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Conserved domains on  [gi|557129025|ref|NP_001273384|]
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solute carrier family 22 member 23 isoform b [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-324 2.73e-156

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17444:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 364  Bit Score: 445.06  E-value: 2.73e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025   1 MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWS 80
Cdd:cd17444   91 MFSTLRFFEGFCLAGIILSLYALRIELCPPGHRFMITMVASFIAMAGQFLMPGLAALCRDWQVLQAVIICPFLLMLSYWC 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025  81 IFPeslrwlmatqqfesakrlilhftqknrmnpegdikgvipelekelsrrpkkvcivkvvgtrnlwKNIVVLCVNSLTG 160
Cdd:cd17444  171 IFP----------------------------------------------------------------KNIVVLCVNSLTG 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025 161 YGIHHCFARSMMGHEVKVPLLENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLNLIGKYS 240
Cdd:cd17444  187 YGIHHCFAKSMMDHEMKGSFLHNFYAEYYTMAVIALASCLAMCPVVGFLGRRGGLLLFMILTALASLLQLGLLNLIGKYS 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025 241 QHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHH 320
Cdd:cd17444  267 QHPDSGMSDEVKDKFSVTFSIVGMFSSHAVGSLSVFFCAEITPTVIRGGGLGLVLASAGFGMLTAPIMELHNQKGYFLHH 346


                 ....
gi 557129025 321 IIFA 324
Cdd:cd17444  347 IIFA 350
 
Name Accession Description Interval E-value
MFS_SLC22A23 cd17444
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ...
 1-324 2.73e-156

Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341002 [Multi-domain]  Cd Length: 364  Bit Score: 445.06  E-value: 2.73e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025   1 MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWS 80
Cdd:cd17444   91 MFSTLRFFEGFCLAGIILSLYALRIELCPPGHRFMITMVASFIAMAGQFLMPGLAALCRDWQVLQAVIICPFLLMLSYWC 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025  81 IFPeslrwlmatqqfesakrlilhftqknrmnpegdikgvipelekelsrrpkkvcivkvvgtrnlwKNIVVLCVNSLTG 160
Cdd:cd17444  171 IFP----------------------------------------------------------------KNIVVLCVNSLTG 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025 161 YGIHHCFARSMMGHEVKVPLLENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLNLIGKYS 240
Cdd:cd17444  187 YGIHHCFAKSMMDHEMKGSFLHNFYAEYYTMAVIALASCLAMCPVVGFLGRRGGLLLFMILTALASLLQLGLLNLIGKYS 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025 241 QHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHH 320
Cdd:cd17444  267 QHPDSGMSDEVKDKFSVTFSIVGMFSSHAVGSLSVFFCAEITPTVIRGGGLGLVLASAGFGMLTAPIMELHNQKGYFLHH 346


                 ....
gi 557129025 321 IIFA 324
Cdd:cd17444  347 IIFA 350
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 1-347 3.06e-25

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 107.41  E-value: 3.06e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025    1 MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWS 80
Cdd:TIGR00898 182 VFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSW 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025   81 IFPESLRWLMATQQFESAKRLILHFTQKNRMNPEGDIKgvIPELEKELSRRPKKVCIVKVVGTRNL-WKNIVVLCV---N 156
Cdd:TIGR00898 262 FVPESPRWLISQGRIEEALKILQRIAKINGKKLPAEVL--SLSLEKDLSSSKKQYSFLDLFRTPNLrKTTLCLMMLwftT 339

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025  157 SLTGYGIhhcfarsMMGHEVkvpLLENFYADYYTTASIALVSCLAMCVVVRFLGRR----------GGLLLFMILTALAS 226
Cdd:TIGR00898 340 AFSYYGL-------VLDLGN---LGGNIYLDLFISGLVELPAKLITLLLIDRLGRRytmaaslllaGVALLLLLFVPVDL 409

