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Conserved domains on  [gi|442734435|ref|NP_001263186|]
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epididymal-specific lipocalin-5 isoform c precursor [Mus musculus]

Protein Classification

lipocalin/fatty acid-binding family protein( domain architecture ID 3669)

lipocalin/fatty acid-binding family protein contains a large beta-barrel cavity that binds hydrophobic ligands

CATH:  2.40.128.20
Gene Ontology:  GO:0036094
PubMed:  11058745|11058743
SCOP:  3001332

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
lipocalin_FABP super family cl10502
lipocalin/cytosolic fatty acid-binding protein family; Lipocalins are diverse, mainly low ...
 31-180 4.07e-57

lipocalin/cytosolic fatty acid-binding protein family; Lipocalins are diverse, mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules as well as membrane bound-receptors. They have a large beta-barrel ligand-binding cavity. Members include retinol-binding protein, retinoic acid-binding protein, complement protein C8 gamma, Can f 2, apolipoprotein D, extracellular fatty acid-binding protein, beta-lactoglobulin, oderant-binding protein, and bacterial lipocalin Blc. Lipocalins are involved in many important processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty acid-binding proteins also bind hydrophobic ligands in a non-covalent, reversible manner, and are involved in protection and shuttling of fatty acids within the cell, and in acquisition and removal of fatty acids from intracellular sites.


The actual alignment was detected with superfamily member cd19421:

Pssm-ID: 471979  Cd Length: 150  Bit Score: 176.65  E-value: 4.07e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442734435  31 VVKDFDVNKFLGFWYEIALASKMGAygLAHKEEKMGAMVVELKENLLALTTTYYNEGHCVLEKVAATQVDGSAKYKVTri 110
Cdd:cd19421    1 VVKDLDISKILGFWYEVAVASDQGL--VLHAEERVEGLFLTLSGNNLTVKTTYNSSGSCVLEKVTGSEGDGPGKFAFP-- 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442734435 111 sGEKEVVVVATDYMTYTVIDITSLVAGAVHRAMKLYSRSL-DNNGEALNNFQKIAlkhgfSETDIHILKHD 180
Cdd:cd19421   77 -GKREIHVLDTDYETYAILDITLLWAGRNFRVLKYFTRSLeDDDGEGFWNFREIT-----ADTGLYILARD 141
 
Name Accession Description Interval E-value
lipocalin_5_8-like cd19421
lipocalin similar to human epididymal-specific lipocalin-8, mouse lipocalin-5 and -8, and ...
 31-180 4.07e-57

lipocalin similar to human epididymal-specific lipocalin-8, mouse lipocalin-5 and -8, and similar proteins; Lipocalin 5 (LCN5; also known as epididymal retinoic acid binding protein Erabp, mouse epididymal protein 10, MEP10, and E-RABP) and Lipocalin 8 (LCN8; also known as mouse epididymal protein 17, MEP17) are homologous proteins belonging to the epididymis-specific lipocalins; they may play a role in male fertility, and may act as retinoid carrier proteins within the epididymis. In mice, genes encoding the two proteins are contiguous; in humans, there is one gene LCN8 (which has been previously called LCN5). This group belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381196  Cd Length: 150  Bit Score: 176.65  E-value: 4.07e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442734435  31 VVKDFDVNKFLGFWYEIALASKMGAygLAHKEEKMGAMVVELKENLLALTTTYYNEGHCVLEKVAATQVDGSAKYKVTri 110
Cdd:cd19421    1 VVKDLDISKILGFWYEVAVASDQGL--VLHAEERVEGLFLTLSGNNLTVKTTYNSSGSCVLEKVTGSEGDGPGKFAFP-- 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442734435 111 sGEKEVVVVATDYMTYTVIDITSLVAGAVHRAMKLYSRSL-DNNGEALNNFQKIAlkhgfSETDIHILKHD 180
Cdd:cd19421   77 -GKREIHVLDTDYETYAILDITLLWAGRNFRVLKYFTRSLeDDDGEGFWNFREIT-----ADTGLYILARD 141
Lipocalin pfam00061
Lipocalin / cytosolic fatty-acid binding protein family; Lipocalins are transporters for small ...
 41-179 1.07e-21

Lipocalin / cytosolic fatty-acid binding protein family; Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.


