BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543173144  38 WQGLYPTIRERNAMMFNNDLMADVHFVVGPPGGTQRLPGHKYVLAVGSSVFHAMFYGELAEDKDEIRIPDVEPAAFLAML 117
Cdd:cd18348    1 WQGLYPTIRERNAVMFNNDLMADIHFVVGPPGGTQRLPGHKYVLAVGSSVFHAMFYGELAEDKDEIRIPDVEPAAFLAML 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 543173144 118 KYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLL 168
Cdd:cd18348   81 KYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLL 131

PHR domain; This domain is called PHR as it was original found in the proteins PAM, highwire and RPM. This domain can be duplicated in the highwire, PFAM and PRM sequence. The C-terminal region of the protein BTBD1 includes the PHR domain and is known to interact with Topoisomerase I, an enzyme which relaxes DNA supercoils.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543173144  315 HRFQSCAYRsnqWRYRGRC-DSIQFAVDKRVFIAGFGLYGSSCGSAEYSAKIELK------RQGVVLGQNLSKYFSDGSS 387
Cdd:pfam08005   1 NRFQSTGGG---WGYSGGSpDAIRFSVDRDIFLVGFGLYGSIGGPADYSVKIELIdgerweSLGEVLGENDTTFSSDGSN 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 543173144  388 NTFPVWFEYPVQIEPDTFYTASVILDGNElSYFGQEGMTEVQC-GKVTVQFQCSSDSTNGTGVQGGQIPELIFY 460
Cdd:pfam08005  78 DIFRVLFDEPVEIEPNVKYTASAKIKGPS-SYYGTNGLREVTCdGGVTFQFSSSSLSNNGTSVNRGQIPELLYY 150

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543173144  38 WQGLYPTIRERNAMMFNNDLMADVHFVVGPPGGTQRLPGHKYVLAVGSSVFHAMFYGELAEDKDEIRIPDVEPAAFLAML 117
Cdd:cd18348    1 WQGLYPTIRERNAVMFNNDLMADIHFVVGPPGGTQRLPGHKYVLAVGSSVFHAMFYGELAEDKDEIRIPDVEPAAFLAML 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 543173144 118 KYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLL 168
Cdd:cd18348   81 KYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLL 131

PHR domain; This domain is called PHR as it was original found in the proteins PAM, highwire and RPM. This domain can be duplicated in the highwire, PFAM and PRM sequence. The C-terminal region of the protein BTBD1 includes the PHR domain and is known to interact with Topoisomerase I, an enzyme which relaxes DNA supercoils.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543173144  315 HRFQSCAYRsnqWRYRGRC-DSIQFAVDKRVFIAGFGLYGSSCGSAEYSAKIELK------RQGVVLGQNLSKYFSDGSS 387
Cdd:pfam08005   1 NRFQSTGGG---WGYSGGSpDAIRFSVDRDIFLVGFGLYGSIGGPADYSVKIELIdgerweSLGEVLGENDTTFSSDGSN 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 543173144  388 NTFPVWFEYPVQIEPDTFYTASVILDGNElSYFGQEGMTEVQC-GKVTVQFQCSSDSTNGTGVQGGQIPELIFY 460
Cdd:pfam08005  78 DIFRVLFDEPVEIEPNVKYTASAKIKGPS-SYYGTNGLREVTCdGGVTFQFSSSSLSNNGTSVNRGQIPELLYY 150

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543173144    60 DVHFVVGppggTQRLPGHKYVLAVGSSVFHAMFYGELAED-KDEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYA 138
Cdd:smart00225   1 DVTLVVG----GKKFHAHKAVLAAHSPYFKALFSSDFKESdKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLEL 76

                           90       100
                   ....*....|....*....|.
gi 543173144   139 AKKYIVPHLARACVNFLETSL 159
Cdd:smart00225  77 ADYLQIPGLVELCEEFLLKLL 97

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543173144  177 PDLTQRCWEVIDAQAELALKSEGFCDIDFQTLESILRRETLN-AKEIVVFEAALNWAevecqRQDLalsiENKRKVLGKA 255
Cdd:pfam07707  14 TELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNvPSEEEVFEAVIRWV-----KHDV----ERRKKHLPEL 84

