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Conserved domains on  [gi|557357663|ref|NP_001273446|]
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adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform e [Homo sapiens]

Protein Classification

nucleotide-sugar transporter family protein( domain architecture ID 706892)

nucleotide-sugar transporter family protein may mediate the transport of nucleotides or sugars or their derivatives; belongs to the drug/metabolite transporter (DMT) superfamily

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UAA super family cl26745
UAA transporter family; This family includes transporters with a specificity for ...
 6-307 4.64e-69

UAA transporter family; This family includes transporters with a specificity for UDP-N-acetylglucosamine.


The actual alignment was detected with superfamily member pfam08449:

Pssm-ID: 462479 [Multi-domain]  Cd Length: 307  Bit Score: 217.55  E-value: 4.64e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357663    6 KLLFCATGLQVSYLTWGVLQERVMTRSYGATatspGERFTDSQFLvlmnrvlALIVAGLSCVLCK-----QPRHGAPMYR 80
Cdd:pfam08449   1 QFLLAVSGVFGGCCSNGVLQELIMKVEPGPF----GNLLTFAQFL-------FYALEGLPESIDIftskfLKPRKIPLKT 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357663   81 YSFASLSNVLSSWCQYEALKF-VSFPTQVLAKASKVIPVMLMGKLVSRRSYEHWEYLTATLISIGVSMFLLSSGPEP--- 156
Cdd:pfam08449  70 YVILVALFFITSVLNNEALKYdISYPTHIIFRSSKLIPVMIMGILILGKRYSKLQYLSAFLVTLGIIIFTLFSAKDKvad 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357663  157 -RSSPATTLSGLILLAGYIAFDSFTSNWQDALF-AYKMSSVQMMFGVNFFSCLFTvgsLLEQGALLEGTRFMGRHSEFAA 234
Cdd:pfam08449 150 sVVSPNFFLIGIAMLSGALLLDAFLGNYQEKTYkKYGKHSKEMLFYSHLLSLPFF---LLLQGDLFSAVQFCSQSPDKAV 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357663  235 --------HALLLSICSACGQLFIFYTIGQFGAAVFTIIMTLRQAFAILLSCLLYGHTVTVVGGLGVAVVFAALLLRVYA 306
Cdd:pfam08449 227 lslpsmlfYLLLNVLTQYVCIRGVFILISEFGALTVTLVTTLRKFVSLLLSILLFGNPFTLQHWVGTLLVFLGTFLYSYS 306


                  .
gi 557357663  307 R 307
Cdd:pfam08449 307 K 307
 
Name Accession Description Interval E-value
UAA pfam08449
UAA transporter family; This family includes transporters with a specificity for ...
 6-307 4.64e-69

UAA transporter family; This family includes transporters with a specificity for UDP-N-acetylglucosamine.


Pssm-ID: 462479 [Multi-domain]  Cd Length: 307  Bit Score: 217.55  E-value: 4.64e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357663    6 KLLFCATGLQVSYLTWGVLQERVMTRSYGATatspGERFTDSQFLvlmnrvlALIVAGLSCVLCK-----QPRHGAPMYR 80
Cdd:pfam08449   1 QFLLAVSGVFGGCCSNGVLQELIMKVEPGPF----GNLLTFAQFL-------FYALEGLPESIDIftskfLKPRKIPLKT 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357663   81 YSFASLSNVLSSWCQYEALKF-VSFPTQVLAKASKVIPVMLMGKLVSRRSYEHWEYLTATLISIGVSMFLLSSGPEP--- 156
Cdd:pfam08449  70 YVILVALFFITSVLNNEALKYdISYPTHIIFRSSKLIPVMIMGILILGKRYSKLQYLSAFLVTLGIIIFTLFSAKDKvad 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357663  157 -RSSPATTLSGLILLAGYIAFDSFTSNWQDALF-AYKMSSVQMMFGVNFFSCLFTvgsLLEQGALLEGTRFMGRHSEFAA 234
Cdd:pfam08449 150 sVVSPNFFLIGIAMLSGALLLDAFLGNYQEKTYkKYGKHSKEMLFYSHLLSLPFF---LLLQGDLFSAVQFCSQSPDKAV 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357663  235 --------HALLLSICSACGQLFIFYTIGQFGAAVFTIIMTLRQAFAILLSCLLYGHTVTVVGGLGVAVVFAALLLRVYA 306
Cdd:pfam08449 227 lslpsmlfYLLLNVLTQYVCIRGVFILISEFGALTVTLVTTLRKFVSLLLSILLFGNPFTLQHWVGTLLVFLGTFLYSYS 306


                  .
gi 557357663  307 R 307
Cdd:pfam08449 307 K 307
 
Name Accession Description Interval E-value
UAA pfam08449
UAA transporter family; This family includes transporters with a specificity for ...
 6-307 4.64e-69

UAA transporter family; This family includes transporters with a specificity for UDP-N-acetylglucosamine.


Pssm-ID: 462479 [Multi-domain]  Cd Length: 307  Bit Score: 217.55  E-value: 4.64e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357663    6 KLLFCATGLQVSYLTWGVLQERVMTRSYGATatspGERFTDSQFLvlmnrvlALIVAGLSCVLCK-----QPRHGAPMYR 80
Cdd:pfam08449   1 QFLLAVSGVFGGCCSNGVLQELIMKVEPGPF----GNLLTFAQFL-------FYALEGLPESIDIftskfLKPRKIPLKT 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357663   81 YSFASLSNVLSSWCQYEALKF-VSFPTQVLAKASKVIPVMLMGKLVSRRSYEHWEYLTATLISIGVSMFLLSSGPEP--- 156
Cdd:pfam08449  70 YVILVALFFITSVLNNEALKYdISYPTHIIFRSSKLIPVMIMGILILGKRYSKLQYLSAFLVTLGIIIFTLFSAKDKvad 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357663  157 -RSSPATTLSGLILLAGYIAFDSFTSNWQDALF-AYKMSSVQMMFGVNFFSCLFTvgsLLEQGALLEGTRFMGRHSEFAA 234
Cdd:pfam08449 150 sVVSPNFFLIGIAMLSGALLLDAFLGNYQEKTYkKYGKHSKEMLFYSHLLSLPFF---LLLQGDLFSAVQFCSQSPDKAV 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357663  235 --------HALLLSICSACGQLFIFYTIGQFGAAVFTIIMTLRQAFAILLSCLLYGHTVTVVGGLGVAVVFAALLLRVYA 306
Cdd:pfam08449 227 lslpsmlfYLLLNVLTQYVCIRGVFILISEFGALTVTLVTTLRKFVSLLLSILLFGNPFTLQHWVGTLLVFLGTFLYSYS 306


                  .
gi 557357663  307 R 307
Cdd:pfam08449 307 K 307
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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