Pssm-ID: 395015  Cd Length: 143  Bit Score: 85.95  E-value: 1.07e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442734435   41 LGFWYEIALASKmgayglAHKEEKMGAMVVE------LKENLLALTTTYYNEGHCVLEKVAATQVDGSAKYKVT--RISG 112
Cdd:pfam00061   1 SGKWYLIASANF------NELEEEMKALGVGfatikvLENGNLPVTEITKEGGKCKTVSVTFKKTEEPGKLGVEfdEYAG 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442734435  113 EKEVVVVATDYMTYTVIDITSLVAGAVHRAMKLYSRSLDNNGEALNNFQKIALKHGFSETDIHILKH 179
Cdd:pfam00061  75 GRKVKVLTTDYDNYLIFYQKGDKDGKTTIVRELYGRDPELSPELLEKFKKFLKELGIDEENIVRLYQ 141
Blc COG3040
Bacterial lipocalin Blc [Cell wall/membrane/envelope biogenesis];
8-129 3.77e-05

Bacterial lipocalin Blc [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442274  Cd Length: 178  Bit Score: 42.14  E-value: 3.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442734435   8 MESIMLFTLLGLCVGLAAGTEA-----AVVKDFDVNKFLGFWYEIALaskmgaygLAHKEEKMGAMVVE---LKEN-LLA 78
Cdd:COG3040    1 MKRLRLLLALAAALLLAGCASAppppvTPVPPVDLDRYLGTWYEIAR--------LPHRFERGCVNVTAeysLREDgTIK 72

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442734435  79 LTTTYYN--EGHcvlEKVA---ATQVDGS--AKYKVT---RISGEKEVVVVATDYmTYTVI 129
Cdd:COG3040   73 VINRGRKgfDGE---WKEAegkARVVDDPtnAKLKVSffgPFYGDYWILALDPDY-QYALV 129
PRK10477 PRK10477
outer membrane lipoprotein Blc; Provisional
 31-48 2.68e-03

outer membrane lipoprotein Blc; Provisional


Pssm-ID: 182489  Cd Length: 177  Bit Score: 36.99  E-value: 2.68e-03
                         10
                 ....*....|....*...
gi 442734435  31 VVKDFDVNKFLGFWYEIA 48
Cdd:PRK10477  30 VVNNFDAKRYLGTWYEIA 47
 
Name Accession Description Interval E-value
lipocalin_5_8-like cd19421
lipocalin similar to human epididymal-specific lipocalin-8, mouse lipocalin-5 and -8, and ...
 31-180 4.07e-57

lipocalin similar to human epididymal-specific lipocalin-8, mouse lipocalin-5 and -8, and similar proteins; Lipocalin 5 (LCN5; also known as epididymal retinoic acid binding protein Erabp, mouse epididymal protein 10, MEP10, and E-RABP) and Lipocalin 8 (LCN8; also known as mouse epididymal protein 17, MEP17) are homologous proteins belonging to the epididymis-specific lipocalins; they may play a role in male fertility, and may act as retinoid carrier proteins within the epididymis. In mice, genes encoding the two proteins are contiguous; in humans, there is one gene LCN8 (which has been previously called LCN5). This group belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381196  Cd Length: 150  Bit Score: 176.65  E-value: 4.07e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442734435  31 VVKDFDVNKFLGFWYEIALASKMGAygLAHKEEKMGAMVVELKENLLALTTTYYNEGHCVLEKVAATQVDGSAKYKVTri 110
Cdd:cd19421    1 VVKDLDISKILGFWYEVAVASDQGL--VLHAEERVEGLFLTLSGNNLTVKTTYNSSGSCVLEKVTGSEGDGPGKFAFP-- 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442734435 111 sGEKEVVVVATDYMTYTVIDITSLVAGAVHRAMKLYSRSL-DNNGEALNNFQKIAlkhgfSETDIHILKHD 180
Cdd:cd19421   77 -GKREIHVLDTDYETYAILDITLLWAGRNFRVLKYFTRSLeDDDGEGFWNFREIT-----ADTGLYILARD 141
Lipocalin pfam00061
Lipocalin / cytosolic fatty-acid binding protein family; Lipocalins are transporters for small ...
 41-179 1.07e-21

Lipocalin / cytosolic fatty-acid binding protein family; Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.


