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Conserved domains on  [gi|558757331|ref|NP_001273930|]
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alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform c precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 71-298 1.22e-177

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467706  Cd Length: 229  Bit Score: 489.37  E-value: 1.22e-177
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  71 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEFVNRTPETVFIFWG 150
Cdd:cd23978    1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYRVLRRPQEFLNRTPETTLIFWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 151 PPSKMQKPQGS-LVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYG 229
Cdd:cd23978   81 PPNKMQKDGKSnLFRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSWLSTGWFTMVIAVELCDNVHVYG 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 558757331 230 MVPPNYCSQRPRLQRMPYHYYEPKGPDECVTYIQNEHSRKGNHHRFITEKRVFSSWAQLYGITFSHPSW 298
Cdd:cd23978  161 MVPPNYCSKRPTPKKMPYHYYEPKGPDECVTYIQNEHGRRGNHHRFITEKRVFARWAEHYNITFSHPSW 229
 
Name Accession Description Interval E-value
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 71-298 1.22e-177

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 489.37  E-value: 1.22e-177
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  71 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEFVNRTPETVFIFWG 150
Cdd:cd23978    1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYRVLRRPQEFLNRTPETTLIFWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 151 PPSKMQKPQGS-LVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYG 229
Cdd:cd23978   81 PPNKMQKDGKSnLFRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSWLSTGWFTMVIAVELCDNVHVYG 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 558757331 230 MVPPNYCSQRPRLQRMPYHYYEPKGPDECVTYIQNEHSRKGNHHRFITEKRVFSSWAQLYGITFSHPSW 298
Cdd:cd23978  161 MVPPNYCSKRPTPKKMPYHYYEPKGPDECVTYIQNEHGRRGNHHRFITEKRVFARWAEHYNITFSHPSW 229
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 68-251 7.34e-25

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 99.99  E-value: 7.34e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331   68 PSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVV-AHSSVFRVLRRPQEFVNRTPETVF 146
Cdd:pfam00777  40 NKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMnPESAIDSKYGNLGFSHPRDPFVEF 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  147 IF---------WGPPSKMQKPQGSLVRVIQRAGLVFPNmeayaVSPGRMRQFDDLFRGETGKDREKSHSW----LSTGWF 213
Cdd:pfam00777 120 VLvpfkgrdllWLPAFLTKGNVSRSLRVLYTLKEVKIP-----VDPDKVLFLHPDFLRYVANFWLRSHGLkgrrPSTGLL 194

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 558757331  214 TMVIAVELCDHVHVYGMVPPNYcsqrprLQRMPYHYYE 251
Cdd:pfam00777 195 MLSLALHLCDEVSLYGFGPFLD------SRGNSHHYYD 226
 
Name Accession Description Interval E-value
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 71-298 1.22e-177

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 489.37  E-value: 1.22e-177
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  71 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEFVNRTPETVFIFWG 150
Cdd:cd23978    1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYRVLRRPQEFLNRTPETTLIFWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 151 PPSKMQKPQGS-LVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYG 229
Cdd:cd23978   81 PPNKMQKDGKSnLFRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSWLSTGWFTMVIAVELCDNVHVYG 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 558757331 230 MVPPNYCSQRPRLQRMPYHYYEPKGPDECVTYIQNEHSRKGNHHRFITEKRVFSSWAQLYGITFSHPSW 298
Cdd:cd23978  161 MVPPNYCSKRPTPKKMPYHYYEPKGPDECVTYIQNEHGRRGNHHRFITEKRVFARWAEHYNITFSHPSW 229
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 71-296 5.73e-127

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 360.79  E-value: 5.73e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  71 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRP-QEFVNRTPETVFIFW 149
Cdd:cd23965    1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVSHSSLPRLLRNAiLLLAGTRAPTVVVFW 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 150 GPPSKMQKPQGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYG 229
Cdd:cd23965   81 GPETKMNKDGAGKYNLLRSLSKKYPDVEFYSLTPEKMDYADELFEKETGKSRIKSGTWLSTGWFTMLLALDVCDEIKVYG 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 558757331 230 MVPPNYCSQRPRlQRMPYHYYEPKGPDECVTYIQNEHSRKGnHHRFITEKRVFSSWAQLYGITFSHP 296
Cdd:cd23965  161 MVPENYCREHPN-SKVPYHYYEPGGLKECTYYNYHENALKG-GHRFITEKAVFARWAKKYNITFHHP 225
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 57-298 2.80e-108

