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Conserved domains on  [gi|595763308|ref|NP_001277714|]
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protein transport protein Sec24A isoform 2 [Mus musculus]

Protein Classification

SEC24 family transport protein( domain architecture ID 1001573)

SEC24 family transport protein is a component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5028 super family cl34873
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
 295-1089 3.62e-179

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5028:

Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 545.93  E-value: 3.62e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  295 PGYQnSAPPVAGMPPPSLSYPSgpQAFTQTPLGANHLTASMSglslhpeglrvvnllqernmlpstPLQPPVPNLLEDIQ 374
Cdd:COG5028    92 PYGG-SMADGTAPKPTNPLVPV--DLFEDQPPPISDLFLPPP------------------------PIVPPLTTNFVGSE 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  375 KLNCNPELFRCTLTSVPQTQALLNKAKLPLGLLLHPFKDLV-----LPVVTSSTIVRCRSCRTYINPFVNFLDQ-RRWKC 448
Cdd:COG5028   145 QSNCSPKYVRSTMYAIPETNDLLKKSKIPFGLVIRPFLELYpeedpVPLVEDGSIVRCRRCRSYINPFVQFIEQgRKWRC 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  449 NLCYRVNDVPEEFmYNPLTRV--YGEPHKRPEVQNATIEFMAPSEYMLRPPQPPVYLFVFDVSHNAIETGYLNSVCQSLL 526
Cdd:COG5028   225 NICRSKNDVPEGF-DNPSGPNdpRSDRYSRPELKSGVVDFLAPKEYSLRQPPPPVYVFLIDVSFEAIKNGLVKAAIRAIL 303

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  527 DNLDLLPG-NTRTKIGFITFDSTIHFYSLQEGLSQpQMLIVSDIDDVFIPMPENLLV-NLNESKELVQDLLKTLPQMFTK 604
Cdd:COG5028   304 ENLDQIPNfDPRTKIAIICFDSSLHFFKLSPDLDE-QMLIVSDLDEPFLPFPSGLFVlPLKSCKQIIETLLDRVPRIFQD 382

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  605 TLETQSALGPALQAAFKLISPTGGRMSVFQTQLPTLGVGALKPREEPNQRssakeiHLTPSTDFYKKLALDCSGQQAAVD 684
Cdd:COG5028   383 NKSPKNALGPALKAAKSLIGGTGGKIIVFLSTLPNMGIGKLQLREDKESS------LLSCKDSFYKEFAIECSKVGISVD 456

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  685 LFLLSGQYSDLASLGCISRYSAGSVYYYPSYHhQHNPVQVQKLQKELHRYLTRKIGFEAVMRIRCTKGLSIHTFHGNFFV 764
Cdd:COG5028   457 LFLTSEDYIDVATLSHLCRYTGGQTYFYPNFS-ATRPNDATKLANDLVSHLSMEIGYEAVMRVRCSTGLRVSSFYGNFFN 535

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  765 RSTDLLSLPNVNPDAGYAVQMSVEESLTdTQLVSFQSALLYTSSKGERRIRVHTLCLPVVSTLNEVFLGADVQAISGLLA 844
Cdd:COG5028   536 RSSDLCAFSTMPRDTSLLVEFSIDEKLM-TSDVYFQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASADQLAIACILA 614

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  845 NMAVDRSVTASLSDARDALVNAVIDSLSAYRSSVLSGQQPGLMV-PFSLRLFPLFVLALLKQKSFQTGtSIRLDERIFAM 923
Cdd:COG5028   615 KKASTKALNSSLKEARVLINKSMVDILKAYKKELVKSNTSTQLPlPANLKLLPLLMLALLKSSAFRSG-STPSDIRISAL 693

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  924 CQVKSQPLVHLMLTTHPSLYRVDNLSDEGALNINDRTI-PQPpiLQLSVEKLSRDGAFLMDAGSLLMLWVGRNCSQNFLS 1002
Cdd:COG5028   694 NRLTSLPLKQLMRNIYPTLYALHDMPIEAGLPDEGLLVlPSP--INATSSLLESGGLYLIDTGQKIFLWFGKDAVPSLLQ 771

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308 1003 QVLGVQNYASIPQTMTDLPELDTPESARIAAFISWLREQRPFF-PVLYVIRE--ESLMKAAFLQSLVEDRTESALSYYEF 1079
Cdd:COG5028   772 DLFGVDSLSDIPSGKFTLPPTGNEFNERVRNIIGELRSVNDDStLPLVLVRGggDPSLRLWFFSTLVEDKTLNIPSYLDY 851

                         810
                  ....*....|
gi 595763308 1080 LLHIQQQVNK 1089
Cdd:COG5028   852 LQILHEKIKS 861
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 5-367 8.05e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 8.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308    5 RIPAARGAAASLQAQNGAASASGSPYTNGPVHNTLMSPQVSSSQGYDSQPPGsyPRPMPAKTlnpfsaqsnyggsqgsgq 84
Cdd:PHA03247 2654 DDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPP--PTPEPAPH------------------ 2713

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308   85 tlnsPLVTSGPVLPSLHSGPVPRMPLPTSqnPAATPMPSGSFLPGANPPPPlnwqynypsTGPQTNHFPHVAPPTLP-GN 163
Cdd:PHA03247 2714 ----ALVSATPLPPGPAAARQASPALPAA--PAPPAVPAGPATPGGPARPA---------RPPTTAGPPAPAPPAAPaAG 2778

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  164 PNLTADHQYVSSGDPALQTSFKKPGSALPLQNPPLPPTFQPGAPPGPPPAGGPPPSRGPAPQKTPPRAAPPPSFNSAVNQ 243
Cdd:PHA03247 2779 PPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAP 2858