Pssm-ID: 395015  Cd Length: 143  Bit Score: 85.95  E-value: 1.07e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442734435   41 LGFWYEIALASKmgayglAHKEEKMGAMVVE------LKENLLALTTTYYNEGHCVLEKVAATQVDGSAKYKVT--RISG 112
Cdd:pfam00061   1 SGKWYLIASANF------NELEEEMKALGVGfatikvLENGNLPVTEITKEGGKCKTVSVTFKKTEEPGKLGVEfdEYAG 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442734435  113 EKEVVVVATDYMTYTVIDITSLVAGAVHRAMKLYSRSLDNNGEALNNFQKIALKHGFSETDIHILKH 179
Cdd:pfam00061  75 GRKVKVLTTDYDNYLIFYQKGDKDGKTTIVRELYGRDPELSPELLEKFKKFLKELGIDEENIVRLYQ 141
lipocalin_L-PGDS cd19419
lipocalin-type prostaglandin D synthase; Lipocalin-type prostaglandin D synthase (L-PGDS; EC:5. ...
 33-177 6.14e-18

lipocalin-type prostaglandin D synthase; Lipocalin-type prostaglandin D synthase (L-PGDS; EC:5.3.99.2) is a secreted enzyme and the second most abundant protein in human cerebrospinal fluid. L-PGDS acts as both, an enzyme and as a lipid transporter, converting prostaglandin H2 to prostaglandin D2 and serving as a carrier for hydrophobic ligands including retinoids, hemoglobin metabolites, thyroid hormones, gangliosides, and fatty acids. L-PGDS belongs to the lipocalin/cytosolic fatty-acid binding protein family which has a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381194  Cd Length: 158  Bit Score: 76.62  E-value: 6.14e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442734435  33 KDFDVNKFLGFWYEIALASKmGAYGLAHKEE-KMGAMVVELKEN-LLALTTTYYNEGHC-----VLEKvaaTQVDGSAKY 105
Cdd:cd19419    3 PDFDLDKFAGRWYSVGLASN-SNWFVEKKAKlKMCTTVVAPTTDgNLNLTMTFLKKNGCetrtyLYEK---TEQPGRFTY 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442734435 106 KVTRISGEKEVVVVATDYMTYTVIdITSLVAGAVHRAM-KLYSRSLDNNGEALNNFQKIALKHGFSETDIHIL 177
Cdd:cd19419   79 KSPRWGSDHDVRVVETNYDEYALV-HTIKTKGNEEFTMvTLYSRTQTLRPELKEKFRQFAKAQGFTEENIVTL 150
lipocalin_FABP cd00301
lipocalin/cytosolic fatty acid-binding protein family; Lipocalins are diverse, mainly low ...
 39-148 4.33e-17

lipocalin/cytosolic fatty acid-binding protein family; Lipocalins are diverse, mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules as well as membrane bound-receptors. They have a large beta-barrel ligand-binding cavity. Members include retinol-binding protein, retinoic acid-binding protein, complement protein C8 gamma, Can f 2, apolipoprotein D, extracellular fatty acid-binding protein, beta-lactoglobulin, oderant-binding protein, and bacterial lipocalin Blc. Lipocalins are involved in many important processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty acid-binding proteins also bind hydrophobic ligands in a non-covalent, reversible manner, and are involved in protection and shuttling of fatty acids within the cell, and in acquisition and removal of fatty acids from intracellular sites.


Pssm-ID: 381182  Cd Length: 109  Bit Score: 72.96  E-value: 4.33e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442734435  39 KFLGFWYEIALASkmgaYGLAHKEEKMGAMVVEL-KENLLALTTTYYNEGHCVLEKVAATQVDGSAKYKVT--RISGEKE 115
Cdd:cd00301    1 KFSGKWYEVASAS----NAPEEDEGKCTTAEYTLeGNGNLKVTNSFVRDGVCKSITGTLKKTDGPGKFTVTypGYTGKNE 76