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 314.50  E-value: 2.80e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  57 GYVPILGNKTLPSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQE 136
Cdd:cd23976    1 GYISIIDHKPLKMHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 137 FVNRTPETVFIFWGPPSKMQKP-QGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHSWLSTGWFTM 215
Cdd:cd23976   81 LLNVSQGTVFIFWGPSNYMRRDgKGLVYNNLQLMNQILPKLKVYTITRHKMLQFDELFKRETGKDRKISNTWLSTGWFTM 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 216 VIAVELCDHVHVYGMVPPNYCsQRPRLQRMPYHYYEPKGPDECVTYIQNEHSRKGNHHRFITEKRVFSSWAQLYGITFSH 295
Cdd:cd23976  161 IIALELCDRINVYGMVPPDFC-RDPNHPSVPYHYYEPSGPDECTMYISHERGRKGSHHRFITEKRVFANWARTFNIHFYQ 239


                 ...
gi 558757331 296 PSW 298
Cdd:cd23976  240 PDW 242
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 71-299 1.48e-84

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 253.63  E-value: 1.48e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  71 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEFVNRTPETVFIFWG 150
Cdd:cd23977    1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPLLLRNQGYFFQQSRDTKYVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 151 PPSKM-QKPQGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYG 229
Cdd:cd23977   81 PERNMdRDGGGKTYRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNETGKNRMKSGSFLSTGWFTMILALELCEEILVYG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 230 MVPPNYCSQRPRlQRMPYHYYEPKGPDECVTYIQNEHSRKGNhHRFITEKRVFSSWAQLYGITFSHPSWT 299
Cdd:cd23977  161 MVSDSYCRNKNH-SSVPYHYYEKGRLDECRMYLVHERAPRGG-HRFITEKAIFSRWAKRKKIRFAHPSWT 228
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 71-298 1.37e-78

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 238.29  E-value: 1.37e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  71 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEFVNRTPETVFIFWG 150
Cdd:cd23975    1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPLLLKNPDYFFKETNETIYVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 151 PPSKMQKP-QGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYG 229
Cdd:cd23975   81 PFRNMRKDgKGIVYNMLKKAVESYPQAKIYVTTEKRMSYCDTVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHVYG 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 558757331 230 MVPPNYCSQRPrLQRMPYHYYEPkGPDECVTYIQNEHSRKGNhHRFITEKRVFSSWAQLYGITFSHPSW 298
Cdd:cd23975  161 MINDTYCKTEG-YRKVPYHYYEP-GRDECDEYFLHENAPYGG-HRFITEKKVFAKWAKKHPITFTHPNW 226
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 74-285 7.52e-35

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 124.78  E-value: 7.52e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  74 CVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEFVNRTP---ETVFIFWG 150
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGCHPLPleeEVVLILSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 151 PPSKMQKpqgslvRVIQRAGLvfPNMEAYAVSPGR---MRQFDDLFRGETGKDrEKSHSWLSTGWFTMVIAVELCDHVHV 227
Cdd:cd19952   81 AAAADFK------RLKRRKKR--HDNAVLLLTDPApdlLSYVRKRLEKLGLKS-FFGGNAPSSGLLAVLLALQLCDSVDL 151

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 558757331 228 YGMVPPNYCSqrprlQRMPYHYYEPKGPdecvtyiqnehSRKGNHHRFITEKRVFSSW 285
Cdd:cd19952  152 YGFGVDSGHA-----PKVPYHYYDLVEA-----------EEGTAVHSFDLEAELLRAL 193
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 68-251 7.34e-25

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 99.99  E-value: 7.34e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331   68 PSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVV-AHSSVFRVLRRPQEFVNRTPETVF 146
Cdd:pfam00777  40 NKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMnPESAIDSKYGNLGFSHPRDPFVEF 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  147 IF---------WGPPSKMQKPQGSLVRVIQRAGLVFPNmeayaVSPGRMRQFDDLFRGETGKDREKSHSW----LSTGWF 213
Cdd:pfam00777 120 VLvpfkgrdllWLPAFLTKGNVSRSLRVLYTLKEVKIP-----VDPDKVLFLHPDFLRYVANFWLRSHGLkgrrPSTGLL 194

