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Conserved domains on  [gi|523498712|ref|NP_001265648|]
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synaptic vesicle glycoprotein 2A isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
synapt_SV2 super family cl31090
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 11-194 9.36e-123

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


The actual alignment was detected with superfamily member TIGR01299:

Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 363.53  E-value: 9.36e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712   11 TDLFEYKFVNSRLINSTFLHNKEGCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVS 90
Cdd:TIGR01299 559 TDFEEYKFIDSEFQNCSFLHNKEGCPIDFDGDDEGAYMIYFVNFLGTLAVLPGNIVSALLMDKIGRLRMLAGSMVLSCIS 638

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712   91 CFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILF 170
Cdd:TIGR01299 639 CFFLSFGNSESAMIALLCLFGGLSIAAWNALDVLTVELYPSDKRATAFGFLNALCKAAAVLGILIFGSFVGITKAAPILF 718

                         170       180
                  ....*....|....*....|....
gi 523498712  171 ASAALALGSSLALKLPETRGQVLQ 194
Cdd:TIGR01299 719 ASAALACGGLLALKLPDTRGQVLM 742
 
Name Accession Description Interval E-value
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 11-194 9.36e-123

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 363.53  E-value: 9.36e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712   11 TDLFEYKFVNSRLINSTFLHNKEGCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVS 90
Cdd:TIGR01299 559 TDFEEYKFIDSEFQNCSFLHNKEGCPIDFDGDDEGAYMIYFVNFLGTLAVLPGNIVSALLMDKIGRLRMLAGSMVLSCIS 638

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712   91 CFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILF 170
Cdd:TIGR01299 639 CFFLSFGNSESAMIALLCLFGGLSIAAWNALDVLTVELYPSDKRATAFGFLNALCKAAAVLGILIFGSFVGITKAAPILF 718

                         170       180
                  ....*....|....*....|....
gi 523498712  171 ASAALALGSSLALKLPETRGQVLQ 194
Cdd:TIGR01299 719 ASAALACGGLLALKLPDTRGQVLM 742
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 11-189 1.72e-109

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 321.21  E-value: 1.72e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  11 TDLFEYKFVNSRLINSTFLHNkEGCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVS 90
Cdd:cd17439  301 TDLFEYKFINSKLINSTFLHN-KEGCLLDFSDENNAYMIYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVS 379

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  91 CFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILF 170
Cdd:cd17439  380 CFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAVPILL 459

                        170
                 ....*....|....*....
gi 523498712 171 ASAALALGSSLALKLPETR 189
Cdd:cd17439  460 ASAALAAGSSLALKLPETR 478
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
51-183 8.36e-10

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 56.80  E-value: 8.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  51 FVSFLGTLAVLPGNIVSALLMDKIGRLR--MLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVEL 128
Cdd:COG2271  220 LLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAEL 299

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 523498712 129 YPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLAL 183
Cdd:COG2271  300 FPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLA 354
MFS_1 pfam07690
Major Facilitator Superfamily;
51-189 4.69e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 45.87  E-value: 4.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712   51 FVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYP 130
Cdd:pfam07690  36 LLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFP 115

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 523498712  131 SDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLALKLPETR 189
Cdd:pfam07690 116 PEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPP 174
 
Name Accession Description Interval E-value
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 11-194 9.36e-123

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 363.53  E-value: 9.36e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712   11 TDLFEYKFVNSRLINSTFLHNKEGCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVS 90
Cdd:TIGR01299 559 TDFEEYKFIDSEFQNCSFLHNKEGCPIDFDGDDEGAYMIYFVNFLGTLAVLPGNIVSALLMDKIGRLRMLAGSMVLSCIS 638

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712   91 CFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILF 170
Cdd:TIGR01299 639 CFFLSFGNSESAMIALLCLFGGLSIAAWNALDVLTVELYPSDKRATAFGFLNALCKAAAVLGILIFGSFVGITKAAPILF 718

                         170       180
                  ....*....|....*....|....
gi 523498712  171 ASAALALGSSLALKLPETRGQVLQ 194
Cdd:TIGR01299 719 ASAALACGGLLALKLPDTRGQVLM 742
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 11-189 1.72e-109