                         90       100       110
                 ....*....|....*....|....*....|...
gi 442734435 116 VVVVATDYMTYTVIDITSLVAGAVHRAMKLYSR 148
Cdd:cd00301   77 LYVLSTDYDNYAIVYSCKNLDGGHTVVAWLLSR 109
lipocalin_A1M-like cd19418
lipocalin domain of alpha1-microglobulin and similar proteins; Alpha(1)-microglobulin (A1M, ...
 31-178 6.61e-11

lipocalin domain of alpha1-microglobulin and similar proteins; Alpha(1)-microglobulin (A1M, also known as protein AMBP, alpha-1 microglycoprotein, and protein HC), has immunosuppressive properties, such as inhibition of antigen induced lymphocyte cell-proliferation, cytokine secretion, and oxidative burst of neutrophils. A1M may participate in the reducing and scavenging of biological pro-oxidants such as heme and heme-proteins. It binds heme strongly, and a C-terminally processed form of the protein degrades the heme. It can reduce cytochrome C, nitroblue tetrazolium, methemoglobin and free iron, using NADH, NADPH or ascorbate as cofactor. Intravenous administration of recombinant A1M in animal models eliminates or significantly reduces the manifestations of preeclampsia. A1M is a useful biomarker in clinical diagnostics for monitoring pre-eclampsia, hepatitis E, renal tubular dysfunction, and renal toxicity. A1M belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381193  Cd Length: 163  Bit Score: 58.23  E-value: 6.61e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442734435  31 VVKDFDVNKFLGFWYEIALASKmgAYGLAHKEEKMGAMVVELKE----NLLALTTTYYNEGHCV-----LEKvaaTQVDG 101
Cdd:cd19418    4 TQENFNLSRIYGKWYDLAVGST--CPWLKRIKDKMAIGTLVLQEgatgAELSMTRTRLRRGTCEeisgeYEK---TDTPG 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442734435 102 SAKYKVTRISGEKEVVVVATDYMTYTV-IDITSLVAGAVHRAMKLYSRSLDNNGEALNNFQKIALKHGFSETDIHILK 178
Cdd:cd19418   79 KFLYHKSKWNATVDAYVVHTNYDEYAIfLMKKFKRHGEPTTTLKLYGRTPQLRPTLLQDFRTLALEQGIPEDSIIIKA 156
lipocalin_C8gamma cd19417
complement protein C8 gamma; Human complement protein C8 gamma, together with C8alpha and ...
 32-171 1.96e-10

complement protein C8 gamma; Human complement protein C8 gamma, together with C8alpha and C8beta, form one of five components of the cytolytic membrane attack complex (MAC), a pore-like structure that assembles on bacterial membranes. C8alpha and C8gamma form a disulfide-linked heterodimer that is noncovalently associated with C8beta. MAC plays an important role in the defense against gram-negative bacteria and other pathogenic organisms. C8gamma belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381192  Cd Length: 162  Bit Score: 56.68  E-value: 1.96e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442734435  32 VKDFDVNKFLGFWYEIALASKmGAYGL--AHKEEKMgAMVVELKENLLALTTTYYNEGHC--VLEKVAATQVDGSAKYKV 107
Cdd:cd19417    3 AQNFDIQQFSGKWYLVAVASA-CRYLQesGHKVEAT-VLTVAPPKTTVAVSTFRKLNGICweIKQEYGKTGTLGRFLLKA 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442734435 108 TRISGEKEVVVVATDYMTYTVIditslvagAVHRA----MKLYSRSLDNNGEALNNFQKIALKHGFSE 171
Cdd:cd19417   81 RRPRGNTDIVVGETDYSSYAIL--------YYQRAgkltMKLYGRSTELSENILDKFEQRAQKAHLGL 140
lipocalin_Ex-FABP-like cd19439
extracellular fatty acid-binding protein; Ex-FABP (also known as siderocalin, lipocalin Q83 or ...
 38-177 3.33e-08

