYGIAVDSAGNVYVADTGNN 225


                 ..
gi 667667686 112 SI 113
Cdd:cd14955  226 RI 227
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 51-111 3.39e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 35.65  E-value: 3.39e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 667667686  51 PAGICSNSEGNVIVADEQRRQV-TLFPRAGPPICLVSEGLGQPLGVACAPQGQLLVADAKDN 111
Cdd:cd14952   96 PTGVAVDAAGNVYVADTGNNRVlKLAAGSNTQTVLPFTGLSNPDGVAVDGAGNVYVTDTGNN 157
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 10-116 3.59e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 35.72  E-value: 3.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667686  10 VGPGPDGGLAVSEEFGD-VRLFGSARQPLGSLG--GWTGHTFGCPAGICSNSEGNVIVADEQRRQVTLFPRAGppICLVS 86
Cdd:cd14956  159 VAVDPDGTLYVADTYNDrIQVFDNDGAFLRKWGgrGTGPGQFNYPYGIAIDPDGNVFVADFGNNRIQKFTADG--TFLTS 236

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 667667686  87 EG--------LGQPLGVACAPQGQLLVADAKDNSIKVY 116
Cdd:cd14956  237 WGspgtgpgqFKNPWGVVVDADGTVYVADSNNNRVQRF 274
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
 92-116 4.18e-03

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 35.63  E-value: 4.18e-03
                         10        20
                 ....*....|....*....|....*
gi 667667686  92 PLGVACAPQGQLLVADAKDNSIKVY 116
Cdd:cd14951  198 PLGVAALPDGSVYVADTYNHKIKRV 222
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 48-113 4.53e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 35.24  E-value: 4.53e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 667667686  48 FGCPAGICSNSEGNVIVADEQRRQVTLFPRAGPPICLV-SEGLG-----QPLGVACAPQGQLLVADAKDNSI 113
Cdd:cd14955   15 FNSPSGIAVDSAGNVYVADTGNNRIQKFDSTGTFLTKWgSSGSGdgqfySPTGIAVDSDGNVYVADTGNHRI 86
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 31-108 6.10e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 34.95  E-value: 6.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667686  31 GSARQPLGSLGGWTGHtFGCPAGICSNSEGNVIVADEQRRQVTLFPRAGPPICLVS---EGLGQ---PLGVACAPQGQLL 104
Cdd:cd14956   43 GTFLRRFGTTGDGPGQ-FGRPRGLAVDKDGWLYVADYWGDRIQVFTLTGELQTIGGssgSGPGQfnaPRGVAVDADGNLY 121


                 ....
gi 667667686 105 VADA 108
Cdd:cd14956  122 VADF 125
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
6-113 6.36e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 35.00  E-value: 6.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667686   6 GPCWVGPGPDGGLAVSEEFGD-VRLFGSARqplGSLGGWTGHTFGCPAGICSNSEGNVIVADEQRRQVTLF-PRAGPPIC 83
Cdd:COG4257   18 GPRDVAVDPDGAVWFTDQGGGrIGRLDPAT---GEFTEYPLGGGSGPHGIAVDPDGNLWFTDNGNNRIGRIdPKTGEITT 94

                         90       100       110
                 ....*....|....*....|....*....|.
gi 667667686  84 LVSEGLG-QPLGVACAPQGQLLVADAKDNSI 113
Cdd:COG4257   95 FALPGGGsNPHGIAFDPDGNLWFTDQGGNRI 125
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
 30-117 6.75e-03

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 34.63  E-value: 6.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667686  30 FGSARQPLGSLGGWTGHTFgcpagicsNSEGNVIVADEQRRQVTLFPRAGPPICLVSEG-LGQPLGVACAPQGQLLVADA 108
Cdd:cd14960   53 FGVRGRSPGQLQRPTGVAV--------TLNGDIIIADYDNKWVSIFSPDGKFKSKIGAGkLMGPKGVAVDRNGHIIVVDN 124


                 ....*....
gi 667667686 109 KDNSIKVYQ 117
Cdd:cd14960  125 KACCVFIFQ 133
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 51-111 8.14e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 34.49  E-value: 8.14e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 667667686  51 PAGICSNSEGNVIVADEQRRQVT-LFPRAGPPICLVSEGLGQPLGVACAPQGQLLVADAKDN 111
Cdd:cd14952  180 PSGVAVDTAGNVYVTDHGNNRVLkLAAGSTTPTVLPFTGLNGPLGVAVDAAGNVYVADRGND 241
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 13-116 9.73e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 34.49  E-value: 9.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667686  13 GPDGGLAVSE-EFGDVRLFGSARQPLGSLGGwtGHTFGCPAGICSNSEGNVI-VADEQRRQVTLFPRAGPpicLVS---- 86
Cdd:cd14962   65 DANGNLYVSDaELGKVFVFDRDGKFLRAIGA--GALFKRPTGIAVDPAGKRLyVVDTLAHKVKVFDLDGR---LLFdigk 139

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 667667686  87 --EGLGQ---PLGVACAPQGQLLVADAKDNSIKVY 116
Cdd:cd14962  140 rgSGPGEfnlPTDLAVDRDGNLYVTDTMNFRVQIF 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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