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 321.21  E-value: 1.72e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  11 TDLFEYKFVNSRLINSTFLHNkEGCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVS 90
Cdd:cd17439  301 TDLFEYKFINSKLINSTFLHN-KEGCLLDFSDENNAYMIYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVS 379

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  91 CFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILF 170
Cdd:cd17439  380 CFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAVPILL 459

                        170
                 ....*....|....*....
gi 523498712 171 ASAALALGSSLALKLPETR 189
Cdd:cd17439  460 ASAALAAGSSLALKLPETR 478
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
 11-189 3.25e-100

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 297.48  E-value: 3.25e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  11 TDLFEYKFVNSRLINSTFLHnKEGCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVS 90
Cdd:cd17363  297 TDLFEYKFIDSRFLNSTFFL-KEKCGCHLNDDEENAYLIYLVSFLGSLSVLPGNIVSALLMDKIGRLKMIGGSMLLSAVC 375

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  91 CFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILF 170
Cdd:cd17363  376 CFFLFFGNSESAMIGLQCLFCGVSIAAWNALDVVTVELYPTDKRATAFGFLNGLCKLAAILGNSIFGSFVGITKVIPILL 455

                        170
                 ....*....|....*....
gi 523498712 171 ASAALALGSSLALKLPETR 189
Cdd:cd17363  456 ASAALVCGGLLALKLPETR 474
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 11-189 5.87e-79

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 243.29  E-value: 5.87e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  11 TDLFEYKFVNSRLINSTFLHNKEGCPLDVTGtgEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVS 90
Cdd:cd17438  301 TDLYEHKFIDCRFINSTFLEQKEGCHMDFEE--DNDFLIYLVSFLGSLSVLPGNIISALLMDKIGRIKMIGGSMLISAVC 378

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  91 CFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILF 170
Cdd:cd17438  379 CFFLFFGNSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNKRATAFGILNGLCKFAAILGNSIFASFVGITKVIPILL 458

                        170
                 ....*....|....*....
gi 523498712 171 ASAALALGSSLALKLPETR 189
Cdd:cd17438  459 ASTALVGGGLISLRLPETR 477
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
 11-189 6.91e-74

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 230.18  E-value: 6.91e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  11 TDLFEYKFVNSRLINSTFLHNKEGCPLDVTgTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVS 90
Cdd:cd17440  302 TDLEDYKFIDSDFINCTFFHNKTGCQITFD-DDYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGIS 380

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  91 CFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILF 170
Cdd:cd17440  381 CFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVGITKAIPILL 460

                        170
                 ....*....|....*....
gi 523498712 171 ASAALALGSSLALKLPETR 189
Cdd:cd17440  461 ASTVLVCGGLVGLRLPDTR 479
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 49-183 1.75e-13

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 67.63  E-value: 1.75e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  49 VYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSC--FFLSFGNSESAMIALLCLFGGVSIASWNALDVLTV 126
Cdd:cd17316  215 SSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILAlpLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLA 294

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 523498712 127 ELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFV--GITKAAPILFASAALALGSSLAL 183
Cdd:cd17316  295 ELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLasTGGTGVPALILALLAIVALIVAL 353
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 34-193 1.32e-12

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 65.42  E-value: 1.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712   34 GCPLDVTGTGEGAYMVYFVSflgTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSE--SAMIALLCLFG 111
Cdd:TIGR00898 345 GLVLDLGNLGGNIYLDLFIS---GLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVPVDlyFLRTALAVLGK 421

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  112 GVSIASWNALDVLTVELYPSDKRTTAFGflnaLCKLAAVLGiSIFTSFVGITKAAP-----ILFASAALaLGSSLALKLP 186
Cdd:TIGR00898 422 FGITSAFQMVYLYTAELYPTVVRNLGVG----VCSTMARVG-SIISPFLVYLGEKWlflplVLFGGLAL-LAGILTLFLP 495


                  ....*..
gi 523498712  187 ETRGQVL 193
Cdd:TIGR00898 496 ETKGVPL 502
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
51-183 8.36e-10