extracellular fatty acid-binding protein; Ex-FABP (also known as siderocalin, lipocalin Q83 or protein Ch21) displays a dual ligand binding mode as it can bind siderophore and fatty acids simultaneously. ExFABP has a cavity which extends through the protein and has two separate ligand specificities, one for bacterial siderophores at one end, and other specifically binding co-purified lysophosphatidic acid (LPA), a potent cell signaling molecule, at the other end. As well as acting as an LPA "sensor", Ex-FABP is bacteriostatic, and tightly binds the 2,3-catechol-type ferric siderophores enterobactin, bacillibactin, and parabactin, associated with enteric bacteria and Gram-positive bacilli. This group belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381214  Cd Length: 142  Bit Score: 50.36  E-value: 3.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442734435  38 NKFLGFWYEIALASKMGAygLAHKEEKMGAMVVE---LKENLLALTTTYYNEGHCVLEKVA--ATQVDGSAKYKVtriSG 112
Cdd:cd19439    2 SELAGKWYLVALASNTDF--FLREKGKMKMMMARisfLGEDELLVSYAFPSPGGCRKWETTfkKTSDDGEVYYSE---EA 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442734435 113 EKEVVVVATDYMTYTVIDITSLVAGAVHRAMKLYSRSLDNNGEALNNFQKIALKHGFSETDIHIL 177
Cdd:cd19439   77 RKTVEVLDTDYKSYAVIYATRVKDGRTLHMMRLYSRSQEVSPEAEAIFRKLAEERNYTDEMVAIL 141
lipocalin_beta-LG-like cd19416
beta-lactoglobulin and similar proteins; Beta-Lactoglobulin (beta-LG) is the major whey ...
 33-163 1.66e-07

beta-lactoglobulin and similar proteins; Beta-Lactoglobulin (beta-LG) is the major whey protein of ruminant species and present in the milk of many other species, with a notable exception of human. It is the major allergen of bovine milk. Beta-LG has been shown to bind hydrophobic ligands such as curcumin, vitamin E or fatty acids, or hydrophilic such as vitamin B9. This group also includes human glycodelin (also known as placental protein 14, pregnancy-associated endometrial alpha-2 globulin, and progestagen-associated endometrial protein) which is involved in crucial biological processes such as reproduction and immune reaction. Four glycoforms of glycodelin have been identified in reproductive tissue that differ in glycosylation and biological activity. This group belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381191  Cd Length: 160  Bit Score: 48.68  E-value: 1.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442734435  33 KDFDVNKFLGFWYEIALASKMgAYGLAHKEEKMGAMVVELK---ENLLALTTTYYNEGHCVLEKVAATQVDGSAKYKVTr 109
Cdd:cd19416    6 KDLDVQKVAGTWYSLAMAASD-ISLLDAQSAPLRVYIEELKptpEGNLEIVLQKWENGRCAEKKLLAEKTKIPAVFKIN- 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 442734435 110 ISGEKEVVVVATDYMTYTVIDITSLVAGAVHRAMKLYSRSLDNNGEALNNFQKI 163
Cdd:cd19416   84 ALNENKVLVLDTDYDSYLLFCMENSAEPEQSLACQCLVRTLEVDNEAMEKFDKA 137
lipocalin_9 cd19429
lipocalin 9; Lipocalin 9 (LCN9) is specifically expressed in the epididymis. It belongs to the ...
 28-174 3.35e-07

lipocalin 9; Lipocalin 9 (LCN9) is specifically expressed in the epididymis. It belongs to the lipocalin/cytosolic fatty-acid binding protein family. Lipocalins are typically small extracellular proteins that bind small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids and form covalent or non-covalent complexes with soluble macromolecules as well as membrane bound-receptors. They are involved in many important functions, like ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior.


Pssm-ID: 381204  Cd Length: 156  Bit Score: 47.91  E-value: 3.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442734435  28 EAAVVKDFDVNKFLGFWYEIALASKMGAYGLAHKEEKMGAMVVE-LKENLLALTTTYYNEGHCVLEKVAATQVDGSAKYK 106
Cdd:cd19429    1 HTAVRRDYNMARISGVWYSISMASDNMTRIEENGDLRLFIRNIElLNNGSLQFDFHFMLQGECVAVTVVCEKTKKNGEFS 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442734435 107 VTrISGEKEVVVVATDYMTYTVIDITSLVAGAVHRAMKLYSRSLDNNGEALNNFQKIALKHGFSETDI 174
Cdd:cd19429   81 IA-YEGENKVLLLETDYSMYIIFYLQNIRNGTETQVLALYGRSILLDKTHQRRFENICNKYGLGPRNT 147
lipocalin_MUP-like cd19428
major urinary proteins (MUPs) and similar proteins; Mouse urine contains major urinary ...
 30-174 1.57e-06

