NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|523425724|ref|NP_001265627|]
View 

DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 1 [Homo sapiens]

Protein Classification

RPOL8c domain-containing protein( domain architecture ID 10652794)

RPOL8c domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
RPOL8c smart00658
RNA polymerase subunit 8; subunit of RNA polymerase I, II and III
2-106 5.52e-61

RNA polymerase subunit 8; subunit of RNA polymerase I, II and III


:

Pssm-ID: 197821  Cd Length: 143  Bit Score: 185.68  E-value: 5.52e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523425724     2 AGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVIASTLYEDGTLDDGEYNPTDDR 81
Cdd:smart00658   1 AIILFEDIFKVKSVDPDGKKFDKVSRIFAESEYLQMELILDINSEIYPLAVGDKFRLVIASTLNEDGTPDSGENNPIALI 80
                           90       100
                   ....*....|....*....|....*
gi 523425724    82 PSRADQFEYVMYGKVYRIEGDETST 106
Cdd:smart00658  81 KSLADKYEYVMYGKVYRIEEDKTET 105
 
Name Accession Description Interval E-value
RPOL8c smart00658
RNA polymerase subunit 8; subunit of RNA polymerase I, II and III
2-106 5.52e-61

RNA polymerase subunit 8; subunit of RNA polymerase I, II and III


Pssm-ID: 197821  Cd Length: 143  Bit Score: 185.68  E-value: 5.52e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523425724     2 AGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVIASTLYEDGTLDDGEYNPTDDR 81
Cdd:smart00658   1 AIILFEDIFKVKSVDPDGKKFDKVSRIFAESEYLQMELILDINSEIYPLAVGDKFRLVIASTLNEDGTPDSGENNPIALI 80
                           90       100
                   ....*....|....*....|....*
gi 523425724    82 PSRADQFEYVMYGKVYRIEGDETST 106
Cdd:smart00658  81 KSLADKYEYVMYGKVYRIEEDKTET 105
RNA_pol_Rpb8 pfam03870
RNA polymerase Rpb8; Rpb8 is a subunit common to the three yeast RNA polymerases, pol I, II ...
10-109 2.47e-56

RNA polymerase Rpb8; Rpb8 is a subunit common to the three yeast RNA polymerases, pol I, II and III. Rpb8 interacts with the largest subunit Rpb1, and with Rpb3 and Rpb11, two smaller subunits.


Pssm-ID: 461079  Cd Length: 136  Bit Score: 173.44  E-value: 2.47e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523425724   10 FDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVIASTLYEDGTLDDGEYNPT---DDRPSRAD 86
Cdd:pfam03870   1 FTVTDVDPDGKKFDRVSRIEATSESFDMDLTLDINTELYPVKVGDKFTLVLASTLSLDGTPDDGEYDQSwrpPGEPSLAD 80
                          90       100
                  ....*....|....*....|...
gi 523425724   87 QFEYVMYGKVYRIEGDETSTEAA 109
Cdd:pfam03870  81 DYDYVMYGKVYKFEEEESGDKVA 103
PTZ00167 PTZ00167
RNA polymerase subunit 8c; Provisional
2-110 1.69e-17

RNA polymerase subunit 8c; Provisional


Pssm-ID: 185493  Cd Length: 144  Bit Score: 74.81  E-value: 1.69e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523425724   2 AGILFEDIFDVKDIDpeGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDlgDKFRLVIASTLYEDGTLDDGEYNPTDDr 81
Cdd:PTZ00167   4 PSCLFEDRFVVRSVD--NSKFERVSRIKAKSTGFDAELILDINSDLFPVR--EKQSLYIGLTNQLSSGPDDNVWESSEP- 78
                         90       100
                 ....*....|....*....|....*....
gi 523425724  82 PSRADQFEYVMYGKVYRIEgdETSTEAAT 110
Cdd:PTZ00167  79 QSLMDQYEYVMYGKIFKFE--EKSSERRT 105
 
Name Accession Description Interval E-value
RPOL8c smart00658
RNA polymerase subunit 8; subunit of RNA polymerase I, II and III
2-106 5.52e-61

RNA polymerase subunit 8; subunit of RNA polymerase I, II and III


Pssm-ID: 197821  Cd Length: 143  Bit Score: 185.68  E-value: 5.52e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523425724     2 AGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVIASTLYEDGTLDDGEYNPTDDR 81
Cdd:smart00658   1 AIILFEDIFKVKSVDPDGKKFDKVSRIFAESEYLQMELILDINSEIYPLAVGDKFRLVIASTLNEDGTPDSGENNPIALI 80
                           90       100
                   ....*....|....*....|....*
gi 523425724    82 PSRADQFEYVMYGKVYRIEGDETST 106
Cdd:smart00658  81 KSLADKYEYVMYGKVYRIEEDKTET 105
RNA_pol_Rpb8 pfam03870
RNA polymerase Rpb8; Rpb8 is a subunit common to the three yeast RNA polymerases, pol I, II ...
10-109 2.47e-56

RNA polymerase Rpb8; Rpb8 is a subunit common to the three yeast RNA polymerases, pol I, II and III. Rpb8 interacts with the largest subunit Rpb1, and with Rpb3 and Rpb11, two smaller subunits.


Pssm-ID: 461079  Cd Length: 136  Bit Score: 173.44  E-value: 2.47e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523425724   10 FDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVIASTLYEDGTLDDGEYNPT---DDRPSRAD 86
Cdd:pfam03870   1 FTVTDVDPDGKKFDRVSRIEATSESFDMDLTLDINTELYPVKVGDKFTLVLASTLSLDGTPDDGEYDQSwrpPGEPSLAD 80
                          90       100
                  ....*....|....*....|...
gi 523425724   87 QFEYVMYGKVYRIEGDETSTEAA 109
Cdd:pfam03870  81 DYDYVMYGKVYKFEEEESGDKVA 103
PTZ00167 PTZ00167
RNA polymerase subunit 8c; Provisional
2-110 1.69e-17

RNA polymerase subunit 8c; Provisional


Pssm-ID: 185493  Cd Length: 144  Bit Score: 74.81  E-value: 1.69e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523425724   2 AGILFEDIFDVKDIDpeGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDlgDKFRLVIASTLYEDGTLDDGEYNPTDDr 81
Cdd:PTZ00167   4 PSCLFEDRFVVRSVD--NSKFERVSRIKAKSTGFDAELILDINSDLFPVR--EKQSLYIGLTNQLSSGPDDNVWESSEP- 78
                         90       100
                 ....*....|....*....|....*....
gi 523425724  82 PSRADQFEYVMYGKVYRIEgdETSTEAAT 110
Cdd:PTZ00167  79 QSLMDQYEYVMYGKIFKFE--EKSSERRT 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH