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Conserved domains on  [gi|665821245|ref|NP_001287899|]
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zinc finger protein 566 isoform 3 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
149-300 2.56e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 2.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821245 149 KPYECKECGKAFSSGSNFTRHQR--IHTGE--KPYECKE--CGKAFSSGSNFTQHQRIHTGEKPYECK--ECGNAFSQSS 220
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821245 221 -----QLIKHQRIHTGEKPYEC--KECEKAFRSGSDLTRHQRIHTGEKPYECK--ICGKAYSQSSQLISHHRIHTSEKPY 291
Cdd:COG5048  368 nneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447


                 ....*....
gi 665821245 292 EYRECGKNF 300
Cdd:COG5048  448 LCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
49-209 2.97e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 2.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821245  49 SHHPSFTLQQIINSKKKFCASKEYRKTFRHGSQFATH--EIIHTIE--KPYECKE--CGKSFRHPSRLTHHQKIHTGKKP 122
Cdd:COG5048  272 SSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821245 123 FECKEC-------GKTFICGSDLTRHHRIHTGEKPYEC--KECGKAFSSGSNFTRHQRIHTGEKPYECK--ECGKAFSSG 191
Cdd:COG5048  352 AKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                        170
                 ....*....|....*...
gi 665821245 192 SNFTQHQRIHTGEKPYEC 209
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLC 449
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
149-300 2.56e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 2.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821245 149 KPYECKECGKAFSSGSNFTRHQR--IHTGE--KPYECKE--CGKAFSSGSNFTQHQRIHTGEKPYECK--ECGNAFSQSS 220
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821245 221 -----QLIKHQRIHTGEKPYEC--KECEKAFRSGSDLTRHQRIHTGEKPYECK--ICGKAYSQSSQLISHHRIHTSEKPY 291
Cdd:COG5048  368 nneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447


                 ....*....
gi 665821245 292 EYRECGKNF 300
Cdd:COG5048  448 LCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
49-209 2.97e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 2.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821245  49 SHHPSFTLQQIINSKKKFCASKEYRKTFRHGSQFATH--EIIHTIE--KPYECKE--CGKSFRHPSRLTHHQKIHTGKKP 122
Cdd:COG5048  272 SSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821245 123 FECKEC-------GKTFICGSDLTRHHRIHTGEKPYEC--KECGKAFSSGSNFTRHQRIHTGEKPYECK--ECGKAFSSG 191
Cdd:COG5048  352 AKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                        170
                 ....*....|....*...
gi 665821245 192 SNFTQHQRIHTGEKPYEC 209
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
165-190 3.10e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 3.10e-04
                          10        20
                  ....*....|....*....|....*.
gi 665821245  165 NFTRHQRIHTGEKPYECKECGKAFSS 190
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
149-300 2.56e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 2.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821245 149 KPYECKECGKAFSSGSNFTRHQR--IHTGE--KPYECKE--CGKAFSSGSNFTQHQRIHTGEKPYECK--ECGNAFSQSS 220
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821245 221 -----QLIKHQRIHTGEKPYEC--KECEKAFRSGSDLTRHQRIHTGEKPYECK--ICGKAYSQSSQLISHHRIHTSEKPY 291
Cdd:COG5048  368 nneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447


                 ....*....
gi 665821245 292 EYRECGKNF 300
Cdd:COG5048  448 LCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
93-253 1.23e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 1.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821245  93 KPYECKECGKSFRHPSRLTHHQ--KIHTGK--KPFECKE--CGKTFICGSDLTRHHRIHTGEKPYECK--ECGKAFSSGS 164
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821245 165 N-----FTRHQRIHTGEKPYEC--KECGKAFSSGSNFTQHQRIHTGEKPYECK--ECGNAFSQSSQLIKHQRIHTGEKPY 235
Cdd:COG5048  368 NneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....*...
gi 665821245 236 ECkECEKAFRSGSDLTRH 253
Cdd:COG5048  448 LC-SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
205-309 1.71e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 1.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821245 205 KPYECKECGNAFSQSSQLIKHQRIHTGEKPYEC--KECEKAFRSGSDLTRHQRIHTGEKPYECKICGKAYSQSSqlishh 282
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKA------ 105

                         90       100
                 ....*....|....*....|....*..
gi 665821245 283 rihtseKPYEYRECGKNFNYDPQLIQH 309
Cdd:COG5048  106 ------SSSSLSSSSSNSNDNNLLSSH 126
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
49-209 2.97e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 2.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821245  49 SHHPSFTLQQIINSKKKFCASKEYRKTFRHGSQFATH--EIIHTIE--KPYECKE--CGKSFRHPSRLTHHQKIHTGKKP 122
Cdd:COG5048  272 SSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821245 123 FECKEC-------GKTFICGSDLTRHHRIHTGEKPYEC--KECGKAFSSGSNFTRHQRIHTGEKPYECK--ECGKAFSSG 191
Cdd:COG5048  352 AKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                        170
                 ....*....|....*...
gi 665821245 192 SNFTQHQRIHTGEKPYEC 209
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
165-190 3.10e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 3.10e-04
                          10        20
                  ....*....|....*....|....*.
gi 665821245  165 NFTRHQRIHTGEKPYECKECGKAFSS 190
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
137-162 4.87e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 4.87e-04
                          10        20
                  ....*....|....*....|....*.
gi 665821245  137 DLTRHHRIHTGEKPYECKECGKAFSS 162
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
249-274 1.15e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.15e-03
                          10        20
                  ....*....|....*....|....*.
gi 665821245  249 DLTRHQRIHTGEKPYECKICGKAYSQ 274
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
177-312 1.47e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 1.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821245 177 KPYECKECGKAFSSGSNFTQHQR--IHTGE--KPYECKE--CGNAFSQSSQLIKHQRIHTGEKPYECK--ECEKAFRSGS 248
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665821245 249 D-----LTRHQRIHTGEKPYEC--KICGKAYSQSSQLISHHRIHTSEKPYEYR--ECGKNFNYDPQLIQHQNL 312
Cdd:COG5048  368 NneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKI 440
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
149-209 1.55e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 1.55e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665821245 149 KPYECKECGKAFSSGSNFTRHQRIHTGEKPYEC--KECGKAFSSGSNFTQHQRIHTGEKPYEC 209
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN 94
zf-H2C2_2 pfam13465
Zinc-finger double domain;
222-246 2.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.02e-03
                          10        20
                  ....*....|....*....|....*
gi 665821245  222 LIKHQRIHTGEKPYECKECEKAFRS 246
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
193-218 2.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.14e-03
                          10        20
                  ....*....|....*....|....*.
gi 665821245  193 NFTQHQRIHTGEKPYECKECGNAFSQ 218
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 203-286 3.99e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.55  E-value: 3.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821245 203 GEKPYECK--ECGNAFSQSSQLiKHQRIHtgekpyecKECEKAFRSGSDLTRHQRIHTGEKPYECKICGKAYSQSSQLiS 280
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGL-KYHMLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGL-K 415


                 ....*.
gi 665821245 281 HHRIHT 286
Cdd:COG5189  416 YHRKHS 421
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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