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 558757331  214 TMVIAVELCDHVHVYGMVPPNYcsqrprLQRMPYHYYE 251
Cdd:pfam00777 195 MLSLALHLCDEVSLYGFGPFLD------SRGNSHHYYD 226
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 70-253 4.33e-24

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 96.98  E-value: 4.33e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  70 RCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFrvlRRPQEFvnrTPETVFIF- 148
Cdd:cd23967    1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAF---RDPEEY---DSDWLLVLv 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 149 --------WGPPSKMQKPQGSLVRVIQRAGLVFPnmeayaVSPGRMRQFDDLFRGETG-------KDREKSHSWLSTGWF 213
Cdd:cd23967   75 pfksmdllWLQAVIKGKKPNGKGGFWKKIATSVP------KPPKKIRILNPYILQEAAfdliglpMNGKQGKNVPTTGII 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 558757331 214 TMVIAVELCDHVHV----YGMVPPNycsqrprlqrMPYHYYEPK 253
Cdd:cd23967  149 AIVMALHYCDEVDIagfgYDPSDPN----------APLHYYDSL 182
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 38-252 3.85e-21

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 90.41  E-value: 3.85e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  38 SLRGRSRRPVNLKKWSitdgYVPILGNKTLPSRCHQ-CVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNK 116
Cdd:cd23968   15 STLRKTTSPFKDLLSL----RYPFPESSLENTKRYNtCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSK 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 117 TTYRVVAH----SSVFRVLRRPqEFVNrtpETVFIfWGPPS-------KMQKPQGSLVRVIQRAGLVFPNMEAYAVSPGR 185
Cdd:cd23968   91 TTLRLINSqilsKPEFNFLTDP-LYRN---VTLLV-WDPSSynvnlekWYKKPDFDFFPNYIKYRRRHPEEPFYLIDPRF 165

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 558757331 186 M-RQFDDLFRGETGKDREKSHswlSTGWFTMVIAVELCDHVHVYGMVPPNYCSQRprlqrmpYHYYEP 252
Cdd:cd23968  166 LwRLWDILQEYTPEKIKPNPP---SSGFIGIVLMLHLCDWVDVYEYVPSVRQTDR-------CHYYDV 223
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 36-278 4.95e-21

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 90.01  E-value: 4.95e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  36 YGSLRGRSRRPVNLKKWSITDGYVPIlGNKTLPSrchqCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGN 115
Cdd:cd23963   33 YYSYFKKKTFKITKSLYELLPKTSPF-SHKRYKT----CAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGR 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 116 KTTYRVVAHSSVFRVL------RRPQEFVNRTPETV-FIFWGPPSKMQKPQGSLVRVIQRAGLVFPNME-AYAvSPGRMR 187
Cdd:cd23963  108 KTNLTTLNPSILKRRYnslkknRDRDKFLNRLKEYNgSILWYPKFSFKSSTNLLLKAARALKKNGLNLTvVYS-NPEHFL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 188 QFDDlFRGETGKDRekshsWLSTGWFTMVIAVELCDHVHVYGMVPpnYcSQRPRLQRMPYHYYEPkgpdecvtyiqNEHS 267
Cdd:cd23963  187 AVQK-FWKRRGLEK-----RPSTGLYLVSLALTFCDEIHLYGFWP--F-PTDPNGRPVPYHYYDD-----------LSPS 246

                        250
                 ....*....|.
gi 558757331 268 RKGNHHRFITE 278
Cdd:cd23963  247 TKNKVHNMPEE 257
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 46-251 4.60e-18

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 81.68  E-value: 4.60e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  46 PVNLKKWsitDGYVPILGNKTLPSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVaHS 125
Cdd:cd23985   23 PFNTSEW---EGYLPKKSLREEVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLI-NS 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 126 SVfrVLRRPQEFVNRT--PETVFIFWGP-------PSKMQKPQGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGE 196
Cdd:cd23985   99 QL--VTTEKHKFLKDSlyNEGILIVWDPapyhsdiPEWYKNPDYNFFENYKTYRRLNPNQPFYILHPQMQWELWDIIQEN 176

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 558757331 197 TGKDREKSHSwlSTGWFTMVIAVELCDHVHVYGMVPpnycSQRprlQRMPYHYYE 251
Cdd:cd23985  177 SPEEIQPNPP--SSGMLGIILMMTLCDQVDVYEFLP----SKR---KTDVCHYYQ 222
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 58-251 5.29e-17

