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Conserved domains on  [gi|550822226|ref|NP_001272422|]
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guanine nucleotide-binding protein subunit beta-like protein 1 isoform 3 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
11-353 2.38e-25

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.76  E-value: 2.38e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822226  11 PRFVLRGTQSAVNTLHFCPPSQaagnpLLFSGSQNGLVHIWSLQTRRIVTTLNGHGGqGVIWLKTLPQGHQLLrvetCGC 90
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPDGK-----TLASGSADGTVRLWDLATGKLLRTLTGHSG-AVTSVAFSPDGKLLA----SGS 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822226  91 ACGTWRragtpswtqfswtVW-ASAGAPSWSgdssagcLLCQGRAATRISHHPVGRVRAqgVGSDEQpkgrdyaliqtlR 169
Cdd:COG2319  182 DDGTVR-------------LWdLATGKLLRT-------LTGHTGAVRSVAFSPDGKLLA--SGSADG------------T 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822226 170 VQILEMPSKTSVCTLKPEADArpgmPMCLGLwqtnSSLRPLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDF--D 247
Cdd:COG2319  228 VRLWDLATGKLLRTLTGHSGS----VRSVAF----SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspD 299

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822226 248 SQKAkgISGSAGKVLAVWSLDDQQSLQVKKTHeltNPGIAEVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAP 327
Cdd:COG2319  300 GKLL--ASGSDDGTVRLWDLATGKLLRTLTGH---TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGA 374

                        330       340
                 ....*....|....*....|....*..
gi 550822226 328 VYCVAFAADG-LLAAGSKDQRISIWSL 353
Cdd:COG2319  375 VTSVAFSPDGrTLASGSADGTVRLWDL 401
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
11-353 2.38e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.76  E-value: 2.38e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822226  11 PRFVLRGTQSAVNTLHFCPPSQaagnpLLFSGSQNGLVHIWSLQTRRIVTTLNGHGGqGVIWLKTLPQGHQLLrvetCGC 90
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPDGK-----TLASGSADGTVRLWDLATGKLLRTLTGHSG-AVTSVAFSPDGKLLA----SGS 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822226  91 ACGTWRragtpswtqfswtVW-ASAGAPSWSgdssagcLLCQGRAATRISHHPVGRVRAqgVGSDEQpkgrdyaliqtlR 169
Cdd:COG2319  182 DDGTVR-------------LWdLATGKLLRT-------LTGHTGAVRSVAFSPDGKLLA--SGSADG------------T 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822226 170 VQILEMPSKTSVCTLKPEADArpgmPMCLGLwqtnSSLRPLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDF--D 247
Cdd:COG2319  228 VRLWDLATGKLLRTLTGHSGS----VRSVAF----SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspD 299

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822226 248 SQKAkgISGSAGKVLAVWSLDDQQSLQVKKTHeltNPGIAEVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAP 327
Cdd:COG2319  300 GKLL--ASGSDDGTVRLWDLATGKLLRTLTGH---TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGA 374

                        330       340
                 ....*....|....*....|....*..
gi 550822226 328 VYCVAFAADG-LLAAGSKDQRISIWSL 353
Cdd:COG2319  375 VTSVAFSPDGrTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-352 1.40e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 101.26  E-value: 1.40e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822226  11 PRFVLRGTQSAVNTLHFCPPSqaagnPLLFSGSQNGLVHIWSLQTRRIVTTLNGHGGqGVIWLKTLPQGHQLLrveTCGC 90
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDG-----KLLATGSGDGTIKVWDLETGELLRTLKGHTG-PVRDVAASADGTYLA---SGSS 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822226  91 AcGTWRragtpswtqfswtVWasagapSWSGDSSAGCLLCQGRAATRISHHPVGRVRAqGVGSDeqpkgrdyaliQTLRv 170
Cdd:cd00200   72 D-KTIR-------------LW------DLETGECVRTLTGHTSYVSSVAFSPDGRILS-SSSRD-----------KTIK- 118

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822226 171 qILEMPSKTSVCTLKPEADArpgmPMCLGLWQTNSslrpLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQK 250
Cdd:cd00200  119 -VWDVETGKCLTTLRGHTDW----VNSVAFSPDGT----FVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDG 189