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025  227 LLQLGLLNLIGKYSqhpdsgmsdsvkdkFSIAFSIVGMFAshavgslsvffcAEITPTVIRCGGLGLVLASAGFGMLTAP 306
Cdd:TIGR00898 410 YFLRTALAVLGKFG--------------ITSAFQMVYLYT------------AELYPTVVRNLGVGVCSTMARVGSIISP 463

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 557129025  307 IIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPE 347
Cdd:TIGR00898 464 FLVYLGEKWLFLPLVLFGGLALLAGILTLFLPETKGVPLPE 504
Sugar_tr pfam00083
Sugar (and other) transporter;
6-324 4.44e-05

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 45.34  E-value: 4.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025    6 RFFEGFCLAGIILTLYALRIELCPPGKR-FMITMVASFVAMaGQFLMPGLA---ALCRD---WQVLQALIICPFLLMLLY 78
Cdd:pfam00083 109 RVLVGIGVGGASVLAPMYISEIAPKKLRgALGSLYQLAITF-GILLAYIFGlglNKTSNsdgWRIPLGLQLVPALLLIIG 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025   79 WSIFPESLRWLMATQQFESAKRLIlhftqKNRMNPEGDIKGVIPELEK-ELSRRPKKVCIVKVVGTRNLWKNIVVLCV-- 155
Cdd:pfam00083 188 LLFLPESPRWLVEKGRLEEAREVL-----AKLRGVPDVDRELDEIKDSlEAGQEAEKASWKELFSTKTRRQRLLIGVMlq 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025  156 --------NSLTGYGihhcfarSMMGHEVKVPllenfyADYYTTASIALVSCLAMCV---VVRFLGRRgGLLLFMILTAL 224
Cdd:pfam00083 263 ifqqltgiNAIFYYS-------TTIFENLGLS------DSFLVTIIVGVVNFVFTFIaifLVDRFGRR-PLLLLGAAGMA 328

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025  225 ASLLQLGLLNLIGKYSQHPDSGmsdsvkdkFSIAFsIVGMFASHAVGSLSVFF--CAEITPTVIRCGGLGLVLAS---AG 299
Cdd:pfam00083 329 ICFVILGIVALLGVSKSDWAGI--------VAIVF-IALFIAFFAMGWGPVPWviVSELFPLSVRSKAMALATAAnwlAN 399

                         330       340
                  ....*....|....*....|....*..
gi 557129025  300 F--GMLTAPIIELHNQKGYFlhhIIFA 324
Cdd:pfam00083 400 FliGFLFPIITDAIGLGYTF---FIFA 423
 
Name Accession Description Interval E-value
MFS_SLC22A23 cd17444
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ...
 1-324 2.73e-156

Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341002 [Multi-domain]  Cd Length: 364  Bit Score: 445.06  E-value: 2.73e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025   1 MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWS 80
Cdd:cd17444   91 MFSTLRFFEGFCLAGIILSLYALRIELCPPGHRFMITMVASFIAMAGQFLMPGLAALCRDWQVLQAVIICPFLLMLSYWC 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025  81 IFPeslrwlmatqqfesakrlilhftqknrmnpegdikgvipelekelsrrpkkvcivkvvgtrnlwKNIVVLCVNSLTG 160
Cdd:cd17444  171 IFP----------------------------------------------------------------KNIVVLCVNSLTG 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025 161 YGIHHCFARSMMGHEVKVPLLENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLNLIGKYS 240
Cdd:cd17444  187 YGIHHCFAKSMMDHEMKGSFLHNFYAEYYTMAVIALASCLAMCPVVGFLGRRGGLLLFMILTALASLLQLGLLNLIGKYS 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025 241 QHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHH 320
Cdd:cd17444  267 QHPDSGMSDEVKDKFSVTFSIVGMFSSHAVGSLSVFFCAEITPTVIRGGGLGLVLASAGFGMLTAPIMELHNQKGYFLHH 346


                 ....
gi 557129025 321 IIFA 324
Cdd:cd17444  347 IIFA 350
MFS_SLC22A17_like cd17373
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ...
 1-324 1.92e-124