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  244 EG-ITSNANNGSTAAHNTYDEIEGGGFLATPQLVNQ-NPKTSRSVGSAYPSLPPGYQNSAPPVAGMPPPSLSYPSGPQAF 321
Cdd:PHA03247 2859 GGdVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRStESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR 2938

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 595763308  322 TQTPLGANHLTASMSGLSLHPEGLRVVNLLQERNMLPSTPLQPPVP 367
Cdd:PHA03247 2939 PQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAP 2984
 
Name Accession Description Interval E-value
COG5028 COG5028
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
 295-1089 3.62e-179

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 545.93  E-value: 3.62e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  295 PGYQnSAPPVAGMPPPSLSYPSgpQAFTQTPLGANHLTASMSglslhpeglrvvnllqernmlpstPLQPPVPNLLEDIQ 374
Cdd:COG5028    92 PYGG-SMADGTAPKPTNPLVPV--DLFEDQPPPISDLFLPPP------------------------PIVPPLTTNFVGSE 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  375 KLNCNPELFRCTLTSVPQTQALLNKAKLPLGLLLHPFKDLV-----LPVVTSSTIVRCRSCRTYINPFVNFLDQ-RRWKC 448
Cdd:COG5028   145 QSNCSPKYVRSTMYAIPETNDLLKKSKIPFGLVIRPFLELYpeedpVPLVEDGSIVRCRRCRSYINPFVQFIEQgRKWRC 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  449 NLCYRVNDVPEEFmYNPLTRV--YGEPHKRPEVQNATIEFMAPSEYMLRPPQPPVYLFVFDVSHNAIETGYLNSVCQSLL 526
Cdd:COG5028   225 NICRSKNDVPEGF-DNPSGPNdpRSDRYSRPELKSGVVDFLAPKEYSLRQPPPPVYVFLIDVSFEAIKNGLVKAAIRAIL 303

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  527 DNLDLLPG-NTRTKIGFITFDSTIHFYSLQEGLSQpQMLIVSDIDDVFIPMPENLLV-NLNESKELVQDLLKTLPQMFTK 604
Cdd:COG5028   304 ENLDQIPNfDPRTKIAIICFDSSLHFFKLSPDLDE-QMLIVSDLDEPFLPFPSGLFVlPLKSCKQIIETLLDRVPRIFQD 382

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  605 TLETQSALGPALQAAFKLISPTGGRMSVFQTQLPTLGVGALKPREEPNQRssakeiHLTPSTDFYKKLALDCSGQQAAVD 684
Cdd:COG5028   383 NKSPKNALGPALKAAKSLIGGTGGKIIVFLSTLPNMGIGKLQLREDKESS------LLSCKDSFYKEFAIECSKVGISVD 456

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  685 LFLLSGQYSDLASLGCISRYSAGSVYYYPSYHhQHNPVQVQKLQKELHRYLTRKIGFEAVMRIRCTKGLSIHTFHGNFFV 764
Cdd:COG5028   457 LFLTSEDYIDVATLSHLCRYTGGQTYFYPNFS-ATRPNDATKLANDLVSHLSMEIGYEAVMRVRCSTGLRVSSFYGNFFN 535

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  765 RSTDLLSLPNVNPDAGYAVQMSVEESLTdTQLVSFQSALLYTSSKGERRIRVHTLCLPVVSTLNEVFLGADVQAISGLLA 844
Cdd:COG5028   536 RSSDLCAFSTMPRDTSLLVEFSIDEKLM-TSDVYFQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASADQLAIACILA 614

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  845 NMAVDRSVTASLSDARDALVNAVIDSLSAYRSSVLSGQQPGLMV-PFSLRLFPLFVLALLKQKSFQTGtSIRLDERIFAM 923
Cdd:COG5028   615 KKASTKALNSSLKEARVLINKSMVDILKAYKKELVKSNTSTQLPlPANLKLLPLLMLALLKSSAFRSG-STPSDIRISAL 693

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  924 CQVKSQPLVHLMLTTHPSLYRVDNLSDEGALNINDRTI-PQPpiLQLSVEKLSRDGAFLMDAGSLLMLWVGRNCSQNFLS 1002
Cdd:COG5028   694 NRLTSLPLKQLMRNIYPTLYALHDMPIEAGLPDEGLLVlPSP--INATSSLLESGGLYLIDTGQKIFLWFGKDAVPSLLQ 771

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308 1003 QVLGVQNYASIPQTMTDLPELDTPESARIAAFISWLREQRPFF-PVLYVIRE--ESLMKAAFLQSLVEDRTESALSYYEF 1079
Cdd:COG5028   772 DLFGVDSLSDIPSGKFTLPPTGNEFNERVRNIIGELRSVNDDStLPLVLVRGggDPSLRLWFFSTLVEDKTLNIPSYLDY 851

                         810
                  ....*....|
gi 595763308 1080 LLHIQQQVNK 1089
Cdd:COG5028   852 LQILHEKIKS 861
Sec24-like cd01479
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ...
 497-739 2.13e-128

Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.


Pssm-ID: 238756 [Multi-domain]  Cd Length: 244  Bit Score: 390.48  E-value: 2.13e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  497 PQPPVYLFVFDVSHNAIETGYLNSVCQSLLDNLDLLPGN-TRTKIGFITFDSTIHFYSLQEGLSQPQMLIVSDIDDVFIP 575
Cdd:cd01479     1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGDdPRTRVGFITFDSTLHFFNLKSSLEQPQMMVVSDLDDPFLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  576 MPENLLVNLNESKELVQDLLKTLPQMFTKTLETQSALGPALQAAFKLISPTGGRMSVFQTQLPTLGVGALKPREEPNQRS 655
Cdd:cd01479    81 LPDGLLVNLKESRQVIEDLLDQIPEMFQDTKETESALGPALQAAFLLLKETGGKIIVFQSSLPTLGAGKLKSREDPKLLS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  656 SAKE-IHLTPSTDFYKKLALDCSGQQAAVDLFLLSGQYSDLASLGCISRYSAGSVYYYPSyHHQHNPVQVQKLQKELHRY 734
Cdd:cd01479   161 TDKEkQLLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYYPS-FNFSAPNDVEKLVNELARY 239


                  ....*
gi 595763308  735 LTRKI 739
Cdd:cd01479   240 LTRKI 244
Sec23_trunk pfam04811
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ...
 497-735 1.17e-104

Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.


