CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407228378  828 CGGEL-GDYTGYIESPNYPGDYPANAECVWHIAPPPKRRILIVVPEIFLPIEDECG-DVLVMRKSASPTSVTTYETCqTY 905
Cdd:cd00041     1 CGGTLtASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSyDYLEIYDGPSTSSPLLGRFC-GS 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 407228378  906 ERPIAFTSRSRKLWIQFKSNEANSGKGFQVPYVT 939
Cdd:cd00041    80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 407228378   720 GYFSADGFKPCQACPVGTYQPEPGRTGCFPCGGGLLTKHTGTASFQDC 767
Cdd:pfam07699    1 GTYSNTGLEPCIPCPRGTYQPEEGQLSCLACPLGTTTDSPGATSISDC 48

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 407228378   275 CAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTC 310
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 407228378   316 CLMNNGGCDHFCRNTVGSFECGCQKGHKLLTDERTC 351
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 407228378   396 CSMNNGSCEQGCVNTKGSYECVCPPGRRLHWNQKDC 431
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 407228378  348 ERTCQDIDECS-FERTCDHICINSPGSFQCLCRRGYTL 384
Cdd:cd01475   181 GKICVVPDLCAtLSHVCQQVCISTPGSYLCACTEGYAL 218

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 407228378   166 CMNKDHGCAHICRETPkGGVACDCRPGFDLAQNQKDC 202
Cdd:pfam14670    1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQDDGRTC 36

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407228378  828 CGGEL-GDYTGYIESPNYPGDYPANAECVWHIAPPPKRRILIVVPEIFLPIEDECG-DVLVMRKSASPTSVTTYETCqTY 905
Cdd:cd00041     1 CGGTLtASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSyDYLEIYDGPSTSSPLLGRFC-GS 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 407228378  906 ERPIAFTSRSRKLWIQFKSNEANSGKGFQVPYVT 939
Cdd:cd00041    80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407228378    837 GYIESPNYPGDYPANAECVWHIAPPPKRRILIVVPEIFLPIEDECG-DVLVMRKSASPTSVTTYETCQTYERPIAFTSRS 915
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEyDYVEIYDGPSASSPLLGRFCGSEAPPPVISSSS 80

                            90       100
                    ....*....|....*....|..
gi 407228378    916 RKLWIQFKSNEANSGKGFQVPY 937
Cdd:smart00042   81 NSLTLTFVSDSSVQKRGFSARY 102

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 407228378   720 GYFSADGFKPCQACPVGTYQPEPGRTGCFPCGGGLLTKHTGTASFQDC 767
Cdd:pfam07699    1 GTYSNTGLEPCIPCPRGTYQPEEGQLSCLACPLGTTTDSPGATSISDC 48

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 407228378   275 CAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTC 310
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 407228378   316 CLMNNGGCDHFCRNTVGSFECGCQKGHKLLTDERTC 351
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 407228378   396 CSMNNGSCEQGCVNTKGSYECVCPPGRRLHWNQKDC 431
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 407228378     33 DVDECSEGtDDCHIDAICQNTPKSYKCLCKPGYKgEGRQCE 73
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 407228378  348 ERTCQDIDECS-FERTCDHICINSPGSFQCLCRRGYTL 384
Cdd:cd01475   181 GKICVVPDLCAtLSHVCQQVCISTPGSYLCACTEGYAL 218

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 407228378    353 DIDECSFERTCDH--ICINSPGSFQCLCRRGYT 383
Cdd:smart00179    1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 407228378  301 FTLQPDGKTCKDINECLMNNGGCDHFCRNTVGSFECGCQKGHKLLTDERT 350
Cdd:cd01475   175 LTKKFQGKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 407228378     74 DIDECENdyyNGGCVHD--CINIPGNYRCTCFDGFmlaHDGHNC 115
Cdd:smart00179    1 DIDECAS---GNPCQNGgtCVNTVGSYRCECPPGY---TDGRNC 38

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 407228378   166 CMNKDHGCAHICRETPkGGVACDCRPGFDLAQNQKDC 202
Cdd:pfam14670    1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQDDGRTC 36

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|..
gi 407228378    117 DVDECQDNNG-GCQQICVNAMGSYECQCHSGF 147
Cdd:smart00179    1 DIDECASGNPcQNGGTCVNTVGSYRCECPPGY 32

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407228378  828 CGGEL-GDYTGYIESPNYPGDYPANAECVWHIAPPPKRRILIVVPEIFLPIEDECG-DVLVMRKSASPTSVTTYETCqTY 905
Cdd:cd00041     1 CGGTLtASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSyDYLEIYDGPSTSSPLLGRFC-GS 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 407228378  906 ERPIAFTSRSRKLWIQFKSNEANSGKGFQVPYVT 939
Cdd:cd00041    80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407228378    837 GYIESPNYPGDYPANAECVWHIAPPPKRRILIVVPEIFLPIEDECG-DVLVMRKSASPTSVTTYETCQTYERPIAFTSRS 915
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEyDYVEIYDGPSASSPLLGRFCGSEAPPPVISSSS 80

                            90       100
                    ....*....|....*....|..
gi 407228378    916 RKLWIQFKSNEANSGKGFQVPY 937
Cdd:smart00042   81 NSLTLTFVSDSSVQKRGFSARY 102

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 407228378   720 GYFSADGFKPCQACPVGTYQPEPGRTGCFPCGGGLLTKHTGTASFQDC 767
Cdd:pfam07699    1 GTYSNTGLEPCIPCPRGTYQPEEGQLSCLACPLGTTTDSPGATSISDC 48

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 407228378   275 CAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTC 310
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 407228378   316 CLMNNGGCDHFCRNTVGSFECGCQKGHKLLTDERTC 351
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 407228378    33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPG 64
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 407228378   33 DVDECSEGtDDCHIDAICQNTPKSYKCLCKPGYkgEGRQCE 73
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGY--TGRNCE 38

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|..
gi 407228378    84 NGGCVHDCINIPGNYRCTCFDGFMLAHDGHNC 115
Cdd:pfam14670    5 NGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 407228378  115 CLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHT 155
Cdd:cd01475   184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 407228378   206 CNYGNGGCQHSCEDTDTGPMCGCHQKYALHADGRTC 241
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.

                           10        20
                   ....*....|....*....|..
gi 407228378   294 RCSCPVGFTLQPDGKTCKDINE 315
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|..
gi 407228378    392 DVDECSMNNGsCEQG--CVNTKGSYECVCPPG 421
Cdd:smart00179    1 DIDECASGNP-CQNGgtCVNTVGSYRCECPPG 31

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 407228378     74 DIDECENdyyNGGCVHD--CINIPGNYRCTCFDGFmlaHDGHNC 115
Cdd:smart00179    1 DIDECAS---GNPCQNGgtCVNTVGSYRCECPPGY---TDGRNC 38

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 407228378   166 CMNKDHGCAHICRETPkGGVACDCRPGFDLAQNQKDC 202
Cdd:pfam14670    1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQDDGRTC 36

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.

                           10        20
                   ....*....|....*....|..
gi 407228378    99 RCTCFDGFMLAHDGHNCLDVDE 120
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|..
gi 407228378  117 DVDECQDNNG-GCQQICVNAMGSYECQCHSGF 147
Cdd:cd00054     1 DIDECASGNPcQNGGTCVNTVGSYRCSCPPGY 32