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340931 [Multi-domain]  Cd Length: 348  Bit Score: 363.38  E-value: 1.92e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025   1 MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWS 80
Cdd:cd17373   80 MFSTLRFLEGFCLAGIILTLYLLRLELCDPGKRLMITMVASLVAVAGQFLMPGLAALCRDWRVLQALIICPFLLMLLYWS 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025  81 IFPeslrwlmatqqfesakrlilhftqknrmnpegdikgvipelekelsrrpkkvcivkvvgtrnlwKNIVVLCVNSLTG 160
Cdd:cd17373  160 IFP----------------------------------------------------------------KNILILGFNSLTG 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025 161 YGIHHCFARSMMGHEVkvpllENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLNLIGKYS 240
Cdd:cd17373  176 YGIRHCFARSMMGHEP-----ENFYLDYYLTAGIAAVACVFLCVTVDFLGRRGGLLLFMILTGLASLLLLGLLNLIGKYS 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025 241 QHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHH 320
Cdd:cd17373  251 QHPDSGMSDSVKDKFSIAFSVLGLFASHAVGSLSVLFAAEVTPTVIRGGGLGLVLASGGLGMLTGPIIELHNQKGYFLQH 330


                 ....
gi 557129025 321 IIFA 324
Cdd:cd17373  331 VVFA 334
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
 1-324 4.41e-55

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 185.36  E-value: 4.41e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025   1 MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWS 80
Cdd:cd17443   91 TFLVLRLLQGGTLAGVFLSLYIARLELCDPSHRLMVSMGAGFFSVAGELLLPGLAVLCRDWRVLQGVGTLPLLLLLLYWC 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025  81 ifpeslrwlmatqqFESAKRLILHFTqknrmnpegdikgvipelekelsrrpkkvcivkvvgtrnlwknivvlcvnSLTG 160
Cdd:cd17443  171 --------------FPSRNGLILGFT--------------------------------------------------AFIG 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025 161 YGIHHCFARSMMghevkvPLLENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLgllnligkys 240
Cdd:cd17443  187 GGIRYCFARNLA------PFVPTFYLPYFLQAGLEALACIFLCLTVDRCGRRGVLLLGTIVTGLSSLLLL---------- 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025 241 qhpdsGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHH 320
Cdd:cd17443  251 -----ALTQYLHGGLVLVLSVVGLLASHAVSMLSMFFAAEVLPTVIRGAGLGLIMGAGFLGRAAGPLMELQNKQGYFLHH 325


                 ....
gi 557129025 321 IIFA 324
Cdd:cd17443  326 VVFA 329
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
 1-324 3.98e-49

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 169.57  E-value: 3.98e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025   1 MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYws 80
Cdd:cd17445   91 LFMAMRFLLGAALAGVYLTLYLTRLELCDPPQRLLVAMAGGLTMVGGHFLLLGLALGCGSWRVLQGTITAPLSLFLCY-- 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025  81 ifpeslrwlmatqqfesakrlilhftqknrmnpegDIKGVipelekelsrrpkkvcivkvvgtrnlwKNIVVLCVNSLTG 160
Cdd:cd17445  169 -----------------------------------GCPGV---------------------------KNLLILGFTTFIA 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025 161 YGIHHCFarSMMGHEVKvPLLENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLgllnligkys 240
Cdd:cd17445  187 HAISHCY--QSFSDDVR-GTPSTFYLSYLLSTGTAGLACLFLCATVDRFGRRGILLLAMTLTGIASLILL---------- 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025 241 qhpdsGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHH 320
Cdd:cd17445  254 -----GLMDYLNDAAIKTFSILGLFSSQAAASLSILFAAEVIPTVIRGSGLGLIMALGSLGGLSSPLMRLRNQHGYFLHH 328


                 ....
gi 557129025 321 IIFA 324
Cdd:cd17445  329 VVLA 332
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 1-347 3.06e-25