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822226 251 AKGISGSAGKVLAVWSLDDQQSLQVKKTHEltnPGIAEVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYC 330
Cdd:cd00200  190 EKLLSSSSDGTIKLWDLSTGKCLGTLRGHE---NGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTS 266

                        330       340
                 ....*....|....*....|...
gi 550822226 331 VAFAADG-LLAAGSKDQRISIWS 352
Cdd:cd00200  267 LAWSPDGkRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 204-353 1.17e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.55  E-value: 1.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822226 204 NSSLRPLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGI-SGSAGKVLAVWSLDDQQSLQVKKthelT 282
Cdd:PLN00181 541 NSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGTIK----T 616

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 550822226 283 NPGIAEVTIRPDH-KILATAGWDHRIRVFHWRTMK-PLAVLAFHSAPVYCVAFAADGLLAAGSKDQRISIWSL 353
Cdd:PLN00181 617 KANICCVQFPSESgRSLAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 314-352 5.95e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 5.95e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 550822226   314 TMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWS 352
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
315-352 2.93e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 2.93e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 550822226  315 MKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWS 352
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGkLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
11-353 2.38e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.76  E-value: 2.38e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822226  11 PRFVLRGTQSAVNTLHFCPPSQaagnpLLFSGSQNGLVHIWSLQTRRIVTTLNGHGGqGVIWLKTLPQGHQLLrvetCGC 90
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPDGK-----TLASGSADGTVRLWDLATGKLLRTLTGHSG-AVTSVAFSPDGKLLA----SGS 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822226  91 ACGTWRragtpswtqfswtVW-ASAGAPSWSgdssagcLLCQGRAATRISHHPVGRVRAqgVGSDEQpkgrdyaliqtlR 169
Cdd:COG2319  182 DDGTVR-------------LWdLATGKLLRT-------LTGHTGAVRSVAFSPDGKLLA--SGSADG------------T 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822226 170 VQILEMPSKTSVCTLKPEADArpgmPMCLGLwqtnSSLRPLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDF--D 247
Cdd:COG2319  228 VRLWDLATGKLLRTLTGHSGS----VRSVAF----SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspD 299

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822226 248 SQKAkgISGSAGKVLAVWSLDDQQSLQVKKTHeltNPGIAEVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAP 327
Cdd:COG2319  300 GKLL--ASGSDDGTVRLWDLATGKLLRTLTGH---TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGA 374

                        330       340
                 ....*....|....*....|....*..
gi 550822226 328 VYCVAFAADG-LLAAGSKDQRISIWSL 353
Cdd:COG2319  375 VTSVAFSPDGrTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-352 1.40e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 101.26  E-value: 1.40e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822226  11 PRFVLRGTQSAVNTLHFCPPSqaagnPLLFSGSQNGLVHIWSLQTRRIVTTLNGHGGqGVIWLKTLPQGHQLLrveTCGC 90
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDG-----KLLATGSGDGTIKVWDLETGELLRTLKGHTG-PVRDVAASADGTYLA---SGSS 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822226  91 AcGTWRragtpswtqfswtVWasagapSWSGDSSAGCLLCQGRAATRISHHPVGRVRAqGVGSDeqpkgrdyaliQTLRv 170
Cdd:cd00200   72 D-KTIR-------------LW------DLETGECVRTLTGHTSYVSSVAFSPDGRILS-SSSRD-----------KTIK- 118

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822226 171 qILEMPSKTSVCTLKPEADArpgmPMCLGLWQTNSslrpLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQK 250
Cdd:cd00200  119 -VWDVETGKCLTTLRGHTDW----VNSVAFSPDGT----FVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDG 189

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822226 251 AKGISGSAGKVLAVWSLDDQQSLQVKKTHEltnPGIAEVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYC 330
Cdd:cd00200  190 EKLLSSSSDGTIKLWDLSTGKCLGTLRGHE---NGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTS 266