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 56.80  E-value: 8.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  51 FVSFLGTLAVLPGNIVSALLMDKIGRLR--MLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVEL 128
Cdd:COG2271  220 LLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAEL 299

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 523498712 129 YPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLAL 183
Cdd:COG2271  300 FPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLA 354
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 49-186 3.04e-09

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 55.28  E-value: 3.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  49 VYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGS---SVMSCVSCFFLSFGNSESAMIALLCLFGGVSiASWNALDVLT 125
Cdd:cd17317  193 LYLNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSlllAGLACLVTALLPDDENTLALTLALVGKFAIS-AAFSVIYLYT 271

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 523498712 126 VELYPSDKRTTAFGFLNALCKLAAVLgISIFTSFVGITKAAP-ILFASAALaLGSSLALKLP 186
Cdd:cd17317  272 AELYPTVVRNTGVGLCSTVARVGAIL-APFIVLLGKIGPLLPlIIFGVLAL-LGGLLTLLLP 331
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 50-151 1.10e-06

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 47.91  E-value: 1.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  50 YFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAgsSVMSCVSCFFLSFGNSESAMIALLCLFGGVSI--ASWNALDVLTVE 127
Cdd:cd17372  232 YRDVFIATFAEFPGLLISAAMIDRLGRKASMA--SMLFTCCIFLLLLLICQSPFILTVLLFGGRACisAAFTVVYIYTPE 309

                         90       100
                 ....*....|....*....|....
gi 523498712 128 LYPSDKRTTAFGFLNALCKLAAVL 151
Cdd:cd17372  310 VYPTAVRALGVGTGSSVGRIGAIL 333
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
43-151 2.23e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 46.89  E-value: 2.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  43 GEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGGVSIASWNALD 122
Cdd:COG2814  239 GLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQ 318

                         90       100
                 ....*....|....*....|....*....
gi 523498712 123 VLTVELYPSDKRTTAFGFLNALCKLAAVL 151
Cdd:COG2814  319 ALVAELAPPEARGRASGLYNSAFFLGGPL 347
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 48-191 3.18e-06

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 46.30  E-value: 3.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  48 MVYFVSFLGTLAVlpgnivsALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVE 127
Cdd:COG2270  282 LVQIVAALGALLF-------GRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSRSLLAR 354

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 523498712 128 LYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAP--ILFASAALALGSSLALKLPETRGQ 191
Cdd:COG2270  355 LIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLTGSQRlgILSLIVFFVIGLVLLLRVKVPRGR 420
MFS_1 pfam07690
Major Facilitator Superfamily;
51-189 4.69e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 45.87  E-value: 4.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712   51 FVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYP 130
Cdd:pfam07690  36 LLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFP 115

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 523498712  131 SDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLALKLPETR 189
Cdd:pfam07690 116 PEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPP 174
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 36-187 5.10e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 45.64  E-value: 5.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  36 PLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGGVSI 115
Cdd:cd17325   20 PLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASA 99

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 523498712 116 ASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISI---FTSFVGItkAAPILFASAALALGSSLALKLPE 187
Cdd:cd17325  100 AVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLgglLADALGY--RAPFLVCAALALLALVLALLLLP 172
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 58-194 5.10e-06

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 46.03  E-value: 5.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  58 LAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSF---------GNSESAMIALLCLFGGVSIAS-------Wnal 121
Cdd:cd17358  285 VVQVVGTLVATLLVDRLGRRPLLLVSAIGMGIGLLALGLyfylqehgaLLSSVSWLPLVGLVIYIISFSiglgplpW--- 361

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 523498712 122 dVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSL--ALKLPETRGQVLQ 194
Cdd:cd17358  362 -VIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTFPFLTLAWGASGTFWIFAGICGLALVfvLLFVPETKGKSLE 435
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
 34-160 5.98e-06

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 45.43  E-value: 5.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  34 GCPLDVTGTGegaYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMS---CVSCFFLSFGNSESAMIAL-LCL 109
Cdd:cd17378  191 GIPLAVGNLK---FNIYLSVALNALSELPAFVITAFLLDRFGRRPSLLGFTLLSgasCLLCFVLSIGGTTSLQIALeLVG 267