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 107.41  E-value: 3.06e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025    1 MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWS 80
Cdd:TIGR00898 182 VFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSW 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025   81 IFPESLRWLMATQQFESAKRLILHFTQKNRMNPEGDIKgvIPELEKELSRRPKKVCIVKVVGTRNL-WKNIVVLCV---N 156
Cdd:TIGR00898 262 FVPESPRWLISQGRIEEALKILQRIAKINGKKLPAEVL--SLSLEKDLSSSKKQYSFLDLFRTPNLrKTTLCLMMLwftT 339

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025  157 SLTGYGIhhcfarsMMGHEVkvpLLENFYADYYTTASIALVSCLAMCVVVRFLGRR----------GGLLLFMILTALAS 226
Cdd:TIGR00898 340 AFSYYGL-------VLDLGN---LGGNIYLDLFISGLVELPAKLITLLLIDRLGRRytmaaslllaGVALLLLLFVPVDL 409

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025  227 LLQLGLLNLIGKYSqhpdsgmsdsvkdkFSIAFSIVGMFAshavgslsvffcAEITPTVIRCGGLGLVLASAGFGMLTAP 306
Cdd:TIGR00898 410 YFLRTALAVLGKFG--------------ITSAFQMVYLYT------------AELYPTVVRNLGVGVCSTMARVGSIISP 463

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 557129025  307 IIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPE 347
Cdd:TIGR00898 464 FLVYLGEKWLFLPLVLFGGLALLAGILTLFLPETKGVPLPE 504
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 1-324 1.36e-20

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 91.87  E-value: 1.36e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025   1 MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWs 80
Cdd:cd17317   80 LFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLL- 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025  81 ifpeslrWLMatqqfesakrlilhftqknrmnpegdikgvipelekelsrrPKKVCIVkvvgtrnlwknIVVLCVNSLTG 160
Cdd:cd17317  159 -------WWL-----------------------------------------PRRTIIV-----------GLIWFVTSLVY 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025 161 YGIhhcfarSMMGHEvkvpLLENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLqlgllnlIGKYS 240
Cdd:cd17317  180 YGL------SLNSSN----LGGNLYLNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSLLLAGLACLV-------TALLP 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025 241 QHPDSgmsdsvkdkFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHH 320
Cdd:cd17317  243 DDENT---------LALTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVLLGKIGPLLPL 313


                 ....
gi 557129025 321 IIFA 324
Cdd:cd17317  314 IIFG 317
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 1-83 5.70e-10

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 60.12  E-value: 5.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025   1 MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWS 80
Cdd:cd17446   88 IYCVFRFLTGMALSGIVLNSVSLNVEWMPTRVRAVVGTLLGYCYTLGQLILAGVAYAIRDWRWLQLAVSLPFFIFFLYSW 167


                 ...
gi 557129025  81 IFP 83
Cdd:cd17446  168 WFP 170
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 5-323 1.33e-09

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 59.23  E-value: 1.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025   5 LRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYwsifpe 84
Cdd:cd17374   94 LRFLAGFAVSGISINTLILGTEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIRDWRLLQLVVSVPFFLFFLY------ 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025  85 sLRWLmatqqfesakrlilhftqknrmnpegdikgvipelekelsrrPKKVCIvkvvgtrnlwkNIVVLCVNSLTGYGIh 164
Cdd:cd17374  168 -SWWL------------------------------------------PKRTLI-----------LSFVWFANSFSYYGL- 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025 165 hcfarsMMGhevkvplLENFYAD-YYTTASIALVSCLAMCV---VVRFLGRRGGLLLFMILTAlaslLQLGLLNLIGKYS 240
Cdd:cd17374  193 ------SLD-------LQHLGLNvFLLQFLFGAVEVPARCLalfLLNHMGRRISQAVLLLLAG----LCILANIFVPQEM 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025 241 QHpdsgmsdsvkdkFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHH 320
Cdd:cd17374  256 QT------------LRTVLAVLGKGSSAAAFTISYVYTAELFPTVLRQTGMGLNSMFARIGGILAPLIMLLGVYSPLLPM 323