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 79.11  E-value: 5.29e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  58 YVP-ILGNKTLPSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHssvfRVLRRPQE 136
Cdd:cd23986   35 YVPkIPLSKLHLRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINS----QILTNPNH 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 137 FVNRTP---ETVFIFWGP-PSKM------QKPQGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHS 206
Cdd:cd23986  111 HFIDSSlykDVILVAWDPaPYSAnlhkwyKKPDYNLFTPYVQYRKRNPNQPFYILHPKFIWQLWDIIQENTQEKIQPNPP 190

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 558757331 207 wlSTGWFTMVIAVELCDHVHVYGMVPpnycSQRprlQRMPYHYYE 251
Cdd:cd23986  191 --SSGFIGILIMMSMCREVHVYEYIP----SVR---QTDLCHYHE 226
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 70-251 2.86e-14

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 70.08  E-value: 2.86e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  70 RCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVV-AHSSVFrvlrRPQEfvNRTPETVF-- 146
Cdd:cd23982    1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFyPESAQF----DPGI--ENDPDTLLvl 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 147 -----------------------IFWGPPSKMQKPQGSLVRVIqraglvfpnmeayavSPGRMRQFDDLFRGETGKDREK 203
Cdd:cd23982   75 vpfkpldfywlyeilsnekrvrkGFWKQPPRIWDANPKQIRIL---------------NPYYTYVAATKLLQVPGQRKKK 139

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 558757331 204 SHSwlSTGWFTMVIAVELCDHVHVYGMVPPNycsqrPRLQRMPYHYYE 251
Cdd:cd23982  140 QKP--TTGLLAITLALHLCDEVHIAGFGYPD-----NGNSNQPIHYYN 180
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 68-230 3.90e-13

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 68.08  E-value: 3.90e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  68 PSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVahssvfrvlrRPQEFVNRTPETVFI 147
Cdd:cd23966   74 PNRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFM----------YPESAVDLDPGVHLV 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 148 FWgpPSKMQKPQ--------GSLVRviqraglvfpnmeayavSPGRMRQFDDLfrgetgkDREK-----------SH-SW 207
Cdd:cd23966  144 LV--PFKVLDLQwlisalttGEITR-----------------TYTPVKRFIKA-------DKDKvlvinpafikyVHdNW 197

                        170       180       190
                 ....*....|....*....|....*....|
gi 558757331 208 L-------STGWFTMVIAVELCDHVHVYGM 230
Cdd:cd23966  198 TehhgrypSTGFLALIFALHICDEVSVFGF 227
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 71-251 7.67e-13

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 66.30  E-value: 7.67e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  71 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVV------------AHSSVF-RVLRRPQEF 137
Cdd:cd23983    2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTypegapkseqeyDPTSLFvAVLFKSVDF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 138 ------VNRTPETV---FIFWGppskmqkpqgslvRVIQRAGLvfpnmeayavSPGRMRQFDDLFRGETGKD----REKS 204
Cdd:cd23983   82 awlkamVKKEPLSFwsrLFFWK-------------EVADSIPL----------KPSQFRILNPLIIKETALDilqyPEPQ 138

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 558757331 205 HSWLS-------TGWFTMVIAVELCDHVHVYGMvppNYCSQRPRLqrmPYHYYE 251
Cdd:cd23983  139 SRLWGwdknvptLGVTAVVLATHLCDEVSLAGF---GYDLSQPHA---PLHYYD 186
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 42-229 1.67e-11

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 63.36  E-value: 1.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  42 RSRRPVNLKK-----WSITDGYVPILGNKTlPSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNK 116
Cdd:cd23980   48 REKKPKNLNDtirelFQVVPGNVDPLLEKR-LVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSK 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 117 TTYRVVAHSSvFRVLRRPQEFVNRTPETVFIFW-------GPPSKMQKPQGSLVRVIQRAGLVFpnmeayavSPGRMRQF 189
Cdd:cd23980  127 TTHHFVYPES-FRELAQNVSMILVPFKTLDLEWvisatttGTISHTYVPVPRKIKVKKEKILIY--------HPAFIKYV 197