major urinary proteins (MUPs) and similar proteins; Mouse urine contains major urinary proteins (MUPs) which bind low molecular weight hydrophobic organic compounds such as urinary volatile pheromones such as the male-specific 2-sec-butyl-4,5-dihydrothiazole (SB2HT) which hastens puberty in female mice. The association between MUPs and these volatiles slows the release of the volatiles into the air from urine marks. MUPs may also act as pheromones themselves. MUPs, expressed in the nasal and vomeronasal mucosa, may be important for delivering urinary volatiles to receptors in the vomeronasal organ. This group includes MUPs encoded by central genes in the MUP cluster, as well as those encoded by peripheral genes such as Darcin/Mup20 which binds most of the male pheromone SB2HT in urine and was the first MUP shown to have male pheromonal activity in its own right. This group includes rat MUPs (also called alpha-2U globulins) and other lipocalins such as major horse allergen Equ c 1 and boar salivary lipocalin, a pheromone-binding protein specifically expressed in the submaxillary glands of the boar. It belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381203  Cd Length: 158  Bit Score: 45.90  E-value: 1.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442734435  30 AVVKDFDVNKFLGFWYEIALASKMgayglAHKEEKMGAMVVELK-----ENLLALTTTYYNEGHCVLEKVAATQVDGSAK 104
Cdd:cd19428    1 SVTRNFDVSKINGEWYSILLASDK-----REKIEENGSMRVFVEhihvlENSLAFKFHTKVNGECTELNLVADKTEKAGE 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442734435 105 YKVTrISGEKEVVVVATDYMTYTVIDITSLVAGAVHRAMKLYSRSLDNNGEALNNFQKIALKHGFSETDI 174
Cdd:cd19428   76 YSVT-YDGYNTFTILETDYDNYIMFHLINFKNGETFQLMELYGREPDVSSDIKERFVKLCEEHGIIKENI 144
lipocalin_Bla_g_4_Per_a_4 cd19440
major allergens Bla g 4 and Per a 4; Inhalant allergens from cockroaches are an important ...
 31-129 2.42e-05

major allergens Bla g 4 and Per a 4; Inhalant allergens from cockroaches are an important cause of asthma. Bla g 4 and Per a 4 are male pheromone transport lipocalins, and both are major allergens. Bla g 4 is produced by Blattella germanica (German cockroach) and has been shown to bind two biogenic amines, tyramine and octopamine which may be its physiological ligands. Per a 4 is produced by Periplaneta americana (American cockroach) and may bind different ligands from Bla g 4 or have different modes for tyramine/octopamine binding. This group belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381215  Cd Length: 148  Bit Score: 42.48  E-value: 2.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442734435  31 VVKDFDVNKFLGFWYEIALASKMGayglahkEEKMGAMVVEL---KENLLALTTTYYneghCVLEKvAATQVDGSAKY-- 105
Cdd:cd19440    7 LFTGFDYTKYLGVWYEAFRTPNAH-------EEQYKCWIDRFsldPEGPIAVTSVAY----DSRGK-NRVTLTGTVPVst 74

                         90       100       110
                 ....*....|....*....|....*....|.
gi 442734435 106 --KVTRISGEKEV-----VVVATDYMTYTVI 129
Cdd:cd19440   75 gnKFDIDYGDDEAwssqyWVLGTDYETYAIL 105
Blc COG3040
Bacterial lipocalin Blc [Cell wall/membrane/envelope biogenesis];
8-129 3.77e-05

Bacterial lipocalin Blc [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442274  Cd Length: 178  Bit Score: 42.14  E-value: 3.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442734435   8 MESIMLFTLLGLCVGLAAGTEA-----AVVKDFDVNKFLGFWYEIALaskmgaygLAHKEEKMGAMVVE---LKEN-LLA 78
Cdd:COG3040    1 MKRLRLLLALAAALLLAGCASAppppvTPVPPVDLDRYLGTWYEIAR--------LPHRFERGCVNVTAeysLREDgTIK 72