                 ...
gi 557129025 321 IIF 323
Cdd:cd17374  324 IIY 326
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
 2-324 4.21e-07

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 51.59  E-value: 4.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025   2 FSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALC-RDWQVLQALIICPFLLMLLYWS 80
Cdd:cd17378   90 YAFLRFLTGFGRSGIGTCALVLATEPVGPKWRGQVGMSTFFFFVLGFMSLPGIAYLNgSSWRVLYFWTSIPALIYCILVY 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025  81 IFPeslrwlmatqqfesaKRLIlhftqknrmnpegdikgvipelekelsrrpkkvcIVKVVGtrnlwknivvlCVNSLTG 160
Cdd:cd17378  170 LFA---------------RRLL----------------------------------AVMVIG-----------FGIGMVY 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025 161 YGIhhcfarSMMGHEVKVplleNFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGllnligkys 240
Cdd:cd17378  190 YGI------PLAVGNLKF----NIYLSVALNALSELPAFVITAFLLDRFGRRPSLLGFTLLSGASCLLCFV--------- 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025 241 qhpdsgMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHH 320
Cdd:cd17378  251 ------LSIGGTTSLQIALELVGFFGAAGAFNLLYIYTVELFPTCVRNAALGMLRQALVVGGIFAPFIVSLGRKNAALSF 324


                 ....
gi 557129025 321 IIFA 324
Cdd:cd17378  325 GVFG 328
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 1-83 3.67e-05

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 45.49  E-value: 3.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025   1 MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWS 80
Cdd:cd17447   90 MFAITRTLTGFALTGFSIISMVLCVEWVDIEHRTVAGVLISLFWTVGNMLLALVAYLIRDWRWLILAVTLPCAPGIITWW 169


                 ...
gi 557129025  81 IFP 83
Cdd:cd17447  170 WVP 172
Sugar_tr pfam00083
Sugar (and other) transporter;
6-324 4.44e-05

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 45.34  E-value: 4.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025    6 RFFEGFCLAGIILTLYALRIELCPPGKR-FMITMVASFVAMaGQFLMPGLA---ALCRD---WQVLQALIICPFLLMLLY 78
Cdd:pfam00083 109 RVLVGIGVGGASVLAPMYISEIAPKKLRgALGSLYQLAITF-GILLAYIFGlglNKTSNsdgWRIPLGLQLVPALLLIIG 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025   79 WSIFPESLRWLMATQQFESAKRLIlhftqKNRMNPEGDIKGVIPELEK-ELSRRPKKVCIVKVVGTRNLWKNIVVLCV-- 155
Cdd:pfam00083 188 LLFLPESPRWLVEKGRLEEAREVL-----AKLRGVPDVDRELDEIKDSlEAGQEAEKASWKELFSTKTRRQRLLIGVMlq 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025  156 --------NSLTGYGihhcfarSMMGHEVKVPllenfyADYYTTASIALVSCLAMCV---VVRFLGRRgGLLLFMILTAL 224
Cdd:pfam00083 263 ifqqltgiNAIFYYS-------TTIFENLGLS------DSFLVTIIVGVVNFVFTFIaifLVDRFGRR-PLLLLGAAGMA 328

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025  225 ASLLQLGLLNLIGKYSQHPDSGmsdsvkdkFSIAFsIVGMFASHAVGSLSVFF--CAEITPTVIRCGGLGLVLAS---AG 299
Cdd:pfam00083 329 ICFVILGIVALLGVSKSDWAGI--------VAIVF-IALFIAFFAMGWGPVPWviVSELFPLSVRSKAMALATAAnwlAN 399

                         330       340
                  ....*....|....*....|....*..
gi 557129025  300 F--GMLTAPIIELHNQKGYFlhhIIFA 324
Cdd:pfam00083 400 FliGFLFPIITDAIGLGYTF---FIFA 423
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 1-283 2.14e-04