Pssm-ID: 398467 [Multi-domain]  Cd Length: 241  Bit Score: 327.67  E-value: 1.17e-104
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308   497 PQPPVYLFVFDVSHNAIETGYLNSVCQSLLDNLDLLPGNTRTKIGFITFDSTIHFYSLQEGLSQPQMLIVSDIDDVFIPM 576
Cdd:pfam04811    1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGDPRARVGFITFDSTVHFFNLGSSLRQPQMLVVSDLQDMFLPL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308   577 PENLLVNLNESKELVQDLLKTLPQMFTKTLETQSALGPALQAAFKLI--SPTGGRMSVFQTQLPTLGV-GALKPREEPNQ 653
Cdd:pfam04811   81 PDRFLVPLSECRFVLEDLLEQLPPMFPVTKRPERCLGPALQAAFLLLkaAFTGGKIMVFQGGLPTVGPgGKLKSRLDESH 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308   654 RSSAKE-IHLTPSTD-FYKKLALDCSGQQAAVDLFLLSGQYSDLASLGCISRYSAGSVYYYPSYHHQHnpvQVQKLQKEL 731
Cdd:pfam04811  161 HGTDKEkAKLVKKADkFYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADV---DGSKFKQDL 237


                   ....
gi 595763308   732 HRYL 735
Cdd:pfam04811  238 QRYF 241
PTZ00395 PTZ00395
Sec24-related protein; Provisional
 462-1089 3.71e-49

Sec24-related protein; Provisional


Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 191.06  E-value: 3.71e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  462 MYNPLTRVYGEPHKRPEVQNATIEFMAPSEYMLrppqPPVYLFVFDVSHNAIetgyLNSVCQSLLDNLDLLPGNTR---T 538
Cdd:PTZ00395  919 MKNLICEKNGEPDSAKIRRNSFLAKYPQVKNML----PPYFVFVVECSYNAI----YNNITYTILEGIRYAVQNVKcpqT 990

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  539 KIGFITFDSTIHFYSLQEGLSQP-------------QMLIVSDIDDVFIPMP-ENLLVNLNESKELVQDLLKTLPQMFTK 604
Cdd:PTZ00395  991 KIAIITFNSSIYFYHCKGGKGVSgeegdggggsgnhQVIVMSDVDDPFLPLPlEDLFFGCVEEIDKINTLIDTIKSVSTT 1070

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  605 TLETQSALGPALQAAFKLISPTGGRMSV--FQTQLPTLGVGALKPREEPNQRSSAKeihlTPSTDFYKKLALDCSGQQAA 682
Cdd:PTZ00395 1071 MQSYGSCGNSALKIAMDMLKERNGLGSIcmFYTTTPNCGIGAIKELKKDLQENFLE----VKQKIFYDSLLLDLYAFNIS 1146

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  683 VDLFLLSGQYSDLA--SLGCISRYSAGSVYYYPSYHHQHNpvqVQKLQKELHRYLTRK-IGFEAVMRIRCTKGLSIHTF- 758
Cdd:PTZ00395 1147 VDIFIISSNNVRVCvpSLQYVAQNTGGKILFVENFLWQKD---YKEIYMNIMDTLTSEdIAYCCELKLRYSHHMSVKKLf 1223

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  759 --HGNF-FVRSTDLLSLPNVNPDAGYAVQMSVEESLTDTQLVSFQSALLYTSSKGERRIRVHTLCLPVVSTLNEVFLGAD 835
Cdd:PTZ00395 1224 ccNNNFnSIISVDTIKIPKIRHDQTFAFLLNYSDISESKKQIYFQCACIYTNLWGDRFVRLHTTHMNLTSSLSTVFRYTD 1303

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  836 VQAisglLANMAVDRSVTASLSDarDALVNAVIDSLSA----YR----SSVLSGQqpgLMVPFSLRLFPLFVLALLKQKS 907
Cdd:PTZ00395 1304 AEA----LMNILIKQLCTNILHN--DNYSKIIIDNLAAilfsYRincaSSAHSGQ---LILPDTLKLLPLFTSSLLKHNV 1374

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  908 fqTGTSIRLDERIFAMCQVKSQPLVHLMLTTHPSLY--RVDNLSDE-GALNIND-----RTIPQppilqlSVEKLSRDGA 979
Cdd:PTZ00395 1375 --TKKEILHDLKVYSLIKLLSMPIISSLLYVYPVMYviHIKGKTNEiDSMDVDDdlfipKTIPS------SAEKIYSNGI 1446

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  980 FLMDAGSLLMLWVGRNCSQNFLSQVLGvqnyaSIP--QTMTDLPELDTPESARIAAFISWLREQRPF--FPVLYVIREES 1055
Cdd:PTZ00395 1447 YLLDACTHFYLYFGFHSDANFAKEIVG-----DIPteKNAHELNLTDTPNAQKVQRIIKNLSRIHHFnkYVPLVMVAPKS 1521