                        330       340
                 ....*....|....*....|...
gi 550822226 331 VAFAADG-LLAAGSKDQRISIWS 352
Cdd:cd00200  267 LAWSPDGkRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
97-353 2.77e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.68  E-value: 2.77e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822226  97 RAGTPSWTQFSWTVWASAGAPSWSGDSSAGCLLCQGRAATRISHHPVGRVRAQGVGSDEQPKGRDYALIQTLRVQILEMP 176
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822226 177 SKTSVCTLKPEADARPGMPMCLGLWQTNSSLRP--------------------LLLAGYEDGSVTLWDISERKVCSQITC 236
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLrtltghtgavrsvafspdgkTLASGSADGTVRLWDLATGKLLRTLTG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822226 237 HEEPVMGLDFDSQKAKGISGSAGKVLAVWSLDDQQSLQVKKTHeltNPGIAEVTIRPDHKILATAGWDHRIRVFHWRTMK 316
Cdd:COG2319  161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH---TGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK 237

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 550822226 317 PLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWSL 353
Cdd:COG2319  238 LLRTLTGHSGSVRSVAFSPDGrLLASGSADGTVRLWDL 275
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 205-353 2.36e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.40  E-value: 2.36e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822226 205 SSLRPLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGISGSAGKVLAVWSLDDQQSLQVKKTHEltnP 284
Cdd:cd00200   18 SPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHT---S 94

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822226 285 GIAEVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWSL 353
Cdd:cd00200   95 YVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtFVASSSQDGTIKLWDL 164
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 233-353 8.59e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.69  E-value: 8.59e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822226 233 QITCHEEPVMGLDFDSQKAKGISGSAGKVLAVWSLDDQQSLQVKKTHELtnpGIAEVTIRPDHKILATAGWDHRIRVFHW 312
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG---PVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 550822226 313 RTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWSL 353
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGrILSSSSRDKTIKVWDV 122
WD40 COG2319
WD40 repeat [General function prediction only];
14-314 1.37e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.18  E-value: 1.37e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822226  14 VLRGTQSAVNTLHFCPPSQaagnpLLFSGSQNGLVHIWSLQTRRIVTTLNGHGGqGVIWLKTLPQGHQLLrvetCGCACG 93
Cdd:COG2319  157 TLTGHSGAVTSVAFSPDGK-----LLASGSDDGTVRLWDLATGKLLRTLTGHTG-AVRSVAFSPDGKLLA----SGSADG 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822226  94 T---WRRAGTP---SWTQFSWTVWASAgapsWSGDSSagcllcqgRAATrishhpvgrvraqgvGSDEQpkgrdyaliqt 167
Cdd:COG2319  227 TvrlWDLATGKllrTLTGHSGSVRSVA----FSPDGR--------LLAS---------------GSADG----------- 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822226 168 lRVQILEMPSKTSVCTLKPEADARPGMpmclglwqtnsSLRP---LLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGL 244
Cdd:COG2319  269 -TVRLWDLATGELLRTLTGHSGGVNSV-----------AFSPdgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822226 245 DFDSQKAKGISGSAGKVLAVWSLDDQQSLQVKKTHEltnPGIAEVTIRPDHKILATAGWDHRIRVFHWRT 314
Cdd:COG2319  337 AFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHT---GAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 204-353 1.17e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.55  E-value: 1.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822226 204 NSSLRPLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGI-SGSAGKVLAVWSLDDQQSLQVKKthelT 282
Cdd:PLN00181 541 NSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGTIK----T 616

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 550822226 283 NPGIAEVTIRPDH-KILATAGWDHRIRVFHWRTMK-PLAVLAFHSAPVYCVAFAADGLLAAGSKDQRISIWSL 353
Cdd:PLN00181 617 KANICCVQFPSESgRSLAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 314-352 5.95e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 5.95e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 550822226   314 TMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWS 352
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
315-352 2.93e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 2.93e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 550822226  315 MKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWS 352
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGkLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 324-356 2.53e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.24  E-value: 2.53e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 550822226 324 HSAPVYCVAFAADG-LLAAGSKDQRISIWSLYPC 356
Cdd:cd00200    8 HTGGVTCVAFSPDGkLLATGSGDGTIKVWDLETG 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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