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Conserved domains on  [gi|451958117|ref|NP_001263613|]
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activity-regulated cytoskeleton-associated protein [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arc_MA pfam19284
Arc MA domain; This is the N-terminal matrix-like domain (MA) of Activity-Regulated ...
 46-154 5.48e-68

Arc MA domain; This is the N-terminal matrix-like domain (MA) of Activity-Regulated Cytoskeleton-Associated protein (Arc). This domain might be involved in stabilising the relative domain orientations of the capside-like domain (CA) upon capsid assembly. Arc is a regulator of synaptic scaling and dendrite remodelling.


:

Pssm-ID: 437116  Cd Length: 108  Bit Score: 210.17  E-value: 5.48e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451958117   46 HRHLLTEVSKQVERELKGLHRSVGKLENNLDGYVPTGDSQRWKKSIKACLCRCQETIANLERWVKREMHVWREVFYRLER 125
Cdd:pfam19284   1 HRHLLSEVSRQVERELKGLHRSVGKLESNLDDYVPAIDSQRWKKSIKACLIRCQETIANLERWVKREMNVWREVFYRLEK 80

                          90       100
                  ....*....|....*....|....*....
gi 451958117  126 WADRLESMGGKYPVGSEpARHTVSVGVGG 154
Cdd:pfam19284  81 WADRLEQMGGKYPKGDQ-ARRTVSVGVGG 108
Arc_C super family cl39536
Arc C-lobe; This is the C-terminal domain of Arc protein present in found in Rattus norvegicus. ...
 278-355 5.74e-43

Arc C-lobe; This is the C-terminal domain of Arc protein present in found in Rattus norvegicus. The Arc protein modulates the trafficking of AMPA-type glutamate receptors. This domains tertiary structure is similar to the capsid domain of HIV gag protein. The domain is thought to have evolved from the capsid domain of Ty3/Gypsy retrotransposon.


The actual alignment was detected with superfamily member pfam18162:

Pssm-ID: 465670  Cd Length: 83  Bit Score: 144.84  E-value: 5.74e-43
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 451958117  278 TLSREAIQRELELPQKQGEPLDQFLWRKRDLYQTLYVDAEEEEIIQYVVGTLQPKLKRFLRHPLPKTLEQLIQRGMEV 355
Cdd:pfam18162   1 TLTRDAIKRELDLPQKQGEPLDEFLWRKRDLYQTLYTDAEEEEIIQYVVGTLRPKFKRFLSHPLPKTLEQLIQRGKEV 78
 
Name Accession Description Interval E-value
Arc_MA pfam19284
Arc MA domain; This is the N-terminal matrix-like domain (MA) of Activity-Regulated ...
 46-154 5.48e-68

Arc MA domain; This is the N-terminal matrix-like domain (MA) of Activity-Regulated Cytoskeleton-Associated protein (Arc). This domain might be involved in stabilising the relative domain orientations of the capside-like domain (CA) upon capsid assembly. Arc is a regulator of synaptic scaling and dendrite remodelling.


Pssm-ID: 437116  Cd Length: 108  Bit Score: 210.17  E-value: 5.48e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451958117   46 HRHLLTEVSKQVERELKGLHRSVGKLENNLDGYVPTGDSQRWKKSIKACLCRCQETIANLERWVKREMHVWREVFYRLER 125
Cdd:pfam19284   1 HRHLLSEVSRQVERELKGLHRSVGKLESNLDDYVPAIDSQRWKKSIKACLIRCQETIANLERWVKREMNVWREVFYRLEK 80

                          90       100
                  ....*....|....*....|....*....
gi 451958117  126 WADRLESMGGKYPVGSEpARHTVSVGVGG 154
Cdd:pfam19284  81 WADRLEQMGGKYPKGDQ-ARRTVSVGVGG 108
Arc_C pfam18162
Arc C-lobe; This is the C-terminal domain of Arc protein present in found in Rattus norvegicus. ...
 278-355 5.74e-43

Arc C-lobe; This is the C-terminal domain of Arc protein present in found in Rattus norvegicus. The Arc protein modulates the trafficking of AMPA-type glutamate receptors. This domains tertiary structure is similar to the capsid domain of HIV gag protein. The domain is thought to have evolved from the capsid domain of Ty3/Gypsy retrotransposon.