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 523498712 110 FGGVSIAsWNALDVLTVELYPSDKRTTAFGFLNAlcklAAVLGiSIFTSFV 160
Cdd:cd17378  268 FFGAAGA-FNLLYIYTVELFPTCVRNAALGMLRQ----ALVVG-GIFAPFI 312
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 36-188 6.17e-06

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 45.76  E-value: 6.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  36 PLDVTGTGEGAYMVYFV--SFLGTLAvlpgnivSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGN-SESAMIALLCLFGG 112
Cdd:cd17371  239 ERGLSFEGSAGYLVVTIlgGFLGYLA-------GGFLADRIGRRNNFALFALGSAISILLYFFLPlSPTLILILGFPLGF 311

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 523498712 113 VSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFV--GITKAAPILFASAALALGSSLALKLPET 188
Cdd:cd17371  312 FASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLAtsGSLGTAIAVFAAVYYIAGLVLALLLPET 389
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
43-189 2.87e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 43.42  E-value: 2.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  43 GEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGGVSIASWNALD 122
Cdd:COG2814   41 GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAAL 120

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 523498712 123 VLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLAL--KLPETR 189
Cdd:COG2814  121 ALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLlrLLPESR 189
Sugar_tr pfam00083
Sugar (and other) transporter;
37-193 3.30e-05

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 43.41  E-value: 3.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712   37 LDVTGTGEGAYMVYFVSFLGTlavlpgnIVSALLMDKIGRLRMLAGSSVMSCVSCFFLS----FGNSES-----AMIALL 107
Cdd:pfam00083 284 LGLSDSFLVTIIVGVVNFVFT-------FIAIFLVDRFGRRPLLLLGAAGMAICFVILGivalLGVSKSdwagiVAIVFI 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  108 CLFGGVSIASWNALD-VLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAP--ILFASAALALGSSLALK 184
Cdd:pfam00083 357 ALFIAFFAMGWGPVPwVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGYtfFIFAGLLVLFIIFVFFF 436


                  ....*....
gi 523498712  185 LPETRGQVL 193
Cdd:pfam00083 437 VPETKGRTL 445
MFS_1 pfam07690
Major Facilitator Superfamily;
36-152 5.38e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 42.79  E-value: 5.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712   36 PLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRML---AGSSVMSCVSCFFLSFGNSESAMIALLCLFGG 112
Cdd:pfam07690 224 PLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLllaLLLLILAALGLLLLSLTLSSLWLLLALLLLGF 303

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 523498712  113 VSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLG 152
Cdd:pfam07690 304 GFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
 46-150 7.51e-05

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 42.49  E-value: 7.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  46 AYMVYFVSFLGTLAVLPGNIvsaLLMDKIGRLRMLAgsSVMSCVSCFFL--SFGNSESAMIALLCLFGGVSIASWNALDV 123
Cdd:cd17442  238 DYQTMIISTLGEIALNPLNI---LGINFLGRRLSLV--ITMGLTAIFFLllNICTSSAGLTIFLFMLRALVSANFNTVYI 312

                         90       100
                 ....*....|....*....|....*..
gi 523498712 124 LTVELYPSDKRTTAFGFLNALCKLAAV 150
Cdd:cd17442  313 YTAEVYPTTMRALGMGTSGSLCRIGAM 339
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
51-152 8.13e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 42.16  E-value: 8.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  51 FVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYP 130
Cdd:COG2271   49 LLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFP 128

                         90       100
                 ....*....|....*....|..
gi 523498712 131 SDKRTTAFGFLNALCKLAAVLG 152
Cdd:COG2271  129 PKERGRALGIFNAGGPLGGALA 150
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
 50-186 8.16e-05

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 42.04  E-value: 8.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  50 YFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSE-SAMIALLCLFGGVSIASWNALDVL-TVE 127
Cdd:cd17375  204 YLNLFLVGAVEIPSYIIACIGMDKLGRRNTLAPFLLLSALACMLIMVIPQDyEVLTIVLSMTGKFAIAIAFGLIYLyTAE 283

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712 128 LYPSDKRTTAFGFLNALCKLAAVLG-ISIFTSFVGITkaAPILFASAALALGSSLALKLP 186
Cdd:cd17375  284 LYPTIVRSLAVGSGSMMCRVGSVVApFCVYLSDVWIF--LPQLLVGIMAFLSGILTLMLP 341
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 70-183 2.61e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 40.64  E-value: 2.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  70 LMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAA 149
Cdd:cd17325  258 LSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGM 337

                         90       100       110
                 ....*....|....*....|....*....|....
gi 523498712 150 VLGiSIFTSFVGITKAAPILFASAALALGSSLAL 183
Cdd:cd17325  338 VLG-PLLGGFLYDAFGFATPFLAAAALLLLAAVL 370
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 49-183 2.63e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 40.87  E-value: 2.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  49 VYFVSFLGTLAVLPGNIVSALLMDK-IGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVE 127
Cdd:cd06174  241 AGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 523498712 128 LYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLAL 183
Cdd:cd06174  321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
48-177 3.61e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 40.22  E-value: 3.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  48 MVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVE 127
Cdd:COG0738   44 QAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAA 123

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 523498712 128 LYPsDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALAL 177
Cdd:COG0738  124 LGP-ETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAV 172
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
43-163 4.43e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 40.27  E-value: 4.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  43 GEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSF-GNSESAMIALLCLFGGVSIASWNAL 121
Cdd:COG2211  260 GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFlGPGNLWLLLVLAALAGIGLGAILVL 339

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 523498712 122 ------DVLTVELYPSDKRTTA--FGFLNALCKLAAVLGISIFTSFVGIT 163
Cdd:COG2211  340 pwamlaDVVDYDEWKTGRRREGlyFGIFTFAIKLGQALAGALAGLLLALF 389
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 49-186 5.35e-04

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 39.58  E-value: 5.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  49 VYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAM--IALLCLFGGVSIASWNALDVLTV 126
Cdd:cd17374  203 VFLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILANIFVPQEMQTlrTVLAVLGKGSSAAAFTISYVYTA 282

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712 127 ELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALaLGSSLALKLP 186
Cdd:cd17374  283 ELFPTVLRQTGMGLNSMFARIGGILAPLIMLLGVYSPLLPMIIYGVLPI-LAGLLALLLP 341
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 57-178 5.84e-04

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 39.92  E-value: 5.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  57 TLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVS---CFFLSFGNSESAMIALLCLfGGVSIASWNALDVLTVEL-YPSD 132
Cdd:cd06179  308 GLGTLFGAILAGLLLTKIKHIKWQLVAGFVLFTAflaLLALITPDNKALAIAFSVL-AGIGIGGPLVLAIVIVQLsVPPE 386

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 523498712 133 KRTTAFGFLNALCKLAAVLGISIFTSFVG--ITKAAPILFASAALALG 178
Cdd:cd06179  387 DIGTASGLLGSARALGGAVGTAIFTSILSnrLSKNLPARVAPAALEAG 434
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
51-189 6.65e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 39.48  E-value: 6.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  51 FVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGGVSIASWNALD-VLTVELY 129
Cdd:COG2223  245 LLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVfALVPDIF 324

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 523498712 130 PSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKA-APILFASAALALGSSLALKLPETR 189
Cdd:COG2223  325 PTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSyTAAFLVFAVLALVALVLTLLLYRR 385
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 42-186 8.05e-04

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 39.11  E-value: 8.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  42 TGEGAYMVYFVSFLGTLavlpGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGGVSI-ASWNA 120
Cdd:cd17365  205 LSQALTITLLLNIGGVI----GSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGACVnGAQVG 280

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712 121 LDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILF----ASAALALGSSLALKLP 186
Cdd:cd17365  281 LYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFlalaIPAALGALAVLLLRLR 350
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 37-189 1.26e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 38.56  E-value: 1.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  37 LDVTGTGEGAYMVYFVSFLGTLAVLPgnIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGGVSIA 116
Cdd:cd06174   23 LQSFGLSASQLGLLFALFSLGYALLQ--PLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGL 100