                          90
                  ....*....|....*.
gi 543173144  256 LYLIRIPTMALDDFAN 271
Cdd:pfam07707  85 LSAVRLPLLSPQYLLN 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543173144  38 WQGLYPTIRERNAMMFNNDLMADVHFVVGPPGGTQRLPGHKYVLAVGSSVFHAMFYGELAEDKDEIRIPDVEPAAFLAML 117
Cdd:cd18348    1 WQGLYPTIRERNAVMFNNDLMADIHFVVGPPGGTQRLPGHKYVLAVGSSVFHAMFYGELAEDKDEIRIPDVEPAAFLAML 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 543173144 118 KYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLL 168
Cdd:cd18348   81 KYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLL 131

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543173144  51 MMFNNDLMADVHFVVGPPGGTQRLPGHKYVLAVGSSVFHAMFYGELAEDKDEIRIPDVEPAAFLAMLKYIYCDEIDLAAD 130
Cdd:cd18349    1 LMFNNELMADVHFIVGPPGASQRVPAHKYVLAVGSSVFYAMFYGDLAEVKSEIHIPDVEPAAFLILLKYMYSDEIDLEAD 80

                         90       100
                 ....*....|....*....|....*....
gi 543173144 131 TVLATLYAAKKYIVPHLARACVNFLETSL 159
Cdd:cd18349   81 TVLATLYAAKKYIVPALAKACVNFLETSL 109

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This subfamily includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionarily-conserved role during neuronal development.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543173144 159 LSAKNACVLLSQSCLFEEPDLTQRCWEVIDAQAELALKSEGFCDIDFQTLESILRRETLNAKEIVVFEAALNWAEVECQR 238
Cdd:cd18488    1 LSARNACVLLSQSRLFEEPELMQRCWEVIDAQAELALKSEGFTEIDYKTLESILRRETLNAKESVVFEAALRWAEAECQR 80

                         90
                 ....*....|....*
gi 543173144 239 QDLALSIENKRKVLG 253
Cdd:cd18488   81 RGLEPTPENKRKVLG 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543173144  37 NWQGLYPTIRERNAMMFNNDLMADVHFVVGPPGGTQRLPGHKYVLAVGSSVFHAMFYGELAEDKDEIRIPDVEPAAFLAM 116
Cdd:cd18281    1 NWQASKTTVKERFAFLFNNETLSDVHFIVGKGDNEQRIPAHKFVLSIGSAVFDAMFNGGMATTSAEIELPDVEPAAFLAL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 543173144 117 LKYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVNFLETSLSAKN 163
Cdd:cd18281   81 LRFLYSDEVQIGPETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543173144  37 NWQGLYPTIRERNAMMFNNDLMADVHFVVG------PPGGTQRLPGHKYVLAVGSSVFHAMFYGELAEDKDEIRIPDVEP 110
Cdd:cd18346    1 NWQATKSSLKERFAFLFNNELLSDVRFVVGkgrprgPGPGAQRIPAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEP 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 543173144 111 AAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVNFLETSLSAKN 163
Cdd:cd18346   81 AAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADN 133

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This subfamily includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543173144 159 LSAKNACVLLSQSCLFEEPDLTQRCWEVIDAQAELALKSEGFCDIDFQTLESILRRETLNAKEIVVFEAALNWAEVECQR 238
Cdd:cd18487    1 LSSDNAFMLLTQARLFDEPQLASLCLETIDKNTAEALAAEGFTDIDLDTLCVVLERDTLGIRECKLFQAVLRWAEAECQR 80

                         90
                 ....*....|....*
gi 543173144 239 QDLALSIENKRKVLG 253
Cdd:cd18487   81 QGLSVTPENQRKVLG 95

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein specifically expressed in skeletal muscle. It interacts with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. It may serve as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543173144 159 LSAKNACVLLSQSCLFEEPDLTQRCWEVIDAQAELALKSEGFCDIDFQTLESILRRETLNAKEIVVFEAALNWAEVECQR 238
Cdd:cd18522    1 LRADNAFMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDLDTLCAVLERDTLSIRESRLFGAVVRWAEAECQR 80

                         90       100
                 ....*....|....*....|....*.
gi 543173144 239 QDLALSIENKRKVLGKALYLIRIPTM 264
Cdd:cd18522   81 QQLPVTSENKQKVLGKALSLIRFPLM 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543173144  58 MADVHFVVGppggTQRLPGHKYVLAVGSSVFHAMFYGELAEDK-DEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATL 136
Cdd:cd18186    1 LCDVTLVVG----GREFPAHRAVLAARSPYFRAMFSSGMKESSsSEIELDDVSPEAFEALLDYIYTGELELSEENVEELL 76