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 558757331 190 DDLFRGETGKdrekshsWLSTGWFTMVIAVELCDHVHVYG 229
Cdd:cd23980  198 FDRWLQGHGR-------YPSTGILSVIFSLHVCDEVDLYG 230
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 74-254 5.25e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 62.05  E-value: 5.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  74 CVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYrVVAHSSVfrVLRRPQEFVNRTPETVF------- 146
Cdd:cd23969   67 CAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNL-TTMNPSV--IPHAYGDLVNATDKEKFverlrql 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 147 ---IFWgPPSKMQKPQGSLVRVIQRAGL--VFPNMEAYAvsPGRMRQfddLFRG--ETGKDREKSHswlSTGWFTMVIAV 219
Cdd:cd23969  144 gdsILW-IPAFVSKGGEEHVQWTNEIILkhKLNVKTAYP--PLRLNH---AIRGywLTTKFRIKRP---STGLLMYTLAT 214

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 558757331 220 ELCDHVHVYGMVPpnyCSQRPRLQRMPYHYYEPKG 254
Cdd:cd23969  215 RFCDEIHLYGFYP---FSEDGNGRAVKYHYYDNRK 246
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 74-254 8.67e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 61.26  E-value: 8.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  74 CVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVA-------HSSVFRVLRRPQEFVNRTPETVF 146
Cdd:cd23970   71 CAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNpsilekyYNNLLTIQDRNNFFLSLKKLDGA 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 147 IFWGPPSKMQKpqgslVRVIQRAGLVF-------PNME-AYavsPGR-MRQFDDLFRGETGKDREkshswLSTGWFTMVI 217
Cdd:cd23970  151 ILWIPAFFFHT-----SATVTRTLVDFfvehrgqLKVQlAW---PGNiMQHVNRYWKTKHLSPKR-----LSTGILMYTL 217

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 558757331 218 AVELCDHVHVYGMVPpnyCSQRPRLQRMPYHYYEPKG 254
Cdd:cd23970  218 ASAICEEIHLYGFWP---FGFDPTGTPLPYHYYDKKG 251
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 71-251 1.37e-10

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 59.76  E-value: 1.37e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  71 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVF-------------------RVL 131
Cdd:cd23984    2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFsdpshydpnttvvlipfkpHDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 132 RRPQEFVNRTPETVFIFW-GPPSKMQ-KPqgSLVRVIqraglvfpnmeayavSPGRMRQFD-DLFRGETGKDREKSHSWL 208
Cdd:cd23984   82 RWLLDLLMGKKVSAKGFWkKPALNLIyKP--NQIRIL---------------NPFILRIAAyELLHFPKRFPKEKKPKHP 144

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 558757331 209 STGWFTMVIAVELCDHVHVYGMvppnycsqRPRLQRM--PYHYYE 251
Cdd:cd23984  145 TTGIIAITLALHICNEVHIAGF--------KYDFSNLnsTLHYYG 181
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 73-255 2.27e-10

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 59.96  E-value: 2.27e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  73 QCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTgYSADVGNKTTYrVVAHSSVFR-----VLRRPQEFVNRtpetvfi 147
Cdd:cd23971   66 TCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKTNL-VTANPSILRekfhnLKKRRRPFVER------- 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 148 fwgppskMQKPQGSLV------------------RVIQRAGlvfPNMEAYAVSPGRMRQFDDLFRGETGKDREkshswLS 209
Cdd:cd23971  137 -------MKVYGNALLllpafsytsntepslralYTLEDFG---SPQKVLFFNPEYLRNLSRYWKSKGLKARR-----LS 201

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 558757331 210 TGwFTMV-IAVELCDHVHVYGMVPpnyCSQRPRLQRMPYHYYEPKGP 255
Cdd:cd23971  202 TG-LMLVsAALELCENVHLYGFWP---FSTDLDGNPISHHYYDNVLP 244
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 62-251 7.42e-10

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 58.41  E-value: 7.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  62 LGNKTLPSrchqCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYrVVAHSSVfrVLRRPQEFVNRT 141
Cdd:cd23987   59 LKNKHFKT----CAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDL-VTMNPSV--VQRAFEDLVNET 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 142 PETVFIfwgppSKMQKPQGSLVRViqraglvfpnmEAYAVSPG--RMRQFDDLFRGETGKDREKSHS----------WL- 208
Cdd:cd23987  132 WKEKFL-----QRLQSLNGSILWI-----------PAFMAKGGeeRVEWVNDLILKHHINVRTAYPSlrllhavrgyWLt 195