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 523498712 117 SWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLG---ISIFTSFVGITKAAPILFASAALALGSSLALKLPETR 189
Cdd:cd06174  101 IDPAVLALIADLFPERERGRALGLLQAFGSVGGILGpllGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDP 176
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 56-161 2.09e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 37.92  E-value: 2.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  56 GTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSES---AMIALLCLFGGVSIASWNALDVLTVELYPSD 132
Cdd:cd17321  213 LALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSsvwLLLPGLVLLGLGLGLFATPLTNAALSSVPKE 292

                         90       100
                 ....*....|....*....|....*....
gi 523498712 133 KRTTAFGFLNALCKLAAVLGISIFTSFVG 161
Cdd:cd17321  293 KAGAASGILNTARQLGGALGVALLGALLT 321
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 64-183 2.60e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 37.91  E-value: 2.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  64 NIVSAL-------LMDKIGRLRMLAGSSVMSCVSCFFLSFGNSeSAMIALLCLFGGVSIASWNAL-DVLTVELYPSDKRT 135
Cdd:cd17370  244 NLVYALaaypagrLSDRIGRKKLLILGYLSLALAYLGFALGSS-LWLLLLGFILWGLYMGAQESIeRAAVADLVPAELRG 322

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 523498712 136 TAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLAL 183
Cdd:cd17370  323 TAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 38-183 4.30e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 37.21  E-value: 4.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  38 DVTGTGEGAY-MVYFVSFLGTLAvlpGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGGVSIA 116
Cdd:cd06173  237 EVLGGGAAGYgLLLAAFGVGALL---GALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGL 313

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 523498712 117 SWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLAL 183
Cdd:cd06173  314 FNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLL 380
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 34-186 4.98e-03

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 37.02  E-value: 4.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  34 GCPLDVTGTGegaYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMI--ALLCLFG 111
Cdd:cd17447  191 GISFNISGFG---LNVYLTQFIYGAIELPAKLLAYLLLDRIGRRLTQAGSLILTGLSIGINILIPSEFTVVrtVIAVLGK 267

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 523498712 112 GVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTsFVGITKAAPILFASAALALGSSLALKLP 186
Cdd:cd17447  268 GFSEAAFTTVFLYTSELYPTVLRQNGMGYTSFIARLGGSLAPLVIL-LDDVWLSLPQVIFCGVALLAGGVAFLLP 341
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 51-190 5.61e-03

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 36.86  E-value: 5.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  51 FVSFLGTlavlpgnIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFG------NSESAMIALLCLFG-------GVSIAS 117
Cdd:cd17357  304 IVNVLST-------IVGPFLIEKVGRRPLLLISLSVCAVALLLMSVFlflseqNSWMSYGCIVAIFLfifffaiGLGPIP 376

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 523498712 118 WnaldVLTVELYPSDKRTTAF---GFLNALCKLaaVLGISIFTSFVGITKAAPILFASAALALGSSLALKLPETRG 190
Cdd:cd17357  377 W----FIGAELFPQAPRSAAQslgSSVNWTSNF--IVGMAFPPLQSIGGGFVFIIFAIPCALFLLYLYRYLPETKG 446
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
 53-188 7.71e-03

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 36.20  E-value: 7.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498712  53 SFLGTLAVLPGNIVSAL----LMDKIGRLRMLAGSSVMSCVSCF--FLSFGNSES-----AMIALLCLFGGVSIAswnAL 121
Cdd:cd17368  260 SFLVTLLAGVANFIWAPlggaLSDRIGRRPVLLVITLAALVTLYpvFAWLTAAPSfgrllLVLLVLSFFFGMYGG---AM 336

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 523498712 122 DVLTVELYPSDKRTTAFGFLNAlcklaavLGISIFTSF----------VGITKAAPILFASAALALGSSLALKLPET 188
Cdd:cd17368  337 VVALVELFPVRVRSTGFSLVYA-------LAVAIFGGFaqfivtwlieLTGSPLAPAWYLMGAALLGLLATLMLRET 406
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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