                 ....*.
gi 543173144 137 YAAKKY 142
Cdd:cd18186   77 AAADKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543173144  52 MFNNDLMADVHFVVGPPGgtQRLPGHKYVLAVGSSVFHAMFYGELAEDKDEIRIP--DVEPAAFLAMLKYIYCDEIDLAA 129
Cdd:cd18294    8 LINNPEFSDVKFLVGPER--QEIFAHKCILAARCEVFRAMFLTGPQKESTQSPLVlsDIEPEVFRAVLEFIYTNCVTLSN 85

                         90       100
                 ....*....|....*....|....*.
gi 543173144 130 DTVLATLYAAKKYIVPHLARACVNFL 155
Cdd:cd18294   86 HTVIEVLAAAVEYGLDELRKLCERFI 111

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543173144  51 MMFNNDLMADVHFVVgpPGGTqrLPGHKYVLAVGSSVFHAMFYGELAEDK-DEIRIPDVEPAAFLAMLKYIYCDEI-DLA 128
Cdd:cd18300    2 LFLNKGLFSDVTFIV--EDGT--IPAHKALLVARCDVMAAMFGGNFRESSaKEVELPGVSKETFLALLEYLYTDQApILE 77

                         90       100
                 ....*....|....*....|...
gi 543173144 129 ADTVLATLYAAKKYIVPHLARAC 151
Cdd:cd18300   78 DGDCVGLIVLANRLCLPRLVALC 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543173144  52 MFNNDLMADVHFVVGppggTQRLPGHKYVLAVGSSVFHAMFYGELAEDKD-EIRIPDVEPAAFLAMLKYIYCDEIDLAAD 130
Cdd:cd18237   15 MRKQKTLCDVILIVE----GREIKAHRVVLAAASHFFHLMFTSNMTESKSsEVELKDAEPDIIELLVEFAYTARISVNSN 90

                         90       100       110
                 ....*....|....*....|....*....|...
gi 543173144 131 TVLATLYAAKKYIVPHLARACVNFLETSLSAKN 163
Cdd:cd18237   91 NVQSLLDAANQYQIEPVKKMCVDFLKEQLDASN 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543173144  50 AMMFNNDLMADVHFVVGppggTQRLPGHKYVLAVGSSVFHAmfygELAEDKDEIRIPDVEPAAFLAMLKYIYCDEIDLAA 129
Cdd:cd18303   10 ASLFDKELYSDITIKLA----DKSIPAHKFVLAARSEKWSN----ENLASTNELDLSDISYEVVLALLRWLYTDELDLTL 81

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 543173144 130 DTVLAT--LYAAKKYIVPHLARACVNFLETSLSAKNaCV 166
Cdd:cd18303   82 DDEFLLelMKAAKRFQLTDLVERCERALMSSVNVDN-CI 119

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543173144  53 FNNDLMADVHFVVGppggTQRLPGHKYVLAVGSSVFHAMFYGELAE-DKDEIRIPDVEPAAFLAMLKYIYCDEIDLAADT 131
Cdd:cd18314    1 YNDSEFSDVVLCVG----DRKFFAHRIVLCARSPVFRSMLTGSMIEsNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEEN 76

                         90       100
                 ....*....|....*....|
gi 543173144 132 VLATLYAAKKYIVPHLARAC 151
Cdd:cd18314   77 VLDLLMLASKYQVPDLEKLC 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543173144  53 FNNDLMADVHFVV-GPPggtqrLPGHKYVLAVGSSVFHAMFYGELAE-DKDEIRIPDVEPAAFLAMLKYIYC---DEIDL 127
Cdd:cd18297    7 VNNPEMSDVTFLVeGRP-----FYAHKIVLVTASDRFKSMLSSGSTEaQTPVIEIPDIRYDIFQLMMQYLYTggvESLDV 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 543173144 128 AADTVLATLYAAKKYIVPHLARACVNFLETSLSAKN 163
Cdd:cd18297   82 AQDDALELLRAASFFQLDGLKRHCEILLSQQIDLDN 117