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 558757331 209 --------STGWFTMVIAVELCDHVHVYGMVP-PNYCSQRPrlqrMPYHYYE 251
Cdd:cd23987  196 nkvhikrpTTGLLMYTLATRFCNRIHLYGFWPfPRDQNQNP----VKYHYYD 243
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 68-229 7.98e-10

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 58.34  E-value: 7.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  68 PSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVfRVLRRPQEFVNRTPETVFI 147
Cdd:cd23979   77 PSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESA-KNLPANVSFVLVPFKTLDL 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 148 FW-------GPPSKMQKPQGSLVRVIQRAGLVFpnmeayavSPGRMRQFDDLFRGETGKdrekshsWLSTGWFTMVIAVE 220
Cdd:cd23979  156 LWitsalstGQIRFTYAPVKQFLRVDKDKVQIY--------NPAFFKYIHDRWTEHHGR-------YPSTGMLVLFFALH 220


                 ....*....
gi 558757331 221 LCDHVHVYG 229
Cdd:cd23979  221 VCDEVNVYG 229
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 69-289 9.04e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 58.61  E-value: 9.04e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  69 SRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEF----VNRTPET 144
Cdd:cd23973   81 DGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAHSITSSLMILQKRgfknIPQDKDI 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 145 VFIF---------WGPPSKMQK--PQGSLVRVIQRA--GLVFpNMEAYAVS-PGRMRQFDDLFRgeTGKDREKSHSWL-- 208
Cdd:cd23973  161 KYILfpegprdyqWLEALLKNKtiPSGAYYGRRPRSyfSGDF-TEDKYLVLhPDFLRYVKNRFL--RSKTLKGKYWAIyr 237

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 209 -STGWFTMVIAVELCDHVHVYGMVPPNYcsqrprlQRMPYHYYEpKGPDECVTYIqnehsrkgnHHRFITEKRVfssWAQ 287
Cdd:cd23973  238 pTTGAFLLLTALHLCDTVSAYGFITEDY-------RKYPDHYYD-KKKTKLVFYI---------NHDFRLEKKL---WKR 297


                 ..
gi 558757331 288 LY 289
Cdd:cd23973  298 LH 299
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 6-251 7.01e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 55.73  E-value: 7.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331   6 EQRSAVFVILFALITILILYSSNSANEVFHYGSLRgrsRRPVNLKK--WSITDGYVPiLGNKTLPSrchqCVIVSSSSHL 83
Cdd:cd23988    5 EIRKDILRFLDAERDVSVVKSSFKPGDVIHYVLDR---RRTLNISQnlHSLLPEVSP-MKNRRFKT----CAVVGNSGIL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  84 LGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRV---LRRP---QEFVNRTPE-TVFIFWgPPSKMQ 156
Cdd:cd23988   77 LDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAfggFRNEsdrEKFVHRLSMlNDSVLW-IPAFMV 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 157 KpqGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLfRGE--TGKDREKSHswlSTGWFTMVIAVELCDHVHVYGMVP-P 233
Cdd:cd23988  156 K--GGEKHVEWVNALILKNKLKVRTAYPSLRLIHAV-RGYwlTNKVNIKRP---STGLLMYTLATRFCDEIHLYGFWPfP 229

                        250
                 ....*....|....*...
gi 558757331 234 NYCSQRPrlqrMPYHYYE 251
Cdd:cd23988  230 KDANGNP----VKYHYYD 243
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 70-150 1.33e-08

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 54.16  E-value: 1.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  70 RCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSvfrVLRRPQEFvnrTPETVFIFW 149
Cdd:cd23981    1 SCRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEG---AIQKPEQY---EKDSLFVLA 74


                 .
gi 558757331 150 G 150
Cdd:cd23981   75 G 75
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 68-291 1.53e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 54.57  E-value: 1.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  68 PSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPqefVNRTPETVFI 147
Cdd:cd23964   79 RPRCIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPESLHNSLLKH---VPQDKDTKYL 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 148 F----------------WGPPSKMQKPQGSlvrviqraglvFPNMEAYAVSPGRMRQFD-DLFRgetgkdreksH---SW 207
Cdd:cd23964  156 FipfkirdydyldavlsGKPVPDGCDKGKR-----------PPPLFGPKLNATNVRLLHpDFIR----------YlfnRW 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 208 L--------STGWFTMVIAVELCDHVHVYGM-VPPNYcsqrprlqrmPYHYYEPKgpdecvtyIQNEHSRKGNHHrFITE 278
Cdd:cd23964  215 LnsstsyrpTTGALMLLTALHTCDQVSVYGFgYDPRF----------SLHYYDKT--------FVKFTVFYANHD-FTNE 275