Pssm-ID: 465670  Cd Length: 83  Bit Score: 144.84  E-value: 5.74e-43
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 451958117  278 TLSREAIQRELELPQKQGEPLDQFLWRKRDLYQTLYVDAEEEEIIQYVVGTLQPKLKRFLRHPLPKTLEQLIQRGMEV 355
Cdd:pfam18162   1 TLTRDAIKRELDLPQKQGEPLDEFLWRKRDLYQTLYTDAEEEEIIQYVVGTLRPKFKRFLSHPLPKTLEQLIQRGKEV 78
 
Name Accession Description Interval E-value
Arc_MA pfam19284
Arc MA domain; This is the N-terminal matrix-like domain (MA) of Activity-Regulated ...
 46-154 5.48e-68

Arc MA domain; This is the N-terminal matrix-like domain (MA) of Activity-Regulated Cytoskeleton-Associated protein (Arc). This domain might be involved in stabilising the relative domain orientations of the capside-like domain (CA) upon capsid assembly. Arc is a regulator of synaptic scaling and dendrite remodelling.


Pssm-ID: 437116  Cd Length: 108  Bit Score: 210.17  E-value: 5.48e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451958117   46 HRHLLTEVSKQVERELKGLHRSVGKLENNLDGYVPTGDSQRWKKSIKACLCRCQETIANLERWVKREMHVWREVFYRLER 125
Cdd:pfam19284   1 HRHLLSEVSRQVERELKGLHRSVGKLESNLDDYVPAIDSQRWKKSIKACLIRCQETIANLERWVKREMNVWREVFYRLEK 80

                          90       100
                  ....*....|....*....|....*....
gi 451958117  126 WADRLESMGGKYPVGSEpARHTVSVGVGG 154
Cdd:pfam19284  81 WADRLEQMGGKYPKGDQ-ARRTVSVGVGG 108
Arc_C pfam18162
Arc C-lobe; This is the C-terminal domain of Arc protein present in found in Rattus norvegicus. ...
 278-355 5.74e-43

Arc C-lobe; This is the C-terminal domain of Arc protein present in found in Rattus norvegicus. The Arc protein modulates the trafficking of AMPA-type glutamate receptors. This domains tertiary structure is similar to the capsid domain of HIV gag protein. The domain is thought to have evolved from the capsid domain of Ty3/Gypsy retrotransposon.


Pssm-ID: 465670  Cd Length: 83  Bit Score: 144.84  E-value: 5.74e-43
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 451958117  278 TLSREAIQRELELPQKQGEPLDQFLWRKRDLYQTLYVDAEEEEIIQYVVGTLQPKLKRFLRHPLPKTLEQLIQRGMEV 355
Cdd:pfam18162   1 TLTRDAIKRELDLPQKQGEPLDEFLWRKRDLYQTLYTDAEEEEIIQYVVGTLRPKFKRFLSHPLPKTLEQLIQRGKEV 78
Ty3_capsid pfam19259
Ty3 transposon capsid-like protein; This entry corresponds to the capsid protein found in the ...
 244-380 5.78e-03

Ty3 transposon capsid-like protein; This entry corresponds to the capsid protein found in the Ty3 transposons of yeast as well as other transposable elements.


Pssm-ID: 437091 [Multi-domain]  Cd Length: 197  Bit Score: 37.84  E-value: 5.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451958117  244 NHMNGPAKKWWEFKQGSVKN----WVEFKKEFLQYSEGTLSREAIQRELELPQKQGEPLDQFLWRKRDLYQTLYVD--AE 317
Cdd:pfam19259  54 RHLTGPAAQWFHDFVQEQGIldatFDTFIKAFKQHFYGKPDINKLFNDIVNLSEAKLGIERYNSHFNRLWDLLPPDflSE 133

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 451958117  318 EEEIIQYVVGtLQPKLKRFLRHPLPKTLEQLIQRGMEVqdgleQAAEPSGTPLPTEDETEALT 380
Cdd:pfam19259 134 KAAIMFYIRG-LKPETYIIVRLAKPSTLKEAMEIAYET-----IPYTERFSPTFTQNSKTVLD 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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