                         650       660       670
                  ....*....|....*....|....*....|....
gi 595763308 1056 LMKAAFLQSLVEDRTESALSYYEFLLHIQQQVNK 1089
Cdd:PTZ00395 1522 NEEEHLISLCVEDKADKEYSYVNFLCFIHKLVHK 1555
PHA03247 PHA03247
large tegument protein UL36; Provisional
 5-367 8.05e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 8.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308    5 RIPAARGAAASLQAQNGAASASGSPYTNGPVHNTLMSPQVSSSQGYDSQPPGsyPRPMPAKTlnpfsaqsnyggsqgsgq 84
Cdd:PHA03247 2654 DDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPP--PTPEPAPH------------------ 2713

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308   85 tlnsPLVTSGPVLPSLHSGPVPRMPLPTSqnPAATPMPSGSFLPGANPPPPlnwqynypsTGPQTNHFPHVAPPTLP-GN 163
Cdd:PHA03247 2714 ----ALVSATPLPPGPAAARQASPALPAA--PAPPAVPAGPATPGGPARPA---------RPPTTAGPPAPAPPAAPaAG 2778

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  164 PNLTADHQYVSSGDPALQTSFKKPGSALPLQNPPLPPTFQPGAPPGPPPAGGPPPSRGPAPQKTPPRAAPPPSFNSAVNQ 243
Cdd:PHA03247 2779 PPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAP 2858

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  244 EG-ITSNANNGSTAAHNTYDEIEGGGFLATPQLVNQ-NPKTSRSVGSAYPSLPPGYQNSAPPVAGMPPPSLSYPSGPQAF 321
Cdd:PHA03247 2859 GGdVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRStESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR 2938

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 595763308  322 TQTPLGANHLTASMSGLSLHPEGLRVVNLLQERNMLPSTPLQPPVP 367
Cdd:PHA03247 2939 PQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAP 2984
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 16-180 1.50e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.91  E-value: 1.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308    16 LQAQNGAASASGSPYTNGPVHNTLMSPQVSSSQGYDSQPPGSYPRPMPAKTLNPFSAQSnyggsqgSGQTLNSPLvtsgp 95
Cdd:pfam03154  174 LQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQ-------QTPTLHPQR----- 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308    96 vLPSLHSG--PVPRMPLPTSQNPAATPMPSgsfLPGANPPPPLNWQynypsTGPqtNHFPHVAPPTLPGNPNLTADHQYV 173
Cdd:pfam03154  242 -LPSPHPPlqPMTQPPPPSQVSPQPLPQPS---LHGQMPPMPHSLQ-----TGP--SHMQHPVPPQPFPLTPQSSQSQVP 310


                   ....*..
gi 595763308   174 SSGDPAL 180
Cdd:pfam03154  311 PGPSPAA 317
 
Name Accession Description Interval E-value
COG5028 COG5028
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
 295-1089 3.62e-179

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 545.93  E-value: 3.62e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  295 PGYQnSAPPVAGMPPPSLSYPSgpQAFTQTPLGANHLTASMSglslhpeglrvvnllqernmlpstPLQPPVPNLLEDIQ 374
Cdd:COG5028    92 PYGG-SMADGTAPKPTNPLVPV--DLFEDQPPPISDLFLPPP------------------------PIVPPLTTNFVGSE 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  375 KLNCNPELFRCTLTSVPQTQALLNKAKLPLGLLLHPFKDLV-----LPVVTSSTIVRCRSCRTYINPFVNFLDQ-RRWKC 448
Cdd:COG5028   145 QSNCSPKYVRSTMYAIPETNDLLKKSKIPFGLVIRPFLELYpeedpVPLVEDGSIVRCRRCRSYINPFVQFIEQgRKWRC 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  449 NLCYRVNDVPEEFmYNPLTRV--YGEPHKRPEVQNATIEFMAPSEYMLRPPQPPVYLFVFDVSHNAIETGYLNSVCQSLL 526
Cdd:COG5028   225 NICRSKNDVPEGF-DNPSGPNdpRSDRYSRPELKSGVVDFLAPKEYSLRQPPPPVYVFLIDVSFEAIKNGLVKAAIRAIL 303

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  527 DNLDLLPG-NTRTKIGFITFDSTIHFYSLQEGLSQpQMLIVSDIDDVFIPMPENLLV-NLNESKELVQDLLKTLPQMFTK 604
Cdd:COG5028   304 ENLDQIPNfDPRTKIAIICFDSSLHFFKLSPDLDE-QMLIVSDLDEPFLPFPSGLFVlPLKSCKQIIETLLDRVPRIFQD 382

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  605 TLETQSALGPALQAAFKLISPTGGRMSVFQTQLPTLGVGALKPREEPNQRssakeiHLTPSTDFYKKLALDCSGQQAAVD 684
Cdd:COG5028   383 NKSPKNALGPALKAAKSLIGGTGGKIIVFLSTLPNMGIGKLQLREDKESS------LLSCKDSFYKEFAIECSKVGISVD 456

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  685 LFLLSGQYSDLASLGCISRYSAGSVYYYPSYHhQHNPVQVQKLQKELHRYLTRKIGFEAVMRIRCTKGLSIHTFHGNFFV 764
Cdd:COG5028   457 LFLTSEDYIDVATLSHLCRYTGGQTYFYPNFS-ATRPNDATKLANDLVSHLSMEIGYEAVMRVRCSTGLRVSSFYGNFFN 535

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  765 RSTDLLSLPNVNPDAGYAVQMSVEESLTdTQLVSFQSALLYTSSKGERRIRVHTLCLPVVSTLNEVFLGADVQAISGLLA 844
Cdd:COG5028   536 RSSDLCAFSTMPRDTSLLVEFSIDEKLM-TSDVYFQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASADQLAIACILA 614

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  845 NMAVDRSVTASLSDARDALVNAVIDSLSAYRSSVLSGQQPGLMV-PFSLRLFPLFVLALLKQKSFQTGtSIRLDERIFAM 923
Cdd:COG5028   615 KKASTKALNSSLKEARVLINKSMVDILKAYKKELVKSNTSTQLPlPANLKLLPLLMLALLKSSAFRSG-STPSDIRISAL 693

