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Conserved domains on  [gi|556503382|ref|NP_001273271|]
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protein chibby homolog 2 isoform 3 [Homo sapiens]

Protein Classification

Cby_like and SMC_prok_B domain-containing protein( domain architecture ID 10164867)

Cby_like and SMC_prok_B domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cby_like cd07429
Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins; ...
 41-156 2.96e-33

Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins; Chibby(Cby) is a well-conserved nuclear protein that functions as part of the Wnt/beta-catenin signaling pathway. Specifically, Cby binds directly to beta-catenin by interacting with its central region, which harbors armadillo repeats. Cby-beta-catenin interactions may also involve 14-3-3 proteins. By competing with other binding partners of beta-catenin, the Tcf/Lef transcription factors, Cby inhibits transcriptional activation. Cby has been shown to play a role in adipocyte differentiation. The C-terminal region of Cby appears to contain an alpha-helical coiled-coil motif.


:

Pssm-ID: 143631  Cd Length: 108  Bit Score: 120.52  E-value: 2.96e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556503382  41 LPRLSRRMASQHSYPLNRFSSVPLDPMERPMSQADLELDYNPPRVQLSDEMFVFQDGRWVNENCRlqspyfSPSASFHHK 120
Cdd:cd07429    1 MPLFGRKFSPKKTPPRKSASLSNLRLLDRSTRQAELGLDYGPIRLKLGGQELVFEDGRWISESGG------SSGVSGREV 74

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 556503382 121 LHHKRlaKECMLQEENKSLREENKALREENRMLSKE 156
Cdd:cd07429   75 LRLKK--KNQQLEEENNLLKLKIEVLLDMLAETTAE 108
 
Name Accession Description Interval E-value
Cby_like cd07429
Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins; ...
 41-156 2.96e-33

Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins; Chibby(Cby) is a well-conserved nuclear protein that functions as part of the Wnt/beta-catenin signaling pathway. Specifically, Cby binds directly to beta-catenin by interacting with its central region, which harbors armadillo repeats. Cby-beta-catenin interactions may also involve 14-3-3 proteins. By competing with other binding partners of beta-catenin, the Tcf/Lef transcription factors, Cby inhibits transcriptional activation. Cby has been shown to play a role in adipocyte differentiation. The C-terminal region of Cby appears to contain an alpha-helical coiled-coil motif.


Pssm-ID: 143631  Cd Length: 108  Bit Score: 120.52  E-value: 2.96e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556503382  41 LPRLSRRMASQHSYPLNRFSSVPLDPMERPMSQADLELDYNPPRVQLSDEMFVFQDGRWVNENCRlqspyfSPSASFHHK 120
Cdd:cd07429    1 MPLFGRKFSPKKTPPRKSASLSNLRLLDRSTRQAELGLDYGPIRLKLGGQELVFEDGRWISESGG------SSGVSGREV 74

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 556503382 121 LHHKRlaKECMLQEENKSLREENKALREENRMLSKE 156
Cdd:cd07429   75 LRLKK--KNQQLEEENNLLKLKIEVLLDMLAETTAE 108
Chibby pfam14645
Chibby family; This family includes the eukaryotic chibby proteins. These proteins inhibit the ...
 42-153 2.63e-10

Chibby family; This family includes the eukaryotic chibby proteins. These proteins inhibit the wingless/Wnt pathway by binding to beta-catenin and inhibiting beta-catenin-mediated transcriptional activation. Chibby is Japanese for small, and is named after the RNAi phenotype seen in Drosophila.


Pssm-ID: 464233  Cd Length: 113  Bit Score: 57.32  E-value: 2.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556503382   42 PRLSRRMASQhSYPLNRFSSVP-LDPMERPMSQADLELDYNPPRVQLSDEMFVFQDGRWVNEncrlqspyfSPSASFHHK 120
Cdd:pfam14645   1 PLFSNKFSPK-KIPLRKSSSLSnLYLLDPSTREAELGLDYGPIKLRLGGQELVFEDGQWVSE---------SGGAGGTGK 70

                          90       100       110
                  ....*....|....*....|....*....|...
gi 556503382  121 lhhkrlakecmlqeENKSLREENKALREENRML 153
Cdd:pfam14645  71 --------------EMQRLKKRNQQLEEENNLL 89
 
Name Accession Description Interval E-value
Cby_like cd07429
Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins; ...
 41-156 2.96e-33

Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins; Chibby(Cby) is a well-conserved nuclear protein that functions as part of the Wnt/beta-catenin signaling pathway. Specifically, Cby binds directly to beta-catenin by interacting with its central region, which harbors armadillo repeats. Cby-beta-catenin interactions may also involve 14-3-3 proteins. By competing with other binding partners of beta-catenin, the Tcf/Lef transcription factors, Cby inhibits transcriptional activation. Cby has been shown to play a role in adipocyte differentiation. The C-terminal region of Cby appears to contain an alpha-helical coiled-coil motif.


Pssm-ID: 143631  Cd Length: 108  Bit Score: 120.52  E-value: 2.96e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556503382  41 LPRLSRRMASQHSYPLNRFSSVPLDPMERPMSQADLELDYNPPRVQLSDEMFVFQDGRWVNENCRlqspyfSPSASFHHK 120
Cdd:cd07429    1 MPLFGRKFSPKKTPPRKSASLSNLRLLDRSTRQAELGLDYGPIRLKLGGQELVFEDGRWISESGG------SSGVSGREV 74

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 556503382 121 LHHKRlaKECMLQEENKSLREENKALREENRMLSKE 156
Cdd:cd07429   75 LRLKK--KNQQLEEENNLLKLKIEVLLDMLAETTAE 108
Chibby pfam14645
Chibby family; This family includes the eukaryotic chibby proteins. These proteins inhibit the ...
 42-153 2.63e-10

Chibby family; This family includes the eukaryotic chibby proteins. These proteins inhibit the wingless/Wnt pathway by binding to beta-catenin and inhibiting beta-catenin-mediated transcriptional activation. Chibby is Japanese for small, and is named after the RNAi phenotype seen in Drosophila.


Pssm-ID: 464233  Cd Length: 113  Bit Score: 57.32  E-value: 2.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556503382   42 PRLSRRMASQhSYPLNRFSSVP-LDPMERPMSQADLELDYNPPRVQLSDEMFVFQDGRWVNEncrlqspyfSPSASFHHK 120
Cdd:pfam14645   1 PLFSNKFSPK-KIPLRKSSSLSnLYLLDPSTREAELGLDYGPIKLRLGGQELVFEDGQWVSE---------SGGAGGTGK 70

                          90       100       110
                  ....*....|....*....|....*....|...
gi 556503382  121 lhhkrlakecmlqeENKSLREENKALREENRML 153
Cdd:pfam14645  71 --------------EMQRLKKRNQQLEEENNLL 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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