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 43.40  E-value: 2.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025   1 MFSTLRFFEGFClAGIILTLYALRI-ELCPPGKR----FMITMVASFVAMAGQFL-MPGLAALCRDWQVLQALIICPFLL 74
Cdd:cd17357  107 LLIFGRFLVGIA-CGLSTGFVPMYLqEISPSELRgalgSLTQIGVTLGILLGQVFgLPSVLGTETLWPYLLFFPGIPALL 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025  75 MLLYWSIFPESLRWLMATQQFESAKRLILHFTQknrmNPEGDIKGVIPELEKELSR--RPKKVCIVKVVGTRNLWKNIVV 152
Cdd:cd17357  186 QLAALPFFPESPKFLLISKGDEEEAEKSLKFLR----GIEDDVDQELEEIKKESEQmgDQKQVSLMQLLRDPSLRLPLLL 261

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025 153 LCVNSLTGY--GIHHCFARSM-----MGHEVKVPLLENFYADYYTTASialvSCLAMcVVVRFLGRRGGLLLFMILTAla 225
Cdd:cd17357  262 VLVVSASQQfsGINAIFFYSTfifenAGFSPQLAEWANLGIGIVNVLS----TIVGP-FLIEKVGRRPLLLISLSVCA-- 334

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 557129025 226 sllQLGLLNLIGKYSQHPDSGMSdsvkdKFSIAFSIV-GMFASHAVGSLSVFFCAEITP 283
Cdd:cd17357  335 ---VALLLMSVFLFLSEQNSWMS-----YGCIVAIFLfIFFFAIGLGPIPWFIGAELFP 385
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 6-212 2.42e-04

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 42.99  E-value: 2.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025   6 RFFEGFClAGIILTLYALRI-ELCPPGKRFMITMV-ASFVAMA---GQFLmpGLAALC---RDWQVLQALIICPFLLMLL 77
Cdd:cd17432  113 RFLVGIN-AGISLNVVPMYLgESAPKNLRGAVGLVpAIFITLGillGQVL--GLRELLgneEGWPLLLALTGVPALLQLL 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025  78 YWSIFPESLRWLMATQQFESAKRLILHftqknRMNPEGDIKGVIPELEKE----LSRRPKKVCivKVVGTRNL-WKNIVV 152
Cdd:cd17432  190 TLPFFPESPRYLLIEKGDEEAARKALQ-----RLRGKEDVDDEMEEMLEEqraeKGVGTVSVL--ELFRDRSVrWQLISI 262

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 557129025 153 LCVNSltgyGIHHCFARSMmghevkvplleNFYADY-------------YTTA---SIALVSCLAMCVVVRFLGRR 212
Cdd:cd17432  263 IVLMA----GQQLCGINAI-----------YFYADSifleagipedkiqYVTVgtgACEVLATITCVLVIERLGRR 323
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 5-90 1.25e-03

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 40.41  E-value: 1.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025   5 LRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPE 84
Cdd:cd17379   92 FRFLQGLFGKGGWMTGYVLVTEFVGSKYRRTVGIVYQMFFTLGLLILPGIAYFIPHWRWLQLAVTLPNFLFLLYYWFIPK 171


                 ....*.
gi 557129025  85 SLRWLM 90
Cdd:cd17379  172 HTFILM 177
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 2-89 5.09e-03

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 38.88  E-value: 5.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557129025    2 FSTLRFFEGFCLAGIILTLYALRIELCPPGKR--FMITMVASFV--AMAGQFLMPGLAALcRDWQVLQAL-IICPFLLML 76
Cdd:TIGR00895 108 LLILRFLAGLGLGGLMPNLNALVSEYAPKRFRgtAVGLMFCGYPigAAVGGFLAGWLIPV-FGWRSLFYVgGIAPLLLLL 186

                          90
                  ....*....|...
gi 557129025   77 LYWSIFPESLRWL 89
Cdd:TIGR00895 187 LLMRFLPESIDFL 199
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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