                        250
                 ....*....|....*
gi 558757331 279 KRVfssWAQL--YGI 291
Cdd:cd23964  276 RKL---WRKLheEGI 287
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 73-268 2.68e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 53.99  E-value: 2.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  73 QCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTG-YSADVGNKTTYrVVAHSSVFrvLRRPQEFVNRtpetvfifwgp 151
Cdd:cd23991   66 QCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNL-VTANPSII--SIKYAKLNER----------- 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 152 pskmQKPQGSLVRVIQRAGLVFPnmeAYAVSPGRMRQFDDLFRGETGKDREK------------SHSW---------LST 210
Cdd:cd23991  132 ----RKPFLETVSVYGDAFLLLP---AFSYRSNTALSFKVYYTLEDFKAKQKviffhpiylkhlAQFWrskgvqvyrLST 204

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 558757331 211 GWFTMVIAVELCDHVHVYGMVPpnyCSQRPRLQRMPYHYYEPKGPDECVTYIQNEHSR 268
Cdd:cd23991  205 GLMITSAALELCEEVKLYGFWP---FSKNTEGKPISHHYYDNQLPKPGFHSMPKEFYQ 259
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 67-256 4.15e-07

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 50.21  E-value: 4.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  67 LPSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAP-TTGYSADVGNKTtYRVVAHSSVFR-----VLRRPQEFVnr 140
Cdd:cd23989   59 LQLPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPlSREYTDDVGTKT-QLVTANPSIIDkrfqnLLWSRKSFV-- 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 141 tpETVFIF-----WGPPSKMQKPQGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFddlfrGETGKDREKSHSWLSTGWFTM 215
Cdd:cd23989  136 --ESMKVYgrsyiYMPAFSMKTGTDPSLRVYYTLADVGANQTVLFANPNFLRNV-----GKFWKSKGVHAKRLSTGLFLV 208

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 558757331 216 VIAVELCDHVHVYGMVPpnyCSQRPRLQRMPYHYYEPKGPD 256
Cdd:cd23989  209 SAALGLCEEVTIYGFWP---FSVDLDERTISHHYYDNVLPD 246
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 67-253 4.39e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 50.59  E-value: 4.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  67 LPSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEF-VNRTPET- 144
Cdd:cd23972   78 TPGKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTSFYGFTVNTMKNSLISYWNLgFTRTPQGq 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 145 ----VFIfwgpPSKMQK-------------PQGsLVRVIQRAGLVFPNMEAYA---VSPGRMRQFDDLFRGETGKDREKS 204
Cdd:cd23972  158 dlqyIFI----PSDIRDyvmlrsailgvpvPEG-LDKGDRPHKYFGPEASAKKfklLHPDFISYLTDRFLKSKLLNTHYG 232

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 558757331 205 HSWL-STGWFTMVIAVELCDHVHVYGMVPPNYcsqrprlQRMPYHYYEPK 253
Cdd:cd23972  233 HLYMpSTGALMLLTALHTCDQVSAYGFITSNY-------WKFSDHYYERK 275
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 69-253 2.83e-05

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 44.74  E-value: 2.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331  69 SRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRR---------PQefvn 139
Cdd:cd23974   82 SPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNTLMNSLRAyagvgfngpPQ---- 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 140 rTPETVFIFWgP---------------------PSKMQKPQ---GSLVRViqraglvfpnmEAYAV-SPGRMRQFDDLF- 193
Cdd:cd23974  158 -SKETRYIFL-PdhdrdyllvkaalthtpidrgRDKSKRPSkyfGKDVTA-----------EKFKIyHPDFIRYLRNRFl 224

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757331 194 RGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYGMVPPNYcsqrprlQRMPYHYYEPK 253
Cdd:cd23974  225 WSPILNTKQRDIYRPSTGAVMLLAALHTCDQVSAYGFMTPDY-------GKYSDHYYDKT 277
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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