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543173144  60 DVHFVVGppggTQRLPGHKYVLAVGSSVFHAMFYGELAEDK------DEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVL 133
Cdd:cd18296   19 DVCFQVE----GHRFPCHKAFFCGRSDYFKALLRDHFAESEenngsiPVVTLHDVSPEVFAIVLYYIYTDDTDLPPENAY 94

                         90       100
                 ....*....|....*....|....*.
gi 543173144 134 ATLYAAKKYIVPHLARACVNFLETSL 159
Cdd:cd18296   95 DVLYVADMYLLPGLKRLCGTVLAQSL 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543173144  70 GTQRLPGHKYVLAVGSSVFHAMFYGELAEDKD-EIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLA 148
Cdd:cd18269   35 GDKEFPCHRLVLAACSPYFRAMFLSDLEESKKkEVVLEDVDPDVMGMILKYLYTSEIDLNDQNVQDIFALASRFQIPSIF 114

                         90
                 ....*....|....*
gi 543173144 149 RACVNFLETSLSAKN 163
Cdd:cd18269  115 TVCVSYLQKRLSLSN 129

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543173144  60 DVHFVVGPpggtQRLPGHKYVLAVGSSVFHAMFYGELAED-KDEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYA 138
Cdd:cd18256   22 DVQLQVGM----ELFSVHRLVLAASSPYFAALFAGGMSESsKDVVQIHGVEPDIFHILLDFIYTGVVEVTVSNVQELLVA 97

                         90       100
                 ....*....|....*....|....*.
gi 543173144 139 AKKYIVPHLARACVNFLETSLSAKNA 164
Cdd:cd18256   98 ADMLQLTEVVEICCEFLKGQLHPSNC 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543173144  70 GTQRLPGHKYVLAVGSSVFHAMFYGELAEDK-DEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLA 148
Cdd:cd18341   35 GDKSLPCHRLILAACSPYFREYFLSEESEEKkKEVVLDNVDPNIMDMILKYLYSAEIDLNDGNVQDIFALASRFQIPSVF 114

                         90
                 ....*....|....*
gi 543173144 149 RACVNFLETSLSAKN 163
Cdd:cd18341  115 TVCVTYLQKRLSPAN 129

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543173144  70 GTQRLPGHKYVLAVGSSVFHAMFYGELAEDKD-EIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLA 148
Cdd:cd18340   35 KEKEFPCHRLVLAACSPYFRAMFLSDLEESKKrEIVLEDVDPDVMGKILHYIYTSEIEITEQNVQDIFAAANMFQIPSIF 114

                         90
                 ....*....|....*
gi 543173144 149 RACVNFLETSLSAKN 163
Cdd:cd18340  115 TVCVSFLQKRLCLSN 129

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543173144  42 YPTIRErnamMFNNDLMADVHFVVGppggTQRLPGHKYVLAVGSSVFHAMFYGELAEDK-DEIRIPDVEPAAFLAMLKYI 120
Cdd:cd18247    7 FPVMEE----IRRQGKLCDVTLKVG----DQKFSAHRIVLAATIPYFHAMFTHDMVESKqDEITMQGIEPSALEALINFA 78

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 543173144 121 YCDEIDLAADTVLATLYAAKKYIVPHLARACVNFLET 157
Cdd:cd18247   79 YSGRIAIDTSNVQSLLVGASFLQLQSVKDACCEFLKE 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543173144  52 MFNNDLMADVHFVVGppggTQRLPGHKYVLAVGSSVFHAMFYGELAEDK-DEIRIPDVEPAAFLAMLKYIYCDE---IDL 127
Cdd:cd18345   12 LFERSAFSDVTLCVG----GREFQAHKAILAARSPVFNAMFEHEMEERKqNRVEITDVDHEVMREMLRFIYTGKapnLDK 87

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 543173144 128 AADTVLAtlyAAKKYIVPHLARACVNFLETSLSAKNA 164
Cdd:cd18345   88 MADDLLA---AADKYALERLKVMCEEALCSNLSVENV 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543173144  70 GTQRLPGHKYVLAVGSSVFHAMFYGELAEDK-DEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLA 148
Cdd:cd18336   27 GNLKIPAHRLVLSAVSDYFAAMFTNDVREAKqEEIKMEGVDPDALKALVHYAYTGVLELKEDTIESLLAAACLLQLSQVI 106

                         90
                 ....*....|....*
gi 543173144 149 RACVNFLETSLSAKN 163
Cdd:cd18336  107 DVCCNFLMKQLHPSN 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.