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  924 CQVKSQPLVHLMLTTHPSLYRVDNLSDEGALNINDRTI-PQPpiLQLSVEKLSRDGAFLMDAGSLLMLWVGRNCSQNFLS 1002
Cdd:COG5028   694 NRLTSLPLKQLMRNIYPTLYALHDMPIEAGLPDEGLLVlPSP--INATSSLLESGGLYLIDTGQKIFLWFGKDAVPSLLQ 771

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308 1003 QVLGVQNYASIPQTMTDLPELDTPESARIAAFISWLREQRPFF-PVLYVIRE--ESLMKAAFLQSLVEDRTESALSYYEF 1079
Cdd:COG5028   772 DLFGVDSLSDIPSGKFTLPPTGNEFNERVRNIIGELRSVNDDStLPLVLVRGggDPSLRLWFFSTLVEDKTLNIPSYLDY 851

                         810
                  ....*....|
gi 595763308 1080 LLHIQQQVNK 1089
Cdd:COG5028   852 LQILHEKIKS 861
Sec24-like cd01479
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ...
 497-739 2.13e-128

Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.


Pssm-ID: 238756 [Multi-domain]  Cd Length: 244  Bit Score: 390.48  E-value: 2.13e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  497 PQPPVYLFVFDVSHNAIETGYLNSVCQSLLDNLDLLPGN-TRTKIGFITFDSTIHFYSLQEGLSQPQMLIVSDIDDVFIP 575
Cdd:cd01479     1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGDdPRTRVGFITFDSTLHFFNLKSSLEQPQMMVVSDLDDPFLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  576 MPENLLVNLNESKELVQDLLKTLPQMFTKTLETQSALGPALQAAFKLISPTGGRMSVFQTQLPTLGVGALKPREEPNQRS 655
Cdd:cd01479    81 LPDGLLVNLKESRQVIEDLLDQIPEMFQDTKETESALGPALQAAFLLLKETGGKIIVFQSSLPTLGAGKLKSREDPKLLS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  656 SAKE-IHLTPSTDFYKKLALDCSGQQAAVDLFLLSGQYSDLASLGCISRYSAGSVYYYPSyHHQHNPVQVQKLQKELHRY 734
Cdd:cd01479   161 TDKEkQLLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYYPS-FNFSAPNDVEKLVNELARY 239


                  ....*
gi 595763308  735 LTRKI 739
Cdd:cd01479   240 LTRKI 244
Sec23_trunk pfam04811
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ...
 497-735 1.17e-104

Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.


Pssm-ID: 398467 [Multi-domain]  Cd Length: 241  Bit Score: 327.67  E-value: 1.17e-104
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308   497 PQPPVYLFVFDVSHNAIETGYLNSVCQSLLDNLDLLPGNTRTKIGFITFDSTIHFYSLQEGLSQPQMLIVSDIDDVFIPM 576
Cdd:pfam04811    1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGDPRARVGFITFDSTVHFFNLGSSLRQPQMLVVSDLQDMFLPL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308   577 PENLLVNLNESKELVQDLLKTLPQMFTKTLETQSALGPALQAAFKLI--SPTGGRMSVFQTQLPTLGV-GALKPREEPNQ 653
Cdd:pfam04811   81 PDRFLVPLSECRFVLEDLLEQLPPMFPVTKRPERCLGPALQAAFLLLkaAFTGGKIMVFQGGLPTVGPgGKLKSRLDESH 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308   654 RSSAKE-IHLTPSTD-FYKKLALDCSGQQAAVDLFLLSGQYSDLASLGCISRYSAGSVYYYPSYHHQHnpvQVQKLQKEL 731
Cdd:pfam04811  161 HGTDKEkAKLVKKADkFYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADV---DGSKFKQDL 237


                   ....
gi 595763308   732 HRYL 735
Cdd:pfam04811  238 QRYF 241
trunk_domain cd01468
trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi ...
 497-733 1.11e-100

trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface. Some members of this family possess a partial MIDAS motif that is a characteristic feature of most vWA domain proteins.


Pssm-ID: 238745 [Multi-domain]  Cd Length: 239  Bit Score: 317.26  E-value: 1.11e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  497 PQPPVYLFVFDVSHNAIETGYLNSVCQSLLDNLDLLPGNTRTKIGFITFDSTIHFYSLQEGLSQPQMLIVSDIDDVFIPM 576
Cdd:cd01468     1 PQPPVFVFVIDVSYEAIKEGLLQALKESLLASLDLLPGDPRARVGLITYDSTVHFYNLSSDLAQPKMYVVSDLKDVFLPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  577 PENLLVNLNESKELVQDLLKTLPQMFTK--TLETQSALGPALQAAFKLISPT--GGRMSVFQTQLPTLGVGALKPREEPN 652
Cdd:cd01468    81 PDRFLVPLSECKKVIHDLLEQLPPMFWPvpTHRPERCLGPALQAAFLLLKGTfaGGRIIVFQGGLPTVGPGKLKSREDKE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  653 QRSSAKE-IHLTPSTDFYKKLALDCSGQQAAVDLFLLSGQYSDLASLGCISRYSAGSVYYYPSYHHqhnPVQVQKLQKEL 731
Cdd:cd01468   161 PIRSHDEaQLLKPATKFYKSLAKECVKSGICVDLFAFSLDYVDVATLKQLAKSTGGQVYLYDSFQA---PNDGSKFKQDL 237


                  ..
gi 595763308  732 HR 733
Cdd:cd01468   238 QR 239
PTZ00395 PTZ00395
Sec24-related protein; Provisional
 462-1089 3.71e-49

