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Conserved domains on  [gi|552953861|ref|NP_001272845|]
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geminin coiled-coil domain-containing protein 1 isoform 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GemC1_CC cd22588
central coiled-coil domain of geminin coiled-coil domain-containing protein 1; Geminin ...
 73-133 1.56e-38

central coiled-coil domain of geminin coiled-coil domain-containing protein 1; Geminin coiled-coil domain-containing protein 1 (GemC1), which, together with McIdas (also called Idas or multicilin) and geminin, controls both the cell cycle and differentiation decisions in cells. GemC1 binds to geminin and is implicated in DNA replication control. It also functions as an early regulator of multiciliogenesis. GemC1 and Idas specify the multiciliate cell fate by forming complexes with the E2F4/5 transcription factors, resulting in centriole amplification and cilia formation. GemC1 belongs to the geminin family of proteins that also includes geminin and McIdas. They share a homologous central coiled-coil domain that mediates homo- and heterodimerization with other family members; this ability is likely to be important for modulating their function in cycling and differentiating cells. This model represents the central coiled-coil domain of GemC1.


:

Pssm-ID: 439142  Cd Length: 61  Bit Score: 131.13  E-value: 1.56e-38
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 552953861  73 CSWEEAQLSSQLYRNKQLQDTLLQKEEELARLHEENNHLRQYLNSTLVKRLEEKAKKLLSS 133
Cdd:cd22588    1 DSTWTDQLSPQLQRNKQLQDTLLQKEEELARLHEENNKLRQFLNSSFVKCLEEKAKKLLSQ 61
YhaN super family cl34808
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
28-180 1.77e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


The actual alignment was detected with superfamily member COG4717:

Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 46.30  E-value: 1.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552953861  28 ESGvdvsKETWVSFWAAGLLDntELQQAPQVLESPS----ELSFPVLDSCSWEEAQLSSQLYRNKQLQDTLLQKEEELAR 103
Cdd:COG4717   33 EAG----KSTLLAFIRAMLLE--RLEKEADELFKPQgrkpELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEE 106

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 552953861 104 LHEENNHLRQYLnstlvKRLEEKAKKLLSSDEFSKVFGKLRKEKRKPKEHRHSPAEIPQFKTAKRNLSTEFSNCEEQ 180
Cdd:COG4717  107 LEAELEELREEL-----EKLEKLLQLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEE 178
 
Name Accession Description Interval E-value
GemC1_CC cd22588
central coiled-coil domain of geminin coiled-coil domain-containing protein 1; Geminin ...
 73-133 1.56e-38

central coiled-coil domain of geminin coiled-coil domain-containing protein 1; Geminin coiled-coil domain-containing protein 1 (GemC1), which, together with McIdas (also called Idas or multicilin) and geminin, controls both the cell cycle and differentiation decisions in cells. GemC1 binds to geminin and is implicated in DNA replication control. It also functions as an early regulator of multiciliogenesis. GemC1 and Idas specify the multiciliate cell fate by forming complexes with the E2F4/5 transcription factors, resulting in centriole amplification and cilia formation. GemC1 belongs to the geminin family of proteins that also includes geminin and McIdas. They share a homologous central coiled-coil domain that mediates homo- and heterodimerization with other family members; this ability is likely to be important for modulating their function in cycling and differentiating cells. This model represents the central coiled-coil domain of GemC1.


Pssm-ID: 439142  Cd Length: 61  Bit Score: 131.13  E-value: 1.56e-38
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 552953861  73 CSWEEAQLSSQLYRNKQLQDTLLQKEEELARLHEENNHLRQYLNSTLVKRLEEKAKKLLSS 133
Cdd:cd22588    1 DSTWTDQLSPQLQRNKQLQDTLLQKEEELARLHEENNKLRQFLNSSFVKCLEEKAKKLLSQ 61
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
28-180 1.77e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 46.30  E-value: 1.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552953861  28 ESGvdvsKETWVSFWAAGLLDntELQQAPQVLESPS----ELSFPVLDSCSWEEAQLSSQLYRNKQLQDTLLQKEEELAR 103
Cdd:COG4717   33 EAG----KSTLLAFIRAMLLE--RLEKEADELFKPQgrkpELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEE 106

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 552953861 104 LHEENNHLRQYLnstlvKRLEEKAKKLLSSDEFSKVFGKLRKEKRKPKEHRHSPAEIPQFKTAKRNLSTEFSNCEEQ 180
Cdd:COG4717  107 LEAELEELREEL-----EKLEKLLQLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEE 178
YabA COG4467
Regulator of replication initiation timing YabA [Replication, recombination and repair];
77-130 9.77e-03

Regulator of replication initiation timing YabA [Replication, recombination and repair];


Pssm-ID: 443564 [Multi-domain]  Cd Length: 107  Bit Score: 35.23  E-value: 9.77e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 552953861  77 EAQLSsQLYRN-KQLQDTLLQKEEELARLHEENNHLRQYLNSTLVKRLEEKAKKL 130
Cdd:COG4467   14 EEQLG-ELLKElGELKDEVAELLEENARLRIENEHLRERLEELEKKKEKKAEKDI 67
 
Name Accession Description Interval E-value
GemC1_CC cd22588
central coiled-coil domain of geminin coiled-coil domain-containing protein 1; Geminin ...
 73-133 1.56e-38

central coiled-coil domain of geminin coiled-coil domain-containing protein 1; Geminin coiled-coil domain-containing protein 1 (GemC1), which, together with McIdas (also called Idas or multicilin) and geminin, controls both the cell cycle and differentiation decisions in cells. GemC1 binds to geminin and is implicated in DNA replication control. It also functions as an early regulator of multiciliogenesis. GemC1 and Idas specify the multiciliate cell fate by forming complexes with the E2F4/5 transcription factors, resulting in centriole amplification and cilia formation. GemC1 belongs to the geminin family of proteins that also includes geminin and McIdas. They share a homologous central coiled-coil domain that mediates homo- and heterodimerization with other family members; this ability is likely to be important for modulating their function in cycling and differentiating cells. This model represents the central coiled-coil domain of GemC1.