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442734435  79 LTTTYYN--EGHcvlEKVA---ATQVDGS--AKYKVT---RISGEKEVVVVATDYmTYTVI 129
Cdd:COG3040   73 VINRGRKgfDGE---WKEAegkARVVDDPtnAKLKVSffgPFYGDYWILALDPDY-QYALV 129
lipocalin_15-like cd19422
lipocalin 15 and similar proteins, such as chicken CALbeta; This subfamily includes ...
 39-179 4.55e-05

lipocalin 15 and similar proteins, such as chicken CALbeta; This subfamily includes uncharacterized human lipocalin 15, and chicken chondrogenesis-associated lipocalin (CAL) beta which is associated with chondrogenesis and inflammation. It belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381197  Cd Length: 143  Bit Score: 41.77  E-value: 4.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442734435  39 KFLGFWYEIALASKMGAYgLAHKEE-KMGAMVVE-LKENLLALTTTYYNEGHCVLEKVAATQVDGSAKYKVTRIsGEKEV 116
Cdd:cd19422    1 KFAGLWHVMAMASDCPVF-LGMKDHmTSSTTAIRpTPEGDLTMHTEFPLPDGCKQIEAEFQKSGQAGHFRVPEL-GKRDL 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442734435 117 VVVATDYMTYTVIDITSLVAGAVHRAMKLYSRSLDNNGEALNNFQKIALKHGFSETDIHILKH 179
Cdd:cd19422   79 RVMDTDYSSYAILYIYKELEGESSTMVQLYTRNQDVSPQLLQKFKELYPTLGLTEDMMVILPK 141
lipocalin_6 cd19426
Epididymal-specific lipocalin-6; Epididymal-specific lipocalin-6 (LCN6) may play a role in ...
 35-169 1.96e-04

Epididymal-specific lipocalin-6; Epididymal-specific lipocalin-6 (LCN6) may play a role in male fertility. It belongs to the lipocalin/cytosolic fatty-acid binding protein family which has a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381201  Cd Length: 144  Bit Score: 39.98  E-value: 1.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442734435  35 FDVNKFLGFWYEIALASKMGAYGLAHKEEKMGAMVVELK-ENLLALTTTYYNEGHCVLEKVAATQVDGSAKYKVTRIsGE 113
Cdd:cd19426    7 LDPKQLLGPWYVLAVASREKSFAVEKDMKNVAGVVVTLTpENNLRVLSSQHGLGGCSQSVTELLKRNSGWVFENPSI-GV 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 442734435 114 KEVVVVATDYMTYTVIdITSLVAG-AVHRAMKLYSRSLDNNGEALNNFQKIALKHGF 169
Cdd:cd19426   86 LELRVLGTNFRDYAIV-FTQLEFGdEPFNTVELYSRTETASQEAMGLFTKWSRGLGF 141
lipocalin_Blc-like cd19438
bacterial lipocalin Blc, Arabidopsis thaliana temperature-induced lipocalin-1, and similar ...
 32-169 5.47e-04

bacterial lipocalin Blc, Arabidopsis thaliana temperature-induced lipocalin-1, and similar proteins; Escherichia coli bacterial lipocalin (Blc, also known as YjeL) is an outer membrane lipoprotein involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Blc has a binding preference for lysophospholipids. This group includes eukaryotic lipocalins such as Arabidopsis thaliana temperature-induced lipocalin-1 (TIL) which is involved in thermotolerance, oxidative, salt, drought and high light stress tolerance, and is needed for seed longevity by ensuring polyunsaturated lipids integrity. This group belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381213  Cd Length: 143  Bit Score: 38.70  E-value: 5.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442734435  32 VKDFDVNKFLGFWYEIAlaskmgayGLAHKEEKMGAMVVE----LKENLLALTTTYYN--EGHcvlEKVA---ATQVDGS 102
Cdd:cd19438    1 VPNVDLDRYMGTWYEIA--------RLPNRFEKGCVNVTAtytlNDDGTISVVNRCRDgdEGK---WKEAegkARVVDPS 69

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442734435 103 --AKYKVTRisgekEVVVVATDymtYTVIDI-----TSLVAGAVHRAMKLYSRSLDNNGEALNNFQKIALKHGF 169
Cdd:cd19438   70 dnAKLKVSF-----FGPPFYGD---YWVLALdpdyqWALVGGPSRDYLWILSRTPQLSEETLQRLLEKARELGY 135
lipocalin_apoD-like cd19437
apolipoprotein D and similar proteins; Human apolipoprotein D (ApoD) is a small glycoprotein ...
 30-48 1.14e-03