Sec24-related protein; Provisional


Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 191.06  E-value: 3.71e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  462 MYNPLTRVYGEPHKRPEVQNATIEFMAPSEYMLrppqPPVYLFVFDVSHNAIetgyLNSVCQSLLDNLDLLPGNTR---T 538
Cdd:PTZ00395  919 MKNLICEKNGEPDSAKIRRNSFLAKYPQVKNML----PPYFVFVVECSYNAI----YNNITYTILEGIRYAVQNVKcpqT 990

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  539 KIGFITFDSTIHFYSLQEGLSQP-------------QMLIVSDIDDVFIPMP-ENLLVNLNESKELVQDLLKTLPQMFTK 604
Cdd:PTZ00395  991 KIAIITFNSSIYFYHCKGGKGVSgeegdggggsgnhQVIVMSDVDDPFLPLPlEDLFFGCVEEIDKINTLIDTIKSVSTT 1070

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  605 TLETQSALGPALQAAFKLISPTGGRMSV--FQTQLPTLGVGALKPREEPNQRSSAKeihlTPSTDFYKKLALDCSGQQAA 682
Cdd:PTZ00395 1071 MQSYGSCGNSALKIAMDMLKERNGLGSIcmFYTTTPNCGIGAIKELKKDLQENFLE----VKQKIFYDSLLLDLYAFNIS 1146

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  683 VDLFLLSGQYSDLA--SLGCISRYSAGSVYYYPSYHHQHNpvqVQKLQKELHRYLTRK-IGFEAVMRIRCTKGLSIHTF- 758
Cdd:PTZ00395 1147 VDIFIISSNNVRVCvpSLQYVAQNTGGKILFVENFLWQKD---YKEIYMNIMDTLTSEdIAYCCELKLRYSHHMSVKKLf 1223

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  759 --HGNF-FVRSTDLLSLPNVNPDAGYAVQMSVEESLTDTQLVSFQSALLYTSSKGERRIRVHTLCLPVVSTLNEVFLGAD 835
Cdd:PTZ00395 1224 ccNNNFnSIISVDTIKIPKIRHDQTFAFLLNYSDISESKKQIYFQCACIYTNLWGDRFVRLHTTHMNLTSSLSTVFRYTD 1303

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  836 VQAisglLANMAVDRSVTASLSDarDALVNAVIDSLSA----YR----SSVLSGQqpgLMVPFSLRLFPLFVLALLKQKS 907
Cdd:PTZ00395 1304 AEA----LMNILIKQLCTNILHN--DNYSKIIIDNLAAilfsYRincaSSAHSGQ---LILPDTLKLLPLFTSSLLKHNV 1374

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  908 fqTGTSIRLDERIFAMCQVKSQPLVHLMLTTHPSLY--RVDNLSDE-GALNIND-----RTIPQppilqlSVEKLSRDGA 979
Cdd:PTZ00395 1375 --TKKEILHDLKVYSLIKLLSMPIISSLLYVYPVMYviHIKGKTNEiDSMDVDDdlfipKTIPS------SAEKIYSNGI 1446

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  980 FLMDAGSLLMLWVGRNCSQNFLSQVLGvqnyaSIP--QTMTDLPELDTPESARIAAFISWLREQRPF--FPVLYVIREES 1055
Cdd:PTZ00395 1447 YLLDACTHFYLYFGFHSDANFAKEIVG-----DIPteKNAHELNLTDTPNAQKVQRIIKNLSRIHHFnkYVPLVMVAPKS 1521

                         650       660       670
                  ....*....|....*....|....*....|....
gi 595763308 1056 LMKAAFLQSLVEDRTESALSYYEFLLHIQQQVNK 1089
Cdd:PTZ00395 1522 NEEEHLISLCVEDKADKEYSYVNFLCFIHKLVHK 1555
Sec23_BS pfam08033
Sec23/Sec24 beta-sandwich domain;
740-824 2.30e-32

Sec23/Sec24 beta-sandwich domain;


Pssm-ID: 429794 [Multi-domain]  Cd Length: 86  Bit Score: 120.72  E-value: 2.30e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308   740 GFEAVMRIRCTKGLSIHTFHGNFFVRS-TDLLSLPNVNPDAGYAVQMSVEESLTDTQLVSFQSALLYTSSKGERRIRVHT 818
Cdd:pfam08033    1 GFNAVLRVRTSKGLKVSGFIGNFVSRSsGDTWKLPSLDPDTSYAFEFDIDEPLPNGSNAYIQFALLYTHSSGERRIRVTT 80


                   ....*.
gi 595763308   819 LCLPVV 824
Cdd:pfam08033   81 VALPVT 86
Sec23_helical pfam04815
Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic ...
 835-936 2.57e-32

Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is composed of five alpha helices.


Pssm-ID: 461441 [Multi-domain]  Cd Length: 103  Bit Score: 121.07  E-value: 2.57e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308   835 DVQAISGLLANMAVDRSVTASLSDARDALVNAVIDSLSAYRSSVLSGQQPG-LMVPFSLRLFPLFVLALLKQKSFQTGTS 913
Cdd:pfam04815    1 DQEAIAVLLAKKAVEKALSSSLSDAREALDNKLVDILAAYRKYCASSSSPGqLILPESLKLLPLYMLALLKSPALRGGNS 80

                           90       100
                   ....*....|....*....|...
gi 595763308   914 IRLDERIFAMCQVKSQPLVHLML 936
Cdd:pfam04815   81 SPSDERAYARHLLLSLPVEELLL 103
zf-Sec23_Sec24 pfam04810
Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum ...
 424-460 3.95e-16

Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is found to be zinc binding domain.