Pssm-ID: 439142  Cd Length: 61  Bit Score: 131.13  E-value: 1.56e-38
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 552953861  73 CSWEEAQLSSQLYRNKQLQDTLLQKEEELARLHEENNHLRQYLNSTLVKRLEEKAKKLLSS 133
Cdd:cd22588    1 DSTWTDQLSPQLQRNKQLQDTLLQKEEELARLHEENNKLRQFLNSSFVKCLEEKAKKLLSQ 61
geminin-like_CC cd21103
coiled-coil domain found in the geminin family; The geminin family includes geminin, geminin ...
 73-129 6.41e-21

coiled-coil domain found in the geminin family; The geminin family includes geminin, geminin coiled-coil domain-containing protein 1 (GemC1), and McIdas. Together, geminin, GemC1, and McIdas (also called Idas or multicilin), controls both the cell cycle and differentiation decisions in cells. They were initially identified as cell cycle regulators associated with the chromosome cycle. Geminin is required to ensure once-per-cell-cycle genome replication, while McIdas and GemC1 bind to geminin and are implicated in DNA replication control. Geminin binds to Cdt1, a key component and crucial regulator of pre-replicative complexes (pre-RC), in a timely manner to inhibit DNA replication. Geminin family members also function as early regulators of multiciliogenesis. GemC1 and McIdas specify the multiciliate cell fate by forming complexes with the E2F4/5 transcription factors, resulting in centriole amplification and cilia formation. Geminin family proteins contain a homologous central coiled-coil domain that mediates homo- and heterodimerization; this ability is likely to be important for modulating their function in cycling and differentiating cells. This model represents the central coiled-coil domain of the geminin family.


Pssm-ID: 439141  Cd Length: 58  Bit Score: 84.62  E-value: 6.41e-21
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 552953861  73 CSWEEAQLSSQLYRNKQLQDTLLQKEEELARLHEENNHLRQYLNSTLVKRLEEKAKK 129
Cdd:cd21103    1 ASWEEAALSSALYENKQLHDTLVQKEEEIARLKEENNHLREYANSALVKAEEEKALK 57
McIdas_CC cd22590
central coiled-coil domain of McIdas (or multicilin); McIdas (also called Idas or multicilin), ...
 87-113 7.51e-06

central coiled-coil domain of McIdas (or multicilin); McIdas (also called Idas or multicilin), together with geminin coiled-coil domain-containing protein 1 (GemC1) and geminin, controls both the cell cycle and differentiation decisions in cells. Idas binds to geminin and is implicated in DNA replication control. It also functions as an early regulator of multiciliogenesis. GemC1 and McIdas specify the multiciliate cell fate by forming complexes with the E2F4/5 transcription factors, resulting in centriole amplification and cilia formation. Idas belongs to the geminin family of proteins that also includes geminin and GemC1. They share a homologous central coiled-coil domain that mediates homo- and heterodimerization with other family members; this ability is likely to be important for modulating their function in cycling and differentiating cells. This model represents the central coiled-coil domain of McIdas.


Pssm-ID: 439144  Cd Length: 64  Bit Score: 42.86  E-value: 7.51e-06
                         10        20
                 ....*....|....*....|....*..
gi 552953861  87 NKQLQDTLLQKEEELARLHEENNHLRQ 113
Cdd:cd22590   19 NNQLHETLTRKQEEIDSLQERNVQLKE 45
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
28-180 1.77e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 46.30  E-value: 1.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552953861  28 ESGvdvsKETWVSFWAAGLLDntELQQAPQVLESPS----ELSFPVLDSCSWEEAQLSSQLYRNKQLQDTLLQKEEELAR 103
Cdd:COG4717   33 EAG----KSTLLAFIRAMLLE--RLEKEADELFKPQgrkpELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEE 106

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 552953861 104 LHEENNHLRQYLnstlvKRLEEKAKKLLSSDEFSKVFGKLRKEKRKPKEHRHSPAEIPQFKTAKRNLSTEFSNCEEQ 180
Cdd:COG4717  107 LEAELEELREEL-----EKLEKLLQLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEE 178
YabA COG4467
Regulator of replication initiation timing YabA [Replication, recombination and repair];
77-130 9.77e-03

Regulator of replication initiation timing YabA [Replication, recombination and repair];


Pssm-ID: 443564 [Multi-domain]  Cd Length: 107  Bit Score: 35.23  E-value: 9.77e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 552953861  77 EAQLSsQLYRN-KQLQDTLLQKEEELARLHEENNHLRQYLNSTLVKRLEEKAKKL 130
Cdd:COG4467   14 EEQLG-ELLKElGELKDEVAELLEENARLRIENEHLRERLEELEKKKEKKAEKDI 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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