apolipoprotein D and similar proteins; Human apolipoprotein D (ApoD) is a small glycoprotein associated with high density lipoproteins (HDL) in plasma. It appears promiscuous since it can bind hydrophobic ligands belonging to different lipid groups, with different shapes and biochemical properties; however, it exhibits specificity between very similar lipidic species. Some ligands, such as progesterone and arachidonic acid, bind to the ligand-binding pocket with high affinity, while others may interact with ApoD via its region of surface hydrophobicity. This hydrophobic surface cluster may facilitate its association with HDL particles and facilitate its insertion into cellular lipid membranes. Drosophila NLaz and Schistocerca Laz belong to this group, and share functional properties with human ApoD, including regulation of lifespan, lipid and carbohydrate metabolism control, and protection against oxidative stress or starvation. This group also includes Sandercyanin, a blue protein secreted in the skin mucus of blue forms of walleye, Sander vitreus. Walleye is an important golden yellow commercial and sport fish; the findings of blue walleye are recent. This group belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381212 [Multi-domain]  Cd Length: 160  Bit Score: 38.00  E-value: 1.14e-03
                         10
                 ....*....|....*....
gi 442734435  30 AVVKDFDVNKFLGFWYEIA 48
Cdd:cd19437    8 PVQEDFDVDKYLGRWYEIE 26
PRK10477 PRK10477
outer membrane lipoprotein Blc; Provisional
 31-48 2.68e-03

outer membrane lipoprotein Blc; Provisional


Pssm-ID: 182489  Cd Length: 177  Bit Score: 36.99  E-value: 2.68e-03
                         10
                 ....*....|....*...
gi 442734435  31 VVKDFDVNKFLGFWYEIA 48
Cdd:PRK10477  30 VVNNFDAKRYLGTWYEIA 47
lipocalin_2_12-like cd19432
lipocalin 2 and 12 and similar proteins; Lipocalin-2 (LCN2, also known as siderocalin, ...
 35-184 3.79e-03

lipocalin 2 and 12 and similar proteins; Lipocalin-2 (LCN2, also known as siderocalin, uterocalin, neutrophil gelatinase-associated lipocalin) is expressed in renal, endothelial, liver, smooth muscle cells, cardiomyocytes, in various populations of immune cells and dendritic cells. Roles ascribed to LCN2 include chemotactic and bacteriostatic effects, and iron trafficking. LCN2 can also act as a growth factor. It plays a key role in the pathophysiology of renal and cardiovascular diseases, and is involved in various deleterious processes, such as inflammation and fibrosis. It is used as a renal injury biomarker. Lipocalin 12 (LCN12) is an epididymis-specific protein which binds all-trans retinoic acid. It may act as a retinoid carrier protein within the epididymis and play a role in male reproduction. This group belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381207  Cd Length: 154  Bit Score: 36.51  E-value: 3.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442734435  35 FDVNKFLGFWYEIALASKmgAYGLAHKE-EKMGAMVVELKENL-LALTTTYYNEGHCvlEKVAATQVDGSAKYKVTRIS- 111
Cdd:cd19432    1 FQDNQFQGKWYVVGLAGN--AILREDKDpQKMYATIYELKEDKsYNVTSVLFRKKKC--DYWIRTFVPGNQPGEFTLGNi 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442734435 112 -----GEKEVV-VVATDYMTYTVIDITSLVAGAVHRAMKLYSRSLDNNGEALNNFqkIALKHGFSETDIHILKHDYIEI 184
Cdd:cd19432   77 ksypgLTSYLVrVVSTNYNQHAMVFFKKVSQNREYFKITLYGRTKELTSELKENF--IRFSKSLGLPENHIVFPVPIDQ 153
lipocalin_10-like cd19425
Epididymal-specific lipocalin-10 and similar proteins; Epididymal-specific lipocalin-10 (LCN10) ...
 38-72 9.06e-03

Epididymal-specific lipocalin-10 and similar proteins; Epididymal-specific lipocalin-10 (LCN10) may play a role in male fertility, and may act as a retinoid carrier protein within the epididymis. It belongs to the lipocalin/cytosolic fatty-acid binding protein family which has a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381200  Cd Length: 111  Bit Score: 34.55  E-value: 9.06e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 442734435  38 NKFLGFWYEIALASKMGAYGLAHKEEKMGAMVVEL 72
Cdd:cd19425    3 SKFSGFWYILATATDAQGFLPARDKRKLGASVVKV 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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