Pssm-ID: 461437 [Multi-domain]  Cd Length: 38  Bit Score: 72.86  E-value: 3.95e-16
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 595763308   424 IVRCRSCRTYINPFVNFLDQ-RRWKCNLCYRVNDVPEE 460
Cdd:pfam04810    1 PVRCRRCRAYLNPFCQFDFGgKKWTCNFCGTRNPVPPE 38
SEC23 COG5047
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];
384-858 1.56e-14

Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];


Pssm-ID: 227380 [Multi-domain]  Cd Length: 755  Bit Score: 78.38  E-value: 1.56e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  384 RCTLTSVPQTQALLNKAKLPLGLLLHPFK-DLVLPVVTSSTIVRCRSCRTYINPFVNFLDQRR-WKCNLCYRVNDVPEEF 461
Cdd:COG5047    13 RLTWNVFPATRGDATRTVIPIACLYTPLHeDDALTVNYYEPVKCTAPCKAVLNPYCHIDERNQsWICPFCNQRNTLPPQY 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  462 MYNPLTRVYGEPHKrpevQNATIEFMAPseymlRPPQ-PPVYLFVFDVshnAIETGYLNSVCQSLLDNLDLLPGNTRtkI 540
Cdd:COG5047    93 RDISNANLPLELLP----QSSTIEYTLS-----KPVIlPPVFFFVVDA---CCDEEELTALKDSLIVSLSLLPPEAL--V 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  541 GFITFDSTIHF----------------------YSLQE--GLSQPQMLIV--SDIDDVFIPMPENLLVNLNESKELVQDL 594
Cdd:COG5047   159 GLITYGTSIQVhelnaenhrrsyvfsgnkeytkENLQEllALSKPTKSGGfeSKISGIGQFASSRFLLPTQQCEFKLLNI 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  595 LKTL---PQMFTKTLETQSALGPALQAAFKLIS----PTGGRMSVFQTQLPTLGVGALKPRE--EPnQRS-----SAKEI 660
Cdd:COG5047   239 LEQLqpdPWPVPAGKRPLRCTGSALNIASSLLEqcfpNAGCHIVLFAGGPCTVGPGTVVSTElkEP-MRShhdieSDSAQ 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  661 HLTPSTDFYKKLALDCSGQQAAVDLFLLSGQYSDLASLGCISRYSAGSVYYYPSYHHQHNPVQVQK-LQKELHRYLtrKI 739
Cdd:COG5047   318 HSKKATKFYKGLAERVANQGHALDIFAGCLDQIGIMEMEPLTTSTGGALVLSDSFTTSIFKQSFQRiFNRDSEGYL--KM 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  740 GFEAVMRIRCTKGLSIHTFHGN---------------FFVRSTDLLSLPNVNPDAGYAV------QMSVEESLTDTQ-LV 797
Cdd:COG5047   396 GFNANMEVKTSKNLKIKGLIGHavsvkkkannisdseIGIGATNSWKMASLSPKSNYALyfeialGAASGSAQRPAEaYI 475

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 595763308  798 SFQSalLYTSSKGERRIRVHTLCLPVVSTLNEVFLGA-DVQAISGLLANMAVDRSVTASLSD 858
Cdd:COG5047   476 QFIT--TYQHSSGTYRIRVTTVARMFTDGGLPKINRSfDQEAAAVFMARIAAFKAETEDIID 535
PLN00162 PLN00162
transport protein sec23; Provisional
 384-554 2.48e-14

transport protein sec23; Provisional


Pssm-ID: 215083 [Multi-domain]  Cd Length: 761  Bit Score: 77.67  E-value: 2.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  384 RCTLTSVPQTQALLNKAKLPLGLLLHPFKDLV-LPVVTSSTIvRCRSCRTYINPF--VNFlDQRRWKCNLCYRVNDVPEE 460
Cdd:PLN00162   13 RMSWNVWPSSKIEASKCVIPLAALYTPLKPLPeLPVLPYDPL-RCRTCRAVLNPYcrVDF-QAKIWICPFCFQRNHFPPH 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  461 FMYNPLTRVYGE--PhkrpevQNATIEFMAPSEYMLRPPqPPVYLFVFDVSHNAIETGYLNSvcqSLLDNLDLLPGNTRt 538
Cdd:PLN00162   91 YSSISETNLPAElfP------QYTTVEYTLPPGSGGAPS-PPVFVFVVDTCMIEEELGALKS---ALLQAIALLPENAL- 159

                         170
                  ....*....|....*.
gi 595763308  539 kIGFITFDSTIHFYSL 554
Cdd:PLN00162  160 -VGLITFGTHVHVHEL 174
Gelsolin pfam00626
Gelsolin repeat;
960-1035 3.66e-11

Gelsolin repeat;


Pssm-ID: 395501 [Multi-domain]  Cd Length: 76  Bit Score: 60.01  E-value: 3.66e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 595763308   960 TIPQPPILQLSVEKLSRDGAFLMDAGSLLMLWVGRNcsQNFLSQVLGVQNYASIPQTM-TDLPELDT-PESARIAAFI 1035
Cdd:pfam00626    1 KFVLPPPVPLSQESLNSGDCYLLDNGFTIFLWVGKG--SSLLEKLFAALLAAQLDDDErFPLPEVIRvPQGKEPARFL 76
Sec23-like cd01478
Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ...
 497-686 4.51e-05

Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 23 is very similar to Sec24. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup lack the consensus MIDAS motif but have the overall Para-Rossmann type fold that is characteristic of this superfamily.


Pssm-ID: 238755 [Multi-domain]  Cd Length: 267  Bit Score: 46.60  E-value: 4.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  497 PQPPVYLFVFDVSHNAIETGYLNSvcqSLLDNLDLLPGNTRtkIGFITFDSTIHFYSL---------------------- 554
Cdd:cd01478     1 TSPPVFLFVVDTCMDEEELDALKE---SLIMSLSLLPPNAL--VGLITFGTMVQVHELgfeecsksyvfrgnkdytakqi 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  555 --QEGLSQPQM----LIVSDIDDVFIPMPEN-LLVNLNESKELVQDLLKTL---PQMFTKTLETQSALGPALQAAFKLIS 624
Cdd:cd01478    76 qdMLGLGGPAMrpsaSQHPGAGNPLPSAAASrFLLPVSQCEFTLTDLLEQLqpdPWPVPAGHRPLRCTGVALSIAVGLLE 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 595763308  625 P----TGGRMSVFQTQLPTLGVGALKPREEPNQRSSAKEI------HLTPSTDFYKKLALDCSGQQAAVDLF 686
Cdd:cd01478   156 AcfpnTGARIMLFAGGPCTVGPGAVVSTELKDPIRSHHDIdkdnakYYKKAVKFYDSLAKRLAANGHAVDIF 227
PHA03247 PHA03247
large tegument protein UL36; Provisional
 5-367 8.05e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 8.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308    5 RIPAARGAAASLQAQNGAASASGSPYTNGPVHNTLMSPQVSSSQGYDSQPPGsyPRPMPAKTlnpfsaqsnyggsqgsgq 84
Cdd:PHA03247 2654 DDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPP--PTPEPAPH------------------ 2713

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308   85 tlnsPLVTSGPVLPSLHSGPVPRMPLPTSqnPAATPMPSGSFLPGANPPPPlnwqynypsTGPQTNHFPHVAPPTLP-GN 163
Cdd:PHA03247 2714 ----ALVSATPLPPGPAAARQASPALPAA--PAPPAVPAGPATPGGPARPA---------RPPTTAGPPAPAPPAAPaAG 2778

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  164 PNLTADHQYVSSGDPALQTSFKKPGSALPLQNPPLPPTFQPGAPPGPPPAGGPPPSRGPAPQKTPPRAAPPPSFNSAVNQ 243
Cdd:PHA03247 2779 PPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAP 2858

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  244 EG-ITSNANNGSTAAHNTYDEIEGGGFLATPQLVNQ-NPKTSRSVGSAYPSLPPGYQNSAPPVAGMPPPSLSYPSGPQAF 321
Cdd:PHA03247 2859 GGdVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRStESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR 2938

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 595763308  322 TQTPLGANHLTASMSGLSLHPEGLRVVNLLQERNMLPSTPLQPPVP 367
Cdd:PHA03247 2939 PQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAP 2984
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 16-180 1.50e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.91  E-value: 1.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308    16 LQAQNGAASASGSPYTNGPVHNTLMSPQVSSSQGYDSQPPGSYPRPMPAKTLNPFSAQSnyggsqgSGQTLNSPLvtsgp 95
Cdd:pfam03154  174 LQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQ-------QTPTLHPQR----- 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308    96 vLPSLHSG--PVPRMPLPTSQNPAATPMPSgsfLPGANPPPPLNWQynypsTGPqtNHFPHVAPPTLPGNPNLTADHQYV 173
Cdd:pfam03154  242 -LPSPHPPlqPMTQPPPPSQVSPQPLPQPS---LHGQMPPMPHSLQ-----TGP--SHMQHPVPPQPFPLTPQSSQSQVP 310


                   ....*..
gi 595763308   174 SSGDPAL 180
Cdd:pfam03154  311 PGPSPAA 317
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2-372 2.69e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 2.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308    2 AQPRIPAARGAAASLQAQNGAASASGSPYTNGPVHNTlmSPQVsssqgydsqPPGSYPRPMPAKTLNPFSAQSNYGGSQG 81
Cdd:PHA03247 2734 ALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPA--PPAA---------PAAGPPRRLTRPAVASLSESRESLPSPW 2802

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308   82 SGQTLNSPLVTSGPVLPSlHSGPVPRMPLPTSQNPAATPMPSGSflpganPPPPLNWQYNYPSTGPQTNHFPHVAPPTLP 161
Cdd:PHA03247 2803 DPADPPAAVLAPAAALPP-AASPAGPLPPPTSAQPTAPPPPPGP------PPPSLPLGGSVAPGGDVRRRPPSRSPAAKP 2875

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  162 GNPNltadHQYVSS-GDPALQTSFKKpgSALPLQNPPLPPTFQPGAPPGPPPAGGPPPSRGPAPQkTPPRAAPPPSFNSA 240
Cdd:PHA03247 2876 AAPA----RPPVRRlARPAVSRSTES--FALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPP-PPPRPQPPLAPTTD 2948

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308  241 vnqegiTSNANNGSTAAHNTYDEIEGGGFLATPQLVNQNPKTSRSVGSayPSLPPGYQNSAPPVAGMpPPSLSY----PS 316
Cdd:PHA03247 2949 ------PAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPA--SSTPPLTGHSLSRVSSW-ASSLALheetDP 3019

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 595763308  317 GPQAFTQT---PLGANHLTASMSGLSlHPEGLRVVNLLQERNMLPSTPLQPPVPNLLED 372
Cdd:PHA03247 3020 PPVSLKQTlwpPDDTEDSDADSLFDS-DSERSDLEALDPLPPEPHDPFAHEPDPATPEA 3077
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 7-135 6.64e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.01  E-value: 6.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763308    7 PAARGAAASLQAQNGAASASGSPYTNGPVHNTLMSPQVSSSQGYDSQPPGSYPRPMPAKTLNPFSAQSNYGGSQGSGQTL 86
Cdd:PHA03307  334 ESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPR 413

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 595763308   87 NSPLVTSGPvlpslHSGPVPRMPLPtsqnpaatpMPSGSFLPGANPPPP 135
Cdd:PHA03307  414 PSPLDAGAA-----SGAFYARYPLL---------TPSGEPWPGSPPPPP 448
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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